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1. Behavior of KCl sorbent traps and KCl trapping solutions used for atmospheric mercury speciation: stability and specificity

Author: J. Gačnik, I. Živković, S. Ribeiro Guevara, R. Jaćimović, J. Kotnik, G. De Feo, M. A. Dexter, W. T. Corns, and M. Horvat
Subjects: Environmental engineering, TA170-171, Earthwork. Foundations, TA715-787
Abstract: Atmospheric mercury speciation is of paramount importance for understanding the behavior of mercury once it is emitted into the atmosphere as gaseous elemental mercury (GEM), gaseous oxidized mercury (GOM) and particulate-bound mercury (PBM). GOM and PBM can also be formed in the atmosphere; their sampling is the most problematic step in the atmospheric mercury speciation. GOM sampling with speciation traps composed of KCl sorbent materials and KCl trapping solutions are commonly used sampling methods, although the research conducted with them at ambient air concentrations is limited. The results of the specificity test demonstrated that the KCl sorbent traps are highly specific when using new traps, while their specificity drops dramatically when they are reused. The results of the stability test indicated that the highest Hg2+ losses (up to 5.5 % of Hg2+ loss) occur when low amounts of Hg2+ (< 1 ng) are loaded, due to a reduction of Hg2+ to Hg0. KCl trapping solutions have also been considered as a selective trapping media for GOM in atmospheric samples. A dimensionless Henry law constant was experimentally derived and was used to calculate the solubility of elemental Hg in KCl solution. The degree of GEM oxidation was established by purging elemental Hg calibration gas into a KCl solution and determining the GOM trapped using aqueous-phase propylation liquid–liquid extraction and gas chromatography–atomic fluorescence spectrometry (GC-AFS) measurement. A positive GOM bias was observed due to the solubility and oxidation of GEM in KCl trapping solutions, strongly suggesting that this approach is unsuitable for atmospheric mercury speciation measurements.
Published: 2021
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2. Guidance to 2018 good practice: ARIA digitally-enabled, integrated, person-centred care for rhinitis and asthma

Author: J. Bousquet, A. Bedbrook, W. Czarlewski, G. L. Onorato, S. Arnavielhe, D. Laune, E. Mathieu-Dupas, J. Fonseca, E. Costa, O. Lourenço, M. Morais-Almeida, A. Todo-Bom, M. Illario, E. Menditto, G. W. Canonica, L. Cecchi, R. Monti, L. Napoli, M. T. Ventura, G. De Feo, W. J. Fokkens, N. H. Chavannes, S. Reitsma, A. A. Cruz, J. da Silva, F. S. Serpa, D. Larenas-Linnemann, J. M. Fuentes Perez, Y. R. Huerta-Villalobos, D. Rivero-Yeverino, E. Rodriguez-Zagal, A. Valiulis, R. Dubakiene, R. Emuzyte, V. Kvedariene, I. Annesi-Maesano, H. Blain, P. Bonniaud, I. Bosse, Y. Dauvilliers, P. Devillier, J. F. Fontaine, J. L. Pépin, N. Pham-Thi, F. Portejoie, R. Picard, N. Roche, C. Rolland, P. Schmidt-Grendelmeier, P. Kuna, B. Samolinski, J. M. Anto, V. Cardona, J. Mullol, H. Pinnock, D. Ryan, A. Sheikh, S. Walker, S. Williams, S. Becker, L. Klimek, O. Pfaar, K. C. Bergmann, R. Mösges, T. Zuberbier, R. E. Roller-Wirnsberger, P. V. Tomazic, T. Haahtela, J. Salimäki, S. Toppila-Salmi, E. Valovirta, T. Vasankari, B. Gemicioğlu, A. Yorgancioglu, N. G. Papadopoulos, E. P. Prokopakis, I. G. Tsiligianni, S. Bosnic-Anticevich, R. O’Hehir, J. C. Ivancevich, H. Neffen, M. E. Zernotti, I. Kull, E. Melén, M. Wickman, C. Bachert, P. W. Hellings, G. Brusselle, S. Palkonen, C. Bindslev-Jensen, E. Eller, S. Waserman, L. P. Boulet, J. Bouchard, D. K. Chu, H. J. Schünemann, M. Sova, G. De Vries, M. van Eerd, I. Agache, I. J. Ansotegui, M. Bewick, T. Casale, M. Dykewick, M. Ebisawa, R. Murray, R. Naclerio, Y. Okamoto, D. V. Wallace, and The MASK study group
Subjects: App, Asthma, Care pathways, MASK, mHealth, Rhinitis, Immunologic diseases. Allergy, RC581-607
Abstract: Abstract Aims Mobile Airways Sentinel NetworK (MASK) belongs to the Fondation Partenariale MACVIA-LR of Montpellier, France and aims to provide an active and healthy life to rhinitis sufferers and to those with asthma multimorbidity across the life cycle, whatever their gender or socio-economic status, in order to reduce health and social inequities incurred by the disease and to improve the digital transformation of health and care. The ultimate goal is to change the management strategy in chronic diseases. Methods MASK implements ICT technologies for individualized and predictive medicine to develop novel care pathways by a multi-disciplinary group centred around the patients. Stakeholders Include patients, health care professionals (pharmacists and physicians), authorities, patient’s associations, private and public sectors. Results MASK is deployed in 23 countries and 17 languages. 26,000 users have registered. EU grants (2018) MASK is participating in EU projects (POLLAR: impact of air POLLution in Asthma and Rhinitis, EIT Health, DigitalHealthEurope, Euriphi and Vigour). Lessons learnt (i) Adherence to treatment is the major problem of allergic disease, (ii) Self-management strategies should be considerably expanded (behavioural), (iii) Change management is essential in allergic diseases, (iv) Education strategies should be reconsidered using a patient-centred approach and (v) Lessons learnt for allergic diseases can be expanded to chronic diseases.
Published: 2019
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3. MASK 2017: ARIA digitally-enabled, integrated, person-centred care for rhinitis and asthma multimorbidity using real-world-evidence

Author: J. Bousquet, S. Arnavielhe, A. Bedbrook, M. Bewick, D. Laune, E. Mathieu-Dupas, R. Murray, G. L. Onorato, J. L. Pépin, R. Picard, F. Portejoie, E. Costa, J. Fonseca, O. Lourenço, M. Morais-Almeida, A. Todo-Bom, A. A. Cruz, J. da Silva, F. S. Serpa, M. Illario, E. Menditto, L. Cecchi, R. Monti, L. Napoli, M. T. Ventura, G. De Feo, D. Larenas-Linnemann, M. Fuentes Perez, Y. R. Huerta Villabolos, D. Rivero-Yeverino, E. Rodriguez-Zagal, F. Amat, I. Annesi-Maesano, I. Bosse, P. Demoly, P. Devillier, J. F. Fontaine, J. Just, T. P. Kuna, B. Samolinski, A. Valiulis, R. Emuzyte, V. Kvedariene, D. Ryan, A. Sheikh, P. Schmidt-Grendelmeier, L. Klimek, O. Pfaar, K. C. Bergmann, R. Mösges, T. Zuberbier, R. E. Roller-Wirnsberger, P. Tomazic, W. J. Fokkens, N. H. Chavannes, S. Reitsma, J. M. Anto, V. Cardona, T. Dedeu, J. Mullol, T. Haahtela, J. Salimäki, S. Toppila-Salmi, E. Valovirta, B. Gemicioğlu, A. Yorgancioglu, N. Papadopoulos, E. P. Prokopakis, S. Bosnic-Anticevich, R. O’Hehir, J. C. Ivancevich, H. Neffen, E. Zernotti, I. Kull, E. Melen, M. Wickman, C. Bachert, P. Hellings, S. Palkonen, C. Bindslev-Jensen, E. Eller, S. Waserman, M. Sova, G. De Vries, M. van Eerd, I. Agache, T. Casale, M. Dykewickz, R. N. Naclerio, Y. Okamoto, D. V. Wallace, and MASK study group
Subjects: App, ARIA, Asthma, Care pathways, MASK, mHealth, Immunologic diseases. Allergy, RC581-607
Abstract: Abstract mHealth, such as apps running on consumer smart devices is becoming increasingly popular and has the potential to profoundly affect healthcare and health outcomes. However, it may be disruptive and results achieved are not always reaching the goals. Allergic Rhinitis and its Impact on Asthma (ARIA) has evolved from a guideline using the best evidence-based approach to care pathways suited to real-life using mobile technology in allergic rhinitis (AR) and asthma multimorbidity. Patients largely use over-the-counter medications dispensed in pharmacies. Shared decision making centered around the patient and based on self-management should be the norm. Mobile Airways Sentinel networK (MASK), the Phase 3 ARIA initiative, is based on the freely available MASK app (the Allergy Diary, Android and iOS platforms). MASK is available in 16 languages and deployed in 23 countries. The present paper provides an overview of the methods used in MASK and the key results obtained to date. These include a novel phenotypic characterization of the patients, confirmation of the impact of allergic rhinitis on work productivity and treatment patterns in real life. Most patients appear to self-medicate, are often non-adherent and do not follow guidelines. Moreover, the Allergy Diary is able to distinguish between AR medications. The potential usefulness of MASK will be further explored by POLLAR (Impact of Air Pollution on Asthma and Rhinitis), a new Horizon 2020 project using the Allergy Diary.
Published: 2018
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4. O-226 The microscopic se men improvement after surgical varicocele repair

Author: Rossana Colla, Alessia Nicoli, Daniele Santi, Daria Morini, Lorenzo Aguzzoli, Barbara Valli, Manuela Simoni, Jessica Daolio, Maria Teresa Villani, Beatrice Melli, Giorgia Spaggiari, D Viola, and G De Feo
Subjects: medicine.medical_specialty, Reproductive Medicine, business.industry, Rehabilitation, Urology, medicine, Obstetrics and Gynecology, business, Varicocele repair
Abstract: Study question Evaluation of the effect of varicocele correction on conventional and microscopic seminal parameters and evaluation of which factors might predict sperm improvement after surgical treatment. Summary answer The detailed morphologic sperm evaluation has been identified as a novel parameter expressing the post-surgical semen amelioration after varicocelectomy. What is known already Generally, varicocele develops during puberty and occurs more often on the left side for anatomic reasons. However, its diagnosis is commonly delayed, especially in asymptomatic cases, until the man consults an andrologist for couple infertility. A causative relationship between varicocele and impairment of semen quality has been largely investigated in the context of male infertility. Despite the florid literature available on this topic, the clinical benefit in terms of semen quality improvement after varicocele surgical repair remains controversial. Study design, size, duration An observational, retrospective clinical trial was carried out including patients undergoing surgical treatment for varicocele at the Day Surgery of the Urology Operative Unit of the Santa Maria Nuova Hospital-IRCCS of Reggio Emilia from September 2011 to March 2020. Primary outcome was the detailed morphologic microscopic sperm evaluation. Secondary outcomes were conventional semen analyses. Each patient was considered two times (before and after the surgery) and evaluated by both physical examination and ultrasonography. Participants/materials, setting, methods The inclusion criteria considered the patients with diagnosis of varicocele at ultrasound examination, attending surgical resolution and with at semen analyses before and after the surgery, were excluded patients with diagnosis of varicocele without surgical indication, and/or semen analyses performed only before or only after the surgery. In the statistical analysis a logistic multivariate regression analysis was performed in order to evaluate the change before and after surgery. Main results and the role of chance The post-surgical semen analysis was performed after a mean of 183.7 + 112.5 days since the surgery for a total of 121 males (mean age 24.6 + 4.1 years) enrolled. The surgical treatment leads to a significant increase in sperm concentration (p = 0.015) and percentage of progressive and total motility (p = 0.022 and p = 0.039, respectively), with a significant decrease in the percentage of immobile sperms (p = 0.013). In particular, semen concentration improved in 71.7% of patients (p = 0.010). Considering the detailed morphologic microscopic evaluation, a significant improvement was detected: head abnormalities showed a significant reduction, considering microcephaly (3.3 + 3.6 versus 2.2 + 2.9%, p = 0.015), macrocephaly (1.4 + 0.6 versus 1.2 + 0.9%, p = 0.043) and cytoplasmic appendix (1.4 + 0.8 versus 0.9 + 1.2%, p = 0.041). Moreover, surgery led to a significant reduction of tails abnormalities, considering absence (0.6 +2.3 versus 0.1 + 0.7, p = 0.048) and coiled tail (5.2 + 1.5 versus 6.6 + 2.0, p = 0.037). Thus, surgical varicocele resolution leads to a significant improvement in specific morphological semen parameters. The multivariate logistic analysis identified the ultrasound varicocele degree before surgery as a main predictor of the sperm concentration improvement (p = 0.016). The semen parameters improvement was higher for varicocele of I and II degree (p = 0.008). Limitations, reasons for caution The retrospective study design precluded from carrying out a case-control study to compare the surgical techniques. Moreover, the study design limited the availability of patients’ clinical data in order to performed a more comprehensive predictive analysis. Wider implications of the findings Using a complex statistical approach, it emerged that the greatest improvement in semen quality was obtained in case of mild varicocele, increasing the knowledge on the therapeutic potential of surgery. This result has clinical implications, since it could help to select those patients ‘to treat or not to treat’. Trial registration number none
Published: 2021
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5. Improving the efficacy of municipal solid waste collection with a communicative approach based on easily understandable indicators

Author: G. De Feo, Carmen Ferrara, P. Parente, and V. Iannone
Subjects: Environmental communicationGreenopoliLife cycle thinkingMSWPaper and cardboardSouthern Italy, Environmental Engineering, Municipal solid waste, 010504 meteorology & atmospheric sciences, Environmental communication, Carbon dioxide equivalent, cardboard, Mindset, 010501 environmental sciences, Environmental economics, Discount points, 01 natural sciences, Pollution, Variety (cybernetics), visual_art, Per capita, visual_art.visual_art_medium, Environmental Chemistry, Business, Waste Management and Disposal, 0105 earth and related environmental sciences
Abstract: The main aim of the study was to propose a useful methodological approach to define easily understandable indicators to use in communication campaigns organized to improve the efficacy of municipal solid waste collection. For this purpose, six economic-environmental indicators were defined, combining life cycle thinking and environmental communication. The indicators make it possible to obtain several combinations that can follow a variety of communication channels. Three indicators (quantity of recyclable materials recoverable from unsorted residual waste; total potential economic saving; number of jobs for young people as communicators) are expressed in absolute value and therefore refer to the whole community even if they are also good for single-targeted messages. The other three indicators (potential economic saving for each citizen; per capita saving of carbon dioxide equivalent; per capita saving of Disability Adjusted Life Years) are normalized with respect to the number of inhabitants and therefore refer to the individual citizen, but can also be used for global messages. As a case example, the methodology was applied to the collection of paper and cardboard in twelve Southern Italy cities obtaining very promising results. For example, the maximum quantity of paper and cardboard recoverable from unsorted waste would allow Naples and Palermo to recover more than €15 million. The maximum potential economic saving for each citizen was 25 €/capita. The economic saving obtained for Naples and Palermo could be translated in more than one thousand positions as young environmental communicators. Catania was the city with both the highest per capita potential saving of carbon dioxide (>60 kg CO2eq./capita) and maximum hypothetical per capita ‘life-time recovery’ (almost an hour). The innovative communication method used (‘Greenopoli’) assumed that school is the starting point to obtain a change of mindset because speaking with students (all potential communicators) means indirectly communicating with all other targets.
Published: 2019
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6. Treatment of allergic rhinitis during and outside the pollen season using mobile technology. a MASK study

Author: Sietze Reitsma, Josep M. Antó, Dermot Ryan, C. Stellato, W. Czarlewski, S. Shamai, G. De Vries, Elísio Costa, E. Melen, Esben Eller, Tari Haahtela, Carsten Bindslev-Jensen, Dana Wallace, Ricardo Pio Monti, P. V. Tomazic, A. Yorgancioglu, Oliver Pfaar, Michel Thibaudon, B. Samolinski, Asiyah Sheikh, Daniel Laune, J. C. Ivancevich, M. Morais-Almeida, Niels H. Chavannes, Ralph Mösges, Lorenzo Cecchi, Susan Waserman, Regina Roller-Wirnsberger, V. Cardona, Piotr Kuna, P. Devillier, M. van Eerd, Mikhail Sofiev, Rute Almeida, I. Kull, Isabelle Bosse, J Mullol, A Valero, Ioana Agache, João Fonseca, Violeta Kvedariene, J. F. Fontaine, A. Bedbrook, Sylvie Arnavielhe, Fotis Psarros, Jean Bousquet, Peter Schmid-Grendelmeier, A. A. Cruz, Ludger Klimek, Ruta Dubakiene, Nhân Pham-Thi, Judith Garcia-Aymerich, Benoit Pugin, G. De Feo, Thomas B. Casale, Ruth Murray, Nikolaos G. Papadopoulos, Annabelle Bédard, I. J. Ansotegui, Claus Bachert, Magnus Wickman, Michael Makris, J. Correia da Sousa, Emmanuel P. Prokopakis, Ana Todo-Bom, Enrica Menditto, Xavier Basagaña, W. J. Fokkens, Peter Hellings, Gabrielle L. Onorato, Sinthia Bosnic-Anticevich, D. Larenas-Linnemann, François Spertini, A. Valiulis, R. Emuzyte, M. T. Ventura, Sanna Toppila-Salmi, I. Annesi-Maesano, Maddalena Illario, Erkka Valovirta, Bedard, A., Basagana, X., Anto, J. M., Garcia-Aymerich, J., Devillier, P., Arnavielhe, S., Bedbrook, A., Onorato, G. L., Czarlewski, W., Murray, R., Almeida, R., Fonseca, J. A., Correia da Sousa, J., Costa, E., Morais-Almeida, M., Todo-Bom, A., Cecchi, L., De Feo, G., Illario, M., Menditto, E., Monti, R., Stellato, C., Ventura, M. T., Annesi-Maesano, I., Bosse, I., Fontaine, J. F., Pham-Thi, N., Thibaudon, M., Schmid-Grendelmeier, P., Spertini, F., Chavannes, N. H., Fokkens, W. J., Reitsma, S., Dubakiene, R., Emuzyte, R., Kvedariene, V., Valiulis, A., Kuna, P., Samolinski, B., Klimek, L., Mosges, R., Pfaar, O., Shamai, S., Roller-Wirnsberger, R. E., Tomazic, P. V., Ryan, D., Sheikh, A., Haahtela, T., Toppila-Salmi, S., Valovirta, E., Cardona, V., Mullol, J., Valero, A., Makris, M., Papadopoulos, N. G., Prokopakis, E. P., Psarros, F., Bachert, C., Hellings, P. W., Pugin, B., Bindslev-Jensen, C., Eller, E., Kull, I., Melen, E., Wickman, M., De Vries, G., van Eerd, M., Agache, I., Ansotegui, I. J., Bosnic-Anticevich, S., Cruz, A. A., Casale, T., Ivancevich, J. C., Larenas-Linnemann, D. E., Sofiev, M., Wallace, D., Waserman, S., Yorgancioglu, A., Laune, D., Bousquet, J., Laboratoire de recherche sur les mécanismes moléculaires et pharmacologiques de l’obstruction bronchique (LOBIP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), KYomed INNOV [Montpellier], CHU Montpellier, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Département Centre de Soins d'enseignement et de recherche dentaires [CHU Montpellier], Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Université de Montpellier (UM), Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), Sorbonne Université (SU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Allergist [La Rochelle], Allergist [Reims], Institut de Recherche Biomédicale des Armées, Département Neurosciences et Contraintes Opérationnelles, Unité de Neurophysiologie du Stress, 92123 Brétignysur- Orge cedex, France (IRBA), Institut de Recherche Biomédicale des Armées, Département Neurosciences et Contraintes Opérationnelles, Unité de Neurophysiologie du Stress, Réseau National de Surveillance Aérobiologique (RNSA), Vieillissement et Maladies chroniques : approches épidémiologique et de santé publique (VIMA), and Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)
Subjects: Allergy, IMPACT, Respiratory Medicine and Allergy, Review, Allergic rhinitis, 0302 clinical medicine, Anti-histamines, Corticosteroids, ICT, MASK, Mobile health, Treatment, Allergic symptoms, Medicine and Health Sciences, Immunology and Allergy, Medicine, Corticosteroid, [SDV.IMM.ALL]Life Sciences [q-bio]/Immunology/Allergology, Lungmedicin och allergi, 0303 health sciences, Anti-histamine, IMPAIRMENT, 3. Good health, Life Sciences & Biomedicine, medicine.drug, Pulmonary and Respiratory Medicine, Immunology, AZELASTINE/FLUTICASONE, Mometasone furoate, PERSON-CENTERED CARE, Fluticasone propionate, 03 medical and health sciences, INTERMITTENT, Allergic rhiniti, 030304 developmental biology, Asthma, Science & Technology, Pollen season, business.industry, GUIDANCE, AIR-POLLUTION, medicine.disease, SEVERITY, 030228 respiratory system, ASTHMA, Observational study, business, Demography
Abstract: Background The analysis of mobile health (mHealth) data has generated innovative insights into improving allergic rhinitis control, but additive information is needed. A cross-sectional real-world observational study was undertaken in 17 European countries during and outside the estimated pollen season. The aim was to collect novel information including the phenotypic characteristics of the users. Methods The Allergy Diary–MASK-air–mobile phone app, freely available via Google Play and App, was used to collect the data of daily visual analogue scales (VASs) for overall allergic symptoms and medication use. Fluticasone Furoate (FF), Mometasone Furoate (MF), Azelastine Fluticasone Proprionate combination (MPAzeFlu) and eight oral H1-antihistamines were studied. Phenotypic characteristics were recorded at entry. The ARIA severity score was derived from entry data. This was an a priori planned analysis. Results 9037 users filled in 70,286 days of VAS in 2016, 2017 and 2018. The ARIA severity score was lower outside than during the pollen season. Severity was similar for all treatment groups during the pollen season, and lower in the MPAzeFlu group outside the pollen season. Days with MPAzeFlu had lower VAS levels and a higher frequency of monotherapy than the other treatments during the season. Outside the season, days with MPAzeFlu also had a higher frequency of monotherapy. The number of reported days was significantly higher with MPAzeFlu during and outside the season than with MF, FF or oral H1-antihistamines. Conclusions This study shows that the overall efficacy of treatments is similar during and outside the pollen season and indicates that medications are similarly effective during the year.
Published: 2020
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7. 1714P Edmonton symptom assessment system (ESAS)-total care (TC): Development and psychometric validation in Italian language of ESAS-TC in patients undergoing cancer treatment and follow-up

Author: Carla Ripamonti, Francesca Chiesi, G. De Feo, G. Miccinesi, Luisa Toffolatti, P. Di Pede, D. La Carpia, R. Leporati, and Mauro Guglielmo
Subjects: Pediatrics, medicine.medical_specialty, Oncology, business.industry, Italian language, medicine, Total care, In patient, Hematology, Symptom assessment, business, Cancer treatment
Published: 2021
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8. A procedure for evaluating the most environmentally sound alternative between two on-site small-scale wastewater treatment systems

Author: Carmen Ferrara and G. De Feo
Subjects: Engineering, Strategy and Management, Small-scale, 010501 environmental sciences, Activated sludge, Constructed wetland, Electricity, LCA, LLDPE, 01 natural sciences, Industrial and Manufacturing Engineering, Life-cycle assessment, 0505 law, 0105 earth and related environmental sciences, General Environmental Science, Ecological footprint, Waste management, Renewable Energy, Sustainability and the Environment, Impact assessment, business.industry, 05 social sciences, Recipe, Photovoltaic system, Environmental engineering, 050501 criminology, Sewage treatment, business
Abstract: The main aim of this study was to evaluate, in the design phase, the most environmentally sound alternative between two on-site small-scale wastewater treatment systems (designed for 15 inhabitants), namely an activated sludge compact system and a constructed wetland system (both in linear low-density polyethylene), using Life Cycle Assessment. The procedure considered three sensitive parameters with three values. All the 27 combinations were evaluated with three different impact assessment methods (generating 81 comparison cases): IPCC 2007 100 years, Ecological Footprint and ReCiPe 2008 H. The constructed wetland system was the best environmental choice in 93% of the cases. Realizing the two treatment systems in different European countries, the activated sludge system would be the best environmental choice in some cases. Considering the production of electricity with photovoltaic systems, the total impact of the activated sludge system, evaluated with the ReCiPe 2008 H method, would be smaller than that of the constructed wetland system. The variation of the operating lifetime parameter had a major influence on the constructed wetland system, where the greatest consumption of energy and resources occurs during the construction phase. There were significant differences among the results with ReCiPe 2008 H and those with Ecological Footprint and IPCC 2007 100 years. Therefore, in a Life Cycle Assessment study, it would be preferable to adopt several impact assessment methods in order to verify how the results can vary.
Published: 2017
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9. Transfer of innovation on allergic rhinitis and asthma multimorbidity in the elderly ( <scp>MACVIA</scp> ‐ <scp>ARIA</scp> ) ‐ <scp>EIP</scp> on <scp>AHA</scp> Twinning Reference Site ( <scp>GARD</scp> research demonstration project)

Author: Alan Estrada-Cardona, Désirée Larenas-Linnemann, A. A. Cruz, A. Bedbrook, Torsten Zuberbier, B. De Martino, Esben Eller, K. C. Bergmann, A. Farsi, Ana Maria Carriazo, João Fonseca, Manuel Teixeira Veríssimo, Carsten Bindslev-Jensen, S. La Grutta, G. De Feo, Rimantas Stukas, M Doulapsi, Jean-Louis Pépin, Adnan Custovic, Gabrielle L. Onorato, Oliver Pfaar, U. Trama, Timo E. Strandberg, Ana Margarida Pereira, M. Bochenska Marciniak, V. Tibaldi, M. H. Garcia Cruz, Juan Carlos Ivancevich, Alessandro Vatrella, Denis Caillaud, Tuula Vasankari, J. A. Rizzo, Robyn E O'Hehir, Anne Lise Courbis, D. Lauri, Benoit Pugin, José Luis Gálvez-Romero, Juan José Matta-Campos, Jean Bousquet, G. De Vries, Johanna Salimäki, A. Yorgancioglu, A. Ciceran, C. Dario, Luc Colas, W. J. Fokkens, J. Millot-Keurinck, Josep M. Antó, I. Annesi-Maesano, F. Corti, Nick A. Guldemond, Renzo Angles, Arūnas Valiulis, Vicky Kritikos, Martin Wagenmann, J Mullol, G. Canfora, Peter Hellings, M. T. Ventura, Bilun Gemicioglu, Martín Bedolla-Barajas, Elísio Costa, M. Guidacci, Milan Sova, Isabelle Bosse, Jesús Guillermo Espinoza-Contreras, D. Conforti, J. Correia de Sousa, M. Sorlini, Massimo Triggiani, Jorge Maspero, Maciej Kupczyk, Rachel Tan, Jean-François Ferrero, D Caiazza, N. Di Carluccio, O. Kalayci, L. Lewis, Javier Gómez-Vera, Antoine Magnan, J. Farrell, T. Dedeu, I. Bogus-Buczynska, J. Just, Erkka Valovirta, Frederic Viart, Daniel Laune, Marco Nalin, Regina Roller-Wirnsberger, A. Szylling, Caterina Bucca, G. Castellano, Davide Caimmi, V. Stroetmann, Filip Raciborski, Rafael Stelmach, Luiana Hernández-Velázquez, Violeta Kvedariene, E. Bacci, Maurizio Romano, Cemal Cingi, A. C. Pozzi, Marit Westman, I. Young, S. Forti, M. T. Burguete Cabañas, Bolesław Samoliński, Ruta Dubakiene, E. Zernotti, A. Blua, Ioana Agache, B. A. Barreto, João O. Malva, J. Lavrut, Thomas Keil, Miguel Alejandro Medina-Ávalos, C. I. García-Cobas, Jorge A. Luna-Pech, J. F. Fontaine, R. Emuzyte, Biljana Cvetkovski, Ruth Murray, Giovanni Rolla, Antonella Muraro, Jussi Karjalainen, H. Neffen, E Cousein, Claus Bachert, V. Kolek, Magnus Wickman, Elaine Colgan, Mario R. Romano, Miguel A. Sierra, Erik Melén, A. Senn, Paulo Augusto Moreira Camargos, C. Cartier, Jawad Hajjam, Ali Fuat Kalyoncu, S. Shamai, Sinthia Bosnic-Anticevich, L. Cecci, Renaud Louis, Ana Todo-Bom, Rodolphe Bourret, Enrica Menditto, Nikolaos G. Papadopoulos, M. M. Ciaravolo, Emmanuel P. Prokopakis, G. Passalacqua, P. V. Tomazic, Edgardo Jares, C. Robalo-Cordeiro, L. Bertorello, M. Bewick, Roland Buonaiuto, A. Romano, Sîan A Williams, Anabela Mota-Pinto, Marcello Persico, Luigi Napoli, M. Lessa, Ralph Mösges, G. Levato, M. Nogues, Tari Haahtela, Edyta Krzych-Fałta, Janet Rimmer, F. de Blay, A. Zurkuhlen, Ludger Klimek, I. Baroni, Niels H. Chavannes, Faradiba Sarquis Serpa, T. Bieber, E. Asayag, Yves Dauvilliers, Piotr Lacwik, R. M. Cortés-Grimaldo, Piotr Kuna, Cristiana Stellato, A Valero, J. da Silva, M. Illario, S Birov, R. Gerth van Wijk, M. R. Aliberti, Inger Kull, Z. Gutter, Sanna Toppila-Salmi, Gérard Dray, Sylvie Arnavielhe, Victoria Cardona, M. Morais-Almeida, Guy Joos, S. Di Capua Ercolano, J. Coll, M. van Eerd, C. Wanscher, N. Khaltaev, Agnieszka Lipiec, Mónica Rodríguez-González, Oscar Mayora, Pascal Demoly, G. Moda, S. Palkonen, I. Lieten, and B. De Oliviera
Subjects: Gerontology, Allergy, Carat, medicine.medical_specialty, Visual analogue scale, business.industry, Immunology, Alternative medicine, medicine.disease, Comorbidity, 03 medical and health sciences, 0302 clinical medicine, Quality of life (healthcare), 030228 respiratory system, medicine, Physical therapy, Immunology and Allergy, Multimorbidity, 030212 general & internal medicine, business, health care economics and organizations, Asthma
Abstract: The overarching goals of the European Innovation Partnership on Active and Healthy Ageing (EIP on AHA) are to enable European citizens to lead healthy, active and independent lives whilst ageing. The EIP on AHA includes 74 Reference Sites. The aim of this study was to transfer innovation from an app developed by the MACVIA-France EIP on AHA reference site (Allergy Diary) to other reference sites. The phenotypic characteristics of rhinitis and asthma multimorbidity in adults and the elderly will be compared using validated information and communication technology (ICT) tools (i.e. the Allergy Diary and CARAT: Control of Allergic Rhinitis and Asthma Test) in 22 Reference Sites or regions across Europe. This will improve the understanding, assessment of burden, diagnosis and management of rhinitis in the elderly by comparison with an adult population. Specific objectives will be: (i) to assess the percentage of adults and elderly who are able to use the Allergy Diary, (ii) to study the phenotypic characteristics and treatment over a 1-year period of rhinitis and asthma multimorbidity at baseline (cross-sectional study) and (iii) to follow-up using visual analogue scale (VAS). This part of the study may provide some insight into the differences between the elderly and adults in terms of response to treatment and practice. Finally (iv) work productivity will be examined in adults.
Published: 2017
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10. The Augustan aqueduct of Capua and its historical evolution

Author: Bruno Miccio, G. De Feo, Giacinto Libertini, and Nino Leone
Subjects: Engineering, business.industry, media_common.quotation_subject, 0208 environmental biotechnology, Water supply, Empire, Aqueduct, Context (language use), Aqueducts, 02 engineering and technology, Ancient history, Aqua Iulia, Carolino aqueduct, 020801 environmental engineering, Water infrastructure, Roman, Carmignano aqueduct, Capua, business, Water Science and Technology, media_common
Abstract: At his own expense Augustus built his own aqueduct, known as Aqua Iulia, for Capua, located in today's Campania region of southern Italy, which was in Roman times, one of the most important civitas of the empire. The course of this aqueduct and of its likely branches, destined for two small towns, Saticula and Calatia, is hypothesized, in part based on the re-use in the seventeenth century of about 8 miles (i.e. 11.8 km) of the ancient aqueduct for another water supply that served Naples, namely the Carmignano aqueduct. The subsequent transformation in the eighteenth century in a new water supply along a new route at a higher altitude is described. This third water supply served the Bourbon royal palace of Caserta, a magnificent construction built in the same period. In summary, the historical evolution of the Augustan aqueduct of Capua is discussed in the context of the communities served and in the context of the organization and history of the territory supplied, demonstrating the richness of information that may be obtained by an integrated study of the transformation, over time, of this important water infrastructure.
Published: 2017
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11. Use of sunflower seed fried oil as an ecofriendly plasticizer for starch and application of this thermoplastic starch as a filler for PLA

Author: Roberto Pantani, I. De Marco, G. De Feo, and Valentina Volpe
Subjects: Thermoplastic, Materials science, food.ingredient, Starch, 02 engineering and technology, 010402 general chemistry, 01 natural sciences, chemistry.chemical_compound, food, Glycerol, Poly(lactic) acid, Food science, Thermoplastic starch, chemistry.chemical_classification, Sunflower oil, Plasticizer, food and beverages, Biodegradation, 021001 nanoscience & nanotechnology, 0104 chemical sciences, chemistry, Sustainability, Compounding, Sunflower seed, 0210 nano-technology, Agronomy and Crop Science
Abstract: The high cost of the Poly(lactic) Acid when compared to its durable competitors is a significant drawback that inhibits its diffusion for many industrial applications. A common solution is the compounding with other polymers that preserve biodegradability, and thermoplastic starch (TPS) is a conventional choice. The innovation proposed in this work is to replace into the starch plasticization process part of the glycerol with a sunflower seed oil resulting from the frying process in a fast food. The so plasticized TPS was compared to the TPS plasticized with only glycerol and then mixed to the PLA. The replacement of a certain percentage of glycerol with fried edible sunflower oil as plasticizer for starch results in an improvement in material properties of the TPS and does not change the properties of the PLA/TPS blends. Plasticization of starch with fried oil has been proven to be the most environmentally sound solution also from a Life Cycle Assessment.
Published: 2018

12. Omalizumab in elderly patients with chronic spontaneous urticaria: An Italian real-life experience

Author: Erminia Ridolo, Eustachio Nettis, A. Pannofino, Gianenrico Senna, Stefano Pucci, Alessia Gatta, Danilo Villalta, Enrico Heffler, Anna Radice, A. Romano, S. D'Alò, A. D'Angelo, M. Di Gioacchino, Mona-Rita Yacoub, Riccardo Senter, Sebastiano Gangemi, Elisabetta Di Leo, Michela Mineni, G. Stefanizzi, A. Martignago, Maria Pia Conte, S. Fichera, Luigi Macchia, Francesco Gaeta, A. Vignoli, Ilaria Baiardini, Enrico Maggi, Giuseppe Spadaro, A de Paulis, Donatella Macchia, Giselda Colombo, Angelo Vacca, Walter Canonica, Silvia Peveri, Maria Teresa Costantino, E. Favero, Eleonora Savi, Luca Cegolon, I. Zaza, F. Lodi Rizzini, S. Capretti, Mauro Cancian, Paola Lucia Minciullo, Oliviero Rossi, G. De Feo, M. Bisaccia, L. La Rosa, Roberta Parente, Aikaterini Detoraki, Nettis, Eustachio, Cegolon, Luca, Di Leo, Elisabetta, Canonica, Walter Giorgio, Detoraki, Aikaterini, Baiardini, I., Bisaccia, M., Cancian, M., Capretti, S., Colombo, G., Conte, M., Costantino, M. T., D'Alò, S., D'Angelo, A., De Feo, G., Di Gioacchino, M., Favero, E., Fichera, S., Gaeta, F., Gangemi, S., Gatta, A., Heffler, E., La Rosa, L., Lodi Rizzini, F., Macchia, D., Macchia, L., Maggi, E., Martignago, A., Minciullo, P., Mineni, M., Pannofino, A., Parente, R., Peveri, S., Pucci, S., Radice, A., Ridolo, E., Romano, A., Rossi, O., Savi, E., Senna, G. E., Senter, R., Spadaro, G., Stefanizzi, Antonio, Vacca, A., Vignoli, A., Villalta, D. R., Yacoub, M., Zaza, I., Nettis, E., Cegolon, L., Di Leo, E., Canonica, W. G., Detoraki, A., D'Alo, S., and Stefanizzi, G.
Subjects: Adult, Male, Pulmonary and Respiratory Medicine, medicine.medical_specialty, Adolescent, Urticaria, Immunology, Chronic spontaneous urticaria, omalizumab, elderly patients, Drug Resistance, Drug resistance, Omalizumab, 030207 dermatology & venereal diseases, 03 medical and health sciences, Young Adult, 0302 clinical medicine, Internal medicine, Anti-Allergic Agents, 80 and over, medicine, Humans, Immunology and Allergy, In patient, Young adult, Adverse effect, Aged, Aged, 80 and over, Chronic Disease, Female, Histamine H1 Antagonists, Middle Aged, Treatment Outcome, Histamine H1 Antagonist, Study drug, Angioedema, business.industry, Anti-Allergic Agent, 030228 respiratory system, Observational study, medicine.symptom, business, medicine.drug, Human
Abstract: Background Omalizumab therapy is effective and safe in patients with chronic spontaneous urticaria (CSU) resistant to nonsedating histamine 1 (H 1 ) antihistamines (nsAHs). Objective To evaluate the efficacy and safety of omalizumab in elderly (aged ≥65 years) patients with nonsedating H 1 -antihistamine–refractory CSU in a real-life setting. Methods Patients with nonsedating H 1 -antihistamine–refractory CSU (n = 322) treated with omalizumab administered every 4 weeks in doses of 300 mg for 24 weeks were divided into 2 groups according to age at omalizumab treatment onset: 15 to 64 years and 65 years or older. Treatment response was assessed using a 7-day urticaria activity score (UAS7). Adverse effects of omalizumab therapy were recorded. Results Among patients, 32 (9.9%) were 65 years or older. At baseline, CSU characteristics were generally similar among the groups, although the presence of angioedema was statistically significantly lower in patients younger than 65 years. Any differences in weekly itch severity score, hive score, and UAS7 between the 2 age groups were not significant at weeks 4, 12, and 24, with the exception of the hive score at 24 weeks and the UAS7 at week 24. No significant between-group differences were seen in the proportion of patients with a UAS7 of 6 or lower and with a UAS7 score of 0 at weeks 4, 12, 24, and 40. The proportion of patients with at least one adverse event reported as suspected to be caused by study drug was 10% in the younger group vs 6.3% in the older group ( P = .53). Conclusion Our study found that omalizumab is a well-tolerated and effective therapy for elderly patients with nonsedating H 1 -antihistamine–refractory CSU.
Published: 2018

13. Allergic Rhinitis and its Impact on Asthma (ARIA) Phase 4 (2018): Change management in allergic rhinitis and asthma multimorbidity using mobile technology

Author: Karin C. Lødrup Carlsen, L. Cecchi, F. Portejoie, T. Vontetsianos, Olivier Vandenplas, M. van Hague, D. Mora Bogado, M. Illario, Dana Wallace, L. Namazova-Baranova, E. Asayag, I. Ribeirinho, E. Costa, Shona Pedersen, Inger Kull, Davor Plavec, M. Morais-Almeida, Mickael Bewick, N.H. Chavannes, I. J. Ansotegui, G. De Carlo, K. S. Bennoor, Faradiba Sarquis Serpa, S. Arnavielle, F. Corti, Moises A. Calderon, Martín Bedolla-Barajas, Mette Sørensen, Isabella Annesi-Maesano, Elaine Colgan, Przemyslaw Kardas, M. van Eerd, Jorge Maspero, Valérie Siroux, Isabelle Momas, Ralph Mösges, Yves Dauvilliers, T. Keil, T. Bieber, Marit Westman, Rachel Nadif, O. Pfaar, A.C. Carvalho Coehlo, R. M. Cortés-Grimaldo, I. Skrindo, Piotr Kuna, Nicola Scichilone, Antonella Muraro, Kimihiro Okubo, Paulo Augusto Moreira Camargos, C. Cartier, Oliver Pfaar, K. Ohta, Barbara P. Yawn, Igor Kaidashev, Michel Thibaudon, X. Basagana, I. Kaidashev, Bilun Gemicioglu, S. Genova, Hae-Sim Park, J.J. Matta Campos, Simon Walker, Ulf Darsow, Fulvio Braido, J. Salimäki, T. Zuberbier, Raphaël Chiron, Mohammad Reza Masjedi, G.D. Marshall, Branislava Milenkovic, W. J. Fokkens, Eric D. Bateman, Robert M. Naclerio, Steve Montefort, M. de Fátima Emerson, T. Werfel, Cemal Cingi, A. Szylling, Martin Wagenmann, I. Baiardini, L. T. T. Le, N. Khaltaev, Ki-Suck Jung, Agnieszka Lipiec, Panayiotis K. Yiallouros, A Valero, R. Gerth van Wijk, L. Hernández, Marek L. Kowalski, C. Zubrinich, Sinthia Bosnic-Anticevich, Miguel A. Sierra, Erik Melén, T. Haahtela, Rute Almeida, Violeta Kvedariene, R. Pawankar, T.A. Popov, Flore Amat, Sanna Toppila-Salmi, M. Gotua, A. Sheikh, A. Bedbrook, Torsten Zuberbier, B. De Martino, Gérard Dray, Francesca Avolio, E. Mandajieva, B. Samolinski, Petr Panzner, P. Kuna, Philippe-Jean Bousquet, T. D. Nyembue, Luo Zhang, Leyla Namazova-Baranova, Ana Maria Carriazo, João Fonseca, E. Van Ganse, Roland Buhl, M. Bochenska Marciniak, Cristiana Stellato, J. da Silva, J. E. Gereda, Han-Jung Park, M.C. Costa-Dominguez, W. Carr, Dirceu Solé, S. Forti, Nanshan Zhong, Jordi Sunyer, Alain Didier, Y. Z. Chen, Thomas B. Casale, Jim Phillips, Isabelle Bosse, Manuel Teixeira Veríssimo, D. Y. Wang, U. Trama, Cristina Bárbara, David Somekh, T. Camuzat, R. N. Naclerio, Enrico Novellino, Leszek Klimek, M. Rodriguez Gonzalez, Holger J. Schünemann, Mario Barbagallo, D. Larenas-Linnemann, Mario Sánchez-Borges, Massimo Triggiani, Y. Okamoto, E. Mathieu-Dupas, N. Di Carluccio, S. Toppila-Salmi, Omer Kalayci, Rudolf Valenta, J. Coll, F. de Blay, Wienczyslawa Czarlewski, W. Pohl, Piotr Wroczyński, Kian Fan Chung, Nikolaos G. Papadopoulos, Pascal Demoly, Hubert Blain, M. Crescenzo, O. Kalayci, Leocadio Rodríguez-Mañas, G. Moda, L. Cox, Z. Gutter, A. Mair, Andrew Bush, Maria-Dolores Mogica-Martinez, Giorgio Walter Canonica, Antonio Valero, Daniel Laune, A. Zurkuhlen, Paul C. Potter, D. Wallace, Gabrielle L. Onorato, Mihaela Zidarn, E.P. Prokopakis, Anne Lise Courbis, Sergio Bonini, Ruta Dubakiene, A. Papi, Y. El-Gamal, Jacques Mercier, Wytske Fokkens, Rodolphe Bourret, S. Palkonen, A. Yorgancioglu, G. Vezzani, J. A. Rizzo, D. Plavec, D. Caillot, G. De Feo, E. Menditto, Caterina Bucca, A. C. Pozzi, Hironori Sagara, I. Grisle, I. Pin, Christopher E. Brightling, Ludger Klimek, F.F. Morato-Castro, Désirée Larenas-Linnemann, Alessandro Vatrella, A. A. Cruz, Guy Joos, E.D. Bateman, Erendira Rodriguez-Zagal, H. Douagui, T. To, Edgardo Jares, C. Bindslev-Jensen, G. Levato, J. O. B. Hourihane, R. Rajabian-Soderlund, C. Odzhakova, J. Bousquet, M. T. Ventura, Arzu Yorgancioglu, Osman M. Yusuf, H. J. Zar, Giovanni Rolla, Sebastian L. Johnston, M.S. Dykewicz, Esben Eller, A. Gamkrelidze, Filip Raciborski, Renzo Angles, Rafael Stelmach, M. Nogues, David Price, Mário Morais-Almeida, Tari Haahtela, Teresa To, D. Conforti, Stephen R. Durham, S. Gonzalez Diaz, V. Cardona, Werner Aberer, B. Milenkovic, Luigi Napoli, K. C. Bergmann, P W Hellings, M. Lessa, P. Panzner, Alfonso M. Cepeda Sarabia, M. Guidacci, A.L. Matos, Todor A. Popov, C. Suppli Ulrik, Diana Deleanu, N. de Paula Motta Rubini, Carsten Bindslev-Jensen, I. Majer, Ioana Agache, B. A. Barreto, R. Picard, Erkka Valovirta, A. Fink-Wagner, L. Colas, João O. Malva, Thomas Keil, M. T. Burguete Cabañas, Bolesław Samoliński, M.H. Garcia-Cruz, L.P. Boulet, K. Nekam, Edyta Krzych-Fałta, P. Devillier, J. Ferreira de Mello, Jussi Karjalainen, I. Bogus-Buczynska, Susan Waserman, Marcus Maurer, Tomas Chivato, Elena Bacci, M. Przemecka, Olga Lourenço, José Miguel Fuentes-Pérez, M. Zidarn, Talant Sooronbaev, J.M. Anto, W. Czarlewski, R. Murray, Luís Nogueira-Silva, G. Passalacqua, E. Chkhartishvili, Oscar Mayora, Victoria Cardona, M. Sondermann, Piotr Lacwik, S. Ouedraogo, I. Baroni, Artur Z. Białoszewski, G Scadding, J. Strozek, R. Emuzyte, Neven Miculinic, Ruby Pawankar, Ken Ohta, I. Agache, J.L. Gálvez-Romero, Nikos G. Papadopoulos, E. O. Meltzer, I. Annesi-Maesano, E. De Manuel Keenoy, Jorge A. Luna-Pech, Ana Margarida Pereira, Paul Potter, M. Ortega Cisneros, J. Li, K. F. Rabe, M. Rottem, Mikael Benson, Ali Fuat Kalyoncu, Dermot Ryan, Dieter Maier, C.Y. García-Cobas, S. Bialek, G. Du Toit, S. Shamai, S. Mavale-Manuel, Rojin Rajabian-Soderlund, Maddalena Illario, Philippe Devillier, F. Rodenas, Emmanuel P. Prokopakis, De Yun Wang, Niels H. Chavannes, E.H.D. Bel, Bianca Beghe, Sietze Reitsma, John Wright, O. Lourenço, L.T.T. Le, Josep M. Antó, T. Casale, Paul K. Keith, K. C. Lødrup Carlsen, P. Demoly, Mikael Kuitunen, Marc Humbert, A. M. Cepeda Sarabia, Ignacio J. Ansotegui, M.C. Rizzo, Davide Caimmi, Milan Sova, Nick A. Guldemond, P. Yakovliev, Judah A. Denburg, Jaime Correia de Sousa, Elisabete Melo-Gomes, Aziz Sheikh, I. Bosse, M. M. Ciaravolo, S. Di Capua Ercolano, Alpana Mair, P. Lieberman, Isabella Pali-Schöll, Leif Bjermer, G. De Vries, M. Roman Rodriguez, Johanna Salimäki, Carmen Panaitescu, F. Mihaltan, Giulia De Feo, F. E. R. Simons, A. Blua, B. Mahboub, D. Ryan, M. Bewick, Anabela Mota-Pinto, J.A. Fonseca, Neil Wilson, Marek Jutel, Dennis M. Williams, M. Akdis, Menachem Rottem, Marcello Persico, J. C. Ivancevich, Nelson Rosario, A. Farsi, Alvaro A. Cruz, Liguo Zhang, Anna Bedbrook, L. Bertorello, Magnus Wickman, Marilyn Urrutia-Pereira, O. Spranger, René Maximiliano Gómez, C. Bachert, Renaud Louis, Musa Khaitov, C. Stellato, Constantinos Pitsios, Roland Buonaiuto, A. Romano, Sîan A Williams, R. Puy, Daniela Rivero-Yeverino, Y. Mohammad, J. Farrell, Jan Brozek, Ricardo Pio Monti, E. Paulino, J. Correia de Sousa, Miguel Alejandro Medina-Ávalos, Jocelyne Just, Peter Valentin Tomazic, Jean-François Ferrero, Antoine Magnan, S. Waserman, J Rosado-Pinto, Maciek Kupczyk, C.S. Bosnic-Anticevich, T. Dedeu, Tommi Vasankari, R. Mösges, Robin O'Hehir, Ema Paulino, Peter Hellings, A. Neou, M. Wickman, D. Lauri, Jean Bousquet, A. Ciceran, Jacques Bouchard, Yehia El-Gamal, M.G. Dominguez-Silva, M.R. Alberti, Jean-Louis Pépin, Kimi Okubo, Juan Carlos Ivancevich, Patrik Eklund, Benoit Pugin, C. Dario, Mussa Khaitov, Luisa Brussino, A.G. Chuchalin, Elísio Costa, Susanna Palkonen, Lars Münter, Pedro Carreiro-Martins, R.E. Pulido Ross, Ettore Novellino, Kai-Håkon Carlsen, María Antonieta Guzmán, G.W. Canonica, Gabriel Onorato, Giuseppe De Carlo, R.E. Roller-Wirnsberger, Brian J. Lipworth, M. A. Guzman, J.N. Tebyriçá, Adnan Custovic, Yoshitaka Okamoto, Rimantas Stukas, P. Manning, J. Sastre-Dominguez, Caroline L.S. George, Robyn E O'Hehir, K. Maciej, Bassam Mahboub, J. F. Fontaine, Arũnas Valiulis, Xavier Rodó, D. Vicheva, G. Canfora, Vitalis Briedis, S. Rodrigues Valle, Mark S. Dykewicz, Joanne Rimmer, G. Castellano, B. Pigearias, A. L. Boner, Yunuen Rocío Huerta-Villalobos, Christine Rolland, H. Neffen, H. Arshad, Javier Gómez-Vera, P. Moura Santo, Frederic Viart, F. Blasi, J. Garcia-Aymerich, Lorenzo Cecchi, V. Niedeberger, Giorgio Ciprandi, F. Caballero-Fonseca, Jean-François Fontaine, J Mullol, Maurizio Romano, M. Viegi, Mario E. Zernotti, Arunas Valiulis, Anna Asarnoj, Antonio Nieto, J. Lavrut, D. Dokic, V. Kvedariene, Ewa Jassem, Cezmi A. Akdis, Ruth Murray, Claus Bachert, Peter Schmid-Grendelmeier, Emilie Burte, Joaquim Mullol, Guido Iaccarino, J. Kleine-Tebbe, P. V. Tomazic, E. Eller, Alessandro Fiocchi, H.J. Schunemann, M. Sorlini, C. Robalo-Cordeiro, Ana-Maria Todo-Bom, J. Brozek, Marco Nalin, Matteo Bonini, J. C. Sisul, S.E. Dahlen, F. Amat, Juan Carlos Sisul, Jawad Hajjam, Ana Todo-Bom, Enrica Menditto, Bousquet J., Hellings P.W., Agache I., Amat F., Annesi-Maesano I., Ansotegui I.J., Anto J.M., Bachert C., Bateman E.D., Bedbrook A., Bennoor K., Bewick M., Bindslev-Jensen C., Bosnic-Anticevich S., Bosse I., Brozek J., Brussino L., Canonica G.W., Cardona V., Casale T., Cepeda Sarabia A.M., Chavannes N.H., Cecchi L., Correia de Sousa J., Costa E., Cruz A.A., Czarlewski W., De Carlo G., De Feo G., Demoly P., Devillier P., Dykewicz M.S., El-Gamal Y., Eller E.E., Fonseca J.A., Fontaine J.-F., Fokkens W.J., Guzman M.-A., Haahtela T., Illario M., Ivancevich J.-C., Just J., Kaidashev I., Khaitov M., Kalayci O., Keil T., Klimek L., Kowalski M.L., Kuna P., Kvedariene V., Larenas-Linnemann D., Laune D., Le L.T.T., Carlsen K.L., Lourenco O., Mahboub B., Mair A., Menditto E., Milenkovic B., Morais-Almeida M., Mosges R., Mullol J., Murray R., Naclerio R., Namazova-Baranova L., Novellino E., O'Hehir R.E., Ohta K., Okamoto Y., Okubo K., Onorato G.L., Palkonen S., Panzner P., Papadopoulos N.G., Park H.-S., Paulino E., Pawankar R., Pfaar O., Plavec D., Popov T.A., Potter P., Prokopakis E.P., Rottem M., Ryan D., Salimaki J., Samolinski B., Sanchez-Borges M., Schunemann H.J., Sheikh A., Sisul J.-C., Rajabian-Soderlund R., Sooronbaev T., Stellato C., To T., Todo-Bom A.-M., Tomazic P.-V., Toppila-Salmi S., Valero A., Valiulis A., Valovirta E., Ventura M.-T., Wagenmann M., Wang D.Y., Wallace D., Waserman S., Wickman M., Yorgancioglu A., Zhang L., Zhong N., Zidarn M., Zuberbier T., Aberer W., Akdis C.A., Akdis M., Alberti M.R., Almeida R., Angles R., Arnavielle S., Asayag E., Asarnoj A., Arshad H., Avolio F., Bacci E., Baiardini I., Barbara C., Barbagallo M., Baroni I., Barreto B.A., Basagana X., Bedolla-Barajas M., Beghe B., Bel E.H., Bergmann K.C., Benson M., Bertorello L., Bialoszewski A.Z., Bieber T., Bialek S., Bjermer L., Blain H., Blasi F., Blua A., Bochenska Marciniak M., Bogus-Buczynska I., Boner A.L., Bonini M., Bonini S., Bouchard J., Boulet L.P., Bourret R., Braido F., Briedis V., Brightling C.E., Bucca C., Buhl R., Buonaiuto R., Panaitescu C., Burguete Cabanas M.T., Burte E., Bush A., Caballero-Fonseca F., Caillot D., Caimmi D., Calderon M.A., Camargos P.A.M., Camuzat T., Canfora G., Carreiro-Martins P., Carriazo A.M., Carr W., Cartier C., Castellano G., Chen Y., Chiron R., Chivato T., Chkhartishvili E., Chuchalin A.G., Chung K.F., Ciaravolo M.M., Ciceran A., Cingi C., Ciprandi G., Carvalho Coehlo A.C., Colas L., Colgan E., Coll J., Conforti D., Cortes-Grimaldo R.M., Corti F., Costa-Dominguez M.C., Courbis A.L., Cox L., Crescenzo M., Custovic A., Dahlen S.E., Dario C., da Silva J., Dauvilliers Y., Darsow U., De Blay F., Dedeu T., de Fatima Emerson M., De Vries G., De Martino B., de Paula Motta Rubini N., Deleanu D., Denburg J.A., Di Capua Ercolano S., Di Carluccio N., Didier A., Dokic D., Dominguez-Silva M.G., Douagui H., Dray G., Dubakiene R., Durham S.R., Du Toit G., Eklund P., Emuzyte R., Farrell J., Farsi A., Ferreira de Mello J., Ferrero J., Fink-Wagner A., Fiocchi A., Forti S., Fuentes-Perez J.M., Galvez-Romero J.L., Gamkrelidze A., Garcia-Aymerich J., Garcia-Cobas C.Y., Garcia-Cruz M.H., Gemicioglu B., Genova S., George C., Gereda J.E., Gerth van Wijk R., Gomez R.M., Gomez-Vera J., Gonzalez Diaz S., Gotua M., Grisle I., Guidacci M., Guldemond N.A., Gutter Z., Hajjam J., Hernandez L., Hourihane J.O., Huerta-Villalobos Y.R., Humbert M., Iaccarino G., Jares E.J., Jassem E., Johnston S.L., Joos G., Jung K.S., Jutel M., Kalyoncu A.F., Karjalainen J., Kardas P., Keith P.K., Khaltaev N., Kleine-Tebbe J., Kuitunen M., Kull I., Kupczyk M., Krzych-Falta E., Lacwik P., Lauri D., Lavrut J., Lessa M., Levato G., Li J., Lieberman P., Lipiec A., Lipworth B., Lodrup Carlsen K.C., Louis R., Luna-Pech J.A., Maciej K., Magnan A., Maier D., Majer I., Malva J., Mandajieva E., Manning P., De Manuel Keenoy E., Marshall G.D., Masjedi M.R., Maspero J.F., Mathieu-Dupas E., Matta Campos J.J., Matos A.L., Maurer M., Mavale-Manuel S., Mayora O., Medina-Avalos M.A., Melen E., Melo-Gomes E., Meltzer E.O., Mercier J., Miculinic N., Mihaltan F., Moda G., Mogica-Martinez M.D., Mohammad Y., Momas I., Montefort S., Monti R., Mora Bogado D., Morato-Castro F.F., Mota-Pinto A., Moura Santo P., Munter L., Muraro A., Nadif R., Nalin M., Napoli L., Neffen H., Niedeberger V., Nekam K., Neou A., Nieto A., Nogueira-Silva L., Nogues M., Nyembue T.D., Odzhakova C., Ortega Cisneros M., Ouedraogo S., Pali-Scholl I., Papi A., Passalacqua G., Pedersen S., Pepin J.L., Pereira A.M., Persico M., Phillips J., Picard R., Pigearias B., Pin I., Pitsios C., Pohl W., Portejoie F., Pozzi A.C., Price D., Puy R., Pugin B., Pulido Ross R.E., Przemecka M., Rabe K.F., Raciborski F., Reitsma S., Ribeirinho I., Rimmer J., Rivero-Yeverino D., Rizzo J.A., Rizzo M.C., Robalo-Cordeiro C., Rodenas F., Rodo X., Rodriguez Gonzalez M., Rodriguez-Manas L., Rolland C., Rodrigues Valle S., Roman Rodriguez M., Romano A., Rodriguez-Zagal E., Rolla G., Roller-Wirnsberger R.E., Romano M., Rosado-Pinto J., Rosario N., Sagara H., Sastre-Dominguez J., Scadding G.K., Scichilone N., Schmid-Grendelmeier P., Serpa F.S., Shamai S., Sierra M., Simons F.E.R., Siroux V., Skrindo I., Sole D., Somekh D., Sondermann M., Sova M., Sorensen M., Sorlini M., Spranger O., Stelmach R., Stukas R., Sunyer J., Strozek J., Szylling A., Tebyrica J.N., Thibaudon M., Trama U., Triggiani M., Suppli Ulrik C., Urrutia-Pereira M., Valenta R., van Eerd M., van Ganse E., van Hague M., Vandenplas O., Vezzani G., Vasankari T., Vatrella A., Verissimo M.T., Viart F., Viegi M., Vicheva D., Vontetsianos T., Walker S., Werfel T., Westman M., Williams D.M., Williams S., Wilson N., Wright J., Wroczynski P., Yakovliev P., Yawn B.P., Yiallouros P.K., Yusuf O.M., Zar H.J., Zernotti M.E., Zubrinich C., Zurkuhlen A., Bousquet, Jean, Hellings, Peter W., Agache, Ioana, Amat, Flore, Annesi-Maesano, Isabella, Ansotegui, Ignacio J., Anto, Josep M., Bachert, Clau, Bateman, Eric D., Bedbrook, Anna, Bennoor, Kazi, Bewick, Mickael, Bindslev-Jensen, Carsten, Bosnic-Anticevich, Sinthia, Bosse, Isabelle, Brozek, Jan, Brussino, Luisa, Canonica, Giorgio W., Cardona, Victoria, Casale, Thoma, Cepeda Sarabia, Alfonso M., Chavannes, Niels H., Cecchi, Lorenzo, Correia de Sousa, Jaime, Costa, Elisio, Cruz, Alvaro A., Czarlewski, Wienczyslawa, De Carlo, Giuseppe, De Feo, Giulia, Demoly, Pascal, Devillier, Philippe, Dykewicz, Mark S., El-Gamal, Yehia, Eller, Esben E., Fonseca, Joao A., Fontaine, Jean-Françoi, Fokkens, Wytske J., Guzmán, Maria-Antonieta, Haahtela, Tari, Illario, Maddalena, Ivancevich, Juan-Carlo, Just, Jocelyne, Kaidashev, Igor, Khaitov, Musa, Kalayci, Omer, Keil, Thoma, Klimek, Ludger, Kowalski, Marek L., Kuna, Piotr, Kvedariene, Violeta, Larenas-Linnemann, Desiree, Laune, Daniel, Le, Lan T. T., Carlsen, Karin Lodrup, Lourenço, Olga, Mahboub, Bassam, Mair, Alpana, Menditto, Enrica, Milenkovic, Branislava, Morais-Almeida, Mario, Mösges, Ralph, Mullol, Joaquim, Murray, Ruth, Naclerio, Robert, Namazova-Baranova, Leyla, Novellino, Ettore, O'Hehir, Robyn E., Ohta, Ken, Okamoto, Yoshitaka, Okubo, Kimi, Onorato, Gabrielle L., Palkonen, Susanna, Panzner, Petr, Papadopoulos, Nikos G., Park, Hae-Sim, Paulino, Ema, Pawankar, Ruby, Pfaar, Oliver, Plavec, Davor, Popov, Ted A., Potter, Paul, Prokopakis, Emmanuel P., Rottem, Menachem, Ryan, Dermot, Salimäki, Johanna, Samolinski, Boleslaw, Sanchez-Borges, Mario, Schunemann, Holger J., Sheikh, Aziz, Sisul, Juan-Carlo, Rajabian-Söderlund, Rojin, Sooronbaev, Talant, Stellato, Cristiana, To, Teresa, Todo-Bom, Ana-Maria, Tomazic, Peter-Valentin, Toppila-Salmi, Sanna, Valero, Antonio, Valiulis, Aruna, Valovirta, Erkka, Ventura, Maria-Teresa, Wagenmann, Martin, Wang, De Yun, Wallace, Dana, Waserman, Susan, Wickman, Magnu, Yorgancioglu, Arzu, Zhang, Luo, Zhong, Nanshan, Zidarn, Mihaela, Zuberbier, Torsten, Bousquet, J., Hellings, P. W., Aberer, W., Agache, I., Akdis, C. A., Akdis, M., Alberti, M. R., Almeida, R., Amat, F., Angles, R., Annesi-Maesano, I., Ansotegui, I. J., Anto, J. M., Arnavielle, S., Asayag, E., Asarnoj, A., Arshad, H., Avolio, F., Bacci, E., Bachert, C., Baiardini, I., Barbara, C., Barbagallo, M., Baroni, I., Barreto, B. A., Basagana, X., Bateman, E. D., Bedolla-Barajas, M., Bedbrook, A., Bewick, M., Beghé, B., Bel, E. H., Bergmann, K. C., Bennoor, K. S., Benson, M., Bertorello, L., Białoszewski, A. Z., Bieber, T., Bialek, S., Bindslev-Jensen, C., Bjermer, L., Blain, H., Blasi, F., Blua, A., Bochenska Marciniak, M., Bogus-Buczynska, I., Boner, A. L., Bonini, M., Bonini, S., Bosnic-Anticevich, C. S., Bosse, I., Bouchard, J., Boulet, L. P., Bourret, R., Bousquet, P. J., Braido, F., Briedis, V., Brightling, C. E., Brozek, J., Bucca, C., Buhl, R., Buonaiuto, R., Panaitescu, C., Burguete Cabañas, M. T., Burte, E., Bush, A., Caballero-Fonseca, F., Caillot, D., Caimmi, D., Calderon, M. A., Camargos, P. A. M., Camuzat, T., Canfora, G., Canonica, G. W., Cardona, V., Carlsen, K. H., Carreiro-Martins, P., Carriazo, A. M., Carr, W., Cartier, C., Casale, T., Castellano, G., Cecchi, L., Cepeda Sarabia, A. M., Chavannes, N. H., Chen, Y., Chiron, R., Chivato, T., Chkhartishvili, E., Chuchalin, A. G., Chung, K. F., Ciaravolo, M. M., Ciceran, A., Cingi, C., Ciprandi, G., Carvalho Coehlo, A. C., Colas, L., Colgan, E., Coll, J., Conforti, D., Correia de Sousa, J., Cortés-Grimaldo, R. M., Corti, F., Costa, E., Costa-Dominguez, M. C., Courbis, A. L., Cox, L., Crescenzo, M., Cruz, A. A., Custovic, A., Czarlewski, W., Dahlen, S. E., Dario, C., da Silva, J., Dauvilliers, Y., Darsow, U., De Blay, F., De Carlo, G., Dedeu, T., de Fátima Emerson, M., De Feo, G., De Vries, G., De Martino, B., de Paula Motta Rubini, N., Deleanu, D., Demoly, P., Denburg, J. A., Devillier, P., Di Capua Ercolano, S., Di Carluccio, N., Didier, A., Dokic, D., Dominguez-Silva, M. G., Douagui, H., Dray, G., Dubakiene, R., Durham, S. R., Du Toit, G., Dykewicz, M. S., El-Gamal, Y., Eklund, P., Eller, E., Emuzyte, R., Farrell, J., Farsi, A., Ferreira de Mello, J., Ferrero, J., Fink-Wagner, A., Fiocchi, A., Fokkens, W. J., Fonseca, J. A., Fontaine, J. F., Forti, S., Fuentes-Perez, J. M., Gálvez-Romero, J. L., Gamkrelidze, A., Garcia-Aymerich, J., García-Cobas, C. Y., Garcia-Cruz, M. H., Gemicioğlu, B., Genova, S., George, C., Gereda, J. E., Gerth van Wijk, R., Gomez, R. M., Gómez-Vera, J., González Diaz, S., Gotua, M., Grisle, I., Guidacci, M., Guldemond, N. A., Gutter, Z., Guzmán, M. A., Haahtela, T., Hajjam, J., Hernández, L., Hourihane, J. O. 'B., Huerta-Villalobos, Y. R., Humbert, M., Iaccarino, G., Illario, M., Ivancevich, J. C., Jares, E. J., Jassem, E., Johnston, S. L., Joos, G., Jung, K. S., Jutel, M., Kaidashev, I., Kalayci, O., Kalyoncu, A. F., Karjalainen, J., Kardas, P., Keil, T., Keith, P. K., Khaitov, M., Khaltaev, N., Kleine-Tebbe, J., Klimek, L., Kowalski, M. L., Kuitunen, M., Kull, I., Kuna, P., Kupczyk, M., Kvedariene, V., Krzych-Fałta, E., Lacwik, P., Larenas-Linnemann, D., Laune, D., Lauri, D., Lavrut, J., Le, L. T. T., Lessa, M., Levato, G., Li, J., Lieberman, P., Lipiec, A., Lipworth, B., Lodrup Carlsen, K. C., Louis, R., Lourenço, O., Luna-Pech, J. A., Maciej, K., Magnan, A., Mahboub, B., Maier, D., Mair, A., Majer, I., Malva, J., Mandajieva, E., Manning, P., De Manuel Keenoy, E., Marshall, G. D., Masjedi, M. R., Maspero, J. F., Mathieu-Dupas, E., Matta Campos, J. J., Matos, A. L., Maurer, M., Mavale-Manuel, S., Mayora, O., Medina-Avalos, M. A., Melén, E., Melo-Gomes, E., Meltzer, E. O., Menditto, E., Mercier, J., Miculinic, N., Mihaltan, F., Milenkovic, B., Moda, G., Mogica-Martinez, M. D., Mohammad, Y., Momas, I., Montefort, S., Monti, R., Mora Bogado, D., Morais-Almeida, M., Morato-Castro, F. F., Mösges, R., Mota-Pinto, A., Moura Santo, P., Mullol, J., Münter, L., Muraro, A., Murray, R., Naclerio, R., Nadif, R., Nalin, M., Napoli, L., Namazova-Baranova, L., Neffen, H., Niedeberger, V., Nekam, K., Neou, A., Nieto, A., Nogueira-Silva, L., Nogues, M., Novellino, E., Nyembue, T. D., O'Hehir, R. E., Odzhakova, C., Ohta, K., Okamoto, Y., Okubo, K., Onorato, G. L., Ortega Cisneros, M., Ouedraogo, S., Pali-Schöll, I., Palkonen, S., Panzner, P., Papadopoulos, N. G., Park, H. S., Papi, A., Passalacqua, G., Paulino, E., Pawankar, R., Pedersen, S., Pépin, J. L., Pereira, A. M., Persico, M., Pfaar, O., Phillips, J., Picard, R., Pigearias, B., Pin, I., Pitsios, C., Plavec, D., Pohl, W., Popov, T. A., Portejoie, F., Potter, P., Pozzi, A. C., Price, D., Prokopakis, E. P., Puy, R., Pugin, B., Pulido Ross, R. E., Przemecka, M., Rabe, K. F., Raciborski, F., Rajabian-Soderlund, R., Reitsma, S., Ribeirinho, I., Rimmer, J., Rivero-Yeverino, D., Rizzo, J. A., Rizzo, M. C., Robalo-Cordeiro, C., Rodenas, F., Rodo, X., Rodriguez Gonzalez, M., Rodriguez-Mañas, L., Rolland, C., Rodrigues Valle, S., Roman Rodriguez, M., Romano, A., Rodriguez-Zagal, E., Rolla, G., Roller-Wirnsberger, R. E., Romano, M., Rosado-Pinto, J., Rosario, N., Rottem, M., Ryan, D., Sagara, H., Salimäki, J., Samolinski, B., Sanchez-Borges, M., Sastre-Dominguez, J., Scadding, G. K., Schunemann, H. J., Scichilone, N., Schmid-Grendelmeier, P., Serpa, F. S., Shamai, S., Sheikh, A., Sierra, M., Simons, F. E. R., Siroux, V., Sisul, J. C., Skrindo, I., Solé, D., Somekh, D., Sondermann, M., Sooronbaev, T., Sova, M., Sorensen, M., Sorlini, M., Spranger, O., Stellato, C., Stelmach, R., Stukas, R., Sunyer, J., Strozek, J., Szylling, A., Tebyriçá, J. N., Thibaudon, M., To, T., Todo-Bom, A., Tomazic, P. V., Toppila-Salmi, S., Trama, U., Triggiani, M., Suppli Ulrik, C., Urrutia-Pereira, M., Valenta, R., Valero, A., Valiulis, A., Valovirta, E., van Eerd, M., van Ganse, E., van Hague, M., Vandenplas, O., Ventura, M. T., Vezzani, G., Vasankari, T., Vatrella, A., Verissimo, M. T., Viart, F., Viegi, M., Vicheva, D., Vontetsianos, T., Wagenmann, M., Walker, S., Wallace, D., Wang, D. Y., Waserman, S., Werfel, T., Westman, M., Wickman, M., Williams, D. M., Williams, S., Wilson, N., Wright, J., Wroczynski, P., Yakovliev, P., Yawn, B. P., Yiallouros, P. K., Yorgancioglu, A., Yusuf, O. M., Zar, H. J., Zhang, L., Zhong, N., Zernotti, M. E., Zidarn, M., Zuberbier, T., Zubrinich, C., Zurkuhlen, A., CHU Montpellier, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Contre les MAladies Chroniques pour un VIeillissement Actif en Languedoc-Roussillon (MACVIA-LR), Université Montpellier 1 (UM1)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Universitaire de Nîmes (CHU Nîmes)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-European Innovation Partnership on Active and Healthy Ageing Reference Site (EIP on AHA), Commission Européenne-Commission Européenne-Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO), Vieillissement et Maladies chroniques : approches épidémiologique et de santé publique (VIMA), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut National de la Santé et de la Recherche Médicale (INSERM), European Forum for Research and Education in Allergy and Airway Diseases (EUFOREA), Catholic University of Leuven - Katholieke Universiteit Leuven (KU Leuven), Laboratory of clinical immunology, Department of Allergy and Clinical Immunology, Transylvania University of Brasov, Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Epidémiologie, Systèmes d'Information, Modélisation, Université Pierre et Marie Curie - Paris 6 (UPMC)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU), Epidemiology of Allergic and Respiratory Diseases Department [iPlesp] (EPAR), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Department of Allergy and Immunology, Hospital Quirónsalud Bizkaia [Bilbao], Center for Research in Environmental Epidemiology (CREAL), Universitat Pompeu Fabra [Barcelona] (UPF)-Catalunya ministerio de salud, Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Hacettepe University = Hacettepe Üniversitesi, Mechanobiology Institute [Singapore] (MBI), National University of Singapore (NUS), Department of Clinical Epidemiology and Biostatistics and Medicine, McMaster University [Hamilton, Ontario], Department of Dermatology [Graz, Austria], Medical University Graz, Swiss Institute of Allergy and Asthma Research (SIAF), Universität Zürich [Zürich] = University of Zurich (UZH), Department Engineering Quimica (ICEMS), Ghent University Hospital, Istituto Nazionale di Fisica Nucleare, sezione di Bari (INFN, sezione di Bari), Istituto Nazionale di Fisica Nucleare (INFN), IMIM-Hospital del Mar, Generalitat de Catalunya, University of Cape Town, Divisions of Human Genetics Infection, Inflammation and Repair, University of Southampton-School of Medicine, Centre de gérontologie, Department of Pathophysiology and Transplantation, Università degli Studi di Milano = University of Milan (UNIMI), Istituto di Geoscienze e Georisorse, Pavia, Institute of Neurobiology and Molecular Medicine, CNR, Rome, Italy and Department of Medicine-University of Naples Federico II = Università degli studi di Napoli Federico II, Woolcock Institute of Medical Research [Sydney], The University of Sydney, Université Laval [Québec] (ULaval), Departments of Clinical Epidemiology and Biostatistics and Medicine [Ontario], Service greffe de moelle osseuse, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Diderot - Paris 7 (UPD7)-Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Département pneumologie et addictologie [Montpellier], Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Hôpital Arnaud de Villeneuve, Royal Brompton Hospital, Région Languedoc-Roussillon-Midi-Pyrénées, Vall d'Hebron University Hospital [Barcelona], University of South Florida [Tampa] (USF), Università degli Studi di Firenze = University of Florence (UniFI), University of Michigan, Department of Atmospheric, Centres de Ressources et de Compétences de la Mucoviscidose [Montpellier] (CRCM [Montpellier]), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Hôpital Arnaud de Villeneuve-Service des Maladies Respiratoires, Russian State Medical University, Universidade do Porto, Instituto de Biologia Molecular e Celular (IBMC), UCB Pharma, Colombes, Hôpital Gui de Chauliac [CHU Montpellier], CHU Strasbourg, European Federation of Allergy (EFA), Airways Diseases Patients' Associations, Università degli Studi di Salerno = University of Salerno (UNISA), Laboratoire de recherche sur les mécanismes moléculaires et pharmacologiques de l’obstruction bronchique (LOBIP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Laboratoire de Génie Informatique et Ingénierie de Production (LGI2P), IMT - MINES ALES (IMT - MINES ALES), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT), Linköping University (LIU), Department of Dermatology and Allergy Centre, Odense University Hospital, Vilnius University [Vilnius], Center of Research in Health Technologies and Information Systems (CINTESIS), Universidade do Porto = University of Porto, Institut d'Electronique du Solide et des Systèmes (InESS), Centre National de la Recherche Scientifique (CNRS), Son Pisa Primary Care Centre, IB-Salut Balearic Health Service, Center for Allergy and Immunology Research [Tbilisi], Department of Dermatology, Helsinki University Hospital-Skin and Allergy Hospital, Swedish Meteorological and Hydrological Institute (SMHI), CORYSS-TESS, Ukrainina Medical Stomatological Academy [Poltava, Ukraine], Institute of Social Medicine, Epidemiology and Health Economics-Charité - UniversitätsMedizin = Charité - University Hospital [Berlin], Biologie des organismes marins et écosystèmes (BOME), Muséum national d'Histoire naturelle (MNHN)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS), NRC Institute of immunology FMBA, Moscow Russian federation, Allergy and Asthma Center Westend, German Society for Otorhinolaryngology HNS, Rheinische Friedrich-Wilhelms-Universität Bonn, The Institute of Environmental Medicine [Stockholm] (IMM), Karolinska Institutet [Stockholm], Medical University of Łódź (MUL), Hospital Medica Sur, Institut de Recherche en Infectiologie de Montpellier (IRIM), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Applied Physical Chemistry Laboratory (APCLab), Institute of Geophysics and Planetary Physics [Los Angeles] (IGPP), University of California [Los Angeles] (UCLA), University of California (UC)-University of California (UC), Équipe de Recherche en Textes, Informatique, Multilinguisme (ERTIM), Institut National des Langues et Civilisations Orientales (Inalco), Institute of Oceanology [China], University of Beira Interior [Portugal] (UBI), Unité de recherche de l'institut du thorax (ITX-lab), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN), Pulmonary and allergy unit, American University of Sharjah-Rashid Hospital-Dubai Health Authority (DHA), Astrophysique Interprétation Modélisation (AIM (UMR7158 / UMR_E_9005 / UM_112)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Sysdiag-Modélisation et Ingénierie des Systèmes Complexes Biologiques pour le Diagnostic (SysDiag ), BIO-RAD-Centre National de la Recherche Scientifique (CNRS), 'Federico II' University of Naples Medical School, Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] (PhyMedExp), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Pneumology Department, Marius Nasta Institute of Pneumology, Department of Prevention of Environmental Hazards and Allergology, Medical University of Warsaw - Poland-Faculté de Pharmacie de Paris, Allergy and Clinical Immunology Department, Hospital CUF Descobertas, Universität zu Köln = University of Cologne, Centro de Investigación Biomédica en Red Enfermedades Respiratorias (CIBERES), Section of Otolaryngology-Head & Neck Surgery (OHNS), University of Chicago, Department of Pharmacy Naples, Université de Naples, Department of Allergy, Immunology and Respiratory Medicine, Alfred Hospital-Monash University Building, AMREP, Dept. of Electronic Engineering, Chubu University, Department of Otorhinolaryngology, Chiba University Hospital, Department of Allergology and Clinical Immunology, Charles University [Prague] (CU)-Medical Faculty in Pilsen, Department of Earth and Planetary Sciences [Cambridge, USA] (EPS), Harvard University, Allergy and Respiratory Diseases, Università degli studi di Genova = University of Genoa (UniGe), Department of Pediatrics, Nippon Medical School, Centre Hospitalier Universitaire [Grenoble] (CHU), Department of Otorhinolaryngology, Head and Neck Surgery [Mannheim, Germany], University Hospital Mannheim, Laboratoire de physique et chimie des nano-objets (LPCNO), Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Institut de Chimie de Toulouse (ICT), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Institut de Recherche sur les Systèmes Atomiques et Moléculaires Complexes (IRSAMC), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), CHU Grenoble, Children’s Hospital Srebrnjak [Zagreb, Croatia], Department of Physics [UMIST Manchester], University of Manchester Institute of Science and Technology (UMIST), Laboratori Nazionali del Sud (LNS), Getafe University Hospital, Madrid, Karl-Franzens-Universität Graz, Ecologie comportementale (EC), École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Recherche Agronomique (INRA)-Université Montpellier 2 - Sciences et Techniques (UM2)-Université Paris-Sud - Paris 11 (UP11)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Université de Rennes (UR)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université de Bourgogne (UB)-Centre National de la Recherche Scientifique (CNRS), Allergy Asthma and Immunology [Haifa, Israel], Ha'Emek Medical Center, Afula-Rappaport Faculty of Medicine, University of Edinburgh, Medical University of Warsaw - Poland, Department of Allergy and Clinical Immunology [Caracas, Venezuela], Centro Médico Docente La Trinidad, Department of Computer Science [Haifa], University of Haifa [Haifa], Allergy and Respiratory Research Group, Institut d'oncologie/développement Albert Bonniot de Grenoble (INSERM U823), Université Joseph Fourier - Grenoble 1 (UJF)-CHU Grenoble-EFS-Institut National de la Santé et de la Recherche Médicale (INSERM), National Centre of Cardiology and Internal Medicine, Ministry of Health Kyrgyz Republic, Réseau National de Surveillance Aérobiologique (RNSA), Berkeley Seismological Laboratory, Division of Clinical Immunology and Allergy, University of Naples Federico II = Università degli studi di Napoli Federico II, CIRCE, Ctr Res Energy Resources & Consumpt, Zaragoza 50018, Spain, Vilnius University Clinic of Children's Diseases, Suomen Terveystalo Allergy Clinic, Health Service and Performance Research (HESPER), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon, Centre d'EPistémologie et d'ERgologie Comparatives (CEPERC), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Institute for Climate and Atmospheric Science [Leeds] (ICAS), School of Earth and Environment [Leeds] (SEE), University of Leeds-University of Leeds, Nova Southeastern University (NSU), Department of Otolaryngology, National University of Singapore (NUS)-Yong Loo Lin School of Medicine, Sachs' Children's Hospital, IAES, Department of Pulmonology, Manisa Celal Bayar University, Center for Evolutionary and Theoretical Immunology [Albuquerque, New Mexico] (CETI), The University of New Mexico [Albuquerque], National Key State Laboratory for ThermoStructural Composites (TSCM), Northwestern Polytechnical University [Xi'an] (NPU), Respiratory and Allergic Diseases, University Clinic of Respiratory and Allergic Diseases Golnik, University Hospital of Cologne [Cologne], Supported by the European Innovation Partnership on Active and Healthy Ageing and POLLAR (EIT Health, European Union)., European Project: 643803,H2020,H2020-HCO-2014,PROEIPAHA(2015), UCL - (MGD) Service de pneumologie, UCL - SSS/IREC/PNEU - Pôle de Pneumologie, ORL et Dermatologie, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Université Montpellier 1 (UM1)-Centre Hospitalier Universitaire de Nîmes (CHU Nîmes)-European Innovation Partnership on Active and Healthy Ageing Reference Site (EIP on AHA), Commission Européenne-Commission Européenne-Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Sorbonne Université (SU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Epidemiology of Allergic and Respiratory Diseases Department [Paris] (EPAR), Sorbonne Université (SU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Hospital Quiròn Bizkaia Erandio, Université Pierre et Marie Curie - Paris 6 (UPMC), University of Milan, University of Naples Federico II-CNR, Rome, Italy and Department of Medicine, Université Paris Diderot - Paris 7 (UPD7)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris], Università degli Studi di Firenze = University of Florence [Firenze] (UNIFI), Hôpital Gui de Chauliac, Université Montpellier 1 (UM1)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Università degli Studi di Salerno (UNISA), Institut de Physique du Globe de Paris (IPGP), Centre National de la Recherche Scientifique (CNRS)-Université de La Réunion (UR)-Université Paris Diderot - Paris 7 (UPD7)-IPG PARIS-Institut national des sciences de l'Univers (INSU - CNRS), Charité - UniversitätsMedizin = Charité - University Hospital [Berlin]-Epidemiology and Health Economics, Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Muséum national d'Histoire naturelle (MNHN), University of California-University of California, unité de recherche de l'institut du thorax UMR1087 UMR6291 (ITX), Astrophysique Interprétation Modélisation (AIM (UMR_7158 / UMR_E_9005 / UM_112)), Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7), Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Hospital CUF-Descobertas, Universität zu Köln, Medical Faculty in Pilsen-Charles University in Prague - the First Faculty of Medicine, Harvard University [Cambridge], University of Genoa (UNIGE), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut de Chimie de Toulouse (ICT-FR 2599), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Institut de Chimie du CNRS (INC)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Institut de Chimie du CNRS (INC)-Institut de Recherche sur les Systèmes Atomiques et Moléculaires Complexes (IRSAMC), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS), University of Graz, École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Recherche Agronomique (INRA)-Université Montpellier 2 - Sciences et Techniques (UM2)-Université Paris-Sud - Paris 11 (UP11)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Université Claude Bernard Lyon 1 (UCBL), Centro Medico-Docente La Trinidad, Institut National de la Santé et de la Recherche Médicale (INSERM)-EFS-CHU Grenoble-Université Joseph Fourier - Grenoble 1 (UJF), Università degli studi di Napoli Federico II, Center for Evolutionary and theoretical Immunology, Biology, National Institute for Health Research, CNR, Rome, Italy and Department of Medicine-University of Naples Federico II, Institut national des sciences de l'Univers (INSU - CNRS)-IPG PARIS-Université Paris Diderot - Paris 7 (UPD7)-Université de La Réunion (UR)-Centre National de la Recherche Scientifique (CNRS), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Institut de Recherche sur les Systèmes Atomiques et Moléculaires Complexes (IRSAMC), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), Karl-Franzens-Universität [Graz, Autriche], Department of Dermatology, Allergology and Venereology, Clinicum, University of Helsinki, Children's Hospital, Faculty of Law, HUS Children and Adolescents, HUS Inflammation Center, University Hospitals Leuven [Leuven], Universitat Pompeu Fabra [Barcelona]-Catalunya ministerio de salud, University of Zürich [Zürich] (UZH), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), University of South Florida (USF), Università degli Studi di Firenze = University of Florence [Firenze], Laboratoire Magmas et Volcans (LMV), Observatoire de Physique du Globe de Clermont-Ferrand (OPGC), Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Jean Monnet [Saint-Étienne] (UJM)-Centre National de la Recherche Scientifique (CNRS), Universidade do Porto [Porto], Charité - Universitätsmedizin Berlin / Charite - University Medicine Berlin -Epidemiology and Health Economics, Université Pierre et Marie Curie - Paris 6 (UPMC)-Muséum national d'Histoire naturelle (MNHN)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM), Centre de Biologie pour la Gestion des Populations (UMR CBGP), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut National de la Recherche Agronomique (INRA)-Centre international d'études supérieures en sciences agronomiques (Montpellier SupAgro)-Université de Montpellier (UM)-Institut de Recherche pour le Développement (IRD [France-Sud])-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro), Sondra, CentraleSupélec, Université Paris-Saclay (COmUE) (SONDRA), ONERA-CentraleSupélec-Université Paris Saclay (COmUE), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche sur les Systèmes Atomiques et Moléculaires Complexes (IRSAMC), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Toulouse III - Paul Sabatier (UT3), RNSA, Centre d'EPistémologie et d'ERgologie Comparatives - UMR 7304 (CEPERC), Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU), Ear, Nose and Throat, AII - Inflammatory diseases, Pulmonology, Institut de Recherche sur les Systèmes Atomiques et Moléculaires Complexes (IRSAMC), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut de Chimie de Toulouse (ICT-FR 2599), Université Fédérale Toulouse Midi-Pyrénées-Institut de Recherche pour le Développement (IRD)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées, Université Montpellier 1 (UM1)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Régional Universitaire de Nîmes (CHRU Nîmes)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-European Innovation Partnership on Active and Healthy Ageing Reference Site (EIP on AHA), National Institute for Nuclear Physics (INFN), Université Laval, Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Université Paris Diderot - Paris 7 (UPD7)-Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (APHP), Università degli Studi di Firenze [Firenze], University of Salerno (UNISA), Centre National de la Recherche Scientifique (CNRS)-Université Jean Monnet [Saint-Étienne] (UJM)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Observatoire de Physique du Globe de Clermont-Ferrand (OPGC), Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Centre National de la Recherche Scientifique (CNRS), Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS), Sondra, CentraleSupélec, Université Paris-Saclay (SONDRA), ONERA-CentraleSupélec-Université Paris-Saclay, Centre National de la Recherche Scientifique (CNRS)-Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), École normale supérieure - Paris (ENS Paris)-Institut National de la Recherche Agronomique (INRA)-Université Montpellier 2 - Sciences et Techniques (UM2)-Université Paris-Sud - Paris 11 (UP11)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Université de Rennes 1 (UR1), Universidade do Minho, İÜC, Cerrahpaşa Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, uBibliorum, and Internal Medicine
Subjects: Allergy, Medicina Básica [Ciências Médicas], asthma -- guideline, Allergic asthma, DECISION-MAKING, Allergic Rhinitis and Its Impact on Asthma, GUIDELINES, Medical and Health Sciences, Medical Records, 0302 clinical medicine, Health care, Immunology and Allergy, 030212 general & internal medicine, asthma, Change management, rhinitis, Immunology, MASK-RHINITIS, ComputingMilieux_MISCELLANEOUS, Rinitis, mobilne aplikacije, upravljanje sprememb, Medical record, GLOBAL STRATEGY, WORK PRODUCTIVITY, Telemedicine, mobile applications, 3. Good health, Asma alérgica, rhiniti, 1107 Immunology, Ciências Médicas::Medicina Básica, klinične poti, allergic -- guideline, Life Sciences & Biomedicine, Human, PATIENT PARTICIPATION, Allergic Rhinitis, medicine.medical_specialty, animal structures, multimorbidity, EUROPEAN INNOVATION PARTNERSHIP, Change Management, [object Object], Settore MED/10 - Malattie Dell'Apparato Respiratorio, Asthma/diagnosis, CHRONIC DISEASES, MACVIA-ARIA, 03 medical and health sciences, medicine, multimorbidnost, QUALITY, Humans, critical pathways, astma -- smernica, Patient participation, Asma, udc:616.2, Asthma, Science & Technology, ARIA, business.industry, Multimorbidity, Rhinitis, Allergic, Settore MED/09 - MEDICINA INTERNA, change management, Mobile Airways Sentinel Network (MASK) Study Group, Guideline, ta3121, medicine.disease, Rinite alérgica, Rhinitis, Allergic/diagnosis, Integrated care, alergijski rinitis -- smernica, Allergic Rhinitis and Its Impact on Asthma, asthma, Change management, rhinitis, Immunology and Allergy, Immunology, 030228 respiratory system, Family medicine, 3121 General medicine, internal medicine and other clinical medicine, Medical Record, Clinical Medicine, business, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, Impact on Asthma
Abstract: Allergic Rhinitis and its Impact on Asthma (ARIA) has evolved from a guideline by using the best approach to integrated care pathways using mobile technology in patients with allergic rhinitis (AR) and asthma multimorbidity. The proposed next phase of ARIA is change management, with the aim of providing an active and healthy life to patients with rhinitis and to those with asthma multimorbidity across the lifecycle irrespective of their sex or socioeconomic status to reduce health and social inequities incurred by the disease. ARIA has followed the 8-step model of Kotter to assess and implement the effect of rhinitis on asthma multimorbidity and to propose multimorbid guidelines. A second change management strategy is proposed by ARIA Phase 4 to increase self-medication and shared decision making in rhinitis and asthma multimorbidity. An innovation of ARIA has been the development and validation of information technology evidence-based tools (Mobile Airways Sentinel Network [MASK]) that can inform patient decisions on the basis of a self-care plan proposed by the health care professional., EAACI -European Academy of Allergy and Clinical Immunology(undefined), info:eu-repo/semantics/acceptedVersion
Published: 2018
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14. De novo Atypical Chromosome Translocation 46, XY, t(4;13)(q12;p12)dn in Prenatal Diagnosis

Author: M, Chetta, primary, L, Di-Matteo, additional, M, Russo, additional, E, Sodano, additional, M, Festa, additional, and G, De-Feo, additional
Published: 2018
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15. A comparison of the efficacy of organic and mixed-organic polymers with polyaluminium chloride in chemically assisted primary sedimentation (CAPS)

Author: M Galasso, G. De Feo, R. Landi, A. Donnarumma, and S. De Gisi
Subjects: Flocculation, Multi-criteria analysis, Polymers, Sedimentation (water treatment), Polyaluminium chloride, Aluminum Hydroxide, Chemical Fractionation, Waste Disposal, Fluid, Water Purification, CAPS, Organic polymers, Urban wastewater, Nephelometry and Turbidimetry, Sewage, Environmental Chemistry, Waste Management and Disposal, Water Science and Technology, Coagulation (water treatment), chemistry.chemical_classification, Primary (chemistry), Waste management, Waste Disposal, General Medicine, Polymer, Anaerobic digestion, chemistry, Wastewater, Sewage treatment, Fluid
Abstract: CAPS is the acronym for chemically assisted primary sedimentation, which consists of adding chemicals to raw urban wastewater to increase the efficacy of coagulation, flocculation and sedimentation. The principal benefits of CAPS are: upgrading of urban wastewater treatment plants; increasing efficacy of primary sedimentation; and the major production of energy from the anaerobic digestion of primary sludge. Metal coagulants are usually used because they are both effective and cheap, but they can cause damage to the biological processes of anaerobic digestion. Generally, biodegradable compounds do not have these drawbacks, but they are comparatively more expensive. Both metal coagulants and biodegradable compounds have preferential and penalizing properties in terms of CAPS application. The problem can be solved by means of a multi-criteria analysis. For this purpose, a series of tests was performed in order to compare the efficacy of several organic and mixed-organic polymers with that of polyaluminium chloride (PACl) under specific conditions. The multi-criteria analysis was carried out coupling the simple additive weighting method with the paired comparison technique as a tool to evaluate the criteria priorities. Five criteria with the following priorities were used: chemical oxygen demand (COD) removalturbidity, SV60coagulant dose, and coagulant cost. The PACl was the best alternative in 70% of the cases. The CAPS process using PACl made it possible to obtain an average COD removal of 68% compared with 38% obtained, on average, with natural sedimentation and 61% obtained, on average, with the best PACl alternatives (cationic polyacrylamide, natural cationic polymer, dicyandiamide resin).
Published: 2013
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16. Water and wastewater management in the treatment process of a Roman fullonica

Author: S. De Gisi and G. De Feo
Subjects: Waste management, Fullery, Treatment process, Water, Reuse, Wastewater, Fullonica, Pompeii, Water Science and Technology, Mining engineering, Chemical agents, Environmental science
Abstract: The aim of this paper is to study the treatment process of a Roman fullery (fullonica) with particular attention to the water and wastewater management system. Remains of several fullonicae have been documented at Pompeii and Herculaneum (Campania, Southern Italy), Ostia and Rome (Latium region, Central Italy), Florence (Tuscany, Central Italy), etc. The common academic perception of Roman fullonicae is significantly influenced by the fullonica of Stephanus (I 6, 7) in Pompeii, which is assumed to be a paradigmatic case study in this paper. The use of urine as an alkaline chemical agent in the soaping phase of the filling treatment process was overstated, with there also being no evidence of the fact that fullers collected their urine by means of vessels in front of their workshops, as usually reported. Thus, it is not clear how the Roman fullers collected and transported the urine they used in the fulleries. Finally, the rinsing phase can be considered a clear example of water reuse.
Published: 2013
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17. Investigation of the environmental impacts of municipal wastewater treatment plants through a Life Cycle Assessment software tool

Author: G. De Feo and Carmen Ferrara
Subjects: Engineering, 020209 energy, Software tool, 02 engineering and technology, 010501 environmental sciences, Environment, Wastewater, 01 natural sciences, Waste Disposal, Fluid, Sewerage, 0202 electrical engineering, electronic engineering, information engineering, Per capita, Environmental Chemistry, Environmental impacts, LCA, sewerage, wastewater, WWTP, Waste Management and Disposal, Life-cycle assessment, 0105 earth and related environmental sciences, Water Science and Technology, Waste management, business.industry, General Medicine, Environmental economics, Sewage treatment, Population equivalent, business, Software
Abstract: This paper investigates the total and per capita environmental impacts of municipal wastewater treatment in the function of the population equivalent (PE) with a Life Cycle Assessment (LCA) approach using the processes of the Ecoinvent 2.2 database available in the software tool SimaPro v.7.3. Besides the wastewater treatment plant (WWTP), the study also considers the sewerage system. The obtained results confirm that there is a 'scale factor' for the wastewater collection and treatment even in environmental terms, in addition to the well-known scale factor in terms of management costs. Thus, the more the treatment plant size is, the less the per capita environmental impacts are. However, the Ecoinvent 2.2 database does not contain information about treatment systems with a capacity lower than 30 PE. Nevertheless, worldwide there are many sparsely populated areas, where it is not convenient to realize a unique centralized WWTP. Therefore, it would be very important to conduct an LCA study in order to compare alternative on-site small-scale systems with treatment capacity of few PE.
Published: 2016

18. Life cycle assessment and economic analysis of a low concentrating photovoltaic system

Author: G. De Feo, Fabio Petito, Carlo Renno, and M. Forni
Subjects: Engineering, 020209 energy, Software tool, Conservation of Energy Resources, 02 engineering and technology, economic analysis, life cycle assessment, 0202 electrical engineering, electronic engineering, information engineering, Environmental Chemistry, Economic analysis, Process engineering, Waste Management and Disposal, Life-cycle assessment, Water Science and Technology, Carbon Footprint, Ecological footprint, Ecology, business.industry, LCA, Photovoltaic system, General Medicine, Electrochemical Techniques, 021001 nanoscience & nanotechnology, Photovoltaic, LCPV, Carbon footprint, Electricity, Electric power, 0210 nano-technology, business
Abstract: Many new photovoltaic (PV) applications, such as the concentrating PV (CPV) systems, are appearing on the market. The main characteristic of CPV systems is to concentrate sunlight on a receiver by means of optical devices and to decrease the solar cells area required. A low CPV (LCPV) system allows optimizing the PV effect with high increase of generated electric power as well as decrease of active surface area. In this paper, an economic analysis and a life cycle assessment (LCA) study of a particular LCPV scheme is presented and its environmental impacts are compared with those of a PV traditional system. The LCA study was performed with the software tool SimaPro 8.0.2, using the Econinvent 3.1 database. A functional unit of 1 kWh of electricity produced was chosen. Carbon Footprint, Ecological Footprint and ReCiPe 2008 were the methods used to assess the environmental impacts of the LCPV plant compared with a corresponding traditional system. All the methods demonstrated the environmental convenience of the LCPV system. The innovative system allowed saving 16.9% of CO2 equivalent in comparison with the traditional PV plant. The environmental impacts saving was 17% in terms of Ecological Footprint, and, finally, 15.8% with the ReCiPe method.
Published: 2016

19. Technical, economic and environmental analysis of a MSW kerbside separate collection system applied to small communities

Author: G. De Feo and C Malvano
Subjects: Sustainable development, Environmental analysis, Population, Paired comparison, Environment, Collection system, Discount points, Agricultural economics, Motor Vehicles, Geography, Waste Management, Environmental protection, Per capita, Humans, Recycling, Environmental impact assessment, Waste Management and Disposal, Life-cycle assessment
Abstract: The main aim of this study was to evaluate the costs and environmental impacts induced by a fixed model of MSW kerbside separate collection system for communities up to 10,000 inhabitants, in order to evaluate the convenience for the smaller municipalities to unite and form more economically and environmentally sound systems. This topic is important not only due to the large number of small municipalities (e.g. in Italy 72% of the municipalities has less than 5000 inhabitants) but also to the fact that separate collection systems are typically designed to take into account only the technical and economic aspects, which is a practice but not acceptable in the light of the sustainable development paradigm. In economic terms, between 1000 and 4000 inhabitants, the annual per capita cost for vehicles and personnel decreased, with a maximum at approximately 180 €/inhabitants/year; while, from 5000 up to 10,000 inhabitants, the annual per capita cost was practically constant and equal to about 80 €/inhabitants/year. For the municipalities of less than 5000 inhabitants, from an economic point of view the aggregation is always advantageous. The environmental impacts were calculated by means of the Life Cycle Assessment tool SimaPro 7.1, while the economic-environmental convenience was evaluated by combining in a simple multicriteria analysis, the annual total per capita cost (€/inhabitants/year) and the annual total per capita environmental impact (kEco-indicator point/inhabitants/year), giving the same importance to each criteria. The analysis was performed by means of the Paired Comparison Technique using the Simple Additive Weighting method. The economic and environmental convenience of the aggregation diminishes with the size of the municipalities: for less than 4000 inhabitants, the aggregation was almost always advantageous (91.7%); while, for more than or equal to 5000 inhabitants, the aggregation was convenient only in 33.3% of the cases. On the whole, out of 45 cases examined, for the municipalities from 1000 to 9000 inhabitants, the aggregation was both economically and environmentally convenient in 60.0% of the cases.
Published: 2012
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20. Historical, biological and morphological aspects of the Roccarainola qanat in the district of Naples, Italy

Author: F. Maurano, M. Manco, E. Tropeano, G. De Feo, Domenico Capolongo, S Del Prete, C Malvano, and S. De Gisi
Subjects: geography, geography.geographical_feature_category, Ecology, Qanat, biological, drainage tunnel, historical, morphological, qanat, Roccarainola, morphological, Present day, Biology, historical, Archaeology, Debris, Biological, Drainage tunnel, Historical, Morphological, Roccarainola, Water Science and Technology, Circular section, drainage tunnel, qanat, Animal species, biological, Channel (geography), Stratum, Open air
Abstract: A qanat is an underground channel consisting of verticals shafts connected at their bottom with a sub-horizontal tunnel bringing water from an aquiferous stratum, with a slight downward slope useful for the water tapped to run down it and into the open air by gravity. Qanats were first developed in Kurdistan as a side result of mining activity by the early millennium B.C. at the latest. Qanats exist in more than 34 countries all over the world, but most are concentrated in present day Iran. In Italy, Sicily is usually cited for its “Ingruttati”, but also in the Campania Region, there are some qanats (“Qanate”). As a matter of fact, this paper describes the historical, biological and morphological aspects of the Roccarainola qanat located in the district of Naples, in Southern Italy. It dates back to the Roman Ages, but currently the hypogean environmental condition misrepresents its ancient state. The animal species discovered forty years ago in the Roccarainola qanat were substantially small sized arthropods, a planaria and some species of bats. The Roccarainola qanat is composed of three branches for a total length of 786 m, with a drop of 9 m. The tunnel slope varies from around 1.70 cm/m to 5.20 cm/m. However, original slopes have been modified due to accumulation of debris and waste. Seventeen vertical shafts (not internally covered) with a circular section were found along the hypogeum. On the average, the shafts are spaced 36.5 m apart.
Published: 2010
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21. The greatest water reservoirs in the ancient Roman world and the 'Piscina Mirabilis' in Misenum

Author: O. De Biase, C Malvano, G. De Feo, and S. De Gisi
Subjects: Miseno, education.field_of_study, Piscina Mirabilis, business.industry, Roman aqueduct, Population, Environmental engineering, Water supply, Aqueduct, Serino, Piscina, Archaeology, Geography, Naples, Water Science and Technology, education, business, Miseno, Naples, Piscina Mirabilis, Roman aqueduct, Serino
Abstract: The aim of the present study was to investigate the greatest water reservoirs in the ancient Roman world and, in particular, the “Piscina Mirabilis” in Misenum, in Southern Italy. In our study, we considered the reservoirs with a volume in the order of thousands of cubic metres, storing flowing water, set low in the ground or actually underground, and roofed over. In general, a Roman aqueduct was not built to provide drinking water, nor to promote hygiene, but either to supply the baths or for military aims. As a matter of fact, the population of Rome at the end of the 1st century AD had an average water supply of 1,550 L/d per capita especially used for baths. This circumstance required reservoirs of huge capacity. The reservoir of the Baths of Caracalla in Rome could contain over 80,000 m3 of water. The use of columns in a Roman reservoir was introduced in the ancient Constantinopolis and the Yerebatan Saray with a maximum capacity of almost 85,000 cubic metres can be considered the biggest Roman reservoir. While for military aims, the Piscina Mirabilis in Misenum can be considered the biggest Roman resevoirs used for military aims ever known until now (provide the Classis Praetoria Misenensis) with a volumetric capacity of 12,600 m3 of water.
Published: 2010
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22. Water and wastewater management technologies through the centuries

Author: G. De Feo, P. Laureano, R. Drusiani, and Andreas N. Angelakis
Subjects: cisterns, Irrigation, Engineering, business.industry, ancient civilizations, Environmental engineering, Water supply, Sewage, Aqueduct, reservoirs, ancient civilizations, aqueducts, cisterns, drainage, fountains, irrigation, qanats, reservoirs, sewerage, toilets, fountains, irrigation, Wastewater, sewerage, toilets, Sustainability, Sewerage, aqueducts, Drainage, business, Environmental planning, drainage, qanats, Water Science and Technology
Abstract: The aim of this paper is to propose a journey through the history of water and wastewater management technologies in the ancient civilizations, a sort of Appian Way (“Via Appia”, the “regina longarum viarum”) through the Centuries. Moreover, this paper is a sort of short summary of papers presented in the first two IWA Specialty Conferences on Water and Wastewater Technologies in Ancient Civilizations with particular emphasis on the later one. The main topics considered are: aqueducts and tunnels, cisterns and reservoirs, water distributions systems, fountains, toilets and other purgatory structures, drainage and sewerage systems, irrigation systems and, finally, qanats and other similar systems. Upon completing the journey, we have arrived at the conclusion that the meaning of sustainability in modern times should be revaluated in light of ancient hydraulic water and wastewater works and management practices.
Published: 2010
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23. Definition of a multi-criteria, web-based, approach to managing the illegal dumping of solid waste in Italian villages

Author: F. Cerrato, G. De Feo, P. Siano, and Vincenzo Torretta
Subjects: Conservation of Natural Resources, Engineering, Municipal solid waste, Geographic information system, Databases, Factual, dumpsite, web-based, Illegal dumping, Online Systems, illegal dumping, multi-criteria analysis, solid waste, Environmental Chemistry, Web application, Waste Management and Disposal, Water Science and Technology, Internet, Waste management, Information Dissemination, dumpsite, illegal dumping, multi-criteria analysis, solid waste, web-based, business.industry, Social cost, General Medicine, Environmental economics, Refuse Disposal, Shared resource, Waste Disposal Facilities, Intervention (law), Italy, Ranking, Geographic Information Systems, Crime, business, Environmental Monitoring
Abstract: The aim of this study is to define a multi-criteria, web-based approach that can be used to manage the illegal dumping of solid waste, which is a serious environmental concern both in developing and developed countries. A simplified web-based geographic information system (SI-WEB-GIS) was designed to identify illegal dumpsites, and to allow sharing resources among authorities, technicians and citizens. A self-made multi-criteria technique was designed to establish the intervention priorities, in seven steps: (1) constructing the alternatives matrix; (2) giving a qualitative value or a combination of qualitative values to each individual dumpsite and to all criteria; (3) giving a numeric value to each qualitative value or combination of qualitative values in the alternatives matrix (three methods were adopted); (4) calculating the Average Hazard Index (AHI); (5) ranking the dumpsites of each alternatives matrix, in the order of decreasing AHI; (6) comparing the first 50% of the dumpsites in the three rankings, in order to evaluate which had the most intervention priorities and (7) performing a sensitivity analysis, giving different priorities to the four criteria adopted (relative quantity of waste, soil permeability level, pollution targets and types of solid waste). The application of the multi-criteria, web-based approach to managing the illegal dumping of solid waste allows minimizing the total social cost of pollution, rehabilitating dumpsites and monitoring illegal dumping. Although the system was applied to a village in Southern Italy, with around 14,000 inhabitants, it can easily be customized for use in similar villages in Italy and in other countries.
Published: 2014

24. 'Privatization in Oligopoly: the impact of the shadow cost of public funds', Working Paper 3.195 dell'Università degli Studi di Salerno

Author: CAPUANO, CARLO, G. DE FEO, Capuano, Carlo, and G., DE FEO
Subjects: Privatizzazioni e liberalizzazioni
Abstract: Si fornisce un contributo originale all'interno della letteratura sulla privatizzazione di imprese pubbliche quale meccanismo interno di regolamentazione di un mercato oligopolistico. Si mette in luce il ruolo che ha nella scelta del manager pubblico del costo dei fondi pubblici.
Published: 2008

25. Mixed Oligopoly, Privatization and the shadow cost of public funds

Author: CAPUANO, CARLO, G. DE FEO, Capuano, Carlo, and G., DE FEO
Subjects: collusion, Mixed oligopoly, endogenous timing
Abstract: The purpose of this paper is to investigate the effect of privatization in a mixed duopoly, where a private firm competes in quantities with a welfare-maximizing public firm. We consider two inefficiencies of the public sector: a possible cost inefficiency, and an allocative inefficiency due to the distortionary effect of taxation (shadow cost of public funds). Furthermore, we analyze the effect of privatization on the timing of competition by endogenizing the determination of simultaneous (Nash-Cournot) versus sequential (Stackelberg) games using the model developed by Hamilton and Slutsky (1990). The latter is especially relevant for the analysis of privatization, given that results and policy prescription emerged in the literature crucially rely on the type of competition assumed. We show that privatization has generally the effect of shifting from Stackelberg to Cournot equilibrium and that, absent efficiency gains privatization never increases welfare. Moreover, even when large efficiency gains are realized, an inefficient public firm may be preferred.
Published: 2008

26. Lacrimal fluid peroxidase activity during the menstrual cycle

Author: G. de Feo, G. Del Bianco, Giordana Marcozzi, Federica Madia, and Eleonora Mattei
Subjects: medicine.medical_specialty, Saliva, biology, Chemistry, media_common.quotation_subject, Urine, Luteal phase, Sensory Systems, Cellular and Molecular Neuroscience, Ophthalmology, Endocrinology, Internal medicine, medicine, biology.protein, Tears, Ovulation, Menstrual cycle, Morning, Peroxidase, media_common
Abstract: Purpose. The aim of this work was to investigate peroxidase activity in human tears during the various phases of the menstrual cycle. For comparative purposes saliva was also examined. Methods. Tear fluids and saliva from 10 healthy volunteers 23–41 years of age (mean: 28.2 years), with regular menstrual cycles were sampled for the duration of at least two complete cycles. Menstrual cycles and ovulation periods were evaluated by measuring morning body temperature and hormone levels in plasma and urine. Unstimulated tears and unstimulated saliva were collected in the morning every two days. Peroxidase activity was monitored according to the 5,5'-dithiobis,2-nitrobenzoic acid thiocyanate (Nbs-SCN) method and the protein content was determined by the Bradford method. Results. Peroxidase activity in tears, expressed as U/mL, was significantly (p
Published: 2000
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27. Rescue of traumatized riders in world circuits: a comparison between skidboard vs scoop Exl65 and aluminium scoop stretchers

Author: Enrico, Farabegoli, Alessandro, Bellati, Marco, Forestan, Massimo, Berardi, G, De Feo, and Eraldo, Berardi
Subjects: Stretchers, Humans, Aluminum
Abstract: We compared the following stretchers to identify the better and safer to immobilize a fallen rider on the track. The stretchers were: Northwall's Innovation Skidboard, Ferno's Scoop EXL65 and anonymous aluminium scoop stretcher. We performed tests on track with several repetitions on a 25 meters path including asphalt, curb, natural and synthetic grass, and gravel. The Dainese Company supplied a suit and a helmet with sensors equipped to receive data. Dainese engineers processed data too. We timed the performance made by teams of three operators, men and women in different roles. The Skidboard turned out to be the most innovative and secure spine board, because generates less energy than other stretchers and reduces, almost cancels, the harmful consequences of the patient's fall on the ground. Exl65 generates more spin and longitudinal stresses than Skidboard, especially the cervical spine. Skidboard is faster than other stretchers to complete the fallen rider's rescue on the track. It is the only spineboard that allows to tie the patient to the stretchers from head to toe, which does not happen with the aluminum scoop and only partially with the Exl65. Skidboard is better than others to rescue fallen and traumatized riders on the tracks quickly and safely.
Published: 2013

28. A simple method to equalize the workload when operating several small wastewater treatment plants: A case study

Author: G. De Feo, S. De Gisi, and M Galasso
Subjects: Engineering, Service (systems architecture), Personnel, population equivalent, small plants, wastewater, workload, Ecology, Environmental Restoration and Remediation, Humans, Italy, Waste Disposal, Fluid, Waste Water, Water Purification, Workload, Environmental Chemistry, Waste Management and Disposal, Water Science and Technology, Operations management, Simulation, SIMPLE (military communications protocol), business.industry, Waste Disposal, General Medicine, Work (electrical), Wastewater, Order (business), Workforce, Sewage treatment, Population equivalent, Fluid, business
Abstract: The aim of the present study is to define a simple (and easy to use) method to equalize the workload of personnel operating several small wastewater treatment plants (SWWTPs). The approach is illustrated through a case study which is the result of collaboration between researchers and a water and wastewater management company operating in Southern Italy. The topic is important since personnel have a significant impact on the operating costs of SWWTPs, and the approach outlined results in the minimum number of staff being required to assure the management of the service. Four kinds of work units are considered: plant managers, assistant plant managers, laboratory technicians and executives. In order to develop a practical, feasible and easy to use method, the workload was evaluated considering only the population equivalent (PE) and the number of plants managed. The core of the method is the evaluation of the percentage of time that the personnel units devote to the operation of SWWTPs of the municipality considered. The proposed procedure offers a useful tool to equalize the workload, both in terms of PE and the number of plants managed, the procedure being easily modifiable to introduce other evaluation criteria. By using familiar concepts such as PE and number of plants managed, the approach of the method can easily be understood by management. It can also be readily adapted to other similar situations.
Published: 2013

29. What lessons can be learnt from studying a Roman hydraulic structure in a little village in Southern Italy?

Author: S. Abbondandolo, G. De Feo, S. De Gisi, and Federica Ribera
Subjects: Engineering, business.industry, media_common.quotation_subject, Water supply, Cisterns, Fountains, Galleries, Roman, Sustainability, Civil engineering, Critical infrastructure, Hydraulic structure, Order (exchange), Service (economics), Urbanization, Water Science and Technology, business, Fountain, Environmental planning, media_common
Abstract: The aim of this paper is to study a Roman hydraulic structure in a little village in Southern Italy in order to learn some lessons from the past and identify potential ideas for implementation. Despite increasing global urbanization a significant percentage of people inhabiting inland areas need critical infrastructure service including water supply systems. The fountain system under consideration in this paper is a good example of a sustainable use of the local territory, which is desirable for modern development of infrastructure. In terms of capital investment and management costs, it is better to try and solve supply issues locally in inland areas rather than to construct mega hydraulic works. During the late Roman Republic, some small inland villagers were obliged to think as well as to act locally. The Roman system investigated here highlights the use of local building elements (and traditional construction techniques) in a sort of ‘zero kilometre’ philosophy.
Published: 2012

30. Bone effect of adjuvant tamoxifen, letrozole or letrozole plus zoledronic acid in early-stage breast cancer: the randomized phase 3 HOBOE study

Author: G. Buonfanti, Ciro Gallo, A. De Matteis, Simona Signoriello, Vincenza Tinessa, Alessandro Morabito, F. Perrone, Mauro Piccirillo, Carmen Pacilio, Gennaro Daniele, E. De Maio, M. De Laurentiis, Roberta D’Aniello, G. Botti, Giuseppe Esposito, F. Di Rella, G. Landi, Elisa Rossi, Massimiliano D’Aiuto, M. Di Bonito, Nicola Normanno, G. De Feo, A. Bartiromo, G. Colantuoni, Secondo Lastoria, Piera Maiolino, M. Di Maio, V. Labonia, Pasqualina Giordano, Adriano Gravina, Francesco Nuzzo, Nuzzo, F, Gallo, C, Lastoria, S, Di Maio, M, Piccirillo, Mc, Gravina, A, Landi, G, Rossi, E, Pacilio, C, Labonia, V, Di Rella, F, Bartiromo, A, Buonfanti, G, De Feo, G, Esposito, G, D'Aniello, R, Maiolino, Paola, Signoriello, S, De Maio, E, Tinessa, V, Colantuoni, G, DE LAURENTIIS, Michelino, D'Aiuto, M, Di Bonito, M, Botti, G, Giordano, P, Daniele, G, Morabito, A, Normanno, N, de Matteis, A, Perrone, F., Gallo, Ciro, Maiolino, P, Signoriello, Simona, and De Laurentiis, M
Subjects: Oncology, Adult, medicine.medical_specialty, medicine.medical_treatment, Breast Neoplasms, Zoledronic Acid, law.invention, Breast cancer, Randomized controlled trial, law, Bone Density, Internal medicine, Antineoplastic Combined Chemotherapy Protocols, Nitriles, medicine, Humans, Aged, Neoplasm Staging, Bone mineral, Aged, 80 and over, Chemotherapy, Bone Density Conservation Agents, Diphosphonates, Estradiol, business.industry, Letrozole, Imidazoles, Hematology, Middle Aged, Triazoles, medicine.disease, Triptorelin, Tamoxifen, Zoledronic acid, Chemotherapy, Adjuvant, Female, business, medicine.drug
Abstract: BACKGROUND To measure bone mineral density (BMD) reduction produced by letrozole as compared with tamoxifen and the benefit of the addition of zoledronic acid. PATIENTS AND METHODS A phase 3 trial comparing tamoxifen, letrozole or letrozole+zoledronic acid in patients with hormone receptor-positive early breast cancer was conducted; triptorelin was given to premenopausal patients. Two comparisons were planned: letrozole versus tamoxifen and letrozole+zoledronic acid versus letrozole. Primary end point was the difference in 1-year change of T-score at lumbar spine (LTS) measured by dual energy X-ray absorptiometry scan. RESULTS Out of 483 patients enrolled, 459 were available for primary analyses. Median age was 50 (range 28-80). The estimated mean difference (95% confidence interval [CI]) in 1-year change of LTS was equal to -0.30 (95% CI -0.44 to -0.17) in the letrozole versus tamoxifen comparison (P
Published: 2012

31. Water and Wastewater Management Technologies in the Ancient Greek and Roman Civilizations

Author: Andreas N. Angelakis, G. De Feo, and Larry W. Mays
Subjects: Minoans, Sustainable development, Ancient civilizations, Cistern, Aqueducts, Cisterns, Drainage, Fountains, Greek, Reservoirs, Romans, Toilets, Sewerage, Aqueduct, Ancient Greek, Archaeology, language.human_language, Rainwater harvesting, Geography, Wastewater, language, Minoan civilization
Abstract: This chapter presents an overview of water and wastewater management practices in the ancient Minoan, Greek, and Roman civilizations. The main topics considered are: aqueducts; cisterns and reservoirs; water distribution systems and fountains; and drainage, sewerage systems, and toilets. The ancient technologies were surprisingly modern. The Minoan civilization gave an extraordinary contribution to the development of water and wastewater management practices. Also, most Greek houses had a cistern supplied by rainwater for several purposes (bathing, cleaning, houseplants, domestic animals, etc.) according to the sustainable development paradigm. The construction of an ancient Roman aqueduct was similar in principle to the present day.
Published: 2011
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32. Analisi non lineare di gusci sottili

Author: G. DE FEO, A. GESUALDO, MINUTOLO, Vincenzo, RUOCCO, Eugenio, G., DE FEO, A., Gesualdo, Minutolo, Vincenzo, and Ruocco, Eugenio
Published: 1999

33. Groundwater recharge in an endoreic basin with reclaimed municipal wastewater

Author: G. De Feo, Vincenzo Belgiorno, and M Galasso
Subjects: Conservation of Natural Resources, Environmental Engineering, Water table, Aquifer, Waste Disposal, Fluid, Water Purification, endoreic basin, nitrate, Water Supply, Groundwater pollution, Groundwater discharge, swallow hole, Water Science and Technology, Hydrology, geography, geography.geographical_feature_category, Water Pollution, Constructed wetland, endoreic basin, groundwater recharge, nitrate, swallow hole, wastewater reuse, Groundwater recharge, groundwater recharge, wastewater reuse, Constructed wetland, Wastewater, Environmental science, Groundwater, Water Pollutants, Chemical
Abstract: The aim of this paper was to evaluate the groundwater pollution in an endoreic basin in southern Italy. The aquifer circulation was carried out on two different levels: a shallow groundwater, with a water table of about 10 m, and a deep groundwater in a karst aquifer, with a water table of 140–190 m. Reclaimed municipal wastewater and superficial water collected in the catchment area were both drained in a swallow hole linked with the deep groundwater. The agricultural practice conducted in the endoreic basin produced an excess of nitrate in the soil. Nitrate was subsequently washed out and displaced in the groundwater. With regard to the EU Drinking Water Directive (98/83/EC), the research activity conducted during 2003 showed the absence of pollution in the deep groundwater used for drinking water supply. The shallow groundwater, instead, was strongly influenced by agricultural and pasture activities, with detectable levels of nitrates and bacteria. In order to reduce the load of pollution entering the swallow hole and then in the deep groundwater, the realisation of a constructed wetland plant was proposed to improve the quality of reclaimed wastewater, as well as to pursue the wastewater reuse in agriculture.
Published: 2007

34. [Bronchiectasis, pulmonary abcess and clubbing]

Author: Alejandro R, Grinberg, Lucas G de, Feo, and Ricardo H, Re
Subjects: Adult, Osteoarthropathy, Secondary Hypertrophic, Humans, Female, Lung Abscess, Tomography, X-Ray Computed, Bronchiectasis
Published: 2006

35. Historical development of the Augustan aqueduct in Southern Italy: twenty centuries of works from Serino to Naples

Author: G. De Feo and R.M.A Napoli
Subjects: Miseno, Geography, Piscina Mirabilis, Roman aqueduct, Aqueduct, Naples, Ancient history, Main channel, Miseno, Naples, Piscina Mirabilis, Roman aqueduct, Serino, Serino, Water Science and Technology, Roman Empire
Abstract: The aim of the present study was to investigate the historical development of the Augustan Aqueduct Serino-Naples-Miseno in the Campania Region, in Southern Italy. The Serino aqueduct is not well known because there are no remains of spectacular bridges, but it was a masterpiece of engineering and one of the largest aqueduct systems in the whole Roman Empire. The Serino aqueduct was constructed during the Augustus period of the Roman Empire, probably between 33 and 12 BC when Marcus Vipsanius Agrippa was curator aquarum in Rome, principally in order to refurnish the Roman fleet of Misenum and secondarily to supply water for the increasing demand of the important commercial harbour of Puteoli as well as drinking water for big cities such as Cumae and Neapolis. The main channel of the Serino aqueduct was approximately 96 km long, and had 7 main branches to towns along its trace such as Nola, Pompeii, Acerra, Herculaneum, Atella, Pausillipon, Nisida, Puteoli, Cumae and Baiae. Since the total length of all the branches was approximately 49 km, the Serino aqueduct complex had a length of around 145 km and therefore it should be considered the largest aqueduct system in the Roman world.
Published: 2006

36. Treatment of high strength wastewater with vertical flow constructed wetland filters

Author: G. De Feo, Vincenzo Belgiorno, and Giusy Lofrano
Subjects: Environmental Engineering, high strength wastewater, Nitrogen, Poaceae, Waste Disposal, Fluid, Water Purification, Phragmites, landfill leachate, Dry weight, Tap water, vertical flow, Water Movements, reed beds, Leachate, Kjeldahl method, Ecosystem, Water Science and Technology, Environmental engineering, Phragmites Australis, Constructed wetland, Macrophyte, Biodegradation, Environmental, Wastewater, Seedlings, Environmental science, Constructed wetland, high strength wastewater, landfill leachate, Phragmites australis, reed beds, vertical flow, Filtration
Abstract: The aim of the present study was to evaluate the behaviour of vertical flow constructed wetlands to treat high strength wastewater. Influents were obtained mixing tap water with different percentages of MSW landfill leachate (5%, 10% and 20%). Phragmites australis seedlings were used as macrophytes. The reeds were nurtured during three spring months, before the start of the experimental period. Three and four days of detention time were adopted. Influent concentrations of 510-2,050 mg L(-1), 180-740 mg L(-1) and 65-260 mg L(-1) were obtained for COD, N-NH4(+) and N-NO3(-), respectively. The environmental temperature averaged around 31.0 +/- 1.4 degrees C. During the experimental period, all parameters showed an increasing removal efficiency trend. Best results in terms of COD removal were obtained for mixtures at lowest rate of landfill leachate; while, denitrification process showed an opposite behaviour; finally, the removal of ammonia nitrogen appeared to be independent upon influent concentrations. Analysis carried out on the reed tissues showed a theoretic maximum storage of TKN in the leaves of about 55 mg/g dry weight. A leachate percentage of about 35% was derived to be able to fully inhibit the growth of macrophytes.
Published: 2005

37. Más sobre aorta espículo anfractuosa

Author: Lucas G. De Feo, Juan P. Suarez, and Pablo Landi
Subjects: lcsh:Immunologic diseases. Allergy, lcsh:R, lcsh:Medicine, lcsh:RC109-216, lcsh:RC581-607, lcsh:Infectious and parasitic diseases
Published: 2013

38. Energy from gasification of solid wastes

Author: G. De Feo, Vincenzo Belgiorno, R. M. A. Napoli, and C Della Rocca
Subjects: Engineering, Energy recovery, Conservation of Natural Resources, Energy-Generating Resources, Technology, Municipal solid waste, Waste management, business.industry, Biomass, Renewable energy, Refuse Disposal, Electricity generation, Coal gas, Coal, Gases, business, Waste Management and Disposal, Syngas
Abstract: Gasification technology is by no means new: in the 1850s, most of the city of London was illuminated by "town gas" produced from the gasification of coal. Nowadays, gasification is the main technology for biomass conversion to energy and an attractive alternative for the thermal treatment of solid waste. The number of different uses of gas shows the flexibility of gasification and therefore allows it to be integrated with several industrial processes, as well as power generation systems. The use of a waste-biomass energy production system in a rural community is very interesting too. This paper describes the current state of gasification technology, energy recovery systems, pre-treatments and prospective in syngas use with particular attention to the different process cycles and environmental impacts of solid wastes gasification.
Published: 2003

39. Effect of oral contraceptives on lacrimal fluid peroxidase activity in women

Author: Federica Madia, Veronica Liberati, Giordana Marcozzi, and G. de Feo
Subjects: Adult, medicine.medical_specialty, medicine.drug_class, media_common.quotation_subject, Cellular and Molecular Neuroscience, Lacrimal fluid, Reference Values, Internal medicine, medicine, Humans, Menstrual cycle, Menstrual Cycle, media_common, Peroxidase, biology, Estradiol, Chemistry, General Medicine, Plasma levels, Sensory Systems, Enzyme assay, Ophthalmology, Endocrinology, Estrogen, Tears, biology.protein, Female, Ocular surface, Contraceptives, Oral
Abstract: Lacrimal fluid peroxidase has been supposed to be involved in the protection against oxidative damage to the ocular surface. Our recent findings showed the existence of significant cyclic variations in lacrimal fluid peroxidase activity that were positively correlated with those of 17β-estradiol plasma levels throughout the menstrual cycle of fertile women. In the present study lacrimal fluid peroxidase activity of 8 healthy normocyclic women using low-dose oral contraceptives during the monthly cycle was determined. Data showed that low-dose oral contraceptives caused a decrease in lacrimal fluid peroxidase activity and a lack of its cyclic pattern with respect to the enzyme activity of 8 untreated age-matched women. Moreover, this result suggests that lacrimal fluid peroxidase activity could be regulated by estrogen.
Published: 2002

40. [Ovarian abscess due to Actinomyces sp. in absence of an intrauterine contraceptive device]

Author: S C, Burlando, L A, Paz, L G, De Feo, G, Benchetrit, D, Rimoldi, and S C, Predari
Subjects: Adult, Diagnosis, Differential, Ovarian Neoplasms, Teratoma, Humans, Female, Ovarian Diseases, Actinomycosis, Abscess, Intrauterine Devices
Abstract: The disease caused by Actinomyces spp. is often of difficult diagnosis. Actinomyces spp. are anaerobic or microaerophilic non-spore-forming gram-positive rods that may reach, occasionally, the normal female genital tract. IUD and pessaries facilitate the access of the microorganisms to the pelvis. We report an unusual case of ovarian infection by Actinomyces sp. in a 41 year-old female without IUD, admitted at the Institute in November 1998, with persistent fever. She had had an early menopause 3 years before, and had received hormonal replacement therapy. Usual and unusual infections were discarded by microbiological and serologic studies. Abdominal ultrasonography showed a slight left pyelocalycial dilatation and a simple cyst in the left ovary; heart ultrasonography was normal. Gynecological examination showed an enlarged uterus, similar to an 8 week pregnancy, painless, and fixed anexial masses. The transvaginal ultrasonography showed uterine myomas, one of them of 42 mm in the isthmus region, large ovaries, cystic, with acoustic shadows, and the left one with a septum. The preoperative diagnosis was infected bilateral cystic teratoma. The procedure was an exploratory laparotomy, followed by a bilateral salpingo-oophorectomy. The specimen studies showed an endometrioma with calcium deposits in the wall of the right ovary, and an abscess in the left ovary, also with calcification of the wall. The sample from the left abscess developed Actinomyces sp. After surgery, and treatment with penicillin, the fever disappeared. It is important to remark that the ovarian infection by Actinomyces sp. can also occur in patients without an IUD or a pessary; it might cause anexial images that can be interpreted as a tumour, inducing to erroneous diagnosis and treatment.
Published: 2001

41. Variations of lacrimal fluid peroxidase activity in female and male rats

Author: Federica Madia, Veronica Liberati, G. de Feo, and Giordana Marcozzi
Subjects: Male, medicine.medical_specialty, 17β-oestradiol, media_common.quotation_subject, Cellular and Molecular Neuroscience, Sex Factors, Estrus, Lacrimal fluid, Internal medicine, Male rats, medicine, Animals, Rats, Wistar, Progesterone, Menstrual cycle, media_common, Estrous cycle, Estradiol, biology, Lacrimal Apparatus, General Medicine, Plasma levels, biochemical phenomena, metabolism, and nutrition, Sensory Systems, Circadian Rhythm, Rats, Ophthalmology, Endocrinology, Peroxidases, Tears, biology.protein, Female, Peroxidase
Abstract: Previous research from this laboratory showed that human lacrimal fluid peroxidase has cyclic variations during the menstrual cycle, correlated with plasma levels of 17β-oestradiol. In the present investigation, variations of enzyme activity and total protein content during the oestrous cycle of young adult female rats are analysed. Effects from circadian rhythm and a gender-related influence are also examined. In female rats, as in women, lacrimal fluid peroxidase activity shows cyclic variations; in fact, it significantly (p < 0.05) changes during the different phases of the oestrous cycle. In contrast, in males such variations do not occur. Thus, we suggest that gender seems to exert a significant influence on the secretion of this specific tear protein, probably by a direct effect of oestrogens.
Published: 2001

42. Lacrimal fluid peroxidase activity during the menstrual cycle

Author: F G, Marcozzi, F, Madia, G, Del Bianco, E, Mattei, and G, de Feo
Subjects: Adult, Analysis of Variance, Time Factors, Estradiol, Tears, Humans, Female, Saliva, Menstrual Cycle, Progesterone, Peroxidase
Abstract: The aim of this work was to investigate peroxidase activity in human tears during the various phases of the menstrual cycle. For comparative purposes saliva was also examined.Tear fluids and saliva from 10 healthy volunteers 23-41 years of age (mean: 28.2 years), with regular menstrual cycles were sampled for the duration of at least two complete cycles. Menstrual cycles and ovulation periods were evaluated by measuring morning body temperature and hormone levels in plasma and urine. Unstimulated tears and unstimulated saliva were collected in the morning every two days. Peroxidase activity was monitored according to the 5,5'-dithiobis, 2-nitrobenzoic acid thiocyanate (Nbs-SCN) method and the protein content was determined by the Bradford method.Peroxidase activity in tears, expressed as U/mL, was significantly (p.05) higher during the preovulatory and luteal phases with respect to the menses, whilst total protein content remained almost unchanged throughout all phases. A positive correlation was found between lacrimal fluid peroxidase activity and 17beta-estradiol plasma levels (p.001). Salivary peroxidase activity did not show such estrogen-related changes.Our findings report cyclic variations in peroxidase activity in human tears during the menstrual cycle. Such cycling seems to reflect variations of 17 beta-estradiol plasma levels. These results suggest that a regulation of lacrimal fluid peroxidase by 17 beta-estradiol could be one possible cause for the female gender predilection in some ocular diseases, such as keratoconjunctivitis sicca.
Published: 2000

43. Allergic Rhinitis and its Impact on Asthma (ARIA) Phase 4 (2018): Change management in allergic rhinitis and asthma multimorbidity using mobile technology

Author: Bousquet, J. Hellings, P.W. Agache, I. Amat, F. Annesi-Maesano, I. Ansotegui, I.J. Anto, J.M. Bachert, C. Bateman, E.D. Bedbrook, A. Bennoor, K. Bewick, M. Bindslev-Jensen, C. Bosnic-Anticevich, S. Bosse, I. Brozek, J. Brussino, L. Canonica, G.W. Cardona, V. Casale, T. Cepeda Sarabia, A.M. Chavannes, N.H. Cecchi, L. Correia de Sousa, J. Costa, E. Cruz, A.A. Czarlewski, W. De Carlo, G. De Feo, G. Demoly, P. Devillier, P. Dykewicz, M.S. El-Gamal, Y. Eller, E.E. Fonseca, J.A. Fontaine, J.-F. Fokkens, W.J. Guzmán, M.-A. Haahtela, T. Illario, M. Ivancevich, J.-C. Just, J. Kaidashev, I. Khaitov, M. Kalayci, O. Keil, T. Klimek, L. Kowalski, M.L. Kuna, P. Kvedariene, V. Larenas-Linnemann, D. Laune, D. Le, L.T.T. Carlsen, K.L. Lourenço, O. Mahboub, B. Mair, A. Menditto, E. Milenkovic, B. Morais-Almeida, M. Mösges, R. Mullol, J. Murray, R. Naclerio, R. Namazova-Baranova, L. Novellino, E. O'Hehir, R.E. Ohta, K. Okamoto, Y. Okubo, K. Onorato, G.L. Palkonen, S. Panzner, P. Papadopoulos, N.G. Park, H.-S. Paulino, E. Pawankar, R. Pfaar, O. Plavec, D. Popov, T.A. Potter, P. Prokopakis, E.P. Rottem, M. Ryan, D. Salimäki, J. Samolinski, B. Sanchez-Borges, M. Schunemann, H.J. Sheikh, A. Sisul, J.-C. Rajabian-Söderlund, R. Sooronbaev, T. Stellato, C. To, T. Todo-Bom, A.-M. Tomazic, P.-V. Toppila-Salmi, S. Valero, A. Valiulis, A. Valovirta, E. Ventura, M.-T. Wagenmann, M. Wang, D.Y. Wallace, D. Waserman, S. Wickman, M. Yorgancioglu, A. Zhang, L. Zhong, N. Zidarn, M. Zuberbier, T. Aberer, W. Akdis, C.A. Akdis, M. Alberti, M.R. Almeida, R. Angles, R. Arnavielle, S. Asayag, E. Asarnoj, A. Arshad, H. Avolio, F. Bacci, E. Baiardini, I. Barbara, C. Barbagallo, M. Baroni, I. Barreto, B.A. Basagana, X. Bedolla-Barajas, M. Beghé, B. Bel, E.H. Bergmann, K.C. Benson, M. Bertorello, L. Białoszewski, A.Z. Bieber, T. Bialek, S. Bjermer, L. Blain, H. Blasi, F. Blua, A. Bochenska Marciniak, M. Bogus-Buczynska, I. Boner, A.L. Bonini, M. Bonini, S. Bouchard, J. Boulet, L.P. Bourret, R. Braido, F. Briedis, V. Brightling, C.E. Bucca, C. Buhl, R. Buonaiuto, R. Panaitescu, C. Burguete Cabañas, M.T. Burte, E. Bush, A. Caballero-Fonseca, F. Caillot, D. Caimmi, D. Calderon, M.A. Camargos, P.A.M. Camuzat, T. Canfora, G. Carreiro-Martins, P. Carriazo, A.M. Carr, W. Cartier, C. Castellano, G. Chen, Y. Chiron, R. Chivato, T. Chkhartishvili, E. Chuchalin, A.G. Chung, K.F. Ciaravolo, M.M. Ciceran, A. Cingi, C. Ciprandi, G. Carvalho Coehlo, A.C. Colas, L. Colgan, E. Coll, J. Conforti, D. Cortés-Grimaldo, R.M. Corti, F. Costa-Dominguez, M.C. Courbis, A.L. Cox, L. Crescenzo, M. Custovic, A. Dahlen, S.E. Dario, C. da Silva, J. Dauvilliers, Y. Darsow, U. De Blay, F. Dedeu, T. de Fátima Emerson, M. De Vries, G. De Martino, B. de Paula Motta Rubini, N. Deleanu, D. Denburg, J.A. Di Capua Ercolano, S. Di Carluccio, N. Didier, A. Dokic, D. Dominguez-Silva, M.G. Douagui, H. Dray, G. Dubakiene, R. Durham, S.R. Du Toit, G. Eklund, P. Emuzyte, R. Farrell, J. Farsi, A. Ferreira de Mello, J. Ferrero, J. Fink-Wagner, A. Fiocchi, A. Forti, S. Fuentes-Perez, J.M. Gálvez-Romero, J.L. Gamkrelidze, A. Garcia-Aymerich, J. García-Cobas, C.Y. Garcia-Cruz, M.H. Gemicioğlu, B. Genova, S. George, C. Gereda, J.E. Gerth van Wijk, R. Gomez, R.M. Gómez-Vera, J. González Diaz, S. Gotua, M. Grisle, I. Guidacci, M. Guldemond, N.A. Gutter, Z. Hajjam, J. Hernández, L. Hourihane, J.O. Huerta-Villalobos, Y.R. Humbert, M. Iaccarino, G. Jares, E.J. Jassem, E. Johnston, S.L. Joos, G. Jung, K.S. Jutel, M. Kalyoncu, A.F. Karjalainen, J. Kardas, P. Keith, P.K. Khaltaev, N. Kleine-Tebbe, J. Kuitunen, M. Kull, I. Kupczyk, M. Krzych-Fałta, E. Lacwik, P. Lauri, D. Lavrut, J. Lessa, M. Levato, G. Li, J. Lieberman, P. Lipiec, A. Lipworth, B. Lodrup Carlsen, K.C. Louis, R. Luna-Pech, J.A. Maciej, K. Magnan, A. Maier, D. Majer, I. Malva, J. Mandajieva, E. Manning, P. De Manuel Keenoy, E. Marshall, G.D. Masjedi, M.R. Maspero, J.F. Mathieu-Dupas, E. Matta Campos, J.J. Matos, A.L. Maurer, M. Mavale-Manuel, S. Mayora, O. Medina-Avalos, M.A. Melén, E. Melo-Gomes, E. Meltzer, E.O. Mercier, J. Miculinic, N. Mihaltan, F. Moda, G. Mogica-Martinez, M.D. Mohammad, Y. Momas, I. Montefort, S. Monti, R. Mora Bogado, D. Morato-Castro, F.F. Mota-Pinto, A. Moura Santo, P. Münter, L. Muraro, A. Nadif, R. Nalin, M. Napoli, L. Neffen, H. Niedeberger, V. Nekam, K. Neou, A. Nieto, A. Nogueira-Silva, L. Nogues, M. Nyembue, T.D. Odzhakova, C. Ortega Cisneros, M. Ouedraogo, S. Pali-Schöll, I. Papi, A. Passalacqua, G. Pedersen, S. Pépin, J.L. Pereira, A.M. Persico, M. Phillips, J. Picard, R. Pigearias, B. Pin, I. Pitsios, C. Pohl, W. Portejoie, F. Pozzi, A.C. Price, D. Puy, R. Pugin, B. Pulido Ross, R.E. Przemecka, M. Rabe, K.F. Raciborski, F. Reitsma, S. Ribeirinho, I. Rimmer, J. Rivero-Yeverino, D. Rizzo, J.A. Rizzo, M.C. Robalo-Cordeiro, C. Rodenas, F. Rodo, X. Rodriguez Gonzalez, M. Rodriguez-Mañas, L. Rolland, C. Rodrigues Valle, S. Roman Rodriguez, M. Romano, A. Rodriguez-Zagal, E. Rolla, G. Roller-Wirnsberger, R.E. Romano, M. Rosado-Pinto, J. Rosario, N. Sagara, H. Sastre-Dominguez, J. Scadding, G.K. Scichilone, N. Schmid-Grendelmeier, P. Serpa, F.S. Shamai, S. Sierra, M. Simons, F.E.R. Siroux, V. Skrindo, I. Solé, D. Somekh, D. Sondermann, M. Sova, M. Sorensen, M. Sorlini, M. Spranger, O. Stelmach, R. Stukas, R. Sunyer, J. Strozek, J. Szylling, A. Tebyriçá, J.N. Thibaudon, M. Trama, U. Triggiani, M. Suppli Ulrik, C. Urrutia-Pereira, M. Valenta, R. van Eerd, M. van Ganse, E. van Hague, M. Vandenplas, O. Vezzani, G. Vasankari, T. Vatrella, A. Verissimo, M.T. Viart, F. Viegi, M. Vicheva, D. Vontetsianos, T. Walker, S. Werfel, T. Westman, M. Williams, D.M. Williams, S. Wilson, N. Wright, J. Wroczynski, P. Yakovliev, P. Yawn, B.P. Yiallouros, P.K. Yusuf, O.M. Zar, H.J. Zernotti, M.E. Zubrinich, C. Zurkuhlen, A.
Subjects: animal structures
Abstract: Allergic Rhinitis and its Impact on Asthma (ARIA) has evolved from a guideline by using the best approach to integrated care pathways using mobile technology in patients with allergic rhinitis (AR) and asthma multimorbidity. The proposed next phase of ARIA is change management, with the aim of providing an active and healthy life to patients with rhinitis and to those with asthma multimorbidity across the lifecycle irrespective of their sex or socioeconomic status to reduce health and social inequities incurred by the disease. ARIA has followed the 8-step model of Kotter to assess and implement the effect of rhinitis on asthma multimorbidity and to propose multimorbid guidelines. A second change management strategy is proposed by ARIA Phase 4 to increase self-medication and shared decision making in rhinitis and asthma multimorbidity. An innovation of ARIA has been the development and validation of information technology evidence-based tools (Mobile Airways Sentinel Network [MASK]) that can inform patient decisions on the basis of a self-care plan proposed by the health care professional. © 2018 American Academy of Allergy, Asthma & Immunology
Published: 2000

44. Effect of clozapine on dopamine-induced inhibition of prolactin release from cultured rat pituitary cells

Author: Gabriela Mazzanti, C.Y. Cheng, L. Braghiroli, G. De Feo, M. Fiani, and A. Ponzianelli
Subjects: medicine.medical_specialty, medicine.drug_class, Chlorpromazine, Dopamine, Atypical antipsychotic, Pharmacology, Receptors, Dopamine, Prolactin cell, Dopamine receptor D2, Internal medicine, medicine, Fluphenazine, Animals, Humans, Clozapine, Cells, Cultured, Chemistry, Typical antipsychotic, Prolactin, Rats, Endocrinology, Dopamine receptor, Pituitary Gland, cell culture, clozapine, dopamine, prolactin, rat, medicine.drug, Antipsychotic Agents
Abstract: Although the atypical antipsychotic agent clozapine has little propensity to induce hyperprolactinemia in humans it increases serum prolactin levels in the rat. In this study, the effects of clozapine and of some typical antipsychotic drugs on basal and dopamine-mediated prolactin secretion from cultured rat pituitary cells were compared. Despite being less potent than the other antipsychotic agents tested, clozapine reverted the effect of dopamine on prolactin secretion in vitro. This finding suggests that clozapine interferes with dopamine receptors in the pituitary gland.
Published: 1997

45. [Morphologic and ultrastructural changes of soft palate in patients who underwent palatopharyngoplasty]

Author: A, Cimino, R, Speciale, S, Gallina, M, Cimino, G, Cimino, G, De Feo, and F, Aragona
Subjects: Sleep Apnea Syndromes, Uvula, Respiratory System, Humans, Pharynx, Palate, Soft, Respiratory System Abnormalities, Salivary Glands
Abstract: In order to clarify pathogenesis of Obstructive Sleep Apnea Syndrome (OSAS) in patients with anatomic abnormalities of upper airways, we studied soft palate and uvula of OSAS patients by means of histological and ultrastructural techniques. 38 OSAS patients, severe and moderately severe form, underwent modified Palatopharingoplasty. We evaluated only 16 OSAS patients' soft palate and uvula and observed histological changes in all of them: submucosal edema and minor salivary glandes ipertrophy and iperplasy are present. On the contrary, ultramicroscope showed normal muscle fibers. Strie Z alterations and sarcomeres disorganization, although present, have no statistical value. Very probably, ronflement and apneas determined the observed alterations through trauma on pharingeal wall. Therefore, they are not OSAS primary cause.
Published: 1995

46. Metronomic schedule of temozolomide with conventional dose of cisplatin in metastatic melanoma

Author: I. De Michele, Vanna Chiarion-Sileni, Ester Simeone, P.A. Ascierto, Nicola Mozzillo, Giovannella Palmieri, Antonio Daponte, Corrado Caracò, Vincenzo Montesarchio, and G. De Feo
Subjects: Oncology, Cisplatin, Cancer Research, medicine.medical_specialty, Schedule, Temozolomide, Metastatic melanoma, business.industry, Dacarbazine, Standard treatment, Internal medicine, medicine, business, medicine.drug
Abstract: e20009 Background: Dacarbazine (DTIC) is the standard treatment for metastatic melanoma. Temozolomide (TMZ) is a potentially attractive chemotherapeutic agent for this disease because of the oral route of administration and efficacy similar to that of dacarbazine. Cisplatin is active against melanoma and might counteract mechanisms of resistance to TMZ. Metronomic administration of TMZ might be another way to overcome resistance. Patients and Methods: We reviewed data of metastatic melanoma patients treated at our Institutions with cisplatin (75 mg/m2 every 28 days) plus TMZ (75 mg/m2/die from day 2 for 21 days). Our practice included such scheme for patients younger than 75 years, with a performance status not worse than 2, and adequate bone marrow, liver and renal function. Assessment of response was done every 3 cycles. Toxicity was graded according to NCI-CTC. Results: From August 2007 to September 2008, 33 patients were treated with a median age of 44 years (18–74); primary melanoma was ulcerated in 19 cases (58%); most frequent sites of metastases were lung (18 cases), brain and lymph nodes (11 cases each); 29 patients were treated as first-line and 4 as second-line. The median number of delivered cycles was 4 (range 2- 8). Toxicity was mild, with no grade 4 event reported. Nausea and vomiting were the most frequent and severe toxic effects: grade 3 in 2 cases each and grade 2 in 16 and 9 cases, respectively. Other toxicities included thrombocytopenia (2 case grade 3 and 3 cases grade 2), anemia (1 grade 3 and 4 grade 2), neutropenia, and fatigue (1 grade 3 each). Overall, 6 patients had a partial response (18.2%; 95% exact CI: 7.0–35.5) and 8 (24%) had a disease stabilization. With a median follow-up of 20 weeks (95% CI: 19–57), there were 19 progressions and a median progression-free survival of 24 weeks (95% CI:16-nr); 9 patients died with a median survival of 50 weeks (95% CI 43-nr). Conclusions: Results obtained in clinical practice with metronomic temozolomide plus cisplatin in the treatment of patients with metastatic melanoma are encouraging, in light of the negative prognostic features of treated patients. We are now planning a formal phase II study. [Table: see text]
Published: 2009
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47. Endocrine effects of adjuvant letrozole versus tamoxifen in hormone responsive postmenopausal early breast cancer patients: results from the HOBOE randomized trial

Author: Francesco Nuzzo, Giuseppe D'Aiuto, G. Landi, C. Gallo, Adriano Gravina, V. Labonia, G. Botti, G. De Feo, A. De Matteis, Elisa Rossi, F. Perrone, E. De Maio, Carmen Pacilio, Alessandro Morabito, Giuseppe Esposito, Mauro Piccirillo, and F. Di Rella
Subjects: Oncology, Cancer Research, medicine.medical_specialty, business.industry, Letrozole, medicine.medical_treatment, Cancer, medicine.disease, law.invention, Breast cancer, Endocrinology, Randomized controlled trial, law, Internal medicine, medicine, business, Adjuvant, Testosterone, Tamoxifen, medicine.drug, Hormone
Abstract: CTRC-AACR San Antonio Breast Cancer Symposium: 2008 Abstracts Abstract #1150 Purpose. We compared the endocrine effects of 6 and 12 months of adjuvant letrozole versus tamoxifen in postmenopausal patients with hormone responsive early breast cancer, within an ongoing phase 3 trial (HOrmonal adjuvant treatment BOne Effects – HOBOE, ClinicalTrial.gov id: [NCT00412022][1]). Patients and M ethods . Patients were randomised to receive tamoxifen or letrozole ± zoledronate. Serum values of 17-b-estradiol, FSH, LH, testosterone, dehydroepiandrosterone-solphate, progesterone, and cortisol were measured at baseline, after 6 and 12 months of treatment. For each hormone, baseline, 6 and 12-month values were compared between treatment groups, by the exact Wilcoxon-Mann-Whitney test. Results. At December 31, 2006, 157 postmenopausal patients had been enrolled into the study; baseline data were available for 139 patients (88.5%), 43 assigned to tamoxifen and 96 assigned to letrozole. Median age was 61 and 62 years in the two groups, respectively. Baseline values were similar between the two groups for all hormones. At 6 and 12 months, levels of 17-b-estradiol were significantly lower with letrozole as compared with tamoxifen (p=0.0003 and p
Published: 2009
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48. Misleading results in studying pharmacodynamic interaction with oral anticoagulant

Author: G, de Feo, A, Del Vecchio, G, Orticelli, P, Valeri, G, Mazzanti, R, Lisciani, and G, Noli
Subjects: Male, Animals, Anticoagulants, Drug Interactions, Female, Rats, Inbred Strains, Warfarin, Rats
Abstract: We described an experimental condition, in which the i.p. administration of rats of irritants produces a misleading increase of the anticoagulant effect of warfarin. Group of 10 adult Wistar rats were treated i.p. or i.v. with HCl 0.1N plus warfarin p.o.; 24 hr after warfarin administration, prothrombin time was determined on citrate blood specimens and the animals were submitted to autopsy. When HCl is given i.p., a significant increase of prothrombin time is observed. On the contrary following i.v. administration no interference with the anticoagulant effect of warfarin is observed. Abdomen exploration of rats shows the presence of serum exudate following i.p. but not i.v. administration of HCl. The synergistic effect of i.p. administration of HCl on anticoagulant effect of warfarin appears an experimental artifact, probably attributable to a non-specific local irritating effect. This result stresses the need of caution in interpreting animal data indicating a synergism with oral anticoagulant.
Published: 1991

49. [Effects of prolonged administration of dapiprazole in rats]

Author: N, Sopranzi, G, de Feo, S, Pace, A, Del Vecchio, and A R, Bonaventura
Subjects: Male, Time Factors, Fourier Analysis, Animals, Brain, Electroencephalography, Rats, Inbred Strains, Triazoles, Adrenergic alpha-Antagonists, Piperazines, Antipsychotic Agents, Rats
Abstract: In this paper we have studied the rat under chronic treatment with dapiprazole ip. (a drug with alpha-adrenergic blocking properties). For a 4 week period we have recorded, once a week, weight, rectal temperature, tail-flick, general activity and explorative behaviour on rotarod and one-arm radial maze. Surface (SEEG) and deep (DEEG) EEGrams were also recorded at the end of the experiments (4th week). SEEG and DEEG underwent the Fourier analysis (Fast Fourier Transform--see text). The findings were: 1) No change was observed in weight, rectal temperature and tail-flick time, glycemia and haematocrit. 2) Motor coordination on rotaroad dropped in 1st and 3rd week of treatment. 3) The treated rats, when in a one arm radial maze, showed signs of sedation (no grooming) from 2nd week of treatment. 4) SEEG and DEEG recordings showed a slowing activity; Fourier analysis confirmed these results. The slowing of activity (4) well agrees with the signs of sedation and behaviour (2, 3). It seems thus confirmed that alpha-adrenergic blockade is a feature of the drug together with the psychotropic effects previously described.
Published: 1991

50. Apoptotic degeneration induction in retinal cells by acute ocular hypertension and neuroprotection by troxolol

Author: Gianfranco Risuleo, G. Scarsella, G. De Feo, Massimiliano Cristofanilli, and Nicola Pescosolido
Subjects: Pathology, medicine.medical_specialty, Necrosis, genetic structures, business.industry, Ocular hypertension, Retinal, Degeneration (medical), medicine.disease, Neuroprotection, Ophthalmology, chemistry.chemical_compound, chemistry, Apoptosis, Medicine, medicine.symptom, business, Cell damage
Abstract: Summary The effects of acute experimental ocular hypertension on retinal cells have been studied. IOP levels and degree of cell damage have been evaluated by cytochemical and DNA analysis, by which the degeneration, necrotic and apoptotic modalities were observed. Possible pharmacological approaches, e.g. neuroprotection with troxol, have been determined for the prevention of the degenerative events that may be ascribed, at least in part, to oxidizing processes.
Published: 1999
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