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Your search keyword '"G. A. P. Cirrone"' showing total 33 results
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33 results on '"G. A. P. Cirrone"'

1. Radioisotope production using lasers: From basic science to applications

Author

M. R. D. Rodrigues, A. Bonasera, M. Scisciò, J. A. Pérez-Hernández, M. Ehret, F. Filippi, P. L. Andreoli, M. Huault, H. Larreur, D. Singappuli, D. Molloy, D. Raffestin, M. Alonzo, G. G. Rapisarda, D. Lattuada, G. L. Guardo, C. Verona, Fe. Consoli, G. Petringa, A. McNamee, M. La Cognata, S. Palmerini, T. Carriere, M. Cipriani, G. Di Giorgio, G. Cristofari, R. De Angelis, G. A. P. Cirrone, D. Margarone, L. Giuffrida, D. Batani, P. Nicolai, K. Batani, R. Lera, L. Volpe, D. Giulietti, S. Agarwal, M. Krupka, S. Singh, and Fa. Consoli

Subjects
Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract

The discovery of chirped pulse amplification has led to great improvements in laser technology, enabling energetic laser beams to be compressed to pulse durations of tens of femtoseconds and focused to a few micrometers. Protons with energies of tens of MeV can be accelerated using, for instance, target normal sheath acceleration and focused on secondary targets. Under such conditions, nuclear reactions can occur, with the production of radioisotopes suitable for medical application. The use of high-repetition lasers to produce such isotopes is competitive with conventional methods mostly based on accelerators. In this paper, we study the production of 67Cu, 63Zn, 18F, and 11C, which are currently used in positron emission tomography and other applications. At the same time, we study the reactions 10B(p,α)7Be and 70Zn(p,4n)67Ga to put further constraints on the proton distributions at different angles, as well as the reaction 11B(p,α)8Be relevant for energy production. The experiment was performed at the 1 PW laser facility at Vega III in Salamanca, Spain. Angular distributions of radioisotopes in the forward (with respect to the laser direction) and backward directions were measured using a high purity germanium detector. Our results are in reasonable agreement with numerical estimates obtained following the approach of Kimura and Bonasera [Nucl. Instrum. Methods Phys. Res., Sect. A 637, 164–170 (2011)].

Published
2024
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2. Prompt gamma ray diagnostics and enhanced hadron-therapy using neutron-free nuclear reactions

Author

L. Giuffrida, D. Margarone, G. A. P. Cirrone, A. Picciotto, G. Cuttone, and G. Korn

Subjects
Physics, QC1-999
Abstract

We propose a series of simulations about the potential use of Boron isotopes to trigger neutron-free (aneutronic) nuclear reactions in cancer cells through the interaction with an incoming energetic proton beam, thus resulting in the emission of characteristic prompt gamma radiation (429 keV, 718 keV and 1435 keV). Furthermore assuming that the Boron isotopes are absorbed in cancer cells, the three alpha-particles produced in each p-11B aneutronic nuclear fusion reactions can potentially result in the enhancement of the biological dose absorbed in the tumor region since these multi-MeV alpha-particles are stopped inside the single cancer cell, thus allowing to spare the surrounding tissues. Although a similar approach based on the use of 11B nuclei has been proposed in [Yoon et al. Applied Physics Letters 105, 223507 (2014)], our work demonstrate, using Monte Carlo simulations, the crucial importance of the use of 10B nuclei (in a solution containing also 11B) for the generation of prompt gamma-rays, which can be applied to medical imaging. In fact, we demonstrate that the use of 10B nuclei can enhance the intensity of the 718 keV gamma-ray peak more than 30 times compared to the solution containing only 11B nuclei. A detailed explanation of the origin of the different prompt gamma-rays, as well as of their application as real-time diagnostics during a potential cancer treatment, is here discussed.

Published
2016
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3. Manipulation of laser-accelerated proton beam profiles by nanostructured and microstructured targets

Author

L. Giuffrida, K. Svensson, J. Psikal, M. Dalui, H. Ekerfelt, I. Gallardo Gonzalez, O. Lundh, A. Persson, P. Lutoslawski, V. Scuderi, J. Kaufman, T. Wiste, T. Lastovicka, A. Picciotto, A. Bagolini, M. Crivellari, P. Bellutti, G. Milluzzo, G. A. P. Cirrone, J. Magnusson, A. Gonoskov, G. Korn, C-G. Wahlström, and D. Margarone

Subjects
Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract

Nanostructured and microstructured thin foils have been fabricated and used experimentally as targets to manipulate the spatial profile of proton bunches accelerated through the interaction with high intensity laser pulses (6×10^{19} W/cm^{2}). Monolayers of polystyrene nanospheres were placed on the rear surfaces of thin plastic targets to improve the spatial homogeneity of the accelerated proton beams. Moreover, thin targets with grating structures of various configurations on their rear sides were used to modify the proton beam divergence. Experimental results are presented, discussed, and supported by 3D particle-in-cell numerical simulations.

Published
2017
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4. Spectral and spatial shaping of a laser-produced ion beam for radiation-biology experiments

Author

L. Pommarel, B. Vauzour, F. Mégnin-Chanet, E. Bayart, O. Delmas, F. Goudjil, C. Nauraye, V. Letellier, F. Pouzoulet, F. Schillaci, F. Romano, V. Scuderi, G. A. P. Cirrone, E. Deutsch, A. Flacco, and V. Malka

Subjects
Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract

The study of radiation biology on laser-based accelerators is most interesting due to the unique irradiation conditions they can produce, in terms of peak current and duration of the irradiation. In this paper we present the implementation of a beam transport system to transport and shape the proton beam generated by laser-target interaction for in vitro irradiation of biological samples. A set of four permanent magnet quadrupoles is used to transport and focus the beam, efficiently shaping the spectrum and providing a large and relatively uniform irradiation surface. Real time, absolutely calibrated, dosimetry is installed on the beam line, to enable shot-to-shot control of dose deposition in the irradiated volume. Preliminary results of cell sample irradiation are presented to validate the robustness of the full system.

Published
2017
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5. Development of a Real-Time, Large Area, High Spatial Resolution Particle Tracker Based on Scintillating Fibers

Author

D. Lo Presti, D. L. Bonanno, F. Longhitano, C. Pugliatti, S. Aiello, G. A. P. Cirrone, V. Giordano, E. Leonora, N. Randazzo, S. Reito, F. Romano, G. V. Russo, M. Russo, V. Sipala, C. Stancampiano, and C. Ventura

Subjects
Physics, QC1-999
Abstract

The design of a detector for tracking charged particles is presented together with the characterization techniques developed to extract the main design specifications. The goals for the final detector are to achieve real-time imaging performances, a large detection area, and a high spatial resolution, particularly suitable for medical imaging applications. This paper describes the prototype of the tracker plane, which has a 20 × 20 cm2 sensitive area consisting of two crossed ribbons of 500 μm square scintillating fibers. The information about the hit position extracted real-time tracker in an innovative way, using a reduced number of the read-out channels to obtain a very large detection area but with moderate costs and complexity. The performances of the tracker have been investigated using β sources, cosmic rays, and a 62 MeV proton beam.

Published
2014
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6. Proton Acceleration Driven by a Nanosecond Laser from a Cryogenic Thin Solid-Hydrogen Ribbon

Author

D. Margarone, A. Velyhan, J. Dostal, J. Ullschmied, J. P. Perin, D. Chatain, S. Garcia, P. Bonnay, T. Pisarczyk, R. Dudzak, M. Rosinski, J. Krasa, L. Giuffrida, J. Prokupek, V. Scuderi, J. Psikal, M. Kucharik, M. De Marco, J. Cikhardt, E. Krousky, Z. Kalinowska, T. Chodukowski, G. A. P. Cirrone, and G. Korn

Subjects
Physics, QC1-999
Abstract

A high-power pulsed laser is focused onto a solid-hydrogen target to accelerate forward a collimated stream of protons in the range 0.1–1 MeV, carrying a very high energy of about 30 J (∼5% laser-ion conversion efficiency) and extremely large charge of about ∼0.1 mC per laser pulse. This result is achieved for the first time through the combination of a sophisticated target system (H_{2} thin ribbon) operating at cryogenic temperature (∼10 K) and a very hot H plasma (∼300 keV “hot electron” temperature) generated by a subnanosecond laser with an intensity of ∼3×10^{16} W/cm^{2}. Both the H plasma and the accelerated proton beam are fully characterized by in situ and ex situ diagnostics. Results obtained using the ELISE (experiments on laser interaction with solid hydrogen) H_{2} target delivery system at PALS (Prague) kJ-class laser facility are presented and discussed along with potential multidisciplinary applications.

Published
2016
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7. 4He dose- and track-averaged linear energy transfer: Monte Carlo algorithms and experimental verification

Author

S Fattori, G Petringa, S Agosteo, D Bortot, V Conte, G Cuttone, A Di Fini, F Farokhi, D Mazzucconi, L Pandola, I Petrović, A Ristić-Fira, A Rosenfeld, U Weber, and G A P Cirrone

Subjects
Ions, Radiological and Ultrasound Technology, linear energy transfer, target fragmentation, Geant4, Radiology, Nuclear Medicine and imaging, Protons, Radiometry, Monte Carlo Method, Monte Carlo, Algorithms, microdosimetry
Abstract

Objective. In the present hadrontherapy scenario, there is a growing interest in exploring the capabilities of different ion species other than protons and carbons. The possibility of using different ions paves the way for new radiotherapy approaches, such as the multi-ions treatment, where radiation could vary according to target volume, shape, depth and histologic characteristics of the tumor. For these reasons, in this paper, the study and understanding of biological-relevant quantities was extended for the case of 4He ion. Approach. Geant4 Monte Carlo based algorithms for dose- and track-averaged LET (Linear Energy Transfer) calculations, were validated for 4He ions and for the case of a mixed field characterised by the presence of secondary ions from both target and projectile fragmentation. The simulated dose and track averaged LETs were compared with the corresponding dose and frequency mean values of the lineal energy, y D ¯ and y ¯ F , derived from experimental microdosimetric spectra. Two microdosimetric experimental campaigns were carried out at the Italian eye proton therapy facility of the Laboratori Nazionali del Sud of Istituto Nazionale di Fisica Nucleare (INFN-LNS, Catania, I) using two different microdosimeters: the MicroPlus probe and the nano-TEPC (Tissue Equivalent Proportional Counter). Main results. A good agreement of L ¯ d Total and L ¯ t Total with y ¯ D and y ¯ T experimentally measured with both microdosimetric detectors MicroPlus and nano-TEPC in two configurations: full energy and modulated 4He ion beam, was found. Significance. The results of this study certify the use of a very effective tool for the precise calculation of LET, given by a Monte Carlo approach which has the advantage of allowing detailed simulation and tracking of nuclear interactions, even in complex clinical scenarios.

Published
2022

8. Experimental investigation at CATANA facility of n

Author

D, Mazzucconi, D, Bortot, A, Pola, A, Fazzi, L, Cazzola, V, Conte, G A P, Cirrone, G, Petringa, G, Cuttone, L, Manti, and S, Agosteo

Subjects
Neutrons, Proton Therapy, Boron Neutron Capture Therapy, Protons, Boron
Abstract

The aim of the NEPTUNE (Nuclear process-driven Enhancement of Proton Therapy UNravEled) project is to investigate in detail both the physical and radiobiological phenomena that could justify an increase of the proton-induced cytogenetic effects in cells irradiated in presence of an agent containing natural boron. In this work, a double-stage silicon telescope coupled to different boron converters was irradiated at the CATANA proton therapy facility (INFN-LNS) for studying the proton boron fusion and the neutron boron capture reactions by discriminating secondary particles from primary protons. Different boron targets were developed by depositing boric acid, enriched with a higher than 99% content of

Published
2021

9. High-current stream of energetic α particles from laser-driven proton-boron fusion

Author

Lorenzo Giuffrida, Pierluigi Bellutti, Antonino Picciotto, Valentina Scuderi, Valeria Istokskaia, G. A. P. Cirrone, Fabio Belloni, Josef Krasa, Giuliana Milluzzo, Roberto Catalano, Andriy Velyhan, Milan Kucharik, R. Dudzak, Jan Dostál, Georg Korn, Salvatore Tudisco, Marcin Rosinski, Daniele Margarone, Claudio Verona, Giada Petringa, and Karel Jungwirth

Subjects
Statistics and Probability, Nuclear reaction, Materials science, Proton, chemistry.chemical_element, 01 natural sciences, 010305 fluids & plasmas, law.invention, law, 0103 physical sciences, Nuclear fusion, Nuclear Experiment, 010306 general physics, Boron, Settore FIS/01, Fusion, Pulse duration, Statistical and Nonlinear Physics, Plasma, Condensed Matter Physics, Laser, chemistry, Atomic physics
Abstract

The nuclear reaction known as proton-boron fusion has been triggered by a subnanosecond laser system focused onto a thick boron nitride target at modest laser intensity (∼10^{16}W/cm^{2}), resulting in a record yield of generated α particles. The estimated value of α particles emitted per laser pulse is around 10^{11}, thus orders of magnitude higher than any other experimental result previously reported. The accelerated α-particle stream shows unique features in terms of kinetic energy (up to 10 MeV), pulse duration (∼10 ns), and peak current (∼2 A) at 1 m from the source, promising potential applications of such neutronless nuclear fusion reactions. We have used a beam-driven fusion scheme to explain the total number of α particles generated in the nuclear reaction. In this model, protons accelerated inside the plasma, moving forward into the bulk of the target, can interact with ^{11}B atoms, thus efficiently triggering fusion reactions. An overview of literature results obtained with different laser parameters, experimental setups, and target compositions is reported and discussed.

Published
2019
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10. STUDY OF THE DISCREPANCY BETWEEN ANALYTICAL CALCULATIONS AND THE OBSERVED BIOLOGICAL EFFECTIVENESS IN PROTON BORON CAPTURE THERAPY (PBCT)

Author

G. A. P. Cirrone, Lorenzo Manti, G. Petringa, A. Attili, D. Chiappara, Daniele Margarone, Giacomo Cuttone, Valentina Bravatà, M. Mazzocco, Cirrone, G. A. P., Petringa, G., Attili, A., Chiappara, D., Manti, L., Bravatà, V., Margarone, D., Mazzocco, M., and Cuttone, G.

Subjects
Materials science, Proton, chemistry, Media Technology, Physical chemistry, chemistry.chemical_element, Boron
Published
2019
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11. Miniaturized microdosimeters as LET monitors: First comparison of calculated and experimental data performed at the 62 MeV/u

Author

P, Colautti, V, Conte, A, Selva, S, Chiriotti, A, Pola, D, Bortot, A, Fazzi, S, Agosteo, M, Treccani, L, De Nardo, C, Verona, G Verona, Rinati, G, Magrin, G A P, Cirrone, and F, Romano

Subjects
Carbon Isotopes, Miniaturization, Phantoms, Imaging, Calibration, Polymethyl Methacrylate, Water, Computer Simulation, Heavy Ion Radiotherapy, Radiotherapy Dosage, Equipment Design, Radiometry, Monte Carlo Method
Abstract

The aim of this paper is to investigate the limits of LET monitoring of therapeutic carbon ion beams with miniaturized microdosimetric detectors.Four different miniaturized microdosimeters have been used at the 62 MeV/uIn these first measurements, no detector was found to be significantly better than the others as a LET monitor. The y-All the four microdosimeters are able to monitor the dose-mean LET with the 11% precision up to the distal edge. In the distal edge region, the ratio of y

Published
2018

12. DoPET: an in-treatment monitoring system for particle therapy

Author

Aafke Kraan, G. Battistoni, Paola Sala, Giacomo Cuttone, Emanuele Zaccaro, Niccolò Camarlinghi, M. Pullia, Fabrizio Romano, N. Belcari, Giancarlo Sportelli, F. Collini, A. Ferrari, Mario Ciocca, Valeria Rosso, G. A. P. Cirrone, S. Ferretti, Andrea Mairani, Silvia Molinelli, and A. Del Guerra

Subjects
medicine.medical_specialty, Particle therapy, Oncology, business.industry, Radiology Nuclear Medicine and imaging, medicine.medical_treatment, medicine, Radiology, Nuclear Medicine and imaging, Radiology, Hematology, business, Treatment monitoring
Published
2016
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13. Faraday Cup: absolute dosimeter for ELIMED beam line

Author

R. Leanza, F. Romano, F. Schillaci, G. A. P. Cirrone, G. Cuttone, V. Scuderi, A. Amato, A. G. Amico, M. Borghesi, G. Candiano, S. Cavallaro, D. Doria, G. Korn, G. La Rosa, D. Margarone, G. Milluzzo, G. Petringa, S. Pulvirenti, D. Rizzo, and S. Salamone

Published
2016
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18. Lethal and sub-lethal damage along and around a 62 MeV/u spread out Carbon beam

Author

G. Schettino, J. N. Kavanagh, F. Currell, G. A. P. Cirrone, F. Romano, K. M. Prise, MANTI, LORENZO, GROSSI, GIANFRANCO, G., Schettino, J. N., Kavanagh, Manti, Lorenzo, F., Currell, G. A. P., Cirrone, F., Romano, Grossi, Gianfranco, and K. M., Prise

Subjects
Late effects of hadrontherapy, Bragg peak, Carbon Ion
Published
2011

19. SuperB Progress Reports -- Detector

Author

M. Baszczyk, P. Dorosz, J. Kolodziej, W. Kucewicz, M. Sapor, A. Jeremie, E. Grauges Pous, G. E. Bruno, G. De Robertis, D. Diacono, G. Donvito, P. Fusco, F. Gargano, F. Giordano, F. Loddo, F. Loparco, G. P. Maggi, V. Manzari, M. N. Mazziotta, E. Nappi, A. Palano, B. Santeramo, I. Sgura, L. Silvestris, V. Spinoso, G. Eigen, J. Zalieckas, Z. Zhu, L. Jenkovszky, G. Balbi, M. Boldini, D. Bonacorsi, V. Cafaro, I. D'Antone, G. M. Dallavalle, R. Di Sipio, F. Fabbri, L. Fabbri, A. Gabrielli, D. Galli, P. Giacomelli, V. Giordano, F. M. Giorgi, C. Grandi, I. Lax, S. Lo Meo, U. Marconi, A. Montanari, G. Pellegrini, M. Piccinini, T. Rovelli, N. Semprini Cesari, G. Torromeo, N. Tosi, R. Travaglini, V. M. Vagnoni, S. Valentinetti, M. Villa, A. Zoccoli, J. F. Caron, C. Hearty, P. F. T. Lu, T. S. Mattison, J. A. McKenna, R. Y. C. So, M. Y.u. Barnyakov, V. E. Blinov, A. A. Botov, V. P. Druzhinin, V. B. Golubev, S. A. Kononov, E. A. Kravchenko, E. B. Levichev, A. P. Onuchin, S. I. Serednyakov, D. A. Shtol, Y. I. Skovpen, E. P. Solodov, A. Cardini, M. Carpinelli, D. S. T. Chao, C. H. Cheng, D. A. Doll, B. Echenard, K. Flood, J. Hanson, D. G. Hitlin, P. Ongmongkolkul, F. C. Porter, R. Y. Zhu, N. Randazzo, E. De La Cruz Burelo, Y. Zheng, P. Campos, M. De Silva, A. Kathirgamaraju, B. Meadows, B. Pushpawela, Y. Shi, M. Sokoloff, G. Lopez Castro, V. Ciaschini, P. Franchini, F. Giacomini, A. Paolini, G. A. Calderon Polania, S. Laczek, P. Romanowicz, B. Szybinski, M. Czuchry, L. Flis, D. Harezlak, J. Kocot, M. Radecki, M. Sterzel, T. Szepieniec, T. Szymocha, P. Wójcik, M. Andreotti, W. Baldini, R. Calabrese, V. Carassiti, G. Cibinetto, A. Cotta Ramusino, F. Evangelisti, A. Gianoli, E. Luppi, R. Malaguti, M. Manzali, M. Melchiorri, M. Munerato, C. Padoan, V. Santoro, L. Tomassetti, M. M. Beretta, M. Biagini, M. Boscolo, E. Capitolo, R. de Sangro, M. Esposito, G. Felici, G. Finocchiaro, M. Gatta, C. Gatti, S. Guiducci, S. Lauciani, P. Patteri, I. Peruzzi, M. Piccolo, P. Raimondi, M. Rama, C. Sanelli, S. Tomassini, P. Fabbricatore, D. Delepine, M. A. Reyes Santos, M. Chrzaszcz, R. Grzymkowski, P. Knap, J. Kotula, T. Lesiak, J. Ludwin, J. Michalowski, B. Pawlik, B. Rachwal, M. Stodulski, J. Wiechczynski, M. Witek, L. Zawiejski, M. Zdybal, V. Y. Aushev, A. Ustynov, N. Arnaud, P. Bambade, C. Beigbeder, F. Bogard, M. Borsato, D. Breton, J. Brossard, L. Burmistrov, D. Charlet, V. Chaumat, O. Dadoun, M. El Berni, J. Maalmi, V. Puill, C. Rimbault, A. Stocchi, V. Tocut, A. Variola, S. Wallon, G. Wormser, F. Grancagnolo, E. Ben Haim, S. Sitt, M. Baylac, O. Bourrion, J. M. Deconto, Y. Gomez Martinez, N. Monseu, J. F. Muraz, J. S. Real, C. Vescovi, R. Cenci, A. Jawahery, D. Roberts, E. W. Twedt, R. Cheaib, D. Lindemann, S. Nderitu, P. Patel, S. H. Robertson, D. Swersky, A. Warburton, E. Cuautle Flores, G. Toledo Sanchez, P. Biassoni, L. Bombelli, M. Citterio, S. Coelli, C. Fiorini, V. Liberali, M. Monti, B. Nasri, N. Neri, F. Palombo, F. Sabatini, A. Stabile, A. Berra, A. Giachero, C. Gotti, D. Lietti, M. Maino, G. Pessina, M. Prest, J. P. Martin, M. Simard, N. Starinski, P. Taras, A. Drutskoy, S. Makarychev, A. V. Nefediev, A. Aloisio, G. De Nard, DELLA PIETRA, MASSIMO, A. Doria, GIORDANO, RAFFAELE, A. Ordine, S. Pardi, RUSSO, GUIDO, C. Sciacca, I. I. Bigi, C. P. Jessop, W. Wang, M. Bellato, M. Benettoni, M. Corvo, A. Crescente, F. Dal Corso, U. Dosselli, C. Fanin, A. Gianelle, S. Longo, M. Michelotto, F. Montecassiano, M. Morandin, R. Pengo, M. Posocco, M. Rotondo, G. Simi, R. Stroili, L. Gaioni, A. Manazza, M. Manghisoni, L. Ratti, V. Re, G. Traversi, S. Zucca, S. Bizzaglia, M. Bizzarri, C. Cecchi, S. Germani, M. Lebeau, P. Lubrano, E. Manoni, A. Papi, A. Rossi, G. Scolieri, G. Batignani, S. Bettarini, G. Casarosa, A. Cervelli, A. Fella, F. Forti, M. Giorgi, L. Lilli, A. Lusiani, B. Oberhof, A. Paladino, F. Pantaleo, E. Paoloni, A. L. Perez Perez, G. Rizzo, J. Walsh, A. Fernández Téllez, G. Beck, M. Berman, A. Bevan, F. Gannaway, G. Inguglia, A. J. Martin, J. Morris, V. Bocci, M. Capodiferro, G. Chiodi, I. Dafinei, N. V. Drenska, R. Faccini, F. Ferroni, C. Gargiulo, P. Gauzzi, C. Luci, R. Lunadei, G. Martellotti, F. Pellegrino, V. Pettinacci, D. Pinci, L. Recchia, D. Ruggeri, A. Zullo, P. Camarri, R. Cardarelli, C. De Santis, A. Di Ciaccio, V. Di Felice, F. Di Palma, A. Di Simone, L. Marcelli, R. Messi, D. Moricciani, R. Sparvoli, S. Tammaro, P. Branchini, A. Budano, S. Bussino, M. Ciuchini, F. Nguyen, A. Passeri, F. Ruggieri, E. Spiriti, F. Wilson, I. Leon Monzon, J. R. Millan Almaraz, P. L. M. Podesta Lerma, D. Aston, B. Dey, A. Fisher, P. D. Jackson, D. W. G. S. Leith, S. Luitz, D. MacFarlane, M. McCulloch, S. Metcalfe, A. Novokhatski, S. Osier, R. Prepost, B. Ratcliff, J. Seeman, M. Sullivan, J. Va'vra, U. Wienands, W. Wisniewski, B. D. Altschul, M. V. Purohit, J. Baudot, I. Ripp Baudot, G. A. P. Cirrone, G. Cuttone, O. Bezshyyko, G. Dolinska, A. Soffer, F. Bianchi, F. De Mori, A. Filippi, D. Gamba, S. Marcello, M. Bomben, L. Bosisio, P. Cristaudo, L. Lanceri, B. Liberti, I. Rashevskaya, C. Stella, E. S. Vallazza, L. Vitale, G. Auriemma, C. Satriano, F. Martinez Vidal, J. Mazorra de Cos, A. Oyanguren, P. Ruiz Valls, A. Beaulieu, S. Dejong, J. Franta, M. J. Lewczuk, M. Roney, R. Sobie, CAVALIERE, SERGIO, M. Baszczyk , P. Dorosz, J. Kolodziej, W. Kucewicz, M. Sapor, A. Jeremie, E. Grauges Pous, G.E. Bruno, G. De Robertis, D. Diacono, G. Donvito, P. Fusco, F. Gargano, F. Giordano, F. Loddo, F. Loparco, G.P. Maggi, V. Manzari, M.N. Mazziotta, E. Nappi, A. Palano, B. Santeramo, I. Sgura, L. Silvestris, V. Spinoso, G. Eigen, J. Zalieckas, Z. Zhu, L. Jenkovszky, G. Balbi, M. Boldini, D. Bonacorsi, V. Cafaro, I. D'Antone, G.M. Dallavalle , R. Di Sipio, F. Fabbri, L. Fabbri, A. Gabrielli, D. Galli , P. Giacomelli, V. Giordano, F.M. Giorgi, C. Grandi, I. Lax , S. Lo Meo , U. Marconi, A. Montanari, G. Pellegrini , M. Piccinini, T. Rovelli, N. Semprini Cesari , G. Torromeo , N. Tosi , R. Travaglini, V.M. Vagnoni , S. Valentinetti, M. Villa, A. Zoccoli , J. -F. Caron , C. Hearty, P. F. -T. Lu, T.S. Mattison, J.A. McKenna, R. Y. -C. So , M. Yu. Barnyakov, V.E. Blinov, A.A. Botov, V.P. Druzhinin, V.B. Golubev, S.A. Kononov, E.A. Kravchenko, E.B. Levichev, A.P. Onuchin, S.I. Serednyakov, D.A. Shtol, M., Baszczyk, P., Dorosz, J., Kolodziej, W., Kucewicz, M., Sapor, A., Jeremie, E., Grauges Pou, G. E., Bruno, G., De Roberti, D., Diacono, G., Donvito, P., Fusco, F., Gargano, F., Giordano, F., Loddo, F., Loparco, G. P., Maggi, V., Manzari, M. N., Mazziotta, E., Nappi, A., Palano, B., Santeramo, I., Sgura, L., Silvestri, V., Spinoso, G., Eigen, J., Zaliecka, Z., Zhu, L., Jenkovszky, G., Balbi, M., Boldini, D., Bonacorsi, V., Cafaro, I., D'Antone, G. M., Dallavalle, R., Di Sipio, F., Fabbri, L., Fabbri, A., Gabrielli, D., Galli, P., Giacomelli, V., Giordano, F. M., Giorgi, C., Grandi, I., Lax, S., Lo Meo, U., Marconi, A., Montanari, G., Pellegrini, M., Piccinini, T., Rovelli, N., Semprini Cesari, G., Torromeo, N., Tosi, R., Travaglini, V. M., Vagnoni, S., Valentinetti, M., Villa, A., Zoccoli, J. F., Caron, C., Hearty, P. F. T., Lu, T. S., Mattison, J. A., Mckenna, R. Y. C., So, Barnyakov, M. Y. u., V. E., Blinov, A. A., Botov, V. P., Druzhinin, V. B., Golubev, S. A., Kononov, E. A., Kravchenko, E. B., Levichev, A. P., Onuchin, S. I., Serednyakov, D. A., Shtol, Y. I., Skovpen, E. P., Solodov, A., Cardini, M., Carpinelli, D. S. T., Chao, C. H., Cheng, D. A., Doll, B., Echenard, K., Flood, J., Hanson, D. G., Hitlin, P., Ongmongkolkul, F. C., Porter, R. Y., Zhu, N., Randazzo, E., De La Cruz Burelo, Y., Zheng, P., Campo, M., De Silva, A., Kathirgamaraju, B., Meadow, B., Pushpawela, Y., Shi, M., Sokoloff, G., Lopez Castro, V., Ciaschini, P., Franchini, F., Giacomini, A., Paolini, G. A., Calderon Polania, S., Laczek, P., Romanowicz, B., Szybinski, M., Czuchry, L., Fli, D., Harezlak, J., Kocot, M., Radecki, M., Sterzel, T., Szepieniec, T., Szymocha, P., Wójcik, M., Andreotti, W., Baldini, R., Calabrese, V., Carassiti, G., Cibinetto, A., Cotta Ramusino, F., Evangelisti, A., Gianoli, E., Luppi, R., Malaguti, M., Manzali, M., Melchiorri, M., Munerato, C., Padoan, V., Santoro, L., Tomassetti, M. M., Beretta, M., Biagini, M., Boscolo, E., Capitolo, R., de Sangro, M., Esposito, G., Felici, G., Finocchiaro, M., Gatta, C., Gatti, S., Guiducci, S., Lauciani, P., Patteri, I., Peruzzi, M., Piccolo, P., Raimondi, M., Rama, C., Sanelli, S., Tomassini, P., Fabbricatore, D., Delepine, M. A., Reyes Santo, M., Chrzaszcz, R., Grzymkowski, P., Knap, J., Kotula, T., Lesiak, J., Ludwin, J., Michalowski, B., Pawlik, B., Rachwal, M., Stodulski, J., Wiechczynski, M., Witek, L., Zawiejski, M., Zdybal, V. Y., Aushev, A., Ustynov, N., Arnaud, P., Bambade, C., Beigbeder, F., Bogard, M., Borsato, D., Breton, J., Brossard, L., Burmistrov, D., Charlet, V., Chaumat, O., Dadoun, M., El Berni, J., Maalmi, V., Puill, C., Rimbault, A., Stocchi, V., Tocut, A., Variola, S., Wallon, G., Wormser, F., Grancagnolo, E., Ben Haim, S., Sitt, M., Baylac, O., Bourrion, J. M., Deconto, Y., Gomez Martinez, N., Monseu, J. F., Muraz, J. S., Real, C., Vescovi, R., Cenci, A., Jawahery, D., Robert, E. W., Twedt, R., Cheaib, D., Lindemann, S., Nderitu, P., Patel, S. H., Robertson, D., Swersky, A., Warburton, E., Cuautle Flore, G., Toledo Sanchez, P., Biassoni, L., Bombelli, M., Citterio, S., Coelli, C., Fiorini, V., Liberali, M., Monti, B., Nasri, N., Neri, F., Palombo, F., Sabatini, A., Stabile, A., Berra, A., Giachero, C., Gotti, D., Lietti, M., Maino, G., Pessina, M., Prest, J. P., Martin, M., Simard, N., Starinski, P., Tara, A., Drutskoy, S., Makarychev, A. V., Nefediev, A., Aloisio, Cavaliere, Sergio, G., De Nard, DELLA PIETRA, Massimo, A., Doria, Giordano, Raffaele, A., Ordine, S., Pardi, Russo, Guido, C., Sciacca, I. I., Bigi, C. P., Jessop, W., Wang, M., Bellato, M., Benettoni, M., Corvo, A., Crescente, F., Dal Corso, U., Dosselli, C., Fanin, A., Gianelle, S., Longo, M., Michelotto, F., Montecassiano, M., Morandin, R., Pengo, M., Posocco, M., Rotondo, G., Simi, R., Stroili, L., Gaioni, A., Manazza, M., Manghisoni, L., Ratti, V., Re, G., Traversi, S., Zucca, S., Bizzaglia, M., Bizzarri, C., Cecchi, S., Germani, M., Lebeau, P., Lubrano, E., Manoni, A., Papi, A., Rossi, G., Scolieri, G., Batignani, S., Bettarini, G., Casarosa, A., Cervelli, A., Fella, F., Forti, M., Giorgi, L., Lilli, A., Lusiani, B., Oberhof, A., Paladino, F., Pantaleo, E., Paoloni, A. L., Perez Perez, G., Rizzo, J., Walsh, A., Fernández Téllez, G., Beck, M., Berman, A., Bevan, F., Gannaway, G., Inguglia, A. J., Martin, J., Morri, V., Bocci, M., Capodiferro, G., Chiodi, I., Dafinei, N. V., Drenska, R., Faccini, F., Ferroni, C., Gargiulo, P., Gauzzi, C., Luci, R., Lunadei, G., Martellotti, F., Pellegrino, V., Pettinacci, D., Pinci, L., Recchia, D., Ruggeri, A., Zullo, P., Camarri, R., Cardarelli, C., De Santi, A., Di Ciaccio, V., Di Felice, F., Di Palma, A., Di Simone, L., Marcelli, R., Messi, D., Moricciani, R., Sparvoli, S., Tammaro, P., Branchini, A., Budano, S., Bussino, M., Ciuchini, F., Nguyen, A., Passeri, F., Ruggieri, E., Spiriti, F., Wilson, I., Leon Monzon, J. R., Millan Almaraz, P. L. M., Podesta Lerma, D., Aston, B., Dey, A., Fisher, P. D., Jackson, D. W. G. S., Leith, S., Luitz, D., Macfarlane, M., Mcculloch, S., Metcalfe, A., Novokhatski, S., Osier, R., Prepost, B., Ratcliff, J., Seeman, M., Sullivan, J., Va'Vra, U., Wienand, W., Wisniewski, B. D., Altschul, M. V., Purohit, J., Baudot, I., Ripp Baudot, G. A. P., Cirrone, G., Cuttone, O., Bezshyyko, G., Dolinska, A., Soffer, F., Bianchi, F., De Mori, A., Filippi, D., Gamba, S., Marcello, M., Bomben, L., Bosisio, P., Cristaudo, L., Lanceri, B., Liberti, I., Rashevskaya, C., Stella, E. S., Vallazza, L., Vitale, G., Auriemma, C., Satriano, F., Martinez Vidal, J., Mazorra de Co, A., Oyanguren, P., Ruiz Vall, A., Beaulieu, S., Dejong, J., Franta, M. J., Lewczuk, M., Roney, R., Sobie, Universitat Autònoma de Barcelona (UAB), Laboratoire de l'Accélérateur Linéaire (LAL), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratori Nazionali di Frascati (LNF), Istituto Nazionale di Fisica Nucleare (INFN), Laboratoire de Physique Nucléaire et de Hautes Énergies (LPNHE), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), SLAC National Accelerator Laboratory (SLAC), Stanford University, SuperB, and Starita, Sabine

Subjects
[PHYS.HEXP] Physics [physics]/High Energy Physics - Experiment [hep-ex], [PHYS.PHYS.PHYS-INS-DET] Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], [PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex], [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det]
Abstract

95 pages, 48 pdf figures; This report describes the present status of the detector design for SuperB. It is one of four separate progress reports that, taken collectively, describe progress made on the SuperB Project since the publication of the SuperB Conceptual Design Report in 2007 and the Proceedings of SuperB Workshop VI in Valencia in 2008. The other three reports relate to Physics, Accelerator and Computing.

Published
2010

20. Corrigendum: Charged particles flux measurement from PMMA irradiated by 80 MeV u−1carbon ion beam (Phys. Med. Biol.57 5667)

Author

Francesco Collamati, Luca Piersanti, S. Fiore, Michela Marafini, R. Faccini, C. Agodi, E. Iarocci, E. Vitale, Alessio Sarti, F. Ferroni, Vincenzo Patera, A. Sciubba, Silvia Muraro, A. Paoloni, C. Voena, Giacomo Cuttone, G. Battistoni, G. A. P. Cirrone, P. Gauzzi, E. De Lucia, I. Mattei, M. De Napoli, F. Bellini, A. Di Domenico, and Fabrizio Romano

Subjects
Materials science, Radiological and Ultrasound Technology, Carbon ion beam, Flux, Radiology, Nuclear Medicine and imaging, Irradiation, Atomic physics, Charged particle
Published
2014
Full Text
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21. Dosimetric and clinical experience in eye proton treatment at INFN-LNS

Author

G. A. P. Cirrone, G. Cuttone, F. Di Rosa, P. Lojacono, V. Mongelli, S. Lo Nigro, J. Ott, I. V. Patti, S. Pittera, G. Privitera, L. Raffaele, A. Reibaldi, G. Russo, V. Salamone, M. G. Sabini, C. Spatola, L. M. Valastro, Sun-Chan Jeong, Yutaka Utsuno, Tohru Motobayashi, and Angela Bracco

Subjects
Physics, Radiation therapy, Patient diagnosis, High energy, Superconducting cyclotron, Proton, business.industry, medicine.medical_treatment, medicine, Nuclear medicine, business, Proton therapy
Abstract

After six years of activity 155 patients have been treated inside the CATANA (Centro di AdroTerapia ed Applicazioni Nucleari Avanzate) facility. CATANA is the first and unique proton therapy facility in which the 62 MeV proton beams, accelerated by a Superconducting Cyclotron, are used for the radio‐therapeutic treatments of choroidal and iris melanomas. Inside CATANA new absolute and relative dosimetric techniques have been developed in order to achieve the best results in terms of treatment precision and dose release accuracy. The follow‐up results for 42 patients demonstrated the efficacy of high energy protons in the radiotherapeutic field and encouraged us in our activity in the battle against cancer

Published
2009
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23. TEST RESULTS FROM AN IN-BEAM PET SYSTEM

Author

F. Attanasi, N. Belcari, M. Camarda, G. A. P. Cirrone, G. Cuttone, A. Del Guerra, F. Di Rosa, V. Rosso, G. Russo, S. Vecchio, LANCONELLI, NICO, F. Attanasi, N. Belcari, M. Camarda, G.A.P. Cirrone, G. Cuttone, A. Del Guerra, F. Di Rosa, N. Lanconelli, V. Rosso, G. Russo, and S. Vecchio

Published
2006

24. 45: The ELIMED (Multidisciplinary and Medical applications at the ELI-Beams) network perspectives for laser driven beam applications

Author

Francesco Schillaci, Mario Maggiore, Marco Borghesi, T Licciardello, C. Stancampiano, Georg Korn, D. Margarone, Fabrizio Romano, Ivan Petrović, G. A. P. Cirrone, A. Ristic Fira, Domenico Doria, A. Tramontana, Giacomo Cuttone, Lorenzo Manti, M. Carpinelli, Valentina Scuderi, and P. Pisciotta

Subjects
Materials science, Optics, Oncology, law, business.industry, Multidisciplinary approach, Radiology, Nuclear Medicine and imaging, Hematology, Laser, business, Beam (structure), law.invention
Published
2014
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27. Corrigendum: Charged particles flux measurement from PMMA irradiated by 80 MeV u−1 carbon ion beam (Phys. Med. Biol. 57 5667).

Author

C Agodi, G A P Cirrone, G Cuttone, M De Napoli, F Romano, G Battistoni, S Muraro, E Vitale, S Fiore, F Bellini, F Collamati, A Di Domenico, R Faccini, F Ferroni, P Gauzzi, I Mattei, C Voena, M Marafini, E De Lucia, and A Paoloni

Subjects
IRRADIATION, ION beams
Abstract

A correction to the article "Charged particles flux measurement from PMMA irradiated by 80 MeV u−1 carbon ion beam" that was published in the November 17, 2014 issue is presented.

Published
2014
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28. Investigations of DNA damage induction and repair resulting from cellular exposure to high dose-rate pulsed proton beams

Author

Marco Borghesi, Giuseppe Antonio Malfa, Giuseppe Schettino, Marco Favetta, G.A.P. Cirrone, Barbara Tomasello, Marcella Renis, Lorenzo Manti, Francesco Romano, Margarone, Daniele, Cirrone, Pablo, Cuttone, Giacomo, Korn, George, M., Reni, M., Borghesi, M., Favetta, G., Malfa, Manti, Lorenzo, F., Romano, G., Schettino, B., Tomasello, and G. A. P., Cirrone

Subjects
"DNA damage", Materials science, Radiobiology, Laser-driven proton beams, medicine.medical_treatment, Brachytherapy, Radiochemistry, Ion, Radiation therapy, SDG 3 - Good Health and Well-being, Orders of magnitude (radiation), Bystander effect, medicine, Dosimetry, Irradiation, Biomedical engineering
Abstract

Studies regarding the radiobiological effects of low dose radiation, microbeam irradiation services have been developed in the world and today laser acceleration of protons and heavy ions may be used in radiation therapy. The application of different facilities is essential for studying bystander effects and relating signalling phenomena in different cells or tissues. In particular the use of ion beams results advantageous in cancer radiotherapy compared to more commonly used X-rays, since the ability of ions in delivering lethal amount of doses into the target tumour avoiding or limiting damage to the contiguous healthy tissues. At the INFN-LNS in Catania, a multidisciplinary radiobiology group is strategically structured aimed to develop radiobiological research, finalised to therapeutic applications, compatible with the use of high dose laser-driven ion beams. The characteristic non-continuous dose rates with several orders of magnitude of laser-driven ion beams makes this facility very interesting in the cellular systems' response to ultra-high dose rates with non-conventional pulse time intervals cellular studies. Our group have projected to examine the effect of high dose laser-driven ion beams on two cellular types: foetal fibroblasts (normal control cells) and DU145 (prostate cancer cells), studying the modulation of some different bio-molecular parameters, in particular cell proliferation and viability, DNA damage, redox cellular status, morphological alterations of both the cytoskeleton components and some cell organelles and the possible presence of apoptotic or necrotic cell death. Our group performed preliminary experiments with high energy (60 MeV), dose rate of 10 Gy/min, doses of 1, 2, 3 Gy and LET 1 keV/mu m on human foetal fibroblasts (control cells). We observed that cell viability was not influenced by the characteristics of the beam, the irradiation conditions or the analysis time. Conversely, DNA damage was present at time 0, immediately following irradiation in a dose-dependent manner. The analysis of repair capability showed that the cells irradiated with 1 and 2 Gy almost completely recovered from the damage, but not, however, 3 Gy treated cells in which DNA damage was not recovered. In addition, the results indicate the importance of the use of an appropriate control in radiobiological in vitro analysis.

Published
2013
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29. SuperB Technical Design Report

Author

Superb, Collaboration, Baszczyk, M., Dorosz, P., Kolodziej, J., Kucewicz, W., Sapor, M., Jeremie, A., Grauges Pous, E., Bruno, G. E., De Robertis, G., Diacono, D., Donvito, G., Fusco, P., Gargano, F., Giordano, F., Loddo, F., Loparco, F., Maggi, G. P., Manzari, V., Mazziotta, M. N., Nappi, E., Palano, A., Santeramo, B., Sgura, I., Silvestris, L., Spinoso, V., Eigen, G., Zalieckas, J., Zhuo, Z., Jenkovszky, L., Balbi, G., Boldini, M., Bonacorsi, D., Cafaro, V., D'Antone, I., Dallavalle, G. M., Di Sipio, R., Fabbri, F., Fabbri, L., Gabrielli, A., Galli, D., Giacomelli, P., Giordano, V., Giorgi, F. M., Grandi, C., Lax, I., Lo Meo, S., Marconi, U., Montanari, A., Pellegrini, G., Piccinini, M., Rovelli, T., Semprini Cesari, N., Torromeo, G., Tosi, N., Travaglini, R., Vagnoni, V. M., Valentinetti, S., Villa, M., Zoccoli, A., Caron, J. F., Hearty, C., P. F. T., Lu, Mattison, T. S., Mckenna, J. A., R. Y. C., So, Yu Barnyakov, M. Y. u. Barnyakov, Blinov, V. E., Botov, A. A., Druzhinin, V. P., Golubev, V. B., Kononov, S. A., Kravchenko, E. A., Levichev, E. B., Onuchin, A. P., Serednyakov, S. I., Shtol, D. A., Skovpen, Y. I., Solodov, E. P., Cardini, A., Carpinelli, M., Chao, D. S. T., Cheng, C. H., Doll, D. A., Echenard, B., Flood, K., Hanson, J., Hitlin, D. G., Ongmongkolkul, P., Porter, F. C., Zhu, R. Y., Randazzo, N., De La Cruz Burelo, E., Zheng, Y., Campos, P., De Silva, M., Kathirgamaraju, A., Meadows, B., Pushpawela, B., Shi, Y., Sokoloff, M., Lopez Castro, G., Ciaschini, V., Franchini, P., Giacomini, F., Paolini, A., Calderon Polania, G. A., Laczek, S., Romanowicz, P., Szybinski, B., Czuchry, M., Flis, L., Harezlak, D., Kocot, J., Radecki, M., Sterzel, M., Szepieniec, T., Szymocha, T., Wójcik, P., Andreotti, M., Baldini, W., Calabrese, R., Carassiti, V., Cibinetto, G., Cotta Ramusino, A., Evangelisti, F., Gianoli, A., Luppi, E., Malaguti, R., Manzali, M., Melchiorri, M., Munerato, M., Padoan, C., Santoro, V., Tomassetti, L., Beretta, M. M., Biagini, M., Boscolo, M., Capitolo, E., de Sangro, R., Esposito, M., Felici, G., Finocchiaro, G., Gatta, M., Gatti, C., Guiducci, S., Lauciani, S., Patteri, P., Peruzzi, I., Piccolo, M., Raimondi, P., Rama, Matteo, Sanelli, C., Tomassini, S., Fabbricatore, P., Delepine, D., Reyes Santos, M. A., Chrzaszcz, M., Grzymkowski, R., Knap, P., Kotula, J., Lesiak, T., Ludwin, J., Michalowski, J., Pawlik, B., Rachwal, B., Stodulski, M., Wiechczynski, J., Witek, M., Zawiejski, L., Zdybal, M., Aushev, V. Y., Ustynov, A., Arnaud, N., Bambade, P., Beigbeder, C., Bogard, F., Borsato, M., Breton, D., Brossard, J., Burmistrov, L., Charlet, D., Chaumat, V., Dadoun, O., El Berni, M., Maalmi, J., Puill, V., Rimbault, C., Stocchi, A., Tocut, V., Variola, A., Wallon, S., Wormser, G., Grancagnolo, F., Ben Haim, E., Sitt, S., Baylac, M., Bourrion, O., Deconto, J. M., Gomez Martinez, Y., Monseu, N., Muraz, J. F., Real, J. S., Vescovi, C., Cenci, R., Jawahery, A., Roberts, D., Twedt, E. W., Cheaib, R., Lindemann, D., Nderitu, S., Patel, P., Robertson, S. H., Swersky, D., Warburton, A., Cuautle Flores, E., Toledo Sanchez, G., Biassoni, P., Bombelli, L., Citterio, M., Coelli, S., Fiorini, C., Liberali, V., Monti, M., Nasri, B., Neri, N., Palombo, F., Sabatini, F., Stabile, A., Berra, A., Giachero, A., Gotti, C., Lietti, D., Maino, M., Pessina, G., Prest, M., Martin, J. P., Simard, M., Starinski, N., Taras, P., Drutskoy, A., Makarychev, S., Nefediev, A. V., Aloisio, A., Cavaliere, S., De Nardo, G., Della Pietra, M., Doria, A., Giordano, R., Ordine, A., Pardi, S., Russo, G., Sciacca, C., Bigi, I. I., Jessop, C. P., Wang, W., Bellato, M., Benettoni, M., Corvo, M., Crescente, A., Dal Corso, F., Dosselli, U., Fanin, C., Gianelle, A., Longo, S., Michelotto, M., Montecassiano, F., Morandin, M., Pengo, R., Posocco, M., Rotondo, M., Simi, G., Stroili, R., Gaioni, L., Manazza, A., Manghisoni, M., Ratti, L., Re, V., Traversi, G., Zucca, S., Bizzaglia, S., Bizzarri, M., Cecchi, C., Germani, S., Lebeau, M., Lubrano, P., Manoni, E., Papi, A., Rossi, A., Scolieri, G., Batignani, Giovanni, Bettarini, Stefano, Casarosa, Giulia, Cervelli, A., Fella, A., Forti, Francesco, Giorgi, Marcello, Lilli, L., Lusiani, A., Oberhof, BENJAMIN JEROME ANDREAS, Paladino, Antonio, Pantaleo, F., Paoloni, Eugenio, Perez Perez, A. L., Rizzo, Giuliana, Walsh, J., Fernández Téllez, A., Beck, G., Berman, M., Bevan, A., Gannaway, F., Inguglia, G., Martin, A. J., Morris, J., Bocci, V., Capodiferro, M., Chiodi, G., Dafinei, I., Drenska, N. V., Faccini, R., Ferroni, F., Gargiulo, C., Gauzzi, P., Luci, C., Lunadei, R., Martellotti, G., Pellegrino, F., Pettinacci, V., Pinci, D., Recchia, L., Ruggeri, D., Zullo, A., Camarri, P., Cardarelli, R., De Santis, C., Di Ciaccio, A., Di Felice, V., Di Palma, F., Di Simone, A., Marcelli, L., Messi, R., Moricciani, D., Sparvoli, R., Tammaro, S., Branchini, P., Budano, A., Bussino, S., Ciuchini, M., Nguyen, F., Passeri, A., Ruggieri, F., Spiriti, E., Wilson, F., Leon Monzon, I., Millan Almaraz, J. R., Podesta Lerma, P. L. M., Aston, D., Dey, B., Fisher, A., Jackson, P. D., Leith, D. W. G. S., Luitz, S., Macfarlane, D., Mcculloch, M., Metcalfe, S., Novokhatski, A., Osier, S., Prepost, R., Ratcliff, B., Seeman, J., Sullivan, M., Va'Vra, J., Wienands, U., Wisniewski, W., Altschul, B. D., Purohit, M. V., Baudot, J., Ripp Baudot, I., Cirrone, G. A. P., Cuttone, G., Bezshyyko, O., Dolinska, G., Soffer, A., Bianchi, F., De Mori, F., Filippi, A., Gamba, D., Marcello, S., Bomben, M., Bosisio, L., Cristaudo, P., Lanceri, L., Liberti, B., Rashevskaya, I., Stella, C., Vallazza, E. S., Vitale, L., Auriemma, G., Satriano, C., Martinez Vidal, F., Mazorra de Cos, J., Oyanguren, A., Ruiz Valls, P., Beaulieu, A., Dejong, S., Franta, J., Lewczuk, M. J., Roney, M., Sobie, R., M., Baszczyk, P., Dorosz, J., Kolodziej, W., Kucewicz, M., Sapor, A., Jeremie, E., Grauges Pou, G. E., Bruno, G., De Roberti, D., Diacono, G., Donvito, P., Fusco, F., Gargano, F., Giordano, F., Loddo, F., Loparco, G. P., Maggi, V., Manzari, M. N., Mazziotta, E., Nappi, A., Palano, B., Santeramo, I., Sgura, L., Silvestri, V., Spinoso, G., Eigen, J., Zaliecka, Z., Zhu, L., Jenkovszky, G., Balbi, M., Boldini, D., Bonacorsi, V., Cafaro, I., D'Antone, G. M., Dallavalle, R., Di Sipio, F., Fabbri, L., Fabbri, A., Gabrielli, D., Galli, P., Giacomelli, V., Giordano, F. M., Giorgi, C., Grandi, I., Lax, S., Lo Meo, U., Marconi, A., Montanari, G., Pellegrini, M., Piccinini, T., Rovelli, N., Semprini Cesari, G., Torromeo, N., Tosi, R., Travaglini, V. M., Vagnoni, S., Valentinetti, M., Villa, A., Zoccoli, J. F., Caron, C., Hearty, P. F. T., Lu, T. S., Mattison, J. A., Mckenna, R. Y. C., So, Barnyakov, M. Y. u., V. E., Blinov, A. A., Botov, V. P., Druzhinin, V. B., Golubev, S. A., Kononov, E. A., Kravchenko, E. B., Levichev, A. P., Onuchin, S. I., Serednyakov, D. A., Shtol, Y. I., Skovpen, E. P., Solodov, A., Cardini, M., Carpinelli, D. S. T., Chao, C. H., Cheng, D. A., Doll, B., Echenard, K., Flood, J., Hanson, D. G., Hitlin, P., Ongmongkolkul, F. C., Porter, R. Y., Zhu, N., Randazzo, E., De La Cruz Burelo, Y., Zheng, P., Campo, M., De Silva, A., Kathirgamaraju, B., Meadow, B., Pushpawela, Y., Shi, M., Sokoloff, G., Lopez Castro, V., Ciaschini, P., Franchini, F., Giacomini, A., Paolini, G. A., Calderon Polania, S., Laczek, P., Romanowicz, B., Szybinski, M., Czuchry, L., Fli, D., Harezlak, J., Kocot, M., Radecki, M., Sterzel, T., Szepieniec, T., Szymocha, P., Wójcik, M., Andreotti, W., Baldini, R., Calabrese, V., Carassiti, G., Cibinetto, A., Cotta Ramusino, F., Evangelisti, A., Gianoli, E., Luppi, R., Malaguti, M., Manzali, M., Melchiorri, M., Munerato, C., Padoan, V., Santoro, L., Tomassetti, M. M., Beretta, M., Biagini, M., Boscolo, E., Capitolo, R., de Sangro, M., Esposito, G., Felici, G., Finocchiaro, M., Gatta, C., Gatti, S., Guiducci, S., Lauciani, P., Patteri, I., Peruzzi, M., Piccolo, P., Raimondi, M., Rama, C., Sanelli, S., Tomassini, P., Fabbricatore, D., Delepine, M. A., Reyes Santo, M., Chrzaszcz, R., Grzymkowski, P., Knap, J., Kotula, T., Lesiak, J., Ludwin, J., Michalowski, B., Pawlik, B., Rachwal, M., Stodulski, J., Wiechczynski, M., Witek, L., Zawiejski, M., Zdybal, V. Y., Aushev, A., Ustynov, N., Arnaud, P., Bambade, C., Beigbeder, F., Bogard, M., Borsato, D., Breton, J., Brossard, L., Burmistrov, D., Charlet, V., Chaumat, O., Dadoun, M., El Berni, J., Maalmi, V., Puill, C., Rimbault, A., Stocchi, V., Tocut, A., Variola, S., Wallon, G., Wormser, F., Grancagnolo, E., Ben Haim, S., Sitt, M., Baylac, O., Bourrion, J. M., Deconto, Y., Gomez Martinez, N., Monseu, J. F., Muraz, J. S., Real, C., Vescovi, R., Cenci, A., Jawahery, D., Robert, E. W., Twedt, R., Cheaib, D., Lindemann, S., Nderitu, P., Patel, S. H., Robertson, D., Swersky, A., Warburton, E., Cuautle Flore, G., Toledo Sanchez, P., Biassoni, L., Bombelli, M., Citterio, S., Coelli, C., Fiorini, V., Liberali, M., Monti, B., Nasri, N., Neri, F., Palombo, F., Sabatini, A., Stabile, A., Berra, A., Giachero, C., Gotti, D., Lietti, M., Maino, G., Pessina, M., Prest, J. P., Martin, M., Simard, N., Starinski, P., Tara, A., Drutskoy, S., Makarychev, A. V., Nefediev, A., Aloisio, Cavaliere, Sergio, G., De Nard, DELLA PIETRA, Massimo, A., Doria, Giordano, Raffaele, A., Ordine, S., Pardi, Russo, Guido, C., Sciacca, I. I., Bigi, C. P., Jessop, W., Wang, M., Bellato, M., Benettoni, M., Corvo, A., Crescente, F., Dal Corso, U., Dosselli, C., Fanin, A., Gianelle, S., Longo, M., Michelotto, F., Montecassiano, M., Morandin, R., Pengo, M., Posocco, M., Rotondo, G., Simi, R., Stroili, L., Gaioni, A., Manazza, M., Manghisoni, L., Ratti, V., Re, G., Traversi, S., Zucca, S., Bizzaglia, M., Bizzarri, C., Cecchi, S., Germani, M., Lebeau, P., Lubrano, E., Manoni, A., Papi, A., Rossi, G., Scolieri, G., Batignani, S., Bettarini, G., Casarosa, A., Cervelli, A., Fella, F., Forti, M., Giorgi, L., Lilli, A., Lusiani, B., Oberhof, A., Paladino, F., Pantaleo, E., Paoloni, A. L., Perez Perez, G., Rizzo, J., Walsh, A., Fernández Téllez, G., Beck, M., Berman, A., Bevan, F., Gannaway, G., Inguglia, A. J., Martin, J., Morri, V., Bocci, M., Capodiferro, G., Chiodi, I., Dafinei, N. V., Drenska, R., Faccini, F., Ferroni, C., Gargiulo, P., Gauzzi, C., Luci, R., Lunadei, G., Martellotti, F., Pellegrino, V., Pettinacci, D., Pinci, L., Recchia, D., Ruggeri, A., Zullo, P., Camarri, R., Cardarelli, C., De Santi, A., Di Ciaccio, V., Di Felice, F., Di Palma, A., Di Simone, L., Marcelli, R., Messi, D., Moricciani, R., Sparvoli, S., Tammaro, P., Branchini, A., Budano, S., Bussino, M., Ciuchini, F., Nguyen, A., Passeri, F., Ruggieri, E., Spiriti, F., Wilson, I., Leon Monzon, J. R., Millan Almaraz, P. L. M., Podesta Lerma, D., Aston, B., Dey, A., Fisher, P. D., Jackson, D. W. G. S., Leith, S., Luitz, D., Macfarlane, M., Mcculloch, S., Metcalfe, A., Novokhatski, S., Osier, R., Prepost, B., Ratcliff, J., Seeman, M., Sullivan, J., Va'Vra, U., Wienand, W., Wisniewski, B. D., Altschul, M. V., Purohit, J., Baudot, I., Ripp Baudot, G. A. P., Cirrone, G., Cuttone, O., Bezshyyko, G., Dolinska, A., Soffer, F., Bianchi, F., De Mori, A., Filippi, D., Gamba, S., Marcello, M., Bomben, L., Bosisio, P., Cristaudo, L., Lanceri, B., Liberti, I., Rashevskaya, C., Stella, E. S., Vallazza, L., Vitale, G., Auriemma, C., Satriano, F., Martinez Vidal, J., Mazorra de Co, A., Oyanguren, P., Ruiz Vall, A., Beaulieu, S., Dejong, J., Franta, M. J., Lewczuk, M., Roney, and R., Sobie

Subjects
Physics - Instrumentation and Detectors, High Energy Physics - Experiment
Abstract

In this Technical Design Report (TDR) we describe the SuperB detector that was to be installed on the SuperB e+e- high luminosity collider. The SuperB asymmetric collider, which was to be constructed on the Tor Vergata campus near the INFN Frascati National Laboratory, was designed to operate both at the Upsilon(4S) center-of-mass energy with a luminosity of 10^{36} cm^{-2}s^{-1} and at the tau/charm production threshold with a luminosity of 10^{35} cm^{-2}s^{-1}. This high luminosity, producing a data sample about a factor 100 larger than present B Factories, would allow investigation of new physics effects in rare decays, CP Violation and Lepton Flavour Violation. This document details the detector design presented in the Conceptual Design Report (CDR) in 2007. The R&D and engineering studies performed to arrive at the full detector design are described, and an updated cost estimate is presented. A combination of a more realistic cost estimates and the unavailability of funds due of the global economic climate led to a formal cancelation of the project on Nov 27, 2012.

Published
2013

30. Performance of upstream interaction region detectors for the FIRST experiment at GSI

Author

Valeria Sipala, Vincenzo Patera, A. Sciubba, C. Finck, M. C. Morone, Felice Iazzi, D. M. Rossi, Z. Abou-Haidar, María Isabel Gallardo, Piernicola Oliva, L. Stuttge, A. Boudard, M. Anelli, J. Krimmer, Herbert A. Simon, Marco Durante, Valeria Rosso, J. M. Quesada, R. Introzzi, M. A. Cortés-Giraldo, R. Pleskac, V. Monaco, G.A.P. Cirrone, E. Iarocci, Thomas Aumann, T. T. Bohlen, Francesco Romano, Paola Sala, Flavio Marchetto, A Le F{èvre, A. Paoloni, Nunzio Randazzo, M. A. G. Alvarez, M. Carpinelli, Eleuterio Spiriti, C Sfienti, Bruno Golosio, Yvonne Leifels, A. Bocci, Antonio Brunetti, Giacomo Cuttone, N. Kurz, M. Labalme, Luca Piersanti, M. Rousseau, S. Tropea, H. Younis, C. Agodi, Alessio Sarti, G. Ickert, Christoph Schuy, J. P. Fernández-García, Roberto Sacchi, S. Leray, M. De Napoli, D. Juliani, Giuseppe Battistoni, Universidad de Sevilla. Departamento de Física Atómica, Molecular y Nuclear, Z., Abou Haidar, C., Agodi, M. A. G., Alvarez, M., Anelli, T., Aumann, G., Battistoni, A., Bocci, T. T., Böhlen, A., Boudard, A., Brunetti, M., Carpinelli, G. A. P., Cirrone, M. A., Cortes Giraldo, G., Cuttone, M., De Napoli, Durante, Marco, J. P., Fernández García, C., Finck, M. I., Gallardo, B., Golosio, E., Iarocci, F., Iazzi, G., Ickert, R., Introzzi, D., Juliani, J., Krimmer, N., Kurz, M., Labalme, Y., Leifel, A., Le F{èvre, S., Leray, F., Marchetto, V., Monaco, M. C., Morone, P., Oliva, A., Paoloni, V., Patera, L., Piersanti, R., Pleskac, J. M., Quesada, N., Randazzo, F., Romano, D., Rossi, V., Rosso, M., Rousseau, R., Sacchi, P., Sala, A., Sarti, C., Schuy, A., Sciubba, C., Sfienti, H., Simon, V., Sipala, E., Spiriti, L., Stuttge, S., Tropea, H., Younis, Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Institut Pluridisciplinaire Hubert Curien (IPHC), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut de Physique Nucléaire de Lyon (IPNL), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de physique corpusculaire de Caen (LPCC), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-École Nationale Supérieure d'Ingénieurs de Caen (ENSICAEN), Normandie Université (NU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Normandie Université (NU)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Abou Haidar, Z, Agodi, C, Alvarez, M, Anelli, M, Aumann, T, Battistoni, G, Bocci, A, Bohlen, T, Boudard, A, Brunetti, A, Carpinelli, M, Cirrone, G, Cortes Giraldo, M, Cuttone, G, De Napol, I, Durante, M, Fernandez Garcia, J, Finck, C, Gallardo, M, Golosio, B, Iarocci, E, Iazzi, F, Ickert, G, Introzzi, R, Juliani, D, Krimmer, J, Kurz, N, Labalme, M, Leifels, Y, Le Fevre, A, Leray, S, Marchetto, F, Monaco, V, Morone, M, Oliva, P, Paoloni, A, Patera, V, Piersanti, L, Pleskac, R, Quesada, J, Randazzo, N, Romano, F, Rossi, D, Rosso, V, Rousseau, M, Sacchi, R, Sala, P, Sarti, A, Schuy, C, Sciubba, A, Sfienti, C, Simon, H, Sipala, V, Spiriti, E, Stuttge, L, Tropea, S, and Younis, H

Subjects
Wire chambers (MWPC, gas and liquid scintillators), Physics::Instrumentation and Detectors, 29.40.Mc, 29.40.Cs, 29.40.Gx, Electron, FIRST, 7. Clean energy, 01 natural sciences, Wire chambers(MWPC, Thin-gap chambers, drift chambers, drift tubes, proportional, chambers etc), Gaseous detectors, Scintillators, scintillation and light emission processes (solid, Particle tracking detectors (Gaseous detectors), 030218 nuclear medicine & medical imaging, 0302 clinical medicine, chambers etc), Detectors and Experimental Techniques, Nuclear Experiment, Instrumentation, drift tubes, Mathematical Physics, Physics, scintillation and light emission processes (solid, gas and liquid scintillators), Carbon-12, Scintillators, scintillation and light emission processes (solid, gas and liquid scintillators), Charged particle, Wire chambers (MWPC, Thin-gap chambers, drift chambers, drift tubes, proportional chambers etc), proportional chambers etc), proportional chambers etc) Particle tracking detectors (Gaseous detectors) Scintillators, Scintillators, article tracking detectors (Gaseous detectors), gas and liquid scintillators) Gaseous detectors, Wire chambers(MWPC, Thin-gap chambers, drift chambers, scintillation and light emission processes (solid, Scintillator, [PHYS.NEXP]Physics [physics]/Nuclear Experiment [nucl-ex], Wirechambers(MWPC,Thin-gapchambers,driftchambers,drifttubes,proportional chambers etc), Particle detector, Ion, proportional, Nuclear physics, 03 medical and health sciences, 0103 physical sciences, Gaseous detector, ddc:610, 010306 general physics, Settore FIS/07 - Fisica Applicata(Beni Culturali, Ambientali, Biol.e Medicin), Measuring instrument, Physics::Accelerator Physics, Beam (structure), particle tracking detectors (gaseous detectors), scintillators, wire chambers(mwpc, thin-gap chambers, wire chambers (mwpc, gaseous detectors
Abstract

Open Access.-- et al., The FIRST (Fragmentation of Ions Relevant for Space and Therapy) experiment at GSI has been designed to study carbon fragmentation, measuring 12C double differential cross sections (∂2σ/∂θ∂E) for different beam energies between 100 and 1000 MeV/u. The experimental setup integrates newly designed detectors in the, so called, Interaction Region around the graphite target. The Interaction Region upstream detectors are a 250 μm thick scintillator and a drift chamber optimized for a precise measurement of the ions interaction time and position on the target. In this article we review the design of the upstream detectors along with the preliminary results of the data taking performed on August 2011 with 400 MeV/u fully stripped carbon ion beam at GSI. Detectors performances will be reviewed and compared to those obtained during preliminary tests, performed with 500 MeV electrons (at the BTF facility in the INFN Frascati Laboratories) and 80 MeV/u protons and carbon ions (at the INFN LNS Laboratories in Catania)., This work has been supported by the European Community FP7 - Capacities, contract ENSAR nº 262010. This work was also supported by Junta de Andalucia and the Spanish Ministerio de Ciencia e Innovacion Contracts P07-FQM-02894, FIS2008-04189 and FPA2008-04972-C03.

Published
2012
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31. The FIRST experiment at GSI

Author

G. Ickert, A. Bocci, Herbert A. Simon, C. Agodi, Francesco Romano, A. Paoloni, M. Carpinelli, M. Rousseau, Eleuterio Spiriti, Christoph Schuy, C. Finck, C. Scheidenberger, Alessio Sarti, J. Krimmer, Roberto Sacchi, Yvonne Leifels, Valeria Sipala, Z. Abou-Haidar, M. C. Morone, N. Kurz, Luca Piersanti, Felice Iazzi, H. Younis, Piernicola Oliva, D. M. Rossi, Giacomo Cuttone, Marco Durante, M. Labalme, C. Sfienti, J. M. Quesada, L. Stuttge, R. Pleskac, S. Leray, V. Monaco, G.A.P. Cirrone, Antonio Brunetti, E. Iarocci, Vincenzo Patera, A. Sciubba, S. Tropea, Paola Sala, M. A. G. Alvarez, J. P. Fernández-García, G. Raciti, María Isabel Gallardo, A. Le Fèvre, D. Juliani, R. Introzzi, Giuseppe Battistoni, M. A. Cortés-Giraldo, Flavio Marchetto, Thomas Aumann, A. Boudard, M. De Napoli, Nunzio Randazzo, Bruno Golosio, T. T. Bohlen, R., Pleskac, Z., Abou Haidar, C., Agodi, M. A. G., Alvarez, T., Aumann, G., Battistoni, A., Bocci, T. T., Böhlen, A., Boudard, A., Brunetti, M., Carpinelli, G. A. P., Cirrone, M. A., Cortes Giraldo, G., Cuttone, M., De Napoli, Durante, Marco, J. P., Fernández García, C., Finck, B., Golosio, M. I., Gallardo, E., Iarocci, F., Iazzi, G., Ickert, R., Introzzi, D., Juliani, J., Krimmer, N., Kurz, M., Labalme, Y., Leifel, A., Le Fevre, S., Leray, F., Marchetto, V., Monaco, M. C., Morone, P., Oliva, A., Paoloni, L., Piersanti, J. M., Quesada, G., Raciti, N., Randazzo, F., Romano, D., Rossi, M., Rousseau, R., Sacchi, P., Sala, A., Sarti, C., Scheidenberger, C., Schuy, A., Sciubba, C., Sfienti, H., Simon, V., Sipala, E., Spiriti, L., Stuttge, S., Tropea, H., Youni, V., Patera, Département de Physique Nucléaire (ex SPhN) (DPHN), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Institut Pluridisciplinaire Hubert Curien (IPHC), Université de Strasbourg (UNISTRA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut de Physique Nucléaire de Lyon (IPNL), Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Laboratoire de physique corpusculaire de Caen (LPCC), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-École Nationale Supérieure d'Ingénieurs de Caen (ENSICAEN), Normandie Université (NU)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Normandie Université (NU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Pleskac, R, Abou Haidar, Z, Agodi, C, Alvarez, M, Aumann, T, Battistoni, G, Bocci, A, Bohlen, T, Boudard, A, Brunetti, A, Carpinelli, M, Cirrone, G, Cortes Giraldo, M, Cuttone, G, De Napoli, M, Durante, M, Fernandez Garcia, J, Finck, C, Golosio, B, Gallardo, M, Iarocci, E, Iazzi, F, Ickert, G, Introzzi, R, Juliani, D, Krimmer, J, Kurz, N, Labalme, M, Leifels, Y, Le Fevre, A, Leray, S, Marchetto, F, Monaco, V, Morone, M, Oliva, P, Paoloni, A, Piersanti, L, Quesada, J, Raciti, G, Randazzo, N, Romano, F, Rossi, D, Rousseau, M, Sacchi, R, Sala, P, Sarti, A, Scheidenberger, C, Schuy, C, Sciubba, A, Sfienti, C, Simon, H, Sipala, V, Spiriti, E, Stuttge, L, Tropea, S, Younis, H, and Patera, V

Subjects
Nuclear and High Energy Physics, Ion beam, Physics::Instrumentation and Detectors, medicine.medical_treatment, Nuclear physics, [PHYS.NEXP]Physics [physics]/Nuclear Experiment [nucl-ex], Scintillator, Elementary-particle, FIRST, 7. Clean energy, 01 natural sciences, Particle detector, Wire chamber, Dipole magnet, Fragmentation, PARTICLE THERAPY, hadrontherapy, fragmentation, nuclear physics, elementary-particle, instrumentation, experimental methods, Hadrontherapy, 0103 physical sciences, medicine, Neutron detection, ddc:530, Gaseous detector, ION-BEAM, 010306 general physics, Nuclear Experiment, DETECTOR, Instrumentation, GEANT4, FLUKA CODE, FRAGMENTATION, BENCHMARKING, RADIOTHERAPY, TRANSPORT, Physics, Particle therapy, Time projection chamber, 010308 nuclear & particles physics, Experimental methods, Detector, Settore FIS/07 - Fisica Applicata(Beni Culturali, Ambientali, Biol.e Medicin)
Abstract

The FIRST (Fragmentation of Ions Relevant for Space and Therapy) experiment at the SIS accelerator of GSI laboratory in Darmstadt has been designed for the measurement of ion fragmentation cross-sections at different angles and energies between 100 and 1000 MeV/nucleon. Nuclear fragmentation processes are relevant in several fields of basic research and applied physics and are of particular interest for tumor therapy and for space radiation protection applications. The start of the scientific program of the FIRST experiment was on summer 2011 and was focused on the measurement of 400 MeV/nucleon 12C beam fragmentation on thin (8 mm) graphite target. The detector is partly based on an already existing setup made of a dipole magnet (ALADiN), a time projection chamber (TP-MUSIC IV), a neutron detector (LAND) and a time of flight scintillator system (TOFWALL). This pre-existing setup has been integrated with newly designed detectors in the Interaction Region, around the carbon target placed in a sample changer. The new detectors are a scintillator Start Counter, a Beam Monitor drift chamber, a silicon Vertex Detector and a Proton Tagger scintillator system optimized for the detection of light fragments emitted at large angles. In this paper we review the experimental setup, then we present the simulation software, the data acquisition system and finally the trigger strategy of the experiment., This work has been supported by the European Community FP7 - Capacities, contract ENSAR n° 262010. This work was also supported by Junta de Andalucia and the Spanish Ministerio de Ciencia e Innovacion Contracts P07-FQM-02894, FIS2008-04189 and FPA2008-04972-C03.

Published
2012
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32. Characterization of an In-Beam PET Prototype for Proton Therapy With Different Target Compositions

Author

Sara Vecchio, F. Attanasi, S. Moehrs, Alberto Del Guerra, Piero Lojacono, Nico Lanconelli, Francesco Romano, Valeria Rosso, G.A.P. Cirrone, Nicola Belcari, Giacomo Cuttone, A. Del Guerra, F. Attanasi, N. Belcari, S. Moehr, V. Rosso, S. Vecchio, G. A. P. Cirrone, G. Cuttone, P. Lojacono, S. Romano, N. Lanconelli, Attanasi F, Belcari N, Moehrs S, Rosso V, Vecchio S, Cirrone GAP, Cuttone G, Lojacono P, Romano F, Lanconelli N, and Del Guerra A

Subjects
Nuclear and High Energy Physics, medicine.medical_specialty, Materials science, medicine.diagnostic_test, Iterative reconstruction, Lyso, Imaging phantom, Nuclear Energy and Engineering, Positron emission tomography, medicine, Dosimetry, Medical physics, Tomography, Positron emission, Electrical and Electronic Engineering, Proton therapy, Biomedical engineering
Abstract

Ion treatment can deliver an accurate and effective therapy. The verification of the delivered dose, after each irradiation, is an information that can improve the effectiveness of the complete treatment, if a comparison of the planned with the delivered dose is foreseen. A possible way to do this verification is measuring the beta+ emitters, like 11-C, 15-O, 10-C that are generated in irradiated tissues by nuclear reactions, by using a positron emission tomography (PET) system. We have realized a PET prototype based on two planar heads; each head is made up of a position sensitive photomultiplier coupled to a square matrix of same size of LYSO scintillating crystals (2x2x18 mm3 pixel dimensions for a total area of 5x5 cm2). A special resistive chain and a dedicated electronic board that performs signal amplification and digitization were realized. A 3D Maximum Likelihood Expectation Maximization reconstruction program that uses all of the collected lines-of-response was implemented. This prototype was tested at the INFN-LNS proton facility in Catania (Italy), where clinical treatment of ocular pathologies in patients is performed. In this paper we present: the results obtained for the range monitoring in monoenergetic and extended proton irradiations of homogeneous PMMA cylinders; the dependence on different density values and stoichiometry with inhomogeneous phantoms; the spatial relationship between the dose distribution and its PET image.

Published
2010

33. A PET prototype for in-beam monitoring of proton therapy

Author

M. Camarda, Nicola Belcari, F. Di Rosa, Sara Vecchio, Nico Lanconelli, A. Del Guerra, Giacomo Cuttone, S. Moehrs, Giorgio Ivan Russo, F. Attanasi, Valeria Rosso, G. A. Pablo Cirrone, S. Vecchio, F. Attanasi, N. Belcari, M. Camarda, G. A. P. Cirrone, G. Cuttone, A. Del Guerra, F. Di Rosa, S. Moehr, N. Lanconelli, V. Rosso, G. Russo, Vecchio S., Attanasi F., Belcari N., Camarda M., Cirrone G. A. P., Cuttone G., Di Rosa F., Lanconelli N., Moehrs S., Rosso V., Russo G., and Del Guerra A.

Subjects
Nuclear and High Energy Physics, Photomultiplier, Materials science, business.industry, Lyso, Optics, Planar, Nuclear Energy and Engineering, Beamline, Dosimetry, Positron emission, Tomography, Electrical and Electronic Engineering, Nuclear medicine, business, Proton therapy, Beam (structure)
Abstract

The in-beam PET is a novel PET application to image the beta+ activity induced in biological tissues by hadronic therapeutic beams. Thanks to the correlation existing between beam-delivered dose profiles and beam-induced activity profiles, in vivo information about the effective ion paths can be extracted from the in-beam PET image. In-situ measurements, immediately after patient irradiation, are recommended in order to exploit the maximum statistics, by detecting the contribution provided by short lived isotopes. A compact, dedicated tomograph should then be developed for such an application, so as to be used in the treatment room. We have realized a small PET prototype in order to demonstrate the feasibility of such technique for the monitoring of proton therapy of ocular tumors at the CATANA facility (Catania, Italy). The DoPET (dosimetry with a positron emission Tomograph) tomograph consists of two planar heads, with an active area of about 5 cm x 5 cm. Each head is made up of a squared position sensitive photomultiplier (Hamamatsu H8500) coupled to a matrix of the same size of LYSO scintillating crystals (2 mm times 2 mm times 18 mm pixel dimensions). Dedicated, compact electronic boards are used for the signal multiplexing, amplification and digitization. The distance between the pair can be set from 10 cm up to a maximum of about 20 cm. The validation of the prototype was performed using 62 MeV protons at the CATANA beam line and plastic phantoms. Different dose distributions have been delivered and a good correlation between the distal fall-off of the activity profiles and of the dose profiles was found, i.e., better than 2 mm along the beam direction.

Published
2007

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