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Introduction Borderline personality disorder (BPD) is a real source of suffering for people affected and for those around them. Objectives The aim of this study was to describe the socio-demographic and clinical characteristics of out patients with BPD consulting the psychiatry department of Hedi Chaker hospital in sfax tunisia during the period between January 2022 and October 2022. Methods It was a descriptive study. The population study consisted of patients diagnosed with BPD (DSM 5) consulting the psychiatry department of the hospital Hédi Chaker of Sfax tunisia during the period from January 2022 to October 2022. Sociodemographic and clinical data were collected using a predefined form. All statistical analyses were performed using the SPSS software package v 18. Results Among 700 adult patients referred to the psychiatric unit of hedi chaker hospital in sfax from january 2022 to october 2022, 35 patients (5%) were identified as meeting the criteria for BPD. The average age was about 35 years, 54.3% of the patients were men. They were married in 40% of cases.Only 31.4% of the patients had a regular job. The presence of a family psychiatric illness was noted in 48.5% of cases and 20% had a childhood psychiatric follow-up . The rates of sexual abuse, physical abuse, psychological abuse and neglect were 17.1%, 65.7% and 68.6% respectively. In our sample,48.6% of the patients had attempted suicide and 60% of them had committed self-harm. The most common means of attempted suicide was phlebotomy.No prior thoughts of suicide were mentioned, all suicide attempts were impulsive. Negative feelings and family conflicts motivated the suicide attempt (37.5% ,56.25%). Comorbid psychiatric disorder was mentioned in 54.3% and The most frequent comorbid psychiatric disorders was depression (20%). Pharmacotherapie was used in 88.6% of cases. Conclusions The results emphasize on the comorbidities with mainly depressive episodes and a high proportion of suicide attempts and self-harm. Moreover, this study confirms the impact of family conflicts and abuse in the development of this disorder Disclosure of Interest None Declared

Introduction Resting state electroencephalogram (EEG) abnormalities in schizophrenia (SCZ) suggest alterations in neural oscillatory activity. However, few studies have examined EEG coherence in this population. Objectives Therefore, this study investigated whether these electrophysiological characteristics differentiate schizophrenic patients from healthy controls. Methods This was a cross-sectional, descriptive, and analytical case-control study. The selected patients were followed for SCZ at the psychiatry "C" department at the Hedi Chaker hospital of Sfax. Patients were assessed by the Positive and Negative Schizophrenia scale (PANSS) and the Treatment Adherence Scale (MARS). They all benefited from an EEG at the service of functional explorations in Sfax. Student’s test was performed to compare the coherence values between groups. Results Thirty men including 15 schizophrenic patients and 15 age- and sex-matched controls were included. The average age was 40 years ±12.72 years for schizophrenics and 47.93 ± 15.61 years for healthy controls. Schizophrenics had an average PANSS of 64.6±22.7, and an average MARS score of 5.8 ± 3.09. In terms of intra-hemispheric coherence, Schizophrenic patients generally exhibited higher coherence at the Delta band compared to healthy controls. In contrast, schizophrenic patients appeared to have decreased intra-hemispheric connectivity for other frequency bands, particularly between the frontal and other brain lobes bilaterally. Conclusions In this study, we found that the schizophrenic patients had significantly higher coherence in the delta frequency band compared to the normal controls. These findings suggest that EEG can be a sensitive measure for diagnosing SCZ. Disclosure of Interest None Declared

Introduction Patients with Borderline Personality Disorder (BPD) require a significant amount of time and effort on the part of general practitioners and psychiatrists, resulting in longer visits and complex medical records, with a poor resolution of both physical and mental symptoms. These patients are likely to express feelings of anger and violence, compared to other patients which makes it difficult to deal with them. Objectives To determine attitudes toward patients with BPD among psychiatry and family medicine residents in Tunisia. To understand in addition the challenges that these professionals encounter in their everyday practice Methods An online anonymous questionnaires was distributed through social networks to psychiatry residents and family medicine resident. The attitudes of health professionals towards people with BPD was used to assess clinicians’ attitudes towards people with BPD. Results Thirty three clinicians were in the study. A high proportion of respondents (81.8%) were females .The age of the participants ranged from 25 to 34 years, with an average age of 28 years and 3 months (SD = 2.23).In our study 34% reported that they often see patients with borderline personality .The half of the participants (51.5%) reported a feeling being on guard when meeting borderlines while 36.4% were empathetic and neutral. The feeling of anger and frustration was reported with 12.1 % of the participants. The most frequent cause of these feelings was the difficulty of taking care of patients with BPD. The majority of the participants (51.5%) reported avoiding working with them. However, only 39.4% reported asking a colleague to replace them in their follow-up. The results of Attitudes of health professionals towards people with BPD Scale indicate that clinicians generally present a positive attitude towards patient BPD with a mean score 94.94(SD=18.60) Conclusions Working with patients with BPD can be challenging. Professionals’ attitude can create obstacles to effective communication and successful treatment. Therefore, all clinicians should receive more specific training to be able to deal with this condition. Disclosure of Interest None Declared

Introduction Functional impairment is a major target in the treatment of bipolar disorder (BD), but the magnitude and type of functional difficulties differ across patients. Objectives The aim of this study was to assess functioning and identify factors associated with global functioning in euthymic patients. Methods It was a descriptive cross-sectional study. The population study consisted of patients diagnosed with BD (DSM 5), who were euthymic and followed up at the psychiatry department of CHU Hedi Chaker. The Hamilton Depression Scale (HAM-D), the Young Mania Rating Scale (YMRS) and the Functioning Assessment Short Test (FAST) were used to assess depressive, manic symptoms and the functional impairment in bipolar patients respectively. All statistical analyses were performed using the SPSS software package v 18. Results We collected 40 patients. They had an average age of 36 years and the sex ratio (M/F) was 1. They had an educational level not exceeding primary studies in 46% of cases. The average scores of HAM-D and YMRS were 4.57±4.58 and 3.43±2.89 respectively. The average total functioning score of our patients was 19.13±16.5. Functional impairment was noted in 60% of them. The domains most affected were: occupational activity (62%), cognitive functioning (63%) and autonomy (50%). Fonctional impairement was associated with residual depressive and manic symptoms (p=0.013) and manic/hypomanic or depressive episodes with mixed features (p=0,005). Conclusions Greater efforts should be directed toward targeting functioning in patient care, as it constitutes the most meaningful endpoint of response to treatment, especially with occupational and cognitive rehabilitation, thus allowing patients to overcome the course of illness and carry fulfilling lives. Disclosure of Interest None Declared

Introduction Clinical evidence supports the interaction between genetic predisposition and environmental stressors on the emergence of positive psychotic symptoms. Childhood trauma might be a modifiable risk factor among adults with serious mental illness. Objectives The aim of our study was to investigate associations between childhood trauma (physical abuse, sexual abuse, emotional abuse, emotional neglect, and physical neglect) and symptoms of schizophrenia. Methods We included in our study 33 stabilized inpatients with schizophrenia at the Psychiatry C department at University Hospital in Sfax-Tunisia. Data on Sociodemographic and clinical variables were collected from medical records. Psychotic symptoms were evaluated using the Positive and Negative Syndrome Scale (PANSS). We used the Childhood Trauma Questionnaire-Short Form (CTQ-SF) to evaluate childhood trauma experiences. Results Our sample was exclusively composed of men with an average age of 35 years and 4 months. The majority of patients were unemployed (75.8%). Only 6.1% of them were married. Among the patients included in the study, 15.2% of our patients were illiterate. The majority of subjects were treated after a period of untreated psychosis (65.5%). The analysis revealed that 42.4% of our patients experienced childhood adversities with mean CTQ-SF total score 35.48 (SD=9.44) We found that positive and general psychopathology schizophrenia symptomatology were correlated to Childhood abuse (0.03; 0.004), emotional abuse (0.009; 0.004), physical neglect (0.02; 0.01), and emotional neglect (0.01). In addition, our analysis showed that only emotional abuse lead to more negative schizophrenia symptomatology (p=0.009).* Conclusions Several studies have shown an association between childhood trauma and specific symptoms of psychosis. Therefore, Childhood trauma should be considered and inquired about in the course of clinical care of schizophrenia patients. Disclosure of Interest None Declared

Introduction Schizophrenia is a neurodevelopmental process affecting approximately 1% of the population. Multiple studies have found that Childhood trauma is an important risk factor in the emergence and clinical course of schizophrenia. Objectives The purpose of this study was to assess the characteristics of schizophrenic inpatients with childhood trauma among a tunisian sample. Methods Stabilized inpatients with schizophrenia at the Psychiatry C department at University Hospital in Sfax were involved in our study. Sociodemographic and clinical data of patients were collected from medical records. We used Childhood Trauma Questionnaire-Short Form (CTQ-SF) to evaluate the occurrence of childhood maltreatment. Results We recruited 33 patients, all men with a mean age of 35 years and 4 months (SD=9.44 years). They were married in 6.1% and 24.2% of patients had regular work. The mean age of onset of the disorder was 24.42(3.25).The level of poor psychotropic medication adherence was 72.7%. According to CTQ-SF, 78.8% of patients had experienced child trauma with a mean score of 35.67 (SD =8.61). A rate of 39.4% reported having experienced one child trauma, while 60.6% reported having experienced more than one. We found high rates of emotional neglect (87.8%) while emotional and physical abuse during childhood were experienced by 39.4%, and 6% respectively and physical neglect were found in 30.3% of cases. Patients with more than one childhood trauma were found to have an earlier onset of psychosis (p=0.004) The occurrence of childhood trauma was not associated with the socio-demographic characteristics of the respondents or the clinical features of the disease. Conclusions The results point toward childhood emotional neglect being of specific importance to schizophrenia, which may be an area for future prevention and clinical attention. Disclosure of Interest None Declared

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Aim: The aim of this study was to explore the relationship between IL-1β-31T/C polymorphism and serum levels of IL-1β and the risk of acute heart failure (AHF)., Methods: A total of 320 dyspnea patients (160 with AHF and 160 without AHF) and 100 healthy subjects were included in this study. IL-1β genotyping was performed by PCR-restriction fragment length polymorphism technique., Results: Concentration of IL-1β was significantly higher in patients with heart failure (HF) compared with non-HF and control groups. Results of the distribution of IL-1β-31T/C genotypes and allele frequencies did not show any significant difference between the three groups. Serum levels of IL-1β were found to be higher among TT genotype than TC and CC genotype., Conclusion: IL-1β levels may be useful for the evaluation of diagnosis in acutely decompensated HF.