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5 results on '"G D Musters"'

1. Identification of the optimal treatment strategy for complex appendicitis in the paediatric population: a protocol for a multicentre prospective cohort study (CAPP study)

Author

H J Bonjer, Johanna H van der Lee, Roel Bakx, Ramon R Gorter, J Berkhof, J Jansen, T Wagner, J W A Oosterhuis, R R van Rijn, F C van Eijck, A Jairam, P van Duijvendijk, V B Nieuwenhuijs, Paul van Amstel, Marijke C van der Weide, Rik van Eekelen, Joep P M Derikx, Ernest L W van Heurn, H A Rippen, B G P Koot, M van der Kuip, M A Lijkwan, P Boele van Hensbroek, M Springer, M D P Luyer, L M de Widt, M Knaapen, C M G Keyzer-Dekker, R Wijnen, G M P Diepenhorst, K M A Dreuning, M M Poelman, D Verver, M E van der Sande, G W Zijp, E H Pasveer, R P R Groenendijk, J L A van Vugt, W J Vles, C A Selles, J T Hoffman, J W A Leijtens, E G M Vosbeek, C C van Rossem, M P Gaspersz, M H M Bender, B J Corten, E C J Consten, M F J Seesing, T S Bijlsma, S M L The, L E Janssen, V J Leijdekkers, M V Nijenhuis, S M B I Botden, M Joosten, A L A Bloemendaal, C F J M Blanken-Peeters, W M IJgosse, A Meij-de Vries, M M Bruntink, P M N Y H Go, M Pool, S J Oosterling, T C Derksen, A A W van Geloven, T T Poels, J B F Hulscher, F C den Boer, S F Hardon, F P Garssen, M F Lutke Holzik, M B G M Decaestecker, E G Boerma, D Schweitzer, and G D Musters

Subjects
Medicine
Published
2022
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2. Identification of the optimal treatment strategy for complex appendicitis in the paediatric population

Author

Paul, van Amstel, Roel, Bakx, Johanna H, van der Lee, Marijke C, van der Weide, Rik van, Eekelen, Joep P M, Derikx, Ernest L W, van Heurn, Ramon R, Gorter, G D, Musters, Pediatric surgery, Amsterdam Reproduction & Development (AR&D), Other Research, General practice, Epidemiology and Data Science, Amsterdam Reproduction & Development, Graduate School, AGEM - Endocrinology, metabolism and nutrition, General Paediatrics, APH - Methodology, APH - Quality of Care, Amsterdam Gastroenterology Endocrinology Metabolism, and Paediatric Surgery

Subjects
Adolescent, paediatric colorectal surgery, General Medicine, Appendicitis, paediatric gastroenterology, Abscess, Treatment Outcome, Quality of Life, Appendectomy, Humans, Multicenter Studies as Topic, paediatric surgery, Prospective Studies, Child
Abstract

IntroductionIn daily practice large heterogeneity in the treatment of children with complex appendicitis exists. Complex appendicitis can be divided into two subtypes; complex appendicitis with and without appendiceal mass and/or abscess. As complex appendicitis is associated with high morbidity and costs, identification of the optimal treatment strategy is essential. In this article, we present the study protocol for the CAPP (Complex Appendicitis in the Pediatric Population) study.Methods and analysisThis nation-wide, multi-centre, comparative, non-randomised prospective cohort study includes all children Ethics and disseminationThe Medical Ethics Review Committee of the Amsterdam UMC, location AMC, declared that the Medical Research involving Human Subjects Act (WMO) did not apply to this study. Therefore, no official approval was required by national law. Study results will be presented in peer-reviewed scientific journals and at (inter)national conferences.Trial registration numbersNCT04755179; NL9371.

Published
2022

3. Additional file 1 of IMARI: multi-Interventional program for prevention and early Management of Anastomotic leakage after low anterior resection in Rectal cancer patIents: rationale and study protocol

Author

M. D. Slooter, Talboom, K., S. Sharabiany, C. P. M. Van Helsdingen, S. Van Dieren, C. Y. Ponsioen, C. Y. Nio, E. C. J. Consten, J. H. Wijsman, M. A. Boermeester, J. P. M. Derikx, G. D. Musters, W. A. Bemelman, P. J. Tanis, and R. Hompes

Subjects
Data_FILES
Abstract

Additional file 1.

Published
2020
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4. Locking Compression Plates are more difficult to remove than conventional non-locking plates

Author

K. J. Ponsen, G. D. Musters, Jan S. K. Luitse, J.C. Goslings, P. Boele van Hensbroek, Other departments, Surgery, Other Research, Emergency Department, and Amsterdam Movement Sciences

Subjects
medicine.medical_specialty, business.industry, Emergency Medicine, medicine, Mechanical engineering, Orthopedics and Sports Medicine, Surgery, Critical Care and Intensive Care Medicine, Compression (physics), business, Impression, Locking plate
Abstract

Locking Compression Plates (LCPs) have been introduced in the last decade. Clinicians have the impression that hardware removal of LCPs are more difficult and associated with more complications than conventional (non-locking) plates. Therefore, this study compares the complication rates of Locking Compression Plate (LCP) removal and conventional non-locking plate removal. Patients who underwent open reduction and internal fixation and subsequent hardware removal at the Department of Trauma Surgery at our Level 1 Trauma Centre between 1993 and 2007 were included through the hospital's information system. The primary outcome measure was the occurrence of complications during implant removal. A total of 210 patients were included. The females were significantly older than the males [median age, 51.5 vs. 42.6 years (p < 0.001)]. The median operation time of LCP removal was significantly longer than the operation time of non-locking plate removal (72 vs. 54 min, p < 0.001). In the total study population, complications during implant removal occurred in 25 patients (11.9%). The complication rate of conventional non-locking plate removal was 2.5%. The complication rate of LCP removal was significantly higher (17.7%, p = 0.001). LCP removal is associated with significantly more complications than conventional non-locking plate removal. The indication for removal of locking compression should be made cautiously, and surgical instruments for LCP removal should be optimized

Published
2012

5. IMARI: multi-Interventional program for prevention and early Management of Anastomotic leakage after low anterior resection in Rectal cancer patIents: rationale and study protocol

Author

M. D. Slooter, K. Talboom, S. Sharabiany, C. P. M. van Helsdingen, S. van Dieren, C. Y. Ponsioen, C. Y. Nio, E. C. J. Consten, J. H. Wijsman, M. A. Boermeester, J. P. M. Derikx, G. D. Musters, W. A. Bemelman, P. J. Tanis, R. Hompes, and on behalf of the IMARI-study group

Subjects
Rectal cancer, Anastomotic leakage, Total Mesorectal excision, Prevention, Anastomotic salvage, Surgery, RD1-811
Abstract

Abstract Background Anastomotic leakage (AL) is still a common and feared complication after low anterior resection (LAR) for rectal cancer. The multifactorial pathophysiology of AL and lack of standardised treatment options requires a multi-modal approach to improve long-term anastomotic integrity. The objective of the IMARI-trial is to determine whether the one-year anastomotic integrity rate in patients undergoing LAR for rectal cancer can be improved using a multi-interventional program. Methods IMARI is a multicentre prospective clinical effectiveness trial, whereby current local practice (control cohort) will be evaluated, and subsequently compared to results after implementation of the multi-interventional program (intervention cohort). Patients undergoing LAR for rectal cancer will be included. The multi-interventional program includes three preventive interventions (mechanical bowel preparation with oral antibiotics, tailored full splenic flexure mobilization and intraoperative fluorescence angiography using indocyanine green) combined with a standardised pathway for early detection and active management of AL. The primary outcome is anastomotic integrity, confirmed by CT-scan at one year postoperatively. Secondary outcomes include incidence of AL, protocol compliance and association with AL, temporary and permanent stoma rate, reintervention rate, quality of life and functional outcome. Microbiome analysis will be conducted to investigate the role of the rectal microbiome in AL. In a Dutch nationwide study, the AL rate was 20%, with anastomotic integrity of 90% after one year. Based on an expected reduction of AL due to the preventive approaches of 50%, and increase of anastomotic integrity by a standardised pathway for early detection and active management of AL, we hypothesised that the anastomotic integrity rate will increase from 90 to 97% at one year. An improvement of 7% in anastomotic integrity at one year was considered clinically relevant. A total number of 488 patients (244 per cohort) are needed to detect this difference, with 80% statistical power. Discussion The IMARI-trial is designed to evaluate whether a multi-interventional program can improve long-term anastomotic integrity after rectal cancer surgery. The uniqueness of IMARI lies in the multi-modal design that addresses the multifactorial pathophysiology for prevention, and a standardised pathway for early detection and active treatment of AL. Trial registration Trialregister.nl ( NL8261 ), January 2020.

Published
2020
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