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1. Botulism in cattle in Mato Grosso do Sul: History, current situation, and perspectives

Author: Stephanie C. Lima, Juliana P.L. Paula, Carolina C. Guizelini, Rayane C. Pupin, Larissa G. Avila, Danilo C. Gomes, Claudio S.L. Barros, and Ricardo A.A. Lemos
Subjects: Clostridial diseases, botulism, livestock, cattle, BoNTs, peripheral nervous system, Veterinary medicine, SF600-1100
Abstract: ABSTRACT: Botulism is a neuroparalytic disease caused by ingesting neurotoxins (BoNTs) produced by the anaerobic bacterium Clostridium botulinum. It is a significant cause of cattle mortality in Brazil. BoNTs block the release of acetylcholine at the neuromuscular synapses and cause muscle flaccidity. The diagnosis of botulism is challenging due to two main factors: the absence of macro and microscopic lesions and the difficulties inherent in laboratory tests considered the gold standard for botulism. Due to these difficulties, reviews of botulism diagnoses in Mato Grosso do Sul and extensively in the Center-West of Brazil became discrepant according to the diagnostic methodology used, making it difficult to correctly assess the disease’s prevalence, epidemiology, and clinical picture. This study aimed to review the diagnoses of botulism in cattle reported in Brazil, comparing the criteria used in each case. We studied the cause, the pathogenesis, clinical signs, and all the diagnosis methods applied to botulism. Based on the subject reviewed, we propose a diagnostic protocol based on standards adequate to the Brazilian circumstances. We also reviewed the critical diseases of cattle diseases to be included in the differential diagnosis of botulism.
Published: 2024
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2. Chamaecyparis lawsoniana and Its Active Compound Quercetin as Ca2+ Inhibitors in the Contraction of Airway Smooth Muscle

Author: Edgar Flores-Soto, Bianca S. Romero-Martínez, Héctor Solís-Chagoyán, Edgar A. Estrella-Parra, Jose G. Avila-Acevedo, Juan C. Gomez-Verjan, Jorge Reyes-García, María F. Casas-Hernández, Bettina Sommer, and Luis M. Montaño
Subjects: Chamaecyparis lawsoniana, quercetin, airway smooth muscle relaxation, store-operated Ca2+ channels, L-type voltage-dependent Ca2+ channels, Organic chemistry, QD241-441
Abstract: The Cupressaceae family includes species considered to be medicinal. Their essential oil is used for headaches, colds, cough, and bronchitis. Cedar trees like Chamaecyparis lawsoniana (C. lawsoniana) are commonly found in urban areas. We investigated whether C. lawsoniana exerts some of its effects by modifying airway smooth muscle (ASM) contractility. The leaves of C. lawsoniana (363 g) were pulverized mechanically, and extracts were obtained by successive maceration 1:10 (w:w) with methanol/CHCl3. Guinea pig tracheal rings were contracted with KCl, tetraethylammonium (TEA), histamine (HIS), or carbachol (Cch) in organ baths. In the Cch experiments, tissues were pre-incubated with D-600, an antagonist of L-type voltage-dependent Ca2+ channels (L-VDCC) before the addition of C. lawsoniana. Interestingly, at different concentrations, C. lawsoniana diminished the tracheal contractions induced by KCl, TEA, HIS, and Cch. In ASM cells, C. lawsoniana significantly diminished L-type Ca2+ currents. ASM cells stimulated with Cch produced a transient Ca2+ peak followed by a sustained plateau maintained by L-VDCC and store-operated Ca2+ channels (SOCC). C. lawsoniana almost abolished this last response. These results show that C. lawsoniana, and its active metabolite quercetin, relax the ASM by inhibiting the L-VDCC and SOCC; further studies must be performed to obtain the complete set of metabolites of the extract and study at length their pharmacological properties.
Published: 2024
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3. Water quality probe co-design for water monitoring in rural communities in Colombia.

Author: Darwin D. Rodriguez Pinto, Jaime Andres Perez-Taborda, Cesar G. Franco Rodriguez, Rodrigo Gomez Martinez, and Alba G. Avila Bernal
Published: 2022
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4. Large-scale Cosmic-ray Anisotropies with 19 yr of Data from the Pierre Auger Observatory

Author: A. Abdul Halim, P. Abreu, M. Aglietta, I. Allekotte, K. Almeida Cheminant, A. Almela, R. Aloisio, J. Alvarez-Muñiz, A. Ambrosone, J. Ammerman Yebra, G. A. Anastasi, L. Anchordoqui, B. Andrada, L. Andrade Dourado, S. Andringa, L. Apollonio, C. Aramo, P. R. Araújo Ferreira, E. Arnone, J. C. Arteaga Velázquez, P. Assis, G. Avila, E. Avocone, A. Bakalova, F. Barbato, A. Bartz Mocellin, J. A. Bellido, C. Berat, M. E. Bertaina, G. Bhatta, M. Bianciotto, P. L. Biermann, V. Binet, K. Bismark, T. Bister, J. Biteau, J. Blazek, C. Bleve, J. Blümer, M. Boháčová, D. Boncioli, C. Bonifazi, L. Bonneau Arbeletche, N. Borodai, J. Brack, P. G. Brichetto Orchera, F. L. Briechle, A. Bueno, S. Buitink, M. Buscemi, M. Büsken, A. Bwembya, K. S. Caballero-Mora, S. Cabana-Freire, L. Caccianiga, F. Campuzano, R. Caruso, A. Castellina, F. Catalani, G. Cataldi, L. Cazon, M. Cerda, B. Čermáková, A. Cermenati, J. A. Chinellato, J. Chudoba, L. Chytka, R. W. Clay, A. C. Cobos Cerutti, R. Colalillo, R. Conceição, A. Condorelli, G. Consolati, M. Conte, F. Convenga, D. Correia dos Santos, P. J. Costa, C. E. Covault, M. Cristinziani, C. S. Cruz Sanchez, S. Dasso, K. Daumiller, B. R. Dawson, R. M. de Almeida, B. de Errico, J. de Jesús, S. J. de Jong, J. R. T. de Mello Neto, I. De Mitri, J. de Oliveira, D. de Oliveira Franco, F. de Palma, V. de Souza, E. De Vito, A. Del Popolo, O. Deligny, N. Denner, L. Deval, A. di Matteo, C. Dobrigkeit, J. C. D’Olivo, L. M. Domingues Mendes, Q. Dorosti, J. C. dos Anjos, R. C. dos Anjos, J. Ebr, F. Ellwanger, M. Emam, R. Engel, I. Epicoco, M. Erdmann, A. Etchegoyen, C. Evoli, H. Falcke, G. Farrar, A. C. Fauth, T. Fehler, F. Feldbusch, A. Fernandes, B. Fick, J. M. Figueira, P. Filip, A. Filipčič, T. Fitoussi, B. Flaggs, T. Fodran, M. Freitas, T. Fujii, A. Fuster, C. Galea, B. García, C. Gaudu, P. L. Ghia, U. Giaccari, F. Gobbi, F. Gollan, G. Golup, M. Gómez Berisso, P. F. Gómez Vitale, J. P. Gongora, J. M. González, N. González, D. Góra, A. Gorgi, M. Gottowik, F. Guarino, G. P. Guedes, E. Guido, L. Gülzow, S. Hahn, P. Hamal, M. R. Hampel, P. Hansen, V. M. Harvey, A. Haungs, T. Hebbeker, C. Hojvat, J. R. Hörandel, P. Horvath, M. Hrabovský, T. Huege, A. Insolia, P. G. Isar, P. Janecek, V. Jilek, J. Jurysek, K.-H. Kampert, B. Keilhauer, A. Khakurdikar, V. V. Kizakke Covilakam, H. O. Klages, M. Kleifges, F. Knapp, J. Köhler, F. Krieger, M. Kubatova, N. Kunka, B. L. Lago, N. Langner, M. A. Leigui de Oliveira, Y. Lema-Capeans, A. Letessier-Selvon, I. Lhenry-Yvon, L. Lopes, J. P. Lundquist, A. Machado Payeras, D. Mandat, B. C. Manning, P. Mantsch, F. M. Mariani, A. G. Mariazzi, I. C. Mariş, G. Marsella, D. Martello, S. Martinelli, O. Martínez Bravo, M. A. Martins, H.-J. Mathes, J. Matthews, G. Matthiae, E. Mayotte, S. Mayotte, P. O. Mazur, G. Medina-Tanco, J. Meinert, D. Melo, A. Menshikov, C. Merx, S. Michal, M. I. Micheletti, L. Miramonti, S. Mollerach, F. Montanet, L. Morejon, K. Mulrey, R. Mussa, W. M. Namasaka, S. Negi, L. Nellen, K. Nguyen, G. Nicora, M. Niechciol, D. Nitz, D. Nosek, V. Novotny, L. Nožka, A. Nucita, L. A. Núñez, C. Oliveira, M. Palatka, J. Pallotta, S. Panja, G. Parente, T. Paulsen, J. Pawlowsky, M. Pech, J. Pȩkala, R. Pelayo, V. Pelgrims, L. A. S. Pereira, E. E. Pereira Martins, C. Pérez Bertolli, L. Perrone, S. Petrera, C. Petrucci, T. Pierog, M. Pimenta, M. Platino, B. Pont, M. Pothast, M. Pourmohammad Shahvar, P. Privitera, M. Prouza, S. Querchfeld, J. Rautenberg, D. Ravignani, J. V. Reginatto Akim, A. Reuzki, J. Ridky, F. Riehn, M. Risse, V. Rizi, E. Rodriguez, J. Rodriguez Rojo, M. J. Roncoroni, S. Rossoni, M. Roth, E. Roulet, A. C. Rovero, A. Saftoiu, M. Saharan, F. Salamida, H. Salazar, G. Salina, P. Sampathkumar, J. D. Sanabria Gomez, F. Sánchez, E. M. Santos, E. Santos, F. Sarazin, R. Sarmento, R. Sato, C. M. Schäfer, V. Scherini, H. Schieler, M. Schimassek, M. Schimp, D. Schmidt, O. Scholten, H. Schoorlemmer, P. Schovánek, F. G. Schröder, J. Schulte, T. Schulz, S. J. Sciutto, M. Scornavacche, A. Sedoski, A. Segreto, S. Sehgal, S. U. Shivashankara, G. Sigl, K. Simkova, F. Simon, R. Šmída, P. Sommers, R. Squartini, M. Stadelmaier, S. Stanič, J. Stasielak, P. Stassi, S. Strähnz, M. Straub, T. Suomijärvi, A. D. Supanitsky, Z. Svozilikova, Z. Szadkowski, F. Tairli, A. Tapia, C. Taricco, C. Timmermans, O. Tkachenko, P. Tobiska, C. J. Todero Peixoto, B. Tomé, Z. Torrès, A. Travaini, P. Travnicek, M. Tueros, M. Unger, R. Uzeiroska, L. Vaclavek, M. Vacula, J. F. Valdés Galicia, L. Valore, E. Varela, V. Vašíčková, A. Vásquez-Ramírez, D. Veberič, I. D. Vergara Quispe, V. Verzi, J. Vicha, J. Vink, S. Vorobiov, C. Watanabe, A. A. Watson, A. Weindl, M. Weitz, L. Wiencke, H. Wilczyński, D. Wittkowski, B. Wundheiler, B. Yue, A. Yushkov, O. Zapparrata, E. Zas, D. Zavrtanik, M. Zavrtanik, and The Pierre Auger Collaboration
Subjects: Ultra-high-energy cosmic radiation, Astrophysics, QB460-466
Abstract: Results are presented for the measurement of large-scale anisotropies in the arrival directions of ultra–high-energy cosmic rays detected at the Pierre Auger Observatory during 19 yr of operation, prior to AugerPrime, the upgrade of the observatory. The 3D dipole amplitude and direction are reconstructed above 4 EeV in four energy bins. Besides the established dipolar anisotropy in R.A. above 8 EeV, the Fourier amplitude of the 8–16 EeV energy bin is now also above the 5 σ discovery level. No time variation of the dipole moment above 8 EeV is found, setting an upper limit to the rate of change of such variations of 0.3% yr ^−1 at the 95% confidence level. Additionally, the results for the angular power spectrum are shown, demonstrating no other statistically significant multipoles. The results for the equatorial dipole component down to 0.03 EeV are presented, using for the first time a data set obtained with a trigger that has been optimized for lower energies. Finally, model predictions are discussed and compared with observations, based on two source emission scenarios obtained in the combined fit of spectrum and composition above 0.6 EeV.
Published: 2024
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5. The energy spectrum of cosmic rays beyond the turn-down around $$\varvec{10^{17}}$$ 10 17 eV as measured with the surface detector of the Pierre Auger Observatory

Author: P. Abreu, M. Aglietta, J. M. Albury, I. Allekotte, A. Almela, J. Alvarez-Muñiz, R. Alves Batista, G. A. Anastasi, L. Anchordoqui, B. Andrada, S. Andringa, C. Aramo, P. R. Araújo Ferreira, J. C. Arteaga Velázquez, H. Asorey, P. Assis, G. Avila, A. M. Badescu, A. Bakalova, A. Balaceanu, F. Barbato, R. J. Barreira Luz, K. H. Becker, J. A. Bellido, C. Berat, M. E. Bertaina, X. Bertou, P. L. Biermann, P. Billoir, V. Binet, K. Bismark, T. Bister, J. Biteau, J. Blazek, C. Bleve, M. Boháčová, D. Boncioli, C. Bonifazi, L. Bonneau Arbeletche, N. Borodai, A. M. Botti, J. Brack, T. Bretz, P. G. Brichetto Orchera, F. L. Briechle, P. Buchholz, A. Bueno, S. Buitink, M. Buscemi, M. Büsken, K. S. Caballero-Mora, L. Caccianiga, F. Canfora, I. Caracas, J. M. Carceller, R. Caruso, A. Castellina, F. Catalani, G. Cataldi, L. Cazon, M. Cerda, J. A. Chinellato, J. Chudoba, L. Chytka, R. W. Clay, A. C. Cobos Cerutti, R. Colalillo, A. Coleman, M. R. Coluccia, R. Conceição, A. Condorelli, G. Consolati, F. Contreras, F. Convenga, D. Correia dos Santos, C. E. Covault, S. Dasso, K. Daumiller, B. R. Dawson, J. A. Day, R. M. de Almeida, J. de Jesús, S. J. de Jong, G. De Mauro, J. R. T. de Mello Neto, I. De Mitri, J. de Oliveira, D. de Oliveira Franco, F. de Palma, V. de Souza, E. De Vito, M. del Río, O. Deligny, A. Di Matteo, C. Dobrigkeit, J. C. D’Olivo, L. M. Domingues Mendes, R. C. dos Anjos, D. dos Santos, M. T. Dova, J. Ebr, R. Engel, I. Epicoco, M. Erdmann, C. O. Escobar, A. Etchegoyen, H. Falcke, J. Farmer, G. Farrar, A. C. Fauth, N. Fazzini, F. Feldbusch, F. Fenu, B. Fick, J. M. Figueira, A. Filipčič, T. Fitoussi, T. Fodran, M. M. Freire, T. Fujii, A. Fuster, C. Galea, C. Galelli, B. García, A. L. Garcia Vegas, H. Gemmeke, F. Gesualdi, A. Gherghel-Lascu, P. L. Ghia, U. Giaccari, M. Giammarchi, J. Glombitza, F. Gobbi, F. Gollan, G. Golup, M. Gómez Berisso, P. F. Gómez Vitale, J. P. Gongora, J. M. González, N. González, I. Goos, D. Góra, A. Gorgi, M. Gottowik, T. D. Grubb, F. Guarino, G. P. Guedes, E. Guido, S. Hahn, P. Hamal, M. R. Hampel, P. Hansen, D. Harari, V. M. Harvey, A. Haungs, T. Hebbeker, D. Heck, G. C. Hill, C. Hojvat, J. R. Hörandel, P. Horvath, M. Hrabovský, T. Huege, A. Insolia, P. G. Isar, P. Janecek, J. A. Johnsen, J. Jurysek, A. Kääpä, K. H. Kampert, N. Karastathis, B. Keilhauer, J. Kemp, A. Khakurdikar, V. V. Kizakke Covilakam, H. O. Klages, M. Kleifges, J. Kleinfeller, M. Köpke, N. Kunka, B. L. Lago, R. G. Lang, N. Langner, M. A. Leigui de Oliveira, V. Lenok, A. Letessier-Selvon, I. Lhenry-Yvon, D. Lo Presti, L. Lopes, R. López, L. Lu, Q. Luce, J. P. Lundquist, A. Machado Payeras, G. Mancarella, D. Mandat, B. C. Manning, J. Manshanden, P. Mantsch, S. Marafico, A. G. Mariazzi, I. C. Mariş, G. Marsella, D. Martello, S. Martinelli, H. Martinez, O. Martínez Bravo, M. Mastrodicasa, H. J. Mathes, J. Matthews, G. Matthiae, E. Mayotte, P. O. Mazur, G. Medina-Tanco, D. Melo, A. Menshikov, K.-D. Merenda, S. Michal, M. I. Micheletti, L. Miramonti, D. Mockler, S. Mollerach, F. Montanet, C. Morello, M. Mostafá, A. L. Müller, M. A. Muller, K. Mulrey, R. Mussa, M. Muzio, W. M. Namasaka, A. Nasr-Esfahani, L. Nellen, M. Niculescu-Oglinzanu, M. Niechciol, D. Nitz, D. Nosek, V. Novotny, L. Nožka, A. Nucita, L. A. Núñez, M. Palatka, J. Pallotta, P. Papenbreer, G. Parente, A. Parra, J. Pawlowsky, M. Pech, F. Pedreira, J. Pȩkala, R. Pelayo, J. Peña-Rodriguez, E. E. Pereira Martins, J. Perez Armand, C. Pérez Bertolli, M. Perlin, L. Perrone, S. Petrera, T. Pierog, M. Pimenta, V. Pirronello, M. Platino, B. Pont, M. Pothast, P. Privitera, M. Prouza, A. Puyleart, S. Querchfeld, J. Rautenberg, D. Ravignani, M. Reininghaus, J. Ridky, F. Riehn, M. Risse, V. Rizi, W. Rodrigues de Carvalho, J. Rodriguez Rojo, M. J. Roncoroni, M. Roth, E. Roulet, A. C. Rovero, P. Ruehl, S. J. Saffi, A. Saftoiu, F. Salamida, H. Salazar, G. Salina, J. D. Sanabria Gomez, F. Sánchez, E. M. Santos, E. Santos, F. Sarazin, R. Sarmento, C. Sarmiento-Cano, R. Sato, P. Savina, C. M. Schäfer, V. Scherini, H. Schieler, M. Schimassek, M. Schimp, F. Schlüter, D. Schmidt, O. Scholten, P. Schovánek, F. G. Schröder, S. Schröder, J. Schulte, A. Schulz, S. J. Sciutto, M. Scornavacche, A. Segreto, S. Sehgal, R. C. Shellard, G. Sigl, G. Silli, O. Sima, R. Šmída, P. Sommers, J. F. Soriano, J. Souchard, R. Squartini, M. Stadelmaier, D. Stanca, S. Stanič, J. Stasielak, P. Stassi, A. Streich, M. Suárez-Durán, T. Sudholz, T. Suomijärvi, A. D. Supanitsky, Z. Szadkowski, A. Tapia, C. Taricco, C. Timmermans, O. Tkachenko, P. Tobiska, C. J. Todero Peixoto, B. Tomé, Z. Torrès, A. Travaini, P. Travnicek, C. Trimarelli, M. Tueros, R. Ulrich, M. Unger, L. Vaclavek, M. Vacula, J. F. Valdés Galicia, L. Valore, E. Varela, A. Vásquez-Ramírez, D. Veberič, C. Ventura, I. D. Vergara Quispe, V. Verzi, J. Vicha, J. Vink, S. Vorobiov, H. Wahlberg, C. Watanabe, A. A. Watson, M. Weber, A. Weindl, L. Wiencke, H. Wilczyński, M. Wirtz, D. Wittkowski, B. Wundheiler, A. Yushkov, O. Zapparrata, E. Zas, D. Zavrtanik, M. Zavrtanik, L. Zehrer, and Pierre Auger Collaboration
Subjects: Astrophysics, QB460-466, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract: Abstract We present a measurement of the cosmic-ray spectrum above 100 PeV using the part of the surface detector of the Pierre Auger Observatory that has a spacing of 750 m. An inflection of the spectrum is observed, confirming the presence of the so-called second-knee feature. The spectrum is then combined with that of the 1500 m array to produce a single measurement of the flux, linking this spectral feature with the three additional breaks at the highest energies. The combined spectrum, with an energy scale set calorimetrically via fluorescence telescopes and using a single detector type, results in the most statistically and systematically precise measurement of spectral breaks yet obtained. These measurements are critical for furthering our understanding of the highest energy cosmic rays.
Published: 2021
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6. Spatially resolved measurements of load current delivery on a 14 MA, 100 ns pulsed power experiment using a line-imaging velocity interferometer

Author: Clayton E. Myers, David E. Bliss, Peter M. Celliers, Philip S. Datte, Mark H. Hess, Christopher A. Jennings, Michael C. Jones, David J. Ampleford, Carlos R. Aragon, Kevin N. Austin, Thomas G. Avila, Thomas J. Awe, Jacob L. Baker, Ron Bettencourt, Erlan Bliss, Mark W. Bowers, Neil Butler, John R. Celeste, Todd J. Clancy, Simon J. Cohen, Levi J. Cortez, Michael K. Crosley, John Edwards, C. Leland Ellison, Jim Emig, David J. Erskine, William A. Farmer, Jeffrey R. Fein, Dayne E. Fratanduono, Gene Frieders, Justin D. Galbraith, Jeffrey K. Georgeson, Jeffry W. Gluth, Matthew R. Gomez, James H. Hammer, Roger L. Harmon, Jose Hernandez, John Jackson, Drew W. Johnson, Brent Jones, Patrick F. Knapp, Don Koen, Doug Larson, Keith R. LeChien, Michael C. Lowinske, Jeremy Lusk, Keven A. MacRunnels, Angel N. Martinez, Warren Massey, M. Keith Matzen, Andrew J. Maurer, Tom McCarville, Robert McDonald, Harry S. McLean, Jerry A. Mills, Leo P. Molina, Michael M. Montoya, Gregory Natoni, Matthew I. T. Olson, Andrew J. Porwitzky, Kumar S. Raman, Grafton K. Robertson, Gregory A. Rochau, Samuel Rodriguez, Rodney D. Scharberg, Daniel J. Scoglietti, Edward Scoglietti, Raymond Shelton, Jonathon E. Shores, Daniel B. Sinars, Christopher S. Speas, Robert J. Speas, Decker C. Spencer, Paul T. Springer, Eugene Vergel de Dios, Nathan R. Wemple, Scott E. Winters, J. Nan Wong, and Adam J. York
Subjects: Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract: Pulsed power generators create high-energy-density conditions by rapidly delivering an immense pulse of electrical current to a compact imploding load. Accurately measuring the shape and amplitude of this load current pulse is essential to understanding the behavior of all pulsed power experiments. At the Z Pulsed Power Facility, the closest-in load current measurements are provided by velocimetry techniques such as VISAR (velocity interferometer system for any reflector) and PDV (photonic Doppler velocimetry). Here, fiber-coupled interferometers measure the velocity history of an exploding metallic flyer plate that is embedded in the vertical walls of the current return can. The flyer plate is driven outward by the magnetic pressure from the load current such that magnetohydrodynamic modeling can be used to determine the load current waveform from the measured velocity history. In this paper, we present the first load current velocimetry measurements to be made from the horizontal top flyer plate that carries current radially inward from the return can to the load. These spatially resolved measurements, which span R=5–9 mm, are enabled by a transformative new velocimetry diagnostic—a line-imaging velocity interferometer called Z Line VISAR (ZLV)—whose optical performance overcomes the measurement challenges presented by the steep velocity gradients encountered on the top flyer plate. To validate ZLV’s capabilities, a 14-MA, 100-ns experiment was conducted to losslessly couple current up the return can and radially inward across the top flyer plate. Comparisons between the ZLV data obtained from this experiment and two-dimensional magnetohydrodynamic simulations driven with the current measured on the return can indicate that the current delivery across the top flyer plate is indeed lossless to within the few-percent uncertainty of the ZLV data. Given that the current coupling is lossless, the experimental results are used to demonstrate that one-dimensional current unfold techniques can be applied to generate a radially resolved load current map from the ZLV velocity data. This analysis provides a template for how to use the ZLV diagnostic to determine the efficacy of current delivery in future experiments where losses may occur in close proximity to the load.
Published: 2023
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7. Barreras de acceso y disponibilidad: servicio de laboratorios clínicos de emergencia, en hospitales públicos

Author: Ayari G. Avila-Larreal and Lisbeth C. Rangel-Matos
Subjects: accesibilidad a los servicios de salud, barreras de acceso a los servicios de salud, laboratorio clínico, hospitales, Medicine (General), R5-920, Public aspects of medicine, RA1-1270
Abstract: Objetivo. Describir las barreras de acceso y disponibilidad en laboratorios clínicos de emergencia en dos hospitales tipo IV con diferente localización geográfica en la Región Zuliana. Método. Estudio descriptivo y comparativo, con diseño no experimental transversal. Muestreo no probabilístico con tamaño muestral de 290 usuarios del servicio, 80 del Hospital 1 (H1) y 210 del Hospital 2 (H2). Los datos fueron obtenidos a través de encuesta mixta de elaboración propia, validada mediante concordancia entre expertos. Se utilizaron estadísticos descriptivos y comparación de medias, mediante la técnica T Student al 95% de confianza. Resultados. La principal barrera de acceso encontrada fue la geográfica, en el H1 (97,5 %) y el H2 (71,9 %). Se hallaron diferencias en la forma de traslado y tiempo requerido para llegar al centro de salud; en el H1 los pacientes utilizan sus vehículos (48,8 %) con tiempo de traslado 13,25±4,71 minutos; y en el H2 se utiliza principalmente transporte público (74,3 %) con tiempo de traslado mayor (50,09±34,4 min). La principal barrera administrativa fue la falta de insumos básicos (97,5% H1 vs 98,1% H2). Existen barreras económicas en ambos centros de salud: 53,8% en el H1 y 56,7% para el H2. Se evidenció mayor disponibilidad de pruebas en el laboratorio de emergencias del H1 (85,6 %) que en el H2 (31,72%). Conclusión. Existen barreras de acceso de tipo geográficas, administrativas, económicas y diferencias en la disponibilidad de insumos entre los laboratorios de los dos hospitales.
Published: 2022
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8. Direct measurement of the muonic content of extensive air showers between $$\mathbf { 2\times 10^{17}}$$ 2×1017 and $$\mathbf {2\times 10^{18}}~$$ 2×1018 eV at the Pierre Auger Observatory

Author: A. Aab, P. Abreu, M. Aglietta, J. M. Albury, I. Allekotte, A. Almela, J. Alvarez Castillo, J. Alvarez-Muñiz, G. A. Anastasi, L. Anchordoqui, B. Andrada, S. Andringa, C. Aramo, P. R. Araújo Ferreira, H. Asorey, P. Assis, G. Avila, A. M. Badescu, A. Bakalova, A. Balaceanu, F. Barbato, R. J. Barreira Luz, K. H. Becker, J. A. Bellido, C. Berat, M. E. Bertaina, X. Bertou, P. L. Biermann, T. Bister, J. Biteau, A. Blanco, J. Blazek, C. Bleve, M. Boháčová, D. Boncioli, C. Bonifazi, L. Bonneau Arbeletche, N. Borodai, A. M. Botti, J. Brack, T. Bretz, F. L. Briechle, P. Buchholz, A. Bueno, S. Buitink, M. Buscemi, K. S. Caballero-Mora, L. Caccianiga, L. Calcagni, A. Cancio, F. Canfora, I. Caracas, J. M. Carceller, R. Caruso, A. Castellina, F. Catalani, G. Cataldi, L. Cazon, M. Cerda, J. A. Chinellato, K. Choi, J. Chudoba, L. Chytka, R. W. Clay, A. C. Cobos Cerutti, R. Colalillo, A. Coleman, M. R. Coluccia, R. Conceição, A. Condorelli, G. Consolati, F. Contreras, F. Convenga, C. E. Covault, S. Dasso, K. Daumiller, B. R. Dawson, J. A. Day, R. M. de Almeida, J. de Jesús, S. J. de Jong, G. De Mauro, J. R. T. de Mello Neto, I. De Mitri, J. de Oliveira, D. de Oliveira Franco, V. de Souza, J. Debatin, M. del Río, O. Deligny, N. Dhital, A. Di Matteo, M. L. Díaz Castro, C. Dobrigkeit, J. C. D’Olivo, Q. Dorosti, R. C. dos Anjos, M. T. Dova, J. Ebr, R. Engel, I. Epicoco, M. Erdmann, C. O. Escobar, A. Etchegoyen, H. Falcke, J. Farmer, G. Farrar, A. C. Fauth, N. Fazzini, F. Feldbusch, F. Fenu, B. Fick, J. M. Figueira, A. Filipčič, M. M. Freire, T. Fujii, A. Fuster, C. Galea, C. Galelli, B. García, A. L. Garcia Vegas, H. Gemmeke, F. Gesualdi, A. Gherghel-Lascu, P. L. Ghia, U. Giaccari, M. Giammarchi, M. Giller, J. Glombitza, F. Gobbi, G. Golup, M. Gómez Berisso, P. F. Gómez Vitale, J. P. Gongora, N. González, I. Goos, D. Góra, A. Gorgi, M. Gottowik, T. D. Grubb, F. Guarino, G. P. Guedes, E. Guido, S. Hahn, R. Halliday, M. R. Hampel, P. Hansen, D. Harari, V. M. Harvey, A. Haungs, T. Hebbeker, D. Heck, G. C. Hill, C. Hojvat, J. R. Hörandel, P. Horvath, M. Hrabovský, T. Huege, J. Hulsman, A. Insolia, P. G. Isar, J. A. Johnsen, J. Jurysek, A. Kääpä, K. H. Kampert, B. Keilhauer, J. Kemp, H. O. Klages, M. Kleifges, J. Kleinfeller, M. Köpke, G. Kukec Mezek, B. L. Lago, D. LaHurd, R. G. Lang, M. A. Leigui de Oliveira, V. Lenok, A. Letessier-Selvon, I. Lhenry-Yvon, D. Lo Presti, L. Lopes, R. López, A. López Casado, R. Lorek, Q. Luce, A. Lucero, A. Machado Payeras, M. Malacari, G. Mancarella, D. Mandat, B. C. Manning, J. Manshanden, P. Mantsch, A. G. Mariazzi, I. C. Mariş, G. Marsella, D. Martello, H. Martinez, O. Martínez Bravo, M. Mastrodicasa, H. J. Mathes, J. Matthews, G. Matthiae, E. Mayotte, P. O. Mazur, G. Medina-Tanco, D. Melo, A. Menshikov, K.-D. Merenda, S. Michal, M. I. Micheletti, L. Miramonti, D. Mockler, S. Mollerach, F. Montanet, C. Morello, M. Mostafá, A. L. Müller, M. A. Muller, S. Müller, R. Mussa, M. Muzio, W. M. Namasaka, L. Nellen, M. Niculescu-Oglinzanu, M. Niechciol, D. Nitz, D. Nosek, V. Novotny, L. Nožka, A Nucita, L. A. Núñez, M. Palatka, J. Pallotta, M. P. Panetta, P. Papenbreer, G. Parente, A. Parra, M. Pech, F. Pedreira, J. Pȩkala, R. Pelayo, J. Peña-Rodriguez, J. Perez Armand, M. Perlin, L. Perrone, C. Peters, S. Petrera, T. Pierog, M. Pimenta, V. Pirronello, M. Platino, B. Pont, M. Pothast, P. Privitera, M. Prouza, A. Puyleart, S. Querchfeld, J. Rautenberg, D. Ravignani, M. Reininghaus, J. Ridky, F. Riehn, M. Risse, P. Ristori, V. Rizi, W. Rodrigues de Carvalho, J. Rodriguez Rojo, M. J. Roncoroni, M. Roth, E. Roulet, A. C. Rovero, P. Ruehl, S. J. Saffi, A. Saftoiu, F. Salamida, H. Salazar, G. Salina, J. D. Sanabria Gomez, F. Sánchez, E. M. Santos, E. Santos, F. Sarazin, R. Sarmento, C. Sarmiento-Cano, R. Sato, P. Savina, C. Schäfer, V. Scherini, H. Schieler, M. Schimassek, M. Schimp, F. Schlüter, D. Schmidt, O. Scholten, P. Schovánek, F. G. Schröder, S. Schröder, S. J. Sciutto, M. Scornavacche, R. C. Shellard, G. Sigl, G. Silli, O. Sima, R. Šmída, P. Sommers, J. F. Soriano, J. Souchard, R. Squartini, M. Stadelmaier, D. Stanca, S. Stanič, J. Stasielak, P. Stassi, A. Streich, M. Suárez-Durán, T. Sudholz, T. Suomijärvi, A. D. Supanitsky, J. Šupík, Z. Szadkowski, A. Taboada, O. A. Taborda, A. Tapia, C. Timmermans, P. Tobiska, C. J. Todero Peixoto, B. Tomé, G. Torralba Elipe, A. Travaini, P. Travnicek, C. Trimarelli, M. Trini, M. Tueros, R. Ulrich, M. Unger, M. Urban, L. Vaclavek, J. F. Valdés Galicia, I. Valiño, L. Valore, A. van Vliet, E. Varela, B. Vargas Cárdenas, A. Vásquez-Ramírez, D. Veberič, C. Ventura, I. D. Vergara Quispe, V. Verzi, J. Vicha, L. Villaseñor, J. Vink, S. Vorobiov, H. Wahlberg, A. A. Watson, M. Weber, A. Weindl, L. Wiencke, H. Wilczyński, T. Winchen, M. Wirtz, D. Wittkowski, B. Wundheiler, A. Yushkov, O. Zapparrata, E. Zas, D. Zavrtanik, M. Zavrtanik, L. Zehrer, A. Zepeda, M. Ziolkowski, F. Zuccarello, and The Pierre Auger Collaboration
Subjects: Astrophysics, QB460-466, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract: Abstract The hybrid design of the Pierre Auger Observatory allows for the measurement of the properties of extensive air showers initiated by ultra-high energy cosmic rays with unprecedented precision. By using an array of prototype underground muon detectors, we have performed the first direct measurement, by the Auger Collaboration, of the muon content of air showers between $$2\times 10^{17}$$ 2×1017 and $$2\times 10^{18}$$ 2×1018 eV. We have studied the energy evolution of the attenuation-corrected muon density, and compared it to predictions from air shower simulations. The observed densities are found to be larger than those predicted by models. We quantify this discrepancy by combining the measurements from the muon detector with those from the Auger fluorescence detector at $$10^{{17.5}}\, {\mathrm{eV}} $$ 1017.5eV and $$10^{{18}}\, {\mathrm{eV}} $$ 1018eV . We find that, for the models to explain the data, an increase in the muon density of $$38\%$$ 38% $$\pm 4\% (12\%)$$ ±4%(12%) $$\pm {}^{21\%}_{18\%}$$ ±18%21% for EPOS-LHC, and of $$50\% (53\%)$$ 50%(53%) $$\pm 4\% (13\%)$$ ±4%(13%) $$\pm {}^{23\%}_{20\%}$$ ±20%23% for QGSJetII-04, is respectively needed.
Published: 2020
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9. Precision non-implantable neuromodulation therapies: a perspective for the depressed brain

Author: Lucas Borrione, Helena Bellini, Lais Boralli Razza, Ana G. Avila, Chris Baeken, Anna-Katharine Brem, Geraldo Busatto, Andre F. Carvalho, Adam Chekroud, Zafiris J. Daskalakis, Zhi-De Deng, Jonathan Downar, Wagner Gattaz, Colleen Loo, Paulo A. Lotufo, Maria da Graça M. Martin, Shawn M. McClintock, Jacinta O’Shea, Frank Padberg, Ives C. Passos, Giovanni A. Salum, Marie-Anne Vanderhasselt, Renerio Fraguas, Isabela Benseñor, Leandro Valiengo, and Andre R. Brunoni
Subjects: Major depressive disorder, transcranial magnetic stimulation, transcranial direct current stimulation, electroconvulsive therapy, precision medicine, Psychiatry, RC435-571
Abstract: Current first-line treatments for major depressive disorder (MDD) include pharmacotherapy and cognitive-behavioral therapy. However, one-third of depressed patients do not achieve remission after multiple medication trials, and psychotherapy can be costly and time-consuming. Although non-implantable neuromodulation (NIN) techniques such as transcranial magnetic stimulation, transcranial direct current stimulation, electroconvulsive therapy, and magnetic seizure therapy are gaining momentum for treating MDD, the efficacy of non-convulsive techniques is still modest, whereas use of convulsive modalities is limited by their cognitive side effects. In this context, we propose that NIN techniques could benefit from a precision-oriented approach. In this review, we discuss the challenges and opportunities in implementing such a framework, focusing on enhancing NIN effects via a combination of individualized cognitive interventions, using closed-loop approaches, identifying multimodal biomarkers, using computer electric field modeling to guide targeting and quantify dosage, and using machine learning algorithms to integrate data collected at multiple biological levels and identify clinical responders. Though promising, this framework is currently limited, as previous studies have employed small samples and did not sufficiently explore pathophysiological mechanisms associated with NIN response and side effects. Moreover, cost-effectiveness analyses have not been performed. Nevertheless, further advancements in clinical trials of NIN could shift the field toward a more “precision-oriented” practice.
Published: 2020
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10. Hydroxytyrosol inhibits MAO isoforms and prevents neurotoxicity inducible by MPP+ in vivo

Author: Gabriela A. Perez-Barron, Sergio Montes, Moises Rubio-Osornio, Jose G. Avila-Acevedo, Sara Garcia-Jimenez, Luis C. Rios, and Antonio Monroy-Noyola
Subjects: hydroxytyrosol, mpp+, parkinson's disease, monoamine oxidase, neuroprotection, Biology (General), QH301-705.5, Biochemistry, QD415-436
Abstract: Parkinson’s disease is considered to be due to an increase in the catabolism of dopamine by the action of monoamine oxidase (MAO) enzymes which leads to an increase in reactive oxygen species (ROS) and loss of dopaminergic neurons. Here, in a model of neurotoxicity inducible by 1-methyl-4-phenylpyridinium (MPP+), we tested the effect of hydroxytyrosol (HTy), a potent antioxidant, on generation of ROS. Five minutes after a single intravenous administration of 1.5 mg/Kg of Hty, Wistar rats received an intrastriatal micro-injection of 10 micrograms of MPP+ while control animals received saline solution. Six days later, all animals were treated with apomorphine (1 mg/Kg), subcutaneously and ipsilateral rotations were assessed within an hour. Then, the rats were sacrificed, striatal tissues were removed and their catecholamines and MAO-A and B activities were quantitated. Pretreatment with HTy significantly diminished the number of ipsilateral rotations. This recovery correlated with significant preservation of striatal dopamine and significant inhibition of of the MAO activity. These results are consistent with the inhibitory effect of HTy on the MAO isoforms and form a basis for the neuroprotective mechanism of this phenylpropanoid in MPP+ induced Parkinson’s disease.
Published: 2020
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11. Search for Ultra-high-energy Photons from Gravitational Wave Sources with the Pierre Auger Observatory

Author: A. Abdul Halim, P. Abreu, M. Aglietta, I. Allekotte, K. Almeida Cheminant, A. Almela, J. Alvarez-Muñiz, J. Ammerman Yebra, G. A. Anastasi, L. Anchordoqui, B. Andrada, S. Andringa, C. Aramo, P. R. Araújo Ferreira, E. Arnone, J. C. Arteaga Velázquez, H. Asorey, P. Assis, G. Avila, E. Avocone, A. M. Badescu, A. Bakalova, A. Balaceanu, F. Barbato, J. A. Bellido, C. Berat, M. E. Bertaina, G. Bhatta, P. L. Biermann, V. Binet, K. Bismark, T. Bister, J. Biteau, J. Blazek, C. Bleve, J. Blümer, M. Boháčová, D. Boncioli, C. Bonifazi, L. Bonneau Arbeletche, N. Borodai, J. Brack, T. Bretz, P. G. Brichetto Orchera, F. L. Briechle, P. Buchholz, A. Bueno, S. Buitink, M. Buscemi, M. Büsken, A. Bwembya, K. S. Caballero-Mora, L. Caccianiga, I. Caracas, R. Caruso, A. Castellina, F. Catalani, G. Cataldi, L. Cazon, M. Cerda, J. A. Chinellato, J. Chudoba, L. Chytka, R. W. Clay, A. C. Cobos Cerutti, R. Colalillo, A. Coleman, M. R. Coluccia, R. Conceiçao, A. Condorelli, G. Consolati, M. Conte, F. Contreras, F. Convenga, D. Correia dos Santos, P. J. Costa, C. E. Covault, M. Cristinziani, C. S. Cruz Sanchez, S. Dasso, K. Daumiller, B. R. Dawson, R. M. de Almeida, J. de Jesús, S. J. de Jong, J. R. T. de Mello Neto, I. De Mitri, J. de Oliveira, D. de Oliveira Franco, F. de Palma, V. de Souza, E. De Vito, A. Del Popolo, O. Deligny, L. Deval, A. di Matteo, M. Dobre, C. Dobrigkeit, J. C. D’Olivo, L. M. Domingues Mendes, R. C. dos Anjos, J. Ebr, M. Emam, R. Engel, I. Epicoco, M. Erdmann, A. Etchegoyen, H. Falcke, J. Farmer, G. Farrar, A. C. Fauth, N. Fazzini, F. Feldbusch, F. Fenu, A. Fernandes, B. Fick, J. M. Figueira, A. Filipčič, T. Fitoussi, B. Flaggs, T. Fodran, T. Fujii, A. Fuster, C. Galea, C. Galelli, B. García, H. Gemmeke, F. Gesualdi, A. Gherghel-Lascu, P. L. Ghia, U. Giaccari, M. Giammarchi, J. Glombitza, F. Gobbi, F. Gollan, G. Golup, M. Gómez Berisso, P. F. Gómez Vitale, J. P. Gongora, J. M. González, N. González, I. Goos, D. Góra, A. Gorgi, M. Gottowik, T. D. Grubb, F. Guarino, G. P. Guedes, E. Guido, S. Hahn, P. Hamal, M. R. Hampel, P. Hansen, D. Harari, V. M. Harvey, A. Haungs, T. Hebbeker, D. Heck, C. Hojvat, J. R. Hörandel, P. Horvath, M. Hrabovský, T. Huege, A. Insolia, P. G. Isar, P. Janecek, J. A. Johnsen, J. Jurysek, A. Kääpä, K. H. Kampert, B. Keilhauer, A. Khakurdikar, V. V. Kizakke Covilakam, H. O. Klages, M. Kleifges, J. Kleinfeller, F. Knapp, N. Kunka, B. L. Lago, N. Langner, M. A. Leigui de Oliveira, V. Lenok, A. Letessier-Selvon, I. Lhenry-Yvon, D. Lo Presti, L. Lopes, R. López, L. Lu, Q. Luce, J. P. Lundquist, A. Machado Payeras, M. Majercakova, D. Mandat, B. C. Manning, J. Manshanden, P. Mantsch, S. Marafico, F. M. Mariani, A. G. Mariazzi, I. C. Mariş, G. Marsella, D. Martello, S. Martinelli, O. Martínez Bravo, M. A. Martins, M. Mastrodicasa, H. J. Mathes, J. Matthews, G. Matthiae, E. Mayotte, S. Mayotte, P. O. Mazur, G. Medina-Tanco, J. Meinert, D. Melo, A. Menshikov, S. Michal, M. I. Micheletti, L. Miramonti, S. Mollerach, F. Montanet, L. Morejon, C. Morello, A. L. Müller, K. Mulrey, R. Mussa, M. Muzio, W. M. Namasaka, A. Nasr-Esfahani, L. Nellen, G. Nicora, M. Niculescu-Oglinzanu, M. Niechciol, D. Nitz, I. Norwood, D. Nosek, V. Novotny, L. Nožka, A. Nucita, L. A. Núñez, C. Oliveira, M. Palatka, J. Pallotta, G. Parente, A. Parra, J. Pawlowsky, M. Pech, J. Pȩkala, R. Pelayo, L. A. S. Pereira, E. E. Pereira Martins, J. Perez Armand, C. Pérez Bertolli, L. Perrone, S. Petrera, C. Petrucci, T. Pierog, M. Pimenta, M. Platino, B. Pont, M. Pothast, M. Pourmohammad Shavar, P. Privitera, M. Prouza, A. Puyleart, S. Querchfeld, J. Rautenberg, D. Ravignani, M. Reininghaus, J. Ridky, F. Riehn, M. Risse, V. Rizi, W. Rodrigues de Carvalho, J. Rodriguez Rojo, M. J. Roncoroni, S. Rossoni, M. Roth, E. Roulet, A. C. Rovero, P. Ruehl, A. Saftoiu, M. Saharan, F. Salamida, H. Salazar, G. Salina, J. D. Sanabria Gomez, F. Sánchez, E. M. Santos, E. Santos, F. Sarazin, R. Sarmento, R. Sato, P. Savina, C. M. Schäfer, V. Scherini, H. Schieler, M. Schimassek, M. Schimp, F. Schlüter, D. Schmidt, O. Scholten, H. Schoorlemmer, P. Schovánek, F. G. Schröder, J. Schulte, T. Schulz, S. J. Sciutto, M. Scornavacche, A. Segreto, S. Sehgal, S. U. Shivashankara, G. Sigl, G. Silli, O. Sima, R. Smau, R. Šmída, P. Sommers, J. F. Soriano, R. Squartini, M. Stadelmaier, D. Stanca, S. Stanič, J. Stasielak, P. Stassi, M. Straub, A. Streich, M. Suárez-Durán, T. Suomijärvi, A. D. Supanitsky, Z. Szadkowski, A. Tapia, C. Taricco, C. Timmermans, O. Tkachenko, P. Tobiska, C. J. Todero Peixoto, B. Tomé, Z. Torrès, A. Travaini, P. Travnicek, C. Trimarelli, M. Tueros, R. Ulrich, M. Unger, L. Vaclavek, M. Vacula, J. F. Valdés Galicia, L. Valore, E. Varela, A. Vásquez-Ramírez, D. Veberič, C. Ventura, I. D. Vergara Quispe, V. Verzi, J. Vicha, J. Vink, S. Vorobiov, C. Watanabe, A. A. Watson, A. Weindl, L. Wiencke, H. Wilczyński, D. Wittkowski, B. Wundheiler, A. Yushkov, O. Zapparrata, E. Zas, D. Zavrtanik, M. Zavrtanik, and The Pierre Auger Collaboration
Subjects: Particle astrophysics, Ultra-high-energy cosmic radiation, Cosmic ray showers, Gravitational wave sources, Transient sources, Astrophysics, QB460-466
Abstract: A search for time-directional coincidences of ultra-high-energy (UHE) photons above 10 EeV with gravitational wave (GW) events from the LIGO/Virgo runs O1 to O3 is conducted with the Pierre Auger Observatory. Due to the distinctive properties of photon interactions and to the background expected from hadronic showers, a subset of the most interesting GW events is selected based on their localization quality and distance. Time periods of 1000 s around and 1 day after the GW events are analyzed. No coincidences are observed. Upper limits on the UHE photon fluence from a GW event are derived that are typically at ∼7 MeV cm ^−2 (time period 1000 s) and ∼35 MeV cm ^−2 (time period 1 day). Due to the proximity of the binary neutron star merger GW170817, the energy of the source transferred into UHE photons above 40 EeV is constrained to be less than 20% of its total GW energy. These are the first limits on UHE photons from GW sources.
Published: 2023
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12. A Catalog of the Highest-energy Cosmic Rays Recorded during Phase I of Operation of the Pierre Auger Observatory

Author: A. Abdul Halim, P. Abreu, M. Aglietta, I. Allekotte, P. Allison, K. Almeida Cheminant, A. Almela, J. Alvarez-Muñiz, J. Ammerman Yebra, G. A. Anastasi, L. Anchordoqui, B. Andrada, S. Andringa, C. Aramo, P. R. Araújo Ferreira, E. Arnone, J. C. Arteaga Velázquez, H. Asorey, P. Assis, M. Ave, G. Avila, E. Avocone, A. M. Badescu, A. Bakalova, A. Balaceanu, F. Barbato, J. Beatty, J. A. Bellido, C. Berat, M. E. Bertaina, X. Bertou, G. Bhatta, P. L. Biermann, P. Billoir, V. Binet, K. Bismark, T. Bister, J. Biteau, J. Blazek, C. Bleve, J. Blümer, M. Boháčová, D. Boncioli, C. Bonifazi, L. Bonneau Arbeletche, N. Borodai, J. Brack, T. Bretz, P. G. Brichetto Orchera, F. L. Briechle, P. Buchholz, A. Bueno, S. Buitink, M. Buscemi, M. Büsken, A. Bwembya, K. S. Caballero-Mora, L. Caccianiga, I. Caracas, R. Caruso, A. Castellina, F. Catalani, G. Cataldi, L. Cazon, M. Cerda, R. Cester, J. A. Chinellato, J. Chirinos, J. Chudoba, L. Chytka, R. W. Clay, A. C. Cobos Cerutti, R. Colalillo, A. Coleman, M. R. Coluccia, R. Conceição, A. Condorelli, G. Consolati, F. Contreras, F. Convenga, D. Correia dos Santos, C. E. Covault, M. Cristinziani, C. S. Cruz Sanchez, S. Dasso, K. Daumiller, B. R. Dawson, R. M. de Almeida, J. de Jesús, S. J. de Jong, J. R. T. de Mello Neto, I. De Mitri, J. de Oliveira, D. de Oliveira Franco, F. de Palma, V. de Souza, E. De Vito, A. Del Popolo, O. Deligny, L. Deval, A. di Matteo, M. Dobre, C. Dobrigkeit, J. C. D’Olivo, L. M. Domingues Mendes, A. Dorofeev, R. C. dos Anjos, J. Ebr, M. Eman, R. Engel, I. Epicoco, M. Erdmann, A. Etchegoyen, H. Falcke, J. Farmer, G. Farrar, A. C. Fauth, N. Fazzini, F. Feldbusch, F. Fenu, B. Fick, J. M. Figueira, A. Filipčič, T. Fitoussi, B. Flaggs, T. Fodran, T. Fujii, A. Fuster, C. Galea, C. Galelli, B. García, H. Gemmeke, F. Gesualdi, A. Gherghel-Lascu, P. L. Ghia, U. Giaccari, M. Giammarchi, J. Glombitza, F. Gobbi, F. Gollan, G. Golup, M. Gómez Berisso, P. F. Gómez Vitale, J. P. Gongora, J. M. González, N. González, I. Goos, D. Góra, A. Gorgi, M. Gottowik, T. D. Grubb, F. Guarino, G. P. Guedes, E. Guido, S. Hahn, P. Hamal, M. R. Hampel, P. Hansen, D. Harari, J. Harton, V. M. Harvey, A. Haungs, T. Hebbeker, D. Heck, C. Hojvat, J. R. Hörandel, P. Horvath, M. Hrabovský, T. Huege, A. Insolia, P. G. Isar, P. Janecek, J. A. Johnsen, J. Jurysek, A. Kääpä, K. H. Kampert, B. Keilhauer, A. Khakurdikar, V. V. Kizakke Covilakam, H. O. Klages, M. Kleifges, J. Kleinfeller, F. Knapp, J. Knapp, N. Kunka, C. Lachaud, B. L. Lago, N. Langner, M. A. Leigui de Oliveira, V. Lenok, A. Letessier-Selvon, I. Lhenry-Yvon, D. Lo Presti, L. Lopes, R. López, L. Lu, Q. Luce, J. P. Lundquist, A. Machado Payeras, D. Mandat, B. C. Manning, J. Manshanden, P. Mantsch, S. Marafico, F. M. Mariani, A. G. Mariazzi, I. C. Mariş, G. Marsella, D. Martello, S. Martinelli, O. Martínez Bravo, M. A. Martins, M. Mastrodicasa, H. J. Mathes, J. Matthews, G. Matthiae, E. Mayotte, S. Mayotte, P. O. Mazur, G. Medina-Tanco, J. Meinert, D. Melo, A. Menshikov, S. Michal, M. I. Micheletti, L. Miramonti, S. Mollerach, F. Montanet, L. Morejon, C. Morello, A. L. Müller, K. Mulrey, R. Mussa, M. Muzio, W. M. Namasaka, A. Nasr-Esfahani, L. Nellen, G. Nicora, M. Niculescu-Oglinzanu, M. Niechciol, D. Nitz, I. Norwood, D. Nosek, V. Novotny, L. Nožka, A Nucita, L. A. Núñez, C. Oliveira, M. Palatka, J. Pallotta, G. Parente, A. Parra, J. Pawlowsky, M. Pech, J. Pȩkala, R. Pelayo, E. E. Pereira Martins, J. Perez Armand, C. Pérez Bertolli, L. Perrone, S. Petrera, C. Petrucci, T. Pierog, M. Pimenta, M. Platino, B. Pont, M. Pothast, M. Pourmohammad Shavar, P. Privitera, M. Prouza, A. Puyleart, S. Querchfeld, J. Rautenberg, D. Ravignani, M. Reininghaus, J. Ridky, F. Riehn, M. Risse, V. Rizi, W. Rodrigues de Carvalho, J. Rodriguez Rojo, M. J. Roncoroni, S. Rossoni, M. Roth, E. Roulet, A. C. Rovero, P. Ruehl, A. Saftoiu, M. Saharan, F. Salamida, H. Salazar, G. Salina, J. D. Sanabria Gomez, F. Sánchez, E. M. Santos, E. Santos, F. Sarazin, R. Sarmento, R. Sato, P. Savina, C. M. Schäfer, V. Scherini, H. Schieler, M. Schimassek, M. Schimp, F. Schlüter, D. Schmidt, O. Scholten, H. Schoorlemmer, P. Schovánek, F. G. Schröder, J. Schulte, T. Schulz, S. J. Sciutto, M. Scornavacche, A. Segreto, S. Sehgal, S. U. Shivashankara, G. Sigl, G. Silli, O. Sima, R. Smau, R. Šmída, P. Sommers, J. F. Soriano, R. Squartini, M. Stadelmaier, D. Stanca, S. Stanič, J. Stasielak, P. Stassi, M. Straub, A. Streich, M. Suárez-Durán, T. Sudholz, T. Suomijärvi, A. D. Supanitsky, Z. Szadkowski, A. Tapia, C. Taricco, C. Timmermans, O. Tkachenko, P. Tobiska, C. J. Todero Peixoto, B. Tomé, Z. Torrès, A. Travaini, P. Travnicek, C. Trimarelli, M. Tueros, R. Ulrich, M. Unger, L. Vaclavek, M. Vacula, J. F. Valdés Galicia, L. Valore, E. Varela, A. Vásquez-Ramírez, D. Veberič, C. Ventura, I. D. Vergara Quispe, V. Verzi, J. Vicha, L. M. Villase nor Cendejas, J. Vink, S. Vorobiov, C. Watanabe, A. A. Watson, A. Weindl, L. Wiencke, H. Wilczyński, D. Wittkowski, B. Wundheiler, P. Younk, A. Yushkov, O. Zapparrata, E. Zas, D. Zavrtanik, M. Zavrtanik, and (The Pierre Auger Collaboration)
Subjects: Ultra-high-energy cosmic radiation, Cosmic ray showers, Experimental data, Catalogs, Astrophysics, QB460-466
Abstract: A catalog containing details of the highest-energy cosmic rays recorded through the detection of extensive air showers at the Pierre Auger Observatory is presented with the aim of opening the data to detailed examination. Descriptions of the 100 showers created by the highest-energy particles recorded between 2004 January 1 and 2020 December 31 are given for cosmic rays that have energies in the range 78–166 EeV. Details are also given on a further nine very energetic events that have been used in the calibration procedure adopted to determine the energy of each primary. A sky plot of the arrival directions of the most energetic particles is shown. No interpretations of the data are offered.
Published: 2023
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13. PB1769: REAL WORLD DATA OUTCOMES IN A SINGLE MEXICAN PUBLIC INSTITUTION. ADOLESCENTS AND YOUNG ADULTS (AYAS) WITH NEWLY DIAGNOSED OF ACUTE LYMPHOBLASTIC LEUKEMIA:COMPARATIVE RESULTS OF DIFFERENT PROTOCOLS

Author: G. Sotomayor Duque, W. Nava Gutiérrez, S. Baltazar Arellano, M. L. Guajardo Leal, D. G. Cruz Contreras, J. L. Cedillo de la Cerda, H. P. Sorkee Davila, J. A. Carrizales Villarreal, M. P. Pequeño Luevano, I. Borjon Cabada, C. Quirino Marquez, A. Mecott Estudillo, G. Avila Contreras, D. C. Aldama Gutiérrez, D. Garza Escobar, Y. Garcia Cerda, V. Valerio Bugarin, K. Machuca Adame, L. O. Gudiño Cobos, R. Saldaña Vazquez, R. E. De León Cantu, and R. Hernadez Valdez
Subjects: Diseases of the blood and blood-forming organs, RC633-647.5
Published: 2022
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14. PB1994: REAL WORLD DATA OF PATIENTS WITH MULTIPLE MYELOMA WITHOUT ACCESS A NOVEL AGENT IN FIRST LINE THERAPY IN PUBLIC HEALTH HOSPITAL IN MEXICO

Author: D. Cruz, G. SOTOMAYOR, and L. G. AVILA
Subjects: Diseases of the blood and blood-forming organs, RC633-647.5
Published: 2022
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15. Coatings and Thin-Film Technologies

Author: Jaime Andres Perez-Taborda, Alba G. Avila Bernal
Published: 2019

16. Exploring the potential of Fabiana imbricata Ruiz et Pav. ('Pichi') against pest insects and pathogenic microorganisms for crop protection

Author: Fabiana L. Silva, Soledad Quiroz-Carreño, Marcelo J.P. Ferreira, Zhao-Jun Wei, Kiran Thakur, Xingang Lv, Jose G. Avila-Acevedo, Isao Kubo, David S. Seigler, Gokhan Zengin, Kouadio Ibrahime Sinan, Adriano Mollica, Julio Alarcón-Enos, Edgar Pastene-Navarrete, and Carlos L. Céspedes-Acuña
Subjects: INSETICIDAS, Plant Science
Published: 2022

17. A 3‐Year Sample of Almost 1,600 Elves Recorded Above South America by the Pierre Auger Cosmic‐Ray Observatory

Author: A. Aab, P. Abreu, M. Aglietta, I. F. M. Albuquerque, J. M. Albury, I. Allekotte, A. Almela, J. Alvarez Castillo, J. Alvarez‐Muñiz, G. A. Anastasi, L. Anchordoqui, B. Andrada, S. Andringa, C. Aramo, H. Asorey, P. Assis, G. Avila, A. M. Badescu, A. Bakalova, A. Balaceanu, F. Barbato, R. J. Barreira Luz, S. Baur, K. H. Becker, J.A. Bellido, C. Berat, M. E. Bertaina, X. Bertou, P. L. Biermann, J. Biteau, S. G. Blaess, A. Blanco, J. Blazek, C. Bleve, M. Boháčová, D. Boncioli, C. Bonifazi, N. Borodai, A. M. Botti, J. Brack, T. Bretz, A. Bridgeman, F. L. Briechle, P. Buchholz, A. Bueno, S. Buitink, M. Buscemi, K. S. Caballero‐Mora, L. Caccianiga, L. Calcagni, A. Cancio, F. Canfora, J. M. Carceller, R. Caruso, A. Castellina, F. Catalani, G. Cataldi, L. Cazon, M. Cerda, J. A. Chinellato, J. Chudoba, L. Chytka, R.W. Clay, A. C. Cobos Cerutti, R. Colalillo, A. Coleman, M. R. Coluccia, R. Conceição, A. Condorelli, G. Consolati, F. Contreras, M. J. Cooper, S. Coutu, C. E. Covault, B. Daniel, S. Dasso, K. Daumiller, B. R. Dawson, J. A. Day, R. M. deAlmeida, S. J. deJong, G. Mauro, J. R. T. deMello Neto, I. Mitri, J. deOliveira, F. O. deOliveira Salles, V. deSouza, J. Debatin, M. delRío, O. Deligny, N. Dhital, M. L. Díaz Castro, F. Diogo, C. Dobrigkeit, J. C. D'Olivo, Q. Dorosti, R. C. dosAnjos, M. T. Dova, A. Dundovic, J. Ebr, R. Engel, M. Erdmann, C. O. Escobar, A. Etchegoyen, H. Falcke, J. Farmer, G. Farrar, A. C. Fauth, N. Fazzini, F. Feldbusch, F. Fenu, L. P. Ferreyro, J. M. Figueira, A. Filipčič, M. M. Freire, T. Fujii, A. Fuster, B. García, H. Gemmeke, A. Gherghel‐Lascu, P. L. Ghia, U. Giaccari, M. Giammarchi, M. Giller, D. Głas, J. Glombitza, F. Gobbi, G. Golup, M. Gómez Berisso, P. F. Gómez Vitale, J. P. Gongora, N. González, I. Goos, D. Góra, A. Gorgi, M. Gottowik, T. D. Grubb, F. Guarino, G. P. Guedes, E. Guido, R. Halliday, M. R. Hampel, P. Hansen, D. Harari, T. A. Harrison, V. M. Harvey, A. Haungs, T. Hebbeker, D. Heck, P. Heimann, G. C. Hill, C. Hojvat, E. M. Holt, P. Homola, J. R. Hörandel, P. Horvath, M. Hrabovský, T. Huege, J. Hulsman, A. Insolia, P. G. Isar, I. Jandt, J. A. Johnsen, M. Josebachuili, J. Jurysek, A. Kääpä, K. H. Kampert, B. Keilhauer, N. Kemmerich, J. Kemp, H. O. Klages, M. Kleifges, J. Kleinfeller, R. Krause, D. Kuempel, G. Kukec Mezek, A. Kuotb Awad, B. L. Lago, D. LaHurd, R. G. Lang, R. Legumina, M. A. Leigui de Oliveira, V. Lenok, A. Letessier‐Selvon, I. Lhenry‐Yvon, O. C. Lippmann, D. Lo Presti, L. Lopes, R. López, A. López Casado, R. Lorek, Q. Luce, A. Lucero, M. Malacari, G. Mancarella, D. Mandat, B. C. Manning, P. Mantsch, A. G. Mariazzi, I. C. Mariş, G. Marsella, D. Martello, H. Martinez, O. Martínez Bravo, M. Mastrodicasa, H. J. Mathes, S. Mathys, J. Matthews, G. Matthiae, E. Mayotte, P. O. Mazur, G. Medina‐Tanco, D. Melo, A. Menshikov, K.‐D. Merenda, S. Michal, M. I. Micheletti, L. Middendorf, L. Miramonti, B. Mitrica, D. Mockler, S. Mollerach, F. Montanet, C. Morello, G. Morlino, M. Mostafá, A. L. Müller, M. A. Muller, S. Müller, R. Mussa, L. Nellen, P. H. Nguyen, M. Niculescu‐Oglinzanu, M. Niechciol, D. Nitz, D. Nosek, V. Novotny, L. Noža, A Nucita, L.A. Núñez, A. Olinto, M. Palatka, J. Pallotta, M. P. Panetta, P. Papenbreer, G. Parente, A. Parra, M. Pech, F. Pedreira, J. Pękala, R. Pelayo, J. Peña‐Rodriguez, L. A. S. Pereira, M. Perlin, L. Perrone, C. Peters, S. Petrera, J. Phuntsok, T. Pierog, M. Pimenta, V. Pirronello, M. Platino, J. Poh, B. Pont, C. Porowski, R. R. Prado, P. Privitera, M. Prouza, A. Puyleart, S. Querchfeld, S. Quinn, R. Ramos‐Pollan, J. Rautenberg, D. Ravignani, M. Reininghaus, J. Ridky, F. Riehn, M. Risse, P. Ristori, V. Rizi, W. Rodrigues de Carvalho, J. Rodriguez Rojo, M. J. Roncoroni, M. Roth, E. Roulet, A. C. Rovero, P. Ruehl, S. J. Saffi, A. Saftoiu, F. Salamida, H. Salazar, G. Salina, J. D. Sanabria Gomez, F. Sánchez, E. M. Santos, E. Santos, F. Sarazin, R. Sarmento, C. Sarmiento‐Cano, R. Sato, P. Savina, M. Schauer, V. Scherini, H. Schieler, M. Schimassek, M. Schimp, F. Schlüter, D. Schmidt, O. Scholten, P. Schovánek, F. G. Schröder, S. Schröder, J. Schumacher, S. J. Sciutto, M. Scornavacche, R. C. Shellard, G. Sigl, G. Silli, O. Sima, R. Šmída, G.R. Snow, P. Sommers, J. F. Soriano, J. Souchard, R. Squartini, D. Stanca, S. Stanič, J. Stasielak, P. Stassi, M. Stolpovskiy, A. Streich, F. Suarez, M. Suárez‐Durán, T. Sudholz, T. Suomijärvi, A.D. Supanitsky, J. Šupík, Z. Szadkowski, A. Taboada, O. A. Taborda, A. Tapia, C. Timmermans, C. J. Todero Peixoto, B. Tomé, G. Torralba Elipe, A. Travaini, P. Travnicek, M. Trini, M. Tueros, R. Ulrich, M. Unger, M. Urban, J. F. Valdés Galicia, I. Valiño, L. Valore, P. vanBodegom, A. M. van denBerg, A. vanVliet, E. Varela, B. Vargas Cárdenas, D. Veberič, C. Ventura, I. D. Vergara Quispe, V. Verzi, J. Vicha, L. Villaseñor, J. Vink, S. Vorobiov, H. Wahlberg, A. A. Watson, M. Weber, A. Weindl, M. Wiedeński, L. Wiencke, H. Wilczyński, T. Winchen, M. Wirtz, D. Wittkowski, B. Wundheiler, L. Yang, A. Yushkov, E. Zas, D. Zavrtanik, M. Zavrtanik, L. Zehrer, A. Zepeda, B. Zimmermann, M. Ziolkowski, Z. Zong, and F. Zuccarello
Subjects: Astronomy, QB1-991, Geology, QE1-996.5
Abstract: Abstract Elves are a class of transient luminous events, with a radial extent typically greater than 250 km, that occur in the lower ionosphere above strong electrical storms. We report the observation of 1,598 elves, from 2014 to 2016, recorded with unprecedented time resolution (100 ns) using the fluorescence detector (FD) of the Pierre Auger Cosmic‐Ray Observatory. The Auger Observatory is located in the Mendoza province of Argentina with a viewing footprint for elve observations of 3·106 km 2, reaching areas above the Pacific and Atlantic Oceans, as well as the Córdoba region, which is known for severe convective thunderstorms. Primarily designed for ultrahigh energy cosmic‐ray observations, the Auger FD turns out to be very sensitive to the ultraviolet emission in elves. The detector features modified Schmidt optics with large apertures resulting in a field of view that spans the horizon, and year‐round operation on dark nights with low moonlight background, when the local weather is favorable. The measured light profiles of 18% of the elve events have more than one peak, compatible with intracloud activity. Within the 3‐year sample, 72% of the elves correlate with the far‐field radiation measurements of the World Wide Lightning Location Network. The Auger Observatory plans to continue operations until at least 2025, including elve observations and analysis. To the best of our knowledge, this observatory is the only facility on Earth that measures elves with year‐round operation and full horizon coverage.
Published: 2020
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18. MicroRNA-204/CREB5 axis regulates vasculogenic mimicry in breast cancer cells

Author: Estefania Contreras-Sanzón, Carlos Palma-Flores, Ali Flores-Pérez, Yarely M. Salinas-Vera, Macrina B. Silva-Cázares, Laurence A. Marchat, Rodolfo G. Avila-Bonilla, Olga N. Hernández de la Cruz, María E. Álvarez-Sánchez, Carlos Pérez-Plasencia, Alma D. Campos-Parra, and César López-Camarillo
Subjects: Cancer Research, Neovascularization, Pathologic, Breast Neoplasms, General Medicine, Cyclic AMP Response Element-Binding Protein A, Gene Expression Regulation, Neoplastic, MicroRNAs, Oncology, Cell Line, Tumor, Tumor Microenvironment, Genetics, Humans, Female, Hypoxia, 3' Untranslated Regions, Transcription Factors
Abstract: BACKGROUND: Vasculogenic mimicry (VM) is characterized by formation of three-dimensional (3D) channels-like structures by tumor cells, supplying the nutrients needed for tumor growth. VM is stimulated by hypoxic tumor microenvironment, and it has been associated with increased metastasis and clinical poor outcome in cancer patients. cAMP responsive element (CRE)-binding protein 5 (CREB5) is a hypoxia-activated transcription factor involved in tumorigenesis. However, CREB5 functions in VM and if its regulated by microRNAs remains unknown in breast cancer. OBJECTIVE: We aim to study the functional relationships between VM, CREB5 and microRNA-204-5p (miR-204) in breast cancer cells. METHODS: CREB5 expression was evaluated by mining the public databases, and using RT-qPCR and Western blot assays. CREB5 expression was silenced using short-hairpin RNAs in MDA-MB-231 and MCF-7 breast cancer cells. VM formation was analyzed using matrigel-based cultures in hypoxic conditions. MiR-204 expression was restored in cancer cells by transfection of RNA mimics. Luciferase reporter assays were performed to evaluate the binding of miR-204 to 3′UTR of CREB5. RESULTS: Our data showed that CREB5 mRNA expression was upregulated in a set of breast cancer cell lines and clinical tumors, and it was positively associated with poor prognosis in lymph nodes positive and grade 3 basal breast cancer patients. Silencing of CREB5 impaired the hypoxia-induced formation of 3D channels-like structures representative of the early stages of VM in MDA-MB-231 cells. In contrast, VM formation was not observed in MCF-7 cells. Interestingly, we found that CREB5 expression was negatively regulated by miR-204 mimics in breast cancer cells. Functional analysis confirmed that miR-204 binds to CREB5 3′-UTR indicating that it’s an ulterior effector. CONCLUSIONS: Our findings suggested that CREB5 could be a potential biomarker of disease progression in basal subtype of breast cancer, and that perturbations of the miR-204/CREB5 axis plays an important role in VM development in breast cancer cells.
Published: 2022

19. Multi-Messenger Physics With the Pierre Auger Observatory

Author: Karl-Heinz Kampert, Miguel Alejandro Mostafa, Enrique Zas, The Pierre Auger Collaboration, A. Aab, P. Abreu, M. Aglietta, I.F.M. Albuquerque, J.M. Albury, I. Allekotte, A. Almela, J. Alvarez Castillo, J. Alvarez-Muñiz, G.A. Anastasi, L. Anchordoqui, B. Andrada, S. Andringa, C. Aramo, H. Asorey, P. Assis, G. Avila, A.M. Badescu, A. Bakalova, A. Balaceanu, F. Barbato, R.J. Barreira Luz, S. Baur, K.H. Becker, J.A. Bellido, C. Berat, M.E. Bertaina, X. Bertou, P.L. Biermann, J. Biteau, S.G. Blaess, A. Blanco, J. Blazek, C. Bleve, M. Boháčová, D. Boncioli, C. Bonifazi, N. Borodai, A.M. Botti, J. Brack, T. Bretz, A. Bridgeman, F.L. Briechle, P. Buchholz, A. Bueno, S. Buitink, M. Buscemi, K.S. Caballero-Mora, L. Caccianiga, L. Calcagni, A. Cancio, F. Canfora, J.M. Carceller, R. Caruso, A. Castellina, F. Catalani, G. Cataldi, L. Cazon, M. Cerda, J.A. Chinellato, J. Chudoba, L. Chytka, R.W. Clay, A.C. Cobos Cerutti, R. Colalillo, A. Coleman, M.R. Coluccia, R. Conceição, A. Condorelli, G. Consolati, F. Contreras, F. Convenga, M.J. Cooper, S. Coutu, C.E. Covault, B. Daniel, S. Dasso, K. Daumiller, B.R. Dawson, J.A. Day, R.M. de Almeida, S.J. de Jong, G. De Mauro, J.R.T. de Mello Neto, I. De Mitri, J. de Oliveira, F.O. de Oliveira Salles, V. de Souza, J. Debatin, M. del Río, O. Deligny, N. Dhital, M.L. Díaz Castro, F. Diogo, C. Dobrigkeit, J.C. D'Olivo, Q. Dorosti, R.C. dos Anjos, M.T. Dova, A. Dundovic, J. Ebr, R. Engel, M. Erdmann, C.O. Escobar, A. Etchegoyen, H. Falcke, J. Farmer, G. Farrar, A.C. Fauth, N. Fazzini, F. Feldbusch, F. Fenu, L.P. Ferreyro, J.M. Figueira, A. Filipčič, M.M. Freire, T. Fujii, A. Fuster, B. García, H. Gemmeke, A. Gherghel-Lascu, P.L. Ghia, U. Giaccari, M. Giammarchi, M. Giller, D. Głas, J. Glombitza, F. Gobbi, G. Golup, M. Gómez Berisso, P.F. Gómez Vitale, J.P. Gongora, N. González, I. Goos, D. Góra, A. Gorgi, M. Gottowik, T.D. Grubb, F. Guarino, G.P. Guedes, E. Guido, R. Halliday, M.R. Hampel, P. Hansen, D. Harari, T.A. Harrison, V.M. Harvey, A. Haungs, T. Hebbeker, D. Heck, P. Heimann, G.C. Hill, C. Hojvat, E.M. Holt, P. Homola, J.R. Hörandel, P. Horvath, M. Hrabovský, T. Huege, J. Hulsman, A. Insolia, P.G. Isar, I. Jandt, J.A. Johnsen, M. Josebachuili, J. Jurysek, A. Kääpä, K.H. Kampert, B. Keilhauer, N. Kemmerich, J. Kemp, H.O. Klages, M. Kleifges, J. Kleinfeller, R. Krause, D. Kuempel, G. Kukec Mezek, A. Kuotb Awad, B.L. Lago, D. LaHurd, R.G. Lang, R. Legumina, M.A. Leigui de Oliveira, V. Lenok, A. Letessier-Selvon, I. Lhenry-Yvon, O.C. Lippmann, D. Lo Presti, L. Lopes, R. López, A. López Casado, R. Lorek, Q. Luce, A. Lucero, M. Malacari, G. Mancarella, D. Mandat, B.C. Manning, P. Mantsch, A.G. Mariazzi, I.C. Mariş, G. Marsella, D. Martello, H. Martinez, O. Martínez Bravo, M. Mastrodicasa, H.J. Mathes, S. Mathys, J. Matthews, G. Matthiae, E. Mayotte, P.O. Mazur, G. Medina-Tanco, D. Melo, A. Menshikov, K.-D. Merenda, S. Michal, M.I. Micheletti, L. Middendorf, L. Miramonti, B. Mitrica, D. Mockler, S. Mollerach, F. Montanet, C. Morello, G. Morlino, M. Mostafá, A.L. Müller, M.A. Muller, S. Müller, R. Mussa, L. Nellen, P.H. Nguyen, M. Niculescu-Oglinzanu, M. Niechciol, D. Nitz, D. Nosek, V. Novotny, L. Nožka, A Nucita, L.A. Núñez, F. Oikonomou, A. Olinto, M. Palatka, J. Pallotta, M.P. Panetta, P. Papenbreer, G. Parente, A. Parra, M. Pech, F. Pedreira, J. Pȩkala, R. Pelayo, J. Peña-Rodriguez, L.A.S. Pereira, M. Perlin, L. Perrone, C. Peters, S. Petrera, J. Phuntsok, T. Pierog, M. Pimenta, V. Pirronello, M. Platino, J. Poh, B. Pont, C. Porowski, R.R. Prado, P. Privitera, M. Prouza, A. Puyleart, S. Querchfeld, S. Quinn, R. Ramos-Pollan, J. Rautenberg, D. Ravignani, M. Reininghaus, J. Ridky, F. Riehn, M. Risse, P. Ristori, V. Rizi, W. Rodrigues de Carvalho, J. Rodriguez Rojo, M.J. Roncoroni, M. Roth, E. Roulet, A.C. Rovero, P. Ruehl, S.J. Saffi, A. Saftoiu, F. Salamida, H. Salazar, G. Salina, J.D. Sanabria Gomez, F. Sánchez, E.M. Santos, E. Santos, F. Sarazin, R. Sarmento, C. Sarmiento-Cano, R. Sato, P. Savina, M. Schauer, V. Scherini, H. Schieler, M. Schimassek, M. Schimp, F. Schlüter, D. Schmidt, O. Scholten, P. Schovánek, F.G. Schröder, S. Schröder, J. Schumacher, S.J. Sciutto, M. Scornavacche, R.C. Shellard, G. Sigl, G. Silli, O. Sima, R. Šmída, G.R. Snow, P. Sommers, J.F. Soriano, J. Souchard, R. Squartini, D. Stanca, S. Stanič, J. Stasielak, P. Stassi, M. Stolpovskiy, A. Streich, F. Suarez, M. Suárez-Durán, T. Sudholz, T. Suomijärvi, A.D. Supanitsky, J. Šupík, Z. Szadkowski, A. Taboada, O.A. Taborda, A. Tapia, C. Timmermans, C.J. Todero Peixoto, B. Tomé, G. Torralba Elipe, A. Travaini, P. Travnicek, M. Trini, M. Tueros, R. Ulrich, M. Unger, M. Urban, J.F. Valdés Galicia, I. Valiño, L. Valore, P. van Bodegom, A.M. van den Berg, A. van Vliet, E. Varela, B. Vargas Cárdenas, D. Veberič, C. Ventura, I.D. Vergara Quispe, V. Verzi, J. Vicha, L. Villaseñor, J. Vink, S. Vorobiov, H. Wahlberg, A.A. Watson, M. Weber, A. Weindl, M. Wiedeński, L. Wiencke, H. Wilczyński, T. Winchen, M. Wirtz, D. Wittkowski, B. Wundheiler, L. Yang, A. Yushkov, E. Zas, D. Zavrtanik, M. Zavrtanik, L. Zehrer, A. Zepeda, B. Zimmermann, M. Ziolkowski, Z. Zong, and F. Zuccarello
Subjects: UHECR, high energy neutrinos, high energy photons, high energy neutrons, multi-messenger astrophysics, compact binary mergers, Astronomy, QB1-991, Geophysics. Cosmic physics, QC801-809
Abstract: An overview of the multi-messenger capabilities of the Pierre Auger Observatory is presented. The techniques and performance of searching for Ultra-High Energy neutrinos, photons and neutrons are described. Some of the most relevant results are reviewed, such as stringent upper bounds that were placed to a flux of diffuse cosmogenic neutrinos and photons, bounds placed on neutrinos emitted from compact binary mergers that were detected by LIGO and Virgo during their first and second observing runs, as well as searches for high energy photons and neutrons from the Galactic center that constrain the properties of the putative Galactic PeVatron, observed by the H.E.S.S. collaboration. The observation of directional correlations between ultra-high energy cosmic rays and either high energy astrophysical neutrinos or specific source populations, weighted by their electromagnetic radiation, are also discussed. They constitute additional multi-messenger approaches aimed at identifying the sources of high energy cosmic rays.
Published: 2019
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20. Supplementary Table 1 from Long-term Benefit of PD-L1 Blockade in Lung Cancer Associated with JAK3 Activation

Author: David A. Barbie, Kwok-Kin Wong, Glenn Dranoff, Scott J. Rodig, F. Stephen Hodi, Levi A. Garraway, Peter S. Hammerman, Neal Lindeman, Gad Getz, Pasi Janne, Geoffrey Oxnard, Scott L. Carter, Lynette Sholl, Joshua Helmkamp, Alexandra R. Rabin, Joshua A. Wong, Ada G. Avila, Stacy Mach, Christine Lydon, Tran Thai, Aaron Chevalier, Vanesa Rojas-Rudilla, Maegan Harden, Marios Giannakis, Amaro Taylor-Weiner, Karrie Wong, Shohei Koyama, Yan Liu, Hadrien G. Golay, and Eliezer M. Van Allen
Abstract: Table S1: All somatic mutations and short insertion/deletions. This table provides information on all somatic point mutations and short insertion/deletions observed in the tumor sample from this patient. Additional annotations about protein change, allelic fraction, copy ratio (as segment mean), and other information are provided.
Published: 2023

21. Supplementary Figures 1 - 6, Figure Legends from Long-term Benefit of PD-L1 Blockade in Lung Cancer Associated with JAK3 Activation

Author: David A. Barbie, Kwok-Kin Wong, Glenn Dranoff, Scott J. Rodig, F. Stephen Hodi, Levi A. Garraway, Peter S. Hammerman, Neal Lindeman, Gad Getz, Pasi Janne, Geoffrey Oxnard, Scott L. Carter, Lynette Sholl, Joshua Helmkamp, Alexandra R. Rabin, Joshua A. Wong, Ada G. Avila, Stacy Mach, Christine Lydon, Tran Thai, Aaron Chevalier, Vanesa Rojas-Rudilla, Maegan Harden, Marios Giannakis, Amaro Taylor-Weiner, Karrie Wong, Shohei Koyama, Yan Liu, Hadrien G. Golay, and Eliezer M. Van Allen
Abstract: Figure S1: Orthogonal sequencing of JAK3 mutations. Figure S2: Copy number profile of tumor. Figure S3: Absolute copy number. Figure S4: PHIAL gel of patient's somatic exome results. Figure S5. Modified H-scores for tumor and immune cells. Figure S6. T cell re-activation following co-culture with JAK3-V722I expressing monocytes in the presence of MPDL3280A.
Published: 2023

22. Data from Long-term Benefit of PD-L1 Blockade in Lung Cancer Associated with JAK3 Activation

Author: David A. Barbie, Kwok-Kin Wong, Glenn Dranoff, Scott J. Rodig, F. Stephen Hodi, Levi A. Garraway, Peter S. Hammerman, Neal Lindeman, Gad Getz, Pasi Janne, Geoffrey Oxnard, Scott L. Carter, Lynette Sholl, Joshua Helmkamp, Alexandra R. Rabin, Joshua A. Wong, Ada G. Avila, Stacy Mach, Christine Lydon, Tran Thai, Aaron Chevalier, Vanesa Rojas-Rudilla, Maegan Harden, Marios Giannakis, Amaro Taylor-Weiner, Karrie Wong, Shohei Koyama, Yan Liu, Hadrien G. Golay, and Eliezer M. Van Allen
Abstract: PD-1 immune checkpoint blockade occasionally results in durable clinical responses in advanced metastatic cancers. However, mechanism-based predictors of response to this immunotherapy remain incompletely characterized. We performed comprehensive genomic profiling on a tumor and germline sample from a patient with refractory lung adenocarcinoma who achieved marked long-term clinical benefit from anti–PD-L1 therapy. We discovered activating somatic and germline amino acid variants in JAK3 that promoted PD-L1 induction in lung cancer cells and in the tumor immune microenvironment. These findings suggest that genomic alterations that deregulate cytokine receptor signal transduction could contribute to PD-L1 activation and engagement of the PD-1 immune checkpoint in lung cancer. Cancer Immunol Res; 3(8); 855–63. ©2015 AACR.
Published: 2023

23. Intoxication Associated with Ayahuasca Consumption, Characterization, and Comparative Analysis of the Beverage's Components: A Case Report

Author: Edgar A. Estrella-Parra, José G. Avila-Acevedo, Ana M. García-Bores, José C. Rivera-Cabrera, Edgar F. Alarcón-Villaseñor, Ivone Alejandre-García, and Francisco J. Alarcón-Aguilar
Subjects: Psychiatry and Mental health
Published: 2023

24. Evidence for a mixed mass composition at the ‘ankle’ in the cosmic-ray spectrum

Author: A. Aab, P. Abreu, M. Aglietta, E.J. Ahn, I. Al Samarai, I.F.M. Albuquerque, I. Allekotte, P. Allison, A. Almela, J. Alvarez Castillo, J. Alvarez-Muñiz, M. Ambrosio, G.A. Anastasi, L. Anchordoqui, B. Andrada, S. Andringa, C. Aramo, F. Arqueros, N. Arsene, H. Asorey, P. Assis, J. Aublin, G. Avila, A.M. Badescu, A. Balaceanu, C. Baus, J.J. Beatty, K.H. Becker, J.A. Bellido, C. Berat, M.E. Bertaina, P.L. Biermann, P. Billoir, J. Biteau, S.G. Blaess, A. Blanco, J. Blazek, C. Bleve, M. Boháčová, D. Boncioli, C. Bonifazi, N. Borodai, A.M. Botti, J. Brack, I. Brancus, T. Bretz, A. Bridgeman, F.L. Briechle, P. Buchholz, A. Bueno, S. Buitink, M. Buscemi, K.S. Caballero-Mora, B. Caccianiga, L. Caccianiga, A. Cancio, F. Canfora, L. Caramete, R. Caruso, A. Castellina, G. Cataldi, L. Cazon, R. Cester, A.G. Chavez, A. Chiavassa, J.A. Chinellato, J. Chudoba, R.W. Clay, R. Colalillo, A. Coleman, L. Collica, M.R. Coluccia, R. Conceição, F. Contreras, M.J. Cooper, S. Coutu, C.E. Covault, J. Cronin, R. Dallier, S. D'Amico, B. Daniel, S. Dasso, K. Daumiller, B.R. Dawson, R.M. de Almeida, S.J. de Jong, G. De Mauro, J.R.T. de Mello Neto, I. De Mitri, J. de Oliveira, V. de Souza, J. Debatin, L. del Peral, O. Deligny, C. Di Giulio, A. Di Matteo, M.L. Díaz Castro, F. Diogo, C. Dobrigkeit, J.C. D'Olivo, A. Dorofeev, R.C. dos Anjos, M.T. Dova, A. Dundovic, J. Ebr, R. Engel, M. Erdmann, M. Erfani, C.O. Escobar, J. Espadanal, A. Etchegoyen, H. Falcke, K. Fang, G. Farrar, A.C. Fauth, N. Fazzini, B. Fick, J.M. Figueira, A. Filevich, A. Filipčič, O. Fratu, M.M. Freire, T. Fujii, A. Fuster, B. García, D. Garcia-Pinto, F. Gaté, H. Gemmeke, A. Gherghel-Lascu, P.L. Ghia, U. Giaccari, M. Giammarchi, M. Giller, D. Głas, C. Glaser, H. Glass, G. Golup, M. Gómez Berisso, P.F. Gómez Vitale, N. González, B. Gookin, J. Gordon, A. Gorgi, P. Gorham, P. Gouffon, A.F. Grillo, T.D. Grubb, F. Guarino, G.P. Guedes, M.R. Hampel, P. Hansen, D. Harari, T.A. Harrison, J.L. Harton, Q. Hasankiadeh, A. Haungs, T. Hebbeker, D. Heck, P. Heimann, A.E. Herve, G.C. Hill, C. Hojvat, E. Holt, P. Homola, J.R. Hörandel, P. Horvath, M. Hrabovský, T. Huege, J. Hulsman, A. Insolia, P.G. Isar, I. Jandt, S. Jansen, J.A. Johnsen, M. Josebachuili, A. Kääpä, O. Kambeitz, K.H. Kampert, P. Kasper, I. Katkov, B. Keilhauer, E. Kemp, R.M. Kieckhafer, H.O. Klages, M. Kleifges, J. Kleinfeller, R. Krause, N. Krohm, D. Kuempel, G. Kukec Mezek, N. Kunka, A. Kuotb Awad, D. LaHurd, L. Latronico, M. Lauscher, P. Lautridou, P. Lebrun, R. Legumina, M.A. Leigui de Oliveira, A. Letessier-Selvon, I. Lhenry-Yvon, K. Link, L. Lopes, R. López, A. López Casado, Q. Luce, A. Lucero, M. Malacari, M. Mallamaci, D. Mandat, P. Mantsch, A.G. Mariazzi, I.C. Mariş, G. Marsella, D. Martello, H. Martinez, O. Martínez Bravo, J.J. Masías Meza, H.J. Mathes, S. Mathys, J. Matthews, J.A.J. Matthews, G. Matthiae, E. Mayotte, P.O. Mazur, C. Medina, G. Medina-Tanco, D. Melo, A. Menshikov, S. Messina, M.I. Micheletti, L. Middendorf, I.A. Minaya, L. Miramonti, B. Mitrica, D. Mockler, L. Molina-Bueno, S. Mollerach, F. Montanet, C. Morello, M. Mostafá, G. Müller, M.A. Muller, S. Müller, I. Naranjo, S. Navas, L. Nellen, J. Neuser, P.H. Nguyen, M. Niculescu-Oglinzanu, M. Niechciol, L. Niemietz, T. Niggemann, D. Nitz, D. Nosek, V. Novotny, H. Nožka, L.A. Núñez, L. Ochilo, F. Oikonomou, A. Olinto, D. Pakk Selmi-Dei, M. Palatka, J. Pallotta, P. Papenbreer, G. Parente, A. Parra, T. Paul, M. Pech, F. Pedreira, J. Pȩkala, R. Pelayo, J. Peña-Rodriguez, L.A.S. Pereira, L. Perrone, C. Peters, S. Petrera, J. Phuntsok, R. Piegaia, T. Pierog, P. Pieroni, M. Pimenta, V. Pirronello, M. Platino, M. Plum, C. Porowski, R.R. Prado, P. Privitera, M. Prouza, E.J. Quel, S. Querchfeld, S. Quinn, R. Ramos-Pollant, J. Rautenberg, O. Ravel, D. Ravignani, D. Reinert, B. Revenu, J. Ridky, M. Risse, P. Ristori, V. Rizi, W. Rodrigues de Carvalho, G. Rodriguez Fernandez, J. Rodriguez Rojo, M.D. Rodríguez-Frías, D. Rogozin, J. Rosado, M. Roth, E. Roulet, A.C. Rovero, S.J. Saffi, A. Saftoiu, H. Salazar, A. Saleh, F. Salesa Greus, G. Salina, J.D. Sanabria Gomez, F. Sánchez, P. Sanchez-Lucas, E.M. Santos, E. Santos, F. Sarazin, B. Sarkar, R. Sarmento, C. Sarmiento-Cano, R. Sato, C. Scarso, M. Schauer, V. Scherini, H. Schieler, D. Schmidt, O. Scholten, P. Schovánek, F.G. Schröder, A. Schulz, J. Schulz, J. Schumacher, S.J. Sciutto, A. Segreto, M. Settimo, A. Shadkam, R.C. Shellard, G. Sigl, G. Silli, O. Sima, A. Śmiałkowski, R. Šmída, G.R. Snow, P. Sommers, S. Sonntag, J. Sorokin, R. Squartini, D. Stanca, S. Stanič, J. Stasielak, F. Strafella, F. Suarez, M. Suarez Durán, T. Sudholz, T. Suomijärvi, A.D. Supanitsky, M.S. Sutherland, J. Swain, Z. Szadkowski, O.A. Taborda, A. Tapia, A. Tepe, V.M. Theodoro, C. Timmermans, C.J. Todero Peixoto, L. Tomankova, B. Tomé, A. Tonachini, G. Torralba Elipe, D. Torres Machado, M. Torri, P. Travnicek, M. Trini, R. Ulrich, M. Unger, M. Urban, A. Valbuena-Delgado, J.F. Valdés Galicia, I. Valiño, L. Valore, G. van Aar, P. van Bodegom, A.M. van den Berg, A. van Vliet, E. Varela, B. Vargas Cárdenas, G. Varner, J.R. Vázquez, R.A. Vázquez, D. Veberič, V. Verzi, J. Vicha, L. Villaseñor, S. Vorobiov, H. Wahlberg, O. Wainberg, D. Walz, A.A. Watson, M. Weber, A. Weindl, L. Wiencke, H. Wilczyński, T. Winchen, D. Wittkowski, B. Wundheiler, S. Wykes, L. Yang, D. Yelos, P. Younk, A. Yushkov, E. Zas, D. Zavrtanik, M. Zavrtanik, A. Zepeda, B. Zimmermann, M. Ziolkowski, Z. Zong, and F. Zuccarello
Subjects: Physics, QC1-999
Abstract: We report a first measurement for ultrahigh energy cosmic rays of the correlation between the depth of shower maximum and the signal in the water Cherenkov stations of air-showers registered simultaneously by the fluorescence and the surface detectors of the Pierre Auger Observatory. Such a correlation measurement is a unique feature of a hybrid air-shower observatory with sensitivity to both the electromagnetic and muonic components. It allows an accurate determination of the spread of primary masses in the cosmic-ray flux. Up till now, constraints on the spread of primary masses have been dominated by systematic uncertainties. The present correlation measurement is not affected by systematics in the measurement of the depth of shower maximum or the signal in the water Cherenkov stations. The analysis relies on general characteristics of air showers and is thus robust also with respect to uncertainties in hadronic event generators. The observed correlation in the energy range around the ‘ankle’ at lg⁡(E/eV)=18.5–19.0 differs significantly from expectations for pure primary cosmic-ray compositions. A light composition made up of proton and helium only is equally inconsistent with observations. The data are explained well by a mixed composition including nuclei with mass A>4. Scenarios such as the proton dip model, with almost pure compositions, are thus disfavored as the sole explanation of the ultrahigh-energy cosmic-ray flux at Earth. Keywords: Pierre Auger Observatory, Cosmic rays, Mass composition, Ankle
Published: 2016
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25. Genome biology of the darkedged splitfin, Girardinichthys multiradiatus, and the evolution of sex chromosomes and placentation

Author: Kang Du, Martin Pippel, Susanne Kneitz, Romain Feron, Irene da Cruz, Sylke Winkler, Brigitta Wilde, Edgar G. Avila Luna, Gene Myers, Yann Guiguen, Constantino Macias Garcia, and Manfred Schartl
Subjects: Genetics, Genetics (clinical)
Abstract: Viviparity evolved independently about 150 times in vertebrates and more than 20 times in fish. Several lineages added to the protection of the embryo inside the body of the mother, the provisioning of nutrients, and physiological exchange. This often led to the evolution of a placenta. Among fish, one of the most complex systems serving the function of the placenta is the embryonal trophotaenia/ovarian luminal epithelium of the goodeid fishes. For a better understanding of this feature and others of this group of fishes, high-quality genomic resources are essential. We have sequenced the genome of the darkedged splitfin, Girardinichthys multiradiatus. The assembly is chromosome level and includes the X and Y Chromosomes. A large male-specific region on the Y was identified covering 80% of Chromosome 20, allowing some first inferences on the recent origin and a candidate male sex determining gene. Genome-wide transcriptomics uncovered sex-specific differences in brain gene expression with an enrichment for neurosteroidogenesis and testis genes in males. The expression signatures of the splitfin embryonal and maternal placenta showed overlap with homologous tissues including human placenta, the ovarian follicle epithelium of matrotrophic poeciliid fish species and the brood pouch epithelium of the seahorse. Our comparative analyses on the evolution of embryonal and maternal placenta indicate that the evolutionary novelty of maternal provisioning development repeatedly made use of genes that already had the same function in other tissues. In this way, preexisting modules are assembled and repurposed to provide the molecular changes for this novel trait.
Published: 2022

26. Pediatric trauma in the California-Mexico border region: Injury disparities by Area Deprivation Index

Author: Alicia Gaidry, Sykes, Alexandra S, Rooney, Andrew G, Avila, Claudio B, Ghetti, Matthew J, Martin, Vishal, Bansal, Michael J, Sise, and Romeo C, Ignacio
Subjects: Social Class, Trauma Centers, Residence Characteristics, Humans, Surgery, Child, Critical Care and Intensive Care Medicine, Mexico, California
Abstract: The California-Mexico border region is a high-volume trauma area with populations of widely disparate socioeconomic status. This work analyzed differences in demographics and mechanism of injury in children using the Area Deprivation Index (ADI), a composite measure of 17 markers of neighborhood socioeconomic disadvantage.A retrospective review was performed of pediatric patients evaluated at the regional Level I Pediatric Trauma Center between 2008 and 2018. Collected data included patient demographics and injury characteristics. Patient addresses were correlated to neighborhood disadvantage level using ADI quintiles, with a higher quintile representing greater socioeconomic disadvantage.A total of 9,715 children were identified, of which 4,307 (44%) were Hispanic. Hispanic children were more likely to live in more disadvantaged neighborhoods than non-Hispanic children (p0.001). There were markedly different injury mechanisms in neighborhoods with greater socioeconomic disadvantage (higher ADI) compared with those with less socioeconomic disadvantage. Sports-related and nonmotorized vehicular trauma predominated in less disadvantaged neighborhoods, while higher ADI quintiles were strongly associated with pedestrian versus automobile, motorized vehicle accidents/collisions, and nonaccidental injuries (p0.001).This analysis represents the first study to characterize pediatric traumatic injury patterns based upon the neighborhood ADI metric. Area Deprivation Index can be a useful resource in identifying disparities in pediatric trauma and children at increased risk for vehicular and abusive injury who may benefit from increased resource allocation, social support, and prevention programs.Prognostic and epidemiological, Level III.
Published: 2022

27. Water quality probe co-design for water monitoring in rural communities in Colombia

Author: Pinto, Darwin D. Rodriguez, primary, Taborda, Jaime A. Perez, additional, Rodriguez, Cesar G. Franco, additional, Martinez, Rodrigo Gomez, additional, and Bernal, Alba G. Avila, additional
Published: 2022
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28. Development of a Bottom-up Compact Model for Intel®’s High-K 45 nm MOSFET

Author: Rodriguez, David E. Espejo, Bernal, Alba G. Ávila, Kim, Haeng Kon, editor, Ao, Sio-Iong, editor, and Rieger, Burghard B., editor
Published: 2013
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29. MicroRNA-204/CREB5 axis regulates vasculogenic mimicry in breast cancer cells

Author: Contreras-Sanzón, Estefania, primary, Palma-Flores, Carlos, additional, Flores-Pérez, Ali, additional, M. Salinas-Vera, Yarely, additional, B. Silva-Cázares, Macrina, additional, A. Marchat, Laurence, additional, G. Avila-Bonilla, Rodolfo, additional, N. Hernández de la Cruz, Olga, additional, E. Álvarez-Sánchez, María, additional, Pérez-Plasencia, Carlos, additional, D. Campos-Parra, Alma, additional, and López-Camarillo, César, additional
Published: 2022
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30. Immunosuppression: A Hidden Component of Virchows' Triad

Author: C. Tejera Quesada, J. Baek, R. Reddy, A. Rodriguez, and G. Avila Amat
Published: 2022

31. Microbial Antagonists from Different Environments Used in the Biocontrol of Plant Pathogens

Author: S. Droby, R. R. Gonzalez-Estrada, G. Avila-Quezada, P. Durán, G. Manzo-Sánchez, and L. G. Hernandez-Montiel
Published: 2022

32. The impact of atmospheric dispersion in the performance of high-resolution spectrographs

Author: G. Avila, Alexandre Cabral, P. Figueira, Nuno C. Santos, J. H. C. Martins, and Bachar Wehbe
Subjects: Physics, Work (thermodynamics), media_common.quotation_subject, Astrophysics::Instrumentation and Methods for Astrophysics, FOS: Physical sciences, Flux, Astronomy and Astrophysics, Atmospheric dispersion modeling, 01 natural sciences, Computational physics, 010309 optics, Radial velocity, Atmosphere, Space and Planetary Science, Position (vector), Sky, 0103 physical sciences, Dispersion (optics), Astrophysics - Instrumentation and Methods for Astrophysics, Instrumentation and Methods for Astrophysics (astro-ph.IM), 010303 astronomy & astrophysics, media_common
Abstract: Differential atmospheric dispersion is a wavelength-dependent effect introduced by the atmosphere. It is one of the instrumental errors that can affect the position of the target as perceived on the sky and its flux distribution. This effect will affect the results of astronomical observations if not corrected by an atmospheric dispersion corrector (ADC). In high-resolution spectrographs, in order to reach a radial velocity (RV) precision of 10 cm/s, an ADC is expected to return residuals at only a few tens of milli-arcseconds (mas). In fact, current state-of-the-art spectrographs conservatively require this level of residuals, although no work has been done to quantify the impact of atmospheric dispersion. In this work we test the effect of atmospheric dispersion on astronomical observations in general, and in particular on RV precision degradation and flux losses. Our scientific objective was to quantify the amount of residuals needed to fulfill the requirements set on an ADC during the design phase. We found that up to a dispersion of 100 mas, the effect on the RV is negligible. However, on the flux losses, such a dispersion can create a loss of ~2% at 380 nm, a significant value when efficiency is critical. The requirements set on ADC residuals should take into consideration the atmospheric conditions where the ADC will function, and also all the aspects related with not only the RV precision requirements but also the guiding camera used, the tolerances on the flux loss, and the different melt data of the chosen glasses., Comment: accepted for publications in MNRAS
Published: 2019

33. PANLAR consensus statement on biosimilars

Author: M. E. L. Lopez, G. Avila-Pedretti, J. A. Benavides, A. M. Babini, A. P. Ortega, V. F. Azevedo, I. S. Terán, C. Encalada, Pedro Santos-Moreno, Claudio Galarza-Maldonado, S. B. Cohen, B. Garro, Jonathan Kay, Ricardo Machado Xavier, V. J. K. Rodriguez, Sergio Kowalski, Enrique R. Soriano, M. Cifuentes-Alvarado, Antonio Cachafeiro-Vilar, Eduardo Mysler, Carlos Pineda, A. Vargas, P. A. B. Roa, Marlene Guibert-Toledano, A. S. Russell, L. Diaz Soto, Gloria Vásquez, I. A. G. Sariego, D. X. Xibillé Firedman, P. E. Díaz, and Carlo V. Caballero-Uribe
Subjects: medicine.medical_specialty, Consensus, Traceability, Modified delphi, 03 medical and health sciences, 0302 clinical medicine, Rheumatology, Rheumatic Diseases, Pharmacovigilance, medicine, Humans, 030212 general & internal medicine, Biosimilar Pharmaceuticals, Societies, Medical, Risk management, computer.programming_language, 030203 arthritis & rheumatology, Evidence-Based Medicine, business.industry, Treatment options, Biosimilar, General Medicine, Latin America, Family medicine, North America, Practice Guidelines as Topic, business, computer, Delphi
Abstract: Biologics have improved the treatment of rheumatic diseases, resulting in better outcomes. However, their high cost limits access for many patients in both North America and Latin America. Following patent expiration for biologicals, the availability of biosimilars, which typically are less expensive due to lower development costs, provides additional treatment options for patients with rheumatic diseases. The availability of biosimilars in North American and Latin American countries is evolving, with differing regulations and clinical indications. The objective of the study was to present the consensus statement on biosimilars in rheumatology developed by Pan American League of Associations for Rheumatology (PANLAR). Using a modified Delphi process approach, the following topics were addressed: regulation, efficacy and safety, extrapolation of indications, interchangeability, automatic substitution, pharmacovigilance, risk management, naming, traceability, registries, economic aspects, and biomimics. Consensus was achieved when there was agreement among 80% or more of the panel members. Three Delphi rounds were conducted to reach consensus. Questionnaires were sent electronically to panel members and comments about each question were solicited. Eight recommendations were formulated regarding regulation, pharmacovigilance, risk management, naming, traceability, registries, economic aspects, and biomimics. The recommendations highlighted that, after receiving regulatory approval, pharmacovigilance is a fundamental strategy to ensure safety of all medications. Registries should be employed to monitor use of biosimilars and to identify potential adverse effects. The price of biosimilars should be significantly lower than that of reference products to enhance patient access. Biomimics are not biosimilars and, if they are to be marketed, they must first be evaluated and approved according to established regulatory pathways for novel biopharmaceuticals. • Biologics have improved the treatment of rheumatic diseases. • Their high cost limits access for many patients in both North America and Latin America. • Biosimilars typically are less expensive, providing additional treatment options for patients with rheumatic diseases. • PANLAR presents its consensus on biosimilars in rheumatology
Published: 2019

34. Antioxidant and anti-inflammatory effects of extracts from Maqui berry Aristotelia chilensis in human colon cancer cells

Author: Zhao-Jun Wei, Longsheng Chen, Enrique Werner-Navarrete, Jose G. Avila, Isao Kubo, Jianbo Xiao, José M Bastías, Julio Alarcón-Enos, and Carlos L. Cespedes-Acuña
Subjects: Antioxidant, biology, Traditional medicine, medicine.drug_class, Chemistry, medicine.medical_treatment, Soil Science, 04 agricultural and veterinary sciences, Plant Science, Berry, Horticulture, biology.organism_classification, 040401 food science, Biochemistry, Anti-inflammatory, Human colon cancer, 03 medical and health sciences, 0404 agricultural biotechnology, 0302 clinical medicine, Aristotelia chilensis, Polyphenol, 030220 oncology & carcinogenesis, medicine, Agronomy and Crop Science, Food Science
Published: 2018

35. Genome biology of the darkedged splitfin

Author: Kang, Du, Martin, Pippel, Susanne, Kneitz, Romain, Feron, Irene, da Cruz, Sylke, Winkler, Brigitta, Wilde, Edgar G, Avila Luna, Gene, Myers, Yann, Guiguen, Constantino, Macias Garcia, and Manfred, Schartl
Subjects: Male, Cyprinodontiformes, Genome, Sex Chromosomes, Pregnancy, Animals, Female, Biology, Placentation
Abstract: Viviparity evolved independently about 150 times in vertebrates and more than 20 times in fish. Several lineages added to the protection of the embryo inside the body of the mother, the provisioning of nutrients, and physiological exchange. This often led to the evolution of a placenta. Among fish, one of the most complex systems serving the function of the placenta is the embryonal trophotaenia/ovarian luminal epithelium of the goodeid fishes. For a better understanding of this feature and others of this group of fishes, high-quality genomic resources are essential. We have sequenced the genome of the darkedged splitfin
Published: 2021

36. EuroGuiDerm Guideline on the systemic treatment of Psoriasis vulgaris - Part 2: specific clinical and comorbid situations

Author: Ulrich Mrowietz, O. Sundnes, Alexander Nast, E De Jong, Zsuzsanna Bata-Csorgo, Catherine H. Smith, G. E. van der Kraaij, Paolo Gisondi, Ignacio García-Doval, Marcus Schmitt-Egenolf, Nikhil Yawalkar, K.M. Ronholt, S. Mburu, T. Malkonen, Mariusz Sikora, H Boonen, Satveer K. Mahil, G. Avila Valle, Corinna Dressler, Klaus Strömer, D. Kaur-Knudsen, P.G. Sator, Ph.I. Spuls, Éva Remenyik, Julia-Tatjana Maul, Kristian Reich, D. Trigos, Dermatology, AII - Inflammatory diseases, APH - Methodology, APH - Quality of Care, Experimental Immunology, Graduate School, APH - Personalized Medicine, Department of Dermatology, Allergology and Venereology, HUS Inflammation Center, and Helsinki University Hospital Area
Subjects: medicine.medical_specialty, Tuberculosis, 610 Medicine & health, Disease, Dermatology, Inflammatory bowel disease, 030207 dermatology & venereal diseases, 03 medical and health sciences, Psoriatic arthritis, 0302 clinical medicine, All institutes and research themes of the Radboud University Medical Center, Psoriasis, medicine, Humans, Dermatologi och venereologi, 030212 general & internal medicine, Intensive care medicine, Suicidal ideation, business.industry, COVID-19, Guideline, medicine.disease, 3. Good health, Dermatology and Venereal Diseases, Infectious Diseases, 3121 General medicine, internal medicine and other clinical medicine, Concomitant, Inflammatory diseases Radboud Institute for Health Sciences [Radboudumc 5], medicine.symptom, business
Abstract: This evidence- and consensus-based guideline on the treatment of psoriasis vulgaris was developed following the EuroGuiDerm Guideline and Consensus Statement Development Manual. The second part of the guideline provides guidance for specific clinical and comorbid situations such as treating psoriasis vulgaris patient with concomitant psoriatic arthritis, concomitant inflammatory bowel disease, a history of malignancies or a history of depression or suicidal ideation. It further holds recommendations for concomitant diabetes, viral hepatitis, disease affecting the heart or the kidneys as well as concomitant neurological disease. Advice on how to screen for tuberculosis and recommendations on how to manage patients with a positive tuberculosis test result are given. It further covers treatment for pregnant women or patients with a wish for a child in the near future. Information on vaccination, immunogenicity and systemic treatment during the COVID-19 pandemic is also provided.
Published: 2021

37. ESPRESSO high-resolution transmission spectroscopy of WASP-76 b

Author: S. Hojjatpanah, L. Genolet, Matteo Genoni, Paolo Molaro, Edoardo Maria Alberto Redaelli, T. Bandy, A. Segovia, Jorge Lillo-Box, Diogo Alves, A. Suárez Mascareño, Olivier Demangeon, Vincent Bourrier, João P. Faria, Julia V. Seidel, F. Tenegi, P. Figueira, Yann Alibert, Danuta Sosnowska, Giorgio Pariani, Matteo Aliverti, Antonino Bianco, M. Moschetti, J. Knudstrup, B. Delabre, M. Amate, Romain Allart, Olaf Iwert, Valentina D'Odorico, Francesco Borsa, Hugo M. Tabernero, J. L. Lizon, M. R. Zapatero Osorio, G. Avila, Paolo Conconi, Vardan Adibekyan, Alexandre Cabral, Ennio Poretti, Mário J. P. F. G. Monteiro, J. L. Rasilla, Andrea Mehner, Antonio Gouveia Oliveira, Filippo Maria Zerbi, Alessandro Sozzetti, François Bouchy, Luca Pasquini, Baptiste Lavie, Marco Landoni, E. Mueller, S. Deiries, Luca Oggioni, Nelson J. Nunes, R. Génova Santos, Claudio Cumani, João Coelho, S. C. C. Barros, Denis Mégevand, J. I. González Hernández, S. Santana-Tschudi, Paolo Santin, M. Affolter, Giuseppina Micela, Alessio Zanutta, G. Lo Curto, A. Fragoso, C. Allende Prieto, Pedro Santos, J. H. C. Martins, Antonio Manescau, Florian Kerber, Willy Benz, Hans Dekker, David Ehrenreich, Paolo Spanò, Rafael Rebolo, Xavier Dumusque, Cristina Martins, Núria Casasayas-Barris, Francesco Pepe, S. G. Sousa, Stefano Cristiani, C. Broeg, C. Maire, Andrea Modigliani, Stéphane Udry, Nuno C. Santos, Marco Riva, C. Lovis, Enric Palle, I. Hughes, P. Di Marcantonio, ITA, ESP, PRT, and CHE
Subjects: 530 Physics, Continuum (design consultancy), FOS: Physical sciences, Astrophysics, 01 natural sciences, Molecular physics, Spectral line, Atmosphere, Espresso, Planet, 0103 physical sciences, Irradiation, 010303 astronomy & astrophysics, Spectrograph, Solar and Stellar Astrophysics (astro-ph.SR), Earth and Planetary Astrophysics (astro-ph.EP), Physics, 010308 nuclear & particles physics, 520 Astronomy, Astronomy and Astrophysics, 500 Science, 620 Engineering, Transmission (telecommunications), Astrophysics - Solar and Stellar Astrophysics, Space and Planetary Science, Astrophysics - Earth and Planetary Astrophysics
Abstract: Aims. We report on ESPRESSO high-resolution transmission spectroscopic observations of two primary transits of the highly-irradiated, ultra-hot Jupiter-size planet WASP-76b. We investigate the presence of several key atomic and molecular features of interest that may reveal the atmospheric properties of the planet. Methods. We extracted two transmission spectra of WASP-76b with R approx 140,000 using a procedure that allowed us to process the full ESPRESSO wavelength range (3800-7880 A) simultaneously. We observed that at a high signal-to-noise ratio, the continuum of ESPRESSO spectra shows wiggles that are likely caused by an interference pattern outside the spectrograph. To search for the planetary features, we visually analysed the extracted transmission spectra and cross-correlated the observations against theoretical spectra of different atomic and molecular species. Results. The following atomic features are detected: Li I, Na I, Mg I, Ca II, Mn I, K I, and Fe I. All are detected with a confidence level between 9.2 sigma (Na I) and 2.8 sigma (Mg I). We did not detect the following species: Ti I, Cr I, Ni I, TiO, VO, and ZrO. We impose the following 1 sigma upper limits on their detectability: 60, 77, 122, 6, 8, and 8 ppm, respectively. Conclusions. We report the detection of Li I on WASP-76b for the first time. In addition, we found the presence of Na I and Fe I as previously reported in the literature. We show that the procedure employed in this work can detect features down to the level of ~ 0.1 % in the transmission spectrum and ~ 10 ppm by means of a cross-correlation method. We discuss the presence of neutral and singly ionised features in the atmosphere of WASP-76b., 20 pages, 19 figures, accepted for publication in Astronomy and Astrophysics
Published: 2021
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38. On-sky measurements of atmospheric dispersion: II. Atmospheric models characterization

Author: Luca Sbordone, G. Avila, Alexandre Cabral, and Bachar Wehbe
Subjects: media_common.quotation_subject, FOS: Physical sciences, 01 natural sciences, Spectral line, 010309 optics, 0103 physical sciences, Range (statistics), Astrophysics::Solar and Stellar Astrophysics, 010303 astronomy & astrophysics, Zemax, Instrumentation and Methods for Astrophysics (astro-ph.IM), Remote sensing, media_common, Physics, Earth and Planetary Astrophysics (astro-ph.EP), Atmospheric models, Astrophysics::Instrumentation and Methods for Astrophysics, Centroid, Astronomy and Astrophysics, Atmospheric dispersion modeling, Wavelength, Space and Planetary Science, Sky, Astrophysics::Earth and Planetary Astrophysics, Astrophysics - Instrumentation and Methods for Astrophysics, Astrophysics - Earth and Planetary Astrophysics
Abstract: Differential atmospheric dispersion is a wavelength-dependent effect introduced by Earth's atmosphere that affects astronomical observations performed using ground-based telescopes. It is important, when observing at a zenithal angle different from zero, to use an Atmospheric Dispersion Corrector (ADC) to compensate this atmospheric dispersion. The design of an ADC is based on atmospheric models that, to the best of our knowledge, were never tested against on-sky measurements. We present an extensive models analysis in the wavelength range of 315-665 nm. The method we used was previously described in the paper I of this series. It is based on the use of cross-dispersion spectrographs to determine the position of the centroid of the spatial profile at each wavelength of each spectral order. The accuracy of the method is 18 mas. At this level, we are able to compare and characterize the different atmospheric dispersion models of interest. For better future ADC designs, we recommend to avoid the Zemax model, and in particular in the blue range of the spectra, when expecting residuals at the level of few tens of milli-arcseconds., Comment: Accepted for publications in MNRAS
Published: 2021
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39. ESPRESSO at VLT. On-sky performance and first results

Author: G. Avila, Alexandre Cabral, Andrea Mehner, S. Deiries, C. Allende Prieto, Vardan Adibekyan, Roberto Cirami, Manuel Abreu, Luca Pasquini, M. Affolter, Luca Oggioni, Igor Coretti, Nelson J. Nunes, J. Knudstrup, G. Lo Curto, Nuno C. Santos, C. Lovis, Enric Palle, Damien Ségransan, Filippo Maria Zerbi, Yann Alibert, Jose Luis Rasilla, I. Hughes, A. Fragoso, S. Santana Tschudi, T. M. Schmidt, Romain Allart, Florian Kerber, Antonino Bianco, R. Génova Santos, Mahmoudreza Oshagh, Matteo Genoni, A. Segovia, João P. Faria, Rafael Rebolo, Vincent Bourrier, M. Moschetti, Olivier Demangeon, M. A. Monteiro, Marco Landoni, Danuta Sosnowska, Valentina D'Odorico, Willy Benz, P. Figueira, François Bouchy, Baptiste Lavie, Andrea Modigliani, Marco Riva, L. Genolet, Matteo Aliverti, Paolo Santin, B. Delabre, Paolo Molaro, J. L. Lizon, F. Tenegi, M. R. Zapatero Osorio, Antonio Gouveia Oliveira, Francesco Pepe, Paolo Conconi, Stéphane Udry, Guido Cupani, Hugo M. Tabernero, S. G. Sousa, José Manuel Rebordão, Hans Dekker, T. Bandy, Ennio Poretti, S. C. C. Barros, D. Álvarez, A. Suárez Mascareño, Stefano Cristiani, C. Maire, J. I. González Hernández, Giuseppina Micela, Giorgio Calderone, V. Baldini, Xavier Dumusque, Alessandro Sozzetti, Claudio Cumani, João Coelho, M. Amate, Francesco Borsa, Olaf Iwert, Denis Mégevand, Cristina Martins, Antonio Manescau, Alessio Zanutta, Michael T. Murphy, C. Broeg, Mario Damasso, M. Mayor, Jorge Lillo-Box, Pedro Santos, P. Di Marcantonio, P. Spano, Edoardo Maria Alberto Redaelli, Diogo Alves, Giorgio Pariani, Mário J. P. F. G. Monteiro, David Ehrenreich, Unidad de Excelencia Científica María de Maeztu Centro de Astrobiología del Instituto Nacional de Técnica Aeroespacial y CSIC, MDM-2017-0737, Swiss National Science Foundation (SNSF), Fundacao para a Ciencia e a Tecnologia (FCT), European Research Council (ERC), Agencia Estatal de Investigación (AEI), and Australian Research Council
Subjects: Accuracy and precision, FOS: Physical sciences, Context (language use), Astrophysics, 01 natural sciences, 7. Clean energy, law.invention, 010309 optics, Telescope, Espresso, Observatory, law, 0103 physical sciences, miscellaneous [Cosmology], spectrographs [Instrumentation], 010303 astronomy & astrophysics, Spectrograph, Instrumentation and Methods for Astrophysics (astro-ph.IM), Physics, Earth and Planetary Astrophysics (astro-ph.EP), Very Large Telescope, radial velocities [Techniques], Asteroseismology, Astronomy, Astronomy and Astrophysics, Exoplanet, detection [Planets and satellites], Space and Planetary Science, atmospheres [Planets and satellites], Astrophysics - Instrumentation and Methods for Astrophysics, Astrophysics - Earth and Planetary Astrophysics
Abstract: ESPRESSO is the new high-resolution spectrograph of ESO's Very-Large Telescope (VLT). It was designed for ultra-high radial-velocity precision and extreme spectral fidelity with the aim of performing exoplanet research and fundamental astrophysical experiments with unprecedented precision and accuracy. It is able to observe with any of the four Unit Telescopes (UT) of the VLT at a spectral resolving power of 140,000 or 190,000 over the 378.2 to 788.7 nm wavelength range, or with all UTs together, turning the VLT into a 16-m diameter equivalent telescope in terms of collecting area, while still providing a resolving power of 70,000. We provide a general description of the ESPRESSO instrument, report on the actual on-sky performance, and present our Guaranteed-Time Observation (GTO) program with its first results. ESPRESSO was installed on the Paranal Observatory in fall 2017. Commissioning (on-sky testing) was conducted between December 2017 and September 2018. The instrument saw its official start of operations on October 1st, 2018, but improvements to the instrument and re-commissioning runs were conducted until July 2019. The measured overall optical throughput of ESPRESSO at 550 nm and a seeing of 0.65 arcsec exceeds the 10% mark under nominal astro-climatic conditions. We demonstrate a radial-velocity precision of better than 25 cm/s during one night and 50 cm/s over several months. These values being limited by photon noise and stellar jitter show that the performanceis compatible with an instrumental precision of 10 cm/s. No difference has been measured across the UTs neither in throughput nor RV precision. The combination of the large collecting telescope area with the efficiency and the exquisite spectral fidelity of ESPRESSO opens a new parameter space in RV measurements, the study of planetary atmospheres, fundamental constants, stellar characterisation and many other fields., 26 pages, 28 figures
Published: 2021

40. ESPRESSO Fiber-Link upgrade. I: Project overview and performances

Author: Matteo Genoni, Felix Gracia Temich, G. Avila, Jose Luis Rasilla, Bruno Chazelas, Marco Riva, I. Hughes, Matteo Aliverti, Giorgio Pariani, Luca Oggioni, Edoardo Maria Alberto Redaelli, Denis Mégevand, and Francesco Pepe
Subjects: Optical efficiency, business.industry, Computer science, Fiber (computer science), Astrophysics::Instrumentation and Methods for Astrophysics, Astrophysics::Cosmology and Extragalactic Astrophysics, Espresso, Reliability (semiconductor), Upgrade, Observatory, Astrophysics::Solar and Stellar Astrophysics, Astrophysics::Earth and Planetary Astrophysics, business, Throughput (business), Spectrograph, Astrophysics::Galaxy Astrophysics, Computer hardware
Abstract: ESPRESSO is a high resolution, super stable fiber-fed echelle spectrograph, installed at the ESO-VLT Combined Coude Laboratory of the Paranal Observatory. The main instrument subsystems are: Coude Path, Fiber Link (FL) and Spectrograph. After installation and verification, the FL subsystem flux efficiency did not fully meet the requirements. We describe the FL subsystem upgrade, required in order to improve the optical efficiency and to meet the throughput specifications. We present the opto-mechanical design improvements, aimed to ensure proper reliability and stability of the FL subsystem both in the alignment phase and in the integration on the spectrograph. Moreover, we summarize the activities done for the different units along the upgrade phases: AIT in laboratory, FL subsystem integration on the spectrograph at VLT and on-site efficiency verifications. Measurements done before and during instrument re- commissioning show a throughput improvement of more than 30%.
Published: 2020

41. MARVEL, a four-telescope array for high-precision radial-velocity monitoring

Author: Ignasi Ribas, S. Halverson, Hugues Sana, S. Prins, G. Avila, Bart Vandenbussche, J. Perez Padilla, J. Stuermer, L. Decin, Manuel Guedel, Denis Defrere, A. Glasse, Don Pollacco, Andrew Tkachenko, Lars A. Buchhave, David H. Atkinson, Giovanna Tinetti, Alexis Brandeker, Pierre Royer, Cyprien Lanthermann, Gert Raskin, Jacob Pember, J. De Ridder, H. Van Winckel, Christian Schwab, Johan Morren, Evans, CJ, Bryant, JJ, Motohara, K, Evans, Christopher J., Bryant, Julia J., and Motohara, Kentaro
Subjects: Physics, Radial velocity, Optical fiber, Spectrograph, media_common.quotation_subject, Astrophysics::Instrumentation and Methods for Astrophysics, FOS: Physical sciences, Astronomy, Exoplanet, Space exploration, law.invention, Telescope, Planet, Observatory, law, Sky, Astrophysics::Solar and Stellar Astrophysics, Astrophysics::Earth and Planetary Astrophysics, Astrophysics - Instrumentation and Methods for Astrophysics, Instrumentation and Methods for Astrophysics (astro-ph.IM), Astrophysics::Galaxy Astrophysics, Telescopes, media_common
Abstract: Since the first discovery of a planet outside of our Solar System in 1995, exoplanet research has shifted from detecting to characterizing worlds around other stars. The TESS (NASA, launched 2019) and PLATO mission (ESA, planned launch 2026) will find and constrain the size of thousands of exoplanets around bright stars all over the sky. Radial velocity measurements are needed to characterize the orbit and mass, and complete the picture of densities and composition of the exoplanet systems found. The Ariel mission (ESA, planned launch 2028) will characterize exoplanet atmospheres with infrared spectroscopy. Characterization of stellar activity using optical spectroscopy from the ground is key to retrieve the spectral footprint of the planetary atmosphere in Ariel's spectra. To enable the scientific harvest of the TESS, PLATO and Ariel space missions, we plan to install MARVEL as an extension of the existing Mercator Telescope at the Roque De Los Muchachos Observatory on La Palma (SPAIN). MARVEL consists of an array of four 80 cm telescopes linked through optical fibers to a single high-resolution echelle spectrograph, optimized for extreme-precision radial velocity measurements. It can observe the radial velocities of four different stars simultaneously or, alternatively, combine the flux from four telescopes pointing to a single faint target in one spectrum. MARVEL is constructed by a KU Leuven (Belgium) led collaboration, with contributions from the UK, Austria, Australia, Sweden, Denmark and Spain. In this paper, we present the MARVEL instrument with special focus on the optical design and expected performance of the spectrograph, and report on the status of the project., SPIE Astronomical Telescopes + Instrumentation 2020, Ground-based and Airborne Instrumentation for Astronomy VIII
Published: 2020

42. Ultrahigh Energy Neutrinos at the Pierre Auger Observatory

Author: P. Abreu, M. Aglietta, M. Ahlers, E. J. Ahn, I. F. M. Albuquerque, D. Allard, I. Allekotte, J. Allen, P. Allison, A. Almela, J. Alvarez Castillo, J. Alvarez-Muñiz, R. Alves Batista, M. Ambrosio, A. Aminaei, L. Anchordoqui, S. Andringa, T. Antičić, C. Aramo, E. Arganda, F. Arqueros, H. Asorey, P. Assis, J. Aublin, M. Ave, M. Avenier, G. Avila, T. Bäcker, A. M. Badescu, M. Balzer, K. B. Barber, A. F. Barbosa, R. Bardenet, S. L. C. Barroso, B. Baughman, J. Bäuml, J. J. Beatty, B. R. Becker, K. H. Becker, A. Bellétoile, J. A. Bellido, S. BenZvi, C. Berat, X. Bertou, P. L. Biermann, P. Billoir, F. Blanco, M. Blanco, C. Bleve, H. Blümer, M. Boháčová, D. Boncioli, C. Bonifazi, R. Bonino, N. Borodai, J. Brack, I. Brancus, P. Brogueira, W. C. Brown, R. Bruijn, P. Buchholz, A. Bueno, R. E. Burton, K. S. Caballero-Mora, B. Caccianiga, L. Caramete, R. Caruso, A. Castellina, O. Catalano, G. Cataldi, L. Cazon, R. Cester, J. Chauvin, S. H. Cheng, A. Chiavassa, J. A. Chinellato, J. Chirinos Diaz, J. Chudoba, M. Cilmo, R. W. Clay, M. R. Coluccia, R. Conceição, F. Contreras, H. Cook, M. J. Cooper, J. Coppens, A. Cordier, S. Coutu, C. E. Covault, A. Creusot, A. Criss, J. Cronin, A. Curutiu, S. Dagoret-Campagne, R. Dallier, B. Daniel, S. Dasso, K. Daumiller, B. R. Dawson, R. M. de Almeida, M. De Domenico, C. De Donato, S. J. de Jong, G. De La Vega, W. J. M. de Mello Junior, J. R. T. de Mello Neto, I. De Mitri, V. de Souza, K. D. de Vries, L. del Peral, M. del Río, O. Deligny, H. Dembinski, N. Dhital, C. Di Giulio, M. L. Díaz Castro, P. N. Diep, F. Diogo, C. Dobrigkeit, W. Docters, J. C. D'Olivo, P. N. Dong, A. Dorofeev, J. C. dos Anjos, M. T. Dova, D. D'Urso, I. Dutan, J. Ebr, R. Engel, M. Erdmann, C. O. Escobar, J. Espadanal, A. Etchegoyen, P. Facal San Luis, H. Falcke, G. Farrar, A. C. Fauth, N. Fazzini, A. P. Ferguson, B. Fick, A. Filevich, A. Filipčič, S. Fliescher, C. E. Fracchiolla, E. D. Fraenkel, O. Fratu, U. Fröhlich, B. Fuchs, R. Gaior, R. F. Gamarra, S. Gambetta, B. García, S. T. Garcia Roca, D. Garcia-Gamez, D. Garcia-Pinto, A. Gascon Bravo, H. Gemmeke, P. L. Ghia, M. Giller, J. Gitto, H. Glass, M. S. Gold, G. Golup, F. Gomez Albarracin, M. Gómez Berisso, P. F. Gómez Vitale, P. Gonçalves, J. G. Gonzalez, B. Gookin, A. Gorgi, P. Gouffon, E. Grashorn, S. Grebe, N. Griffith, M. Grigat, A. F. Grillo, Y. Guardincerri, F. Guarino, G. P. Guedes, P. Hansen, D. Harari, T. A. Harrison, J. L. Harton, A. Haungs, T. Hebbeker, D. Heck, A. E. Herve, C. Hojvat, N. Hollon, V. C. Holmes, P. Homola, J. R. Hörandel, P. Horvath, M. Hrabovský, D. Huber, T. Huege, A. Insolia, F. Ionita, A. Italiano, C. Jarne, S. Jiraskova, M. Josebachuili, K. Kadija, K. H. Kampert, P. Karhan, P. Kasper, I. Katkov, B. Kégl, B. Keilhauer, A. Keivani, J. L. Kelley, E. Kemp, R. M. Kieckhafer, H. O. Klages, M. Kleifges, J. Kleinfeller, J. Knapp, D.-H. Koang, K. Kotera, N. Krohm, O. Krömer, D. Kruppke-Hansen, F. Kuehn, D. Kuempel, J. K. Kulbartz, N. Kunka, G. La Rosa, C. Lachaud, D. LaHurd, L. Latronico, R. Lauer, P. Lautridou, S. Le Coz, M. S. A. B. Leão, D. Lebrun, P. Lebrun, M. A. Leigui de Oliveira, A. Letessier-Selvon, I. Lhenry-Yvon, K. Link, R. López, A. Lopez Agüera, K. Louedec, J. Lozano Bahilo, L. Lu, A. Lucero, M. Ludwig, H. Lyberis, M. C. Maccarone, C. Macolino, S. Maldera, D. Mandat, P. Mantsch, A. G. Mariazzi, J. Marin, V. Marin, I. C. Maris, H. R. Marquez Falcon, G. Marsella, D. Martello, L. Martin, H. Martinez, O. Martínez Bravo, H. J. Mathes, J. Matthews, J. A. J. Matthews, G. Matthiae, D. Maurel, D. Maurizio, P. O. Mazur, G. Medina-Tanco, M. Melissas, D. Melo, E. Menichetti, A. Menshikov, P. Mertsch, C. Meurer, S. Mićanović, M. I. Micheletti, I. A. Minaya, L. Miramonti, L. Molina-Bueno, S. Mollerach, M. Monasor, D. Monnier Ragaigne, F. Montanet, B. Morales, C. Morello, E. Moreno, J. C. Moreno, M. Mostafá, C. A. Moura, M. A. Muller, G. Müller, M. Münchmeyer, R. Mussa, G. Navarra, J. L. Navarro, S. Navas, P. Necesal, L. Nellen, A. Nelles, J. Neuser, P. T. Nhung, M. Niechciol, L. Niemietz, N. Nierstenhoefer, D. Nitz, D. Nosek, L. Nožka, J. Oehlschläger, A. Olinto, M. Ortiz, N. Pacheco, D. Pakk Selmi-Dei, M. Palatka, J. Pallotta, N. Palmieri, G. Parente, E. Parizot, A. Parra, S. Pastor, T. Paul, M. Pech, J. Pękala, R. Pelayo, I. M. Pepe, L. Perrone, R. Pesce, E. Petermann, S. Petrera, A. Petrolini, Y. Petrov, C. Pfendner, R. Piegaia, T. Pierog, P. Pieroni, M. Pimenta, V. Pirronello, M. Platino, M. Plum, V. H. Ponce, M. Pontz, A. Porcelli, P. Privitera, M. Prouza, E. J. Quel, S. Querchfeld, J. Rautenberg, O. Ravel, D. Ravignani, B. Revenu, J. Ridky, S. Riggi, M. Risse, P. Ristori, H. Rivera, V. Rizi, J. Roberts, W. Rodrigues de Carvalho, G. Rodriguez, I. Rodriguez Cabo, J. Rodriguez Martino, J. Rodriguez Rojo, M. D. Rodríguez-Frías, G. Ros, J. Rosado, T. Rossler, M. Roth, B. Rouillé-d'Orfeuil, E. Roulet, A. C. Rovero, C. Rühle, A. Saftoiu, F. Salamida, H. Salazar, F. Salesa Greus, G. Salina, F. Sánchez, C. E. Santo, E. Santos, E. M. Santos, F. Sarazin, B. Sarkar, S. Sarkar, R. Sato, N. Scharf, V. Scherini, H. Schieler, P. Schiffer, A. Schmidt, O. Scholten, H. Schoorlemmer, J. Schovancova, P. Schovánek, F. Schröder, S. Schulte, D. Schuster, S. J. Sciutto, M. Scuderi, A. Segreto, M. Settimo, A. Shadkam, R. C. Shellard, I. Sidelnik, G. Sigl, O. Sima, A. Śmiałkowski, R. Šmída, G. R. Snow, P. Sommers, J. Sorokin, H. Spinka, R. Squartini, Y. N. Srivastava, S. Stanic, J. Stapleton, J. Stasielak, M. Stephan, A. Stutz, F. Suarez, T. Suomijärvi, A. D. Supanitsky, T. Šuša, M. S. Sutherland, J. Swain, Z. Szadkowski, M. Szuba, A. Tapia, M. Tartare, O. Taşcău, R. Tcaciuc, N. T. Thao, D. Thomas, J. Tiffenberg, C. Timmermans, W. Tkaczyk, C. J. Todero Peixoto, G. Toma, L. Tomankova, B. Tomé, A. Tonachini, P. Travnicek, D. B. Tridapalli, G. Tristram, E. Trovato, M. Tueros, R. Ulrich, M. Unger, M. Urban, J. F. Valdés Galicia, I. Valiño, L. Valore, A. M. van den Berg, E. Varela, B. Vargas Cárdenas, J. R. Vázquez, R. A. Vázquez, D. Veberič, V. Verzi, J. Vicha, M. Videla, L. Villaseñor, H. Wahlberg, P. Wahrlich, O. Wainberg, D. Walz, A. A. Watson, M. Weber, K. Weidenhaupt, A. Weindl, F. Werner, S. Westerhoff, B. J. Whelan, A. Widom, G. Wieczorek, L. Wiencke, B. Wilczyñska, H. Wilczyñski, M. Will, C. Williams, T. Winchen, M. Wommer, B. Wundheiler, T. Yamamoto, T. Yapici, P. Younk, G. Yuan, A. Yushkov, B. Zamorano Garcia, E. Zas, D. Zavrtanik, M. Zavrtanik, I. Zaw, A. Zepeda, Y. Zhu, M. Zimbres Silva, and M. Ziolkowski
Subjects: Physics, QC1-999
Abstract: The observation of ultrahigh energy neutrinos (UHEνs) has become a priority in experimental astroparticle physics. UHEνs can be detected with a variety of techniques. In particular, neutrinos can interact in the atmosphere (downward-going ν) or in the Earth crust (Earth-skimming ν), producing air showers that can be observed with arrays of detectors at the ground. With the surface detector array of the Pierre Auger Observatory we can detect these types of cascades. The distinguishing signature for neutrino events is the presence of very inclined showers produced close to the ground (i.e., after having traversed a large amount of atmosphere). In this work we review the procedure and criteria established to search for UHEνs in the data collected with the ground array of the Pierre Auger Observatory. This includes Earth-skimming as well as downward-going neutrinos. No neutrino candidates have been found, which allows us to place competitive limits to the diffuse flux of UHEνs in the EeV range and above.
Published: 2013
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43. On-sky measurements of atmospheric dispersion: I. Method validation

Author: G. Avila, Alexandre Cabral, and Bachar Wehbe
Subjects: media_common.quotation_subject, FOS: Physical sciences, Astrophysics::Cosmology and Extragalactic Astrophysics, 01 natural sciences, 010309 optics, 0103 physical sciences, Dispersion (optics), Range (statistics), Astrophysics::Solar and Stellar Astrophysics, 010303 astronomy & astrophysics, Spectrograph, Instrumentation and Methods for Astrophysics (astro-ph.IM), Astrophysics::Galaxy Astrophysics, media_common, Remote sensing, Physics, Atmospheric models, Astrophysics::Instrumentation and Methods for Astrophysics, Astronomy and Astrophysics, Atmospheric dispersion modeling, Radial velocity, Wavelength, Space and Planetary Science, Sky, Astrophysics::Earth and Planetary Astrophysics, Astrophysics - Instrumentation and Methods for Astrophysics
Abstract: Observations with ground-based telescopes are affected by differential atmospheric dispersion due to the wavelength-dependent index of refraction of the atmosphere. The usage of an Atmospheric Dispersion Corrector (ADC) is fundamental to compensate this effect. Atmospheric dispersion correction residuals above the level of ~ 100 milli-arcseconds (mas) will affect astronomical observations, in particular radial velocity and flux losses. The design of an ADC is based on atmospheric models. To the best of our knowledge, those models have never been tested on-sky. In this paper, we present a new method to measure the atmospheric dispersion on-sky in the optical range. We require an accuracy better than 50 mas that is equal to the difference between atmospheric models. The method is based on the use of cross-dispersion spectrographs to determine the position of the centroid of the spatial profile at each wavelength of each spectral order. The method is validated using cross-dispersed spectroscopic data acquired with the slit spectrograph UVES. We measure an instrumental dispersion of 47 mas in the blue arm, 15 mas, and 23 mas in the two ranges of the red arm. We also measure a 4 % deviation in the pixel scale from the value cited in UVES manual. The accuracy of the method is ~ 17 mas in the range of 315-665 nm. At this level, we can compare and characterize different atmospheric dispersion models for better future ADC designs., Accepted for publication in MNRAS
Published: 2020

44. Caregivers' evaluation of an educational material targeted to children with hydrocephalus

Author: P A, Caus, P T, Hamamoto Filho, and M A G, Avila
Subjects: Caregivers, Health Personnel, Surveys and Questionnaires, Humans, Child, Hydrocephalus
Abstract: Modern pediatric neurosurgery succeeded in reducing ventricle-peritoneal shunt malfunctions and shunt revisions. However, some children may be submitted to many surgeries, posing burden to their caregivers. And most of caregiver assume responsibility for care without emotional preparation. It is up to health professionals to carry out the educational process. The aim of this study was to evaluate the knowledge, attitude, and practice of informal caregivers of children with hydrocephalus before and after intervention with previously developed educational material.This is a quasi-experimental, before-and-after study conducted with 32 informal caregivers of children with hydrocephalus. Data collection occurred in three stages: pre-test, educational intervention through educational material, and post-test. The knowledge, attitude, and practice survey was used as a pre-test and post-test assessment tool.The mean score in the three domains (knowledge, attitude, and practice) was lower in the pre-test compared to the post-test. After caregivers read the educational material, the correct answer rate increased by 17% in the knowledge domain and 21.4% in the practice domain, with p values of0.01. In the attitude domain, there was a non-significant increase of 0.06 (2.0%, p = 0.161) points in the mean score between the pre-test and the post-test.The educational material enables the acquisition of knowledge of informal caregivers of children with hydrocephalus. This can be used by health professionals to strengthen the bond between professional care staff and family, and to facilitate the educational process.
Published: 2020

45. EuroGuiDerm Guideline on the systemic treatment of Psoriasis vulgaris - Part 1: treatment and monitoring recommendations

Author: P.G. Sator, Ulrich Mrowietz, Ph.I. Spuls, D. Kaur-Knudsen, Alexander Nast, Zsuzsanna Bata-Csorgo, G. E. van der Kraaij, Éva Remenyik, H Boonen, Catherine H. Smith, Julia-Tatjana Maul, Satveer K. Mahil, O. Sundnes, T. Malkonen, Kristian Reich, Marcus Schmitt-Egenolf, S. Mburu, Mariusz Sikora, E.M.G.J. de Jong, D. Trigos, Paolo Gisondi, Ignacio García-Doval, Nikhil Yawalkar, Klaus Strömer, Corinna Dressler, K.M. Ronholt, G. Avila Valle, Department of Dermatology, Allergology and Venereology, Helsinki University Hospital Area, Dermatology, AII - Inflammatory diseases, APH - Methodology, APH - Quality of Care, Experimental Immunology, Graduate School, and APH - Personalized Medicine
Subjects: EUROPEAN ACADEMY, medicine.medical_specialty, education, Brodalumab, S2K GUIDELINE, Dermatology, Severity of Illness Index, Etanercept, HERPES-ZOSTER, 030207 dermatology & venereal diseases, 03 medical and health sciences, 0302 clinical medicine, Ustekinumab, medicine, Humans, Psoriasis, SYSTEMIC TREATMENT, Dermatologi och venereologi, 030212 general & internal medicine, Certolizumab pegol, Intensive care medicine, Risankizumab, business.industry, LONG-TERM SAFETY, Adalimumab, LIFE QUALITY INDEX, Guideline, SEVERE PLAQUE PSORIASIS, Infliximab, RHEUMATOID-ARTHRITIS, 3. Good health, Dermatology and Venereal Diseases, Ixekizumab, Infectious Diseases, 3121 General medicine, internal medicine and other clinical medicine, Inflammatory diseases Radboud Institute for Health Sciences [Radboudumc 5], ANTITUMOR NECROSIS FACTOR, Secukinumab, business, CLINICAL-TRIALS, medicine.drug
Abstract: Contains fulltext : 229416.pdf (Publisher’s version ) (Open Access) This evidence- and consensus-based guideline on the treatment of psoriasis vulgaris was developed following the EuroGuiDerm Guideline and Consensus Statement Development Manual. The first part of the guideline includes general information on the scope and purpose, health questions covered, target users and strength/limitations of the guideline. Suggestions for disease severity grading and treatment goals are provided. It presents the general treatment recommendations as well as detailed management and monitoring recommendations for the individual drugs. The treatment options discussed in this guideline are as follows: acitretin, ciclosporin, fumarates, methotrexate, adalimumab, apremilast, brodalumab, certolizumab pegol, etanercept, guselkumab, infliximab, ixekizumab, risankizumab, secukinumab, tildrakizumab and ustekinumab.
Published: 2020

46. DS_10.1177_0022034520905660 – Supplemental material for Efficacy of Alveolar Ridge Preservation: A Randomized Controlled Trial

Author: G. Avila-Ortiz, M. Gubler, M. Romero-Bustillos, C.L. Nicholas, M.B. Zimmerman, and C.A. Barwacz
Subjects: 110599 Dentistry not elsewhere classified, FOS: Materials engineering, FOS: Clinical medicine, 91299 Materials Engineering not elsewhere classified
Abstract: Supplemental material, DS_10.1177_0022034520905660 for Efficacy of Alveolar Ridge Preservation: A Randomized Controlled Trial by G. Avila-Ortiz, M. Gubler, M. Romero-Bustillos, C.L. Nicholas, M.B. Zimmerman and C.A. Barwacz in Journal of Dental Research
Published: 2020
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47. A precise architecture characterization of the π Mensae planetary system

Author: Giorgio Pariani, A. Fragoso, Andrea Modigliani, Paolo Molaro, Yann Alibert, Jose Luis Rasilla, Giuseppina Micela, S. Santana Tschudi, David Ehrenreich, Antonino Bianco, Paolo Conconi, Hans Dekker, P. Figueira, Denis Mégevand, Luca Pasquini, Matteo Aliverti, B. Delabre, Filippo Maria Zerbi, T. Bandy, M. A. Monteiro, E. Mueller, R. Génova Santos, C. Maire, A. Suárez Mascareño, Edoardo Maria Alberto Redaelli, Manuel Abreu, Giorgio Calderone, Luca Oggioni, G. Avila, C. Allende Prieto, L. Genolet, Mahmoudreza Oshagh, Nelson J. Nunes, M. Affolter, Stéphane Udry, Vardan Adibekyan, Ennio Poretti, Alessandro Sozzetti, G. Lo Curto, David Alves, Danuta Sosnowska, Alexandre Cabral, Andrea Mehner, J. Knudstrup, Romain Allart, F. Tenegi, Nuno C. Santos, Stefano Cristiani, Marco Riva, Florian Kerber, José Manuel Rebordão, Rafael Rebolo, Olivier Demangeon, C. Lovis, Enric Palle, Damien Ségransan, I. Hughes, Mário J. P. F. G. Monteiro, Vincent Bourrier, J. I. González Hernández, G. Cupani, M. Amate, J. L. Lizon, Roberto Cirami, M. R. Zapatero Osorio, Antonio Gouveia Oliveira, Paolo Santin, João P. Faria, François Bouchy, Baptiste Lavie, S. G. Sousa, Hugo M. Tabernero, Willy Benz, D. Álvarez, Francesco Borsa, T. M. Schmidt, P. Di Marcantonio, Diego Bossini, Francesco Pepe, P. Spano, Pedro Santos, Marco Landoni, S. C. C. Barros, Xavier Dumusque, Olaf Iwert, Cristina Martins, Michael T. Murphy, V. Baldini, C. Broeg, Matteo Genoni, Claudio Cumani, A. Segovia, M. Moschetti, João Coelho, Valentina D'Odorico, Alessio Zanutta, S. Deiries, Igor Coretti, Jorge Lillo-Box, Mario Damasso, Unidad de Excelencia Científica María de Maeztu Centro de Astrobiología del Instituto Nacional de Técnica Aeroespacial y CSIC, MDM-2017-0737, Swiss National Science Foundation (SNSF), Agenzia Spaziale Italiana (ASI), Fundação para a Ciência e a Tecnologia (FCT), Australian Research Council (ARC), Istituto Nazionale Astrofisica (INAF), Pallé, E. [0000-0003-0987-1593], Progetto Premiale 2015 FRONTIERA funding scheme of the Italian Ministry of Education University and Research, ESPRESSO through the SNSF 140649 152721 166227 184618 University and Research OB.FU. 1.05.06.11, SNSF's FLARE Programme, FEDER through COMPETE2020 -Programa Operacional Competitividade e Internacionalizacao UID/FIS/04434/2019 UIDB/04434/2020 UIDP/04434/2020 PTDC/FIS-AST/32113/2017 POCI-01-0145-FEDER-032113 PTDC/FIS-AST/28953/2017 POCI-01-0145-FEDER-028953 PTDC/FIS-AST/28987/2017 POCI-01-0145-FEDER-028987, Fundação para a Ciência e a Tecnologia (FCT) IF/01312/2014/CP1215/CT0004 IF/00650/2015/CP1273/CT0001 IF/00028/2014/CP1215/CT0002 DL 57/2016/CP1364/CT0005, Spanish Government, Ministerio de Ciencia e Innovación (MICINN) under the 2013 Ramon y Cajal program RYC-2013-14875, Australian Research Council, Istituto Nazionale Astrofisica (INAF) Agenzia Spaziale Italiana (ASI) n.2018-16-HH.0, and Unidad de Excelencia María de Maeztu Centro de Astrobiología del Instituto Nacional de Técnica Aeroespacial y CSIC
Subjects: Orbital plane, Brown dwarf, Orbital eccentricity, Context (language use), Astrophysics, 01 natural sciences, Planet, pi Men, individual: π Men [Stars], 0103 physical sciences, Astrophysics::Solar and Stellar Astrophysics, 010303 astronomy & astrophysics, Astrophysics::Galaxy Astrophysics, Physics, Stars: individual: π Men, radial velocities [Techniques], 010308 nuclear & particles physics, photometric [Techniques], individual: [stars], Astronomy and Astrophysics, Astrometry, Planetary system, Radial velocity, Planetary systems, Astrophysics - Solar and Stellar Astrophysics, 13. Climate action, Space and Planetary Science, Techniques: radial velocities, Astrophysics::Earth and Planetary Astrophysics, Techniques: photometric, Astrophysics - Earth and Planetary Astrophysics
Abstract: Damasso, M. et al., Context. The bright star π Men was chosen as the first target for a radial velocity follow-up to test the performance of ESPRESSO, the new high-resolution spectrograph at the European Southern Observatory's Very Large Telescope. The star hosts a multi-planet system (a transiting 4 M· planet at ∼0.07 au and a sub-stellar companion on a ∼2100-day eccentric orbit), which is particularly suitable for a precise multi-technique characterization. Aims. With the new ESPRESSO observations, which cover a time span of 200 days, we aim to improve the precision and accuracy of the planet parameters and search for additional low-mass companions. We also take advantage of the new photometric transits of π Men c observed by TESS over a time span that overlaps with that of the ESPRESSO follow-up campaign. Methods. We analysed the enlarged spectroscopic and photometric datasets and compared the results to those in the literature. We further characterized the system by means of absolute astrometry with HIPPARCOS and Gaia. We used the high-resolution spectra of ESPRESSO for an independent determination of the stellar fundamental parameters. Results. We present a precise characterization of the planetary system around π Men. The ESPRESSO radial velocities alone (37 nightly binned data with typical uncertainty of 10 cm s-1) allow for a precise retrieval of the Doppler signal induced by π Men c. The residuals show a root mean square of 1.2 m s-1, which is half that of the HARPS data; based on the residuals, we put limits on the presence of additional low-mass planets (e.g. we can exclude companions with a minimum mass less than ∼2 M· within the orbit of π Men c). We improve the ephemeris of π Men c using 18 additional TESS transits, and, in combination with the astrometric measurements, we determine the inclination of the orbital plane of π Men b with high precision (ib =45.8-1.1+1.4 deg). This leads to the precise measurement of its absolute mass mb =14.1-0.4+0.5 MJup, indicating that π Men b can be classified as a brown dwarf. Conclusions. The π Men system represents a nice example of the extreme precision radial velocities that can be obtained with ESPRESSO for bright targets. Our determination of the 3D architecture of the π Men planetary system and the high relative misalignment of the planetary orbital planes put constraints on and challenge the theories of the formation and dynamical evolution of planetary systems. The accurate measurement of the mass of π Men b contributes to make the brown dwarf desert a bit greener., With funding from the Spanish government through the "María de Maeztu Unit of Excellence" accreditation (MDM-2017-0737)
Published: 2020

48. EuroGuiDerm Guideline on the systemic treatment of Psoriasis vulgaris - Part 1: treatment and monitoring recommendations

Author: Nast, A., Smith, C., Spuls, P.I., Valle, G. Avila, Bata-Csorgo, Z., Boonen, H., Jong, E.M.G.J. de, Garcia-Doval, I., Gisondi, P., Kaur-Knudsen, D., Mahil, S., Malkonen, T., Maul, J.T., Mburu, S., Mrowietz, U., Reich, K., Remenyik, E., Ronholt, K.M., Sator, P.G., Schmitt-Egenolf, M., Sikora, M., Stromer, K., Sundnes, O., Trigos, D., Kraaij, G. van der, Yawalkar, N., Dressler, C., Nast, A., Smith, C., Spuls, P.I., Valle, G. Avila, Bata-Csorgo, Z., Boonen, H., Jong, E.M.G.J. de, Garcia-Doval, I., Gisondi, P., Kaur-Knudsen, D., Mahil, S., Malkonen, T., Maul, J.T., Mburu, S., Mrowietz, U., Reich, K., Remenyik, E., Ronholt, K.M., Sator, P.G., Schmitt-Egenolf, M., Sikora, M., Stromer, K., Sundnes, O., Trigos, D., Kraaij, G. van der, Yawalkar, N., and Dressler, C.
Abstract: Contains fulltext : 229416.pdf (Publisher’s version ) (Open Access), This evidence- and consensus-based guideline on the treatment of psoriasis vulgaris was developed following the EuroGuiDerm Guideline and Consensus Statement Development Manual. The first part of the guideline includes general information on the scope and purpose, health questions covered, target users and strength/limitations of the guideline. Suggestions for disease severity grading and treatment goals are provided. It presents the general treatment recommendations as well as detailed management and monitoring recommendations for the individual drugs. The treatment options discussed in this guideline are as follows: acitretin, ciclosporin, fumarates, methotrexate, adalimumab, apremilast, brodalumab, certolizumab pegol, etanercept, guselkumab, infliximab, ixekizumab, risankizumab, secukinumab, tildrakizumab and ustekinumab.
Published: 2020

49. An Optimal Protocol to Analyze the Rat Spinal Cord Proteome

Author: F. Gil-Dones, S. Alonso-Orgaz, G. Avila, T. Martin-Rojas, V. Moral-Darde, G. Barroso, F. Vivanco, J. Scott-Taylor, and M.G. Barderas
Subjects: Medicine (General), R5-920
Abstract: Since the function of the spinal cord depends on the proteins found there, better defing the normal Spinal Cord Proteome is an important and challenging task. Although brain and cerebrospinal fluid samples from patients with different central nervous system (CNS) disorders have been studied, a thorough examination of specific spinal cord proteins and the changes induced by injury or associated to conditions such as neurodegeneration, spasticity and neuropathies has yet to be performed. In the present study, we aimed to describe total protein content in the spinal cord of healthy rats, employing different proteomics tools. Accordingly, we have developed a fast, easy, and reproducible sequential protocol for protein extraction from rat spinal cords. We employed conventional two dimensional electrophoresis (2DE) in different pH ranges (eg. 4–7, 3–11 NL) combined with identification by mass spectrometry (MALDI-TOF/TOF), as well as first dimension protein separation combined with Liquid Chromatography Mass Spectrometry/Mass Spectrometry (LC-MS/MS) to maximise the benefits of this technology. The value of these techniques is demonstrated here by the identification of several proteins known to be associated with neuroglial structures, neurotransmission, cell survival and nerve growth in the central nervous system. Furthermore this study identified many spinal proteins that have not previously been described in the literature and which may play an important role as either sensitive biomarkers of dysfunction or of recovery after Spinal Cord Injury.
Published: 2009
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50. Reduction of dopaminergic transmission in the globus pallidus increases anxiety-like behavior without altering motor activity

Author: G, Avila, primary, O, Picazo, additional, E, Chuc-Meza, additional, and M, García-Ramirez, additional
Published: 2020
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