3,700 results on '"G. Guo"'
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2. Genetic analyses of blood β-hydroxybutyrate predicted from milk infrared spectra and its association with longevity and female reproductive traits in Holstein cattle
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W. Lou, H. Zhang, H. Luo, Z. Chen, R. Shi, X. Guo, Y. Zou, L. Liu, L.F. Brito, G. Guo, and Y. Wang
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β-hydroxybutyrate ,Chinese Holstein ,metabolic disease ,random regression model ,Dairy processing. Dairy products ,SF250.5-275 ,Dairying ,SF221-250 - Abstract
ABSTRACT: Ketosis is one of the most prevalent and complex metabolic disorders in high-producing dairy cows and usually detected through analyses of β-hydroxybutyrate (BHB) concentration in blood. Our main objectives were to evaluate genetic parameters for blood BHB predicted based on Fourier-transform mid-infrared spectra from 5 to 305 d in milk, and estimate the genetic relationships of blood BHB with 7 reproduction traits and 6 longevity traits in Holstein cattle. Predicted blood BHB records of 11,609 Holstein cows (after quality control) were collected from 2016 to 2019 and used to derive 4 traits based on parity number, including predicted blood BHB in all parities (BHBp), parity 1 (BHB1), parity 2 (BHB2), and parity 3+ (BHB3). Single- and multitrait repeatability models were used for estimating genetic parameters for the 4 BHB traits. Random regression test-day models implemented via Bayesian inference were used to evaluate the daily genetic feature of BHB variability. In addition, genetic correlations were calculated for the 4 BHB traits with reproduction and longevity traits. The heritability estimates of BHBp, BHB1, BHB2, and BHB3 ranged from 0.100 ± 0.026 (± standard error) to 0.131 ± 0.023. The BHB in parities 1 to 3+ were highly genetically correlated and ranged from 0.788 (BHB1 and BHB2) to 0.911 (BHB1 and BHB3). The daily heritability of BHBp ranged from 0.069 to 0.195, higher for the early and lower for the later lactation periods. A similar trend was observed for BHB1, BHB2, and BHB3. There are low direct genetic correlations between BHBp and selected reproductive performance and longevity traits, which ranged from −0.168 ± 0.019 (BHBp and production life) to 0.157 ± 0.019 (BHBp and age at first calving) for the early lactation stage (5 to 65 d). These direct genetic correlations indicate that cows with higher BHBp (greater likelihood of having ketosis) in blood usually have shorter production life (−0.168 ± 0.019). Cows with higher fertility and postpartum recovery, such as younger age at first calving (0.157 ± 0.019) and shorter interval from calving to first insemination in heifer (0.111 ± 0.006), usually have lower BHB concentration in the blood. Furthermore, the direct genetic correlations change across parity and lactation stage. In general, our results suggest that selection for lower predicted BHB in early lactation could be an efficient strategy for reducing the incidence of ketosis as well as indirectly improving reproductive and longevity performance in Holstein cattle.
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- 2022
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3. AN INDOOR POSITIONING SYSTEM BASED ON COMBINED AUDIO CHIRP/MEMS/FLOOR MAP: PERFORMANCE ANALYSIS OF KEPLER A100
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L. Huang, R. Chen, F. Ye, Z. Liu, Z. Li, S. Xu, G. Guo, and L. Qian
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Technology ,Engineering (General). Civil engineering (General) ,TA1-2040 ,Applied optics. Photonics ,TA1501-1820 - Abstract
In recent years, audio positioning technology has been more favoured because it is not only highly accurate but also universally applicable to the mass users. In line with this trend, a chip dedicated to indoor positioning, the Kepler A100, has been released lately, which ranges by estimating the arrival time of the audio chirp. As with radio ranging techniques, sound-based ranging methods is subject to significant observation errors due to Non-Line-Of-Sight (NLOS) or multi-path effects, while Pedestrian Dead Reckoning (PDR) based on inertial data have the disadvantage of error accumulation. Both make localization challenging. In this paper, the ranging performance of the Kepler A100 chip is evaluated and experiments are conducted in two typical indoor scenarios to verify the stability and sub-metre accuracy of the ranging results. Meanwhile, this paper implements an indoor positioning system combining audio chirp/Micro-Electro-Mechanical Systems (MEMS)/floor map based on particle filtering algorithm. A new mapping constraint method is applied in the system, which can effectively constrain the particles in a reasonable space. Experiments are conducted in two complex office environments and the results show that the error of the proposed algorithm is about 0.65m in 95% of cases, a reduction of more than 40% compared to only-PDR or only-audio. The effectiveness and stability of the method is demonstrated.
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- 2022
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4. VEHICLE POSITIONING IN UNDERGROUND SPACE USING A SMART PHONE
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L. Li, Q. Huang, K. Xu, G. Guo, and R. Chen
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Technology ,Engineering (General). Civil engineering (General) ,TA1-2040 ,Applied optics. Photonics ,TA1501-1820 - Abstract
Smartphones is a good choice for vehicle navigation since many navigation sensors are built-in with low cost advantage. However, it cannot provide reliable positioning information in underground space since GNSS is not available and IMU drift quickly. In this manuscript, a mixed navigation scheme for smartphone consumer is presented. It combines GNSS, INS, Non-Holonomic Constraint (NHC) and Bluetooth Low Energy (BLE) to provide reliable seamless navigation in both outdoors and underground. Some important problems including smartphone boresight misalignment, HNC level arm, GNSS and BLE time lag are discussed in the manuscript. The testing results show 3.1% /D horizontal positioning error in tunnel in INS/NHC positioning mode, and approximately 1 meter accuracy in underground parking garage in INS/NHC/BLE mode.
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- 2022
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5. Automated annotation and visualisation of high-resolution spatial proteomic mass spectrometry imaging data using HIT-MAP
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G. Guo, M. Papanicolaou, N. J. Demarais, Z. Wang, K. L. Schey, P. Timpson, T. R. Cox, and A. C. Grey
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Science - Abstract
MALDI-mass spectrometry imaging (MSI) can reveal the distribution of proteins in tissues but tools for protein identification and annotation are sparse. Here, the authors develop an open-source bioinformatic workflow for false discovery rate-controlled protein annotation and spatial mapping from MALDI-MSI data.
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- 2021
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6. Land subsidence due to groundwater pumping: hazard probability assessment through the combination of Bayesian model and fuzzy set theory
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H. Li, L. Zhu, G. Guo, Y. Zhang, Z. Dai, X. Li, L. Chang, and P. Teatini
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Environmental technology. Sanitary engineering ,TD1-1066 ,Geography. Anthropology. Recreation ,Environmental sciences ,GE1-350 ,Geology ,QE1-996.5 - Abstract
Land subsidence caused by groundwater overpumping threatens the sustainable development in Beijing. Hazard assessments of land subsidence can provide early warning information to improve prevention measures. However, uncertainty and fuzziness are the major issues during hazard assessments of land subsidence. We propose a method that integrates fuzzy set theory and weighted Bayesian model (FWBM) to evaluate the hazard probability of land subsidence measured by Interferometric Synthetic Aperture Radar (InSAR) technology. The model is structured as a directed acyclic graph. The hazard probability distribution of each factor triggering land subsidence is determined using Bayes' theorem. Fuzzification of the factor significance reduces the ambiguity of the relationship between the factors and subsidence. The probability of land subsidence hazard under multiple factors is then calculated with the FWBM. The subsidence time series obtained by InSAR is used to infer the updated posterior probability. The upper and middle parts of the Chaobai River alluvial fan are taken as a case-study site, which locates the first large-scale emergency groundwater resource region in the Beijing plain. The results show that rates of groundwater level decrease more than 1 m yr−1 in the confined and unconfined aquifers, with cumulative thicknesses of the compressible sediments between 160 and 170 m and Quaternary thicknesses between 400 and 500 m, yielding maximum hazard probabilities of 0.65, 0.68, 0.32, and 0.35, respectively. The overall hazard probability of land subsidence in the study area decreased from 51.3 % to 28.3 % between 2003 and 2017 due to lower rates of groundwater level decrease. This study provides useful insights for decision makers to select different approaches for land subsidence prevention.
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- 2021
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7. Branched-chain volatile fatty acids and folic acid accelerated the growth of Holstein dairy calves by stimulating nutrient digestion and rumen metabolism
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Y.R. Liu, H.S. Du, Z.Z. Wu, C. Wang, Q. Liu, G. Guo, W.J. Huo, Y.L. Zhang, C.X. Pei, and S.L. Zhang
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nutrient digestibility ,ruminal microflora ,cellulolytic rumen bacteria ,microbial enzyme activity ,microbial protein ,Animal culture ,SF1-1100 - Abstract
The combined addition of branched-chain volatile fatty acids (BCVFAs) and folic acid (FA) could improve growth performance and nutrient utilization by stimulating ruminal microbial growth and enzyme activity. This study was conducted to evaluate the effects of BCVFA and FA addition on growth performance, ruminal fermentation, nutrient digestibility, microbial enzyme activity, microflora and excretion of urinary purine derivatives (PDs) in calves. Thirty-six Chinese Holstein weaned calves (60 ± 5.4 days of age and 107 ± 4.7 kg of BW) were assigned to one of four groups in a randomized block design. Treatments were control (without additives), FA (with 10 mg FA/kg dietary DM), BCVFA (with 5 g BCVFA/kg dietary DM) and the combined addition of FA and BCVFA (10 mg/kg DM of FA and 5 g/kg DM of BCVFA). Supplements were hand-mixed into the top one-third of total mixed ration. Dietary concentrate to maize silage ratio was 50 : 50 on a DM basis. Dietary BCVFA or FA addition did not affect dry matter intake but increased average daily gain (ADG) and feed conversion efficiency. Ruminal pH and ammonia N were lower, and total volatile fatty acids (VFAs) concentration was higher for BCVFA or FA addition than for control. Dietary BCVFA or FA addition did not affect acetate proportion but decreased propionate proportion and increased acetate to propionate ratio. Total tract digestibility of DM, organic matter, CP and NDF was higher for BCVFA or FA addition than for control. Dietary BCVFA or FA addition increased activity of carboxymethyl cellulase and cellobiase, population of total bacteria, fungi, Ruminococcus albus, R. flavefaciens, Fibrobacter succinogenes and Prevotella ruminicola as well as total PD excretion. Ruminal xylanase, pectinase and protease activity and Butyrivibrio fibrisolvens population were increased by BCVFA addition, whereas population of protozoa and methanogens was increased by FA addition. The BCVFA × FA interaction was significant for acetate to propionate ratio, cellobiase activity and total PD excretion, and these variables increased more with FA addition in diet without BCVFA than in diet with BCVFA. The data indicated that supplementation with BCVFA or FA increased ADG, nutrient digestibility, ruminal total VFA concentration and microbial protein synthesis by stimulating ruminal microbial growth and enzyme activity in calves.
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- 2020
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8. Effects of sodium selenite and coated sodium selenite on lactation performance, total tract nutrient digestion and rumen fermentation in Holstein dairy cows
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Z.D. Zhang, C. Wang, H.S. Du, Q. Liu, G. Guo, W.J. Huo, J. Zhang, Y.L. Zhang, C.X. Pei, and S.L. Zhang
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selenium ,milk performance ,nutrient digestibility ,ruminal microbiota ,microbial enzymatic activity ,Animal culture ,SF1-1100 - Abstract
Se can enhance lactation performance by improving nutrient utilization and antioxidant status. However, sodium selenite (SS) can be reduced to non-absorbable elemental Se in the rumen, thereby reducing the intestinal availability of Se. The study investigated the impacts of SS and coated SS (CSS) supplementation on lactation performance, nutrient digestibility, ruminal fermentation and microbiota in dairy cows. Sixty multiparous Holstein dairy cows were blocked by parity, daily milk yield and days in milk and randomly assigned to five treatments: control, SS addition (0.3 mg Se/kg DM as SS addition) or CSS addition (0.1, 0.2 and 0.3 mg Se/kg DM as CSS addition for low CSS (LCSS), medium CSS (MCSS) and high CSS (HCSS), respectively). Experiment period was 110 days with 20 days of adaptation and 90 days of sample collection. Dry matter intake was higher for MCSS and HCSS compared with control. Yields of milk, milk fat and milk protein and feed efficiency were higher for MCSS and HCSS than for control, SS and LCSS. Digestibility of DM and organic matter was highest for CSS addition, followed by SS addition and then control. Digestibility of CP was higher for MCSS and HCSS than for control, SS and LCSS. Higher digestibility of ether extract, NDF and ADF was observed for SS or CSS addition. Ruminal pH decreased with dietary Se addition. Acetate to propionate ratio and ammonia N were lower, and total volatile fatty acids (VFAs) concentration was greater for SS, MCSS and HCSS than control. Ruminal H ion concentration was highest for MCSS and HCSS and lowest for control. Activities of cellobiase, carboxymethyl-cellulase, xylanase and protease and copies of total bacteria, fungi, Ruminococcus flavefaciens, Fibrobacter succinogenes and Ruminococcus amylophilus increased with SS or CSS addition. Activity of α-amylase, copies of protozoa, Ruminococcus albus and Butyrivibrio fibrisolvens and serum glucose, total protein, albumin and glutathione peroxidase were higher for SS, MCSS and HCSS than for control and LCSS. Dietary SS or CSS supplementation elevated blood Se concentration and total antioxidant capacity activity. The data implied that milk yield was elevated due to the increase in total tract nutrient digestibility, total VFA concentration and microorganism population with 0.2 or 0.3 mg Se/kg DM from CSS supplementation in dairy cows. Compared with SS, HCSS addition was more efficient in promoting lactation performance of dairy cows.
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- 2020
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9. Effects of guanidinoacetic acid supplementation on growth performance, nutrient digestion, rumen fermentation and blood metabolites in Angus bulls
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S.Y. Li, C. Wang, Z.Z. Wu, Q. Liu, G. Guo, W.J. Huo, J. Zhang, L. Chen, Y.L. Zhang, C.X. Pei, and S.L. Zhang
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guanidinoacetate ,weight gain ,nutrient digestibility ,rumen microflora ,blood indicators ,Animal culture ,SF1-1100 - Abstract
Guanidinoacetic acid (GAA) can improve the growth performance of bulls. This study investigated the influences of GAA addition on growth, nutrient digestion, ruminal fermentation and serum metabolites in bulls. Forty-eight Angus bulls were randomly allocated to experimental treatments, that is, control, low-GAA (LGAA), medium-GAA (MGAA) and high-GAA (HGAA), with GAA supplementation at 0, 0.3, 0.6 and 0.9 g/kg DM, respectively. Bulls were fed a basal diet containing 500 g/kg DM concentrate and 500 g/kg DM roughage. The experimental period was 104 days, with 14 days for adaptation and 90 days for data collection. Bulls in the MGAA and HGAA groups had higher DM intake and average daily gain than bulls in the LGAA and control groups. The feed conversion ratio was lowest in MGAA and highest in the control. Bulls receiving 0.9 g/kg DM GAA addition had higher digestibility of DM, organic matter, NDF and ADF than bulls in other groups. The digestibility of CP was higher for HGAA than for LGAA and control. The ruminal pH was lower for MGAA, and the total volatile fatty acid concentration was greater for MGAA and HGAA than for the control. The acetate proportion and acetate-to-propionate ratio were lower for MGAA than for LGAA and control. The propionate proportion was higher for MGAA than for control. Bulls receiving GAA addition showed decreased ruminal ammonia N. Bulls in MGAA and HGAA had higher cellobiase, pectinase and protease activities and Butyrivibrio fibrisolvens, Prevotella ruminicola and Ruminobacter amylophilus populations than bulls in LGAA and control. However, the total protozoan population was lower for MGAA and HGAA than for LGAA and control. The total bacterial and Ruminococcus flavefaciens populations increased with GAA addition. The blood level of creatine was higher for HGAA, and the activity of l-arginine glycine amidine transferase was lower for MGAA and HGAA, than for control. The blood activity of guanidine acetate N-methyltransferase and the level of folate decreased in the GAA addition groups. The results indicated that dietary addition of 0.6 or 0.9 g/kg DM GAA improved growth performance, nutrient digestion and ruminal fermentation in bulls.
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- 2020
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10. Effects of isovalerate supplements on morphology and functional gene expression of rumen mucosa in pre- and post-weaning dairy calves
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Q. Liu, C. Wang, G. Guo, W.J. Huo, Y.L. Zhang, C.X. Pei, S.L. Zhang, and H. Wang
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isovalerate ,rumen development ,morphology ,functional gene ,dairy calves ,Animal culture ,SF1-1100 - Abstract
Isovalerate supplements could stimulate rumen development by improving morphology and function of rumen mucosa, and then promote the growth of calves. This study was done to evaluate the effects of isovalerate supplements on morphology and functional gene expression of rumen mucosa in dairy calves. In total, 48 Chinese Holstein male calves with 15 days of age and 45.1±0.36 kg of BW were randomly assigned to four groups. The treatments were: control, low-isovalerate, moderate-isovalerate and high-isovalerate with 0, 3, 6 and 9 g isovalerate per calf per day, respectively. Supplementary isovalerate was hand-mixed into milk in pre-weaning calves and into concentrate portion in post-weaning calves. The study consisted of a 15-day-adaptation period and a 60-day-sampling period. Calves were weaned at 60 days of age. Three calves were slaughtered from each of the four treatments at 30, 60 and 90 days of age. The weight of body and stomach were measured, samples of ruminal tissues and blood were analyzed. Total stomach weight, total stomach to BW ratio, rumen wall and keratinized layer thickness, serum growth hormone and IGF-1 for both pre- and post-weaning calves increased linearly with increasing isovalerate supplements. Rumen to total stomach weight ratio, the length and width of rumen papillae, and serum β-hydroxybutyrate increased linearly for post-weaning calves. However, abomasum weight to total stomach weight ratio decreased linearly for both pre- and post-weaning calves. The relative messenger RNA expression for growth hormone receptor, IGF-1 receptor and 3-hydroxy-3-methylglutaryl-CoA synthase 1 in rumen mucosa increased linearly for post-weaning calves. Our results suggested that isovalerate supplements promoted rumen development in a dose-dependent manner. The optimum dose was 6.0 g isovalerate per calf per day.
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- 2018
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11. Effects of branched-chain volatile fatty acids on lactation performance and mRNA expression of genes related to fatty acid synthesis in mammary gland of dairy cows
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Q. Liu, C. Wang, G. Guo, W.J. Huo, S.L. Zhang, C.X. Pei, Y.L. Zhang, and H. Wang
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branched-chain volatile fatty acids ,ruminal fermentation ,nutrient digestibility ,milk fat synthesis ,gene expression ,Animal culture ,SF1-1100 - Abstract
Branched-chain volatile fatty acids (BCVFA) supplements could promote lactation performance and milk quality by improving ruminal fermentation and milk fatty acid synthesis. This study was conducted to evaluate the effects of BCVFA supplementation on milk performance, ruminal fermentation, nutrient digestibility and mRNA expression of genes related to fatty acid synthesis in mammary gland of dairy cows. A total of 36 multiparous Chinese Holstein cows averaging 606±4.7 kg of BW, 65±5.2 day in milk (DIM) with daily milk production of 30.6±0.72 kg were assigned to one of four groups blocked by lactation number, milk yield and DIM. The treatments were control, low-BCVFA (LBCVFA), medium-BCVFA (MBCVFA) and high-BCVFA (HBCVFA) with 0, 30, 60 and 90 g BCVFA per cow per day, respectively. Experimental periods were 105 days with 15 days of adaptation and 90 days of data collection. Dry matter (DM) intake tended to increase, but BW changes were similar among treatments. Yields of actual milk, 4% fat corrected milk, milk fat and true protein linearly increased, but feed conversion ratio (FCR) linearly decreased with increasing BCVFA supplementation. Milk fat content linearly increased, but true protein content tended to increase. Contents of C4:0, C6:0, C8:0, C10:0, C12:0, C14:0 and C15:0 fatty acids in milk fat linearly increased, whereas other fatty acids were not affected with increasing BCVFA supplementation. Ruminal pH, ammonia N concentration and propionate molar proportion linearly decreased, but total VFA production and molar proportions of acetate and butyrate linearly increased with increasing BCVFA supplementation. Consequently, acetate to propionate ratios linearly increased. Digestibilities of DM, organic matter, CP, NDF and ADF also linearly increased. In addition, mRNA expressions of peroxisome proliferator-activated receptor γ, sterol regulatory element-binding factor 1 and fatty acid-binding protein 3 linearly increased, mRNA expressions of acetyl-coenzyme A carboxylase-α, fatty acid synthase and stearoyl-CoA desaturase quadratically increased. However, lipoprotein lipase mRNA expression was not affected by treatments. The results indicated that lactation performance and milk fat synthesis increased with BCVFA supplementation by improving ruminal fermentation, nutrient digestibility and mRNA expressions of genes related to milk fat synthesis.
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- 2018
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12. Selection of reference genes for quantitative real-time PCR in Casuarina equisetifolia under salt stress
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C. Fan, Z. Qiu, B. Zeng, Y. Liu, X. Li, and G. Guo
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act ,ef1a ,dnaj ,gapdh ,u2 ,ubc ,Biology (General) ,QH301-705.5 ,Plant ecology ,QK900-989 - Abstract
Real time quantitative PCR (qPCR) is widely used in gene expression analysis for its accuracy and sensitivity. Reference genes serving as endogenous controls are necessary for gene normalization. In order to select an appropriate reference gene to normalize gene expression in Casuarina equisetifolia under salt stress, 10 potential reference genes were evaluated using real time qPCR in the leaves and roots of plants grown under different NaCl concentrations and treatment durations. GeNorm, NormFinder, and BestKeeper analyses reveal that elongation factor 1-alpha (EF1α) and ubiquitin-conjugating enzyme E2 (UBC) were the most appropriate reference genes for real time qPCR under salt stress. However, β-tubulin (βTUB) and actin 7, which were widely used as reference genes in other plant species, were not always stably expressed. The combination of EF1α, UBC, uncharacterized protein 2, DNAJ homolog subfamily A member 2, and glyceraldehyde-3-phosphate dehydrogenase should be ideal reference genes for normalizing gene expression data in all samples under salt stress. It indicates the need for reference gene selection for normalizing gene expression in C. equisetifolia. In addition, the suitability of reference genes selected was confirmed by validating the expression of WRKY29-like and expansin-like B1. The results enable analysis of salt response mechanism and gene expression in C. equisetifolia.
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- 2017
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13. Modeling 3-D permeability distribution in alluvial fans using facies architecture and geophysical acquisitions
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L. Zhu, H. Gong, Z. Dai, G. Guo, and P. Teatini
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Technology ,Environmental technology. Sanitary engineering ,TD1-1066 ,Geography. Anthropology. Recreation ,Environmental sciences ,GE1-350 - Abstract
Alluvial fans are highly heterogeneous in hydraulic properties due to complex depositional processes, which make it difficult to characterize the spatial distribution of the hydraulic conductivity (K). An original methodology is developed to identify the spatial statistical parameters (mean, variance, correlation range) of the hydraulic conductivity in a three-dimensional (3-D) setting by using geological and geophysical data. More specifically, a large number of inexpensive vertical electric soundings are integrated with a facies model developed from borehole lithologic data to simulate the log10(K) continuous distributions in multiple-zone heterogeneous alluvial megafans. The Chaobai River alluvial fan in the Beijing Plain, China, is used as an example to test the proposed approach. Due to the non-stationary property of the K distribution in the alluvial fan, a multiple-zone parameterization approach is applied to analyze the conductivity statistical properties of different hydrofacies in the various zones. The composite variance in each zone is computed to describe the evolution of the conductivity along the flow direction. Consistently with the scales of the sedimentary transport energy, the results show that conductivity variances of fine sand, medium-coarse sand, and gravel decrease from the upper (zone 1) to the lower (zone 3) portion along the flow direction. In zone 1, sediments were moved by higher-energy flooding, which induces poor sorting and larger conductivity variances. The composite variance confirms this feature with statistically different facies from zone 1 to zone 3. The results of this study provide insights to improve our understanding on conductivity heterogeneity and a method for characterizing the spatial distribution of K in alluvial fans.
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- 2017
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14. Effects of isobutyrate supplementation in pre- and post-weaned dairy calves diet on growth performance, rumen development, blood metabolites and hormone secretion
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C. Wang, Q. Liu, Y.L. Zhang, C.X. Pei, S.L. Zhang, G. Guo, W.J. Huo, W.Z. Yang, and H. Wang
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isobutyrate ,growth performance ,rumen development ,blood parameter ,dairy calves ,Animal culture ,SF1-1100 - Abstract
Isobutyrate supplements could improve rumen development by increasing ruminal fermentation products, especially butyrate, and then promote the growth performance of calves. The objective of this study was to evaluate the effects of isobutyrate supplementation on growth performance, rumen development, blood metabolites and hormone secretion in pre- and post-weaned dairy calves. In total, 56 Chinese Holstein male calves with 30 days of age and 72.9±1.43 kg of BW, blocked by days of age and BW, were assigned to four groups in a randomized block design. The treatments were as follows: control, low-isobutyrate, moderate-isobutyrate and high-isobutyrate with 0, 0.03, 0.06 and 0.09 g isobutyrate/kg BW per calf per day, respectively. Supplemental isobutyrate was hand-mixed into milk of pre-weaned calves and the concentrate portion of post-weaned calves. The study consisted of 10 days of an adaptation period and a 50-day sampling period. Calves were weaned at 60 days of age. Seven calves were chosen from each treatment at random and slaughtered at 45 and 90 days of age. BW, dry matter (DM) intake and stomach weight were measured, samples of ruminal tissues and blood were determined. For pre- and post-weaned calves, DM intake and average daily gain increased linearly (P
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- 2017
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15. Spatial-temporal variation of groundwater and land subsidence evolution in Beijing area
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K. Lei, Y. Luo, B. Chen, M. Guo, G. Guo, Y. Yang, and R. Wang
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Environmental sciences ,GE1-350 ,Geology ,QE1-996.5 - Abstract
Precipitation is the main recharge source of groundwater in the plain of Beijing, China. Rapid expansion of urbanization has resulted in increased built-up area and decreased amount of effective recharge of precipitation to groundwater, indirectly leading to the long-term over-exploitation of groundwater, and induced regional land subsidence. Based on the combination of meteorological data, groundwater level data, interferometric synthetic aperture radar (InSAR; specifically persistent scatterer interferometry, PSI), geographic information system (GIS) spatial analysis method and rainfall recharge theory, this paper presents a systematic analysis of spatial-temporal variation of groundwater level and land subsidence evolution. Results show that rainfall has been decreasing annually, while the exploitation of groundwater is increasing and the groundwater level is declining, which is has caused the formation and evolution of land subsidence. Seasonal and interannual variations exist in the evolution of land subsidence; the subsidence is uneven in both spatial and temporal distribution. In 2011, at the center of mapped subsidence the subsidence rate was greater than 120 mm a−1. The results revealed good correlation between the spatial distribution of groundwater level declines and subsidence. The research results show that it is beneficial to measure the evolution of land subsidence to dynamic variations of groundwater levels by combining InSAR or PSI, groundwater-level data, and GIS. This apprpach provides improved information for environmental and hydrogeologic research and a scientific basis for regional land subsidence control.
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- 2015
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16. Pathway and Network Embedding Methods for Prioritizing Psychiatric Drugs.
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Yash Pershad, Margaret G. Guo, and Russ B. Altman
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- 2020
17. A Literature-Based Knowledge Graph Embedding Method for Identifying Drug RepurposingOpportunities in Rare Diseases.
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Daniel N. Sosa, Alexander Derry, Margaret G. Guo, Eric Wei, Connor Brinton, and Russ B. Altman
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- 2020
18. Challenges and opportunities in network-based solutions for biological questions.
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Margaret G. Guo, Daniel N. Sosa, and Russ B. Altman
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- 2022
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19. DESIGN OF COOPERATIVE UPDATE MECHANISM OF NATIONAL RESOURCES INVESTIGATION AND BASIC SURVEYING AND MAPPING
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C. Li, F. J. Luo, K. Yang, and R. G. Guo
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Technology ,Engineering (General). Civil engineering (General) ,TA1-2040 ,Applied optics. Photonics ,TA1501-1820 - Abstract
National resources investigation and basic surveying and mapping are two important tasks of the surveying and mapping department, and they are similar in production organization and technology realization. In the process of operation, both of them need to carry out internal collection, base map production, field verification and so on. It is operationally feasible to carry out cooperative production of national resources investigation and basic surveying and mapping. From the perspective of technical process and method, both of them are carried out by combination internal and field work. Firstly, based on remote sensing images and thematic geographic data, the internal work will perform image interpretation. Then, the field verification will be carried out to make judgments and adjustments. Finally, the results of the field verification will be transferred back to the internal work, and the data will be further edited and organized in the internal work to obtain the final data.This paper analyzes the technical methods and workflow of the cooperative update mechanism of national resources investigation and basic surveying and mapping. It will enable one-time acquisition of data needed for the national resources investigation and basic surveying and mapping. It is conducive to unifying the classification system, technical standards, survey methods, establishing a natural resource data service system, and improving the natural resource data sharing working mechanism. Realize the overall control of the land space, solve the contradictory problems such as multiple doors, uneven thickness, repeated crossover, etc., advance data integration and deep development and utilization by using big data technology and data analysis model.
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- 2020
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20. Is 3D frequency-domain FWI of full-azimuth/long-offset OBN data feasible? The Gorgon data FWI case study
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S. Operto, P. Amestoy, H. Aghamiry, S. Beller, A. Buttari, L. Combe, V. Dolean, M. Gerest, G. Guo, P. Jolivet, J.-Y. L'Excellent, F. Mamfoumbi, T. Mary, C. Puglisi, A. Ribodetti, and P.-H. Tournier
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Geophysics ,Geology - Abstract
Frequency-domain full-waveform inversion (FWI) is potentially amenable to efficient processing of full-azimuth long-offset stationary-recording seabed acquisition carried out with a sparse layout of ocean-bottom nodes (OBNs) and broadband sources because the inversion can be performed with a few discrete frequencies. However, computing the solution of the forward (boundary-value) problem efficiently in the frequency domain with linear algebra solvers remains a challenge for large computational domains involving tens to hundreds of millions of parameters. We illustrate the feasibility of 3D frequency-domain FWI with a subset of the 2015/2016 Gorgon OBN data set in the North West Shelf, Australia. We solve the forward problem with the massively parallel multifrontal direct solver MUMPS, which includes four key features to reach high computational efficiency: an efficient parallelism combining message-passing interface and multithreading, block low-rank compression, mixed-precision arithmetic, and efficient processing of sparse sources. The Gorgon subdata set involves 650 OBNs that are processed as reciprocal sources and 400,000 sources. Monoparameter FWI for vertical wavespeed is performed in the viscoacoustic vertically transverse isotropic approximation with a classical frequency continuation approach proceeding from a starting frequency of 1.7 Hz to a final frequency of 13 Hz. The target covers an area ranging from 260 km2 (frequency ≥ 8.5 Hz) to 705 km2 (frequency ≤ 8.5 Hz) for a maximum depth of 8 km. Compared to the starting model, FWI dramatically improves the reconstruction of the bounding faults of the Gorgon horst at reservoir depths as well as several intrahorst faults and several horizons of the Mungaroo Formation down to a depth of 7 km. Seismic modeling reveals a good kinematic agreement between recorded and simulated data, but amplitude mismatches between the recorded and simulated reflection from the reservoir suggest elastic effects. Therefore, future works involve multiparameter reconstruction for density and attenuation before considering elastic FWI from hydrophone and geophone data.
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- 2023
21. Single-Cell and Spatial Transcriptomic Analysis of Human Skin Delineates Intercellular Communication and Pathogenic Cells
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Kim Thrane, Mårten C.G. Winge, Hongyu Wang, Larry Chen, Margaret G. Guo, Alma Andersson, Xesús M. Abalo, Xue Yang, Daniel S. Kim, Sophia K. Longo, Brian Y. Soong, Jordan M. Meyers, David L. Reynolds, Aaron McGeever, Deniz Demircioglu, Dan Hasson, Reza Mirzazadeh, Adam J. Rubin, Gordon H. Bae, Jim Karkanias, Kerri Rieger, Joakim Lundeberg, and Andrew L. Ji
- Subjects
Cell Biology ,Dermatology ,Molecular Biology ,Biochemistry - Published
- 2023
22. Suppression of Lung Nitrogen Mustard-induced Pulmonary Fibrosis, Oxidative Stress and Inflammatory Macrophage Activation by the Farnesoid X Receptor Agonist, Obeticholic Acid
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J. Meshanni, R. Sun, K. Vayas, G. Guo, A. Gow, J. Laskin, and D.L. Laskin
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- 2023
23. Clustering of capnogram features to track state transitions during procedural sedation.
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Rebecca J. Mieloszyk, Margaret G. Guo, George C. Verghese, Gary Andolfatto, Thomas Heldt, and Baruch S. Krauss
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- 2015
- Full Text
- View/download PDF
24. Enhancement effects of distiller's dried grains as reducing agents on the kinetics and leaching of pyrolusite from manganese ore
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Liu, D. (Dongjie), Gao, L. (Lei), Chen, G. (Guo), Zhou, J. (Junwen), Guo, S. (Shenghui), Omran, M. (Mamdouh), and Chen, J. (Jin)
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Biomaterials ,Leaching kinetics ,Hydrometallurgical ,Distiller's dried grains ,Manganese leaching efficiency ,Metals and Alloys ,Ceramics and Composites ,Pyrolusite ,Surfaces, Coatings and Films - Abstract
To solve the problem of environmental pollution, Distiller’s dried grains (DDGS), a biomass, is used as a clean reducing agent for the leaching process of pyrolusite. Experimental results have shown that the leaching rate of manganese can reach 92.1% with the optimized conditions including a sulfuric acid concentration of 3.5 mol/L, a DDGS to pyrolusite ratio of 0.4, a liquid–solid ratio of 3 mL/g, a temperature of 363K, a time of 3 h, and a rotation speed of 400 rpm. This article explored the mechanism of the entire leaching process: the crude fiber in DDGS is hydrolyzed into reducing sugars, and the MnO₂ in pyrolusite undergoes an oxidation–reduction reaction to generate Mn²⁺ and studied the kinetics of the leaching process following the unreacted shrinkage nuclear reaction model controlled by the surface chemical reaction (\(1-(1-X)^{1/3}=\text{kt}\)). The equation of leaching kinetics is \(1−1-\text{X}^{\frac{1}{3}} = 3738.06 \cdot [\text{H}_{2}\text{SO}_{4}]^{0.57} \cdot \left[\frac{L}{S}\right]^{0.78} \cdot \left[\frac{DDGS}{\text{pyrolusite}}\right]^{0.25} \cdot [rpm]^{0.09} \cdot \exp(-48.448/(RT)\) This work provides a green and effective leaching process for the leaching of pyrolusite.
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- 2022
25. Design and Experiment of 1 THz Slow Wave Structure Fabricated by Nano-CNC Technology
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R. Yang, J. Xu, L. Yue, P. Yin, J. Luo, H. Yin, G. Zhao, G. Guo, S. Yu, X. Niu, M. Hu, D. Liu, W. Wang, W. Liu, D. Li, and Y. Wei
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Electrical and Electronic Engineering ,Electronic, Optical and Magnetic Materials - Published
- 2022
26. Effect of microwave drying technology on drying kinetics of Al₂O₃–ZrO₂ composite ceramic powder
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Zhou, J. (Ju), Cao, W. (Wei), Zhang, Y. (Yanqiong), Omran, M. (Mamdouh), Chen, G. (Guo), Gao, L. (Lei), Zhang, F. (Fan), Tang, J. (Ju), Zhou, J. (Ju), Cao, W. (Wei), Zhang, Y. (Yanqiong), Omran, M. (Mamdouh), Chen, G. (Guo), Gao, L. (Lei), Zhang, F. (Fan), and Tang, J. (Ju)
- Abstract
Al₂O₃–ZrO₂ composite ceramic is a significant structural material and functional material, and the preparation of high-quality Al₂O₃–ZrO₂ powder is a key step to meeting practical application requirements. The major factor affecting the quality of Al₂O₃–ZrO₂ powder is the drying effect. This paper uses modern microwave drying technology to dry Al₂O₃–ZrO₂ powder. The result was indicative that the average drying rate increases with initial moisture content, initial mass, and microwave heating power. Four dynamic models were applied to fit the empirical data of Al₂O₃–ZrO₂ powder under different pretreatment conditions, the Modified Page model can precisely delineate the Al₂O₃–ZrO₂ microwave drying procedure. To evaluate the changes in samples before and post-drying, the specimens were characterized by Fourier transform infrared spectroscopy. These results demonstrate that microwaves can accelerate the drying of Al₂O₃–ZrO₂ and improve its dispersion. Fick’s second law calculates the effective diffusion coefficient. When the initial moisture content of Al₂O₃–ZrO₂ was 5.6%, the microwave heating power is 560 W, and the initial quality is 15 g, the effective diffusion coefficient of Al₂O₃–ZrO₂ is 0.006361 m²/s. Based on the relevance of the microwave power and activating energy, the activating energy of microwave drying Al₂O₃–ZrO₂ was calculated, which is −34.80 g/W. This paper provides basic study data and theory instructions for microwave drying technology in drying Al₂O₃–ZrO₂ even the drying process in green metallurgy.
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- 2023
27. Microwave efficient extraction of manganese from low-grade pyrolusite by pyrite reduction acid leaching process
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Du, J. (Jinjia), Zhang, Y. (Yanqiong), Lu, J. (Jiajia), Gao, L. (Lei), Guo, S. (Shenghui), Omran, M. (Mamdouh), Chen, J. (Jin), Chen, G. (Guo), Du, J. (Jinjia), Zhang, Y. (Yanqiong), Lu, J. (Jiajia), Gao, L. (Lei), Guo, S. (Shenghui), Omran, M. (Mamdouh), Chen, J. (Jin), and Chen, G. (Guo)
- Abstract
With the continuous economic and social development of China, the demand for pyrolusite has increased tremendously, accompanied by a decrease in high-grade pyrolusite (HGP). Thus, it is urgent to find viable alternatives, such as low-grade pyrolusite (LGP). Currently, a relatively mature process technology is a one-step acid leaching of manganese (Mn) from pyrolusite using pyrite (PY) as a reducing agent. While the method can achieve a relatively high leaching efficiency of Mn at atmospheric pressure, it requires a significant amount of time. To pursue maximum effectiveness and efficiency, here we applied microwave leaching technology to the one-step acid leaching process to the extraction of Mn from LGP, and PY as a reducing agent. The results showed that the leaching efficiency of Mn reached 96.2% at time = 150 min, agitation speed = 400 rpm, temperature = 363 K, acid concentration = 1.5 M, liquid-solid ratio = 10: 1 (mL: g), and SLGP-SPY- mass ratio = 10: 2. Furthermore, the kinetic analysis showed that the chemical reaction control model (1-(1-X)1/3 = kt) can be used to explain the mechanism of the microwave leaching process. Finally, according to the Arrhenius equation, the apparent activation energy (Ea) for the microwave leaching process was calculated as 44.8 kJ/mol. This work provides the preliminary theoretical and technical basis for recovering Mn from LGP. In summary, these results imply that LGP could be effectively utilized and developed by microwave heating technology in the future.
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- 2023
28. Research on the drying kinetics for the microwave drying of Y₂O₃–ZrO₂ ceramic powder
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Cao, W. (Wei), Zhou, J. (Ju), Ren, C. (Chunxiao), Omran, M. (Mamdouh), Gao, L. (Lei), Tang, J. (Ju), Zhang, F. (Fan), Chen, G. (Guo), Cao, W. (Wei), Zhou, J. (Ju), Ren, C. (Chunxiao), Omran, M. (Mamdouh), Gao, L. (Lei), Tang, J. (Ju), Zhang, F. (Fan), and Chen, G. (Guo)
- Abstract
Y₂O₃–ZrO₂ ceramic powder has emerged as a vital structural and functional material in ceramic applications owing to its remarkable performance including wear resistance, temperature resistance, and corrosion resistance. Agglomeration during the drying process is the other key issue that needs to be resolved, which improving the quality of zirconia powder becomes crucial in reducing industrial expenses. This study focuses on investigating the influence of modern microwave heating technology on the drying kinetics of Y₂O₃–ZrO₂ ceramic powder. The experimental results revealed that the average drying rate of Y₂O₃–ZrO₂ ceramic powder increased with sample water content, microwave heating power, and sample mass. Four kinetic fitting models, namely Page, Wang and Singh, Quadratic Model, and Modified Page, were employed to analyze the experimental data for Y₂O₃–ZrO₂ ceramic powder with a mass of 20 g, initial water content of 7.5%, and the microwave heating power is 480 W. Among these models, the Modified Page model demonstrated the best fit and effectively described the drying kinetics of Y₂O₃–ZrO₂ceramic powder. The Modified Page model successfully captured the kinetics across varying masses, microwave heating powers, and initial water content. FT-IR spectroscopy was employed to describe the material before and after microwave drying. The results exhibited a significant reduction in water molecule content in the Y₂O₃–ZrO₂ ceramic powder after microwave drying, thus confirming the high efficiency and rapidity of the microwave drying procedure. This research provides comprehensive experimental data and offers a theoretical foundation for the industrial application of microwave-enhanced drying of Y₂O₃–ZrO₂ ceramic powder.
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- 2023
29. Preparation of novel Ti–Y/ZrO₂ ceramic by two-step of mechanical alloying and microwave-assisted sintering process
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Zhang, Y. (Yanqiong), Zhou, J. (Ju), Ren, C. (Chunxiao), Omran, M. (Mamdouh), Tang, J. (Ju), Zhang, F. (Fan), Chen, G. (Guo), Zhang, Y. (Yanqiong), Zhou, J. (Ju), Ren, C. (Chunxiao), Omran, M. (Mamdouh), Tang, J. (Ju), Zhang, F. (Fan), and Chen, G. (Guo)
- Abstract
Zirconia composite ceramic materials are popular for their many excellent properties. In this study, nTi-3Y–ZrO₂ composite ceramics were produced by the mechanical alloying-microwave sintering method with different Ti-doping amounts and microwave sintering temperatures. The sample’s phase composition, stability rate, lattice parameters, micromorphology, relative density, and grain size are characterized. The results showed that when the sintering temperature is 1200 °C, the samples with different doping amounts are mainly mixed crystalline structures with tetragonal and cubic phases, and the stability rate remains above 90 %. As TiO₂ doping increases, the lattice parameters a(Å) and b(Å)first increase and then decrease, while the lattice parameter c (Å) shows an overall increasing trend. Raman data demonstrated that the increase in Ti content promoted the generation of tetragonal phase zirconia. The average grain size is 61.33 nm, 76.23 nm, 58.77 nm, 63.35 nm, and 68.99 nm, respectively. The increase in doping is also accompanied by a narrowing of the grain size distribution, which increases the sintering activity of the sample. In addition, the relative densities of the samples were 67.85 %, 73.94 %, 84.25 %, 84.87 %, and 77.54 %, respectively, showing a gradual increasing trend overall. When the microwave sintering temperature is 1200 °C, and the doping amount is 5Ti–3Y–92Zr, the performance of the sample is superior to other groups. The preparation of nTi-3Y–ZrO₂ composite ceramics can provide certain ideas for preparing ceramic materials with excellent performance in various aspects.
- Published
- 2023
30. Sodium selenite addition promotes the proliferation of bovine mammary epithelial cells through the Akt-mTOR signalling pathway
- Author
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J. Zhang, Y. Liu, L. Bu, Q. Liu, C. Pei, and G. Guo
- Subjects
Animal Science and Zoology ,Food Science - Published
- 2023
31. Fusion of HJ1B and ALOS PALSAR data for land cover classification using machine learning methods.
- Author
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Xin-Yun Wang, Y. G. Guo, J. He, and L. T. Du
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- 2016
- Full Text
- View/download PDF
32. New Method to Prepare the Lowest Eutectic Mixture of MTNP/DNTF and Its Properties
- Author
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Y. Kou, X.-L. Song, K.-G. Guo, and Y. Wang
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Fuel Technology ,Process Chemistry and Technology ,Mechanical Engineering ,General Chemical Engineering ,General Physics and Astronomy ,Energy Engineering and Power Technology ,General Chemistry - Published
- 2022
33. Numerical simulation investigation of drug deposition process during nasal administration with auxiliary airflow
- Author
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H.X. Ren, L.X. Zhang, G. Guo, Z.B. Tong, Z.Y. Li, Y. Zhang, and A.B. Yu
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General Chemical Engineering - Published
- 2023
34. Time Domain Full Waveform Inversion with Decomposed Gauss-Newton Hessian
- Author
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G. Guo, S. Operto, and H.S. Aghamiry
- Published
- 2023
35. 3D frequency-domain FWI of full-azimuth/long-offset OBN data - The Gorgon-data FWI case study
- Author
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S. Operto, P. Amestoy, H. Aghamiry, S. Beller, A. Buttari, L. Combe, V. Dolean, M. Gerest, G. Guo, P. Jolivet, J. L’Excellent, F. Mamfoumbi, T. Mary, C. Puglisi, A. Ribodetti, and P. Tournier
- Published
- 2023
36. Weighted Time-Domain Extended-Source Full Waveform Inversion with Layer Stripping
- Author
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G. Guo, S. Operto, H.S. Aghamiry, and A. Gholami
- Published
- 2023
37. Research on the tetragonal phase content and microstructure of microwave-assisted sintering Y-PSZ system doped Bi₂O₃
- Author
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Huang, W. (Weiwei), Lu, J. (Jiajia), Zhang, Y. (Yanqiong), Omran, M. (Mamdouh), Gao, L. (Lei), Chen, J. (Jin), and Chen, G. (Guo)
- Subjects
Doping amount ,Y-PSZ powders ,Tetragonal phase content ,Average particle size ,Microwave sintering - Abstract
Partially stabilized Y₂O₃–ZrO₂ (Y-PSZ) is often used as a material in the field of oxygen sensors and batteries. However, the presence of a tetragonal phase will seriously reduce the conductivity of Y-PSZ materials. As a sintering aid, Bi₂O₃ can be used to sinter materials with high oxygen ion conductivity at low temperatures. It is the first choice for the Y-PSZ doped system. A new microwave sintering technique prepared Bi₂O₃–Y-PSZ powders. The effects of doping amount of Bi₂O₃ on the microstructure, phase transition, and tetragonal phase content of Y-PSZ during sintering were researched. The results displayed that doping Bi₂O₃ improved the tetragonal phase content of the ZrO₂. The tetragonal phase content of the samples increased from 59.72% to 94.69% after sintering at 750 °C for 1 h. After doping Bi₂O₃, the aggregation of the samples reduced gradually, and the particles dispersed evenly. The average particle sizes of raw material and samples doped with different amounts of Bi₂O₃ were 0.0794 μm, 0.0638 μm, 0.0629 μm, 0.0794 μm, 0.1116 μm, respectively. Therefore, in the doping amount (1 mol%-4 mol%), the Bi₂O₃ doped Y-PSZ system with 2 mol% has the highest tetragonal phase content, the best dispersion, the smallest average particle size, and the most uniform particle distribution.
- Published
- 2023
38. Line-of-shower trigger method to lower energy threshold for GRB detection using LHAASO-WCDA
- Author
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C. F. Feng, Bin Zhou, X. L. Ji, R. Lu, H. B. Xiao, J. R. Shi, W. Zeng, Z. H. Wang, Shengxue Zhang, Pak-Hin Thomas Tam, H. C. Li, Jun Liu, H. Y. Jia, B. D'Ettorre Piazzoli, W. X. Wu, Junjie Mao, Y. Q. Guo, Dong Liu, F. Ji, H. R. Wu, Y. J. Wei, Alejandro Sáiz, Oleg Shchegolev, L. Feng, V. Rulev, L. Xue, Xuliang Chen, Xing-Yuan Hou, D. M. Wei, S. Hu, M. L. Chen, Jianeng Zhou, J. Y. Liu, Warit Mitthumsiri, Y. Zhang, Q. An, Y. He, Q. Gao, Ruizhi Yang, X. N. Sun, H. B. Hu, H. Liu, L. Chen, X. G. Wang, S. Q. Xi, J. Fang, X. H. You, Ping Zhou, Z. C. Huang, Y. Z. Li, P. F. Zhang, C. Y. Wu, Hong-Guang Wang, G. M. Xiang, W. Liu, Yu-Lei Chen, Zihuang Cao, X. C. Chang, Z. K. Zeng, Y. J. Bi, H. D. Liu, Y. D. Cheng, Bo Zhang, Y. Zheng, L. Q. Yin, Duo Yan, F. Zheng, Hao Zhou, X. X. Zhou, Q. Yuan, Hefan Li, J. F. Chang, Z. X. Liu, Felix Aharonian, H. N. He, C. D. Gao, Lei Zhao, Q. H. Chen, Youping Li, Y. M. Ye, B. B. Li, Yongchun Wang, Y. D. Cui, Bai Yibing, L. P. Wang, J. B. Zhao, Y. J. Wang, J. Y. Yang, S. Z. Chen, Yunchao Liu, B. Z. Dai, Rong Xu, Z. X. Fan, Z. Y. You, Z. G. Dai, X. F. Wu, He Zhang, S. H. Feng, S. B. Yang, J. J. Xia, W. Gao, S. L. He, Y. P. Wang, B. M. Chen, Fan Yang, A. Masood, Kun Fang, S.H. Chen, Yugang Zhang, H. Cai, Lang Shao, H. Wang, J.W. Xia, L. Z. Zhao, G. C. Xiao, X. X. Zhai, Y. C. Nan, Shi-Qi Hu, X. J. Bi, Z. Li, R. Liu, E. W. Liang, X. Zuo, M. J. Yang, Y. H. Yao, W. L. Li, L. X. Zhang, H. K. Lv, Xufang Li, B. Y. Pang, Zebo Tang, M. H. Gu, Z. Y. Pei, Xuejiao Li, F. R. Zhu, T. L. Chen, Qie Sun, K. J. Zhu, Ying Zhang, H. M. Zhang, J. Chen, H. L. Dai, Y. L. Xin, T. Wen, S. W. Cui, M. Zha, J. C. He, W. H. Huang, L. X. Bai, Binyu Zhao, Yun-Feng Liang, Jixia Li, X. H. Cui, Xinbo He, K. Jiang, X. J. Hu, J. W. Zhang, Li-Sheng Geng, Wenwu Tian, Z. X. Wang, Xiaofei Zhang, David Ruffolo, Yu. V. Stenkin, C. Hou, Z. B. Sun, Shuibin Lin, Lu Zhang, K. Levochkin, Cheng Guang Zhu, X. D. Sheng, Minghao Qi, Houdun Zeng, Jun-Jie Wei, Jia Zhang, Y. A. Han, H. B. Li, Danzengluobu, Rui Zhang, H. C. Song, Linbin Yang, Y. Z. Fan, J. T. Cai, H. H. He, Y. M. Xing, F. Y. Li, D. H. Huang, H. Zhu, Xiang Zhang, M. M. Ge, J. G. Guo, S. R. Zhang, N. Cheng, L. L. Ma, G. H. Gong, J. S. Wang, Cunguo Wang, Shujuan Liu, N. Yin, Y. H. Yu, W. J. Long, Axikegu, Xuelong Wang, P. P. Zhang, Chunlong Li, Minghui Liu, D. Bastieri, Jinyao Liu, Z. G. Yao, X. H. Ma, M. Heller, K. Li, Z. J. Jiang, J. Liu, R. N. Wang, V. I. Stepanov, Jian Wang, Chiming Jin, D.A. Kuleshov, G. G. Xin, M. J. Chen, S. P. Zhao, Y. Y. Guo, Donglian Xu, X. L. Guo, X. J. Dong, Y. K. Hor, T. Montaruli, Y. L. Feng, W. Wang, P. Pattarakijwanich, S. Wu, B. D. Wang, C. X. Liu, Y. W. Bao, X. T. Huang, R. Zhou, L. Y. Wang, D. della Volpe, C. W. Yang, Jun-Hui Fan, Zujian Wang, Q. B. Gou, Qizhi Huang, B. Liu, Bingshui Gao, Xiang-Yu Wang, Tao Zeng, and Bin Ma
- Subjects
Physics ,Nuclear and High Energy Physics ,Cherenkov detector ,Astrophysics::High Energy Astrophysical Phenomena ,Detector ,Astrophysics ,law.invention ,Air shower ,Nuclear Energy and Engineering ,Duty cycle ,law ,Observatory ,Gamma-ray burst ,Energy (signal processing) ,Line (formation) - Abstract
Observation of high energy and very high emission from Gamma Ray Bursts (GRBs) is crucial to study the gigantic explosion and the underline processes. With a large field-of-view and almost full duty cycle, the Water Cherenkov Detector Array (WCDA), a sub-array of the Large High Altitude Air Shower Observatory (LHAASO), is appropriate to monitor the very high energy emission from unpredictable transients such as GRBs. Nevertheless, the main issue for an extensive air shower array is the high energy threshold which limits the horizon of the detector. To address this issue a new trigger method is developed in this article to lower the energy threshold of WCDA for GRB observation. The proposed method significantly improves the detection efficiency of WCDA for gamma-rays around the GRB direction at 10-300 GeV. The sensitivity of the WCDA for GRB detection with the new trigger method is estimated. The achieved sensitivity of the quarter WCDA array above 10 GeV is comparable with that of Fermi-LAT. The data analysis process and corresponding fluence upper limit for GRB 190719C is presented as an example.
- Published
- 2021
39. [The research progress of multimodal imaging for the diagnosis of reticular pseudodrusen]
- Author
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Q G, Guo, X H, Guo, S Y, Li, and B, Lei
- Subjects
Humans ,Multimodal Imaging - Abstract
The emergence and development of multimodal imaging techniques, such as optical coherence tomography, fundus autofluorescence and adaptive optics, make it much easier to differentiate reticular pseudodrusen (RPD) from other fundus lesions. It is of great significance to understand the imaging characteristics of RPD observed with multimodal imaging techniques. This article reviews the formation mechanism and multimodal imaging characteristics of RPD, so as to provide help for better identification of RPD and assessment of the development and prognosis of the disease.随着眼底相干光层析成像术、自发荧光、自适应光学等影像技术的出现和发展,网状假性玻璃膜疣(RPD)的组织形态和分布特点也更明晰。熟知多模式影像中RPD的表现特征对于疾病的鉴别诊断具有重要意义。本文对RPD的形成机制及多模式影像表现的相关研究进行综述,以期为准确地识别RPD和评估疾病的进展预后提供帮助。.
- Published
- 2022
40. Glucose modulates transcription factor dimerization to enable tissue differentiation
- Author
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Vanessa Lopez-Pajares, Aparna Bhaduri, Yang Zhao, Gayatri Gowrishankar, Laura Donohue, Margaret G. Guo, Zurab Siprashvili, Weili Miao, Duy T. Nguyen, Albert M. Li, Ronald L. Shanderson, Robin M. Meyers, Angela Guerrero, Andrew L. Ji, Omar S. Garcia, Shiying Tao, Lindsey M. Meservey, Xue Yang, Sanjiv S. Gambhir, Jiangbin Ye, and Paul A. Khavari
- Abstract
Glucose is a universal energy currency for living organisms, however, its non-energetic functions in processes such as differentiation are undefined. In epidermis, differentiating cells exhibit dynamic changes in gene expression1–4driven by specific transcription factors (TFs)5–9. The interplay between such TFs and biomolecules that also change in this process is not understood. Metabolomic analyses revealed that increased intracellular glucose accompanies differentiation of epidermal keratinocytes. This elevation also occurred in differentiating cells from other tissues and was verified in epidermal tissue engineered with glucose sensors, which detected a glucose gradient that peaked in the outermost differentiated layers. Free glucose accumulation, unaccompanied by its increased metabolism, was essential for epidermal differentiation and required GLUT1, GLUT3, and SGLT1 transporters. Glucose affinity chromatography and azido-glucose click chemistry uncovered glucose binding to diverse regulatory proteins, including the IRF6 TF, whose epidermal knockout confirmed its requirement in glucose-dependent differentiation. Direct glucose binding enabled IRF6 dimerization, DNA binding, genomic localization, and induction of IRF6 target genes, including essential pro-differentiation TFsGRHL1, GRHL3, HOPXandPRDM1. The IRF6R84Cmutant found in undifferentiated cancers was unable to bind glucose. These data identify a new role for glucose as a gradient morphogen that modulates protein multimerization in cellular differentiation.
- Published
- 2022
41. A dynamic range extension system for LHAASO WCDA-1
- Author
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F. Aharonian, Q. An, null Axikegu, L. X. Bai, Y. X. Bai, Y. W. Bao, D. Bastieri, X. J. Bi, Y. J. Bi, H. Cai, J. T. Cai, Z. Cao, J. Chang, J. F. Chang, X. C. Chang, B. M. Chen, J. Chen, L. Chen, M. J. Chen, M. L. Chen, Q. H. Chen, S. H. Chen, S. Z. Chen, T. L. Chen, X. L. Chen, Y. Chen, N. Cheng, Y. D. Cheng, S. W. Cui, X. H. Cui, Y. D. Cui, B. Z. Dai, H. L. Dai, Z. G. Dai, null Danzengluobu, D. della Volpe, B. D’Ettorre Piazzoli, X. J. Dong, J. H. Fan, Y. Z. Fan, Z. X. Fan, J. Fang, K. Fang, C. F. Feng, L. Feng, S. H. Feng, Y. L. Feng, B. Gao, C. D. Gao, Q. Gao, W. Gao, M. M. Ge, L. S. Geng, G. H. Gong, Q. B. Gou, M. H. Gu, J. G. Guo, X. L. Guo, Y. Q. Guo, Y. Y. Guo, Y. A. Han, H. H. He, H. N. He, J. C. He, S. L. He, X. B. He, Y. He, M. Heller, Y. K. Hor, C. Hou, X. Hou, H. B. Hu, S. Hu, S. C. Hu, X. J. Hu, D. H. Huang, Q. L. Huang, W. H. Huang, X. T. Huang, Y. Huang, Z. C. Huang, F. Ji, X. L. Ji, H. Y. Jia, K. Jiang, Z. J. Jiang, C. Jin, D. Kuleshov, K. Levochkin, B. B. Li, C. Li, F. Li, H. B. Li, H. C. Li, H. Y. Li, J. Li, K. Li, W. L. Li, X. Li, X. R. Li, Y. Li, Y. Z. Li, Z. Li, E. W. Liang, Y. F. Liang, S. J. Lin, B. Liu, C. Liu, D. Liu, H. Liu, H. D. Liu, J. Liu, J. L. Liu, J. S. Liu, J. Y. Liu, M. Y. Liu, R. Y. Liu, S. M. Liu, W. Liu, Y. N. Liu, Z. X. Liu, W. J. Long, R. Lu, H. K. Lv, B. Q. Ma, L. L. Ma, X. H. Ma, J. R. Mao, A. Masood, W. Mitthumsiri, T. Montaruli, Y. C. Nan, B. Y. Pang, P. Pattarakijwanich, Z. Y. Pei, M. Y. Qi, D. Ruffolo, V. Rulev, A. Sáiz, L. Shao, O. Shchegolev, X. D. Sheng, J. R. Shi, H. C. Song, Yu. V. Stenkin, V. Stepanov, Q. N. Sun, X. N. Sun, Z. B. Sun, P. H. T. Tam, Z. B. Tang, W. W. Tian, B. D. Wang, C. Wang, H. Wang, H. G. Wang, J. C. Wang, J. S. Wang, L. P. Wang, L. Y. Wang, R. N. Wang, W. Wang, X. G. Wang, X. J. Wang, X. Y. Wang, Y. D. Wang, Y. J. Wang, Y. P. Wang, Z. Wang, Z. H. Wang, Z. X. Wang, D. M. Wei, J. J. Wei, Y. J. Wei, T. Wen, C. Y. Wu, H. R. Wu, S. Wu, W. X. Wu, X. F. Wu, S. Q. Xi, J. Xia, J. J. Xia, G. M. Xiang, G. Xiao, H. B. Xiao, G. G. Xin, Y. L. Xin, Y. Xing, D. L. Xu, R. X. Xu, L. Xue, D. H. Yan, C. W. Yang, F. F. Yang, J. Y. Yang, L. L. Yang, M. J. Yang, R. Z. Yang, S. B. Yang, Y. H. Yao, Z. G. Yao, Y. M. Ye, L. Q. Yin, N. Yin, X. H. You, Z. Y. You, Y. H. Yu, Q. Yuan, H. D. Zeng, T. X. Zeng, W. Zeng, Z. K. Zeng, M. Zha, X. X. Zhai, B. B. Zhang, H. M. Zhang, H. Y. Zhang, J. L. Zhang, J. W. Zhang, L. Zhang, L. X. Zhang, P. F. Zhang, P. P. Zhang, R. Zhang, S. R. Zhang, S. S. Zhang, X. Zhang, X. P. Zhang, Y. Zhang, Y. F. Zhang, Y. L. Zhang, B. Zhao, J. Zhao, L. Zhao, L. Z. Zhao, S. P. Zhao, F. Zheng, Y. Zheng, B. Zhou, H. Zhou, J. N. Zhou, P. Zhou, R. Zhou, X. X. Zhou, C. G. Zhu, F. R. Zhu, H. Zhu, K. J. Zhu, and X. Zuo
- Subjects
Physics ,Nuclear and High Energy Physics ,Physics::Instrumentation and Detectors ,Dynamic range ,Astrophysics::High Energy Astrophysical Phenomena ,Astrophysics::Instrumentation and Methods for Astrophysics ,Cosmic ray ,Extension (predicate logic) ,Measure (mathematics) ,Effective nuclear charge ,Nuclear physics ,Air shower ,Nuclear Energy and Engineering ,Orders of magnitude (time) ,Energy (signal processing) - Abstract
The main scientific goal of LHAASO-WCDA is to survey gamma-ray sources with energy from 100 GeV to 30 TeV. To observe high-energy shower events, especially to measure the energy spectrum of cosmic rays from 100 TeV to 10 PeV, a dynamic range extension system (WCDA++) is designed to use a 1.5-inch PMT with a dynamic range of four orders of magnitude for each cell in WCDA-1. The dynamic range is extended by using these PMTs to measure the effective charge density in the core region of air shower events, which is an important parameter for identifying the composition of primary particles. The system has been running for more than one year. In this paper, the details of the design and performance of WCDA++ are presented.
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- 2021
42. BLZ945 derivatives for PET imaging of colony stimulating factor-1 receptors in the brain
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Frederick T. Chin, Zheng Miao, Albert D. Windhorst, Scarlett G. Guo, Samantha T. Reyes, Berend van der Wildt, Bin Shen, Jessica L. Klockow, Alex Romero, Ning Zhao, Jun H. Park, Radiology and nuclear medicine, and Amsterdam Neuroscience - Brain Imaging
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Macrophage colony-stimulating factor ,Cancer Research ,Biodistribution ,Chemistry ,Receptor expression ,Pharmacology ,030218 nuclear medicine & medical imaging ,Colony stimulating factor 1 receptor ,03 medical and health sciences ,0302 clinical medicine ,In vivo ,030220 oncology & carcinogenesis ,Blood plasma ,Molecular Medicine ,Radiology, Nuclear Medicine and imaging ,Benzothiazoles ,Picolinic Acids ,Receptor ,Ex vivo - Abstract
Background The kinase colony stimulating factor-1 receptor (CSF-1R) has recently been identified as a novel therapeutic target for decreasing tumor associated macrophages and microglia load in cancer treatment. In glioblastoma multiforme (GBM), a high-grade cancer in the brain with extremely poor prognosis, macrophages and microglia can make up to 50% of the total tumor mass. Currently, no non-invasive methods are available for measuring CSF-1R expression in vivo. The aim of this work is to develop a PET tracer for imaging of CSF-1R receptor expression in the brain for future GBM patient selection and treatment monitoring. Methods BLZ945 and a derivative that potentially allows for fluorine-18 labeling were synthesized and evaluated in vitro to determine their affinity towards CSF-1R. BLZ945 was radiolabeled with carbon-11 by N-methylation of des-methyl-BLZ945 using [11C]CH3I. Following administration to healthy mice, metabolic stability of [11C]BLZ945 in blood and brain and activity distribution were determined ex vivo. PET scanning was performed at baseline, efflux transporter blocking, and CSF-1R blocking conditions. Finally, [11C]BLZ945 binding was evaluated in vitro by autoradiography on mouse brain sections. Results BLZ945 was the most potent compound in our series with an IC50 value of 6.9 ± 1.4 nM. BLZ945 was radiolabeled with carbon-11 in 20.7 ± 1.1% decay corrected radiochemical yield in a 60 min synthesis procedure with a radiochemical purity of >95% and a molar activity of 153 ± 34 GBq·μmol−1. Ex vivo biodistribution showed moderate brain uptake and slow wash-out, in addition to slow blood clearance. The stability of BLZ945 in blood plasma and brain was >99% at 60 min post injection. PET scanning demonstrated BLZ945 to be a substrate for efflux transporters. High brain uptake was observed, which was shown to be mostly non-specific. In accordance, in vitro autoradiography on brain sections revealed high non-specific binding. Conclusions [11C]BLZ945, a CSF-1R PET tracer, was synthesized in high yield and purity. The tracer has high potency for the target, however, future studies are warranted to address non-specific binding and tracer efflux before BLZ945 or derivatives could be translated into humans for brain imaging.
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- 2021
43. Constraints on heavy decaying dark matter from 570 days of LHAASO observations
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Zhen, Cao, F, Aharonian, Q, An, Axikegu, L X, Bai, Y X, Bai, Y W, Bao, D, Bastieri, X J, Bi, Y J, Bi, J T, Cai, Zhe, Cao, J, Chang, J F, Chang, E S, Chen, Liang, Chen, Long, Chen, M J, Chen, M L, Chen, Q H, Chen, S H, Chen, S Z, Chen, T L, Chen, Y, Chen, H L, Cheng, N, Cheng, Y D, Cheng, S W, Cui, X H, Cui, Y D, Cui, B, D'Ettorre Piazzoli, B Z, Dai, H L, Dai, Z G, Dai, Danzengluobu, D, Della Volpe, K K, Duan, J H, Fan, Y Z, Fan, Z X, Fan, J, Fang, K, Fang, C F, Feng, L, Feng, S H, Feng, X T, Feng, Y L, Feng, B, Gao, C D, Gao, L Q, Gao, Q, Gao, W, Gao, W K, Gao, M M, Ge, L S, Geng, G H, Gong, Q B, Gou, M H, Gu, F L, Guo, J G, Guo, X L, Guo, Y Q, Guo, Y Y, Guo, Y A, Han, H H, He, H N, He, S L, He, X B, He, Y, He, M, Heller, Y K, Hor, C, Hou, X, Hou, H B, Hu, Q, Hu, S, Hu, S C, Hu, X J, Hu, D H, Huang, W H, Huang, X T, Huang, X Y, Huang, Y, Huang, Z C, Huang, X L, Ji, H Y, Jia, K, Jia, K, Jiang, Z J, Jiang, M, Jin, M M, Kang, T, Ke, D, Kuleshov, K, Levochkin, B B, Li, Cheng, Li, Cong, Li, F, Li, H B, Li, H C, Li, H Y, Li, J, Li, Jian, Li, Jie, Li, K, Li, W L, Li, X R, Li, Xin, Li, Y Z, Li, Zhe, Li, Zhuo, Li, E W, Liang, Y F, Liang, S J, Lin, B, Liu, C, Liu, D, Liu, H, Liu, H D, Liu, J, Liu, J L, Liu, J S, Liu, J Y, Liu, M Y, Liu, R Y, Liu, S M, Liu, W, Liu, Y, Liu, Y N, Liu, W J, Long, R, Lu, Q, Luo, H K, Lv, B Q, Ma, L L, Ma, X H, Ma, J R, Mao, A, Masood, Z, Min, W, Mitthumsiri, Y C, Nan, Z W, Ou, B Y, Pang, P, Pattarakijwanich, Z Y, Pei, M Y, Qi, Y Q, Qi, B Q, Qiao, J J, Qin, D, Ruffolo, A, Sáiz, C Y, Shao, L, Shao, O, Shchegolev, X D, Sheng, J Y, Shi, H C, Song, Yu V, Stenkin, V, Stepanov, Y, Su, Q N, Sun, X N, Sun, Z B, Sun, P H T, Tam, Z B, Tang, W W, Tian, B D, Wang, C, Wang, H, Wang, H G, Wang, J C, Wang, J S, Wang, L P, Wang, L Y, Wang, R, Wang, R N, Wang, W, Wang, X G, Wang, X Y, Wang, Y, Wang, Y D, Wang, Y J, Wang, Y P, Wang, Z H, Wang, Z X, Wang, Zhen, Wang, Zheng, Wang, D M, Wei, J J, Wei, Y J, Wei, T, Wen, C Y, Wu, H R, Wu, S, Wu, X F, Wu, Y S, Wu, S Q, Xi, J, Xia, J J, Xia, G M, Xiang, D X, Xiao, G, Xiao, G G, Xin, Y L, Xin, Y, Xing, Z, Xiong, D L, Xu, R X, Xu, L, Xue, D H, Yan, J Z, Yan, C W, Yang, F F, Yang, H W, Yang, J Y, Yang, L L, Yang, M J, Yang, R Z, Yang, S B, Yang, Y H, Yao, Z G, Yao, Y M, Ye, L Q, Yin, N, Yin, X H, You, Z Y, You, Y H, Yu, Q, Yuan, H, Yue, H D, Zeng, T X, Zeng, W, Zeng, Z K, Zeng, M, Zha, X X, Zhai, B B, Zhang, F, Zhang, H M, Zhang, H Y, Zhang, J L, Zhang, L X, Zhang, Li, Zhang, Lu, Zhang, P F, Zhang, P P, Zhang, R, Zhang, S B, Zhang, S R, Zhang, S S, Zhang, X, Zhang, X P, Zhang, Y F, Zhang, Y L, Zhang, Yi, Zhang, Yong, Zhang, B, Zhao, J, Zhao, L, Zhao, L Z, Zhao, S P, Zhao, F, Zheng, Y, Zheng, B, Zhou, H, Zhou, J N, Zhou, P, Zhou, R, Zhou, X X, Zhou, C G, Zhu, F R, Zhu, H, Zhu, K J, Zhu, X, Zuo, S, Ando, M, Chianese, D F G, Fiorillo, G, Miele, K C Y, Ng, and GRAPPA (ITFA, IoP, FNWI)
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High Energy Astrophysical Phenomena (astro-ph.HE) ,High Energy Physics - Phenomenology ,Cosmology and Nongalactic Astrophysics (astro-ph.CO) ,High Energy Physics - Phenomenology (hep-ph) ,General Physics and Astronomy ,FOS: Physical sciences ,Astrophysics - High Energy Astrophysical Phenomena ,Astrophysics - Cosmology and Nongalactic Astrophysics - Abstract
The kilometer square array (KM2A) of the large high altitude air shower observatory (LHAASO) aims at surveying the northern γ-ray sky at energies above 10 TeV with unprecedented sensitivity. γ-ray observations have long been one of the most powerful tools for dark matter searches, as, e.g., high-energy γ rays could be produced by the decays of heavy dark matter particles. In this Letter, we present the first dark matter analysis with LHAASO-KM2A, using the first 340 days of data from 1/2-KM2A and 230 days of data from 3/4-KM2A. Several regions of interest are used to search for a signal and account for the residual cosmic-ray background after γ/hadron separation. We find no excess of dark matter signals, and thus place some of the strongest γ-ray constraints on the lifetime of heavy dark matter particles with mass between 105 and 109 GeV. Our results with LHAASO are robust, and have important implications for dark matter interpretations of the diffuse astrophysical high-energy neutrino emission.
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- 2022
44. Treatment with activin type ii receptor antibody improves cardiac function in mice after myocardial infarction
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W B Bao, N H Haskins, C G Gonzalez, K R Ryden-Markinhutha, B G Gill, L G Guo, K J Jennbacken, Q W Wang, and S H Hagvall
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Cardiology and Cardiovascular Medicine - Abstract
Background Activin type ii receptor (ActRII) binding to its natural ligands including myostatin, activin, and growth development factor 11 negatively regulates muscle growth. Blockade of the ligands/ActRII signaling with human ActRII monoclonal antibody has been shown to increase body lean mass and reduce fat mass in patients with type 2 diabetes. However, the blockade effect on the ligands/ActRII signaling in heart failure with or without cardiac cachexia remains controversial. We hypothesized that the blockade effect on the ligands/ActRII signaling with a murine ActRII monoclonal antibody would improve cardiac function in a mouse model of heart failure. Methods Under anesthesia with isoflurane in oxygen, C57BL/6 mice were subjected to sham surgery or myocardial infarction (MI) by ligation of left anterior descending coronary artery to induce heart failure. Mice were randomized into treatment groups based on ejection fraction measured by Vevo 3100 Imaging System two weeks after MI. MI mice were treated weekly with vehicle (n=11), 10 mg/kg (n=12), or 20 mg/kg (n=12) ActRII antibody by subcutaneous injection for 8 weeks. Cardiac function was determined by Vevo 3100 Imaging system at 4, 8 weeks post-treatment, respectively. Body lean and fat mass were determined by Bruker's Whole Body Composition Analyzer. Myocardial infarct size was determined by Masson's trichrome staining on heart sections. Results Myocardial infarction markedly impaired cardiac function in mice. Ejection fraction reduced to 21.3±1.9% in MI mice compared to 56.3±1.2% in sham-operated mice (p Conclusion ActRII antibody dose-dependently improved cardiac function independent of myocardial infarct size post-MI. Although antibody significantly increased body weight and lean mass, it did not significantly increase heart weight, indicating that antibody treatment did not cause adverse remodeling post-MI while it remarkably improved cardiac function. Our data suggest that ActRII antibody could be a novel treatment for heart failure with reduced ejection fraction and may be particularly beneficial in patients with cachexia. Funding Acknowledgement Type of funding sources: None.
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- 2022
45. Seasonal Air–Sea Exchange Dynamics of Polychlorinated Biphenyls Over the East China Marginal Seas: The Role of Water Masses in a Complex Coastal–Ocean Current System
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H. M. Yu, T. Lin, T. F. Guo, X. Sun, Y. B. Cao, L. Duan, X. S. Sun, and Z. G. Guo
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Atmospheric Science ,Geophysics ,Space and Planetary Science ,Earth and Planetary Sciences (miscellaneous) - Published
- 2022
46. Fast history matching and optimization using a novel physics-based data-driven model: An application to a diatomite reservoir with hundreds of wells
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X. Guan, Z. Wang, F. Kostakis, G. Ren, G. Guo, W.J. Milliken, B. Rangaratnam, and X.-H. Wen
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- 2023
47. Characterization and Fabrication of Novel Micromachined Electrode for BSN-Based Vital Signs Monitoring System.
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Ding G. Guo, Francis Eng Hock Tay, Lin Xu, L. M. Yu, Myo Naing Nyan, F. W. Chong, K. L. Yap, and B. Xu
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- 2009
- Full Text
- View/download PDF
48. Random Variates Generating Methods of Time-between-failures for the Repairable Systems under Age-reduction Preventive Maintenance.
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Chun-Yuan Cheng, Renkuan G. Guo, and Mei-Ling Liu
- Published
- 2009
49. Expected Tail Loss Efficient Frontiers for CDOS of Bespoke Portfolios Under One-Factor Copula Marginal Distributions.
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Diresh Jewan, Renkuan G. Guo, and Gareth Witten
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- 2008
- Full Text
- View/download PDF
50. A Long-term Wearable Vital Signs Monitoring System using BSN.
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Ding G. Guo, Francis Eng Hock Tay, Lin Xu, L. M. Yu, Myo Naing Nyan, F. W. Chong, K. L. Yap, and B. Xu
- Published
- 2008
- Full Text
- View/download PDF
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