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Your search keyword '"G. P. Franzè"' showing total 2 results
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2 results on '"G. P. Franzè"'

1. Synthesis of N1-substituted benzamidines. Effects on blood coagulation, platelet aggregation and antiarrhythmic activity

Author

R, Ferroni, D, Simoni, S, Manfredini, M, Guarneri, P, Orlandini, M, Barbieri, G P, Franzè, and A, Mugelli

Subjects
Male, Sheep, Platelet Aggregation, Action Potentials, Anticoagulants, Heart, In Vitro Techniques, Benzamidines, Electrophysiology, Mice, Structure-Activity Relationship, Animals, Humans, Partial Thromboplastin Time, Anti-Arrhythmia Agents, Platelet Aggregation Inhibitors
Abstract

A series of N1-substituted-4-alkoxybenzamidines was synthesized and tested in vitro for their inhibitory effects on blood coagulation and agonist induced platelet aggregation. The antiarrhythmic activity against chloroform-induced arrhythmias in mice was also evaluated. The biological activity of the title compounds is reported in comparison with that of procainamide; among the new products described, IVi and IVe were found to have the most potent anti-platelet and antiarrhythmic activity, respectively. The structure-activity relationships are discussed.

Published
1995

2. Hematological indices of erythropoietin administration in athletes

Author

Giovanni Grazzi, Fabio Manfredini, C. Guglielmini, E. De Paoli Vitali, M. Masotti, Gianni Mazzoni, S. Bartalotta, Giorgio Ricci, I. Casoni, C. Borsetto, G. P. Franzè, F. Conconi, F. Rigolin, M. Patracchini, and E. Ballarin

Subjects
Adult, Erythrocyte Indices, Male, medicine.medical_specialty, Erythrocytes, Reticulocytes, Doping, Erythropoietin, Injections, Subcutaneous, Iron, Population, Physiology, Physical Therapy, Sports Therapy and Rehabilitation, Hematocrit, Hemoglobins, hemic and lymphatic diseases, Internal medicine, Fetal hemoglobin, medicine, Humans, Orthopedics and Sports Medicine, education, Mean corpuscular volume, Fetal Hemoglobin, Erythrocyte Volume, education.field_of_study, Hematology, medicine.diagnostic_test, business.industry, Transferrin, Oxygen transport, Creatine, Ferritins, Immunology, Erythrocyte Count, gamma-Globulins, Hemoglobin, business, Sports, medicine.drug
Abstract

Recombinant human erythropoietin (EPO), commercially available since 1988, is thought to be used by athletes in aerobic sports for the purpose of increasing oxygen transport and aerobic power. In an attempt to identify EPO administration, we have studied the peripheral blood of 20 subjects practising sports at an amateur level. Automated cytometry was performed on the blood samples before and during 45 days of EPO treatment. The same hematological indices were determined for a control population that consisted of 240 elite athletes from various sports. As expected following EPO treatment, RBC, [Hb] and Hct increased significantly (increments of 8%, 6.3% and 11%, respectively). A significant increase in reticulocyte count was also observed. In addition, automated erythrocyte analysis showed a significant increase in cells with a volume > 120 fl and hemoglobin content (HC)

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