288 results on '"G. Danilov"'
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2. The classification of PubMed neurosurgical abstracts using pretrained BERT model
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G. Danilov, T. Ishankulov, K. Kotik, Y. Orlov, M. Shifrin, and A. Potapov
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Neurology. Diseases of the nervous system ,RC346-429 - Published
- 2021
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3. Cerebral hyperperfusion syndrome after ECIC bypass surgeries. Prognostic formula for its risk assessment
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A. Nemirovskiy, T. Nemirovskaya, A. Kokshin, G. Danilov, and V. Danilov
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Neurology. Diseases of the nervous system ,RC346-429 - Published
- 2021
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4. Transsylvian insular glioma surgery: new classification system, clinical outcome in a consecutive series of 79 cases
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D. Pitskhelauri, A. Bykanov, A. Konovalov, G. Danilov, S. Buklina, and R. Rinat
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Neurology. Diseases of the nervous system ,RC346-429 - Published
- 2021
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5. Inter-rater reliability of information extraction from clinical notes in neurosurgery: human expertise vs. machine learning
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G. Danilov, A. Kosyrkova, M. Shults, S. Melchenko, T. Tsukanova, M. Shifrin, and A. Potapov
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Neurology. Diseases of the nervous system ,RC346-429 - Published
- 2021
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6. Prospects for the use of various species and strains of symbiotic bacteria (Xenorhabdus sp.) in the biological protection of potatoes from diseases in the European North of Russia
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Z. P. Kotova, T. A. Danilova, L. G. Danilov, and M. V. Arkhipov
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xenorhabdus bovienii entopathogenic nematodes ,potato ,streptomyces scabies (thaxter) waksman & henrici ,rhizoctonia solani j. g. kuhn ,phytophtora infestans (montagne) de bary ,phoma exigua var. exigua ,Agriculture - Abstract
Research on the development of environmentally friendly plant protection systems against fungal pathogens using symbiotic bacteria Xenorhabdus sp. – symbionts of entomopathogenic nematodes (EPN) has been a new direction in agricultural practice in recent years and undoubtedly represent relevance and scientific significance. The studies used suspensions of live and autoclaved cultures of symbiotic bacteria of symbionts of various types of EPN (Steinernema carpocapsae, S. feltiae and S. feltiae protense) with a bacterial cell titer of 107 CFU/ml in comparison with the biological preparation Phytosporin-M (dough) and water as a control. In laboratory conditions at a temperature of 25 oC, there were established differences in the antibiotic activity of the primary forms of producers of Xenorhabdus sp., isolated from different types of EPN. The greatest inhibition of the fungal growth zone on the 4th day was observed for metabolites of the S. carpocapsae strain against Alternaria solani. Biological effectiveness in suppressing this pathogen was 51 %. Field research conducted in 2022-2023 in the conditions of the Republic of Karelia on the mid-early potato variety ʻRed Scarlettʼ, showed that under epiphytotic conditions (low air temperatures and excessive waterlogging) double spraying of vegetative plants with a suspension of live and autoclaved cultures of symbiotic bacteria (EPN-1-1, EPN-2 and EPN-2 -1) reduced the development of rhizoctoniosis compared to the control variant by 50, 64 and 60 %, respectively. It was found that double treatment with a live and autoclaved aqueous suspension of bacteria, symbionts of the subspecies S. feltiae was more effective and ensured a reduction in the degree of development of scab symptoms by 1.3–2.8 times and the spread of rhizoctonia by 1.5–2.0 times. It has been also established that 2-fold spraying of plants with a live and autoclaved suspension of symbiotic bacteria S. feltiae during the growing season significantly increases the yield of tubers by 35–22 %, respectively. Thus, the use of biologically active secondary metabolites of Xenorhabdus sp. has significant potential as biological plant protection agents against potato pathogens.
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- 2024
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7. Efficacy and safety of the combined use of celecoxib, diacerein and a combination of glucosamine and chondroitin for the control of musculoskeletal pain associated with osteoarthritis and nonspecific back pain
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A. E. Karateev, E. Yu. Polishchuk, A. M. Lila, A. N. Ananyev, L. V. Ananyeva, A. V. Bondarev, A. A. Bondareva, A. R. Bukanbaeva, S. V. Vorster, S. A. Gadzhieva, D. G. Danilov, R. I. Eliseev, I. S. Zabelin, M. Yu. Ignatenko, I. V. Itkina, A. E. Kolesnikov, M. Yu. Konoplyanskaya, Yu. G. Krasnoyarova, S. I. Kukushkin, V. A. Lila, O. V. Makareva, V. S. Myagkikh, I. V. Nelgovskaya, N. V. Ocheredko, R. A. Panov, I. A. Polyakov, A. S. Prozorov, S. S. Rubina, M. E. Ryabochkina, M. A. Takhaev, E. R. Tokareva, T. V. Tolbina, M. I. Fominykh, V. V. Tsarev, E. I. Sharipova, M. V. Sheven, G. I. Shcherbakov, and S. A. Yanchenkova
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osteoarthritis ,chronic nonspecific low back pain ,celecoxib ,diacerein ,glucosamine ,chondroitin ,combination therapy ,Medicine - Abstract
The combined use of drugs with different mechanisms of action is the main principle of musculoskeletal pain control in rheumatic diseases. However, there are few studies evaluating the efficacy of this approach in real practice.Objective: to determine the efficacy and safety of the combined use of celecoxib, diacerein, and the combination of glucosamine + chondroitin in osteoarthritis (OA) and chronic nonspecific low back pain (NSLBP). Material and methods. Statistical analysis of data obtained during a 3-month open observational study was performed. We included 1569 patients (63.6 % women and 36.4 % men, mean age 58.7 ± 11.0 years) with knee OA (kOA), hip OA (hOA), generalized OA (gOA), and chronic NSLBP with moderate/severe pain (≥ 4 on a numeric rating scale, NRS 0–10) who required nonsteroidal anti-inflammatory drugs. Celecoxib 200 mg twice daily was prescribed, with the dose reduced to 200 mg per day or taken “as needed" after significant pain relief; diacerein 50 mg twice daily; and a medication of glucosamine 250 mg and chondroitin 200 mg, 2 capsules 2–3 times daily. Outcomes were assessed after 3 months using the dynamics of pain, fatigue, dysfunction (according to NRS), and the “Patient Acceptable Symptom State” (PASS) indicator. Results and discussion. 80.2 % of patients completed the 3 month course of treatment, 4.4 % discontinued treatment due to adverse events (AEs), and for 15.4 % of patients there was no follow-up. After 3 months of treatment ≥ 50 % decrease (from baseline) in the severity of symptoms was noted in 83.4 % of patients for pain on movement, in 83.7 % for pain at rest, in 78.6 % for pain at night, in 80.8 % for dysfunction, and in 83.4 % for fatigue. 87.7 % of patients reported PASS. There were no significant differences in treatment outcomes for different localizations of OA and NSLBP: a ≥ 50 % pain reduction in kOA was achieved in 81.6 % of patients, in hOA – in 82.2 %, in gOA – in 85.0 %, in NSLBP – in 88.1 %. AEs were registered in 350 (22.4 %) patients, the most frequent was dyspepsia (n = 280, 17.8 %), diarrhea was recorded in 37 (2.4 %) cases. No serious AEs requiring hospitalization were registered. Conclusion. Combination therapy with celecoxib, diacerein, and a combination of glucosamine and chondroitin significantly reduces the severity of symptoms of OA and NSLBS.
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- 2023
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8. Heating Structure of the Second Half of the XVIII Century (based on the archaeological materials of Tobolsk)
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Natalya P. Turova and Petr G. Danilov
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archaeology ,western siberia ,tobolsk ,xviii century ,estate ,furnace ,tiles ,bricks ,stamps ,Archaeology ,CC1-960 - Abstract
This study deals with description of the furnace structure, studied during archaeological work on the territory of the upper part of one of the oldest towns in Siberia – Tobolsk (founded in 1587). Stratigraphic surveys together with a numismatic collection allowed the authors to date the revealed heating structure to the second half of the XVIII century. It was established that the furnace was built at the bottom of the cellar; its base was a frame of scaffolds, on which the brickwork was made (the reuse of bricks from pulled down furnaces was recorded). The studied part of the furnace base has been preserved to a height of 1 m; the maximum studied dimensions are 170×160 cm. Based on the analysis of the masonry, the furnace found to be rectangular in shape. It was decorated with tiles. The authors believe that the studied furnace design is not typical for Tobolsk of the second half of the XVIII century. It was in the house of a wealthy citizen.
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- 2023
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9. Gene Expression Analysis of Yeast Strains with a Nonsense Mutation in the eRF3-Coding Gene Highlights Possible Mechanisms of Adaptation
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Evgeniia M. Maksiutenko, Yury A. Barbitoff, Lavrentii G. Danilov, Andrew G. Matveenko, Olga M. Zemlyanko, Elena P. Efremova, Svetlana E. Moskalenko, and Galina A. Zhouravleva
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translation termination ,release factors ,yeast ,eRF3 ,nonsense mutations ,cell cycle ,Biology (General) ,QH301-705.5 ,Chemistry ,QD1-999 - Abstract
In yeast Saccharomyces cerevisiae, there are two translation termination factors, eRF1 (Sup45) and eRF3 (Sup35), which are essential for viability. Previous studies have revealed that presence of nonsense mutations in these genes leads to amplification of mutant alleles (sup35-n and sup45-n), which appears to be necessary for the viability of such cells. However, the mechanism of this phenomenon remained unclear. In this study, we used RNA-Seq and proteome analysis to reveal the complete set of gene expression changes that occur during cellular adaptation to the introduction of the sup35-218 nonsense allele. Our analysis demonstrated significant changes in the transcription of genes that control the cell cycle: decreases in the expression of genes of the anaphase promoting complex APC/C (APC9, CDC23) and their activator CDC20, and increases in the expression of the transcription factor FKH1, the main cell cycle kinase CDC28, and cyclins that induce DNA biosynthesis. We propose a model according to which yeast adaptation to nonsense mutations in the translation termination factor genes occurs as a result of a delayed cell cycle progression beyond the G2-M stage, which leads to an extension of the S and G2 phases and an increase in the number of copies of the mutant sup35-n allele.
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- 2024
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10. Does Background Matter? A Comparative Characterization of Mouse Models of Autosomal Retinitis Pigmentosa rd1 and Pde6b-KO
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Angelina V. Chirinskaite, Alexander Yu. Rotov, Mariia E. Ermolaeva, Lyubov A. Tkachenko, Anastasia N. Vaganova, Lavrentii G. Danilov, Ksenia N. Fedoseeva, Nicolay A. Kostin, Julia V. Sopova, Michael L. Firsov, and Elena I. Leonova
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retinitis pigmentosa ,pde6b ,β-subunit of phosphodiesterase ,electroretinography ,Pde6b-KO ,Biology (General) ,QH301-705.5 ,Chemistry ,QD1-999 - Abstract
Many retinal degenerative diseases result in vision impairment or permanent blindness due to photoreceptor loss or dysfunction. It has been observed that Pde6brd1 mice (rd1), which carry a spontaneous nonsense mutation in the pde6b gene, have a strong phenotypic similarity to patients suffering from autosomal recessive retinitis pigmentosa. In this study, we present a novel mouse model of retinitis pigmentosa generated through pde6b gene knockout using CRISPR/Cas9 technology. We compare this Pde6b-KO mouse model to the rd1 mouse model to gain insights into the progression of retinal degeneration. The functional assessment of the mouse retina and the tracking of degeneration dynamics were performed using electrophysiological methods, while retinal morphology was analyzed through histology techniques. Interestingly, the Pde6b-KO mouse model demonstrated a higher amplitude of photoresponse than the rd1 model of the same age. At postnatal day 12, the thickness of the photoreceptor layer in both mouse models did not significantly differ from that of control animals; however, by day 15, a substantial reduction was observed. Notably, the decline in the number of photoreceptors in the rd1 model occurred at a significantly faster rate. These findings suggest that the C3H background may play a significant role in the early stages of retinal degeneration.
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- 2023
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11. Data on RNA-seq analysis of the oviducts of five closely related species genus Littorina (Mollusca, Caenogastropoda): L. saxatilis, L. arcana, L. compressa, L. obtusata, L. fabalis
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Arseniy A. Lobov, Lavrentii G. Danilov, Alexey E. Masharskiy, Alexander V. Predeus, Natalia A. Mikhailova, Andrei I. Granovitch, and Arina L. Maltseva
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Littorina ,L. saxatilis ,L. obtusata ,RNA-seq ,Ovoviviparity ,Mollusca ,Computer applications to medicine. Medical informatics ,R858-859.7 ,Science (General) ,Q1-390 - Abstract
In the evolution of invertebrates, the transition from egg-layers to brooders occurred many times. However, the molecular mechanisms underlying this transition are still not well understood. Recently diverged species genus Littorina (Mollusca, Gastropoda, Caenogastropoda, Littorinimorpha): Littorina saxatilis, L. arcana, L. compressa, L. obtusata and L. fabalis might be a fruitful model for elucidation of these mechanisms. All five species sympatrically inhabit an intertidal zone. Only L. saxatilis is ovoviviparous while the other four species form clutches. Although in L. saxatilis jelly gland of the pallial oviduct function as a brood pouch, it is not deeply modified at the morphological level in comparison to egg-laying relatives. Comparative analysis of transcriptomic profiles of the pallial oviducts of these closely related species might help to uncover the molecular mechanisms of the egg-laying to brooding transition. Unraveling of the mechanisms underlying this transition in L. saxatilis is important not only in aspects of reproduction biology and strategy, but also in a broader view as an example of relatively fast evolutionary transformations. We generated an RNA-seq dataset (224 104 446 clean reads) for oviducts of five species genus Littorina. Libraries of all five species were sequenced using Illumina HiSeq 2500; additional reads for L. arcana were obtained using Illumina NovaSeq 6000. Transcriptomic profiles were analyzed in pooled samples (of three individuals) with two biological replicates for each species (each biological replicate was prepared and sequenced as a separate library). The transcriptome was assembled de novo and annotated with five assembles corresponding to each species. The raw data were uploaded to the SRA database, the BioProject IDs are PRJNA662103 (“obtusata” group) and PRJNA707549 (“saxatilis” group).
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- 2022
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12. Burial Practice of Russian Population in Tobolsk Irtysh Region in 18th-19th Centuries: Cases of Deviations from Official Legislation
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P. G. Danilov
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tobolsk irtysh region ,tobolsk spiritual consistory ,abalak male monastery ,russians ,funeral rites ,infant burial ,Slavic languages. Baltic languages. Albanian languages ,PG1-9665 - Abstract
The article deals with the issue of non-compliance with the legislation in the burial practice of the Russian population of the Tobolsk Irtysh region in the 18th-19th centuries. The archival materials of the Fund of the Tobolsk Spiritual Consistory of the State Archive in Tobolsk, reflecting the cases of deviation from the legally established practice of burial, are introduced into scientific circulation. The materials of records management on the facts of the death of a newborn child of the settler Ivan Minin in 1774, who died unbaptized, are analyzed, as well as the death and burial of the peasant Alexey Vakhrushev made without the consent of the civil authorities in 1815 in the territory of the Abalak Znamensky monastery. As a source for the reconstruction of the funeral rites of the Russian population of Siberia, the materials obtained as a result of archaeological research of two children’s burials from the Russian settlement “Yarkova village” in the Tobolsk Irtysh region are involved. Based on the analysis of the features of the burial rite, the burials are dated by the middle of the 19th - early 20th centuries. In connection with the absence of other burials nearby, it is concluded that these burials are a “home” (family) cemetery of unbaptized babies, located in the garden near the cliff, free from economic activity on the site of the peasant estate.
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- 2018
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13. Gut microbiota in chronic liver diseases in children
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G. V. Volynets, A. V. Nikitin, T. A. Skvortsova, A. S. Potapov, V. V. Dudurich, and L. G. Danilov
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Pediatrics, Perinatology and Child Health - Abstract
The impact of gut microbiota on the development of various diseases is of great interest to researchers. However, data on the taxonomic diversity of the intestinal microbiota in chronic liver diseases in children are lacking.Purpose. To study the taxonomic diversity of the fecal microbiota in children with chronic liver diseases in comparison with healthy patients.Material and methods. A metagenomic analysis of the intestinal microbiota of 24 children with chronic liver diseases (mean age 10.3 ± 4.7 years) was carried out with the isolation of the target fragment of the 16S rRNA gene. The group included 18 children with autoimmune liver diseases and 6 children with non-autoimmune liver diseases. The comparison group consisted of fecal samples of 34 apparently healthy children.Results. The conducted study revealed 684 types of microorganisms in the studied samples of patients’ feces. An analysis of the conducted studies showed that fecal samples of healthy children and patients with chronic liver diseases differ in bacterial diversity. The dominant taxa in healthy children were Neisseria flavescens, in patients with chronic liver diseases, the dominant taxa were Bifidobacterium longum, Bifidobacterium adolescentis, Blautia massiliensis. At the same time, Bifidobacterium longum, Bifidobacterium adolescentis, Blautia massiliensis in fecal samples of patients with chronic liver diseases was 8 times as high.Conclusion. Studies have shown differences in the composition of the intestinal microbiota in healthy children and children with chronic liver diseases.
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- 2023
14. The Sea Turtle Tasbacka aldabergeni Nessov, 1987 from the Lower Paleogene Deposits of the Kudinovka Locality (Rostov Province, Russia)
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E. A. Zvonok, K. S. Benitskiy, and I. G. Danilov
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Paleontology - Published
- 2023
15. Phylogeography of the closely related Littorina (Neritrema) species in the North-East Atlantic
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A. L. Maltseva, M. A. Panova, M. A. Varfolomeeva, D. V. Vikhreva, D. V. Smutin, P. A. Pavlova, G. P. Maslakov, L. G. Danilov, N. A. Mikhailova, and A. I. Granovitch
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Animal Science and Zoology ,Ecology, Evolution, Behavior and Systematics - Published
- 2022
16. Asymptotic Multiscale Solutions to Navier–Stokes Equations with Fast Oscillating Perturbations in Boundary Layers
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V. G. Danilov and R. K. Gaydukov
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Statistical and Nonlinear Physics ,Mathematical Physics - Published
- 2022
17. Asymptotic Solutions of Flow Problems with Boundary Layer of Double-Deck Structures
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R. K. Gaydukov and V. G. Danilov
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General Mathematics - Published
- 2022
18. Design of a New [PSI+]-No-More Mutation in SUP35 With Strong Inhibitory Effect on the [PSI+] Prion Propagation
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Lavrentii G. Danilov, Andrew G. Matveenko, Varvara E. Ryzhkova, Mikhail V. Belousov, Olga I. Poleshchuk, Daria V. Likholetova, Petr A. Sokolov, Nina A. Kasyanenko, Andrey V. Kajava, Galina A. Zhouravleva, and Stanislav A. Bondarev
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[PSI+] ,amyloid ,ArchCandy ,prion ,Saccharomyces cerevisiae ,SUP35 mutation ,Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 - Abstract
A number of [PSI+]-no-more (PNM) mutations, eliminating [PSI+] prion, were previously described in SUP35. In this study, we designed and analyzed a new PNM mutation based on the parallel in-register β-structure of Sup35 prion fibrils suggested by the known experimental data. In such an arrangement, substitution of non-charged residues by charged ones may destabilize the fibril structure. We introduced Q33K/A34K amino acid substitutions into the Sup35 protein, corresponding allele was called sup35-M0. The mutagenized residues were chosen based on ArchCandy in silico prediction of high inhibitory effect on the amyloidogenic potential of Sup35. The experiments confirmed that Sup35-M0 leads to the elimination of [PSI+] with high efficiency. Our data suggested that the elimination of the [PSI+] prion is associated with the decreased aggregation properties of the protein. The new mutation can induce the prion with very low efficiency and is able to propagate only weak [PSI+] prion variants. We also showed that Sup35-M0 protein co-aggregates with the wild-type Sup35 in vivo. Moreover, our data confirmed the utility of the strategy of substitution of non-charged residues by charged ones to design new mutations to inhibit a prion formation.
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- 2019
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19. Identification of New FG-Repeat Nucleoporins with Amyloid Properties
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Lavrentii G. Danilov, Xenia V. Sukhanova, Tatiana M. Rogoza, Ekaterina Y. Antonova, Nina P. Trubitsina, Galina A. Zhouravleva, and Stanislav A. Bondarev
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Inorganic Chemistry ,Organic Chemistry ,General Medicine ,Physical and Theoretical Chemistry ,nucleoporins ,amyloids ,ArchCandy ,C-DAG ,evolution ,FG-repeats ,Molecular Biology ,Spectroscopy ,Catalysis ,Computer Science Applications - Abstract
Amyloids are fibrillar protein aggregates with a cross-β structure. More than two hundred different proteins with amyloid or amyloid-like properties are already known. Functional amyloids with conservative amyloidogenic regions were found in different organisms. Protein aggregation appears to be beneficial for the organism in these cases. Therefore, this property might be conservative for orthologous proteins. The amyloid aggregates of the CPEB protein were suggested to play an important role in the long-term memory formation in Aplysia californica, Drosophila melanogaster, and Mus musculus. Moreover, the FXR1 protein demonstrates amyloid properties among the Vertebrates. A few nucleoporins (e.g., yeast Nup49, Nup100, Nup116, and human Nup153 and Nup58), are supposed or proved to form amyloid fibrils. In this study, we performed wide-scale bioinformatic analysis of nucleoporins with FG-repeats (phenylalanine–glycine repeats). We demonstrated that most of the barrier nucleoporins possess potential amyloidogenic properties. Furthermore, the aggregation-prone properties of several Nsp1 and Nup100 orthologs in bacteria and yeast cells were analyzed. Only two new nucleoporins, Drosophila melanogaster Nup98 and Schizosaccharomyces pombe Nup98, aggregated in different experiments. At the same time, Taeniopygia guttata Nup58 only formed amyloids in bacterial cells. These results rather contradict the hypothesis about the functional aggregation of nucleoporins.
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- 2023
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20. The easternmost record of the largest anguine lizard that has ever lived – Pseudopus pannonicus (Squamata, Anguidae): new fossils from the late Neogene of Eastern Europe
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Erwan Loréal, Elena V. Syromyatnikova, Igor G. Danilov, and Andrej Čerňanský
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Pliocene ,Anguimorpha ,North Caucasus ,Miocene ,Moldova ,Ukraine - Abstract
We here report on new material of Pseudopus pannonicus, the iconic and largest-known representative of the lizard clade Anguinae, from several late Neogene localities across Moldova, Ukraine, and regions of the North Caucasus – the last representing the easternmost known occurrence of this extinct species. Today, Pseudopus apodus, the last extant Pseudopus representative, is found in a variety of habitats ranging from South-East Europe to Central Asia. In the late Cenozoic of Europe, however, several extinct species of Pseudopus existed. Among them, interestingly, P. pannonicus displayed the largest spatiotemporal range of the genus, occurring from Spain to the North Caucasus and known from the Late Miocene to the Early Pleistocene. Although it has been reported in a plethora of European localities, P. pannonicus is a taxon “with several questionings related to its few diagnostic features vs. numerous features shared with P. apodus”. The elements described here exhibit some variability, but their overall morphology undoubtedly resembles that of previously described material of P. pannonicus. The lacrimal from Tatareshty, moreover, represents the first fossil lacrimal reported for P. pannonicus. Besides, the fairly complete maxilla with a length of almost 3.7 cm is the largest maxilla ever reported for this taxon, expanding our knowledge of its gigantism. In addition, several features are described and discussed regarding their diagnostic relevance for P. pannonicus. The relationship between body size and some of these features was tested statistically. Consequently, two cranial characters and one vertebral feature peculiar to P. pannonicus were retained in the diagnosis of the species.
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- 2023
21. Treatment of patient with open fracture of ulnar bone
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A. L. Kameka, S. N. Leonova, and D. G. Danilov
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secondary surgical treatment of wound ,ultrasound treatment of wounds ,laceration repair of wound with local tissues ,chronic purulent infection ,bone defect ,Science - Abstract
The article presents the result of treatment of patient P. with trauma caused by an attack of a bear during the hunting. Patient had open comminuted displaced fracture of the lower third of right ulnar bone with formation of large infected wound of right forearm and right hand with injury of flexor tendons of IV and V fingers, extensor tendon of V finger, ulnar nerve. At the admission to the Central District Hospital of Mama, primary surgical treatment of wound, plaster immobilization were conducted, wound weren't stitched up. At the treatment in Irkutsk Scientific Center of Surgery and Traumatology, secondary surgical treatment of wound of right forearm, necretomy, ultrasound treatment of wound, laceration repair of wound with local tissues, transosseous osteosynthesis of right forearm - hand were conducted. As a result of conducted treatment we achieved total reduction of necrotic and purulent process, repair of vast infected wound of forearm and hand, full adhesion of fracture of ulnar bone and restoration of a function of right arm. Using ultrasound treatment of wounds and transosseous osteosynthesis at openfractures of forearm bones and chronic purulent infection is a treatment of choice and can cause good clinical outcome.
- Published
- 2015
22. Processing of Fluorescent Proteins May Prevent Detection of Prion Particles in [PSI+] Cells
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Andrew G. Matveenko, Varvara E. Ryzhkova, Natalia A. Zaytseva, Lavrentii G. Danilov, Anastasia S. Mikhailichenko, Yury A. Barbitoff, and Galina A. Zhouravleva
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General Immunology and Microbiology ,yeast ,prion ,[PSI+] ,Sup35 ,GFP ,RFP ,mCherry ,General Agricultural and Biological Sciences ,General Biochemistry, Genetics and Molecular Biology - Abstract
Yeast is a convenient model for studying protein aggregation as it is known to propagate amyloid prions. [PSI+] is the prion form of the release factor eRF3 (Sup35). Aggregated Sup35 causes defects in termination of translation, which results in nonsense suppression in strains carrying premature stop codons. N-terminal and middle (M) domains of Sup35 are necessary and sufficient for maintaining [PSI+] in cells while preserving the prion strain’s properties. For this reason, Sup35NM fused to fluorescent proteins is often used for [PSI+] detection and investigation. However, we found that in such chimeric constructs, not all fluorescent proteins allow the reliable detection of Sup35 aggregates. Particularly, transient overproduction of Sup35NM-mCherry resulted in a diffuse fluorescent pattern in the [PSI+] cells, while no loss of prions and no effect on the Sup35NM prion properties could be observed. This effect was reproduced in various unrelated strain backgrounds and prion variants. In contrast, Sup35NM fused to another red fluorescent protein, TagRFP-T, allowed the detection of [PSI+] aggregates. Analysis of protein lysates showed that Sup35NM-mCherry is actively degraded in the cell. This degradation was not caused by vacuolar proteases and the ubiquitin-proteasomal system implicated in the Sup35 processing. Even though the intensity of this proteolysis was higher than that of Sup35NM-GFP, it was roughly the same as in the case of Sup35NM-TagRFP-T. Thus, it is possible that, in contrast to TagRFP-T, degradation products of Sup35NM-mCherry still preserve their fluorescent properties while losing the ability to decorate pre-existing Sup35 aggregates. This results in diffuse fluorescence despite the presence of the prion aggregates in the cell. Thus, tagging with fluorescent proteins should be used with caution, as such proteolysis may increase the rate of false-negative results when detecting prion-bearing cells.
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- 2022
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23. モンゴルコク ゴビ サバク ノ ジョウブ ハクアケイ ヨリ サンシタ キョウリュウルイ カメルイ オヨビ ジョウキルイ カセキ ニ カンスル ブンルイガクテキ ケントウ
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Akio, Takahashi, Futo, Kubo, Hokuto, Saito, Masanori, Shimada, Purevsren, Byambaa, Igor G., Danilov, Buuvei, Mainbayar, Mototaka, Saneyoshi, Shinobu, Ishigaki, Khishigjav, Tsogtbaatar, 岡山理科大学生物地球学部, モンゴル科学アカデミー古生物学研究所, ロシア科学アカデミー動物学研究所, 岡山理科大学古生物学・年代学研究センター, Institute of Paleontology, Mongolian Academy of Sciences, and Institute of Paleontology and Geochronology, Okayama University of Science
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- 2022
24. Northernmost occurrences of plesiosaurs and turtles in the Upper Cretaceous of Eurasia
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Nikolay G. Zverkov, Mikhail A. Rogov, Viktor A. Zakharov, Igor G. Danilov, Dmitry V. Grigoriev, and Martin Košťák
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Paleontology - Published
- 2023
25. Development of Maslov’s Approach to the Construction of Nonoscillating WKB-Type Solutions
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Vladimir G. Danilov and M. A. Rakhel
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Degenerate energy levels ,Mathematics::Analysis of PDEs ,Fundamental solution ,Representation (systemics) ,Applied mathematics ,Initial value problem ,Statistical and Nonlinear Physics ,Development (differential geometry) ,Type (model theory) ,Parabolic partial differential equation ,Mathematical Physics ,WKB approximation ,Mathematics - Abstract
In this paper, we show how to construct an asymptotic representation of the fundamental solution to the Cauchy problem for degenerate linear parabolic equations. DOI 10.1134/S1061920821020047
- Published
- 2021
26. A nomenclature for fossil and living turtles using phylogenetically defined clade names
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Tyler R. Lyson, Adán Pérez-García, Juliana Sterli, Andrew D. Gentry, James F. Parham, Márton Rabi, Georgios L. Georgalis, Edwin A. Cadena, Jérémy Anquetin, Igor G. Danilov, Serjoscha W. Evers, Julien Claude, Gabriel S. Ferreira, Natasha S. Vitek, Walter G. Joyce, University of Zurich, Joyce, Walter G, and Parham, James F
- Subjects
0106 biological sciences ,010506 paleontology ,10125 Paleontological Institute and Museum ,PhyloCode ,010603 evolutionary biology ,01 natural sciences ,Phylogenetic nomenclature ,Paleontology ,Phylonyms ,lcsh:GN282-286.7 ,Extant taxon ,lcsh:Fossil man. Human paleontology ,Clade ,Nomenclature ,lcsh:QE701-760 ,0105 earth and related environmental sciences ,Phylogenetic tree ,Palaeontology ,Testudinata ,1911 Paleontology ,Geography ,560 Fossils & prehistoric life ,Evolutionary biology ,lcsh:Paleontology ,Testudines - Abstract
Over the last 25 years, researchers, mostly paleontologists, have developed a system of rank-free, phylogenetically defined names for the primary clades of turtles. As these names are not considered established by the PhyloCode, the newly created nomenclatural system that governs the naming of clades, we take the opportunity to convert the vast majority of previously defined clade names for extinct and extant turtles into this new nomenclatural framework. Some previously defined names are converted with minor adjustments. We also define a number of new clade names to close apparent nomenclatural gaps. In total, we establish 113 clade names, of which 79 had already received phylogenetic definitions and 34 are new.
- Published
- 2021
27. Transcriptome analysis of crown gall in radish ( <scp> Raphanus sativus </scp> L.) inbred lines
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I. E. Dodueva, Lavrenty G. Danilov, Alexander Tkachenko, M. S. Gancheva, Alexander V. Predeus, Ludmila L. Lutova, and V. E. Tvorogova
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Transcriptome ,Inbred strain ,biology ,Botany ,Crown (botany) ,Raphanus ,Gall ,Agrobacterium tumefaciens ,biology.organism_classification ,Agronomy and Crop Science - Published
- 2021
28. Development, verification and application of the KORSAR/LMR computer code
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D. V. Benediktov, A.V. Vakarin, A.O. Popov, A.V. Yarushina, A.V. Mitskevich, S. N. Volkova, and I. G. Danilov
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Source code ,Development (topology) ,Computer science ,business.industry ,media_common.quotation_subject ,Software engineering ,business ,media_common - Published
- 2021
29. Early Jurassic palaeopolar marine reptiles of Siberia
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Nikolay G. Zverkov, Igor G. Danilov, and Dmitry V. Grigoriev
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010506 paleontology ,biology ,Polar night ,Fauna ,Geology ,010502 geochemistry & geophysics ,biology.organism_classification ,01 natural sciences ,Temnodontosaurus ,Stenopterygius ,Plesiosauria ,Paleontology ,Geography ,Taxon ,Polar seas ,Marine reptile ,0105 earth and related environmental sciences - Abstract
Marine reptile occurrences are rare in the Lower Jurassic Series outside of Europe. Here we describe diverse marine reptile faunas from the Lower Jurassic Series (Pliensbachian and Toarcian stages, including the Toarcian–Aalenian boundary interval) of Eastern Siberia. The taxonomic composition of Toarcian marine reptile assemblages of Siberia highlight their cosmopolitan nature, with the presence of taxa previously known nearly exclusively from coeval strata of Europe, such as ichthyosaurians Temnodontosaurus and Stenopterygius, microcleidid plesiosaurians (including the genus Microcleidus), rhomaleosaurids and basal pliosaurids. The palaeogeographic reconstruction places these faunas to the palaeopolar region, north of the 80th northern parallel and up to the palaeo north pole (upper value within the 95% confidence interval for some of the localities). The materials include remains of both mature and juvenile (or even infant, judging by their very small size and poor ossification) animals, indicating a possibility that these polar seas may serve as a breeding area. The diversity and abundance of plesiosaurians and ichthyosaurians, along with a lack of thalattosuchian remains (considering their wide distribution elsewhere at low latitudes), is an additional argument that plesiosaurians and neoichthyosaurians were able to live and reproduce in a polar environment. There is no certainty whether these animals lived in polar seas permanently, or whether they were taking seasonal migrations. However, given the polar night conditions at high latitudes, the latter seems more plausible, and both these scenarios are further indirect evidence that these groups likely had a high metabolism.
- Published
- 2020
30. First reliable records of the genus Chersine (Testudines: Testudinidae) from the Pliocene of Moldova
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Oleg Redkozubov, Elena V. Syromyatnikova, Anna N. Gnetneva, and Igor G. Danilov
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0106 biological sciences ,010506 paleontology ,Paleontology ,Geography ,Genus ,Shell (structure) ,General Agricultural and Biological Sciences ,010603 evolutionary biology ,01 natural sciences ,0105 earth and related environmental sciences - Abstract
The shell remains of tortoises of the genus Chersine (= Eurotestudo) are described from the early Pliocene of the Musait and Colibasi localities of Moldova. The incomplete shell from the Musait loc...
- Published
- 2020
31. Weak Asymptotics Method Approach to the Problem of $$\delta$$-Shock Wave Interactions
- Author
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Vladimir G. Danilov
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Shock wave ,Delta ,General Mathematics ,010102 general mathematics ,Mathematics::Analysis of PDEs ,02 engineering and technology ,Gas dynamics ,01 natural sciences ,020303 mechanical engineering & transports ,0203 mechanical engineering ,Gravitational singularity ,0101 mathematics ,Mathematics ,Mathematical physics - Abstract
In this note, we present an unusual picture of interaction of singularities for pressureless gas dynamics.
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- 2020
32. Calculation of the Singularity Dynamics for Quadratic Nonlinear Hyperbolic Equations. Example: the Hopf Equation
- Author
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Vladimir G. Danilov and Georgii A. Omel’yanov
- Published
- 2022
33. Measurement and QCD analysis of double-differential inclusive jet cross sections in proton-proton collisions at root s=13 TeV
- Author
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Tumasyan, A. Adam, W. Andrejkovic, J. W. Bergauer, T. and Chatterjee, S. Damanakis, K. Dragicevic, M. Escalante Del Valle, A. Fruhwirth, R. Jeitler, M. Krammer, N. Lechner, L. Liko, D. Mikulec, I. Paulitsch, P. Pitters, F. M. and Schieck, J. Schofbeck, R. Schwarz, D. Templ, S. and Waltenberger, W. Wulz, C. -E. Chekhovsky, V. Litomin, A. and Makarenko, V. Darwish, M. R. De Wolf, E. A. Janssen, T. and Kello, T. Lelek, A. Rejeb Sfar, H. Van Mechelen, P. Van Putte, S. Van Remortel, N. Blekman, F. Bols, E. S. and D'Hondt, J. Delcourt, M. El Faham, H. Lowette, S. and Moortgat, S. Morton, A. Muller, D. Sahasransu, A. R. and Tavernier, S. Van Doninck, W. Beghin, D. Bilin, B. and Clerbaux, B. De Lentdecker, G. Favart, L. Grebenyuk, A. and Kalsi, A. K. Lee, K. Mahdavikhorrami, M. Makarenko, I. and Moureaux, L. Petre, L. Popov, A. Postiau, N. Starling, E. Thomas, L. Vanden Bemden, M. Vander Velde, C. and Vanlaer, P. Cornelis, T. Dobur, D. Knolle, J. Lambrecht, L. Mestdach, G. Niedziela, M. Roskas, C. Samalan, A. and Skovpen, K. Tytgat, M. Vermassen, B. Wezenbeek, L. and Benecke, A. Bethani, A. Bruno, G. Bury, F. Caputo, C. and David, P. Delaere, C. Donertas, I. S. Giammanco, A. and Jaffel, K. Jain, Sa. Lemaitre, V. Mondal, K. and Prisciandaro, J. Taliercio, A. Teklishyn, M. Tran, T. T. and Vischia, P. Wertz, S. Alves, G. A. Hensel, C. Moraes, A. and Alda Junior, W. L. Alves Gallo Pereira, M. Barroso Ferreira Filho, M. Brandao Malbouisson, H. Carvalho, W. Chinellato, J. Da Costa, E. M. Da Silveira, G. G. De Jesus Damiao, D. and Fonseca De Souza, S. Mora Herrera, C. Mota Amarilo, K. and Mundim, L. Nogima, H. Rebello Teles, P. Santoro, A. and Silva Do Amaral, S. M. Sznajder, A. Thiel, M. Torres Da Silva De Araujo, F. Vilela Pereira, A. Bernardes, C. A. and Calligaris, L. Fernandez Perez Tomei, T. R. Gregores, E. M. and Lemos, D. S. Mercadante, P. G. Novaes, S. F. Padula, Sandra S. Aleksandrov, A. Antchev, G. Hadjiiska, R. Iaydjiev, P. Misheva, M. Rodozov, M. Shopova, M. Sultanov, G. and Dimitrov, A. Ivanov, T. Litov, L. Pavlov, B. Petkov, P. and Petrov, A. Cheng, T. Javaid, T. Mittal, M. Yuan, L. and Ahmad, M. Bauer, G. Dozen, C. Hu, Z. Martins, J. and Wang, Y. Yi, K. Chapon, E. Chen, G. M. Chen, H. S. and Chen, M. Iemmi, F. Kapoor, A. Leggat, D. Liao, H. and Liu, Z. -A. Milosevic, V. Monti, F. Sharma, R. Tao, J. and Thomas-Wilsker, J. Wang, J. Zhang, H. Zhao, J. and Agapitos, A. An, Y. Ban, Y. Chen, C. Levin, A. Li, Q. Lyu, X. Mao, Y. Qian, S. J. Wang, D. Wang, Q. and Xiao, J. Lu, M. You, Z. Gao, X. Okawa, H. Zhang, Y. and Lin, Z. Xiao, M. Avila, C. Cabrera, A. Florez, C. and Fraga, J. Mejia Guisao, J. Ramirez, F. Ruiz Alvarez, J. D. Salazar Gonzalez, C. A. Giljanovic, D. Godinovic, N. and Lelas, D. Puljak, I. Antunovic, Z. Kovac, M. Sculac, T. and Brigljevic, V. Ferencek, D. Majumder, D. Roguljic, M. and Starodumov, A. Susa, T. Attikis, A. Christoforou, K. and Erodotou, E. Ioannou, A. Kole, G. Kolosova, M. and Konstantinou, S. Mousa, J. Nicolaou, C. Ptochos, F. and Razis, P. A. Rykaczewski, H. Saka, H. Finger, M. Finger, Jr., M. Kveton, A. Ayala, E. Carrera Jarrin, E. Assran, Y. Ellithi Kamel, A. Mahmoud, M. A. Mohammed, Y. and Bhowmik, S. Dewanjee, R. K. Ehataht, K. Kadastik, M. and Nandan, S. Nielsen, C. Pata, J. Raidal, M. Tani, L. and Veelken, C. Eerola, P. Forthomme, L. Kirschenmann, H. and Osterberg, K. Voutilainen, M. Bharthuar, S. Brucken, E. and Garcia, F. Havukainen, J. Kim, M. S. Kinnunen, R. and Lampen, T. Lassila-Perini, K. Lehti, S. Linden, T. and Lotti, M. Martikainen, L. Myllymaki, M. Ott, J. and Siikonen, H. Tuominen, E. Tuominiemi, J. Luukka, P. and Petrow, H. Tuuva, T. Amendola, C. Besancon, M. Couderc, F. Dejardin, M. Denegri, D. Faure, J. L. Ferri, F. and Ganjour, S. Gras, P. Hamel de Monchenault, G. Jarry, P. and Lenzi, B. Locci, E. Malcles, J. Rander, J. Rosowsky, A. and Sahin, M. O. Savoy-Navarro, A. Titov, M. Yu, G. B. and Ahuja, S. Beaudette, F. Bonanomi, M. Buchot Perraguin, A. and Busson, P. Cappati, A. Charlot, C. Davignon, O. and Diab, B. Falmagne, G. Ghosh, S. Granier de Cassagnac, R. and Hakimi, A. Kucher, I. Motta, J. Nguyen, M. Ochando, C. and Paganini, P. Rembser, J. Salerno, R. Sarkar, U. and Sauvan, J. B. Sirois, Y. Tarabini, A. Zabi, A. Zghiche, A. Agram, J. -L. Andrea, J. Apparu, D. Bloch, D. and Bourgatte, G. Brom, J. -M. Chabert, E. C. Collard, C. and Darej, D. Fontaine, J. -C. Goerlach, U. Grimault, C. Le Bihan, A. -C. Nibigira, E. Van Hove, P. Asilar, E. and Beauceron, S. Bernet, C. Boudoul, G. Camen, C. Carle, A. and Chanon, N. Contardo, D. Depasse, P. El Mamouni, H. and Fay, J. Gascon, S. Gouzevitch, M. Ille, B. Laktineh, I. B. Lattaud, H. Lesauvage, A. Lethuillier, M. Mirabito, L. Perries, S. Shchablo, K. Sordini, V. Torterotot, L. and Touquet, G. Vander Donckt, M. Viret, S. Lomidze, I. and Toriashvili, T. Tsamalaidze, Z. Botta, V. Feld, L. and Klein, K. Lipinski, M. Meuser, D. Pauls, A. Rowert, N. and Schulz, J. Teroerde, M. Dodonova, A. Eliseev, D. and Erdmann, M. Fackeldey, P. Fischer, B. Ghosh, S. and Hebbeker, T. Hoepfner, K. Ivone, F. Mastrolorenzo, L. and Merschmeyer, M. Meyer, A. Mocellin, G. Mondal, S. and Mukherjee, S. Noll, D. Novak, A. Pook, T. Pozdnyakov, A. and Rath, Y. Reithler, H. Roemer, J. Schmidt, A. and Schuler, S. C. Sharma, A. Vigilante, L. Wiedenbeck, S. and Zaleski, S. Dziwok, C. Flugge, G. Haj Ahmad, W. and Hlushchenko, O. Kress, T. Nowack, A. Pistone, C. Pooth, O. Roy, D. Sert, H. Stahl, A. Ziemons, T. Zotz, A. and Aarup Petersen, H. Aldaya Martin, M. Asmuss, P. Baxter, S. Bayatmakou, M. Behnke, O. Bermudez Martinez, A. and Bhattacharya, S. Bin Anuar, A. A. Borras, K. Brunner, D. and Campbell, A. Cardini, A. Cheng, C. Colombina, F. and Consuegra Rodriguez, S. Correia Silva, G. Danilov, V. De Silva, M. Didukh, L. Eckerlin, G. Eckstein, D. Eren, E. and Estevez Banos, L. I. Filatov, O. Gallo, E. Gao, J. and Geiser, A. Giraldi, A. Grohsjean, A. Guthoff, M. Jafari, A. Jomhari, N. Z. Jung, H. Kasem, A. Kasemann, M. and Kaveh, H. Kleinwort, C. Kruecker, D. Lange, W. Lidrych, J. Lipka, K. Lohmann, W. Maekelae, T. Mankel, R. and Melzer-Pellmann, I. -A. Mendizabal Morentin, M. Metwally, J. and Meyer, A. B. Meyer, M. Mnich, J. Mussgiller, A. Otarid, Y. Perez Adan, D. Pitzl, D. Raspereza, A. Ribeiro Lopes, B. Ruebenach, J. Saggio, A. Saibel, A. Savitskyi, M. and Scham, M. Scheurer, V. Schnake, S. Schuetze, P. and Schwanenberger, C. Shchedrolosiev, M. Sosa Ricardo, R. E. and Stafford, D. Tonon, N. Van De Klundert, M. Walsh, R. and Walter, D. Wen, Y. Wichmann, K. Wiens, L. Wissing, C. and Wuchterl, S. Zlebcik, R. Aggleton, R. Albrecht, S. and Bein, S. Benato, L. Connor, P. De Leo, K. Eich, M. and Feindt, F. Froehlich, A. Garbers, C. Garutti, E. and Gunnellini, P. Hajheidari, M. Haller, J. Hinzmann, A. and Kasieczka, G. Klanner, R. Kogler, R. Kramer, T. Kutzner, V. Lange, J. Lange, T. Lobanov, A. Malara, A. and Nigamova, A. Pena Rodriguez, K. J. Rieger, O. Schleper, P. and Schroeder, M. Schwandt, J. Sonneveld, J. Stadie, H. and Steinbrueck, G. Tews, A. Zoi, I. Bechtel, J. Brommer, S. and Burkart, M. Butz, E. Caspart, R. Chwalek, T. De Boer, W. Dierlamm, A. Droll, A. El Morabit, K. and Faltermann, N. Giffels, M. Gosewisch, J. o. Gottmann, A. and Hartmann, F. Heidecker, C. Husemann, U. Keicher, P. and Koppenhoefer, R. Maier, S. Metzler, M. Mitra, S. and Mueller, Th. Neukum, M. Nuernberg, A. Quast, G. and Rabbertz, K. Rauser, J. Savoiu, D. Schnepf, M. Seith, D. and Shvetsov, I. Simonis, H. J. Ulrich, R. Van Der Linden, J. Von Cube, R. F. Wassmer, M. Weber, M. Wieland, S. and Wolf, R. Wozniewski, S. Wunsch, S. Anagnostou, G. and Daskalakis, G. Geralis, T. Kyriakis, A. Loukas, D. and Stakia, A. Diamantopoulou, M. Karasavvas, D. Karathanasis, G. Kontaxakis, P. Koraka, C. K. Manousakis-Katsikakis, A. and Panagiotou, A. Papavergou, I. Saoulidou, N. Theofilatos, K. Tziaferi, E. Vellidis, K. Vourliotis, E. Bakas, G. and Kousouris, K. Papakrivopoulos, I. Tsipolitis, G. and Zacharopoulou, A. Adamidis, K. Bestintzanos, I. Evangelou, I. Foudas, C. Gianneios, P. Katsoulis, P. Kokkas, P. and Manthos, N. Papadopoulos, I. Strologas, J. Csanad, M. and Farkas, K. Gadallah, M. M. A. Lokos, S. Major, P. and Mandal, K. Mehta, A. Pasztor, G. Radl, A. J. Suranyi, O. and Veres, G. I. Bartok, M. Bencze, G. Hajdu, C. and Horvath, D. Sikler, F. Veszpremi, V. Czellar, S. and Karancsi, J. Molnar, J. Szillasi, Z. Teyssier, D. Raics, P. Trocsanyi, Z. L. Ujvari, B. Csorgo, T. Nemes, F. and Novak, T. Choudhury, S. Komaragiri, J. R. Kumar, D. and Panwar, L. Tiwari, P. C. Bahinipati, S. Kar, C. Mal, P. and Mishra, T. Muraleedharan Nair Bindhu, V. K. Nayak, A. and Saha, P. Sur, N. Swain, S. K. Vats, D. Bansal, S. and Beri, S. B. Bhatnagar, V. Chaudhary, G. Chauhan, S. and Dhingra, N. Gupta, R. Kaur, A. Kaur, M. Kaur, S. and Kumari, P. Meena, M. Sandeep, K. Singh, J. B. Virdi, A. K. Ahmed, A. Bhardwaj, A. Choudhary, B. C. Gola, M. and Keshri, S. Kumar, A. Naimuddin, M. Priyanka, P. Ranjan, K. Shah, A. Bharti, M. Bhattacharya, R. Bhattacharya, S. and Bhowmik, D. Dutta, S. Dutta, S. Gomber, B. Maity, M. and Palit, P. Rout, P. K. Saha, G. Sahu, B. Sarkar, S. and Sharan, M. Singh, B. Thakur, S. Behera, P. K. and Behera, S. C. Kalbhor, P. Muhammad, A. Pradhan, R. and Pujahari, P. R. Sharma, A. Sikdar, A. K. Dutta, D. Jha, V. Kumar, V. Mishra, D. K. Naskar, K. Netrakanti, P. K. and Pant, L. M. Shukla, P. Aziz, T. Dugad, S. Kumar, M. and Banerjee, S. Chudasama, R. Guchait, M. Karmakar, S. and Kumar, S. Majumder, G. Mazumdar, K. Mukherjee, S. and Alpana, K. Dube, S. Kansal, B. Laha, A. Pandey, S. and Rane, A. Rastogi, A. Sharma, S. Bakhshiansohi, H. and Khazaie, E. Zeinali, M. Chenarani, S. Etesami, S. M. and Khakzad, M. Mohammadi Najafabadi, M. Grunewald, M. and Abbrescia, M. Aly, R. Aruta, C. Colaleo, A. Creanza, D. and De Filippis, N. De Palma, M. Di Florio, A. Di Pilato, A. and Elmetenawee, W. Fiore, L. Gelmi, A. Gul, M. Iaselli, G. Ince, M. Lezki, S. Maggi, G. Maggi, M. Margjeka, I. Mastrapasqua, V. My, S. Nuzzo, S. Pellecchia, A. and Pompili, A. Pugliese, G. Ramos, D. Ranieri, A. Selvaggi, G. Silvestris, L. Simone, F. M. Venditti, R. and Verwilligen, P. Abbiendi, G. Battilana, C. Bonacorsi, D. and Borgonovi, L. Brigliadori, L. Campanini, R. Capiluppi, P. and Castro, A. Cavallo, F. R. Cuffiani, M. Dallavalle, G. M. and Diotalevi, T. Fabbri, F. Fanfani, A. Giacomelli, P. and Giommi, L. Grandi, C. Guiducci, L. Lo Meo, S. Lunerti, L. Marcellini, S. Masetti, G. Navarria, F. L. Perrotta, A. Primavera, F. Rossi, A. M. Rovelli, T. Siroli, G. P. and Albergo, S. Costa, S. Di Mattia, A. Potenza, R. and Tricomi, A. Tuve, C. Barbagli, G. Cassese, A. and Ceccarelli, R. Ciulli, V. Civinini, C. D'Alessandro, R. and Focardi, E. Latino, G. Lenzi, P. Lizzo, M. Meschini, M. and Paoletti, S. Seidita, R. Sguazzoni, G. Viliani, L. and Benussi, L. Bianco, S. Piccolo, D. Bozzo, M. 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Kim, H. Luo, S. Malhotra, S. Mueller, R. Overton, D. Rathjens, D. Safonov, A. Akchurin, N. and Damgov, J. Hegde, V. Kunori, S. Lamichhane, K. Lee, S. W. Mengke, T. Muthumuni, S. Peltola, T. Volobouev, I. and Wang, Z. Whitbeck, A. Appelt, E. Greene, S. Gurrola, A. Johns, W. Melo, A. Ni, H. Padeken, K. Romeo, F. and Sheldon, P. Tuo, S. Velkovska, J. Arenton, M. W. and Cox, B. Cummings, G. Hakala, J. Hirosky, R. Joyce, M. and Ledovskoy, A. Li, A. Neu, C. Perez Lara, C. E. and Tannenwald, B. White, S. Wolfe, E. Poudyal, N. Black, K. and Bose, T. Caillol, C. Dasu, S. De Bruyn, I. and Everaerts, P. Fienga, F. Galloni, C. He, H. Herndon, M. and Herve, A. Hussain, U. Lanaro, A. Loeliger, A. and Loveless, R. Madhusudanan Sreekala, J. Mallampalli, A. and Mohammadi, A. Pinna, D. Savin, A. Shang, V. Sharma, V. and Smith, W. H. Teague, D. Trembath-Reichert, S. Vetens, W. and CMS Collaboration
- Subjects
High Energy Physics::Phenomenology ,High Energy Physics::Experiment - Abstract
A measurement of the inclusive jet production in proton-proton collisions at the LHC at root s = 13TeV is presented. The double-differential cross sections are measured as a function of the jet transverse momentum p(T) and the absolute jet rapidity vertical bar y vertical bar. The anti- k(T) clustering algorithm is used with distance parameter of 0.4 (0.7) in a phase space region with jet p(T) from 97 GeV up to 3.1TeV and vertical bar y vertical bar < 2.0. Data collected with the CMS detector are used, corresponding to an integrated luminosity of 36.3 fb(-1) (33.5 fb(-1)). The measurement is used in a comprehensive QCD analysis at next-to-next-to-leading order, which results in significant improvement in the accuracy of the parton distributions in the proton. Simultaneously, the value of the strong coupling constant at the Z boson mass is extracted as alpha(S)(m(Z)) = 0.1170 +/- 0.0019. For the first time, these data are used in a standard model effective field theory analysis at next-to-leading order, where parton distributions and the QCD parameters are extracted simultaneously with imposed constraints on the Wilson coefficient c(1) of 4-quark contact interactions.
- Published
- 2022
34. Measurement of W±γ differential cross sections in proton-proton collisions at s =13 TeV and effective field theory constraints
- Author
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Sexton-Kennedy, E. Smith, N. Soha, A. Spalding, W.J. Spiegel, L. Stoynev, S. Strait, J. Taylor, L. Tkaczyk, S. Tran, N.V. Uplegger, L. Vaandering, E.W. Weber, H.A. Acosta, D. Avery, P. Bourilkov, D. Cadamuro, L. Cherepanov, V. Errico, F. Field, R.D. Guerrero, D. Joshi, B.M. Kim, M. Koenig, E. Konigsberg, J. Korytov, A. Lo, K.H. Matchev, K. Menendez, N. Mitselmakher, G. Muthirakalayil Madhu, A. Rawal, N. Rosenzweig, D. Rosenzweig, S. Shi, K. Sturdy, J. Wang, J. Yigitbasi, E. Zuo, X. Adams, T. Askew, A. Habibullah, R. Hagopian, V. Johnson, K.F. Khurana, R. Kolberg, T. Martinez, G. Prosper, H. Schiber, C. Viazlo, O. Yohay, R. Zhang, J. Baarmand, M.M. Butalla, S. Elkafrawy, T. Hohlmann, M. Kumar Verma, R. Noonan, D. Rahmani, M. Yumiceva, F. Adams, M.R. Becerril Gonzalez, H. Cavanaugh, R. Chen, X. Dittmer, S. Evdokimov, O. Gerber, C.E. Hangal, D.A. Hofman, D.J. Merrit, A.H. Mills, C. Oh, G. Roy, T. Rudrabhatla, S. Tonjes, M.B. Varelas, N. Viinikainen, J. Wang, X. Wu, Z. Ye, Z. Alhusseini, M. Dilsiz, K. Gandrajula, R.P. Köseyan, O.K. Merlo, J.-P. Mestvirishvili, A. Nachtman, J. Ogul, H. Onel, Y. Penzo, A. Snyder, C. Tiras, E. Amram, O. Blumenfeld, B. Corcodilos, L. Davis, J. Eminizer, M. Gritsan, A.V. Kyriacou, S. Maksimovic, P. Roskes, J. Swartz, M. Vámi, T.Á. Abreu, A. Anguiano, J. Baldenegro Barrera, C. Baringer, P. Bean, A. Bylinkin, A. Flowers, Z. Isidori, T. Khalil, S. King, J. Krintiras, G. Kropivnitskaya, A. Lazarovits, M. Lindsey, C. Marquez, J. Minafra, N. Murray, M. Nickel, M. Rogan, C. Royon, C. Salvatico, R. Sanders, S. Schmitz, E. Smith, C. Tapia Takaki, J.D. Wang, Q. Warner, Z. Williams, J. Wilson, G. Duric, S. Ivanov, A. Kaadze, K. Kim, D. Maravin, Y. Mitchell, T. Modak, A. Nam, K. Rebassoo, F. Wright, D. Adams, E. Baden, A. Baron, O. Belloni, A. Eno, S.C. Hadley, N.J. Jabeen, S. Kellogg, R.G. Koeth, T. Mignerey, A.C. Nabili, S. Seidel, M. Skuja, A. Wang, L. Wong, K. Abercrombie, D. Andreassi, G. Bi, R. Brandt, S. Busza, W. Cali, I.A. Chen, Y. D'Alfonso, M. Eysermans, J. Freer, C. Gomez Ceballos, G. Goncharov, M. Harris, P. Hu, M. Klute, M. Kovalskyi, D. Krupa, J. Lee, Y.-J. Maier, B. Mironov, C. Paus, C. Rankin, D. Roland, C. Roland, G. Shi, Z. Stephans, G.S.F. Tatar, K. Wang, J. Wang, Z. Wyslouch, B. Chatterjee, R.M. Evans, A. Hansen, P. Hiltbrand, J. Jain, S. Krohn, M. Kubota, Y. Mans, J. Revering, M. Rusack, R. Saradhy, R. Schroeder, N. Strobbe, N. Wadud, M.A. Bloom, K. Bryson, M. Chauhan, S. Claes, D.R. Fangmeier, C. Finco, L. Golf, F. Joo, C. Kravchenko, I. Musich, M. Reed, I. Siado, J.E. Snow, G.R. Tabb, W. Yan, F. Agarwal, G. Bandyopadhyay, H. Hay, L. Iashvili, I. Kharchilava, A. McLean, C. Nguyen, D. Pekkanen, J. Rappoccio, S. Williams, A. Alverson, G. Barberis, E. Haddad, Y. Hortiangtham, A. Li, J. Madigan, G. Marzocchi, B. Morse, D.M. Nguyen, V. Orimoto, T. Parker, A. Skinnari, L. Tishelman-Charny, A. Wamorkar, T. Wang, B. Wisecarver, A. Wood, D. Bhattacharya, S. Bueghly, J. Chen, Z. Gilbert, A. Gunter, T. Hahn, K.A. Liu, Y. Odell, N. Schmitt, M.H. Velasco, M. Band, R. Bucci, R. Das, A. Dev, N. Goldouzian, R. Hildreth, M. Hurtado Anampa, K. Jessop, C. Lannon, K. Lawrence, J. Loukas, N. Lutton, D. Marinelli, N. McAlister, I. McCauley, T. Meng, F. Mohrman, K. Musienko, Y. Ruchti, R. Siddireddy, P. Townsend, A. Wayne, M. Wightman, A. Wolf, M. Zarucki, M. Zygala, L. Bylsma, B. Cardwell, B. Durkin, L.S. Francis, B. Hill, C. Nunez Ornelas, M. Wei, K. Winer, B.L. Yates, B.R. Addesa, F.M. Bonham, B. Das, P. Dezoort, G. Elmer, P. Frankenthal, A. Greenberg, B. Haubrich, N. Higginbotham, S. Kalogeropoulos, A. Kopp, G. Kwan, S. Lange, D. Lucchini, M.T. Marlow, D. Mei, K. Ojalvo, I. Olsen, J. Palmer, C. Stickland, D. Tully, C. Malik, S. Norberg, S. Bakshi, A.S. Barnes, V.E. Chawla, R. Das, S. Gutay, L. Jones, M. Jung, A.W. Karmarkar, S. Liu, M. Negro, G. Neumeister, N. Paspalaki, G. Peng, C.C. Piperov, S. Purohit, A. Schulte, J.F. Stojanovic, M. Thieman, J. Wang, F. Xiao, R. Xie, W. Dolen, J. Parashar, N. Baty, A. Decaro, M. Dildick, S. Ecklund, K.M. Freed, S. Gardner, P. Geurts, F.J.M. Kumar, A. Li, W. Padley, B.P. Redjimi, R. Shi, W. Stahl Leiton, A.G. Yang, S. Zhang, L. Zhang, Y. Bodek, A. De Barbaro, P. Demina, R. Dulemba, J.L. Fallon, C. Ferbel, T. Galanti, M. Garcia-Bellido, A. Hindrichs, O. Khukhunaishvili, A. Ranken, E. Taus, R. Chiarito, B. Chou, J.P. Gandrakota, A. Gershtein, Y. Halkiadakis, E. Hart, A. Heindl, M. Karacheban, O. Laflotte, I. Lath, A. Montalvo, R. Nash, K. Osherson, M. Salur, S. Schnetzer, S. Somalwar, S. Stone, R. Thayil, S.A. Thomas, S. Wang, H. Acharya, H. Delannoy, A.G. Spanier, S. Bouhali, O. Dalchenko, M. Delgado, A. Eusebi, R. Gilmore, J. Huang, T. Kamon, T. Kim, H. Luo, S. Malhotra, S. Mueller, R. Overton, D. Rathjens, D. Safonov, A. Akchurin, N. Damgov, J. Hegde, V. Kunori, S. Lamichhane, K. Lee, S.W. Mengke, T. Muthumuni, S. Peltola, T. Volobouev, I. Wang, Z. Whitbeck, A. Appelt, E. Greene, S. Gurrola, A. Johns, W. Melo, A. Ni, H. Padeken, K. Romeo, F. Sheldon, P. Tuo, S. Velkovska, J. Arenton, M.W. Cox, B. Cummings, G. Hakala, J. Hirosky, R. Joyce, M. Ledovskoy, A. Li, A. Neu, C. Tannenwald, B. White, S. Wolfe, E. Poudyal, N. Black, K. Bose, T. Buchanan, J. Caillol, C. Dasu, S. De Bruyn, I. Everaerts, P. Fienga, F. Galloni, C. He, H. Herndon, M. Hervé, A. Hussain, U. Lanaro, A. Loeliger, A. Loveless, R. Madhusudanan Sreekala, J. Mallampalli, A. Mohammadi, A. Pinna, D. Savin, A. Shang, V. Sharma, V. Smith, W.H. Teague, D. Trembath-Reichert, S. Vetens, W. (CMS Collaboration)
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High Energy Physics::Experiment ,Nuclear Experiment - Abstract
Differential cross section measurements of W±γ production in proton-proton collisions at s=13 TeV are presented. The data set used in this study was collected with the CMS detector at the CERN LHC in 2016-2018 with an integrated luminosity of 138 fb-1. Candidate events containing an electron or muon, a photon, and missing transverse momentum are selected. The measurements are compared with standard model predictions computed at next-to-leading and next-to-next-to-leading orders in perturbative quantum chromodynamics. Constraints on the presence of TeV-scale new physics affecting the WWγ vertex are determined within an effective field theory framework, focusing on the O3W operator. A simultaneous measurement of the photon transverse momentum and the azimuthal angle of the charged lepton in a special reference frame is performed. This two-dimensional approach provides up to a factor of ten more sensitivity to the interference between the standard model and the O3W contribution than using the transverse momentum alone. © 2022 CERN.
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- 2022
35. Xinjiangchelyid turtles from the Middle Jurassic of the Berezovsk coal mine (Krasnoyarsk Territory, Russia): systematics, skeletal morphology, variation, relationships and palaeobiogeographic implications
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Ekaterina M. Obraztsova, Sergei A. Krasnolutskii, Vladimir B. Sukhanov, and Igor G. Danilov
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Paleontology - Abstract
This paper is devoted to the description of a new species of xinjiangchelyid turtle – Annemys variabilis sp. nov. – represented by thousands of isolated bones and several more complete specimens from the Middle Jurassic (Bathonian) Itat Formation of the Berezovsk coal mine, Krasnoyarsk Territory, western Siberia, Russia. The description is based on a sample of the best-preserved specimens. The new species differs from other Annemys spp. by a combination of cranial and shell characters. The basisphenoids (about 200 specimens) of A. variabilis demonstrate variation in 12 characters, some of which are reported in turtles for the first time. About 20 shell characters of A. variabilis are subject to ontogenetic or interindividual variation. Some of these characters are variable in other Annemys spp. and other xinjiangchelyids. The formula of the cervical vertebrae [(2(3()4()5()6()7()8) or (2(3()4()5()6()7()8(] with two opisthocoelous vertebrae (2 and 3), four or five amphicoelous vertebrae (4–7 or 4–8), and one procoelous vertebra is unique for this species among xinjiangchelyids, which were previously known to have only amphicoelous cervicals. Other characters of the non-shell postcranium correspond to those of other xinjiangchelyids. Of the three phylogenetic analyses performed in this study, Analysis 1 does not support the monophyly of either Xinjiangchelyidae or Annemys, Analysis 2 shows paraphyly of Xinjiangchelyidae and monophyly of the Annemys clade (A. latiens, A. levensis, A. variabilis and A. wusu), and Analysis 3 supports monophyly of the Annemys clade with A. latiens, A. levensis and A. variabilis, only in the majority rule consensus tree. The diversity of the turtle assemblage of the Itat Formation is re-assessed as containing 2–3 taxa (A. variabilis [=Testudines indet. 2], Testudines indet. 1 and 3), which is in agreement with similar diversities seen in some other Middle Jurassic Asian turtle assemblages. The known record of Annemys spp. is restricted to the northern part of Asia. https://zoobank.org/urn:lsid:zoobank.org:pub:E836F02F-21DD-4A36-ACBB-4170A6CD46AD
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- 2022
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36. De novo transcriptome assembly and annotation of parthenogenetic lizard Darevskia unisexualis and its parental ancestors Darevskia valentini and Darevskia raddei nairensis
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Sergei S. Ryakhovsky, Victoria A. Dikaya, Vitaly I. Korchagin, Andrey A. Vergun, Lavrentii G. Danilov, Sofia D. Ochkalova, Anastasiya E. Girnyk, Daria V. Zhernakova, Marine S. Arakelyan, Vladimir B. Brukhin, Aleksey S. Komissarov, and Alexey P. Ryskov
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Ovaries ,Q1-390 ,Multidisciplinary ,Science (General) ,Darevskia lizards ,Computer applications to medicine. Medical informatics ,Parthenogenesis ,R858-859.7 ,Transcriptome analysis ,Data Article ,AMP - Abstract
Darevskia rock lizards include 29 sexual and seven parthenogenetic species of hybrid origin distributed in the Caucasus. All seven parthenogenetic species of the genus Darevskia were formed as a result of interspecific hybridization of only four sexual species. It remains unknown what are the main advantages of interspecific hybridization along with switching on parthenogenetic reproduction in evolution of reptiles. Data on whole transcriptome sequencing of parthenogens and their parental ancestors can provide value impact in solving this problem. Here we have sequenced ovary tissue transcriptomes from unisexual parthenogenetic lizard D. unisexualis and its parental bisexual ancestors to facilitate the subsequent annotation and to obtain the collinear characteristics for comparison with other lizard species. Here we report generated RNAseq data from total mRNA of ovary tissues of D. unisexualis, D. valentini and D. raddei with 58932755, 51634041 and 62788216 reads. Obtained RNA reads were assembled by Trinity assembler and 95141, 62123, 61836 contigs were identified with N50 values of 2409, 2801 and 2827 respectively. For further analysis top Gene Ontology terms were annotated for all species and transcript number was calculated. The raw data were deposited in the NCBI SRA database (BioProject PRJNA773939). The assemblies are available in Mendeley Data and can be accessed via doi:10.17632/rtd8cx7zc3.1.
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- 2021
37. Remarks on vacuum state and uniqueness of concentration process
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Vladimir G. Danilov
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Zero-pressure gas dynamics system ,vacuum state ,delta-shock solution ,Mathematics ,QA1-939 - Abstract
We give two examples of nonuniqueness of generalized solutions of pressureless gas dynamics systems. In both of these examples, the presence of the Dirac delta-function leads to nonuniqueness.
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- 2008
38. The Human NUP58 Nucleoporin Can Form Amyloids In Vitro and In Vivo
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Xenia V. Sukhanova, Andrew G. Matveenko, Stanislav A. Bondarev, S. E. Moskalenko, Lavrentii G. Danilov, Galina A. Zhouravleva, and Mikhail V. Belousov
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Amyloid ,C-DAG ,QH301-705.5 ,medicine.medical_treatment ,Medicine (miscellaneous) ,Protein aggregation ,General Biochemistry, Genetics and Molecular Biology ,Article ,protein aggregation ,chemistry.chemical_compound ,nucleoporins ,In vivo ,mental disorders ,evolution ,medicine ,Biology (General) ,ArchCandy ,Protease ,Chemistry ,Congo Red ,human amyloids ,Yeast ,In vitro ,Congo red ,Biophysics ,Nucleoporin - Abstract
Amyloids are fibrillar protein aggregates with a cross-β structure and unusual features, including high resistance to detergent or protease treatment. More than two hundred different proteins with amyloid or amyloid-like properties are already known. Several examples of nucleoporins (e.g., yeast Nup49, Nup100, Nup116, and human NUP153) are supposed to form amyloid fibrils. In this study, we demonstrated an ability of the human NUP58 nucleoporin to form amyloid aggregates in vivo and in vitro. Moreover, we found two forms of NUP58 aggregates: oligomers and polymers stabilized by disulfide bonds. Bioinformatic analysis revealed that all known orthologs of this protein are potential amyloids which possess several regions with conserved ability to aggregation. The biological role of nucleoporin amyloid formation is debatable. We suggest that it is a rather abnormal process, which is characteristic for many proteins implicated in phase separation.
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- 2021
39. Species-Specific Proteins in the Oviducts of Snail Sibling Species: Proteotranscriptomic Study of Littorina fabalis and L. obtusata
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Irina Y. Babkina, Alexander V. Predeus, Arseniy A. Lobov, Lavrentii G. Danilov, Alexey E. Masharskiy, Arina L. Maltseva, Natalia Mikhailova, and Andrei I. Granovitch
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General Immunology and Microbiology ,biology ,QH301-705.5 ,Littorina fabalis ,Littorina ,Snail ,Gel electrophoresis of proteins ,biology.organism_classification ,General Biochemistry, Genetics and Molecular Biology ,sibling species ,Evolutionary biology ,biology.animal ,Littorina obtusata ,Reproductive system ,invertebrate reproduction ,Subgenus ,RNA-seq ,Biology (General) ,General Agricultural and Biological Sciences ,Mollusca ,mollusca ,2D DIGE - Abstract
Genus Littorina subgenus Neritrema (Mollusca, Caenogastropoda) includes the “obtusata” group of closely related species (Littorina obtusata and L. fabalis). The anatomy of the adult reproductive system (pallial oviduct) is the only reliable feature used for species identification in females of these species. Reproductive system anatomy and reproduction-associated proteins often diverge between sibling species. Despite being of high evolutionary interest, the molecular basis of this divergence remains poorly understood. We performed proteotranscriptomic comparison of oviducts of L. obtusata and L. fabalis by RNA-seq on Illumina HiSeq 2500 and two-dimensional protein electrophoresis (2D DIGE) with MS/MS identification of the species-specific proteins. The interspecies differences in the oviduct were associated with (1) metabolic proteins reflecting overall physiological differences between L. obtusata and L. fabalis, (2) receptor proteins, and (3) transcripts related to transposable elements (TEs). Various receptors identified may recognize a wide variety of ligands from pathogen-associated molecular patterns to specific carbohydrates on the sperm surface. Therefore, these may participate in immune defense as well as in sperm storage and regulation. Species-specificity of multiple TE sequences (coding for reverse transcriptase and ribonuclease H) may indicate the important role of these genomic elements in the Littorina species divergence, which has not been reported previously.
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- 2021
40. Species-Specific Proteins in the Oviducts of Snail Sibling Species: Proteotranscriptomic Study of
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Arseniy A, Lobov, Irina Y, Babkina, Lavrentii G, Danilov, Alexey E, Masharskiy, Alexander V, Predeus, Natalia A, Mikhailova, Andrei I, Granovitch, and Arina L, Maltseva
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sibling species ,Littorina ,invertebrate reproduction ,RNA-seq ,Article ,mollusca ,2D DIGE - Abstract
Simple Summary Genitalia and reproduction-associated proteins are often species-specific and might evolve rapidly. The situation in which the morphology of the reproductive system is the only difference between two or several closely related species has been reported on multiple occasions. Nevertheless, the reasons for such rapid divergence of the reproductive system is still poorly investigated. To shed some light on the issue, we performed a transcriptomic and proteomic comparison of pallial oviducts from the two sibling species of gastropods Littorina obtusata and L. fabalis. The main identified differences were associated with three functional groups of genes: transposable elements, which enhance genome variation and promote the evolution of new genes, receptor proteins potentially involved in friend or foe recognition, and various enzymes. We hypothesize that these functional groups reflect both the mechanism (transposable elements) and the directions (friend or foe recognition and reproductive physiology) of the rapid evolution of the reproductive system. Abstract Genus Littorina subgenus Neritrema (Mollusca, Caenogastropoda) includes the “obtusata” group of closely related species (Littorina obtusata and L. fabalis). The anatomy of the adult reproductive system (pallial oviduct) is the only reliable feature used for species identification in females of these species. Reproductive system anatomy and reproduction-associated proteins often diverge between sibling species. Despite being of high evolutionary interest, the molecular basis of this divergence remains poorly understood. We performed proteotranscriptomic comparison of oviducts of L. obtusata and L. fabalis by RNA-seq on Illumina HiSeq 2500 and two-dimensional protein electrophoresis (2D DIGE) with MS/MS identification of the species-specific proteins. The interspecies differences in the oviduct were associated with (1) metabolic proteins reflecting overall physiological differences between L. obtusata and L. fabalis, (2) receptor proteins, and (3) transcripts related to transposable elements (TEs). Various receptors identified may recognize a wide variety of ligands from pathogen-associated molecular patterns to specific carbohydrates on the sperm surface. Therefore, these may participate in immune defense as well as in sperm storage and regulation. Species-specificity of multiple TE sequences (coding for reverse transcriptase and ribonuclease H) may indicate the important role of these genomic elements in the Littorina species divergence, which has not been reported previously.
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- 2021
41. Clinical and Genetic Characteristics of Pediatric Patients with Hypophosphatasia in the Russian Population
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Oleg S. Glotov, Kirill V. Savostyanov, Tatyana S. Nagornova, Alexandr N. Chernov, Mikhail A. Fedyakov, Aleksandra N. Raspopova, Konstantin N. Krasnoukhov, Lavrentii G. Danilov, Nadegda V. Moiseeva, Roman S. Kalinin, Victoria V. Tsai, Yuri A. Eismont, Victoria Y. Voinova, Alisa V. Vitebskaya, Elena Y. Gurkina, Ludmila M. Kuzenkova, Irina B. Sosnina, Alexander A. Pushkov, Ilya S. Zhanin, and Ekaterina Y. Zakharova
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Heterozygote ,Organic Chemistry ,Hypophosphatasia ,General Medicine ,Alkaline Phosphatase ,Catalysis ,Computer Science Applications ,Inorganic Chemistry ,Mutation ,Humans ,hypophosphatasia ,clinical forms of hypophosphatasia ,tissue-specific alkaline phosphatase ,ALPL gene ,SNP ,residual activity of ALPL mutant alleles ,Physical and Theoretical Chemistry ,Child ,Molecular Biology ,Spectroscopy - Abstract
(1) Hypophosphatasia (HPP) is a rare inherited disease caused by mutations (pathogenic variants) in the ALPL gene which encodes tissue-nonspecific alkaline phosphatase (TNSALP). HPP is characterized by impaired bone mineral metabolism due to the low enzymatic activity of TNSALP. Knowledge about the structure of the gene and the features and functions of various ALPL gene variants, taking into account population specificity, gives an understanding of the hereditary nature of the disease, and contributes to the diagnosis, prevention, and treatment of the disease. The purpose of the study was to describe the spectrum and analyze the functional features of the ALPL gene variants, considering various HPP subtypes and clinical symptoms in Russian children. (2) From 2014–2021, the study included the blood samples obtained from 1612 patients with reduced alkaline phosphatase activity. The patients underwent an examination with an assessment of their clinical symptoms and biochemical levels of TNSALP. DNA was isolated from dried blood spots (DBSs) or blood from the patients to search for mutations in the exons of the ALPL gene using Sanger sequencing. The PCR products were sequenced using a reagent BigDye Terminator 3.1 kit (Applied Biosystems). Statistical analysis was performed using the GraphPad Prism 8.01 software. (3) The most common clinical symptoms in Russian patients with HPP and two of its variants (n = 22) were bone disorders (75%), hypomyotonia (50%), and respiratory failure (50%). The heterozygous carriage of the causal variants of the ALPL gene was detected in 225 patients. A total of 2 variants were found in 27 patients. In this group (n = 27), we identified 28 unique variants of the ALPL gene, of which 75.0% were missense, 17.9% were frameshift, 3.6% were splicing variants, and 3.6% were duplications. A total of 39.3% (11/28) of the variants were pathogenic, with two variants being probably pathogenic, and 15 variants had unknown clinical significance (VUS). Among the VUS group, 28.6% of the variants (7/28) were discovered by us for the first time. The most common variants were c.571G > A (p.Glu191Lys) and c.1171del (Arg391Valfs*12), with frequencies of 48.2% (13/28) and 11% (3/28), respectively. It was found that the frequency of nonsense variants of the ALPL gene was higher (p < 0.0001) in patients with the perinatal form compared to the infantile and childhood forms of HPP. Additionally, the number of homozygotes in patients with the perinatal form exceeded (p < 0.01) the frequencies of these genotypes in children with infantile and childhood forms of HPP. On the contrary, the frequencies of the compound-heterozygous and heterozygous genotypes were higher (p < 0.01) in patients with infantile childhood HPP than in perinatal HPP. In the perinatal form, residual TNSALP activity was lower (p < 0.0005) in comparison to the infantile and childhood (p < 0.05) forms of HPP. At the same time, patients with the heterozygous and compound-heterozygous genotypes (mainly missense variants) of the ALPL gene had greater residual activity (of the TNSALP protein) regarding those homozygous patients who were carriers of the nonsense variants (deletions and duplications) of the ALPL gene. Residual TNSALP activity was lower (p < 0.0001) in patients with pathogenic variants encoding the amino acids from the active site and the calcium and crown domains in comparison with the nonspecific region of the protein.
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- 2022
42. Weak asymptotic method for the study of propagation and interaction of infinitely narrow delta-solitons
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Vladimir G. Danilov and Georgii A. Omel'yanov
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KdV type equations ,soliton ,soliton interaction. ,Mathematics ,QA1-939 - Abstract
We present a new method for studying the interaction of solitons for non-integrable Korteweg-de Vries (KdV) type equations with small dispersion and test this method for the KdV equation.
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- 2003
43. Turtles Protestudo bessarabica from the Late Miocene of Ukraine
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Tatiana Krakhmalnaya, Igor G. Danilov, Elena V. Syromyatnikova, and V. M. Chkhikvadze
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Geographic distribution ,Paleontology ,law ,Biozone ,Late Miocene ,Turtle (robot) ,Geology ,law.invention - Abstract
The paper describes three incomplete shells of terrestrial turtle Protestudo bessarabica (Testudinidae) from the Late Miocene (Maeotian, biozone MN 12) of the Belka locality (Ukraine). This is the first description of this species from Ukraine. Materials from Belka add to the data on morphology and variation of the P. bessarabica shell in the formula of the neural plates, the shape of the precentral scale and the gular projection. Additionally, materials from Belka confirm the previously known variation of the shell of P. bessarabica in other characters. This species had a wide geographic distribution in Eastern Europe (Moldova, Russia, and Ukraine) in a rather narrow time interval of the Late Sarmatian–Maeotian and may be important for biostratigraphic correlation.
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- 2019
44. W.A. Lindholm’s contributions to herpetology with an annotated bibliography of his herpetological publications
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Igor G. Danilov
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0106 biological sciences ,Annotated bibliography ,Geography ,Insect Science ,010607 zoology ,Library science ,Animal Science and Zoology ,Herpetology ,Aquatic Science ,010603 evolutionary biology ,01 natural sciences ,Ecology, Evolution, Behavior and Systematics - Abstract
This paper presents notes on the herpetological biography of W.A. Lindholm (1874–1935), a Russian-Soviet zoologist known mostly by his contributions to malacology and herpetology. His 15 herpetological publications, which are annotated in this paper, include naturalistic observations of amphibians and reptiles, commentaries on the catalogue of reptiles and amphibians from the collection of the Museum Wiesbaden, descriptions of new taxa of lizards, snakes, and turtles, revision of the classification of Recent turtles and studies on the nomenclature of some amphibians and reptiles. This paper also contains a list of 21 reptilian taxa introduced by Lindholm and a list of four reptilian taxa named in honour of him.
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- 2019
45. A Sea Turtle (Cheloniidae) from the Middle Eocene of North Caucasus
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E. A. Zvonok, Igor G. Danilov, Alexandre F. Bannikov, and Elena V. Syromyatnikova
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0106 biological sciences ,010506 paleontology ,biology ,010607 zoology ,Paleontology ,Eochelone ,biology.organism_classification ,01 natural sciences ,Geographic distribution ,Geography ,Sea turtle ,Genus ,Cheloniidae ,Allopleuron ,0105 earth and related environmental sciences - Abstract
The incomplete skeleton of a juvenile sea turtle (Cheloniidae) is described from the terminal Bartonian (late Middle Eocene) of the Gorny Luch locality (Krasnodar krai, Russia) as Eochelone sp. The new find extends the known geographic distribution of turtles of the genus Eochelone Dollo, 1903, previously known in Europe only from the Lutetian of Belgium and Ukraine, the Bartonian of England and the Priabonian of Spain. In addition, the described specimen has common features with “Allopleuron” qazaqstanense Karl et al., 2012 from the Bartonian and, possibly, the Lutetian of Kazakhstan.
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- 2019
46. Interaction of δ-Shock Waves in a System of Pressureless Gas Dynamics Equations
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Vladimir G. Danilov
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Physics ,Shock wave ,Nonlinear system ,010102 general mathematics ,0103 physical sciences ,Statistical and Nonlinear Physics ,010307 mathematical physics ,Gas dynamics ,Mechanics ,0101 mathematics ,01 natural sciences ,Mathematical Physics - Abstract
In the present paper, an analytic description of nonlinear delta-shock waves interaction is described by using the weak asymptotics method.
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- 2019
47. Paleogene Turtles of Crimea
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Igor G. Danilov and E. A. Zvonok
- Subjects
0106 biological sciences ,Cosmochelys ,010506 paleontology ,biology ,Fauna ,010607 zoology ,Trionychidae ,Paleontology ,Zoology ,Argillochelys ,biology.organism_classification ,01 natural sciences ,law.invention ,Geography ,law ,Cheloniidae ,Dermochelyidae ,Turtle (robot) ,Paleogene ,0105 earth and related environmental sciences - Abstract
This paper describes remains of fossil turtles from five Paleogene localities of Crimea. Two are Danian (Ak-Kaya 2 and Sakharnaya Golovka) and three are Bartonian (Ak-Kaya 1, Bakhchisarai and Prolom). The best studied turtle fauna comes from the Ak-Kaya 1 locality and includes three taxa: marine Argillochelys sp. (Cheloniidae) and Cosmochelys sp. (Dermochelyidae), and an unidentified soft-shelled turtle (Trionychidae indet.). Argillochelys sp. shows similarities with Argillochelys antiqua (Konig, 1825) from the Eocene of Europe. The new data expands our knowledge of intraspecific variability and the distribution of turtles of the genera Argillochelys and Cosmochelys. Unidentified cheloniids (Bakhchisarai, Prolom, and Sakharnaya Golovka), dermochelyids (Bakhchisarai and Prolom) and trionychids (Ak-Kaya 2 and Prolom) are described from other Paleogene localities of Crimea.
- Published
- 2019
48. MONITORING AND MANAGING SOFTWARE FOR RECONFIGURABLE COMPUTING SYSTEMS BASED ON REST-ARCHITECTURE
- Author
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Z. V. Kalyaev, I. G. Danilov, and I. N. Eroshenko
- Subjects
Rest (physics) ,Software ,Computer science ,business.industry ,Embedded system ,Architecture ,business ,Reconfigurable computing - Published
- 2019
49. Generalized solutions describing singularity interaction
- Author
-
V. G. Danilov
- Subjects
Mathematics ,QA1-939 - Abstract
We present a new method for constructing solutions to nonlinear evolutionary equations describing the propagation and interaction of nonlinear waves.
- Published
- 2002
- Full Text
- View/download PDF
50. Protostega gigas and other sea turtles from the Campanian of Eastern Europe, Russia
- Author
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Igor G. Danilov, Ekaterina M. Obraztsova, Maxim S. Arkhangelsky, Alexey V. Ivanov, and Alexander O. Averianov
- Subjects
Paleontology - Published
- 2022
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