1. A bifunctional heterodimeric insect neuropeptide analog
- Author
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G. M. Holman, G. M. Coast, Ronald J. Nachman, and William F. Haddon
- Subjects
Malpighian tubule system ,Insecta ,media_common.quotation_subject ,Molecular Sequence Data ,Neuropeptide ,Cockroaches ,Oviducts ,Insect ,Malpighian Tubules ,Insect Control ,Biochemistry ,Pentapeptide repeat ,Gryllidae ,chemistry.chemical_compound ,House cricket ,Animals ,Amino Acid Sequence ,Bifunctional ,media_common ,Dose-Response Relationship, Drug ,biology ,Neuropeptides ,fungi ,Biological activity ,biology.organism_classification ,Peptide Fragments ,chemistry ,Acheta ,Insect Hormones ,Digestive System - Abstract
The synthesis and biological activity of a bifunctional, heterodimeric insect neuropeptide analog are described. The heterodimer is composed of the C-terminal pentapeptide active core regions of the leucokinin/achetakinin and pyrokinin neuropeptide families linked via their N-terminal amino groups with a succinyl diacid moiety. Members of the leucokinin/achetakinin family can induce fluid secretion in malpighian tubules of the house cricket, Acheta domesticus, whereas the pyrokinins demonstrate activity in a cricket oviduct myotropic bioassay. No cross-activity is observed for the two neuropeptide families in these bioassays. However, the heterodimer elicits responses in both Acheta bioassays. Such a bifunctional analog may in future serve as a template for the design of stable, bifunctional pest insect control agents of greater efficiency. more...
- Published
- 2009
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