72 results on '"G. Cantinho"'
Search Results
2. Doença arterial coronária, perfusão miocárdica e função ventricular em enfartes do miocárdio com onda Q e sem onda Q.
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E Macieira-Coelho, M Garcia-Alves, B da Costa, G Cantinho, P Pedro, I Dionisio, A Gouveia, and F de Padua
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Medicine ,Medicine (General) ,R5-920 - Abstract
Controversy remains in considering non-Q wave myocardial infarction (NQMI) a distinct pathophysiological entity of Q wave myocardial infarction (QMI). In order to analyze the severity of coronary artery disease, extension of myocardial scar or myocardial ischemia and ventricular function, 78 consecutive patients with QMI and 32 with NQMI, mean age 55.4 +/- 8.5, not submitted to thrombolytic therapy, were studied. Coronary angiography, exercise thallium scintigraphy and radionuclide ventriculography were performed in all at least within 3 months of a prior myocardial infarction. In the present study the occurrence of QMI was significantly more frequent in older patients than NQMI. There was no prevalence of occlusion either in the right, left circumflex or left anterior descending coronary arteries in both groups. Ejection fraction, degree of occlusion and presence of collateral circulation showed an equal prevalence in QMI and NQMI patients. A higher incidence of multivessel disease was found in NQMI that had less necrosis than QMI patients. The prevalence of exercise induced thallium-201 redistribution defects within the infarct zone was substantially higher and involved more scar segments in NQMI patients. Physiological and clinical consequences of coronary thrombosis depends on the size and the number of diseased arteries, the approach the pathophysiologic consequences of coronary disease in terms of fractal structure has been suggested. A pronounced heterogeneity in regional myocardial blood flow in a fractal branching arterial network may be responsible for the pathophysiologic differences of coronary thrombosis between Q-wave and non Q-wave infarction.
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- 1997
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3. Evaluation of the Portuguese population exposure to ionizing radiation due to x-ray and nuclear medicine procedures from 2013 to 2017
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V. Antunes, L. Líbano, Senhorinha F. C. F. Teixeira, J. Silveira, Pedro Teles, J. Robalo, A. Geão, D. Calado, F. Godinho, P. Simaozinho, Francisco Alves, Alexandra Vaz, D. Neves, M. Trincão, A.L. Carvalho, R. Moreira, Eduarda Pereira, S. Pintao, J. Isidoro, H. Pereira, M.F. Loureiro, Jorge Pereira, J. Vale, J.A.M. Santos, João Santos, G. Cantinho, Prudência Vaz, A. Domingues, R. Macedo, Maura Santos Reis de Andrade da Silva, I. Lança, and A. Pimenta Marinho
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endocrine system ,Radiation ,010308 nuclear & particles physics ,business.industry ,Radiation dose ,X-ray ,Bone imaging ,Collective dose ,01 natural sciences ,Effective dose (radiation) ,030218 nuclear medicine & medical imaging ,Ionizing radiation ,03 medical and health sciences ,0302 clinical medicine ,0103 physical sciences ,Cardiac procedures ,Medicine ,Portuguese population ,Nuclear medicine ,business - Abstract
This work provides an estimation of the exposure of the Portuguese population to ionizing radiation due to radiodiagnostic (x-ray and nuclear medicine (NM)) procedures, between 2013 and 2017, using the methodology proposed by the European Commission. Obtained results show that the estimated annual mean effective dose to the Portuguese population due to x-ray procedures increased by about 16%, from 0.75 ± 0.48 mSv per caput in 2013 to 0.89 ± 0.56 mSv per caput in 2017. The x-ray exam type that contributes the most to the collective dose in Portugal is Computed Tomography (CT). In the case of nuclear medicine, an increase in the annual effective dose from 0.088 ± 0.001 mSv per caput in 2013 to 0.090 ± 0.002 mSv per caput in 2017 was observed, with the procedures that contribute the most to the collective dose being bone imaging and cardiac procedures. This study intends to raise awareness to the need of optimization of radiation dose in medical procedures.
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- 2020
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4. Significado do supradesnivelamento ST de esforço em doentes com enfarte do miocárdio.
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M Carvalho, G Cantinho, A P de Lacerda, I Dionísio, B B da Costa, M G Alves, F De Pádua, and E Macieira-Coelho
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Medicine ,Medicine (General) ,R5-920 - Abstract
In 52 patients with previous myocardial infraction, 49 men and 3 women (mean age 56 +/- 7.1 years) the significance of ST-segment elevation during the stress-test, was evaluated. Of the 52 patients 15 (29%) showed St-segment elevation and 37(71%), showed no alteration of the ST-segment. Extension of coronary disease, degree of obstruction, wall motion abnormalities and the presence of residual ischemia were evaluated by coronary angiography, technetium-99M pyrophosphate imaging and exercise TL-201 scintigraphy. From the results of the study one may conclude that, in patients with previous myocardial infraction exercise, ST-segment elevation is a consequence of sub-occlusion of the left anterior descending coronary artery with severe ventricular dysfunction either in patients with one or multiple vessel disease.
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- 1993
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5. Angiografia de radionuclídos de equílibrio em doentes com enfarte do miocárdio prévio. Correlação com o electrocardiograma e a coronariografia.
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E Macieira-Coelho, M Carvalho, I Dionísio, A Prudêncio, J A da Cunha, and G Cantinho
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Medicine ,Medicine (General) ,R5-920 - Abstract
Fifty five patients with previous myocardial infarction (MI), 47 male and 8 female, mean age 55.5 +/- 8.9 years, have been studied in order to correlate the alterations found on the equilibrium (gated) radionuclide angiogram (RNA) with the location of the MI on the electrocardiogram of the obstructive lesions on coronary angiographies. Of the 55 patients studied, 22% showed no regional wall motion abnormalities (WMA). Both MI with and without Q wave may show WMA, which are significatively more frequent in patients with anterior MI on the ECG and with occlusive lesions (greater than 90%) on coronariographies. Regional localization of the WMA on the RNA does not identify the localization of the obstructive lesions. Hypokinesia was the most frequent type of WMA found both with occlusive (greater than 90%) and sub-occlusive (greater than 75%) lesions. Low values of the ejection fraction (less than 45%) were found in the presence of WMA and occlusive artery lesions.
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- 1990
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6. Moderated Poster Session 3: Monday 4 May 2015, 10:00-11:00 * Room: Moderated Poster Area
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T. Pellegrino, M. Petretta, A. Boemio, V. Piscopo, R. Carotenuto, B. Russo, S. Pellegrino, G. De Matteis, A. Cuocolo, D. V. Ryzhkova, I. Kostina, M. Azevedo Coutinho, N. Cortez-Dias, G. Cantinho, T. Guimaraes, G. Silva, M. Menezes, A. Francisco, R. Placido, I. Conceicao, F. Pinto, K. Nakajima, T. Nakata, S. Matsuo, A. Jacobson, C. A. Paterson, A. J. Al Jabri, J. Robinson, W. Martin, S. Reid, S. A. Smith, H. Harms, L. Tolbod, T. Kero, K. Bouchelouche, J. Frokiaer, J. Sorensen, S. Kinuya, and M. Yamagishi
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Gerontology ,Medical education ,business.industry ,Medicine ,Radiology, Nuclear Medicine and imaging ,General Medicine ,Session (computer science) ,Cardiology and Cardiovascular Medicine ,business - Published
- 2015
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7. Abstracts
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V. Dunet, A. Dabiri, G. Allenbach, A. Goyeneche Achigar, B. Waeber, F. Feihl, R. Heinzer, J. O. Prior, J. E. Van Velzen, J. D. Schuijf, F. R. De Graaf, M. A. De Graaf, M. J. Schalij, L. J. Kroft, A. De Roos, J. W. Jukema, E. E. Van Der Wall, J. J. Bax, E. Lankinen, A. Saraste, T. Noponen, R. Klen, M. Teras, T. Kokki, S. Kajander, M. Pietila, H. Ukkonen, J. Knuuti, A. P. Pazhenkottil, R. N. Nkoulou, J. R. Ghadri, B. A. Herzog, R. R. Buechel, S. M. Kuest, M. Wolfrum, O. Gaemperli, L. Husmann, P. A. Kaufmann, D. Andreini, G. Pontone, S. Mushtaq, L. Antonioli, E. Bertella, A. Formenti, S. Cortinovis, G. Ballerini, C. Fiorentini, M. Pepi, A. S. Koh, J. S. Flores, F. Y. J. Keng, R. S. Tan, T. S. J. Chua, A. D. Annoni, G. Tamborini, M. Fusari, A. L. Bartorelli, S. H. Ewe, A. C. T. Ng, V. Delgado, J. Schuijf, F. Van Der Kley, A. Colli, A. De Weger, N. A. Marsan, K. H. Yiu, A. C. Ng, S. A. J. Timmer, P. Knaapen, T. Germans, P. A. Dijkmans, M. Lubberink, J. M. Ten Berg, F. J. Ten Cate, I. K. Russel, A. A. Lammertsma, A. C. Van Rossum, Y. Y. Wong, G. Ruiter, P. Raijmakers, W. J. Van Der Laarse, N. Westerhof, A. Vonk-Noordegraaf, G. Youssef, E. Leung, G. Wisenberg, C. Marriot, K. Williams, J. Etele, R. A. Dekemp, J. Dasilva, D. Birnie, R. S. B. Beanlands, R. C. Thompson, A. H. Allam, L. S. Wann, A. H. Nureldin, G. Adelmaksoub, I. Badr, M. L. Sutherland, J. D. Sutherland, M. I. Miyamoto, G. S. Thomas, H. J. Harms, S. De Haan, M. C. Huisman, R. C. Schuit, A. D. Windhorst, C. Allaart, A. J. Einstein, T. Khawaja, C. Greer, A. Chokshi, M. Jones, K. Schaefle, K. Bhatia, D. Shimbo, P. C. Schulze, A. Srivastava, R. Chettiar, J. Moody, C. Weyman, D. Natale, W. Bruni, Y. Liu, E. Ficaro, A. J. Sinusas, A. Peix, E. Batista, L. O. Cabrera, K. Padron, L. Rodriguez, B. Sainz, V. Mendoza, R. Carrillo, Y. Fernandez, E. Mena, A. Naum, T. Bach-Gansmo, N. Kleven-Madsen, M. Biermann, B. Johnsen, J. Aase Husby, S. Rotevatn, J. E. Nordrehaug, J. Schaap, R. M. Kauling, M. C. Post, B. J. W. M. Rensing, J. F. Verzijlbergen, J. Sanchez, G. Giamouzis, N. Tziolas, P. Georgoulias, G. Karayannis, A. Chamaidi, N. Zavos, K. Koutrakis, G. Sitafidis, J. Skoularigis, F. Triposkiadis, S. Radovanovic, A. Djokovic, D. V. Simic, M. Krotin, A. Savic-Radojevic, M. Pljesa-Ercegovac, M. Zdravkovic, J. Saponjski, S. Jelic, T. Simic, R. Eckardt, B. J. Kjeldsen, L. I. Andersen, T. Haghfelt, P. Grupe, A. Johansen, B. Hesse, H. Pena, G. Cantinho, M. Wilk, Y. Srour, F. Godinho, N. Zafrir, A. Gutstein, I. Mats, A. Battler, A. Solodky, E. Sari, N. Singh, A. Vara, A. M. Peters, A. De Belder, S. Nair, N. Ryan, R. James, S. Dizdarevic, G. Depuey, M. Friedman, R. Wray, R. Old, H. Babla, B. Chuanyong, J. Maddahi, E. Tragardh Johansson, K. Sjostrand, L. Edenbrandt, S. Aguade-Bruix, G. Cuberas-Borros, M. N. Pizzi, M. Sabate-Fernandez, G. De Leon, D. Garcia-Dorado, J. Castell-Conesa, J. Candell-Riera, D. Casset-Senon, M. Edjlali-Goujon, D. Alison, A. Delhommais, P. Cosnay, C. S. Low, A. Notghi, J. O'brien, A. C. Tweddel, N. Bingham, P. O Neil, M. Harbinson, O. Lindner, W. Burchert, M. Schaefers, C. Marcassa, R. Campini, P. Calza, O. Zoccarato, A. Kisko, J. Kmec, M. Babcak, M. Vereb, M. Vytykacova, J. Cencarik, P. Gazdic, J. Stasko, A. Abreu, E. Pereira, L. Oliveira, P. Colarinha, V. Veloso, I. Enriksson, G. Proenca, P. Delgado, L. Rosario, J. Sequeira, I. Kosa, I. Vassanyi, C. S. Egyed, G. Y. Kozmann, S. Morita, M. Nanasato, I. Nanbu, Y. Yoshida, H. Hirayama, A. Allam, A. Sharef, I. Shawky, M. Farid, M. Mouden, J. P. Ottervanger, J. R. Timmer, M. J. De Boer, S. Reiffers, P. L. Jager, S. Knollema, G. M. Nasr, M. Mohy Eldin, M. Ragheb, I. Casans-Tormo, R. Diaz-Exposito, F. J. Hurtado-Mauricio, R. Ruano, M. Diego, F. Gomez-Caminero, C. Albarran, A. Martin De Arriba, A. Rosero, R. Lopez, C. Martin Luengo, J. R. Garcia-Talavera, I. E. K. Laitinen, M. Rudelius, E. Weidl, G. Henriksen, H. J. Wester, M. Schwaiger, X. B. Pan, T. Schindler, A. Quercioli, H. Zaidi, O. Ratib, J. M. Declerck, E. Alexanderson Rosas, R. Jacome, M. Jimenez-Santos, E. Romero, M. A. Pena-Cabral, A. Meave, J. Gonzalez, F. Rouzet, L. Bachelet, J. M. Alsac, M. Suzuki, L. Louedec, A. Petiet, F. Chaubet, D. Letourneur, J. B. Michel, D. Le Guludec, A. Aktas, A. Cinar, G. Yaman, T. Bahceci, K. Kavak, A. Gencoglu, A. Jimenez-Heffernan, E. Sanchez De Mora, J. Lopez-Martin, R. Lopez-Aguilar, C. Ramos, C. Salgado, A. Ortega, C. Sanchez-Gonzalez, J. Roa, A. Tobaruela, S. V. Nesterov, O. Turta, M. Maki, C. Han, D. Daou, M. Tawileh, S. O. Chamouine, C. Coaguila, E. Mariscal-Labrador, N. Kisiel-Gonzalez, P. De Araujo Goncalves, P. J. Sousa, H. Marques, J. O'neill, J. Pisco, R. Cale, J. Brito, A. Gaspar, F. P. Machado, J. Roquette, M. Martinez, G. Melendez, E. Kimura, J. M. Ochoa, A. M. Alessio, A. Patel, R. Lautamaki, F. M. Bengel, J. B. Bassingthwaighte, J. H. Caldwell, K. Rahbar, H. Seifarth, M. Schafers, L. Stegger, T. Spieker, A. Hoffmeier, D. Maintz, H. Scheld, O. Schober, M. Weckesser, H. Aoki, I. Matsunari, K. Kajinami, M. Martin Fernandez, M. Barreiro Perez, O. V. Fernandez Cimadevilla, D. Leon Duran, E. Velasco Alonso, J. P. Florez Munoz, L. H. Luyando, C. Templin, C. E. Veltman, J. H. C. Reiber, S. Venuraju, A. Yerramasu, S. Atwal, A. Lahiri, T. Kunimasa, M. Shiba, K. Ishii, J. Aikawa, E. S. J. Kroner, K. T. Ho, Q. W. Yong, K. C. Chua, C. Panknin, C. J. Roos, J. M. Van Werkhoven, A. J. Witkowska-Grzeslo, M. J. Boogers, D. V. Anand, D. Dey, D. Berman, F. Mut, R. Giubbini, L. Lusa, T. Massardo, A. Iskandrian, M. Dondi, A. Sato, Y. Kakefuda, E. Ojima, T. Adachi, A. Atsumi, T. Ishizu, Y. Seo, M. Hiroe, K. Aonuma, M. Kruk, R. Pracon, C. Kepka, J. Pregowski, A. Kowalewska, M. Pilka, M. Opolski, I. Michalowska, Z. Dzielinska, M. Demkow, V. Stoll, N. Sabharwal, A. Chakera, O. Ormerod, H. Fernandes, M. Bernardes, E. Martins, P. Oliveira, T. Vieira, G. Terroso, A. Oliveira, T. Faria, F. Ventura, J. Pereira, S. Fukuzawa, M. Inagaki, J. Sugioka, A. Ikeda, S. Okino, J. Maekawa, T. Uchiyama, N. Kamioka, S. Ichikawa, M. Afshar, R. Alvi, N. Aguilar, R. Ippili, H. Shaqra, J. Bella, N. Bhalodkar, A. Dos Santos, M. Daicz, L. O. Cendoya, H. G. Marrero, J. Casuscelli, M. Embon, G. Vera Janavel, E. Duronto, E. P. Gurfinkel, C. M. Cortes, Y. Takeishi, K. Nakajima, Y. Yamasaki, T. Nishimura, K. Hayes Brown, F. Collado, M. Alhaji, J. Green, S. Alexander, R. Vashistha, S. Jain, F. Aldaas, J. Shanes, R. Doukky, K. Ashikaga, Y. J. Akashi, M. Uemarsu, R. Kamijima, K. Yoneyama, K. Omiya, Y. Miyake, Y. Brodov, U. Raval, A. Berezin, V. Seden, E. Koretskaya, T. A. Panasenko, S. Matsuo, S. Kinuya, J. Chen, R. J. Van Bommel, B. Van Der Hiel, P. Dibbets-Schneider, E. V. Garcia, I. Rutten-Vermeltfoort, M. M. J. Gevers, B. Verhoeven, A. B. Dijk Van, E. Raaijmakers, P. G. H. M. Raijmakers, J. E. Engvall, M. Gjerde, J. De Geer, E. Olsson, P. Quick, A. Persson, M. Mazzanti, M. Marini, L. Pimpini, G. P. Perna, C. Marciano, P. Gargiulo, M. Galderisi, C. D'amore, G. Savarese, L. Casaretti, S. Paolillo, A. Cuocolo, P. Perrone Filardi, M. Al-Amoodi, E. C. Thompson, K. Kennedy, K. A. Bybee, A. I. Mcghie, J. H. O'keefe, T. M. Bateman, R. L. F. Van Der Palen, A. M. Mavinkurve-Groothuis, B. Bulten, L. Bellersen, H. W. M. Van Laarhoven, L. Kapusta, L. F. De Geus-Oei, P. P. Pollice, M. B. Bonifazi, F. P. Pollice, I. P. Clements, D. O. Hodge, C. G. Scott, M. De Ville De Goyet, B. Brichard, T. Pirotte, S. Moniotte, R. A. Tio, A. Elvan, R. A. I. O. Dierckx, R. H. J. A. Slart, T. Furuhashi, M. Moroi, H. Hase, N. Joki, H. Masai, R. Nakazato, H. Fukuda, K. Sugi, K. Kryczka, E. Kaczmarska, J. Petryka, L. Mazurkiewicz, W. Ruzyllo, P. Smanio, E. Vieira Segundo, M. Siqueira, J. Kelendjian, J. Ribeiro, J. Alaca, M. Oliveira, F. Alves, I. Peovska, J. Maksimovic, M. Vavlukis, N. Kostova, D. Pop Gorceva, V. Majstorov, M. Zdraveska, S. Hussain, M. Djearaman, E. Hoey, L. Morus, O. Erinfolami, A. Macnamara, M. P. Opolski, A. Witkowski, V. Berti, F. Ricci, R. Gallicchio, W. Acampa, G. Cerisano, C. Vigorito, R. Sciagra', A. Pupi, H. Sliem, F. M. Collado, S. Schmidt, A. Maheshwari, R. Kiriakos, V. Mwansa, S. Ljubojevic, S. Sedej, M. Holzer, G. Marsche, V. Marijanski, J. Kockskaemper, B. Pieske, A. Ricalde, G. Alexanderson, A. Mohani, P. Khanna, A. Sinusas, F. Lee, V. A. Pinas, B. L. F. Van Eck-Smit, H. J. Verberne, C. M. De Bruin, G. Guilhermina, L. Jimenez-Angeles, O. Ruiz De Jesus, O. Yanez-Suarez, E. Vallejo, E. Reyes, M. Chan, M. L. Hossen, S. R. Underwood, A. Karu, S. Bokhari, V. Pineda, L. M. Gracia-Sanchez, A. Garcia-Burillo, K. Zavadovskiy, Y. U. Lishmanov, W. Saushkin, I. Kovalev, A. Chernishov, A. Annoni, M. Tarkia, T. Saanijoki, V. Oikonen, T. Savunen, M. A. Green, M. Strandberg, A. Roivainen, M. C. Gaeta, C. Artigas, J. Deportos, L. Geraldo, A. Flotats, V. La Delfa, I. Carrio, W. J. Laarse, M. M. Izquierdo Gomez, J. Lacalzada Almeida, A. Barragan Acea, A. De La Rosa Hernandez, R. Juarez Prera, G. Blanco Palacios, J. A. Bonilla Arjona, J. J. Jimenez Rivera, J. L. Iribarren Sarrias, I. Laynez Cerdena, A. Dedic, A. Rossi, G. J. R. Ten Kate, A. Dharampal, A. Moelker, T. W. Galema, N. Mollet, P. J. De Feyter, K. Nieman, D. Trabattoni, A. Broersen, M. Frenay, M. M. Boogers, P. H. Kitslaar, J. Dijkstra, D. A. Annoni, M. Muratori, N. Johki, M. Tokue, A. S. Dharampal, A. C. Weustink, L. A. E. Neefjes, S. L. Papadopoulou, C. Chen, N. R. A. Mollet, E. H. Boersma, G. P. Krestin, J. A. Purvis, D. Sharma, S. M. Hughes, D. S. Berman, R. Taillefer, J. Udelson, M. Devine, J. Lazewatsky, G. Bhat, D. Washburn, D. Patel, T. Mazurek, S. Tandon, S. Bansal, S. Inzucchi, L. Staib, J. Davey, D. Chyun, L. Young, F. Wackers, M. T. Harbinson, G. Wells, J. Dougan, S. Borges-Neto, H. Phillips, A. Farzaneh-Far, Z. Starr, L. K. Shaw, M. Fiuzat, C. O'connor, M. Henzlova, W. L. Duvall, A. Levine, U. Baber, L. Croft, S. Sahni, S. Sethi, L. Hermann, A. Nureldin, A. Gomaa, M. A. T. Soliman, H. A. R. Hany, F. De Graaf, A. Pazhenkottil, H. M. J. Siebelink, J. H. Reiber, M. Ayub, T. Naveed, M. Azhar, A. Van Tosh, T. L. Faber, J. R. Votaw, N. Reichek, B. Pulipati, C. Palestro, K. J. Nichols, K. Okuda, Y. Kirihara, T. Ishikawa, J. Taki, M. Yoshita, M. Yamada, A. Salacata, S. Keavey, V. Chavarri, J. Mills, H. Nagaraj, P. Bhambhani, D. E. Kliner, P. Soman, J. Heo, A. E. Iskandrian, M. Jain, B. Lin, A. Walker, C. Nkonde, S. Bond, A. Baskin, J. Declerck, M. E. Soto, G. Mendoza, M. Aguilar, S. P. Williams, G. Colice, J. R. Mcardle, A. Lankford, D. K. Kajdasz, C. R. Reed, L. Angelini, F. Angelozzi, G. Ascoli, A. Jacobson, H. J. Lessig, M. C. Gerson, M. D. Cerqueira, J. Narula, M. Uematsu, K. Kida, K. Suzuki, P. E. Bravo, K. Fukushima, M. Chaudhry, J. Merrill, A. Alonso Tello, J. F. Rodriguez Palomares, G. Marti Aguasca, S. Aguade Bruix, V. Aliaga, P. Mahia, T. Gonzalez-Alujas, J. Candell, A. Evangelista, R. Mlynarski, A. Mlynarska, M. Sosnowski, B. Zerahn, P. Hasbak, C. E. Mortensen, H. F. Mathiesen, M. Andersson, D. Nielsen, L. Ferreira Santos, M. J. Ferreira, D. Ramos, D. Moreira, M. J. Cunha, A. Albuquerque, A. Moreira, J. Oliveira Santos, G. Costa, L. A. Providencia, Y. Arita, S. Kihara, N. Mitsusada, M. Miyawaki, H. Ueda, H. Hiraoka, Y. Matsuzawa, J. Askew, M. O'connor, L. Jordan, R. Ruter, R. Gibbons, T. Miller, L. Emmett, A. Ng, N. Sorensen, R. Mansberg, L. Kritharides, T. Gonzalez, H. Majmundar, N. P. Coats, S. Vernotico, J. H. Doan, T. M. Hernandez, M. Evini, A. D. Hepner, T. K. Ip, W. A. Chalela, A. M. Falcao, L. O. Azouri, J. A. F. Ramires, J. C. Meneghetti, F. Manganelli, M. Spadafora, P. Varrella, G. Peluso, R. Sauro, E. Di Lorenzo, F. Rotondi, S. Daniele, P. Miletto, A. J. M. Rijnders, B. W. Hendrickx, W. Van Der Bruggen, Y. G. C. J. America, P. J. Thorley, F. U. Chowdhury, C. J. Dickinson, S. I. Sazonova, I. Y. U. Proskokova, A. M. Gusakova, S. M. Minin, Y. U. B. Lishmanov, V. V. Saushkin, G. Rodriguez, F. Roffe, H. Ilarraza, D. Bialostozky, A. N. Kitsiou, P. Arsenos, I. Tsiantis, S. Charizopoulos, S. Karas, R. C. Vidal Perez, M. Garrido, V. Pubul, S. Argibay, C. Pena, M. Pombo, A. B. Ciobotaru, A. Sanchez-Salmon, A. Ruibal Morell, J. R. Gonzalez-Juanatey, E. Rodriguez-Gomez, B. Martinez, D. Pontillo, F. Benvissuto, F. Fiore Melacrinis, S. Maccafeo, E. V. Scabbia, R. Schiavo, Y. Golzar, C. Gidea, J. Golzar, D. Pop-Gorceva, M. Zdravkovska, S. Stojanovski, L. J. Georgievska-Ismail, T. Katsikis, A. Theodorakos, A. Kouzoumi, M. Koutelou, Y. Yoshimura, T. Toyama, H. Hoshizaki, S. Ohshima, M. Inoue, T. Suzuki, A. Uitterdijk, M. Dijkshoorn, M. Van Straten, W. J. Van Der Giessen, D. J. Duncker, D. Merkus, G. Platsch, J. Sunderland, C. Tonge, P. Arumugam, T. Dey, H. Wieczorek, R. Bippus, R. L. Romijn, B. E. Backus, T. Aach, M. Lomsky, L. Johansson, J. Marving, S. Svensson, J. L. Pou, F. P. Esteves, P. Raggi, R. Folks, Z. Keidar, J. W. Askew, L. Verdes, L. Campos, V. Gulyaev, A. Pankova, J. Santos, S. Carmona, I. Henriksson, A. Prata, M. Carrageta, A. I. Santos, K. Yoshinaga, M. Naya, C. Katoh, O. Manabe, S. Yamada, H. Iwano, S. Chiba, H. Tsutsui, N. Tamaki, I. Vassiliadis, E. Despotopoulos, O. Kaitozis, E. Hatzistamatiou, R. Thompson, J. Hatch, M. Zink, B. S. Gu, G. D. Bae, C. M. Dae, G. H. Min, E. J. Chun, S. I. Choi, M. Al-Mallah, K. Kassem, O. Khawaja, D. Goodman, D. Lipkin, L. Christiaens, B. Bonnet, J. Mergy, D. Coisne, J. Allal, N. Dias Ferreira, D. Leite, J. Rocha, M. Carvalho, D. Caeiro, N. Bettencourt, P. Braga, V. Gama Ribeiro, U. S. Kristoffersen, A. M. Lebech, H. Gutte, R. S. Ripa, N. Wiinberg, C. L. Petersen, G. Jensen, A. Kjaer, C. Bai, R. Conwell, R. D. Folks, L. Verdes-Moreiras, D. Manatunga, A. F. Jacobson, D. Belzer, Y. Hasid, M. Rehling, R. H. Poulsen, L. Falborg, J. T. Rasmussen, L. N. Waehrens, C. W. Heegaard, J. M. U. Silvola, S. Forsback, J. O. Laine, S. Heinonen, S. Ylaherttuala, A. Broisat, M. Ruiz, N. C. Goodman, J. Dimastromatteo, D. K. Glover, F. Hyafil, F. Blackwell, G. Pavon-Djavid, L. Sarda-Mantel, L. J. Feldman, A. Meddahi-Pelle, V. Tsatkin, Y.- H. Liu, R. De Kemp, P. J. Slomka, R. Klein, G. Germano, R. S. Beanlands, A. Rohani, V. Akbari, J. G. J. Groothuis, M. Fransen, A. M. Beek, S. L. Brinckman, M. R. Meijerink, M. B. M. Hofman, C. Van Kuijk, S. Kogure, E. Yamashita, J. Murakami, R. Kawaguchi, H. Adachi, S. Oshima, S. Minin, S. Popov, Y. U. Saushkina, G. Savenkova, D. Lebedev, E. Alexandridis, D. Rovithis, C. Parisis, I. Sazonova, V. Saushkin, V. Chernov, L. Zaabar, H. Bahri, S. Hadj Ali, A. Sellem, I. Slim, N. El Kadri, H. Slimen, H. Hammami, S. Lucic, A. Peter, S. Tadic, K. Nikoletic, R. Jung, M. Lucic, K. Tagil, D. Jakobsson, S.- E. Svensson, P. Wollmer, L. Leccisotti, L. Indovina, L. Paraggio, M. L. Calcagni, A. Giordano, M. Kapitan, A. Paolino, M. Nunez, J. Sweeny, N. Kulkarni, K. Guma, Y. Akashi, M. Takano, M. Takai, S. Koh, F. Miyake, N. Torun, G. Durmus Altun, A. Altun, E. Kaya, H. Saglam, D. T. Matsuoka, A. Sanchez, C. Bartolozzi, D. Padua, G. Ponta, A. Ponte, A. Carneiro, A. Thom, R. Ashrafi, P. Garg, G. Davis, A. Falcao, M. Costa, F. Bussolini, J. A. C. Meneghetti, M. Tobisaka, E. Correia, J. W. Jansen, P. A. Van Der Vleuten, T. P. Willems, F. Zijlstra, M. Sato, K. Taniguchi, M. Kurabayashi, D. Pop Gjorcheva, M. Zdraveska-Kochovska, K. Moriwaki, A. Kawamura, K. Watanabe, T. Omura, S. Sakabe, T. Seko, A. Kasai, M. Ito, M. Obana, T. Akasaka, C. Hruska, D. Truong, C. Pletta, D. Collins, C. Tortorelli, D. Rhodes, M. El-Prince, A. Martinez-Moeller, M. Marinelli, S. Weismueller, C. Hillerer, B. Jensen, S. G. Nekolla, H. Wakabayashi, K. Tsukamoto, S. M. E. A. Baker, K. M. H. S. Sirajul Haque, A. Siddique, S. Krishna Banarjee, A. Ahsan, F. Rahman, M. Mukhlesur Rahman, T. Parveen, M. Lutfinnessa, F. Nasreen, H. Sano, S. Naito, M. L. De Rimini, G. Borrelli, F. Baldascino, P. Calabro, C. Maiello, A. Russo, C. Amarelli, P. Muto, I. Danad, P. G. Raijmakers, Y. E. Appelman, O. S. Hoekstra, J. T. Marcus, A. Boonstra, D. V. Ryzhkova, T. V. Kuzmina, O. S. Borodina, M. A. Trukshina, I. S. Kostina, H. Hommel, G. Feuchtner, O. Pachinger, G. Friedrich, A. M. Stel, J. W. Deckers, V. Gama, A. Ciarka, L. A. Neefjes, N. R. Mollet, E. J. Sijbrands, J. Wilczek, C. Llibre Pallares, O. Abdul-Jawad Altisent, H. Cuellar Calabria, P. Mahia Casado, M. T. Gonzalez-Alujas, A. Evangelista Masip, D. Garcia-Dorado Garcia, Y. Tekabe, X. Shen, Q. Li, J. Luma, D. Weisenberger, A. M. Schmidt, R. Haubner, L. Johnson, L. Sleiman, S. Thorn, M. Hasu, M. Thabet, J. N. Dasilva, S. C. Whitman, D. Genovesi, A. Giorgetti, A. Gimelli, G. Cannizzaro, F. Bertagna, G. Fagioli, M. Rossi, R. Bonini, P. Marzullo, C. A. Paterson, S. A. Smith, A. D. Small, N. E. R. Goodfield, W. Martin, S. Nekolla, H. Sherif, S. Reder, M. Yu, A. Kusch, D. Li, J. Zou, M. S. Lloyd, K. Cao, D. W. Motherwell, A. Rice, G. M. Mccurrach, S. M. Cobbe, M. C. Petrie, I. Al Younis, E. Van Der Wall, T. Mirza, M. Raza, H. Hashemizadeh, L. Santos, B. A. Krishna, F. Perna, M. Lago, M. Leo, G. Pelargonio, G. Bencardino, M. L. Narducci, M. Casella, F. Bellocci, S. Kirac, O. Yaylali, M. Serteser, T. Yaylali, A. Okizaki, Y. Urano, M. Nakayama, S. Ishitoya, J. Sato, Y. Ishikawa, M. Sakaguchi, N. Nakagami, T. Aburano, S. V. Solav, R. Bhandari, S. Burrell, S. Dorbala, I. Bruno, C. Caldarella, A. Collarino, M. V. Mattoli, A. Stefanelli, A. Cannarile, F. Maggi, V. Soukhov, S. Bondarev, A. Yalfimov, M. Khan, P. P. Priyadharshan, G. Chandok, T. Aziz, M. Avison, R. A. Smith, D. S. Bulugahapitya, T. Vakhtangadze, F. Todua, M. Baramia, G. Antelava, N.- C. Roche, P. Paule, S. Kerebel, J.- M. Gil, L. Fourcade, A. Tzonevska, K. Tzvetkov, M. Atanasova, V. Parvanova, A. Chakarova, E. Piperkova, B. Kocabas, H. Muderrisoglu, C. P. Allaart, E. Entok, S. Simsek, B. Akcay, I. Ak, E. Vardareli, M. Stachura, P. J. Kwasiborski, G. J. Horszczaruk, E. Komar, A. Cwetsch, B. Zraik, R. Morales Demori, A. D. J. Almeida, M. E. Siqueira, E. Vieira, I. Balogh, G. Kerecsen, E. Marosi, Z. S. Szelid, A. Sattar, T. Swadia, J. Chattahi, W. Qureshi, F. Khalid, A. Gonzalez, S. Hechavarria, K. Takamura, S. Fujimoto, R. Nakanishi, S. Yamashina, A. Namiki, J. Yamazaki, K. Koshino, Y. Hashikawa, N. Teramoto, M. Hikake, S. Ishikane, T. Ikeda, H. Iida, Y. Takahashi, N. Oriuchi, H. Higashino, K. Endo, T. Mochizuki, K. Murase, A. Baali, R. Moreno, M. Chau, H. Rousseau, F. Nicoud, P. Dolliner, L. Brammen, G. Steurer, T. Traub-Weidinger, P. Ubl, P. Schaffarich, G. Dobrozemsky, A. Staudenherz, M. Ozgen Kiratli, B. Temelli, N. B. Kanat, T. Aksoy, G. A. Slavich, G. Piccoli, M. Puppato, S. Grillone, D. Gasparini, S. Perruchoud, C. Poitry-Yamate, M. Lepore, R. Gruetter, T. Pedrazzini, D. Anselm, A. Anselm, H. Atkins, J. Renaud, R. Dekemp, I. Burwash, A. Guo, R. Beanlands, C. Glover, I. Vilardi, B. Zangheri, L. Calabrese, P. Romano, A. Bruno, O. C. Fernandez Cimadevilla, V. A. Uusitalo, M. Luotolahti, M. Wendelin-Saarenhovi, J. Sundell, O. Raitakari, S. Huidu, R. Gadiraju, M. Ghesani, Q. Uddin, B. Wosnitzer, N. Takahashi, E. Alhaj, A. Legasto, B. Abiri, K. Elsaban, T. El Khouly, T. El Kammash, A. Al Ghamdi, B. Kyung Deok, K. Bon Seung, Y. Sang Geun, D. Chang Min, and M. Gwan Hong
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Cardiology and Cardiovascular Medicine - Published
- 2011
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8. Role of Myocardial Ischemia and Left Ventricular Wall Motion Abnormalities as Contributory Factors in the Genesis of Exercise-Induced ST-Segment Elevation in Q-Wave Myocardial Infarction
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A Gouveia, G Cantinho, I. Dionísio, B.C.B da Costa, Mario Garcia-Alves, and Eduardo Macieira-Coelho
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Male ,medicine.medical_specialty ,Physical Exertion ,Myocardial Infarction ,Myocardial Ischemia ,Ischemia ,Coronary Disease ,Radionuclide ventriculography ,Coronary Angiography ,QT interval ,Electrocardiography ,Ventricular Dysfunction, Left ,Coronary Circulation ,Internal medicine ,medicine ,Humans ,ST segment ,Pharmacology (medical) ,Prospective Studies ,cardiovascular diseases ,Myocardial infarction ,Radionuclide Ventriculography ,Tissue Survival ,medicine.diagnostic_test ,business.industry ,ST elevation ,Technetium ,Electrocardiography in myocardial infarction ,Middle Aged ,medicine.disease ,Coronary Vessels ,Myocardial Contraction ,Thallium Radioisotopes ,Exercise Test ,cardiovascular system ,Cardiology ,Female ,Radiopharmaceuticals ,Cardiology and Cardiovascular Medicine ,business ,Tomography, Emission-Computed - Abstract
In patients with a previous myocardial infarction, controversy exists regarding the significance of postexercise ST-segment elevation in the infarct-related leads. Although usually admitted to be a sign of left ventricular dysfunction or myocardial aneurysm, other studies however have related this finding to transient myocardial ischemia and to the presence of jeopardized but viable myocardium in the infarct area. The aim of the present study was to assess the significance of postexercise ST-segment elevation in Q-wave leads as a marker of transmural ischemia or left ventricular dysfunction in 36 consecutive patients, 16 with exercise-induced ST-segment elevation in infarct-related leads. Patients were evaluated by treadmill exercise testing, coronary angiography and ventriculography, thallium-201 tomographic scintigraphy and radionuclide ventriculography within 3 months of the first myocardial infarction. Sixteen patients (group I) had exercise-induced ST segment elevation and 20 (group II) postexercise inversion, no change or pseudonormalization of the T wave in infarct-related leads. The study showed no difference in infarct-related artery, vessel disease or luminal diameter stenosis in groups I and II. The overall agreement between ST shifts and myocardial perfusion in the infarct area was 30.56% with a κ coefficient of –0.33 (p = NS). The overall agreement between ST shifts and wall motion abnormalities was 69.44% with a κ coefficient of 0.39 (p < 0.01), stress-induced ST-segment elevation being associated with severe wall contractile disorders in 85% of the patients. In conclusion stress-induced ST-segment elevation in Q wave leads, although not a marker of wall motion abnormalities, is associated with akinesia or dyskinesia of the left ventricular wall.
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- 1999
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9. Comparison between dobutamine echocardiography and thallium-201 scintigraphy in detecting residual stenosis, ischemia, and necrosis in patients with prior myocardial infarction
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Fernando de Pádua, I. Dionísio, Eduardo Macieira-Coelho, AntÓNio Gouveia, Brás B. Da Costa, Mario Garcia-Alves, and G Cantinho
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Male ,medicine.medical_specialty ,Stress testing ,Myocardial Infarction ,Ischemia ,Coronary Disease ,Coronary Angiography ,Scintigraphy ,Sensitivity and Specificity ,Coronary artery disease ,Myocardial perfusion imaging ,Predictive Value of Tests ,Coronary Circulation ,Dobutamine ,Internal medicine ,medicine ,Stress Echocardiography ,Humans ,Clinical Investigation ,cardiovascular diseases ,Myocardial infarction ,Radionuclide Imaging ,medicine.diagnostic_test ,business.industry ,Heart ,General Medicine ,Middle Aged ,medicine.disease ,Myocardial Contraction ,Thallium Radioisotopes ,Echocardiography ,Cardiology ,Female ,Cardiology and Cardiovascular Medicine ,business ,medicine.drug - Abstract
Background: Following the first attempts to detect myocardial ischemia with two-dimensional echocardiography stress testing, pharmacologic stress using dobutamine infusion has become an alternative to echocardiography exercise testing for evaluation of coronary artery disease. It has been shown that stress echocardiography has a diagnostic accuracy similar to that of an exercise thallium test. Other studies, however, indicated that radionuclide myocardial perfusion imaging was more sensitive than exercise or pharmacologic stress echocardiography for detection of ischemia or jeopardized myocardium. Hypothesis: The aim of the present study was to determine the ability of dobutamine stress echocardiography in comparison with thallium-201 scintigraphy to identify multivessel disease and the presence of myocardial scar and ischemia in 60 consecutive patients who suffered a first myocardial infarction (MI). Methods: Patients were evaluated by coronary angiography and ventriculography, thallium-201 (201Tl) tomographic scintigraphy, and dobutamine echocardiography within 3 months of a first MI. Forty-seven had Q-wave MI and 13 had non-Q-wave MI. Eleven patients were excluded from final analysis—7 because of failure to achieve target heart rate in spite of the use of atropine, and 4 because of high blood pressure following the infusion of dobutamine. Results: Dobutamine echocardiography showed an overall sensitivity of 43% for detection of coronary artery lesions of 50–74% diameter stenosis and 201Tl scintigraphy showed a sensitivity of 71%. For detection of lesions of ≥75% diameter stenosis, dobutamine echocardiography showed a sensitivity of 52% and 201Tl a sensitivity of 70%. Overall agreement between wall motion and myocardial perfusion for detection of necrosis and/or ischemia in the infarct area was 40.4% with a kappa coefficient of 0.09 (p = 0.13). For detection of ischemic myocardium outside the infarct zone, overall agreement was 78.6% with a kappa coefficient of 0.49 (p
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- 1997
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10. Technetium-99m tetrofosmin rest/stress myocardial SPET with a same-day 2-hour protocol: comparison with coronary angiography A Spanish-Portuguese multicentre clinical trial
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J. Magriñá, J. Martin-Comin, A. Ventosa, A. T. Fonseca, G. Cantinho, J. Pedrosa, M.J. Pérez-Castejón, J. M. Latre, J. Ortiz-Berrocal, José Luis Carreras, A. Garcia, M. R. Vieira, J. A. Jurado, D. Ortega, L. Salgado, R. Montz, C. Puente, A. I. Ferre, M. J. Tabuenca, E. P. Sâ, and E. Esplugues
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Male ,medicine.medical_specialty ,Time Factors ,chemistry.chemical_element ,Coronary Disease ,Coronary Angiography ,Technetium ,Sensitivity and Specificity ,Coronary artery disease ,Myocardial perfusion imaging ,Organophosphorus Compounds ,medicine.artery ,Internal medicine ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Myocardial infarction ,Tomography, Emission-Computed, Single-Photon ,medicine.diagnostic_test ,business.industry ,Heart ,Organotechnetium Compounds ,General Medicine ,Middle Aged ,medicine.disease ,Clinical trial ,medicine.anatomical_structure ,chemistry ,Right coronary artery ,Exercise Test ,Cardiology ,Female ,Nuclear medicine ,business ,Perfusion ,Artery - Abstract
Technetium-99m tetrofosmin (Myoview) has unique properties for myocardial perfusion imaging very early after injection of the tracer. We used a very short same-day rest/stress protocol, to be performed within 2 h and evaluated its diagnostic accuracy. The study included 144 patients from seven Spanish and four Portuguese centres with a diagnosis of uncomplicated coronary artery disease (CAD); 78 patients (54%) had no history of prior myocardial infarction. Patients were injected with/=300 MBq 99mTc-tetrofosmin at rest and/=900 MBq approximately 1 h later at peak exercise. Single-photon emission tomographic (SPET) acquisitions were initiated within 5-30 min post injection. The results were compared with those of coronary angiography (CA). The data of 142 patients were completely evaluable (two with non-evaluable images were excluded). The quality of rest images was excellent or good in 86%, regionally problematic in 7%, poor but well interpretable in 5% and non-evaluable in 2%. The overall sensitivity for the detection of CAD was 93%, the specificity 38% and the accuracy 85%. The localization of defects by SPET in relation to the perfusion territories of stenosed vessels (/=50%) was achieved with a sensitivity of 64% for the left anterior descending artery, 49% for the left circumflex artery and 86% for the right coronary artery, and an accuracy of 71%, 72% and 73% respectively. Concordance of SPET and CA was 62% for single-vessel disease and 68% for multivessel disease. In conclusion, this Spanish-Portuguese multicentre clinical trial confirmed, in a considerable number of patients who underwent coronary angiography, the feasibility of 99mTc tetrofosmin (Myoview) rest/stress myocardial SPET using a very short protocol (2 h).
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- 1996
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11. Fourth meeting of the European Neurological Society 25–29 June 1994 Barcelona, Spain
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H. Hattig, C. Delli Pizzi, M. C. Addonizio, Michelle Davis, A. R. Giovagnoli, L. Florensa, M. Roth, J. de Kruijk, Francisco Lacruz, Ph. Dewailly, A. Toygar, C. Avendano, P.P. De Deyn, J. F. Hurtevent, F. Lomeila, T. W. Wong, Gordon T. Plant, M. Bud, H. J. Willison, DH Miller, D. W. Langdon, R. Cioni, J. Servan, A. Kaygisiz, E. Racadot, D. B. Schens, E. Picciola, L. Falip, C. Bouchard, J. Jotova, A. Jorge-Santamaria, P. Misra, A. Dufour, C. P. Panagopoulos, A. Venneri, B. Sredni, B. Angelard, M. Janelidze, M. Carreno, J. Obenberger, J. Pouget, H. W. Moser, R. Kaufmann, J. A. Molina, D. Linden, A. Martin Urda, E. Uvestad, A. Krone, J. P. Cochin, J. Mallecourt, A. Cambon-Thomsen, K. Violleau, P. Osschmann, A. M. Durocher, E. Bussaglia, D. M. Danielle, H. Efendi, C. Van Broeckhoven, K. G. Jordan, W. Rautenberg, C. Iniguez, J. M. Delgado, Graham Watson, M. Lawden, Gareth J. Barker, K. Stiasny, James T. Becker, G. Campanella, E. Peghi, A. Poli, A. Haddad, T. Yamawaki, Giacomo P. Comi, S. Sotgiu, B. Ersmark, A. Pomes, M. Ziegler, P. Ferrante, P. Ruppi, H. KuÇukoglu, R. Bouton, U. K. Rinne, P. Vieregge, M. Dary, P. Giunti, Peter J. Goadsby, S. Jung, E. Secor, A. Steinberg, N. Vila, M. A. Hernandez, M. Cursi, A. Enqelhardt, A. Engelhardt, J. Veitch, F. Di Silverio, F. Arnaud, B. Neundörfer, R. Brucher, Dominique Caparros-Lefebvre, B. Meyer, Marianne Dieterich, M. H. Snidaro, R. Gomez, R. Cerbo, M. Ragno, J. M. Vance, S. Nemni, A. Caliskan, F. Barros, I. Velcheva, D. Ceballos-Baumann, V. Barak, A. Avila, N. Antonova, F. Resche, S. Pappata, L. Varela, S. R. Silveira Santos, A. Cammarota, L. Naccache, Y. Nara, E. Tournier-Lasserves, R. Mobner, T. Chase, A. Ensenyat, J. Ulrich, G. Giegerich, M. Rother, M. Revilla, N. Nitschke, K. Honczarenko, E. Basart Tarrats, J. Blin, B. Jacob, J. Santamaria, S. Knezevic, J. L. Castillo, M. Antem, J. Colomer, O. Busse, Didier Hannequin, S. Carrier, J. B. Ruidavets, C. Rozman, J. Bogoussslavsky, J. Pascual Calvet, E. Monros, J. M. Polo, M. Zucconl, Javier Muruzabal, R. R. Allen, R. Rivolta, K. Haugaard, A. Nespolo, K. Hoang-Xuang, G. Bussone, T. Avramidis, E. Corsini, Christiana Franke, T. Vinogradova, H. Boot, K. Vestergaard, G. H. Jansen, N. Argentino, M. Raltzig, W. Linssen, Mark B. Pepys, P. Roblot, L. Lauritzen, E. Fainardi, D. Morin, T. X. Arbizu Urdiain, J. Wollenhaupt, S. Bostantjopoulou, G. Pavesi, A. D. Forman, Giovanni Fabbrini, D. Jean, J. J. Archelos, M. I. Blanchs, M. Del Gobbo, Anna Carla Turconi, Ch. Derouesné, Elio Scarpini, A. Visbeck, P. Castejon, J. P. Renou, F. Mounier-Vehier, G. Potagas, Ch. Duyckaerts, A. Filla, R. Schneider, G. Ronen, K. Nagata, J. P. Vedel, A. Henneberg, G. van Melle, C. Baratti, H. Knott, M. C. Prevett, A. Bes, B. Metin, Jos V. Reempts, L. Martorell, Mefkure Eraksoy, H. O. Handwerker, D. S. Younger, O. Oktem, D. Frongillo, C. Soriano-Soriano, L. Niehaus, F. Zipp, A. Tartaro, S Newman, R. H. Browne, P. Davous, R. Sanchez, M. Muros, M. E. Kornhuber, A. Lavarone, M. Mohr, M. R. 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Masana, A. Goossens, B. Heye, K. Lauer, Heinz Gregor Wieser, Stephen R. Williams, B. Garavaglia, A. P. Sempere, F. Grigoletto, P. Poindron, R. Lopez-Pajares, I. Leite, T. A. McNell, C. Caucheteur, J. M. Giron, A. D. Collins, P. Freger, J. Sanhez Del Rio, D. A. Harn, K. Lindner, S. S. Scherer, G. Serve, M. Juncadella, X. Estivill, R. Binkhorst, M. Anderson, B. Tekinsoy, C. Sagan, T. Anastopoulos, G. Japaridze, S. Guillou, F. Erminio, Jon Sussman, P. G. Oomes, D. S. Rust, S. Mascheroni, O. Berger, M. Peresson, K. V. Toyka, T. W. Polder, M. Huberman, B. Arpaci, H. Ramtami, I. Martinez, Ph. Violon, P. P. Gazzaniga Pozzill, R. Ruda, P. Auzou, J. Parker, S. P. Morrissey, Jiahong Zhu, F. Rotondi, P. Baron, W. Schmid, P. Doneda, M. Spadaro, M. C. Nargeot, I. Banchs, J.S.P. van den Berg, R. Ferrai, M. Robotti, M. Fredj, Pedro M. Rodríguez Cruz, B. Erne, D. G. Piepgras, M. C. Arne-Bes, J. Escudero, C. Goetz, A. R. Naylor, M. Hallett, O. Abramsky, E. Bonifacio, L. E. Larsson, R. Pellikka, P. Valalentino, D. Guidetti, B. Buchwald, C. H. Lücking, D. Gauvreau, F. Pfaff, A. Ben Younes-Chennoufi, R. Kiefer, R. Massot, K. A. Hossmann, L. Werdelin, P. J. Baxter, U. Ziflo, S. Allaria, C. D. Marsden, M. Cabaret, S. P. Mueller, E. Calabrese, R. Colao, S. I. Bekkelund, M. Yilmaz, O. Oktem-Tanor, R. Gine, M. E. Scheulen, J. Beuuer, A. Melo, Z. Gulay, M. D. Have, C. Frith, D. Liberati, J. Gozlan, P. Rondot, Ch. Brunholzl, M. Pocchiari, J. Pena, L. Moiola, C. Salvadori, A. Cabello, T. Catarci, S. Webb, C. Dettmers, N. A. Gregson, Alexandra Durr, F. Iglesias, U. Knorr, L. Ferrini-Strambi, F. Kruggel, P. Allard, A. Coquerel, P. Genet, F. Vinuels, C. Oberwittler, A. Torbicki, P. Leffers, B. Renault, B. Fauser, C. Ciano, G. Uziel, J. M. Gibson, F. Anaya, C. Derouesné, C. N. Anagnostou, M. Kaido, W. Eickhoff, G. Talerico, M. L. Berthier, A. Capdevila, M. Alons, D. Rezek, E. Wondrusch, U. Kauerz, D. Mateo, M. A. Chornet, Holon, N. Pinsard, I. Doganer, E. Paoino, H. Strenge, C. Diaz, J. R. Brasic, W. Heide, I. Santilli, W. M. Korn, D. Selcuki, M. J. Barrett, D. Krieger, T. Leon, T. Houallah, M. Tournilhac, C. Nos, D. Chavot, F. Barbieri, F. J. Jimenez-Jimenez, J. Muruzabal, K. Poeck, A. Sennlaub, L. M. Iriarte, L. G. Lazzarino, C. Sanz, P. A. Fischer, S. D. Shorvon, R. Hoermann, F. Delecluse, M. Krams, O. Corabianu, F. H. Hochberg, Christopher J. Mathias, B. Debachy, C. M. Poser, L. Delodovici, A. Jimenez-Escrig, F. Baruzzi, F. Godenberg, D. Cucinotta, P. J. Garcia Ruiz, K. Maier-Hauff, P. R. Bar, R. Mezt, R. Jochens, S. Karakaneva, C. Roberti, E. Caballero, Joseph E. Parisi, M. Zamboni, T. Lacasa, B. Baklan, J. C. Gautier, J. A. Martinez-Matos, W. Pollmann, G. Thomas, L. Verze, E. Chleide, R. Alvarez Sala, I. Noel, E. Albuisson, O. Kastrup, S. I. Rapoport, H. J. Braune, H. Lörler, M. Le Merrer, A. Biraben, S. Soler, S. J. Taagholt, U. Meyding-Lamadé, K. Bleasdale-Barr, Isabella Moroni, Y. Campos, J. Matias-Guiu, G. Edan, M. G. Bousser, John B. Clark, J. Garcia de Yebenes, N. K. Olsen, P. Hitzenberger, S. Einius, Aj Thompson, Ch. J. Vecht, T. Crepin-Leblond, Klaus L. Leenders, A. Di Muzio, L. Georgieva, René Spiegel, K. Sabey, D. Ménégalli, J. Meulstee, U. Liszka, P. Giral, C. Sunol, J. M. Espadaler, A. D. Crockar, K. Varli, G. Giraud, P. J. Hülser, A. Benazzouz, A. Reggio, M. Salvatore, K. Genc, M. Kushnir, S. Barbieri, J. Ph. Azulay, M. Gianelli, N. Bathien, A. AlMemar, F. Hentati, I. Ragueneau, F. Chiarotti, R. C. F. Smits, A. K. Asbury, F. Lacruz, B. Muller, Alan J. Thompson, Gordon Smith, K. Schmidt, C. Daems Monpeun, Juergen Weber, A. Arboix, G. R. Fink, A. M. Cobo, M. Ait Kaci Ahmed, E. Gencheva, Israel-Biet, G. Schlaug, P. De Jonghe, Philip Scheltens, K. Toyka, P. Gonzalez-Porque, A. Cila, J. M. Fernandez, P. Augustin, J. Siclia, S. Medaglini, D. E. Ziogas, A. Feve, L. Kater, G. J. E. Rinkel, D. Leppert, Rüdiger J. Seitz, S. Ried, C. Turc-Carel, G. Smeyers, F. Godinho, M. Czygan, M. Rijntjes, E. Aversa, M. Frigo, Leif Østergaard, J. L. Munoz Blanco, A. Cruz-Matinez, J. De Reuck, C. Theillet, T. Barroso, V. Oikonen, Florence Lebert, M. Kilinc, C. Cordon-Cardon, G. Stoll, E. Thiery, F. Pulcinelli, J. Solski, M. Schmiegelow, L. J. Polman, P. Fernandez-Calle, C. Wikkelso, M. Ben Hamida, M. Laska, E. Kott, W. Sulkowski, C. Lucas, N. M. Bornstein, D. Schmitz, M. W. Lammers, A. de Louw, R. J. S. Wise, P. A. van Darn, C. Antozzi, P. Villanueva, P. H. E. Hilkens, C. Constantin, W. Ricart, A. Wolf, M. Gamba, P. Maguire, Alessandro Padovani, B. M. Patten, Marie Sarazin, H. Ackermann, L. Durelli, S. Timsit, Sebastian Jander, B. W. Scheithauer, G. Demir, J. P. Neau, P. Barbanti, A. Brand, N. AraÇ, V. Fischer-Gagnepain, R. Marchioli, G. Serratrice, C. Maugard-Louboutin, G. T. Spencer, D. Lücke, G. Mainardi, K. Harmant Van Rijckevorsel, G. B. Creel, R. Manzanares, Francesco Fortunato, A. May, J. Workman, K. Johkura, E. Fernandez, Carlo Colosimo, L. Calliauw, L. Bet, Félix F. Cruz-Sánchez, M. Dhib, H. Meinardi, F. Carrara, J. Kuehnen, C. Peiro, H. Lassmann, K. Skovgaard Olsen, A. McDonald, L. Sciulli, A. Cobo, A. Monticelli, B. Conrad, J. Bagunya, J. Benitez, V. Desnizza, B. Dupont, O. Delrieu, D. Moraes, J. J. Heimans, F. Garcia Rio, M. Matsumto, A. Fernandez, R. Nermni, R. Chalmers, M. J. Marchau, F. Aguado, P. Velupillai, P. J. Martin, P. Tassan, V. Demarin, A. Engelien, T. Gerriets, Comar, J. L. Carrasco, J. P. Pruvo, A. Lopez de Munain, D. Pavitt, J. Alarcon, Chris H. Polman, B. Guldin, N. Yeni, Hartmut Brückmann, N. Wilczak, H. Szwed, R. Causaran, G. Kyriazis, M. E. Westarp, M. Gasparini, N. Pecora, J. M. Roda, E. Lang, V. Scaioli, David R. Fish, D. Caputo, O. Gratzl, R. Mercelis, A. Perretti, G. Steimetz, I. Link, C. Rigoletto, A. Catafau, G. Lucotte, M. Buti, G. Fagiolari, A. Piqueras, C. Godinot, J. C. Meurice, Erodriguez J. Dominigo, F. Lionnet, H. Grzelec, David J. Brooks, P. M. G. Munro, F. X. Weilbach, M. Maiwald, W. Split, B. Widjaja-Cramer, V. Ozturk, J. Colas, E. Brizioli, J. Calleja, L. Publio, M. Desi, R. Soffietti, P. Cortinovis-Tourniaire, E. F. Gonano, G. Cavaletti, S. Uselli, K. Westerlind, H. Betuel, C. O. Dhiver, H. Guggenheim, M. Hamon, R. Fazio, P. Lehikoinen, A. Esser, B. Sadzot, G. Fink, Angelo Antonini, D. Bendahan, V. Di Carlo, G. Galardi, A. F. Boller, M. Aksenova, Del Fiore, V. de la Sayette, H. Chabriat, A. Nicoletti, A. Dilouya, M. L. Harpin, E. Rouillet, J. Stam, A. Wolters, M. R. Delgado, Eduardo Tolosa, G. Said, A. J. Lees, L. Rinaldi, A. Schulze-Bonhage, MA Ron, C. Lefebvre, E. W. Radü, R. Alvarez, M. L. Bots, P. Reganati, S. Palazzi, A. Poggi, N. J. Scolding, V. Sazdovitch, T. Moreau, E. Maes, M. A. Estelies, P. Petkova, Jose-Felix Marti-Masso, G De La Meilleure, N. Mullatti, M. Rodegher, N. C. Notermans, T. A. T. Warner, S. Aktan, J. P. Louboutin, L. Volpe, C. Scheidt, W. Aust, C. M. Wiles, U. Schneider, S. K. Braekken, W. R. Willems, K. Usuku, Peter M. Rothwell, C. Talamon, M. L. Sacchetti, A. Codina, M. H. Marion, A. Santoro, J. Roda, A. Bordoni, D. J. Taylor, S. Ertas, H. H. Emmen, J. Vichez, V. BesanÇon, R. E. Passingham, M. L. Malosio, A. Vérier, M. Bamberg, A. W. Hansen, E. Mostacero, G. Gaudriault, Marie Vidailhet, B. Birebent, K. Strijckmans, F. Giannini, T. Kammer, I. Araujo, J. Nowicki, E. Nikolov, A. Hutzelmann, R. Gherardi, J. Verroust, L. Austoni, A. Scheller, A. Vazquez, S. Matheron, H. Holthausen, J. M. Gerard, M. Bataillard, S. Dethy, V. H. Patterson, V. Ivanez, N. P. Hirsch, F. Ozer, M. Sutter, C. Jacomet, M. Mora, Bruno Colombo, A. Sarropoulos, T. H. Papapetropoulos, M. Schwarz, D. S. Dinner, N. Acarin, B. Iandolo, J. O. Riis, P. R. J. Barnes, F. Taroni, J. Kazenwadel, L. Torre, A. Lugaresi, I. L. Henriques, S. Pauli, S. Alfonso, Pedro Quesada, A. S. T. Planting, J. M. Castilla, Thomas Gasser, M. Van der Linden, A. Alfaro, E. Nobile-Orazio, G. Popova, W. Vaalburg, F. G. A. van der Mech, L. Williams, F. Medina, J. P. Vernant, J. Yaouanq, B. Storch-Hagenlocher, A. Potemkowski, R. Riva, M. H. Mahagne, M. Ozturk, Ve. Drory, N. Konic, C. Jungreis, A. Pou Serradell, J. L. Gauvrit, G. J. Chelune, S. Hermandez, T. Dingus, L. Hewer, Ch. Koch, M. N. Metz-Lutz, G. Parlato, M. Sinaki, Charles Pierrot-Deseilligny, H. C. Diener, J. Broeckx, J. Weill-Fulazza, M. L. Villar, M. Rizzo, O. Ganslandt, C. Duran, N. A. Fletcher, G. Di Giovacchino, Susan T. Iannaccone, C. Kolig, N. Fabre, H. A. Crockard, Rita Bella, M. Tazir, E. Papagiannuli, K. Overgaard, Emma Ciafaloni, I. Lorenzetti, F. Viader, P. A. H. Millac, I. Montiel, L. H. Visser, M. Palomar, P. L. Murgia, H. Pedersen, Rafael Blesa, S. Seddigh, W. O. Renier, I. Lemahieu, H. M. L. Jansen, L. Rosin, J. Galofre, K. Mattos, M. Pondal, G. M. Hadjigeorgiou, D. Francis, L. Cantin, D. Stegeman, M. Rango, A. B. M. F. Karim, S. Schraff, B. Castellotti, I. Iriarte, E. Laborde, T. J. Tjan, R. Mutani, D. Toni, B. Bergaasco, J. G. Young, C. Klotzsch, A. Zincone, X. Ducrocq, M. Uchuya, O. J. Kolar, A. Quattrone, T. Bauermann, Nereo Bresolin, J. Vallée, B. C. Jacobs, A. Campos, Werner Poewe, J. A. Villanueva, A. W. Kornhuber, A. Malafosse, E. Diez-Tejedor, G. Jungreia, M. J. A. Puchner, A. Komiyama, O. Saribas, V. Volpini, L. Geremia, S. Bressi, A. Nibbio, Timothy E. Bates, T. z. Tzonev, E. Ideman, G. A. Damlacik, G. Martino, G. Crepaldi, T. Martino, Kjell Någren, E. Idiman, D. Samuel, J. M. Perez Trullen, Y. van der Graaf, J. O. Thorell, M. J. M. Dupuis, E. Sieber, R. D'Alessandro, C. Cazzaniga, J. Faiss, A. Tanguy, A. Schick, I. Hoksergen, A. Cardozo, R. Shakarishvili, G. K. Wennlng, J. L. Marti-Vilalta, J. Weissenbach, I. L. Simone, Amalia C. Bruni, Darius J. Adams, C. Weiller, A. Pietrangeli, F. Croria, C. Vigo-Pelfrey, Patricia Limousin, A. Ducros, G. Conti, O. Lindvall, E. Richter, M. Zuffi, A. Nappo, T. Riise, J. Wijdenes, M. J. Fernandez, J. Rosell, P. Vermersh, S. Servidei, M. S. C. Verdugo, F. Gouttiere, W. Solbach, M. Malbezin, I. S. Watanabe, A. Tumac, W. I. McDonald, D. A. Butterfield, P. P. Costa, F. deRino, F. Bamonti, J. M. Cesar, C. H. Lahoz, I. Mosely, M. Starck, M. H. Lemaitre, K. M. Stephan, S. Tex, R. Bokonjic, I. Mollee, L. Pastena, M. Gutierrez, F. Boiler, M. C. Martinez-Para, M. Velicogna, O. Obuz, A. Grinspan, M. Guarino, L. M. Cartier, E. Ruiz, D. Gambi, S. Messina, M. Villa, Michael G. Hanna, J. Valk, Leone Pascual, M. Clanet, Z. Argov, B. Ryniewicz, E. Magni, B. Berlanga, K. S. Wong, C. Gellera, C. Prevost, F. Gonzalez-Huix, R. Petraroli, J. E. G. Benedikz, I. Kojder, C. Bommelaer, L. Perusse, M. R. Bangioanni, Guy M. McKhann, A. Molina, C. Fresquet, E. Sindern, Florence Pasquier, M. J. Rosas, M. Altieri, O. Simoncini, M. Koutroumanidis, C. A. F. Tulleken, M. Dary-Auriol, S. Oueslati, H. Kruyer, I. Nishisho, C. R. Horning, A. Vital, G. V. Czettritz, J. Ph. Neau, B. Mihout, A. Ameri, M. Francis, S. Quasthoff, D. Taussig, S. Blunt, P. Valentin, C. Y. Gao, O. Heinzlef, H. d'Allens, C. Coudero, M. Erfas, G. Borghero, P. J. Modrego Pardo, M. C. Patrosso, N. L. Gershfeld, P. A. J. M. Boon, O. Sabouraud, M. Lara, J. Svennevig, G. L. Lenzi, A. Barrio, H. Villaroya, JosÇ M. Manubens, O. Boespflug-Tanguy, M. Carreras, D. A. Costiga, J. P. Breux, S. Lynn, C. Oliveras Ley, A. G. Herbaut, J. Nos, C. Tornali, Y. A. Hekster, J. L. Chopard, J. M. Manubens, P. Chemouilli, A. Jovicic, F. Dworzak, S. Smirne, S. E. Soudain, B. Gallano, D. Lubach, G. Masullo, G. Izquierdo, A. Pascual Leone Pascual, A. Sessa, V. Freitas, O. Crambes, L. Ouss, G. W. Van Dijk, P. Marchettini, P. Confalonieri, M. Donaghy, A. Munnich, M. Corbo, and M. E. L. van der Burg
- Subjects
Neurology ,business.industry ,Media studies ,Library science ,Medicine ,Neurology (clinical) ,business - Published
- 1994
- Full Text
- View/download PDF
12. Diastolic heart failure: identification and characterization. The role of radionuclide ventriculography
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G, Cantinho
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Heart Failure ,Diastole ,Humans ,Gated Blood-Pool Imaging - Published
- 1999
13. 3.12WBR Versus FBP in Myocardial Perfusion SPECT Reconstruction: Diagnosis Impact
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G CANTINHO, H PENA, A VEIGA, A MARQUES, E FONSECA, S SHWARTZ, and F GODINHO
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Radiology, Nuclear Medicine and imaging ,Cardiology and Cardiovascular Medicine - Published
- 2007
- Full Text
- View/download PDF
14. Post-exercise electrocardiographic alterations, ST-segment elevation and QTc changes in patients with recent myocardial infarction
- Author
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M, Garcia-Alves, E, Macieira-Coelho, G, Cantinho, B B, da Costa, and A, Gouveia
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Male ,Electrocardiography ,Thallium Radioisotopes ,Exercise Test ,Myocardial Infarction ,Humans ,Female ,Gated Blood-Pool Imaging ,Prospective Studies ,Middle Aged ,Coronary Angiography ,Tomography, Emission-Computed - Abstract
Stress-induced ST-segment elevation and a prolongation or no change of the QTc ratio (corrected QT interval for heart rate) at maximal exercise in the infarct leads have been associated with the presence of residual myocardial ischemia in the infarct zone. The aim of this study was to test the agreement between stress-induced ST-segment elevation and post-exercise QTc changes in infarct leads, in 36 consecutive patients, studied by coronariography, radionuclide ventriculography and thallium-201 scintigraphy, within 3 months of the acute myocardial infarction. Sixteen patients (Group I) had exercise-induced ST-segment elevation in the infarct leads and 20 did not (Group II). The study showed no significant difference between severity of vessel disease and occlusion, prevalence of the infarct related artery or left ventricular dysfunction in Group I and II. No agreement between ST-segment shifts and myocardial perfusion in the infarct zone was found. Resting wall motion abnormalities were more severe in Group I than in Group II (p0.01). In the total of the 36 patients there was no agreement between ST-segment shifts and QTc-variations. The study showed agreement between QTc changes and myocardial perfusion in the infarct area (K = 0.64) (p0.001).This study showed no relation between post-exercise ST elevation and post-exercise QTc variations in Q wave leads. QTc variations at the end of exercise in the infarct related leads identified residual ischemia. Exercise ST segment elevation, although not a marker of ischemia, is associated with more severe wall motion abnormalities in the infarct zone.
- Published
- 1998
15. Technetium-99m labelling of the IOR CEA 1 monoclonal antibody: evaluation of different methods
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L, Gano, C, Fernandes, G, Cantinho, A I, Santos, H, Pena, R, Vieira, L, Salgado, and L, Patrício
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Antibodies, Monoclonal ,Technetium ,Carcinoembryonic Antigen ,Mice ,Drug Stability ,Radioimmunodetection ,Isotope Labeling ,Animals ,Regression Analysis ,Electrophoresis, Polyacrylamide Gel ,Female ,Indicators and Reagents ,Tissue Distribution ,Radiopharmaceuticals ,Mercaptoethanol - Abstract
The aim of this study was to investigate the in vivo and in vitro properties of 99mTc labelled monoclonal antibody, IOR CEA 1 when radiolabelled by different methods.To achieve that purpose IOR CEA was directly radiolabelled via 2-mercaptoethanol (2-Me) and stannous ion (SnCl2) reduction and indirectly via the 2-iminothiolane (2-Im) conjugation. The resulting 99mTc-MoAbs were analysed for number of free sulfhydryl groups, chemical and radiochemical purity (checked by HPLC and SDS PAGE), immunoreactivity and biological distribution in mice.Experimental results indicated a similar radiochemical purity and immunoreactivity for direct labelling methods and a decrease of both for 2-Im method. 2-Me antibody reduction led to a high antibody fragmentation as indicated by non-denaturing SDS PAGE analysis. Nevertheless SnCl2 and 2-Im labels revealed lower in vivo stability.99mTc-(2-Me) IOR CEA presented favorable in vitro and in vivo properties. Therefore this label was compared to 99mTc-monoclonal antibody BW 431/26. Similar characteristics were found. Clinical studies also revealed identical biodistribution profile.
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- 1997
16. [Coronary artery disease, myocardial perfusion and ventricular function in Q-wave and non-Q-wave myocardial infarcts]
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E, Macieira-Coelho, M, Garcia-Alves, B, da Costa, G, Cantinho, P, Pedro, I, Dionisio, A, Gouveia, and F, de Padua
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Adult ,Male ,Myocardial Infarction ,Myocardial Ischemia ,Coronary Disease ,Gated Blood-Pool Imaging ,Heart ,Middle Aged ,Coronary Angiography ,Electrocardiography ,Thallium Radioisotopes ,Exercise Test ,Humans ,Ventricular Function ,Female ,Aged - Abstract
Controversy remains in considering non-Q wave myocardial infarction (NQMI) a distinct pathophysiological entity of Q wave myocardial infarction (QMI). In order to analyze the severity of coronary artery disease, extension of myocardial scar or myocardial ischemia and ventricular function, 78 consecutive patients with QMI and 32 with NQMI, mean age 55.4 +/- 8.5, not submitted to thrombolytic therapy, were studied. Coronary angiography, exercise thallium scintigraphy and radionuclide ventriculography were performed in all at least within 3 months of a prior myocardial infarction. In the present study the occurrence of QMI was significantly more frequent in older patients than NQMI. There was no prevalence of occlusion either in the right, left circumflex or left anterior descending coronary arteries in both groups. Ejection fraction, degree of occlusion and presence of collateral circulation showed an equal prevalence in QMI and NQMI patients. A higher incidence of multivessel disease was found in NQMI that had less necrosis than QMI patients. The prevalence of exercise induced thallium-201 redistribution defects within the infarct zone was substantially higher and involved more scar segments in NQMI patients. Physiological and clinical consequences of coronary thrombosis depends on the size and the number of diseased arteries, the approach the pathophysiologic consequences of coronary disease in terms of fractal structure has been suggested. A pronounced heterogeneity in regional myocardial blood flow in a fractal branching arterial network may be responsible for the pathophysiologic differences of coronary thrombosis between Q-wave and non Q-wave infarction.
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- 1997
17. Wall motion abnormalities and late ventricular arrhythmia during the predischarge phase of acute myocardial infarction
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A L, Bordalo-Sá, M E, Sá, M J, Correia, G, Cantinho, A, Longo, L, Neves, R, Ferreira, J L, Tuna, and C, Ribeiro
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Adult ,Aged, 80 and over ,Male ,Time Factors ,Electrocardiography, Ambulatory ,Myocardial Infarction ,Humans ,Arrhythmias, Cardiac ,Female ,Gated Blood-Pool Imaging ,Middle Aged ,Aged - Abstract
Left ventricular wall aneurysm is a complication of acute myocardial infarction which has been considered a precipitating factor of cardiac failure and ventricular arrhythmia. We have evaluated the relation between severe left ventricular wall motion abnormalities and ventricular arrhythmia.During a two-year period 146 patients admitted to a coronary care unit with acute myocardial infarction were studied. Radionuclide angiography performed within the second and the fourth weeks was used to analyse phase and wall motility changes, and patients were divided into three groups: 1) Hypokinesia and/or akinesia localized to one segment: with no or slight changes in phase image--102 patients; 2) Aneurysm: left ventricular deformity with well-defined chromatic changes in phase image--19 patients; and 3) Dyskinesia and/or extensive akinesia of two or more segments: phase image with diffuse heterogeneous changes--25 patients. Ventricular arrhythmia was studied using Holter electrocardiography taken during the second week of acute myocardial infarction. Three rhythmic profiles were considered: no premature ventricular contractions--41 patients; with three or more than three premature ventricular contractions per hour--38 patients; repetitive premature ventricular contractions--20 patients.Premature ventricular contractions were absent in 31 (30%) of the patients with hypokinesia/localized akinesia vs 8 (42%) of the patients with aneurysm, and vs 2 (8%) of the patients with dyskinesia/extensive akinesia. Premature ventricular contractions were frequent (or = 3/h) in 22 (22%) of the patients with hypokinesia/localized akinesia vs 4 (21%) of the patients with aneurysm (p = 0.35; NS), and vs 12 (48%) of the patients with dyskinesia/extensive akinesia (p=0.003). Repetitive premature ventricular contractions were present in 10 (10%) of the patients with hypokinesia/localized akinesia vs 2 (11%) of the patients with aneurysm, and vs 8 (32%) of the patients with dyskinesia/extensive akinesia (p=0.008).We conclude that the presence of aneurysm was not associated with a higher occurrence of ventricular arrhythmia, but patients with dyskinesia/extensive akinesia had a higher occurrence of ventricular arrhythmia,or = 3 premature ventricular contractions per hour and repetitive premature ventricular contractions. Our results suggest that ventricular arrhythmia is related to functionally severe wall motion abnormalities, and not to anatomical discriminants. This finding leads us to suggest different electrophysiological mechanisms behind these two entities.
- Published
- 1995
18. [First-pass angiography. Methods]
- Author
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G, Cantinho
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Radioisotopes ,Ventriculography, First-Pass ,Data Collection ,Data Interpretation, Statistical ,Heart Septal Defects ,Humans - Published
- 1994
19. Minimal residual coronary obstructions in patients who suffered a first myocardial infarction. A prospective study comparing coronary angiography and exercise thallium scintigraphy
- Author
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Madalena Carvalho, I. Dionísio, António P. Lacerda, Mario Garcia-Alves, Eduardo Macieira-Coelho, Brás B. Da Costa, G Cantinho, and Fernando de Pádua
- Subjects
Adult ,Male ,medicine.medical_specialty ,Ischemia ,Myocardial Infarction ,chemistry.chemical_element ,Coronary Disease ,Constriction, Pathologic ,Scintigraphy ,Coronary Angiography ,Myocardial perfusion imaging ,Internal medicine ,medicine ,Humans ,cardiovascular diseases ,Myocardial infarction ,Prospective Studies ,Prospective cohort study ,Radionuclide Imaging ,Aged ,medicine.diagnostic_test ,business.industry ,Electrocardiography in myocardial infarction ,General Medicine ,Middle Aged ,medicine.disease ,Stenosis ,Thallium Radioisotopes ,chemistry ,cardiovascular system ,Cardiology ,Exercise Test ,Thallium ,Female ,Radiology ,Cardiology and Cardiovascular Medicine ,business - Abstract
The purpose of the present study was to correlate the presence of minimal coronary obstruction (< or = 50%) assessed by coronary angiography with the presence of myocardial scar and ischemia detected by thallium-201 myocardial perfusion imaging. The study included 83 consecutive patients (74 men and 9 women) with a mean age 55.4 +/- 8.5 years who suffered a first myocardial infarction and did not undergo thrombolytic therapy. In all patients, coronary angiography, left ventriculography, and exercise thallium-201 tomographic scintigraphy were performed within 3 to 5 months of the myocardial infarction. Coronary arteriograms showed minimal residual obstructions in 37 (45%) patients. Of a total of 54 patients with < or = 50% obstruction, 18 showed persistent defects and 22 reversible defects on thallium scintigrams. The present study showing estimated angiographic stenosis of < or = 50% as being responsible either for myocardial scar or myocardial ischemia on postexercise thallium scintigrams leads us to conclude that percent value of stenosis does not accurately predict the pathophysiologic significance of coronary atherosclerotic lesions in patients who suffer a myocardial infarction. After a first myocardial infarction, coronary angiographies and thallium-201 scintigrams are complementary for an optimal treatment strategy for selected subsets of patients.
- Published
- 1993
20. Postexercise changes of the QTc interval in patients with recent myocardial infarction
- Author
-
Mário Garcia-Alves, Eduardo Macieira-Coelho, I. Dionísio, F. de Pádua, G Cantinho, Fernando Sabino Marques Monteiro, M. Carvalho, and António P. Lacerda
- Subjects
Male ,medicine.medical_specialty ,Ischemia ,Myocardial Infarction ,Myocardial Ischemia ,chemistry.chemical_element ,Coronary Angiography ,QT interval ,Sensitivity and Specificity ,Coronary artery disease ,Electrocardiography ,Internal medicine ,medicine ,Humans ,In patient ,cardiovascular diseases ,Myocardial infarction ,Radionuclide Imaging ,Depression (differential diagnoses) ,business.industry ,Middle Aged ,medicine.disease ,Thallium Radioisotopes ,chemistry ,cardiovascular system ,Cardiology ,Exercise Test ,Thallium ,Female ,Cardiology and Cardiovascular Medicine ,business ,Perfusion - Abstract
A lack of the QTc ratio decrease at maximal exercise is considered as an index of exercise-induced ischemia in patients with coronary artery disease. The authors studied 51 patients with recent myocardial infarction in order to evaluate the QTc changes with exercise in assessing the presence of remaining ischemic myocardium. All patients were submitted to exercise stress tests, coronary angiographies, and exercise thallium 201 scintigraphies within 3–5 months of the myocardial infarction. Of the patients studied, 18 showed one-vessel disease and 33 showed multivessel disease. All vessels were classified as patent or occluded. In all patients with reversible thallium 201 defects both at distance and in the infarct zone, the QTc interval following exercise either showed a prolongation or no change from the resting electrocardiogram. In patients with only fixed perfusion defects, the QTc shortened at the end of the test. This study showed a low sensitivity and specificity for inducible ST-segment depression compared with the delayed redistribution on the postexercise thallium 201 scintigram. QTc variations at the end of exercise electrocardiograms are valuable as a noninvasive, low-cost identification of residual ischemic myocardium in patients after myocardial infarction.
- Published
- 1993
21. [Significance exercise-induced ST elevation in patients with myocardial infarction]
- Author
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M, Carvalho, G, Cantinho, A P, de Lacerda, I, Dionísio, B B, da Costa, M G, Alves, F, De Pádua, and E, Macieira-Coelho
- Subjects
Male ,Electrocardiography ,Exercise Test ,Myocardial Infarction ,Humans ,Female ,Gated Blood-Pool Imaging ,Middle Aged ,Coronary Angiography - Abstract
In 52 patients with previous myocardial infraction, 49 men and 3 women (mean age 56 +/- 7.1 years) the significance of ST-segment elevation during the stress-test, was evaluated. Of the 52 patients 15 (29%) showed St-segment elevation and 37(71%), showed no alteration of the ST-segment. Extension of coronary disease, degree of obstruction, wall motion abnormalities and the presence of residual ischemia were evaluated by coronary angiography, technetium-99M pyrophosphate imaging and exercise TL-201 scintigraphy. From the results of the study one may conclude that, in patients with previous myocardial infraction exercise, ST-segment elevation is a consequence of sub-occlusion of the left anterior descending coronary artery with severe ventricular dysfunction either in patients with one or multiple vessel disease.
- Published
- 1993
22. [Equilibrium radionuclide angiography in patients with previous myocardial infarct. Correlation with electrocardiogram and coronarography]
- Author
-
E, Macieira-Coelho, M, Carvalho, I, Dionísio, A, Prudêncio, J A, da Cunha, and G, Cantinho
- Subjects
Male ,Electrocardiography ,Time Factors ,Myocardial Infarction ,Humans ,Female ,Gated Blood-Pool Imaging ,Middle Aged ,Coronary Angiography ,Myocardial Contraction - Abstract
Fifty five patients with previous myocardial infarction (MI), 47 male and 8 female, mean age 55.5 +/- 8.9 years, have been studied in order to correlate the alterations found on the equilibrium (gated) radionuclide angiogram (RNA) with the location of the MI on the electrocardiogram of the obstructive lesions on coronary angiographies. Of the 55 patients studied, 22% showed no regional wall motion abnormalities (WMA). Both MI with and without Q wave may show WMA, which are significatively more frequent in patients with anterior MI on the ECG and with occlusive lesions (greater than 90%) on coronariographies. Regional localization of the WMA on the RNA does not identify the localization of the obstructive lesions. Hypokinesia was the most frequent type of WMA found both with occlusive (greater than 90%) and sub-occlusive (greater than 75%) lesions. Low values of the ejection fraction (less than 45%) were found in the presence of WMA and occlusive artery lesions.
- Published
- 1990
23. 3.11Wide Beam Reconstruction Technology: Does It Respect Myocardial Perfusion SPECT Functional Parameters?
- Author
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H PENA, G CANTINHO, S SHWARTZ, S FIGUEIREDO, D MARONA, J MONTEIRO, and F GODINHO
- Subjects
Radiology, Nuclear Medicine and imaging ,Cardiology and Cardiovascular Medicine - Published
- 2007
- Full Text
- View/download PDF
24. 7.4Wide beam reconstruction technology - Does it respect myocardial perfusion SPECT functional parameters?
- Author
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L. Pereira, J. Monteiro, S.C. Shwartz, F. Godinho, D. Cerqueira, G. Cantinho, and H. Pena
- Subjects
business.industry ,Medicine ,Radiology, Nuclear Medicine and imaging ,Cardiology and Cardiovascular Medicine ,business ,Nuclear medicine ,Perfusion ,Beam (structure) - Published
- 2007
- Full Text
- View/download PDF
25. 1.56WBR versus FBP in myocardial perfusion SPECT reconstruction - Diagnosis impact
- Author
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S.C. Shwartz, Alvaro Veiga, F. Godinho, G. Cantinho, H. Pena, E. Fonseca, and A.V. Marques
- Subjects
medicine.medical_specialty ,business.industry ,Medicine ,Radiology, Nuclear Medicine and imaging ,Radiology ,Cardiology and Cardiovascular Medicine ,business ,Nuclear medicine ,Perfusion - Published
- 2007
- Full Text
- View/download PDF
26. Exercise testing for assessment of autonomic dysfunction in patients with familial amyloidotic polyneuropathy type I
- Author
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C Azevedo Coutinho, G Cantinho, MJ Correia, I Concei????o, MG Varela, AR Victor, A Bernardes, A Silva, and MG Lopes
- Subjects
medicine.medical_specialty ,Epidemiology ,business.industry ,Internal medicine ,medicine ,In patient ,Cardiology and Cardiovascular Medicine ,medicine.disease ,business ,Polyneuropathy - Published
- 2006
- Full Text
- View/download PDF
27. The influence of combined therapy with perindopril and trimetazidine on the silent myocardial ischemia and on left ventricular remodeling in essential hypertension
- Author
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H. Otani, K. Sugi, W. Tracz, B. Alvarez, L. M. Hamburg, S. K. H. Vatinyan, K. Kida, U. Schurr, M. Polimeno, Philipp A. Kaufmann, L. B. Edilyan, O. Infante, A. Amalia Peix, F. Del Dottore, I. Idy-Peretti, K. Itoh, Yuko Kawai, J. McGhie, K. Moser, Efstratios Moralidis, Marvin Friedman, M. A. Quin ones, Emre Entok, W. Watanabe Yasuhi, J. Sugioka, J. Duch, M. Sliwinski, E. Clark, Tatsuhiko Furuhashi, V. Naylor, R. Lebtahi, L. Llerena, Ryo Nakazato, B. G. Chobanyan, F. Mut, L. Poirier, M.B. Al-Housni, L. L. Mont, F. Porta-Biosca, F. Tassone, C Lourenço, R. V. Ramanathapuram Parameswaran, A. Bianchi, I. Henriksson, J. Orus, A. Africa Muxi, J. Trebacz, P. Colarinha, Shung Chull Chae, H. Ben Brahim, Shigeru Fukuzawa, P. Klimeczek, F. Tornes, Alberto Cuocolo, S. V. Svetlana Gurgenyan, M. Merlano, L. O. Cabrera, H. Lee, I. Irena Peovska, K. Keiko Takahashi, K. Tanabe, S. Kumar, M. Ferreira, T. Matsumoto, N. Fritsch, S. Okuda, A. Bernardes, T. Spyridonidis, P. Paredes, K. B. Lee, A. Silva, C. Côté, I. D’Aragona, A. Francini, B. Paghera, Tomohiro Kaneta, John D. Friedman, Gurusher Panjrath, H. Jino, H. E. Grassos, N. Hashimoto, Y. Mori, Paul B. Kavanagh, D. D. Kontogianni, K. Inoue, Y. Ohta, M. Chiariello, D. Polepalle, S. Dellegrottaglie, Yuksel Cavusoglu, Aloha Meave, Fiona Hutchings, J. Reynolds, M. Pasowicz, A. Kazmierczak, G. P. Perna, D. Pop Gorceva, M. J. Correia, Alessia Gimelli, J. Park, Randall C. Thompson, J. Ortin, S. Oshima, H. Yoshino, K. Won, B. Szumilak, G. A. J. Riegger, Cigdem Akincioglu, L. S. Maffioli, B. Mahmoudian, K. Kawasaki, E. Nariaki, U. Uzodinma Dim, S. Peano, G. Cantinho, P. Pieniazek, A. De Paz, B. Shim, June-Key Chung, E. Diaz-Infante, Bilgin Timuralp, A. Ana Abreu, Patrick T. Siegrist, J. Pietrzykowski, P. Birkbeck, Hidetaka Nishina, N. Teramoto, G. Kabakcý, Alejandro Ricalde, M. Negre-Buso, J. Lefebvre, P. Wilkolek, N. Karatzas, L. A. Providência, A. Benada, C. Eilles, E. Milan, D. Speiser, K. Karakatsanis, Mitsumasa Ohyanagi, K. Aytemir, M. C. Maria Azevedo Coutinho, T. Kanemori, Muhammad Raza, G. Valle, A. Terzi, P. Bertelli, Guido Germano, L. Thompson, M. Yamazaki, A. K. Padhy, K.J. Nichols, G. Romero-Farina, Norbert Heinicke, M. Feola, H. Khattak, I. Guerrero, S. Kahraman, M. Santomauro, F. Gaspar, J. A. Correia da Cunha, Minoru Horie, T. Sekine, N. Bartenstein, I. Conceição, R. Seki, Santiago Aguadé-Bruix, M. Mazzanti, J. Kropp, D Le Guludec, Mirosław Dziuk, R. Hassad, A. P. Caresia, M. Dumont, P. Pifarre-Montaner, M. Serenelli, S. Akihiro, E. Pereira, V. Vikas Jindal, A. Mestre-Fusco, M. Agostini, S. Holmer, A. Geão, M. Cholewa, S. Padma, C. Coaguila, M. Stanislao, C. Hædersdal, J. Maksimovic Pavlovic, L. Rosário, M. Meltem Caglar, C. Roque, M. Schindel, D. Kawasaki, M. Arýcý, J.P. Hellermann, J. Valiente, P. Hendzel, A. Zarrilli, D. Vilain, M. Cafiero, F. Miyake, T. Hackney, S. Hinton-Taylor, Ichiro Nakae, M. Feldkamp, N. Isobe, T. M. Bateman, G. S. Goranitou, L. Pace, I. Silvasi, F. Bertagna, A Teresińska, Pasquale Perrone Filardi, A. Kusch, E. Kot, A. Trapaga, A. Luchner, Gordon DePuey, D. Garcia-Barreto, G. Hong, M. Inagaki, K.K. Haridas, M. Zachariah, Miho Masai, C. Marini, I. Butti, V. Mouradian, O. Alonso, J. Lima, L. Piatti, I. Ihnho Cho, I. Vidal, K. Shimoyama, T. Hayashi, T. Kimio, E. Karabulut, D. Jain, J. Vacek, R. Zayas, I. H. Chae, Palaniswamy Shanmuga Sundaram, E. Papoulia, M. Vavlukis, Erick Alexanderson, W. Yasunori, A. Cheetham, J. Castro, Pascal Koepfli, W. Szot, E. Vardareli, K. Ryu, Assuero Giorgetti, F. Pons, A. Ferro, T. Kaiser, E. Casorelli, Doumit Daou, Mario Beretta, L. Asen, T. Przewlocki, I. Komuro, A. Biggi, S. Fuertes, F. Ponce, S. Konieczna, Daniel S. Berman, J. Candell-Riera, L. Castillejos, J. Castell-Conesa, Shin Young Jeong, Rolf Jenni, L. Corrado, K. M. Kyeong Min Kim, Luigia Florimonte, D. K. Babalis, M. Namdar, K. G. Nikogosyan, A. Yukawa, Masao Moroi, J. Jae-Tae Lee, K. Nakazawa, Sean W. Hayes, A. Yang, J. Schönberger, S. Thatikonda, Byeong-Cheol Ahn, J. H. Seo, S. Shinro Matsuo, E. M. Kalkandi, H. Watabe, E. Uslenghi, Y. Lacourcière, H. Hoshizaki, Y. Kim, Takuji Toyama, R. Pepino, Z. Juraszynski, G. De Leon, T. Thomas Rosamond, M. Seegmüller, A. Haider, Nikos T. Kouris, A. Nagae, M. D. Sifaki, T. Shigeyama, P. Marzullo, R. Camerino, H. Fukuda, H. Hamami, K. Zmudka, M. Nuñez, D. Shin, A. I. McGhie, A. Leenhardt, Yoshihiro J. Akashi, T. Tohru Nishimura, D. Masuda, K. Snyder, P. Dutto, A. Ferrer-Antunes, G. Gentili, E. Guala, L. Oliveira, P.L Pieri, M. Pieculewicz, M. Mila-Lopez, G. Leonardi, S. Ozawa, Olakunle O. Akinboboye, R. Giubbini, P. Zanco, C. Gutierrez, A. Sellem, H. Iida, T. Kunimasa, E. Inglese, Y. Yoshitomo Mori, T. Hakamatsuka, K. Morishima, C. Garcia-Alonso, H. Musha, L. Pagani, K. Taniguchi, C. Duilio, G. Bosio, S. Okino, Jesper Mehlsen, R. Carrillo, C. Pollack, M. Szymanska, Y. Fayad, Magdalena Kostkiewicz, Piotr J. Slomka, J. H. O’Keefe, C. Onsel, T. Yasuhiko, V. Majstorov, R. Schumacher, A. Gimelli, O. Garrone, K. Chun, K. Keiichi Nakagawa, M. Schluter, G. Arsos, A. Kelion, J. H. Bae, M. Occelli, A. Maglione, Keiko Takahashi, F. Ghiotto, A. Debski, A. Rener, P. Podolec, M. Salvatore, R. Kawaguchi, and B. Benesch
- Subjects
medicine.medical_specialty ,business.industry ,Medicine ,Radiology, Nuclear Medicine and imaging ,Medical physics ,Cardiology and Cardiovascular Medicine ,business - Published
- 2005
- Full Text
- View/download PDF
28. Left arm position - effect of attenuation correction on myocardial tracer distribution
- Author
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F. Godinho, V Marques, H. Pena, Alvaro Veiga, and G. Cantinho
- Subjects
Distribution (number theory) ,business.industry ,TRACER ,Medicine ,Radiology, Nuclear Medicine and imaging ,Cardiology and Cardiovascular Medicine ,Geodesy ,business ,Correction for attenuation ,Arm position - Published
- 1999
- Full Text
- View/download PDF
29. 14. Evaluation of pulmonary epithelial permeability (PEP) in sarcoidosis
- Author
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G. Cantinho, E. M. Leite, M. F. e Costa, F. Godinho, A. I. Santos, T. Martins, Araújo A, and A. Mendes
- Subjects
Pathology ,medicine.medical_specialty ,business.industry ,Medicine ,Radiology, Nuclear Medicine and imaging ,General Medicine ,Epithelial permeability ,Sarcoidosis ,business ,medicine.disease - Published
- 1996
- Full Text
- View/download PDF
30. Segmental viability after myocardial infarction evaluated by Thallium-201 reinjection with patency vessel angiography and echo-dobutamine correlation
- Author
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J.S. Nogueira, Luís, H. Morais, Ana Aleixo, C. Fonseca, G. Cantinho, and A. Sales
- Subjects
medicine.medical_specialty ,medicine.diagnostic_test ,business.industry ,Echo (computing) ,chemistry.chemical_element ,medicine.disease ,chemistry ,Internal medicine ,Angiography ,medicine ,Cardiology ,Thallium ,Radiology, Nuclear Medicine and imaging ,Dobutamine ,Myocardial infarction ,Cardiology and Cardiovascular Medicine ,business ,medicine.drug - Published
- 1995
- Full Text
- View/download PDF
31. Myoview for rest/stress myocardial SPECT within 2 hours. A Spanish-Portuguese multicenter trial
- Author
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J. A. Jurado, M. Perezcastejon, A. Ventosa, G. Cantinho, E. Esplugues, M. J. Tabuenca, J. Martin-Comin, A. T. Fonseca, L. Salgado, and R. Montz
- Subjects
medicine.medical_specialty ,business.industry ,Multicenter trial ,Stress (linguistics) ,language ,Physical therapy ,Medicine ,Radiology, Nuclear Medicine and imaging ,Portuguese ,Cardiology and Cardiovascular Medicine ,business ,language.human_language ,Rest (music) - Published
- 1995
- Full Text
- View/download PDF
32. Left ventricular volume calculation automated technique applied to multigated radionuclide angiography
- Author
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G. Cantinho and F. Godinho
- Subjects
Radionuclide angiography ,medicine.diagnostic_test ,business.industry ,medicine ,Ventricular volume ,Radiology, Nuclear Medicine and imaging ,Cardiology and Cardiovascular Medicine ,Automated technique ,business ,Nuclear medicine - Published
- 1995
- Full Text
- View/download PDF
33. Significance of stress test ST elevation in patients with myocardial infarction
- Author
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Braz Bruto da Costa, Eduardo Macieira-Coelho, M. Carvalho, M G Alves, G Cantinho, F. Pádua, António P. Lacerda, and I. Dionísio
- Subjects
medicine.medical_specialty ,Stress test ,business.industry ,Internal medicine ,ST elevation ,medicine ,Cardiology ,In patient ,Myocardial infarction ,Cardiology and Cardiovascular Medicine ,medicine.disease ,business - Published
- 1992
- Full Text
- View/download PDF
34. Postexercise changes of the QTc interval patients with recent myocardial infarction
- Author
-
Mário Garcia-Alves, M. Carvalho, A.P. Lacerda, I. Dionísio, F. Monteiro, G. Cantinho, E. Macieira-Coelho, and F. de Pádua
- Subjects
Cardiology and Cardiovascular Medicine - Published
- 1992
- Full Text
- View/download PDF
35. Primary chemotherapy with mitoxantrone and prednisone in advanced breast carcinoma. A phase II study
- Author
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E. Henriques, A. Sales-Luis, Fátima Godinho, F. Oliveira Costa, J. Carmo-Pereira, and M. G. Cantinho-Lopes
- Subjects
Adult ,medicine.medical_specialty ,Urology ,Phases of clinical research ,Breast Neoplasms ,Prednisone ,Antineoplastic Combined Chemotherapy Protocols ,medicine ,Carcinoma ,Humans ,Mitoxantrone ,Cardiotoxicity ,Ejection fraction ,business.industry ,Cumulative dose ,Stroke Volume ,Leukopenia ,Middle Aged ,medicine.disease ,Surgery ,Oncology ,Drug Evaluation ,Female ,business ,Breast carcinoma ,medicine.drug - Abstract
Thirty-seven evaluable patients with progressive disseminated breast carcinoma were treated with a combination of mitoxantrone 14 mg/m2 i.v. every 3 weeks plus prednisone 20 mg/m2 p.o. daily with a reducing dose over several weeks. Thirteen of 37 patients (35%) achieved an objective response with two complete regressions. The median duration of response was 7 months and the median duration of survival 14 months. The cardiac function of all patients was monitored by serial left ventricular ejection fraction, at rest and after stress, and 3-monthly thereafter. Ten patients showed a deterioration in the ejection fraction after a minimum cumulative dose of 86 mg/m2 (six cycles), but only four developed clinical cardiac failure which was easily reversible after stopping mitoxantrone. Leucopenia was the dose-limiting toxicity. Nausea and/or vomiting were generally mild and transient. Alopecia was minimal. These results confirmed that this combination is effective and well tolerated in the treatment of disseminated breast carcinoma, and cardiotoxicity can be avoided with adequate monitoring of the left ventricular ejection fraction after six cycles of therapy (86 mg/m2).
- Published
- 1988
- Full Text
- View/download PDF
36. A comparison of two doses of adriamycin in the primary chemotherapy of disseminated breast carcinoma
- Author
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Fátima Godinho, M. G. Cantinho-Lopes, J. Carmo-Pereira, A. Sales-Luis, F. O. Costa, Elivra Henriques, and Robert D. Rubens
- Subjects
Adult ,Cancer Research ,medicine.medical_specialty ,Time Factors ,medicine.medical_treatment ,Breast Neoplasms ,Gastroenterology ,Drug Administration Schedule ,Random Allocation ,Internal medicine ,medicine ,Carcinoma ,Humans ,Doxorubicin ,Aged ,Chemotherapy ,Clinical Trials as Topic ,Ejection fraction ,business.industry ,Cancer ,Middle Aged ,medicine.disease ,Surgery ,Regimen ,Oncology ,Heart failure ,Female ,Breast carcinoma ,business ,medicine.drug ,Research Article - Abstract
Forty-eight patients with advanced breast carcinoma who had not received prior chemotherapy (minimum follow up 21 months) were randomised to receive either adriamycin 70 mg m-2 i.v. 3-weekly for 8 cycles (Regimen A) or adriamycin 35 mg m-2 i.v. 3-weekly for 16 courses (Regimen B). Objective responses were seen in 14/24 (58%) patients with regimen A (4 complete) and 6/24 (25%) with regimen B (1 complete) (P less than 0.02). The median duration of response was 14 months with regimen A and 6.5 months with regimen B. The median duration of survival was 20 months and 8 months respectively (P less than 0.01). The toxicity was similar with each regimen. There was no evidence of deterioration in left ventricular ejection fraction nor congestive heart failure in any patient. It is concluded that when given at 3-weekly intervals adriamycin is a more effective treatment for advanced breast cancer at higher rather than lower dosage.
- Published
- 1987
37. [Surgical treatment of variant angina. Apropos of a clinical case]
- Author
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M E, Prazeres de Sá, A L, Bordalo e Sá, J A, Correia da Cunha, R, de Lima, G, Cantinho, C, Delgado, J T, Soares-Costa, and C, Ribeiro
- Subjects
Angina Pectoris, Variant ,Male ,Electrocardiography ,Electrocardiography, Ambulatory ,Humans ,Isosorbide Dinitrate ,Aged - Abstract
A case of a male 66 years-old patient who presented with a clinical picture of Prinzmetal's variant angina early in the evolution of an acute myocardial infarction is reported. Transient elevation of ST-segment was documented on Holter monitoring in association with angina at rest as well as asymptomatic episodes of ST-segment changes. Significant two-vessels obstructive lesions (left anterior descending and circumflex arteries) was present. As variant angina had several recurrences in spite of medical therapy with nitrates and calcium antagonists, the patient was submitted to coronary by-pass surgery associated to plexectomy. A Thallium myocardial scintigraphy suggests that a peroperative infarction had occurred. The patient was asymptomatic at six months follow-up.
- Published
- 1989
38. [Early left ventricular dysfunction in acute myocardial infarct. Evaluation using imaging methods]
- Author
-
R, Ferreira, A, Araújo, G, Cantinho, R, de Lima, B B, da Costa, F, Pais, P, Monteiro, J, Cravino, F, Godinho, and C, Ribeiro
- Subjects
Male ,Echocardiography ,Heart Ventricles ,Myocardial Infarction ,Humans ,Pulmonary Edema ,Heart Aneurysm ,Middle Aged ,Radionuclide Angiography - Abstract
A patient admitted in a Coronary Care Unit with an acute anterior myocardial infarction, is presented. He had initially normal left ventricular function and, on the 11th day he had, suddenly, an acute pulmonary edema. The reason for this episode was detected through imaging techniques--echocardiography and isotopic studies, and consisted on infarct expansion with early evolution for apical aneurysm. Contrast angiography confirmed the presence of a huge aneurysm and two vessels disease. Tallium Scintigraphy showed reversible ischemia beyond necrotic areas. The patient was submitted to aneurysmectomy and received three aorto-coronary bypass. He is now doing well, in class I, NYHA. The discussion emphasizes the actual role of imaging techniques in the diagnosis of infarct expansion and early functional aneurysm. We discuss the prognostic of infarct expansion and the importance of perfusion studies on defining areas of myocardium in jeopardy, enabling a better surgical approach.
- Published
- 1989
39. [Comparison of Holter electrocardiography and thallium 201 scintigraphy in the detection of myocardial ischemia]
- Author
-
M J, Correia, J R, Rebelo, G, Cantinho, L, Botas, A, Longo, J, dos Remédios, A P, Machado, J L, Tuna, R, Ferreira, and F, Godinho
- Subjects
Adult ,Male ,Thallium Radioisotopes ,Electrocardiography, Ambulatory ,Exercise Test ,Humans ,Coronary Disease ,Female ,Middle Aged ,Radionuclide Imaging ,Aged - Abstract
To compare ischemic changes (I) detected by Holter ECG (H ECG) to the myocardial perfusion defects found in 201 TI myocardial perfusion scintigraphy.201 TI exercise test was made during the performance of a 24 hours H ECG. The validation of ST segment changes detected by H ECG during the exercise test was made on basis of reversible myocardial perfusion defects (RPD) detected on 201 TL and a relation between ST segment changes detected during the remaining 24 hours recording period and 201 TI (TI) RPD was established.The patients (pt) included in the study have come from Cardiology and Heart Surgery Clinics of a Central teaching hospital.20 pt with a high coronary artery disease prevalence have been submitted to a two lead (V5 and aVF) 24 hour H ECG during which they have performed a symptom limited bicycle exercise test followed by an injection of 201 TI with acquisition 5 minutes later. Ischemic episodes detected on H ECG were quantified and their relation with heart rate and symptoms was established. As far as 201 TI studies are concerned the fixed and reversible perfusion defects as well as their location were evaluated.1. H ECG: 6 pt (30%) presented ST changes on H ECG during the exercise test and a total of 9 pt (45%) had ST changes during exercise and during the remaining period of H ECG. 2. TI: 19 pt presented perfusion defects images (fixed in 7, reversible in 14, both kinds of defects in 7). 3. H ECG validation: H ECG during exercise presented I in 6 out of 14 pt with RPD on TI (sensitivity = 43%). Six of these 8 pt, with negative H and positive TI, had a chronic myocardial infarction. All the 6 pt with negative TI had negative H ECG (specificity = 100%). 4. H ECG TI comparison: 7 (50%) of the 14 pt with RPD had ST changes on 24 hrs H ECG. Seven of 11 pt with negative H ECG had RPD in TI. Two pt with negative TI had positive H ECG. These 2 pt had during H ECG a higher heart rate (HR) than the HR recorded during the exercise test.1. In pt with known CAD, TI has a high sensitivity and specificity to show perfusion defects. 2. Considering TI as gold standard, H ECG showed to be a useful method to detect I in the studied population (sens. = 43%; spec. = 100%). 3. H ECG revealed to be an important diagnostic tool in detecting additional I episodes beyond the ones recorded during TI exercise test.
- Published
- 1989
40. Diagnostic and prognostic contribution of DPD scintigraphy in transthyretin V30M cardiac amyloidosis.
- Author
-
Azevedo Coutinho MC, Cortez-Dias N, Cantinho G, Gonçalves S, Cunha N, Rodrigues T, Santos L, Conceição I, Agostinho J, and Pinto FJ
- Subjects
- Male, Humans, Middle Aged, Female, Prognosis, 3-Iodobenzylguanidine, Prealbumin genetics, Radionuclide Imaging, Amyloid Neuropathies, Familial diagnostic imaging, Amyloid Neuropathies, Familial genetics, Cardiomyopathies diagnostic imaging, Cardiomyopathies genetics
- Abstract
Background: Early diagnosis and prognostic stratification of cardiac transthyretin amyloidosis are crucial. Although
99m Tc 3,3-diphosphono-1,2-propanedicarboxylic acid (DPD) scintigraphy is the preferred method for the non-invasive diagnosis, its accuracy appears to be limited in transthyretin amyloidosis protein (ATTR) V30M mutation. Furthermore, its prognostic value in this mutation is unknown. This study investigated the diagnostic value of DPD scintigraphy to detect ATTR cardiomyopathy in V30M mutation and explored its prognostic value regarding mortality., Methods: A total of 288 ATTR V30M mutation carriers (median age: 46 years; 49% males) without myocardial thickening (defined as septal thickness ≥13mm) attributable to other causes and who underwent DPD scintigraphy were enrolled. ATTR cardiomyopathy was defined by septal thickness ≥13mm and at least one of the criteria: late heart-to-mediastinum (H/M)123 I-metaiodobenzylguanidine (MIBG) uptake ratio <1.60; electrical heart disease or biopsy-documented amyloidosis., Results: ATTR cardiomyopathy was identified in 41 (14.2%) patients and cardiac DPD uptake in 34 (11.8%). During a mean follow-up of 33.6 ± 1.2 months, 16 patients died (5.6%). Mortality was 14 times higher in patients with ATTR cardiomyopathy, 13 times higher in those with DPD uptake and 10 times higher in those with late H/M MIBG <1.60. The combined assessment of septal thickness and cardiac DPD uptake improved risk stratification: patients without septal thickening and without DPD retention had an excellent prognosis while those who presented either or both of them had a significantly worse prognosis, with 5-year mortality rates ranging from 39.9 to 53.3%., Conclusions: DPD scintigraphy is useful for prognostic stratification of ATTR V30M mutation carriers. Patients without septal thickening and no DPD uptake present the best prognosis compared to those with any signs of cardiac involvement.- Published
- 2024
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41. A Case of Success: Complete Response to Radium-223 in Metastatic Castration-Resistant Prostate Cancer.
- Author
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Soares de Pinho I, Esperança-Martins M, Machado B, Dâmaso S, Lopes Brás R, Cantinho G, Fernandes I, and Costa L
- Abstract
Radium-223 dichloride (Ra223) is the first targeted alpha agent approved for treating metastatic castration-resistant prostate cancer (mCRPC) with bone-exclusive disease. A benefit in overall survival and time to the first symptomatic skeletal-related event was shown in the Alpharadin in Symptomatic Prostate Cancer Patients (ALSYMPCA) trial. However, this trial did not describe a bone scan response to Ra223, and there is no universal consensus about how it should be monitored. Furthermore, a scintigraphy flare phenomenon may lead to false-positive tracer uptake in responsive cases, thereby misleading the interpretation of imaging results. We present the case of a 67-year-old male with mCRPC and exclusive bone disease treated with Ra223. The bone scintigraphy after the end of the treatment showed an apparent aggravation of the lesions, corresponding to a flare phenomenon, with an almost complete resolution after three months. The patient maintained a scintigraphic response for seven months., Competing Interests: The authors have declared that no competing interests exist., (Copyright © 2024, Soares de Pinho et al.)
- Published
- 2024
- Full Text
- View/download PDF
42. The sensitivity of DPD scintigraphy to detect transthyretin cardiac amyloidosis in V30M mutation depends on the phenotypic expression of the disease.
- Author
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Azevedo Coutinho MC, Cortez-Dias N, Cantinho G, Gonçalves S, Menezes MN, Guimarães T, Lima da Silva G, Francisco AR, Agostinho J, Santos L, Conceição I, and Pinto FJ
- Subjects
- Adamantane administration & dosage, Adamantane analogs & derivatives, Adult, Amyloid Neuropathies, Familial genetics, Amyloid Neuropathies, Familial pathology, Blood Pressure Monitoring, Ambulatory, Female, Genetic Variation genetics, Heart drug effects, Heart physiopathology, Humans, Male, Middle Aged, Mutation genetics, Myocardium pathology, Prealbumin isolation & purification, Amyloid Neuropathies, Familial diagnosis, Myocardium metabolism, Prealbumin genetics, Radionuclide Imaging
- Abstract
Background: There is a growing need for a non-invasive test to detect cardiac involvement in patients with transthyretin-related hereditary amyloidosis (ATTR) caused by V30M mutation.
99m Tc-3,3-diphosphono-1,2-propanodicarboxylic acid (DPD) scintigraphy is a promising method, but its accuracy in this particular mutation remains unknown. Methods: A cohort of 179 patients: 92 with early-onset disease (EoD, symptoms <50-years-old), 33 with late-onset disease (LoD) and 54 asymptomatic carriers were prospectively evaluated and underwent DPD scintigraphy, which was compared with the results of echocardiogram, ambulatory blood pressure monitoring, 24 h-Holter, myocardial123 I-metaiodobenzylguanidine imaging and NT-proBNP. Results: Amyloid cardiomyopathy, defined as septal thickness ≥13 mm, was present in 32 patients (17.9%) and was more frequent in those with LoD (OR: 3.68, p = .003). Cardiac DPD uptake was present in 22 individuals (12.3%) and correlated with parameters indicative of cardiac amyloidosis. DPD imaging was strongly influenced by the age of disease onset: among patients with myocardial thickening, cardiac DPD retention was present in 11/15 (73.3%) with LoD, in contrast to only 4/17 (26.7%) with EoD ( p = .005). Two patients with myocardial thickening and normal DPD scintigraphy underwent endomyocardial biopsy that confirmed ATTR amyloidosis. Conclusion: DPD scintigraphy presents suboptimal sensitivity to detect cardiac involvement in ATTRV30M, particularly in symptomatic patients with EoD.- Published
- 2020
- Full Text
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43. Progression of myocardial sympathetic denervation assessed by 123 I-MIBG imaging in familial amyloid polyneuropathy and the effect of liver transplantation.
- Author
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Azevedo Coutinho MDC, Cortez-Dias N, Cantinho G, Conceição I, Guimarães T, Lima da Silva G, Nobre Menezes M, Francisco AR, Plácido R, and Pinto FJ
- Subjects
- Adult, Autonomic Nervous System Diseases etiology, Cardiomyopathies etiology, Disease Progression, Female, Humans, Male, Middle Aged, Radionuclide Imaging, 3-Iodobenzylguanidine, Amyloid Neuropathies, Familial complications, Autonomic Nervous System Diseases diagnostic imaging, Autonomic Nervous System Diseases prevention & control, Cardiomyopathies diagnostic imaging, Cardiomyopathies prevention & control, Liver Transplantation, Radiopharmaceuticals
- Abstract
Introduction: Familial amyloid polyneuropathy (FAP) is a rare disease caused by systemic deposition of amyloidogenic variants of the transthyretin (TTR) protein. The TTR-V30M mutation is caused by the substitution of valine by methionine at position 30 and mainly affects the peripheral and autonomic nervous systems. Cardiovascular manifestations are common and are due to autonomic denervation and to amyloid deposition in the heart. Cardiac sympathetic denervation detected by iodine-123 labeled metaiodobenzylguanidine (MIBG) is an important prognostic marker in TTR-V30M FAP. Liver transplantation, widely used to halt neurological involvement, appears to have a varying effect on the progression of amyloid cardiomyopathy. Its effect on the progression of cardiac denervation remains unknown., Methods: In this observational study, patients with the TTR-V30M mutation underwent annual cardiac assessment and serial MIBG imaging with quantification of the late heart-to-mediastinum (H/M) ratio., Results: We studied 232 patients (median age 40 years, 54.7% female, 37.9% asymptomatic at the time of inclusion) who were followed for a median of 4.5 years and underwent a total of 558 MIBG scans. During follow-up, 47 patients (20.3%) died. MIBG scintigraphy at inclusion was a strong predictor of prognosis, with the risk of death increasing by 27.8% for each one-tenth reduction in the late H/M ratio. The late H/M ratio decreased with age (0.082/year, p<0.001), but progression of cardiac denervation was so slow that annual repetition of MIBG imaging did not increase its prognostic accuracy. During follow-up, 70 symptomatic patients underwent liver transplantation. The late H/M ratio decreased by 0.19/year until transplantation but no statistically significant differences were detected after the procedure., Conclusions: Cardiac denervation is common during the progression of TTR-V30M FAP and quantification of the late H/M ratio on MIBG scintigraphy is valuable for prognostic stratification of these patients. Liver transplantation stabilizes cardiac denervation, without recovery or further deterioration in cardiac MIBG uptake after the procedure., (Copyright © 2017 Sociedade Portuguesa de Cardiologia. Publicado por Elsevier España, S.L.U. All rights reserved.)
- Published
- 2017
- Full Text
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44. Estimation of the collective ionizing dose in the Portuguese population for the years 2011 and 2012, due to nuclear medicine exams.
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Costa F, Teles P, Nogueira A, Barreto A, Santos AI, Carvalho A, Martins B, Oliveira C, Gaspar C, Barros C, Neves D, Costa D, Rodrigues E, Godinho F, Alves F, Cardoso G, Cantinho G, Conde I, Vale J, Santos J, Isidoro J, Pereira J, Salgado L, Rézio M, Vieira M, Simãozinho P, Almeida P, Castro R, Parafita R, Pintão S, Lúcio T, Reis T, and Vaz P
- Subjects
- Adult, Bone and Bones diagnostic imaging, Child, Dose-Response Relationship, Radiation, Health Care Surveys, Humans, Myocardial Perfusion Imaging adverse effects, Myocardial Perfusion Imaging statistics & numerical data, Nuclear Medicine Department, Hospital statistics & numerical data, Portugal, Positron-Emission Tomography adverse effects, Positron-Emission Tomography statistics & numerical data, Radiopharmaceuticals adverse effects, Surveys and Questionnaires, Radiation Dosage, Radiation Exposure, Radiation, Ionizing, Radionuclide Imaging adverse effects, Radionuclide Imaging statistics & numerical data
- Abstract
Objectives: In 2009-2010 a Portuguese consortium was created to implement the methodologies proposed by the Dose Datamed II (DDM2) project, aiming to collect data from diagnostic X-ray and nuclear medicine (NM) procedures, in order to determine the most frequently prescribed exams and the associated ionizing radiation doses for the Portuguese population. The current study is the continuation of this work, although it focuses only on NM exams for the years 2011 and 2012., Material and Methods: The annual frequency of each of the 28 selected NM exams and the average administered activity per procedure was obtained by means of a nationwide survey sent to the 35 NM centres in Portugal., Results: The results show a reduction of the number of cardiac exams performed in the last two years compared with 2010, leading to a reduction of the annual average effective dose of Portuguese population due to NM exams from 0.08 mSv ± 0.017 mSv/caput to 0.059 ± 0.011 mSv/caput in 2011 and 0.054 ± 0.011 mSv/caput in 2012. Portuguese total annual average collective effective dose due to medical procedures was estimated to be 625.6 ± 110.9 manSv in 2011 and 565.1 ± 117.3 manSv in 2012, a reduction in comparison with 2010 (840.3 ± 183.8 manSv)., Conclusions: The most frequent exams and the ones that contributed the most for total population dose were the cardiac and bone exams, although a decrease observed in 2011 and in 2012 was verified. The authors intend to perform this study periodically to identify trends in the annual Portuguese average effective dose and to help to raise awareness about the potential dose optimization., (Copyright © 2014 Elsevier España, S.L.U. and SEMNIM. All rights reserved.)
- Published
- 2015
- Full Text
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45. Reduced myocardial 123-iodine metaiodobenzylguanidine uptake: a prognostic marker in familial amyloid polyneuropathy.
- Author
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Coutinho MC, Cortez-Dias N, Cantinho G, Conceição I, Oliveira A, Bordalo e Sá A, Gonçalves S, Almeida AG, de Carvalho M, and Diogo AN
- Subjects
- Adult, Aged, Aged, 80 and over, Amyloid Neuropathies, Familial genetics, Amyloid Neuropathies, Familial mortality, Amyloid Neuropathies, Familial therapy, Cardiomyopathies genetics, Cardiomyopathies mortality, Cardiomyopathies therapy, Echocardiography, Electrocardiography, Ambulatory, Female, Genetic Predisposition to Disease, Humans, Kaplan-Meier Estimate, Liver Transplantation, Longitudinal Studies, Male, Middle Aged, Multivariate Analysis, Mutation, Phenotype, Prealbumin genetics, Predictive Value of Tests, Prognosis, Proportional Hazards Models, Prospective Studies, Radionuclide Imaging, Reproducibility of Results, Risk Factors, Time Factors, Young Adult, 3-Iodobenzylguanidine, Amyloid Neuropathies, Familial diagnostic imaging, Cardiomyopathies diagnostic imaging, Heart innervation, Radiopharmaceuticals, Sympathetic Nervous System diagnostic imaging
- Abstract
Background: Transthyretin familial amyloid polyneuropathy is a hereditary form of amyloidosis characterized by sensorimotor and autonomic neuropathy, cardiac conduction defects, and infiltrative cardiomyopathy. Previous studies have suggested that myocardial sympathetic denervation assessed by 123-iodine metaiodobenzylguanidine (MIBG) imaging occurs early in disease progression. However, its prognostic significance was never evaluated. We aimed to study the long-term prognostic value of myocardial sympathetic denervation detected by MIBG imaging in transthyretin familial amyloid polyneuropathy., Methods and Results: A total of 143 individuals with V30M transthyretin mutation underwent Holter, ambulatory blood pressure monitoring, echocardiography, and MIBG imaging. Time to all-cause death was compared with late heart-to-mediastinum MIBG uptake ratio (H/M; either in relation to the estimated lower limit of normal [1.60] or as a continuous variable) using Cox proportional hazards regression. Multivariable analyses were performed to test the prognostic accuracy of clinical, neurological, and cardiovascular parameters. During a median follow-up of 5.5 years, 32 (22%) patients died. Five-year mortality rate was 42% for late H/M <1.60 and 7% for late H/M ≥1.60 (hazard ratio, 7.19; P<0.001). Late H/M was identified as an independent prognostic predictor. Fifty-three patients were submitted to liver transplantation. In comparison with neurophysiological score-matched controls, transplanted patients had lower long-term mortality (hazard ratio, 0.32; P=0.012). Patients with late H/M<1.60 were at higher risk of unfavorable outcome but seemed to have benefited from liver transplantation., Conclusions: Cardiac sympathetic denervation as assessed by MIBG imaging is a useful prognostic marker in transthyretin familial amyloid polyneuropathy.
- Published
- 2013
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46. [Reflex sympathetic dystrophy].
- Author
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Oliveira M, Manuela M, and Cantinho G
- Subjects
- Adolescent, Female, Humans, Reflex Sympathetic Dystrophy diagnosis, Reflex Sympathetic Dystrophy therapy
- Abstract
Reflex Sympathetic Dystrophy is rare in pediatrics. It is a complex regional pain syndrome, of unknown etiology, usually post-traumatic, characterized by dysfunctions of the musculoskeletal, vascular and skin systems: severe persistent pain of a limb, sensory and vascular alterations, associated disability and psychosocial dysfunction. The diagnosis is based in high clinical suspection. In children and adolescents there are aspects that are different from the adult ones. Excessive tests may result in worsening of the clinical symptoms. Bone scintigraphy can help. Pain treatment is difficult, not specific. Physical therapies and relaxation technics give some relief. Depression must be treated. This syndrome includes fibromyalgia and complex regional pain syndrome type I. We present a clinical report of an adolescent girl, referred for pain, cold temperature, pallor and functional disability of an inferior limb, all signals disclosed by a minor trauma. She had been diagnosed depression the year before. The bone scintigraphy was a decisive test. The treatment with gabapentin, C vitamin, physiotherapy and pshycotherapy has been effective.
- Published
- 2011
47. [Cost-effectiveness of samarium-153-EDTMP for the treatment of pain due to multiple bone metastases in hormone-refractory prostate cancer versus conventional pain therapy, in Portugal].
- Author
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Macedo A, Araújo A, Melo FC, Nunes G, Cantinho G, and Amorin I
- Subjects
- Antineoplastic Agents, Hormonal therapeutic use, Cost-Benefit Analysis, Humans, Male, Portugal, Prostatic Neoplasms drug therapy, Prostatic Neoplasms pathology, Treatment Failure, Analgesics, Non-Narcotic economics, Analgesics, Non-Narcotic therapeutic use, Bone Neoplasms complications, Bone Neoplasms secondary, Organometallic Compounds economics, Organometallic Compounds therapeutic use, Organophosphorus Compounds economics, Organophosphorus Compounds therapeutic use, Pain drug therapy, Pain etiology
- Abstract
Introduction: Prostate cancer is a significant cause of morbidity and mortality. In Portugal alone, according to a study published in 2003, the rate of new prostate cancer cases were 53 per 100,000 men (in 2000), with an age-standardized mortality rate of about 28 per 100,000 (in 1995). Multiple bone metastases are one of the major complications of advanced prostate cancer. Samarium-EDTMP showed to be a safe and effective alternative for palliative treatment of bone metastases. The goal of this economic study is to assess the cost-effectiveness of Samarium-153-EDTMP for the treatment of pain due to multiple bone metastases in hormone-refractory prostate cancer versus conventional pain therapy, in Portugal., Methodology: Cost-effectiveness study that compares the expected direct costs to the National Health System of managing patients with painful multiple bone metastases with Samarium-153-EDTMP versus conventional pain therapy, in Portugal, in a 4-moths period., Results: The total direct 4 months cost was 2,311.91 euro for a patient treated with Samarium-153-EDTMP versus 2,450.74 euro for a patient under standard treatment. According to the model a patient treated with Samarium-153-EDTMP represents a 138.83 euros saving., Conclusion: Samarium-153-EDTMP was not only a very effective therapeutic option but also an option with less cost than the conventional pain therapy, in patients with pain due to multiple bone metastases, in Portugal.
- Published
- 2006
48. A new bis(3-hydroxy-4-pyridinone)-IDA derivative as a potential therapeutic chelating agent. Synthesis, metal-complexation and biological assays.
- Author
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Amélia Santos M, Gama S, Gano L, Cantinho G, and Farkas E
- Subjects
- Animals, Citrates pharmacokinetics, Gallium pharmacokinetics, Gallium Radioisotopes pharmacokinetics, Magnetic Resonance Spectroscopy, Male, Mice, Mice, Inbred Strains, Molecular Structure, Spectrophotometry, Tissue Distribution, Chelating Agents chemical synthesis, Chelating Agents chemistry, Chelating Agents therapeutic use
- Abstract
A new bis(3-hydroxy-4-pyridinone) derivative of iminodiacetic acid, imino-bis(acetyl(1-(3'-aminopropyl)-3-hydroxy-2-methyl-4-pyridinone)), IDAPr(3,4-HP)(2), has been prepared and studied in its interaction with a set of hard metal ions. This tetradentate ligand presents a much higher chelating efficiency for trivalent hard metal ions (Fe, Ga, Al) than the monodentate derivative Deferriprone, namely at the diluted conditions prevailing in physiological conditions and at low clinical doses. A similar behaviour was also observed for the complexation with Zn(II) but at a significantly lower extent. This compound presents a moderate hydrophilic character at physiological pH (logD=-1.72). In vivo assays showed much more rapid clearance of (67)Ga from most tissues of metal-loaded mice than the drug Deferriprone and the radioactivity excretion occurs mostly through the kidneys. Therefore, results from in vitro and in vivo studies indicated good perspectives for this compound to be a potential decorporating agent for hard metal ions in overload situations without depletion of essential metal ions such as zinc.
- Published
- 2004
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49. Early detection of sympathetic myocardial denervation in patients with familial amyloid polyneuropathy type I.
- Author
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Coutinho CA, Conceição I, Almeida A, Cantinho G, Sargento L, and Vagueiro MC
- Subjects
- Adult, Aged, Female, Humans, Male, Middle Aged, Time Factors, Amyloid Neuropathies, Familial complications, Heart innervation, Nervous System Diseases etiology, Sympathetic Nervous System
- Abstract
Introduction: Type I familial amyloid polyneuropathy (FAP I) is an autosomal dominant inherited disorder due to a genetic defect in transthyretin and is characterized by deposition of amyloid in various organs and tissues. The principal manifestations are related to polyneuropathy and dysautonomia. The aim of this study was to assess cardiac involvement and to correlate the findings with neurological status., Methods: 34 patients with FAP (15 male and 19 female; mean age 43 +/- 15 years) underwent I123-labeled metaiodobenzylguanidine (MIBG) myocardial scintigraphy in order to evaluate cardiac sympathetic innervation. In addition they underwent ambulatory blood pressure monitoring (ABPM) and two-dimensional and Doppler echocardiography. Neurological involvement was quantified according to a neurophysiologic score (EMG; 0 = no abnormality and 100% = maximal disability)., Results: The mean value of cardiac MIBG uptake was 1.75 +/- 0.5 (normal = 2.6 +/- 0.3) and correlated inversely with the EMG score (r = -0.67; p = 0.001). In 27 (79%) of the 34 patients there was a decrease in MIBG accumulation, in 18 (53%) an alteration in the circadian BP pattern and/or an increase in systolic and/or diastolic BP loads at night, and in 17 (50%) left ventricular hypertrophy and/or diastolic dysfunction. Twenty-two patients were symptomatic and had a mean EMG score of 37.7 +/- 25% (group I). The remaining 12 were asymptomatic and without neurological involvement (group II). Group I was characterized by older age (48 +/- 15 vs. 33 +/- 10.2 years, p = 0.01), lower MIBG uptake (1.5 +/- 0.4 vs. 2.2 +/- 0.5, p = 0.001), higher systolic (129 +/- 16 vs. 119 +/- 6 mmHg, p = 0.01) and diastolic daytime BP (82 +/- 10 vs. 76 +/- 6 mmHg, p = 0.05), and higher systolic (119 +/- 17 vs. 105 +/- 7 mmHg, p = 0.01) and diastolic nocturnal BP (71 +/- 11 vs. 62 +/- 9 mmHg, p = 0.01) than patients in group II. In 21/22 patients in group I and in 6/12 in group II there was a decrease in cardiac MIBG activity. Sixteen patients in group I and 2 in group II had abnormal circadian BP pattern. Left ventricular hypertrophy was only seen in group I., Conclusions: Patients with FAP have a high incidence of cardiac denervation and an abnormal circadian BP pattern. These alterations in cardiac autonomic function precede the development of clinical manifestations and may be an important factor in determining the optimal timing for liver transplantation, which is currently the only way to control the progression of the disease.
- Published
- 2004
50. Pulmonary scintigraphy in chronic obstructive pulmonary disease.
- Author
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Cantinho G
- Subjects
- Asthma diagnostic imaging, Child, Cystic Fibrosis diagnostic imaging, Humans, Lung diagnostic imaging, Radionuclide Imaging, Xenon Radioisotopes, Pulmonary Disease, Chronic Obstructive diagnostic imaging
- Published
- 2004
- Full Text
- View/download PDF
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