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A one-pot three components synthesis of substituted bis[1-N,7-N-diethoxyphthalimido-4,4′-{3,5-dimethyl-4-(4-N,N-dimethylaminophenyl)-4,7-dihydro-1H-dipyrazolo[3,4-b;4′,3′-e] pyridin-8-yl}-phenyl] in moderate to high yields has been achieved by a two-step reaction. All the synthesized compounds evaluate against cytomegalovirus and varicella-zoster virus in human embryonic lung cells.

Thiazolidin-4-one fused pyrimidines, [1,5]-benzodiazepines and their oxygen substituted hydroxylamine derivatives have been screened for antibacterial, antifungal and antimalarial activity. Bacillus subtilis, Escherichia coli, Proteus mirabilis and Salmonella typhi were used for antibacterial screening. Aspergillus fumigatus and Candida albicans were used for antifungal screening and Plasmodium species were used for antimalarial screening. The antibacterial and antifungal activities are expressed in terms of zone of inhibition and antimalarial activity is expressed in IC(50) value. Fifteen compounds 2Xa, 2Xb, 2Xc, 2Xs, 3IV, 3Va, 3Vc, 3VIIIa, 3VIIIh, 3IXa, 3IXb, 3IXc, 3Xa, 4IXa and 4Xa were tested for antibacterial as well as antifungal activity and seven compounds 2IXb, 2Xb, 3VIIIc, 3Xc, 4IXa, 4Xa and 4IXw were tested for antimalarial activity. Streptomycin, griseofulvin and chloroquine were taken as standard drugs in antibacterial, antifungal and antimalarial activity, respectively. The compound 2Xs was found significant antimicrobial against Bacillus subtilis, E. coli, Aspergillus fumigatus and Candida albicans as well as compound 3Xa was significant antimicrobial against Bacillus subtilis, E. coli, Salmonella typhi, Aspergillus fumigatus and Candida albicans. The compound 2Xb showed significant antimalarial activity.

A facile synthesis of 5,5'-(1,4-phenylene)bis(3-aryl-2-pyrazolines) 4a-g has been achieved by the cyclo-addition reaction of hydrazine hydrate with bis-substituted chalcones 3a-g, which in turn were prepared by the Clasien-Schmidt condensation of p-substituted acetophenones 1a-g with terephthaldehyde. Condensation of 4a-g with omega-bromoalkoxyphthalimides 5a-b afforded the titled compounds 6a-n, some of which exhibited significant antimalarial as well as antimicrobial activity.

Mebendazole is a well known anti-helimintic and belongs to the benzimidazole group of medicines. In order to achieve better medicinal results, i.e. enhanced activity and low toxicity, structural modifications are made in the existing drugs. Some 5-benzoyl-N-[1-(alkoxyphthalimido) benzimidazol-2-yl] carbamic acid methyl ester(3a-c)and 5-benzoyl-N-[1-(2,3-bis oxyphthalimido∕oxysuccinimido propyl benzimidazol-2-yl) carbamic acid methyl ester(7a-b)have been synthesized from two different routes. Structures of the compounds have been established on the basis of elemental analysis and spectral studies. All the synthesized compounds(3a-c)and(7a-b)were assayedin vitrofor antimicrobial activity against mebendazole (itself) and standard [ciprofloxacin (antibacterial) and fluconazole (antifungal)].

1,3-Thiazolidine-2,4-dione 2 has been synthesized by the cyclisation reaction of thiourea and chloroacetic acid in the presence of ethanol. The reaction of compound 2 with substituted aromatic aldehyde afforded the corresponding derivatives of substituted 5-benzylidene-1,3-thiazolidinone-2,4-dione 3a–d, which upon reflux with ω-bromoalkoxyphthalimide gave 2-{[-5-(substituted benzylidine)-2,4-dioxo-1,3-thiazolidine-3-yl]alkoxy} -1H-isoindole-1,3(2H)-dione 4a–i. Further, compounds 4a–i were treated with phenyl hydrazine and 2,4 dinitro phenyl hydrazine in the DMF to yield the title compound 2-[5-oxo-2,3-substituted diphenyl-2H-pyrazolo[3,4-d][1,3]thiazol-6(5H)-yl)alkoxy]-1H-isoindole-1,3(2H)-dione 5a–r. Structures of newly synthesized compounds were established based on elemental analysis, IR, 1H NMR and mass spectral data. Synthesized compounds have been assayed for their antibacterial activities against B. subtilis, K. pneumoniae, P. aeruginosa and S. aureus and antifungal activities against A. fumigatus ...

Some novel azaimidoxy compounds viz. 2-{[(4-chlorophenyl)diazenyl]oxy}-1H-isoindole-1,3-(2H)-dione (Va), and 1-{[1-naphthyldiazenyl]oxy}pyrrolidine-2,5-dione (IVc), etc. have been synthesized by a simple diazotization reaction followed by a coupling with 2-hydroxy-1H-isoindole-1,3(2H)-dione (III)/1-hydroxypyrrolidine-2,5-dione (II) of corresponding aromatic primary amine derivatives at a suitable pH. A similar reaction with a [1,3]thiazolo[4,5-b]pyridin-2-amine (VIII) lead us to some interesting results variable with a pH. The structure of all synthesized compounds has been established by IR, 1H NMR, and mass studies. These compounds have been screened for antimicrobial activities in order to evaluate the possibility of the derivatives to be used as potential chemotherapeutic agents.

Hydroxyquinoline 1 reacts with ethyl chloroacetate in the presence of anhydrous K2CO3 to produce ethyl (quinolin-8-yloxy)acetate 2. Treatment of 2 with hydrazine hydrate forms 2- (quinolin-8-yloxy)acetohydrazide 3, which on condensation with various aldehydes 4a-e gives N'-{((1Z)-arylmethylene)-2-(quinolin-8-yloxy)}acetohydrazides 5a-e. These, on cyclization with mercaptosuccinic acid, yield (2-aryl-4-oxo-3-{((quinolin-8-yloxy)acetyl)amino}-1,3-thiazolidin- 5-yl) acetic acids 6a-e. Compounds 6a-e are further converted into acid chloride derivatives 7a- e by reaction with thionyl chloride. Subsequent treatment of 7a-e with N-hydroxysuccinimide in the presence of TEA furnishes the title compounds 8a-e. Antibacterial and antifungal activities of the final compounds have been evaluated and all the compounds have shown significant inhibition of bacterial and fungal growth.

3-Methylpyrazol-5-one3reacts with substituted benzaldehydes4a-din the presence of anhydrous sodium acetate to produce the corresponding 4-arylidene-5-methyl-2,4-dihydro-pyrazol-3-ones5a-dand the condensation of5a-dwith 2-bromoalkoxy-1H-isoindole-1, 3-(2H)-diones2a-cfurnished corresponding 2-[2-(4-arylidene-3-methyl-5-oxo-4,5-dihydro-pyrazol-1-yl)alkoxy]-isoindole-1,3-diones6a-l, which on cyclisation with o-phenylendiamine give titled compounds7a-l. All the synthesized compounds have been characterized by elemental analysis and spectral data and screened for their antibacterial properties against various bacterial strains in order to obtain chemotherapeutic properties.

A variety of phthalimido(2-aryl-3-(5'-(4''-pyridyl)-1',3',4'-thiadiazol-2'-yl)-4-oxothiazolidin-5- yl)ethanoates 7a-h and 3-N-alkoxyphthalimido-2-isonicotinoylhydrazido-1,3-thiazolidin-4-ones 9a-c were synthesized using thiosemicarbazide of isoniazid 2 by two alternative pathways. The structures of these compounds were confirmed by IR, NMR ( 1 H & 13 C) and Mass spectral studies. Synthesized compounds 7a-h and 9a-c were evaluated for their antimicrobial activity. Some of the compounds exhibited good antimicrobial activity compared to standard drugs. The structure activity relationships of synthesized compounds have also been studied in order to develop the most potential antimicrobial agent for preclinical evaluation.

Reaction of acetylacetone with hydrazine hydrate gave 3,5-dimethyl-1H-pyrazole (1) which when reacted with ethylchloroacetate in acetone and thiosemicarbazide yielded ethyl-3,5-dimethyl-1H-pyrazol-1-yl-acetate (2) and 2-[(3,5-dimethyl-1H-pyrazol-1-yl)acetyl]hydrazine carbothioamide (3) respectively. Compound 3 acted as a key intermediate for both the series of final compounds. In one pathway, it was converted to corresponding thiadiazole (11) by treatment with conc. H 2 SO 4 and NH 3 which on condensation with (ω-bromoethoxyphthalimide (10) gave 5-[(3,5-dimethyl-1H-pyraz 1-yl)methyl]-N-ethoxyphthalimido-1,3,4-thiadiazol-2-amine (12). In another pathway, 3 reacted with chloroacetic acid to furnish 2-[(3,5-dimethyl-1H-pyrazolyl)-4-oxo-1,3-thiazolidin-2-ylidene acetohydrazide (4). Reaction of 4 with various araldehydes (5a-d) gave 5-[(4-substituted phenyl)methylidene]-4-oxo-1,3-thiazolidin-2-ylidene]-2-[(3,5-dimethyl-1H-pyrazolyl)acetohydrazide (6a-d) which were further treated in two alternate routes. Firstly, with 10 to yield 5-{[(4-substituted phenyl)methylidene]-3-N-ethoxyphthalimido-4-oxo-1,3-thiazolidin-2-ylidene}-2-(3,5-dimethyl-1H-pyrazolyl)acetohydrazide (8a-d). Cyclisation of these derivatives using hydroxylamine hydrochloride produced the target compounds 3-(4-substituted phenyl)-6-N-ethoxyphthalimido-3,3a-dihydro[1,3]thiazolo[4,5-c]isoxazol-5(6H)-ylidene-2-(3,5-dimethyl-1H-pyrazol-1-yl)acetohydrazide (9a-d). In parallel, 6a-d were first cyclised with hydroxylamine hydrochloride to give 3-[(4-substituted phenyl)-3,3a-dihydro[1,3]thiazolo[4,5-c]isoxazol-5(6H)-ylidene-2-(3,5-dimethyl-1H-pyrazol-1-yl)acetohydrazide (7a-d) and then condensed with 10 to yield the final compounds 9a-d. Structural elucidation of synthesized compounds was accomplished by IR, 1 H NMR, 13 C NMR and mass spectral data. Final compounds were screened for their antimicrobial activity.

Synthetic Organic Chemistry Research Laboratory, Department of Chemistry, M. L. Sukhadia University. Udaipur-313 001, Rajasthan, India E-mail: ghntalesara@yahoo.com Manuscript received 11 January 2010, revised 19 April 2010. accepted 31 May 2010 A series of 1-{2-(phthalimido-N-oxy)-ethyl}-4-(4-substituted phenyl)-2,6-dimethyl-l-1,4-dihydro-3,5-bis-N-(-4-oxo· 2-phenylquinazolin-3(4H}-ylcarboxamides (6a-d) have been synthesized via a multistep reaction suquence. Ethyl acetoacetate, various araldehydes and ammonia were condensed in ethanol to yield diethyl 4-(4-substituted phenyl)-2.6- dimethyl-1,4-dihydropyridine-3,5-dicarboxylate (2a-d). Ester group of these 2a-d was replaced by hydrazinehydrate in dioxane to give 4-(4-substituted phenyl)-2,6-dimcthyl-1,4-dihydropyridine-3,5·dicarbohydrazidc (3a-d). These werefurther treated withbenzoxazine-4(3H)-one to give 4-(4-substituted phenyl)-2,6-dimethyl)1,4-dihydro-3,5·bis-N-(4-oxo-2- phenylquinazolin-3(4H)-ylcarboxamides (4a-d). Final compounds 6a-d were obtained by refluxing 4a-d with bromoethoxyphtltalimide (5). The structures or the synthesized compounds were assigned on the basis of elemental analysis, IR, 1HNMR and mass spectral data.

Some alkoxy-1H-isoindole-1,3(2H)-dione derivatives of phenothiazine and indolc have been prepared by the action of 2-(bromoalkoxy)-1H-isoindole-1,3(2H)-dione with the corresponding heterocycles.

Synthesis of novel N'-[2-(4-substitutedphenyl)-3-N-ethoxyphthalimido-5-oxoimidazolidene-1-yl]-2-(quinoline-8-yloxy)acetamide derivatives (6a-e) with potential biological activities were carried out by adopting the reaction scheme given below. Compound ethyl-(quinoline-8-yloxy)acetate (2) was synthesized by refluxing 8-hydroxyquinoline with ethylchloroacetate in presence of K 2 CO 3 . Ethyl-(quinoline-8-yloxy)acetate (2) was converted to corresponding hydrazide (3) on treatment with hydrazine hydrate which on further condensation with various araldehydes gave respective Schiff's bases (4a-e). These on cyclisation with glycine yielded corresponding oxoimidazolidenes (5a-e). Active H of imidazolidinones (5a-e) was replaced by ethoxy phthalimide to yield final products (6a-e).

Keeping in view the pharmacological potential of thiazolidinones and phenothiazines, the title compounds containing these nuclei have been synthesized. Reaction of 10-(chloroacetyl)phenothiazine 1 with hydrazine hydrate gives 10(hydrazinoacetyl)phenothiazine 2, which on treatment with various aromatic aldehydes yields 10-[4-(arylidene)hydrazino acetyl] phenothiazine 3a-d. These Schiff bases 3a-d underwent cyclization when treated with mercaptosuccinic acid in presence of anhydrous zinc chloride to give [2-aryl-4-oxo-3-[{2-oxo-2-(phenothiazin-10-yl)ethyl}amino]-1,3-thiazolidin-5yl]ethanoic acid 4a-d, which are converted to [2-aryl-4-oxo-3-[{2-oxo-2-(phenothiazin-10-yl)ethyl}amino]-1,3-thiazolidin5-yl] ethanoyl chloride 5a-d on reaction with thionyl chloride. Subsequent treatment of 5a-d with N-hydroxyphthalimide or N-hydroxysuccinimide furnished phthalimido or succinimido-[2-aryl-4-oxo-3-[{2-oxo-2-(phenothiazin-10-yl)ethyl}amino]1,3-thiazolidin-5-yl]ethanoate 6a-h. The constitution of all the above products have been supported by elemental analysis and spectral studies. Antibacterial and antifungal activities of the final compounds have been evaluated and all the compounds have shown significant inhibition of bacterial and fungal growth.

Treatment of benzoxazine 1 with hydrazine hydrate in ethanol furnished 3-amino-2-phenylquinazolin-4-(3H)-one 2, which upon condensation with aldehydes 3a-d yielded the corresponding 3-arylideneamino derivatives 4a-d. Cyclization of these derivatives using mercaptosuccinic acid afforded 1,3-thiazolidin-4-one ethanoic acids 5a-d, which after esterification with N-hydroxyphthalimide or N-hydroxysuccinimide via acid chlorides produced the respective ethanoic esters 7a-e.

Synthetic Organic Chemistry Laboratory, Department of Chemistry, M. L. Sukhadia University, Udaipur-313 001, Rajasthan, India E-mail : gtalesara@yahoo.com Manuscript received 15 December 2008, revised 15 May 2009, accepted 26 June 2009 Reaction of acetylacetone with hydrazine hydrate gave 3,5-dimethyl-1H-pyrazole (1) which when reacted with ethylchloroacetate in acetone and thiosemicarbazide yielded ethyl-3,5-dimethyl-1H-pyrazol-l-yl-acetate (2) and 2-[(3,Sdimethyl-1H-pyrazol-1-yl)acetyl]hydrazine carbothioamide (3) respectively. Compound 3 acted as a key intermediate for both the series of final compounds. In one pathway, it was converted to corresponding thiadiazole (11) by treatment with cone. H2SO4 and NH3 which on condensation with co-bromoethoxyphthalimide (10) gave 5-[(3,5-dimethyl-1H-pyrazoll-yl)methyl]-N-ethoxyphthalimido-1,3,4-thiadiazol-2-amine (12). In another pathway, 3 reacted with chloroacetic acid to furnish 2-[(3,5-dimethyl-1H-pyrazolyl)-4-oxo-1,3-thiazolidin-2-ylidene acetohydrazide (4). Reaction of 4 with various araldehydes (5a-d) gave 5-[(4-substituted phenyl)methylidene]-4-oxo-1,3-thiazolidin-2-ylidene)-2-[(3,5-dimethyl-1H-pyrazolyl)acetohydrazide (6a-d) which were further treated in two alternate routes. Firstly, with 10 to yield 5-{[(4- substituted phenyI) methyIidene)-3-N -ethoxyph thalimido -4-oxo-1, 3-thiazoli din-2-y lidene}-2-(3, 5-dimethyl-1H-pyrazolyl)acetohydrazide (8a-d). Cyclisation of these derivatives using hydroxylamine hydrochloride produced the target compounds 3-(4-substituted phenyl)-6-N-ethoxyphthalimido-3,3a-dihydro[1,3)thiazolo[4,5-c)isoxazoi-5(6H)-ylidene-2-(3,Sdimethyi-1H-pyrazol-1-yl)acetohydrazide (9a-d). In parallel, 6a-d were first cyclised with hydroxylamine hydrochloride to give 3-[( 4-substituted phenyl)-3,3a-dihydro[1 ,3] thiazolo [ 4,5-c ]isoxazoi-5(6H)-ylidene-2-(3,5-dimethyl-1H -pyrazol-1- yl)acetohydrazide (7a-d) and then condensed with 10 to yield the final compounds 9a-d. Structural elucidation of synthesized compounds was accomplished by IR, 1H NMR, 13C NMR and mass spectral data. Final compounds were screenedfor their antimicrobial activity.

Novel spiro-isatin-thiazolidino-pyrazoline compounds containing alkoxyphthalimide moiety have been synthesized through a four step pathway starting from chalcone 1a-e. Cyclization of these with hydrazine hydrate in absolute ethanol have yielded 1-acetyl-3-(4-aminophenyl)-5-(4-substituted phenyl)-2-pyrazoline 2a-e. Acid catalyzed condensation of 2a-e with isatin 3 has yielded 3-[4-{1-acetyl-5-(4-substituted phenyl)-2-pyrazoline-3-yl}phenylimino]indole-2-one 4a-e. These Schiff bases on reaction with mercaptoacetic acid in presence of anhydrous ZnCl 2 gave their corresponding spirothiazolidinone derivatives 5a-e. Subsequent treatment with bromoethoxyphthalimide yielded titled compounds 3'-{4-(1-acetyl-5-(4-substituted phenyl)-2-pyrazoline-3-yl)phenyl}-1-N-ethoxyphthalimido-4'H-spiro[indole-3,2'-[1,3]thiazolidene]-2,4'-1H-dione 6a-e.

Synthetic Organic Chemistry Research Laboratory, Department of Chemistry, M. L. Sukhadia University, Udaipur-313 001, Rajasthan, India E-mail : gtalesara@yahoo.com Manuscript received 30 September 2008, revised 1 April 2009, accepted 26 June 2009 Synthesis of novel N'-[2-(4-substitutedphenyi)-3-N-ethoxyphthalimido-5-oxoimidazolidene-1-yl]-2-(quinoline-8- yloxy)acetamide derivatives (6a-e) with potential biological activities were carried out by adopting the reaction scheme given below. Compound ethyl-(quinoline-8-yloxy)acetate (2) was synthesized by renuxing 8-hydroxyquinoline with ethylchloroacetate in presence of K2CO3. Ethyl-(quinoline-8-yloxy)acetate (2) was converted to corresponding hydrazide (3) on treatment with hydrazine hydrate which on further condensation with various araldehydes gave respective Schiff's bases (4a-e). These on cyclisation with glycine yielded corresponding oxoimidazolidenes (5a-e). Active H of lmidazolidinones (5a-e) was replaced by ethoxy phthalimide to yield final products (6a-e).

Synthetic Organic Chemistry Laboratory, Department of Chemistry, M. L. Sukhadia University, Udaipur-313 001, Rajasthan, India E-mail : gtalesara@yahoo.com Manuscript received 11 June 2008, revised 5 November 2008, accepted 23 December 2008 Treatment of benzoxazine 1with hydrazine hydrate in ethanol furnished 3-amino-2-phenylquinazolin-4-(3H)- one 2, which upon condensation with aldehydes 3a-d yielded the corresponding 3-arylideneamino derivatives 4a-d. Cyclization of these derivatives using mercaptosuccinic acid afforded 1 ,3-thiazolidin-4-one ethanoic acids 5a-d, which after esterification with N-hydroxyphthalimide or N-hydroxysuccinimide via acid chlorides produced the respective ethanoic esters 7a-e.

4-Chloro/methyl phenacyl bromide la-b reacted with thiourea to furnish 2-amino thiazole 2a-b through Hantzsch's process, which were converted to their thiazolidinone derivatives 4a-b, by the reaction of corresponding thiazolyl thiourea 3a-b with chloroacetic acid in the presence of sodium acetate. Subsequent treatment of 4a-b with aromatic aldehydes 5a-c, followed by condensation with ω-bromolkoxyphthalimides 7a-b afforded titled compounds 8a-l.

Some novel antiasthmatic theophylline derivatives have been synthesized and evaluated for biological activity. Oxygen substituted hydroxylamine compounds have been found to possess versatile pharmacological activities. Theophylline N-alkoxy-arylbiguanides 8a-d have been prepared by condensing corresponding N-alkoxyamine salt 6a-c with substituted aryldicyan-diamide 7, which in turn is prepared by Gabriel hydrolysis of corresponding alkoxyphthalimides 5a-c. Theophylline is converted to its sodium salt using sodium hydride and treated with bromoalkoxy phthalimide in DMF media. In an another attempt N-allyl theophylline 9 is brominated and condensed with double mole ratio of N-hydroxyphthalimide to obtain 2,3-bis-oxyphlhalimido-1-theophylline propane 11. Majority of these compounds have been screened for their antimicrobial activity.

Synthesis and characterization of 3H, 9H, 10H, 10aH-10-aryl-2-aryliminothiazolidino[4,5-b][1,5]benzodiazepines and their alkoxyphthalimide derivatives are described. Cyclization of 5-arylidene-2-aryliminothiazolidin-4-ones 1a-i with o-phenylenediamine in xylene furnishes the corresponding 1,5-benzodiazepines 2a-i. In another reaction route, 1a-i when condensed with ω-bromoalkoxyphthalimides 3a-c give 3-alkoxyphthalimido-5-arylidene-2-aryliminothiazolidin-4ones 4a-a' which on cyclization with o-phenylenediamine produce 9H, 10H, 10aH-3-N-(n-alkoxyphthalimido)-10-aryl-2aryliminothiazolidino[4,5-b][1,5]benzodiazepines 5a-a' in good yields. IPC: Int.Cl. 7 C 07 D The design and synthesis of 1,5-benzodiazepines and their derivatives have attracted much attention due to their wide pharmacological action as tranquilizers, sedatives, anaesthetics and anticonvulsants. Benzodiazepines were used as tranquilizer agents from 1960 when Librium 1 was introduced as tranquilizer. Clozapine lacks extra pyranydal side effects. Dilazep 2 has been tried for the treatment of chronic nephritis. A series of 7-dialkyl and spirocyclic-substituted azepines are being used for the treatment of hypertension and heart failure 3 . Several amino-oxy compounds have been tested as antimalarial agents and possess potent activity on P. falciparum clone 3D7 4 . Mamalis et al. 5 have reviewed interesting pharmacological properties of amino-oxy compounds. Thiazolidin-4ones were also found to possess a wide spectrum of biological activities such as anaesthetic, hypnotic, herbicidal, fungicidal, anti-tuberculostatic and antileprotic behaviour. The integration of structural features from different biologically active compounds in a single molecule is very interesting. Consequently there have been recent efforts for the production of novel and hybrid compounds possessing bioactivity with the potential of being incorporated into the drug discovery process as drug candidates.

Synthetic Organic Chemistry Laboratory, Department of Chemistry, Mohanlal Sukhadia University, Udaipur-313 001, India E-mail : gtalesara@yahoo.com; bsyadav2000@rediffmail.com Manuscript received 5 May 2004, revised 1 November 2004, accepted 5 January 2005 Biphcnyl-yl-4,4' -bisthiourea 1 reacts with monochloroacetic acid in presence of anhydrous sodium acetate to furnish p-bis-(2-iminothiazolidin-4-one-N2 -yl)hiphenyl 2. Condensation of ω-hromoalkoxyphthalimides 3a-c with 2 gave corresponding alkoxyphthalimidc derivatives 4a-c. In the compounds 4a-c, reactive methylene group of thiazolidinone ring at position-5 wascondensed with araldchydes 5a-c to give p-bis-(3-n-alkoxyphthalimido-5-arylidenc-2-iminothiazolidin-4-one-N2 -yl)biphenyls 6a-i. The titled compounds 7a-i were synthesized by cyclisation reaction of the compounds 6a-i with urea in the presence of anhydrous sodium acetate in acetic acid medium. In another reaction route, substituted benzaldehydes 5a-c were reacted first with 2 to givep-bis-(S-arylidene-2-iminothiazolidin-4-one-N2-yl)biphenyls 8a-c which could he cyclised with urea to furnish p-bis-(2-hydroxy-4-aryl-6-iminothiazolidino[4,5- b ]pyrimidin-N6-yllbiphenyls 9a-c. The compounds 6a-i and 7a-i were also synthesized by condensation reactions of 8a-c and 9a-c with 3a-c respectively.

Department of Chemistry, College of Science, M. L. Sukhadia University, Udaipur-313 001, India E-mail: gtalesara@yahoo.com Manuscript received 3 May 1999, revised 30 April 2001, accepted 5 June 2001 Some alkoxy-1H-isoindole-1,3(2H)-dione derivatives of phenothiazine and indole have been prepared by the action of i-(bromoalkoxy)- 1H-isoindole-1,3(2H)-dione with the corresponding heterocycles.

Frozen sections of the pectoral, gastrocnemius and cardiac muscles from seven different species of birds were stained for myofibrillar ATPase and for succinic dehydrogenase. Several methods of myofibrillar ATPase were used including different pre-incubation treatments. Myofibrillar ATPases were also measured biochemically and the pH profile of the activity was compared with the histochemical staining following pre-incubation at different pH. Myofibrils from the different muscles were also subjected to sodium dodecyl sulphate acrylamide gel electrophoresis in order to separate the low molecular weight components of myosin. The results demonstrated that histochemical methods can be applied, with a reasonable degree of confidence, to classifying fibres in avian muscles although the classification used for mammalian muscles needs to be modified. They also showed that avian muscles, particularly the pectoralis, varies considerably between species and their mode of locomotion.

Substituted aryl thioureas la-c react with chloroacetic acid in the presence of anhydrous sodium acetate to furnish 2-aryliminothiazolidin-4-ones 2a-c. Condensation of ω-bromoalkoxyphthalimides 3a-c with 2a-c give the corresponding alkoxyphthalimide derivatives of 2-aryliminothiazolidin-4-ones 4a-i. These on condensation with araldehydes 5a-c yield 3-N-(alkoxyphthalimido)-5-arylidene-2-aryliminothiazolidin-4-ones 7a-a'. In an alternative route 5a-c react with 2a-c to give 6a-i, which could be cyclised with urea in the presence of sodium acetate to yield the corresponding thiazolidinopyrimidine 8a-i. 7a-a' are also prepared from 6a-i with 3a-c, which give final compound 9a-a' on cyclisation. Alternatively, 8a-i when condensed with 3a-c also furnish the compounds 9a-a'. Evaluation of antimalarial and antibacterial activity is also reported.