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1. Procedures and results of the measurements on large area photomultipliers for the NEMO project

Author

C. Sollima, E. Leonora, G. Carminati, M. Circella, Alberto Rovelli, F. Lucarelli, Piera Sapienza, M. Bazzotti, S. Minutoli, F. Raffaelli, V. Flaminio, Tommaso Chiarusi, M. Costa, Manuela Vecchi, Sebastiano Aiello, G. Giacomelli, Paolo Musico, G. DeBonis, Paolo Piattelli, G. Raia, Antonio Capone, Fabio Stefani, Antonio D'Amico, Maurizio Spurio, S. Russo, Mario Musumeci, G. Giovanetti, N. Randazzo, S. Galeotti, A. Orlando, V. Pappalardo, I. Amore, G. Cacopardo, Giorgio Riccobene, L. Caponetto, M. Battaglieri, E. Shirokov, Rosanna Cocimano, D. LoPresti, C. Calì, S. Reito, F. Maugeri, R. Coniglione, M. Cordelli, S. Urso, E. Barbarito, Alberto Aloisio, M. Ripani, G. C. Barbarino, Francesco Simeone, Valeria Sipala, M. Osipenko, A. Ceres, G. DeRosa, M. Imbesi, A. Grimaldi, D. Piombo, M. Anghinolfi, Nicolo' Beverini, Enzo Gandolfi, R. DeVita, Emilio Migneco, G. Ricco, A. Grmek, G.V. Russo, M. Mongelli, A. Martini, G. Terreni, M. Morganti, S. Biagi, Ralf Wischnewski, M. Ruppi, B. Bouhdaef, B. Cassano, D. Sciliberto, M. Bonori, Piero Vicini, F. Ameli, A. Bersani, A. Marinelli, M. Sedita, K. Fratini, M. Taiuti, R. Habel, C. Distefano, L. Trasatti, Federico M. Giorgi, A. Anzalone, Annarita Margiotta, Roberto Bellotti, R. Masullo, G. DeRuvo, Riccardo Papaleo, Alessandro Lonardo, Alessandro Gabrielli, S., Aiello, E., Leonora, Aloisio, Alberto, F., Ameli, I., Amore, M., Anghinolfi, A., Anzalone, Barbarino, Giancarlo, E., Barbarito, M., Battaglieri, M., Bazzotti, R., Bellotti, A., Bersani, N., Beverini, S., Biagi, M., Bonori, B., Bouhdaef, G., Cacopardo, C., Calı, A., Capone, L., Caponetto, G., Carminati, B., Cassano, A., Cere, T., Chiarusi, M., Circella, R., Cocimano, R., Coniglione, M., Cordelli, M., Costa, A., D’Amico, G., Deboni, DE ROSA, Gianfranca, G., Deruvo, R., Devita, C., Distefano, V., Flaminio, K., Fratini, A., Gabrielli, S., Galeotti, E., Gandolfi, G., Giacomelli, F., Giorgi, G., Giovanetti, A., Grimaldi, A., Grmek, R., Habel, M., Imbesi, A., Lonardo, D., Lopresti, F., Lucarelli, A., Margiotta, A., Marinelli, A., Martini, R., Masullo, F., Maugeri, E., Migneco, S., Minutoli, M., Mongelli, M., Morganti, P., Musico, M., Musumeci, A., Orlando, M., Osipenko, R., Papaleo, V., Pappalardo, P., Piattelli, D., Piombo, F., Raffaelli, G., Raia, N., Randazzo, S., Reito, G., Ricco, G., Riccobene, M., Ripani, A., Rovelli, M., Ruppi, G. V., Russo, S., Russo, P., Sapienza, M., Sedita, E., Shirokov, F., Simeone, D., Sciliberto, V., Sipala, C., Sollima, M., Spurio, F., Stefani, M., Taiuti, G., Terreni, L., Trasatti, S., Urso, M., Vecchi, P., Vicini, R., Wischnewski, DIP. DI FISICA, DIPARTIMENTO DI FISICA E ASTRONOMIA 'AUGUSTO RIGHI', and Facolta' di SCIENZE MATEMATICHE FISICHE e NATURALI

Subjects
LARGE AREA PHOTO-DETECTOR, PHOTOMULTIPLIER, NEUTRINO TELESCOPE, Pulsed laser, Physics, light detection, Nuclear and High Energy Physics, Photomultiplier, photomultiplier, Dark count rate, business.industry, Neutrino telescope, neutrino telescope, Large area photo-detector, large area photo-detector, Overall response rate, Optics, Underwater, Spurious relationship, business, Instrumentation, Voltage
Abstract

none 104 The selection of the photomultiplier plays a crucial role in the R&D activity related to a large-scale underwater neutrino telescope. This paper illustrates the main procedures and facilities used to characterize the performances of 72 large area photomultipliers, Hamamatsu model R7081 sel. The voltage to achieve a gain of 5×107, dark count rate and single photoelectron time and charge properties of the overall response were measured with a properly attenuated 410 nm pulsed laser. A dedicated study of the spurious pulses was also performed. The results prove that the photomultipliers comply with the general requirements imposed by the project. ISSN 0168-9002 doi:10.1016/j.nima.2009.12.040 none S. AIELLO; A. ALOISIO; F. AMELI; I.AMORE; M. ANGHINOLFI; A. ANZALONE; G. BARBARINO; E. BARBARITO; M.BATTAGLIERI; M.BAZZOTTI; R. BELLOTTI; A. BERSANI; N. BEVERINI; S. BIAGI; M. BONORI; B. BOUHDAEF; M. BRESCIA; G. CACOPARDO; C. CALÌ; A. CAPONE; L. CAPONETTO; G. CARMINATI; B. CASSANO; E. CASTORINA; A. CERES; T. CHIARUSI; M. CIRCELLA; R. COCIMANO; R. CONIGLIONE; M. CORDELLI; M. COSTA; A. DAMICO; C. DAMATO; V. DAMATO; G. DE BONIS; G. DE ROSA; G. DE RUVO; R. DE VITA; C. DISTEFANO; E. FALCHINI; V. FLAMINIO; K. FRATINI; GABRIELLI A; S. GALEOTTI; E. GANDOLFI; G. GIACOMELLI; F. GIORGI; G. GIOVANETTI; A. GRIMALDI; A. GRMEK; R. HABEL; E. LEONORA; A. LONARDO; G. LONGO; D. LO PRESTI; F. LUCARELLI; L. MACCIONE; A. MARGIOTTA; A. MARTINI; R. MASULLO; F. MAUGERI; R. MEGNA; E. MIGNECO; S. MINUTOLI; M. MONGELLI; T. MONTARULI; M. MORGANTI; P. MUSICO; M. MUSUMECI; C.A. NICOLAU; A. ORLANDO; M. OSIPENKO; G. OSTERIA; R. PAPALEO; V. PAPPALARDO; C. PETTA; P. PIATTELLI; D. PIOMBO; G. RAIA; N. RANDAZZO; S. REITO; G. RICCO; G. RICCOBENE; M. RIPANI; A. ROVELLI; M. RUPPI; G.V. RUSSO; S. RUSSO; P. SAPIENZA; M. SEDITA; E. SHIROKOV; F. SIMEONE; V. SIPALA; C. SOLLIMA; F. SPEZIALE; M. SPURIO; M. TAIUTI; G. TERRENI; L. TRASATTI; S. URSO; V. VALENTE; M. VECCHI; P. VICINI; R. WISCHNEWSKI S. AIELLO; A. ALOISIO; F. AMELI; I.AMORE; M. ANGHINOLFI; A. ANZALONE; G. BARBARINO; E. BARBARITO; M.BATTAGLIERI; M.BAZZOTTI; R. BELLOTTI; A. BERSANI; N. BEVERINI; S. BIAGI; M. BONORI; B. BOUHDAEF; M. BRESCIA; G. CACOPARDO; C. CALÌ; A. CAPONE; L. CAPONETTO; G. CARMINATI; B. CASSANO; E. CASTORINA; A. CERES; T. CHIARUSI; M. CIRCELLA; R. COCIMANO; R. CONIGLIONE; M. CORDELLI; M. COSTA; A. DAMICO; C. DAMATO; V. DAMATO; G. DE BONIS; G. DE ROSA; G. DE RUVO; R. DE VITA; C. DISTEFANO; E. FALCHINI; V. FLAMINIO; K. FRATINI; GABRIELLI A; S. GALEOTTI; E. GANDOLFI; G. GIACOMELLI; F. GIORGI; G. GIOVANETTI; A. GRIMALDI; A. GRMEK; R. HABEL; E. LEONORA; A. LONARDO; G. LONGO; D. LO PRESTI; F. LUCARELLI; L. MACCIONE; A. MARGIOTTA; A. MARTINI; R. MASULLO; F. MAUGERI; R. MEGNA; E. MIGNECO; S. MINUTOLI; M. MONGELLI; T. MONTARULI; M. MORGANTI; P. MUSICO; M. MUSUMECI; C.A. NICOLAU; A. ORLANDO; M. OSIPENKO; G. OSTERIA; R. PAPALEO; V. PAPPALARDO; C. PETTA; P. PIATTELLI; D. PIOMBO; G. RAIA; N. RANDAZZO; S. REITO; G. RICCO; G. RICCOBENE; M. RIPANI; A. ROVELLI; M. RUPPI; G.V. RUSSO; S. RUSSO; P. SAPIENZA; M. SEDITA; E. SHIROKOV; F. SIMEONE; V. SIPALA; C. SOLLIMA; F. SPEZIALE; M. SPURIO; M. TAIUTI; G. TERRENI; L. TRASATTI; S. URSO; V. VALENTE; M. VECCHI; P. VICINI; R. WISCHNEWSKI

Published
2010

2. Global impact of prescription opioid misuse: Europe and U.S

Author

Jody L. Green, G. Deruvo, KE Mcbride, E.M. Martinez, Stefan Walcher, Theodore J. Cicero, H Desel, G Milanesi, Icro Maremmani, Andrew Rosenblum, Richard C. Dart, F Sesana, Marilena Guareschi, Mark Parrino, and Lorenzo Somaini

Subjects
Pharmacology, medicine.medical_specialty, business.industry, Codeine, Toxicology, Hydromorphone, Heroin, Psychiatry and Mental health, Hydrocodone, Oxymorphone, medicine, Pharmacology (medical), Psychiatry, business, Oxycodone, medicine.drug, Buprenorphine, Methadone
Abstract

s / Drug and Alcohol Dependence 146 (2015) e118–e201 e129 Global impact of prescription opioid misuse: Europe and U.S. J.L. Green1, E.M. Martinez1, Andrew Rosenblum1, Theodore Cicero1, Richard Dart1, S. Walcher2, L. Somaini3, G. Deruvo3, H. Desel4, G. Milanesi5, F. Sesana5, M. Guareschi6, K. McBride1, I. Maremmani7, M. Parrino1 1 RADARS(r) System, RMPDC, DHHA, Denver, CO, United States 2 CONCEPT, Munich, Italy 3 SerT (Biella & Bitonto), Biella, Italy 4 GIZ-Nord Poisons Centre, Gottingen, Germany 5 Milan Poison Centre, Milan, Italy 6 AU-CNS, Pietrsanta, Italy 7 Santa Chiara University Hospital, Pisa, Italy Aims: Describe prescription opioid misuse reports to poison centres (PC) in Gottingen(Germany), Milan(Italy), and US, and by patients entering treatment programs (TP) for opioid addiction in Munich, Piemonte & Puglia, and US. Methods: PC: intentional exposures reported in 2012 for buprenorphine, methadone, and oxycodone. TP: self-reports of drug use “to get high” by patients entering therapy from Jan2012–Jun2013 for buprenorphine, methadone, oxycodone, codeine, fentanyl, morphine, hydrocodone, hydromorphone, oxymorphone, and tramadol (heroin DNS). Results: Germany: 70% of PC calls were intentional exposures and 57% suicidal intent, methadone was most frequent (46%). 48% of TP patients reported prescription opioid as their primary drug, methadone was most frequent (36%). Italy: 77% of PC calls were intentional exposureswith51%misuseand49%suicide,methadone was most frequent (51%). 36% of TP patients reported prescription opioid as their primary drug, buprenorphine was most frequent (43%). US: 62% of PC calls were intentional exposures and 52% suicidal intent, oxycodonewasmost frequent (71%); 46%of TPpatients reported prescription opioid as their primary drug, oxycodone was most frequent (52%). Conclusions: Data from PC and TP in Germany, Italy, and US illustrate similar patterns of prescription opioid misuse, a sizable minority report a prescription opioid as their primary drug. Drugs typically prescribed for treatment of opioid addiction are more misused in Europe while oxycodone is the drug of choice in the US. Financial support: The RADARS® System is part of Denver Health and Hospital Authority, a division of the state of Colorado. It is supported by subscriptions from pharmaceutical manufacturers. http://dx.doi.org/10.1016/j.drugalcdep.2014.09.268 A preclinical model of natural reward devaluation in cocaine addiction: Effects of dose Jennifer Green, Linda Dykstra, Regina M. Carelli University of North Carolina, Chapel Hill, NC, United

Published
2015

3. SY15-4 * PRESCRIPTION OPIOIDS IN SOUTHERN EUROPE: FRANCE

Author

Icro Maremmani, L. Somaini, R. Martinez-Riera, D. Touzeau, D. Martines, Marta Torrens, P. Rossi, Jody L. Green, G. Deruvo, S. Walcher, and Fernando Rodríguez de Fonseca

Subjects
medicine.medical_specialty, Prescription Drug Misuse, business.industry, Codeine, General Medicine, Fentanyl, Heroin, Opioid, medicine, Medical prescription, Psychiatry, business, Buprenorphine, medicine.drug, Methadone
Abstract

Background. Prescription opioid misuse in an increasing public health in many countries. The objective is to assess the prevalence of prescription opioid misuse in four European countries. Data from France are presented. Methods. Cross-sectional study. The rates of prescription drug misuse have been assessed using patient self-report at treatment program intake. Patients have been asked to self-report the use of use and injection history for European-market prescription opioids, prescription stimulants, and heroin, during the past 30-day. Also, basic demographic information, treatment history, and health care worker status have been recorded. Results. In France, a final sample of 144 subjects (77% males; 38,9years old) was recruited. The were 62,5% in treatment for heroin dependence; the rest (7) has as a main drug buprenorphine, codeine, methadone, morphine, fentanyl and tramadol. The main opioid abused drug during the last month was heroin, followed by buprenorphine, codeine, methadone and morphine. Those previously in treatment endorsed significantly less drugs, and less past 30-day use of buprenorphine. Buprenorphine is the preferred first line medication for French opioid rehabilitation patients. Conclusions. Preliminary data show that besides heroin, there is a concomitant abuse of prescription opioids. The knowledge of drug use patterns can provide useful information to develop effective prevention and treatment.

Published
2014

4. SY15-3 * PRESCRIPTION OPIOIDS IN SOUTHERN EUROPE: SPAIN

Author

S. Walcher, P. Rossi, Fernando Rodríguez de Fonseca, Jody L. Green, G. Deruvo, R. Martinez-Riera, Marta Torrens, D. Martinez-Sanvisens, L. Somain, Icro Maremmani, and D. Touzeau

Subjects
medicine.medical_specialty, Prescription Drug Misuse, business.industry, Codeine, Opium, General Medicine, Fentanyl, Heroin, medicine, Medical prescription, Psychiatry, business, medicine.drug, Methadone, Buprenorphine
Abstract

Background. Prescription opioid misuse in an increasing public health in many countries. The objective is to assess the prevalence of prescription opioid misuse in four European countries: France, Germany, Italy and Spain. Data form Sapin are presented Methods. Cross-sectional study. The rates of prescription drug misuse have been assessed using patient self-report at treatment program intake. Patients have been asked to self-report the use of use and injection history for European-market prescription opioids, prescription stimulants, and heroin, during the past 30-day. Also, basic demographic information, treatment history, and health care worker status have been recorded. Results. In Spain, a final sample of 125 subjects (78% males; 39 + 10 years old) was recruited. The 94% were in treatment for heroin dependence; the rest (7) has as a main drug methadone, tramadol, codeine, pethidine and opium. The main opioid abused drug during the last month was heroin (63%), followed by methadone, tramadol, codeine, pethidine, fentanyl, buprenorphine, morphine and metylphenidate. Conclusions. Preliminary data show that besides heroin, in Spain, there is a concomitant abuse of prescription opioids. The knowledge of drug use patterns can provide useful information to develop effective prevention and treatment.

Published
2014

5. SY15-2 * PAIN KILLERS AND SUBSTITUTION MEDICATIONS USE IN PATIENTS LOOKING FOR AGONIST OPIOID TREATMENT IN NORTHERN AND SOUTHERN ITALY, USING A 18-MONTH SURVEY METHODOLOGY

Author

Angelo Giovanni Icro Maremmani, Icro Maremmani, G. Deruvo, L. Somain, and Marilena Guareschi

Subjects
medicine.medical_specialty, Substance dependence, business.industry, Addiction, media_common.quotation_subject, General Medicine, medicine.disease, Heroin, Substance abuse, Opioid, Medicine, Medical prescription, business, Psychiatry, Buprenorphine, medicine.drug, media_common, Methadone
Abstract

Background. This presentation reports the prevalence of the opioid primary substance of abuse in patients entering drug-addiction treatment in Italy stressing geographical differences between Northern and Southern Italy. Methods. This was a cross-sectional observational study. The data was collected prospectively, during the years 2012–2013. The Opioids' Survey Questionnaire was administered in a 18-month survey to all patients entering all kind of drug-addiction treatment in two National Health Drug Addiction Units, in Northern and Southern Italy. Results. Substitution medication (methadone and buprenorphine) were the most utilized primary substances of abuse when patients were looking for an Agonist Opioid Treatment. This use is higher in Northern Italy than in Southern Italy. The use of Pain Killers was less frequent. Combined use of heroin, pain killers and medication was more frequent in Northern Italy. Conclusions. Geographical and cultural aspects may be involved in combined use of street opioids, diverted substitution medications and pain killers (prescription opioids) before entering an Opioid Agonist Treatment.

Published
2014

6. The NEMO project: A status report

Author

Taiuti, M., Aiello, S., Fabrizio, Ameli, Amore, I., Anghinolfi, M., Anzalone, A., Barbarino, G., Battaglieri, M., Bazzotti, M., Bersani, A., Beverini, N., Biagi, S., Bonori, Maurizio, Bouhdaef, B., Brunoldi, M., Cacopardo, G., Capone, Antonio, Caponetto, L., Carminati, G., Chiarusi, T., Circella, M., Cocimano, R., Coniglione, R., Cordelli, M., Costa, M., D'Amico, A., DE BONIS, Giulia, De Rosa, G., De Ruvo, G., De Vita, R., Distefano, C., Falchini, E., Flaminio, V., Fratini, K., Gabrielli, A., Galata, S., Galat, S., Gandolfi, E., Giacomelli, G., Giorgi, F., Giovanetti, G., Grimaldi, A., Habel, R., Imbesi, M., Kulikovsky, V., Lattuada, D., Leonora, E., Lonardo, A., Lo Presti, D., Lucarelli, Fabrizio, Margiotta, A., Marinelli, A., Martini, A., Masullo, Rocco, Migneco, E., Minutoli, S., Morganti, M., Musico, P., Musumeci, M., Nicolau, C. A., Orlando, A., Osipenko, M., Papaleo, R., Pappalardo, V., Piattelli, P., Piombo, D., Raia, G., Randazzo, N., Reito, S., Ricco, G., Riccobene, G., Ripani, M., Rovelli, A., Ruppi, M., Russo, G. V., Russo, S., Sapienza, P., Sciliberto, D., Sedita, M., Shirokov, E., Simeone, Francesco, Sipala, V., Spurio, M., Trasatti, L., Urso, S., Vecchi, Manuela, Vicini, P., Wischnewski, R., M., Taiuti, S., Aiello, F., Ameli, I., Amore, M., Anghinolfi, A., Anzalone, Barbarino, Giancarlo, M., Battaglieri, M., Bazzotti, A., Bersani, N., Beverini, S., Biagi, M., Bonori, B., Bouhdaef, M., Brunoldi, G., Cacopardo, A., Capone, L., Caponetto, G., Carminati, T., Chiarusi, M., Circella, R., Cocimano, R., Coniglione, M., Cordelli, M., Costa, A., D???amico, G., De Boni, DE ROSA, Gianfranca, G., De Ruvo, R., De Vita, C., Distefano, E., Falchini, V., Flaminio, K., Fratini, A., Gabrielli, S., Galatà, E., Gandolfi, G., Giacomelli, F., Giorgi, G., Giovanetti, A., Grimaldi, R., Habel, M., Imbesi, V., Kulikovsky, D., Lattuada, E., Leonora, A., Lonardo, D., Lo Presti, F., Lucarelli, A., Margiotta, A., Marinelli, A., Martini, R., Masullo, E., Migneco, S., Minutoli, M., Morganti, P., Musico, M., Musumeci, C. A., Nicolau, A., Orlando, M., Osipenko, R., Papaleo, V., Pappalardo, P., Piattelli, D., Piombo, G., Raia, N., Randazzo, S., Reito, G., Ricco, G., Riccobene, M., Ripani, A., Rovelli, M., Ruppi, G. V., Russo, S., Russo, P., Sapienza, D., Sciliberto, M., Sedita, E., Shirokov, F., Simeone, V., Sipala, M., Spurio, L., Trasatti, S., Urso, M., Vecchi, P., Vicini, R., Wischnewski, M. Taiuti, S.Aiello, F.Ameli, I.Amore, M.Anghinolfi, A.Anzalone, G.Barbarino, M. Battaglieri, M.Bazzotti, A.Bersani, N.Beverini, S.Biagi, M.Bonori, B.Bouhdaef, M. Brunoldi, G.Cacopardo, A.Capone, L.Caponetto, G.Carminati, T.Chiarusi, M.Circella, R. Cocimano, R.Coniglione, M.Cordelli, M.Costa, A.D’Amico, G.DeBonis, G.DeRosa, G. DeRuvo, R.DeVita, C.Distefano, E.Falchini, V.Flaminio, K.Fratini, A.Gabrielli, S. Galata, E.Gandolfi, G.Giacomelli, F.Giorgi, G.Giovanetti, A.Grimaldi, R.Habel, M. Imbesi, V.Kulikovsky, D.Lattuada, E.Leonora, A.Lonardo, D.LoPresti, F.Lucarelli, A. Margiotta, A.Marinelli, A.Martini, R.Masullo, E.Migneco, S.Minutoli, M.Morganti, P. Musico, M.Musumeci, C.A.Nicolau, A.Orlando, M.Osipenko, R.Papaleo, V.Pappalardo, P. Piattelli, D.Piombo, G.Raia, N.Randazzo, S.Reito, G.Ricco, G.Riccobene, M.Ripani, A. Rovelli, M.Ruppi, G.V.Russo, S.Russo, P.Sapienza, D.Sciliberto, M.Sedita, E.Shirokov, F. Simeone, V.Sipala, M.Spurio, L.Trasatti, S.Urso, M.Vecchi, P.Vicini, and R.Wischnewski

Subjects
Physics, astroparticles, UNDERWATER CHERENKOV, Underwater Cherenkov neutrino telescopes, Neutrino astronomy, Nuclear and High Energy Physics, Particle physics, photomultiplier, Test site, Solar neutrino, Detector, NEUTRINOTELESCOPES, Astronomy, neutrino telescope, Status report, uhe neutrinos, neutrino astronomy, underwater cherenkov neutrino telescopes, Neutrino detector, Instrumentation, Cherenkov radiation
Abstract

The latest results and the activities towards the construction of a km 3 Cherenkov neutrino detector carried out by the NEMO Collaboration are described. Long-term exploration of a 3500 m deep-sea site close to the Sicilian coast has shown that it is optimal for the installation of the detector. The NEMO Phase-1 project has validated several technologies proposed for the construction of the km 3 detector on a test site at 2000 m depth. The new infrastructure on the candidate Capo Passero site set up as part of the Phase-2 project will provide the possibility to test detector components at 3500 m depth.

Published
2011

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