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2. Prospective On-Treatment Dynamics of Circulating Extracellular Vesicles in the First-Line Setting of Patients With Advanced Non-small Cell Lung Cancer
- Author
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V. Gristina, U. Malapelle, N. Barraco, S. Taverna, L. Incorvaia, G. Badalamenti, V. Bazan, A. Galvano, C. Rolfo, and A. Russo
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Medicine - Published
- 2023
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3. Outcomes of gynecologic cancer surgery during the COVID-19 pandemic: an international, multicenter, prospective CovidSurg-Gynecologic Oncology Cancer study
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Nepogodiev, Dmitri, Siaw-Acheampong, Kwabena, Benson, Ruth A., Bywater, Edward, Chaudhry, Daoud, Dawson, Brett E., Evans, Jonathan P., Glasbey, James C., Gujjuri, Rohan R., Heritage, Emily, Jones, Conor S., Kamarajah, Sivesh K., Khatri, Chetan, Khaw, Rachel A., Keatley, James M., Knight, Andrew, Lawday, Samuel, Li, Elizabeth, Mann, Harvinder S., Marson, Ella J., McLean, Kenneth A., Mckay, Siobhan C., Mills, Emily C., Pellino, Gianluca, Picciochi, Maria, Taylor, Elliott H., Tiwari, Abhinav, Simoes, Joana FF., Trout, Isobel M., Venn, Mary L., Wilkin, Richard JW., Bhangu, Aneel, Abbott, Tom EF., Abukhalaf, Sadi, Adamina, Michel, Ademuyiwa, Adesoji O., Agarwal, Arnav, Akkulak, Murat, Alameer, Ehab, Alderson, Derek, Alakaloko, Felix, Albertsmeier, Markus, Alser, Osaid, Alshaar, Muhammad, Alshryda, Sattar, Arnaud, Alexis P., Augestad, Knut Magne, Ayasra, Faris, Azevedo, José, Bankhead-Kendall, Brittany K., Barlow, Emma, Beard, David, Blanco-Colino, Ruth, Brar, Amanpreet, Minaya-Bravo, Ana, Breen, Kerry A., Bretherton, Chris, Buarque, Igor Lima, Burke, Joshua, Caruana, Edward J., Chaar, Mohammad, Chakrabortee, Sohini, Christensen, Peter, Cox, Daniel, Cukier, Moises, Cunha, Miguel F., Davidson, Giana H., Desai, Anant, Di Saverio, Salomone, Drake, Thomas M., Edwards, John G., Elhadi, Muhammed, Emile, Sameh, Farik, Shebani, Fiore, Marco, Fitzgerald, J Edward, Ford, Samuel, Garmanova, Tatiana, Gallo, Gaetano, Ghosh, Dhruva, Ataíde Gomes, Gustavo Mendonça, Grecinos, Gustavo, Griffiths, Ewen A., Gruendl, Magdalena, Halkias, Constantine, Harrison, Ewen M., Hisham, Intisar, Hutchinson, Peter J., Hwang, Shelley, Isik, Arda, Jenkinson, Michael D., Jonker, Pascal, MA Kaafarani, Haytham, Keller, Debby, Kolias, Angelos, Kruijff, Schelto, Lawani, Ismail, Lederhuber, Hans, Leventoglu, Sezai, Litvin, Andrey, Loehrer, Andrew, Löffler, Markus W., Lorena, Maria Aguilera, Modolo, Maria Marta, Major, Piotr, Martin, Janet, Mashbari, Hassan N., Mazingi, Dennis, Metallidis, Symeon, Mohan, Helen M., Moore, Rachel, Moszkowicz, David, Moug, Susan, Ng-Kamstra, Joshua S., Maimbo, Mayaba, Negoi, Ionut, Niquen, Milagros, Ntirenganya, Faustin, Olivos, Maricarmen, Oussama, Kacimi, Outani, Oumaima, Parreno-Sacdalanm, Marie Dione, Pata, Francesco, Perez Rivera, Carlos Jose, Pinkney, Thomas D., van der Plas, Willemijn, Pockney, Peter, Qureshi, Ahmad, Radenkovic, Dejan, Ramos-De la Medina, Antonio, Richards, Toby, Roberts, Keith, Roslani, April C., Rutegård, Martin, Segura-Sampedro, Juan José, Santos, Irène, Satoi, Sohei, Sayyed, Raza, Schache, Andrew, Schnitzbauer, Andreas A., Seyi-Olajide, Justina O., Sharma, Neil, Shaw, Catherine A., Shaw, Richard, Shu, Sebastian, Soreide, Kjetil, Spinelli, Antonino, Stewart, Grant D., Sund, Malin, Sundar, Sudha, Tabiri, Stephen, Townend, Philip, Tsoulfas, Georgios, van Ramshorst, Gabrielle H., Vidya, Raghavan, Vimalachandran, Dale, Warren, Oliver J., Wedderburn, Duane, Wright, Naomi, Booth, Lesley, Barker, Neil, Cooke, Shirley, Doré, Suzanne, Horwood, Nigel, Runigamugabo, Emmy, Weir, Carrie Tierney, Dajti I, Albania, C, Allemand, LA, Boccalatte, M, Figari, M, Lamm, J, Larrañaga, C, Marchitelli, F, Noll, D, Odetto, M, Perrotta, J, Saadi, L, Zamora, Ballester, A.M., KE, Tapper, N, Zeff, JI, Valenzuela, C, Alurralde, J, Anastasio, Perez de Nucci A, Apas, EL, Caram, D, Eskinazi, JP, Mendoza, M, Usandivaras, R, Badra, A, Esteban, JS, García, PM, García, JI, Gerchunoff, Lucchini, S.M., NIgra, M.A., L, Vargas, T, Hovhannisyan, A, Stepanyan, CE, Vasey, EGR, Watson, C, Ip, J, Kealey, CSH, Lim, S, Sengupta, S, Ward, E, Wong, T, Gould, R, Gourlay, B, Griffiths, S, Gananadha, M, McLaren, J, Cecire, N, Joshi, S, Salindera, A, Sutherland, JH, Ahn, G, Charlton, S, Chen, N, Gauri, R, Hayhurst, S, Jang, F, Jia, C, Mulligan, W, Yang, G, Ye, H, Zhang, M, Ballal, D, Gibson, D, Hayne, H, McMillan, J, Moss, MJ, Pugliese, T, Richards, YTN, Seow, A, Thian, P, Viswambaram, UG, Vo, J, Bennetts, T, Bright, Brooke-Smith, M., R, Fong, B, Gricks, L, Huang, YH, Lam, A, Nathan, Ong, B.S., E, Ooi, M, Szpytma, D, Watson, K, Bagraith, S, Caird, E, Chan, C, Dawson, D, Ho, N, Hui, S, Izwan, E, Jeyarajan, S, Jordan, R, Liang, A, Lim, GJ, Nolan, A, Oar, D, Parker, H, Puhalla, A, Quennell, L, Rutherford, C, Sommerville, P, Townend, Papen M, Von, M, Wullschleger, AC, Dawson, A, Drane, A, Blatt, D, Cope, N, Egoroff, M, Fenton, J, Gani, N, Lott, P, Pockney, N, Shugg, M, Elliott, D, Phung, D, Phan, D, Townend, C, Bong, J, Gundara, A, Frankel, S, Bowman, GR, Guerra, N, Gerns, S, McGeorge, A, Riddell, M, Roberts, N, Rukin, J, Bolt, K, Buddingh, Dudi-Venkata, N.N., S, Jog, HM, Kroon, T, Sammour, R, Smith, C, Stranz, M, Batstone, K, Lah, W, McGahan, D, Mitchell, A, Morton, A, Pearce, G, Sheahan, B, Swinson, A, Waldron, P, Walker, N, Alam, S, Banting, L, Chong, P, Choong, S, Clatworthy, D, Foley, A, Fox, MW, Hii, B, Knowles, J, Mack, M, Read, A, Rowcroft, G, Wright, EWY, Lun, M, Lanner, J, Burtscher, Trivik-Barrientos, F., I, Königsrainer, M, Bauer, C, Freyschlag, M, Kafka, F, Messner, D, Öfner, I, Tsibulak, S, Holawe, M, Zimmermann, K, Emmanuel, M, Grechenig, R, Gruber, M, Harald, L, Öhlberger, J, Presl, A, Wimmer, İ, Namazov, E, Samadov, D, Barker, R, Boyce, S, Corbin, A, Doyle, A, Eastmond, R, Gill, A, Haynes, S, Millar, M, O’Shea, G, Padmore, N, Paquette, E, Phillips, John S, St., K, Walkes, J, Abeloos, Backer T, De, Ceulaer J, De, C, Dick, Diez-Fraile, A., P, Lamoral, C, Spaas, W, Ceelen, P, Pattyn, D, Van de putte, Nieuwenhove Y, Van, Ramshorst G, Van, Willaert, W., Bazzett-Matabele, L., SP, Chiyapo, Ramogola-Masire, D., G, Ramontshonyana, A, Seiphetlheng, P, Vuylsteke, EA, Abdallah, Júnior S, Aguiar, G, Baiocchi, GB, Carvalho, FJF, Coimbra, LP, Kowalski, F, Makdissi, N, Marques, T, Marques, Santos S, Soares Dos, Gonçalves B, Tirapelli, JG, Vartanian, Reis R, Dos, P, Camara, Lima RK, De, Giustina E, Della, PV, Hoffmann, A, Gatti, C, Nardi, R, Oliva, L, Nacif, Ferro C, Carvalho, Ataíde G, Gomes Mendonça, Buarque I, Lima, A, Lira dos Santos Leite, Pol-Fachin, L., Bezerra T, Santos, Ramos da Silva A, Maylson, de Araújo Silvestre D, Windson, Barros A, Vieira, L, Campbell, Cicco R, De, I, Cecconello, P, Gregorio, Lima L, Pontual, Junior U, Ribeiro, FR, Takeda, RM, Terra, Teixeira M, Faccini, Kulcsar, M.A.V., LL, Matos, KS, Nunes, G, Laporte, M, Salem, Awada J, Barakat, TR, Ijichi, NJ, Kim, A, Marreiro, B, Muller, R, Nunes, B, Bodanese, ER, Eidt, JC, Isoton, Vieira da Cunha M, Lemos, de Sampaio L, Regina, C, Vendrame, M, Zeni, JA, Zortéa, MR, Zortéa, M, Sokolov, B, Kidane, S, Srinathan, A, Munro, L, Helyer, D, McKeen, M, Boutros, NG, Caminsky, G, Ghitulescu, G, Jamjoum, J, Moon, J, Pelletier, T, Vanounou, S, Wong, D, Cheng, SD, MacNeil, J, Martin, S, Dumitra, A, Kouyoumdjian, S, Schmid, J, Spicer, A, Agarwal, A, Brar, J, Dada, A, Dare, U, Hameed, F, Osman, B, Johnston, C, Russell, G, Groot, A, Persad, H, Pham, M, Wood, M, Ko, L, Rajendran, S, Demyttenaere, R, Garfinkle, C, Brown, A, Karimuddin, N, Lee, J, Liu, Kia T, Madani, Phang, P.T., M, Raval, K, Tom, Abou-Khalil, J., A, Martel, C, Nessim, J, Stevenson, Riyami S, Al, K, Bali, D, Bigam, K, Dajani, A, Dell, MM, Modolo, Nieto P, Ramirez, R, Sepulveda, A, Molero, A, Bolbaran, I, Ruiz, F, Heredia, F, Bellolio, N, Besser, E, Grasset, JO, Guaman, M, Inzunza, MJ, Irarrázaval, C, Jarry, Martinic M, Quintana, Altamirano C, Riquoir, Manqui CA, Romero, Esquide M, Ruiz, Añazco C, Vargas, A, Almeciga, A, Fletcher, A, Merchan, T, Quijano, D, Sanabria, Arias-Amézquita, F., C, Cétares, Murgueitio N, Cortes, Gomez-Mayorga, J.L., Herrera-Almario, G., J, Rodriguez, P, Iglesias, LO, Puentes, JA, Calvache, Orozco-Chamorro, C.M., DA, Rojas, Sánchez-Gómez, A., M, Abadia, J, Acosta, Aristizabal J, Angel, A, Bonilla, L, Caicedo, Quiroz PH, Calderon, Bonilla S, Cervera, S, Diaz, H, Facundo, Mora M, Garcia, O, Guevara, L, Guzman, Mora DR, Herrera, Ramirez LJ, Jimenez, C, Lehmann, E, Manrique, I, Mariño, M, Medina, Morales RE, Pinilla, A, Puerto, Horta J, Puerto, M, Quintero, Ferro M, Rey, A, Saénz, D, Santana, W, Serrano, O, Suescun, Sanchez LM, Trujillo, Cuasquen BG, Velasquez, Quevedo J , Bogota, Mendoza, G, Bačić, D, Karlović, D, Kršul, M, Zelić, I, Luksic, M, Mamic, I, Bacic, B, Bakmaz, I, Ćoza, E, Dijan, Z, Katusic, J, Mihanovic, D, Morović, I, Rakvin, H, Almezghwi, K, Arslan, H, Besim, A, Özant, N, Özçay, K, Frantzeskou, N, Gouvas, G, Kokkinos, P, Papatheodorou, I, Pozotou, O, Stavrinidou, A, Yiallourou, L, Martinek, M, Skrovina, M, Straka, I, Szubota, M, Peteja, J, Žatecký, V, Javurkova, J, Klat, S, Antony, T, Avlund, KD, Berg, M, Borre, P, Christensen, MC, Elkjær, A, Ernst, SK, Fensman, M, Haldrup, JL, Harbjerg, LH, Iversen, Jensen, P.T., TD, Jeppesen, DW, Kjaer, HØ, Kristensen, N, Lund, Axelsen S, Maigaard, M, Mekhael, N, Mikic, EB, Ostenfeld, AL, Ebbehøj, P, Krarup, N, Schlesinger, H, Smith, S, Batista, A, Crespo, PJ, Díaz, R, Rivas, Rodriguez-Abreu, J., N, Tactuk, Kassas M, El, W, Omar, A, Tawheed, M, Talaat, A, Abdelsamed, AY, Azzam, H, Salem, A, Seleim, A, Abdelmajeed, M, Abdou, NE, Abosamak, Sayed M, A.L., F, Ashoush, R, Atta, E, Elazzazy, M, Elnemr, Hewalla ME, Elsayed, I, Elsherbini, E, Essam, M, Ewedah, I, Ghallab, E, Hassan, M, Ibrahim, M, Metwalli, M, Mourad, Qatora, M.S., M, Ragab, A, Sabry, H, Saifeldin, A, Samih, Abdelaal A, Samir, S, Shehata, K, Shenit, D, Attia, N, Kamal, N, Osman, Abbas, A.M., Elazeem HAS, Abd, Abd-Elkariem, A.Y., MM, Abdelkarem, S, Alaa, M, Ashraf, A, Ayman, MG, Azizeldine, H, Elkhayat, Mashhour A, Emad, M, Gaber, HM, Hamza, I, Hawal, HF, Hetta, Ali A, K., S, M.elghazaly, MM, Mohammed, FA, Monib, Nageh, M.A., A, Saad, MM, Saad, M, Shahine, EA, Yousof, A, Youssef, El-Deeb, M., M, Fawzy, G, Ghaly, M, Ibraheem, A, Eldaly, E, Esmail, M, ElFiky, A, Nabil, M, Alrahawy, A, Sakr, H, Soliman, H, Soltan, G, Amira, I, Sallam, M, Sherief, A, Sherif, A, Abdelrahman, H, Aboulkassem, R, Hamdy, A, Morsi, G, Sherif, H, Abdeldayem, Salama I, Abdelkader, M, Balabel, Y, Fayed, AE, Sherif, R, Elmorsi, S, Emile, B, Refky, S, Abd-elsalam, H, Badr, M, Elbahnasawy, M, Elzoghby, M, Essa, Badr S, Gamal, A, Ghoneim, O, Hamad, M, Hamada, M, Hammad, A, Hawila, Morsy, M.S., S, Salman, S, Sarsik, K, Bekele, JH, Kauppila, E, Sarjanoja, O, Helminen, H, Huhta, C, Beyrne, L, Jouffret, L, Lugans, Marie-Macron, L., E, Chouillard, Simone B, De, F, Fredon, A, Roux, J, Bettoni, S, Dakpé, B, Devauchelle, N, Lavagen, S, Testelin, S, Boucher, R, Breheret, A, Gueutier, A, Kahn, Kün-Darbois, J., A, Barrabe, Z, Lakkis, A, Louvrier, S, Manfredelli, P, Mathieu, A, Chebaro, V, Drubay, M, El amrani, C, Eveno, K, Lecolle, G, Legault, L, Martin, G, Piessen, FR, Pruvot, S, Truant, P, Zerbib, Q, Ballouhey, B, Barrat, L, Fourcade, J, Laloze, H, Salle, A, Taibi, J, Tricard, J, Usseglio, D, Bergeat, A, Merdrignac, Roy B, Le, LO, Perotto, A, Scalabre, H, Gornes, C, Vaysse, K, Vergriete, A, Aimé, A, Ezanno, B, Malgras, AP, Arnaud, E, Fustec, V, Lavoue, C, Tesson, P, Bouche, S, Tzedakis, E, Cotte, O, Glehen, J, Lifante, L, Bendjemar, H, Braham, L, Charre, Arbi N, El, L, Morel-chevillet, A, Police, V, Villefranque, E, Volpin, A, D’Urso, E, Felli, D, Mutter, P, Pessaux, B, Seeliger, Y, Barbé, J, Bardet, E, Barret, R, Berry, G, Boddaert, S, Bonnet, E, Brian, N, Cathala, X, Cathelineau, C, Denet, D, Fuks, D, Gossot, M, Grigoroiu, A, Laforest, Levy-Zauberman, Y., Louis-Sylvestre, C., P, Macek, A, Mombet, A, Moumen, G, Pourcher, F, Rozet, Salas R, Sanchez, A, Seguin-givelet, E, Tribillon, V, Crenn, Vergie S, De, E, Duchalais, F, Espitalier, C, Ferron, H, Fragnaud, O, Malard, N, Regenet, J, Rigaud, Y, Varenne, D, Waast, U, Bork, M, Distler, J, Fritzmann, J, Kirchberg, C, Praetorius, C, Riediger, J, Weitz, T, Welsch, P, Wimberger, K, Beyer, C, Kamphues, J, Lauscher, FN, Loch, C, Schineis, M, Albertsmeier, M, Angele, A, Kappenberger, H, Niess, T, Schiergens, J, Werner, R, Becker, J, Jonescheit, J, Doerner, R, Seiberth, I, Pergolini, D, Reim, J, Herzberg, H, Honarpisheh, T, Strate, C, Boeker, I, Hakami, J, Mall, P, Liokatis, W, Smolka, N, Vassos, Mannheim, K, Nowak, T, Reinhard, F, Hölzle, A, Modabber, P, Winnand, M, Anthuber, E, Shiban, B, Sommer, F, Sommer, S, Wolf, H, Howaldt, M, Knitschke, P, Kauffmann, S, Wolfer, J, Kleeff, K, Lorenz, C, Michalski, U, Ronellenfitsch, Saale, Schneider R., E, Bertolani, A, Königsrainer, MW, Löffler, M, Quante, C, Steidle, L, Überrück, C, Yurttas, CS, Betz, J, Bewarder, A, Böttcher, S, Burg, C, Busch, M, Dreimann, KH, Frosch, M, Gosau, A, Heuer, J, Izbicki, TO, Klatte, D, Koenig, N, Moeckelmann, C, Nitschke, D, Perez, M, Priemel, A, Reiter, R, Smeets, U, Speth, M, Stangenberg, S, Thole, FG, Uzunoglu, L, Viezens, T, Vollkommer, N, Zeller, MJ, Battista, K, Gillen, A, Hasenburg, S, Krajnak, VC, Linz, R, Schwab, Amo-Antwi, K., A, Appiah-kubi, T, Konney, A, Tawiah, S, Boatey, A, Issaka, Korsah, M.A., M, Sheriff, K, Angelou, D, Haidopoulos, A, Rodolakis, P, Antonakis, K, Bramis, L, Chardalias, I, Contis, N, Dafnios, D, Dellaportas, G, Fragulidis, A, Gklavas, M, Konstadoulakis, N, Memos, I, Papaconstantinou, A, Polydorou, T, Theodosopoulos, A, Vezakis, MI, Antonopoulou, DK, Manatakis, N, Tasis, N, Arkadopoulos, N, Danias, P, Economopoulou, M, Frountzas, P, Kokoropoulos, A, Larentzakis, N, Michalopoulos, C, Nastos, S, Parasyris, E, Pikoulis, J, Selmani, T, Sidiropoulos, P, Vassiliu, K, Bouchagier, S, Klimopoulos, D, Paspaliari, G, Stylianidis, D, Akrivou, K, Baxevanidou, K, Bouliaris, P, Chatzikomnitsa, G, Delinasios, C, Doudakmanis, M, Efthimiou, A, Giaglaras, C, Kalfountzos, C, Kolla, G, Koukoulis, K, Zervas, S, Zourntou, I, Baloyiannis, A, Diamantis, E, Gkrinia, J, Hajiioannou, C, Korais, O, Koukoura, K, Perivoliotis, A, Saratziotis, C, Skoulakis, D, Symeonidis, K, Tepetes, G, Tzovaras, D, Zacharoulis, V, Alexoudi, K, Antoniades, I, Astreidis, P, Christidis, D, Deligiannidis, T, Grivas, O, Ioannidis, I, Kalaitsidou, L, Loutzidou, A, Mantevas, D, Michailidou, E, Nikolaidou, S, Papadopoulou, K, Paraskevopoulos, S, Politis, A, Stavroglou, D, Tatsis, I, Tilaveridis, K, Vahtsevanos, G, Venetis, I, Karaitianos, T, Tsirlis, K, Dinas, Margioula-Siarkou, C., S, Petousis, E, Baili, A, Charalabopoulos, T, Liakakos, D, Schizas, E, Spartalis, A, Syllaios, C, Zografos, C, Anthoulakis, Christou, C.D., V, Papadopoulos, A, Tooulias, D, Tsolakidis, G, Tsoulfas, D, Zouzoulas, E, Athanasakis, E, Chrysos, I, Tsiaoussis, S, Xenaki, E, Xynos, Duarte A, Barrios, Muralles I, Lopez, MJ, Lowey, AL, Portilla, G, Recinos, JYK, Chan, Chan, S.M., CCN, Chong, K, Futaba, Ho, M.F., SF, Hon, RWH, Lau, TWC, Mak, CF, Ng, CSH, Ng, KKC, Ng, SSM, Ng, AYB, Teoh, JY, Teoh, CC, Foo, B, Banky, N, Suszták, S, Misra, P, Pareek, JR, Vishnoi, S, Ambre, V, Balasubiramaniyan, P, Chappity, I, Chaudhary, L, Colney, MK, Das, M, Imaduddin, A, Jain, SK, Jena, M, Kar, S, Mandal, A, Mishra, SS, Mishra, TS, Mishra, JK, Mitra, Y, Mittal, DK, Muduly, P, Nayak, PK, Parida, P, Pradhan, DK, Rajan, E, Rebba, DK, Samal, A, Singh, M, Sultania, SP, Agarwal, A, Agrawal, RK, Arora, J, 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Ladd, C, Long, H, Malapati, A, Margalit, S, Rapaport, J, Rose, K, Stevens, L, Tsai, D, Vervoort, P, Yesantharao, A, Dehal, D, Klaristenfeld, K, Huynh, H, Kaafarani, L, Naar, M, Qadan, L, Brown, I, Ganly, JE, Mullinax, N, Alpert, C, Gillezeau, Miles DDS MD, F.A.C.S.B.A., E, Taioli, DE, Cha, E, Gleeson, C, Horn, U, Sarpel, N, Gusani, J, Hazelton, J, Maines, JS, Oh, A, Ssentongo, P, Ssentongo, A, Bhama, K, Colling, M, Najarian, M, Azam, A, Choudhry, W, Marx, Y, Abedin, G, Arzumanov, R, Chokshi, S, Gabrilovich, N, Glass, E, Kalyoussef, Parvin-Nejad, F.P., D, Roden, J, Stein, Suarez-Ligon, A., G, Tsui, K, Zhao, J, Fleming, A, Fuson, J, Gigliotti, A, Ovaitt, Y, Ying, MK, Abel, V, Andaya, K, Bigay, Boeck, M.A., H, Chern, C, Corvera, El-Sayed, I., A, Glencer, P, Ha, Hamilton, B.C.S., C, Heaton, K, Hirose, Jablons, D.M., KS, Kirkwood, LZ, Kornblith, JR, Kratz, RH, Lee, PN, Miller, EK, Nakakura, Nunez-Garcia, B., RJ, O’Donnell, D, Ozgediz, P, Park, B, Robinson, A, Sarin, B, Sheu, MG, Varma, KC, Wai, R, Wustrack, MJ, Xu, M, Zimel, D, CA) Beswick, J, Goddard, J, Manor, J, Song, Springs/Loveland, Denver/Colorado, A, Cioci, W, Pavlis, K, Rakoczy, G, Ruiz, R, Saberi, T, Fullmer, C, Gaskill, N, Gross, K, Kiong, CL, Roland, SN, Zafar, M, Abdallah, A, Abouassi, E, Aigbivbalu, M, Almasri, J, Eid, B, George, G, Kulkarni, H, Marwan, M, Mehdi, Andrés M, San, J, Sundaresan, SG, Aoun, VS, Ban, HH, Batjer, K, Bosler, J, Caruso, B, Sumer, D, Abbott, A, Acher, T, Aiken, J, Barrett, E, Foley, PB, Schwartz, AT, Hawkins, A, Maiga, NM, Ruzgar, M, Sion, S, Ullrich, J, Laufer, S, Scasso, Al-Naggar, H., Al-Shehari, M., A, Almassaudi, M, Alsayadi, R, Alsayadi, M, Nahshal, S, Shream, S, AL-Ameri, M, Aldawbali, Fotopoulou, Christina, Khan, Tabassum, Bracinik, Juraj, Glasbey, James, Abu-Rustum, Nadeem, Chiva, Luis, Fagotti, Anna, Fujiwara, Keiichi, Ghebre, Rahel, Gutelkin, Murat, Konney, Thomas O., Ng, Joseph, Pareja, Rene, Kottayasamy Seenivasagam, Rajkumar, Sehouli, Jalid, Surappa, Shylasree T.S., and Leung, Elaine
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- 2022
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4. Molecular tumor board
- Author
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M. La Mantia, G. Busuito, V. Spinnato, V. Gristina, A. Galvano, S. Cutaia, N. Barraco, A. Perez, S. Cusenza, L. Incorvaia, G. Badalamenti, A. Russo, and V. Bazan
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- 2023
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- View/download PDF
5. List of contributors
- Author
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M. Arbitrio, G. Badalamenti, N. Barraco, V. Bazan, M. Bono, C. Brando, G. Busuito, F. Buttitta, K. Calcara, D. Cancelliere, E. Capoluongo, D. Caracciolo, M. Castiglia, A. Cordua, O. Cuomo, S. Cusenza, S. Cutaia, M. Del Re, M.T. Di Martino, M. D’Apolito, D. Fanale, L. Felicioni, L. Fiorillo, A. Fiorino, A. Galvano, A. Giordano, A. Giurintano, M. Greco, V. Gristina, F. Iacono, L. Incorvaia, M. La Mantia, E. Lianidou, U. Malapelle, A. Marchetti, A. Navicella, E. Pedone, A. Perez, P. Pisapia, A. Pivetti, C. Rolfo, R. Rossetti, A. Russo, R. Scalia, V. Spinnato, N. Staropoli, P. Tagliaferri, P. Tassone, S. Taverna, G. Troncone, and V. Uppolo
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- 2023
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- View/download PDF
6. Current clinically validated applications of liquid biopsy
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E. Capoluongo, C. Rolfo, A. Galvano, V. Gristina, A. Perez, N. Barraco, M. La Mantia, L. Incorvaia, G. Badalamenti, A. Russo, and V. Bazan
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- 2023
- Full Text
- View/download PDF
7. Liquid biopsy and immunotherapy: is all that glitter gold?
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L. Incorvaia, A. Perez, C. Brando, V. Gristina, M. La Mantia, M. Castiglia, D. Fanale, A. Galvano, G. Badalamenti, A. Russo, and V. Bazan
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- 2023
- Full Text
- View/download PDF
8. Liquid biopsy: a right tool in a right context?
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M. La Mantia, S. Cutaia, V. Gristina, A. Galvano, E. Capoluongo, C. Rolfo, U. Malapelle, L. Incorvaia, G. Badalamenti, A. Russo, and V. Bazan
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- 2023
- Full Text
- View/download PDF
9. Future perspectives
- Author
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L. Incorvaia, M. La Mantia, S. Cutaia, V. Gristina, A. Galvano, N. Barraco, A. Perez, G. Badalamenti, A. Russo, and V. Bazan
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- 2023
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10. 69P Trabectedin rechallenge for the treatment of adults with advanced soft tissue sarcoma (STS): A pilot study (Re-Trabe)
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G. Badalamenti, L. Algeri, A. Dimino, L. Magrin, I. De Luca, R. Sciacchitano, F. Alimondi, V. Gennusa, I. Caiozzo, T.D. Bazan Russo, A. Galvano, V. Gristina, V. Bazan, L. Incorvaia, and A. Russo
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Cancer Research ,Oncology - Published
- 2023
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- View/download PDF
11. 904MO Anthracycline-related cardiotoxicity in breast cancer patients carrying mutational signature of homologous recombination deficiency (HRD)
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L. Incorvaia, A. Fiorino, S. Gori, S. Cinieri, G. Curigliano, A. Toss, L. Cortesi, G.R.R. Ricciardi, R. Chiari, M. Peri, C. Brando, T.D. Bazan Russo, V. Gristina, A. Galvano, G. Damerino, I.U. Carreca, G. Novo, G. Badalamenti, V. Bazan, and A. Russo
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Oncology ,Hematology - Published
- 2022
- Full Text
- View/download PDF
12. Outcomes of three lines Atezolizumab plus Bevacizumab-based sequential treatment for hepatocellular carcinoma: a simulation model
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C. Celsa, G. Cabibbo, S. Battaglia, P. Giuffrida, G.E.M. Rizzo, M. Grova, C.M. Giacchetto, G. Rancatore, C. Stornello, M.V. Grassini, G. Badalamenti, M. Enea, A. Craxì, V. Di Marco, and C. Cammà
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Hepatology ,Gastroenterology - Published
- 2022
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13. EP16.01-013 The Diagnostic Accuracy of Tumor Mutational Burden in Advanced NSCLC: An Individual Patient Data Meta-Analysis
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M. La Mantia, V. Gristina, A. Galvano, N. Barraco, A. Perez, S. Cutaia, d. Sardo, S. Inguglia, G. Busuito, V. Spinnato, F. Iacono, L. Insalaco, L. Castellana, V. Calò, s. cusenza, F. Fulfaro, L. Incorvaia, G. Badalamenti, T.D. Bazan Russo, S. Vieni, A. Russo, and V. Bazan
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Pulmonary and Respiratory Medicine ,Oncology - Published
- 2022
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- View/download PDF
14. 1094P The clinical potential of circulating-free DNA (cfDNA) for real-time longitudinally monitoring clinical outcomes in a real-world first-line non-small cell lung cancer (NSCLC) prospective study
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V. Gristina, N. Barraco, A. Galvano, M. La Mantia, S. Cutaia, F. Iacono, C. Lisanti, S. Inguglia, D. Sardo, A. Perez, S. Cusenza, L. Castellana, T.D. Bazan Russo, S. Vieni, F. Fulfaro, L. Incorvaia, G. Badalamenti, V. Bazan, and A. Russo
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Oncology ,Hematology - Published
- 2022
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- View/download PDF
15. P-264 The molecular-metabolic interplay in metastatic gastrointestinal stromal tumors (GISTs): The predictive role of body mass index
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L. Incorvaia, C. Brando, L. Algeri, A. Dimino, E. Pedone, R. Schiacchitano, L. Magrin, A. Fiorino, A. Perez, N. Barraco, M. Bono, D. Cancelliere, A. Pivetti, T. Bazan Russo, S. Contino, V. Gristina, A. Galvano, V. Bazan, A. Russo, and G. Badalamenti
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Oncology ,Hematology - Published
- 2022
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- View/download PDF
16. P-173 Understanding the treatment algorithm of patients with advanced G2 gastroenteropancreatic neuroendocrine neoplasms: A single-institution retrospective analysis
- Author
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M. Peri, L. Incorvaia, V. Spinnato, L. Corsini, R. Scalia, A. Dimino, L. Algeri, R. Schiacchitano, L. Magrin, A. Galvano, V. Gristina, S. Cusenza, V. Bazan, G. Badalamenti, and A. Russo
- Subjects
Oncology ,Hematology - Published
- 2022
- Full Text
- View/download PDF
17. Elective cancer surgery in COVID-19–Free surgical pathways during the SARS-cov-2 pandemic: An international, multicenter, comparative cohort study
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James C Glasbey, Dmitri Nepogodiev, Joana Ff Simoes, Omar Omar, Elizabeth Li, Mary L Venn, Mohammad Abou Chaar, Vita Capizzi, Daoud Chaudhry, Anant Desai, Jonathan G Edwards, Jonathan P Evans, Marco Fiore, Jose Flavio Videria, Samuel J Ford, Ian Ganyli, Ewen A Griffiths, Rohan R Gujjuri, Angelos G Kolias, Haytham Ma Kaafarani, Ana Minaya-Bravo, Siobhan C McKay, Helen M Mohan, Keith Roberts, Carlos San Miguel-Méndez, Peter Pockney, Richard Shaw, Neil J Smart, Grant D Stewart, Sudha Sundar, Raghavan Vidya, Aneel A Bhangu, James C Glasbey, Omar Omar, Aneel A Bhangu, Kwabena Siaw-Acheampong, Ruth A Benson, Edward Bywater, Daoud Chaudhry, Brett E Dawson, Jonathan P Evans, James C Glasbey, Rohan R Gujjuri, Emily Heritage, Conor S Jones, Sivesh K Kamarajah, Chetan Khatri, Rachel A Khaw, James M Keatley, Andrew Knight, Samuel Lawday, Elizabeth Li, Harvinder S Mann, Ella J Marson, Kenneth A McLean, Siobhan C McKay, Emily C Mills, Dmitri Nepogodiev, Gianluca Pellino, Maria Picciochi, Elliott H Taylor, Abhinav Tiwari, Joana Ff Simoes, Isobel M Trout, Mary L Venn, Richard Jw Wilkin, Aneel A Bhangu, James C Glasbey, Neil J Smart, Ana Minaya-Bravo, Jonathan P Evans, Gaetano Gallo, Susan Moug, Francesco Pata, Peter Pockney, Salomone Di Saverio, Abigail Vallance, Dale Vimalchandran, Ewen A Griffiths, Sivesh K Kamarajah, Richard Pt Evans, Philip Townend, Keith Roberts, Siobhan McKay, John Isaac, Sohei Satoi, John Edwards, Aman S Coonar, Adrian Marchbank, Edward J Caruana, Georgia R Layton, Akshay Patel, Alessandro Brunelli, Samuel Ford, Anant Desai, Alessandro Gronchi, Marco Fiore, Max Almond, Fabio Tirotta, Sinziana Dumitra, Angelos Kolias, Stephen J Price, Daniel M Fountain, Michael D Jenkinson, Peter Hutchinson, Hani J Marcus, Rory J Piper, Laura Lippa, Franco Servadei, Ignatius Esene, Christian Freyschlag, Iuri Neville, Gail Rosseau, Karl Schaller, Andreas K Demetriades, Faith Robertson, Alex Alamri, Richard Shaw, Andrew G Schache, Stuart C Winter, Michael Ho, Paul Nankivell, Juan Rey Biel, Martin Batstone, Ian Ganly, Raghavan Vidya, Alex Wilkins, Jagdeep K Singh, Dinesh Thekinkattil, Sudha Sundar, Christina Fotopoulou, Elaine Leung, Tabassum Khan, Luis Chiva, Jalid Sehouli, Anna Fagotti, Paul Cohen, Murat Gutelkin, Rahel Ghebre, Thomas Konney, Rene Pareja, Rob Bristow, Sean Dowdy, T S Shylasree, R Kottayasamy Seenivasagam, Joe Ng, Keiiji Fujiwara, Grant D Stewart, Benjamin Lamb, Krishna Narahari, Alan McNeill, Alexandra Colquhoun, John McGrath, Steve Bromage, Ravi Barod, Veeru Kasivisvanathan, Tobias Klatte, Joana Ff Simoes, Tom Ef Abbott, Sadi Abukhalaf, Michel Adamina, Adesoji O Ademuyiwa, Arnav Agarwal, Murat Akkulak, Ehab Alameer, Derek Alderson, Felix Alakaloko, Markus Albertsmeiers, Osaid Alser, Muhammad Alshaar, Sattar Alshryda, Alexis P Arnaud, Knut Magne Augestad, Faris Ayasra, José Azevedo, Brittany K Bankhead-Kendall, Emma Barlow, David Beard, Ruth A Benson, Ruth Blanco-Colino, Amanpreet Brar, Ana Minaya-Bravo, Kerry A Breen, Chris Bretherton, Igor Lima Buarque, Joshua Burke, Edward J Caruana, Mohammad Chaar, Sohini Chakrabortee, Peter Christensen, Daniel Cox, Moises Cukier, Miguel F Cunha, Giana H Davidson, Anant Desai, Salomone Di Saverio, Thomas M Drake, John G Edwards, Muhammed Elhadi, Sameh Emile, Shebani Farik, Marco Fiore, J Edward Fitzgerald, Samuel Ford, Tatiana Garmanova, Gaetano Gallo, Dhruv Ghosh, Gustavo Mendonça Ataíde Gomes, Gustavo Grecinos, Ewen A Griffiths, Madalegna GrÜndl, Constantine Halkias, Ewen M Harrison, Intisar Hisham, Peter J Hutchinson, Shelley Hwang, Arda Isik, Michael D Jenkinson, Pascal Jonker, Haytham Ma Kaafarani, Debby Keller, Angelos Kolias, Schelto Kruijff, Ismail Lawani, Hans Lederhuber, Sezai Leventoglu, Andrey Litvin, Andrew Loehrer, Markus W Löffler, Maria Aguilera Lorena, Maria Marta Modolo, Piotr Major, Janet Martin, Hassan N Mashbari, Dennis Mazingi, Symeon Metallidis, Ana Minaya-Bravo, Helen M Mohan, Rachel Moore, David Moszkowicz, Susan Moug, Joshua S Ng-Kamstra, Mayaba Maimbo, Ionut Negoi, Milagros Niquen, Faustin Ntirenganya, Maricarmen Olivos, Kacimi Oussama, Oumaima Outani, Marie Dione Parreno-Sacdalanm, Francesco Pata, Carlos Jose Perez Rivera, Thomas D Pinkney, Willemijn van der Plas, Peter Pockney, Ahmad Qureshi, Dejan Radenkovic, Antonio Ramos-De la Medina, Keith Roberts, April C Roslani, Martin Rutegård, Juan José Segura-Sampedro, Irène Santos, Sohei Satoi, Raza Sayyed, Andrew Schache, Andreas A Schnitzbauer, Justina O Seyi-Olajide, Neil Sharma, Richard Shaw, Sebastian Shu, Kjetil Soreide, Antonino Spinelli, Grant D Stewart, Malin Sund, Sudha Sundar, Stephen Tabiri, Philip Townend, Georgios Tsoulfas, Gabrielle H van Ramshorst, Raghavan Vidya, Dale Vimalachandran, Oliver J Warren, Duane Wedderburn, Naomi Wright, C Allemand, L Boccalatte, M Figari, M Lamm, J Larrañaga, C Marchitelli, F Noll, D Odetto, M Perrotta, J Saadi, L Zamora, C Alurralde, E L Caram, D Eskinazi, J P Mendoza, M Usandivaras, R Badra, A Esteban, J S García, P M García, J I Gerchunoff, S M Lucchini, M A NIgra, L Vargas, T Hovhannisyan, A Stepanyan, T Gould, R Gourlay, B Griffiths, S Gananadha, M McLaren, J Cecire, N Joshi, S Salindera, A Sutherland, J H Ahn, G Charlton, S Chen, N Gauri, R Hayhurst, S Jang, F Jia, C Mulligan, W Yang, G Ye, H Zhang, M Ballal, D Gibson, D Hayne, J Moss, T Richards, P Viswambaram, U G Vo, J Bennetts, T Bright, M Brooke-Smith, R Fong, B Gricks, Y H Lam, B S Ong, M Szpytma, D Watson, K Bagraith, S Caird, E Chan, C Dawson, D Ho, E Jeyarajan, S Jordan, A Lim, G J Nolan, A Oar, D Parker, H Puhalla, A Quennell, L Rutherford, P Townend, M Von Papen, M Wullschleger, A Blatt, D Cope, N Egoroff, M Fenton, J Gani, N Lott, P Pockney, N Shugg, M Elliott, D Phung, D Phan, D Townend, C Bong, J Gundara, A Frankel, S Bowman, G R Guerra, J Bolt, K Buddingh, N N Dudi-Venkata, S Jog, H M Kroon, T Sammour, R Smith, C Stranz, M Batstone, K Lah, W McGahan, D Mitchell, A Morton, A Pearce, M Roberts, G Sheahan, B Swinson, N Alam, S Banting, L Chong, 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J R Tan, A Thomas, P Whelan, A Anzak, A Banerjee, O Fuwa, F Hughes, J D Jayasinghe, C Knowles, H Kocher, I Leal Silva, F S Ledesma, A Minicozzi, L Navaratne, R Rahman, R Ramamoorthy, C Sohrabi, M Thaha, B Thakur, M Venn, V Yip, R Baumber, J Parry, S Evans, L Jeys, G Morris, M Parry, J Stevenson, N Ahmadi, G Aresu, Z M Barrett-Brown, A S Coonar, H Durio Yates, D Gearon, J Hogan, M King, A Peryt, I S Pradeep, C Smith, M Adishesh, R Atherton, K Baxter, M Brocklehurst, M Chaudhury, N Krishnamohan, J McAleer, G Owens, E Parkin, P Patkar, I Phang, A Aladeojebi, M Ali, B Barmayehvar, A Gaunt, M Gowda, E Halliday, M Kitchen, F Mansour, M Thomas, D Zakai, N Abbassi-Ghadi, H Assalaarachchi, A Currie, M Flavin, A Frampton, M Hague, C Hammer, J Hopper, J Horsnell, S Humphries, A Kamocka, T K Madhuri, S Preston, P Singh, J Stebbing, A Tailor, D Walker, F Aljanadi, M Jones, P Mhandu, C O'Donnell, R Turkington, Z Al-Ishaq, S Bhasin, A S Bodla, A Burahee, A Crichton, R Fossett, N Pigadas, S Pickford, E Rahman, D Snee, R Vidya, N Yassin, F Colombo, D Fountain, M T Hasan, K Karabatsou, R Laurente, O Pathmanaban, A Al-Mukhtar, S Brown, J Edwards, A Giblin, C Kelty, M Lee, G Lye, T Newman, A Sharkey, C Steele, N Sureshkumar Shah, E Whitehall, R Athwal, A Baker, L Jones, C Konstantinou, S Ramcharan, S Singh, J Vatish, R Wilkin, M Ethunandan, G K Sekhon, H Shields, R Singh, F Wensley, S Lawday, A Lyons, T Abbott, S Anwar, K Ghufoor, C Sohrabi, E Chung, R Hagger, A Hainsworth, A Karim, H Owen, A Ramwell, K Williams, C Baker, A Davies, J Gossage, M Kelly, W Knight, J Hall, G Harris, G James, C Kang, D J Lin, A D Rajgor, T Royle, R Scurrah, B Steel, L J Watson, D Choi, R Hutchison, A Jain, V Luoma, H Marcus, R May, A Menon, B Pramodana, L Webber, I A Aneke, P Asaad, B Brown, J Collis, S Duff, A Khan, F Moura, B Wadham, H Warburton, T Elmoslemany, M Jenkinson, C Millward, R Zakaria, S Mccluney, C Parmar, S Shah, J Allison, M S Babar, B Collard, S Goodrum, K Lau, A Patel, R Scott, E Thomas, H Whitmore, D Balasubramaniam, B Jayasankar, S Kapoor, A Ramachandran, A Elhamshary, Smb Imam, K Kapriniotis, V Kasivisvanathan, J Lindsay, S Rakhshani-Moghadam, N Beech, M Chand, L Green, N Kalavrezos, H Kiconco, R McEwen, C Schilling, D Sinha, J Pereca, J Singh, S Chopra, D Egbeare, R Thomas, T Combellack, Sef Jones, M Kornaszewska, M Mohammed, A Sharma, G Tahhan, V Valtzoglou, J Williams, P Eskander, K Gash, L Gourbault, M Hanna, T Maccabe, C Newton, J Olivier, S Rozwadowski, E Teh, D West, H Al-Omishy, M Baig, H Bates, G Di Taranto, K Dickson, N Dunne, C Gill, D Howe, D Jeevan, A Khajuria, K Martin-Ucar AMcEvoy, P Naredla, V Ng, S Robertson, M Sait, D R Sarma, S Shanbhag, T Shortland, S Simmonds, J Skillman, N Tewari, G Walton, M A Akhtar, A Brunt, J McIntyre, K Milne, M M Rashid, A Sgro, K E Stewart, A Turnbull, M Aguilar Gonzalez, S Talukder, C Boyle, D Fernando, K Gallagher, A Laird, D Tham, M Bath, P Patki, C Sohrabi, C Tanabalan, T Arif, C Magee, T Nambirajan, S Powell, R Vinayagam, I Flindall, A Hanson, V Mahendran, S Green, M Lim, L MacDonald, V Miu, L Onos, K Sheridan, R Young, F Alam, O Griffiths, C Houlden, R Jones, V S Kolli, A K Lala, S Leeson, R Peevor, Z Seymour, L Chen, E Henderson, A Loehrer, K Brown, D Fleming, A Haynes, C Heron, C Hill, H Kay, E Leede, K McElhinney, K Olson, E C Osterberg, C Riley, P Srikanth, M Thornhill, D Blazer, G DiLalla, E S Hwang, W Lee, M Lidsky, J Plichta, L Rosenberger, R Scheri, K Shah, K Turnage, J Visgauss, S Zani, J Farma, J Clark, D Kwon, E Etchill, H E Gabre-Kidan AJenny, A Kent, M Ladd, C Long, H Malapati, A Margalit, S Rapaport, J Rose, K Stevens, L Tsai, D Vervoort, P Yesantharao, A Dehal, D Klaristenfeld, K Huynh, L Brown, I Ganly, J Mullinax, N Gusani, J Hazelton, J Maines, J S Oh, A Ssentongo, P Ssentongo, M Azam, A Choudhry, W Marx, J Fleming, A Fuson, J Gigliotti, A Ovaitt, Y Ying, M K Abel, V Andaya, K Bigay, M A Boeck, L Chen, H Chern, C Corvera, I El-Sayed, A Glencer, P Ha, Bcs Hamilton, C Heaton, K Hirose, D M Jablons, K Kirkwood, L Z Kornblith, J R Kratz, R Lee, P N Miller, E Nakakura, B Nunez-Garcia, R O'Donnell, D Ozgediz, P Park, B Robinson, A Sarin, B Sheu, M Varma, K Wai, R Wustrack, M J Xu, D Beswick, J Goddard, J Manor, J Song, T Fullmer, C Gaskill, N Gross, K Kiong, C L Roland, S N Zafar, M Abdallah, A Abouassi, M Almasri, G Kulkarni, H Marwan, M Mehdi, S Aoun, V S Ban, H H Batjer, J Caruso, D Abbott, A Acher, T Aiken, J Barrett, E Foley, P Schwartz, S N Zafar, A Hawkins, A Maiga, J Laufer, S Scasso
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Aged, 80 and over ,Male ,Critical Care ,SARS-CoV-2 ,International Cooperation ,COVID-19 ,Middle Aged ,Cohort Studies ,Logistic Models ,Postoperative Complications ,Elective Surgical Procedures ,Neoplasms ,Outcome Assessment, Health Care ,Humans ,Female ,Epidemics ,Aged - Abstract
PURPOSE As cancer surgery restarts after the first COVID-19 wave, health care providers urgently require data to determine where elective surgery is best performed. This study aimed to determine whether COVID-19–free surgical pathways were associated with lower postoperative pulmonary complication rates compared with hospitals with no defined pathway. PATIENTS AND METHODS This international, multicenter cohort study included patients who underwent elective surgery for 10 solid cancer types without preoperative suspicion of SARS-CoV-2. Participating hospitals included patients from local emergence of SARS-CoV-2 until April 19, 2020. At the time of surgery, hospitals were defined as having a COVID-19–free surgical pathway (complete segregation of the operating theater, critical care, and inpatient ward areas) or no defined pathway (incomplete or no segregation, areas shared with patients with COVID-19). The primary outcome was 30-day postoperative pulmonary complications (pneumonia, acute respiratory distress syndrome, unexpected ventilation). RESULTS Of 9,171 patients from 447 hospitals in 55 countries, 2,481 were operated on in COVID-19–free surgical pathways. Patients who underwent surgery within COVID-19–free surgical pathways were younger with fewer comorbidities than those in hospitals with no defined pathway but with similar proportions of major surgery. After adjustment, pulmonary complication rates were lower with COVID-19–free surgical pathways (2.2% v 4.9%; adjusted odds ratio [aOR], 0.62; 95% CI, 0.44 to 0.86). This was consistent in sensitivity analyses for low-risk patients (American Society of Anesthesiologists grade 1/2), propensity score–matched models, and patients with negative SARS-CoV-2 preoperative tests. The postoperative SARS-CoV-2 infection rate was also lower in COVID-19–free surgical pathways (2.1% v 3.6%; aOR, 0.53; 95% CI, 0.36 to 0.76). CONCLUSION Within available resources, dedicated COVID-19–free surgical pathways should be established to provide safe elective cancer surgery during current and before future SARS-CoV-2 outbreaks.
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- 2021
18. 32P Can circulating immune checkpoints and KIT exon 11 mutations be prognostic factors in metastatic gastrointestinal stromal tumors?
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C. Brando, D. Fanale, L. Incorvaia, L. Algeri, N. Barraco, L.R. Corsini, A. Cucinella, A. Dimino, C. Filorizzo, A. Fiorino, G. Madonia, L. Magrin, E. Pedone, M.R. Ricciardi, R. Sciacchitano, R. Scalia, G. Badalamenti, V. Bazan, and A. Russo
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Oncology ,Hematology - Published
- 2021
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19. ENSAIOS ACADÊMICOS DOUTRINÁRIOS. PROCESSO DE CONHECIMENTO – RESPOSTAS DO RÉU E SANEAMENTO Coleção Ensaios acadêmicos doutrinários - Volume 2
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B. F. Saboya, I. C. T. França, C. G. F. Marinho, E. T. Silva, V. S. Pinheiro, R. S. Chaves, L. L. Gondim Junior, I. F. Gouveia, A. C. D. Pinheiro, A. F. G. Badalamenti, L. G. L. Araújo, A. L. Aragão, C. M. C. Botelho, C. M. R. Monteiro, A. L. L. B. Oliveira, J. F. C. Pinto, R. C. S. Coelho, I. F. Moreira, Isabel da Silva Borges, Rômulo Weber Teixeira de Andrade, C. R. Gangôrra, R. S. C. Bret, C. M. Falcão, B. P. C. Melo, G. A. C. Linhares, F. M. M. Queiroz, I. F. Lucas, and R. A. Amorim
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- 2019
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20. P1270Effects of blood pressure variability on layer-specific longitudinal strain in hypertensionP1271 Left atrial dynamics and diastolic function in hypertensive patientsP1272Echocardiographic evaluation of right ventricular function in patients with chronic obstructive pulmonary disease in comparison with healthy groupP1273The impact of preeclampsia on myocardial recovery in women with peripartum cardiomyopahty - speckle tracking studyP1274Diagnostic accuracy of bedside lung ultrasonography in emergency (BLUE) protocol in discriminating cardiovascular causes of acute dyspneaP1275Heart failure with preserved and reduced ejection fraction - the mysterious role of ghrelin in the improvement of cardiac mechanicsP1276Prolonged atrial electromechanical coupling interval in patients with vitamin d deficiencyP1277Early detection of cardiotoxicity induced by new target therapy by strain echocardiography and arterial stiffnessP1278Long term course of bicuspid aortic valve in patients with and without associated cardiac malformations. A single-centre, retrospective cohort studyP1279Left ventricular mechanics in ALCAPA patients post successful repair: really normal?P1280Next generation stress echo computerized software (SECS)P1281Non invasive hemodynamic profile of patients developing inducible ischemia at dobutamine stress echocardiography: a global longitudinal strain investigation P1282Silent myocardial ischaemia is highly prevalent in patients with chronic obstructive pulmonary disease referred for dobutamine stress echocardiographyP1283Silent chronic obstructive pulmonary disease is highly prevalent in patients referred for dobutamine stress echocardiography with shortness of breathP1284Exercise echocardiography for the prediction of mortality after coronary artery by-pass surgery.P1285Exercise echocardiography reveals higher LV myocardial performance efficiency in adolescent elite athletes compared to non-athlete controlsP1287Impact of subclinical left ventricular myocardial dysfunction on exercise capacity in young patients with type 1 diabetes mellitusP1288Mitral annular plane systolic excursion as additional evaluation for left ventricular ejection fractionP12892 dimensional global longitudinal strain and mitral annular plane systolic?excursion as additional evaluation for left ventricular ejection fractionP1290Assessment of the left atrial appendage systolic function by 3 dimensional transoesophageal echocardiographyP1291Functional anatomy of mitral valve in obstructive hypertrophic cardiomyopathy patientsP1292Right ventricle deformation indices discriminate better than left ventricle deformation indices and fractional shortening between healthy and hypothermia treated asphyxiated neonatesP1293Determinants of myocardial strain in chronic myocardial infarction
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H. Ballo, E. Nestaas, EN. Pavlyukova, A. Garcia Martin, EJ. Cho, C. Ruisanchez Villar, GE. Pieles, JC. Peteiro Vazquez, J. O'driscoll, C. Santoro, Q. Ciampi, G. Di Salvo, J. Lamy, G. Novo, Y. Hacioglu, K. Kupczynska, A. Ledakowicz-Polak, K. Hristova, N. Behzadnia, E. Chamodraka, W-C Tsai, W-H Lee, Y-W Liu, E. Kallistratos, D. Athanasiou, S. Giannitsi, C. Manetos, G. Athanasiadis, M. Asonitis, N. Kouremenos, A. Tsoukas, A. Manolis, M. Asadpour-Piranfar, BABAK Sharif-Kashani, N. Ameli, R. Marinov, G. Stamenov, K. Chacheva, M. Michova, S. Persenska, N. Dimova, A. Racheva, G. Krauza, K. Stokfisz, M. Zielinska, BW. Michalski, P. Trzcinski, D. Miskowiec, L. Peczek, P. Lipiec, JD. Kasprzak, T. Karabag, ME. Piskinpasa, F. Sametoglu, Y. Yuksel, D. Di Lisi, M. Meschisi, F. Cosentino, V. Bonomo, G. Mazzola, F. D'angelo, I. Vella, E. Bronte, G. Badalamenti, A. Russo, R. Chopard, F. Ecarnot, C. Tchaoussoff, F. Schiele, YF. Bernard, N. Al Qweai, Z. Issa, N. Muhanna, M. Habdan, V. Pergola, B. Fadel, G. Siblini, M. Paterni, L. Cortigiani, R. Citro, R. Sicari, M. Galderisi, E. Bossone, P. Colonna, E. Picano, F. Ilardi, V. Schiano-Lomoriello, R. Esposito, S. Cocozza, F. Lo Iudice, M. Lembo, B. Trimarco, B. Madden, D. Giannoglou, V. Peresso, A. Marciniak, S. Nazir, R. Sharma, A. Bouzas-Mosquera, P. Pardo, F. Broullon-Molanes, JM. Vazquez-Rodriguez, J. Luszczak, L. Gowing, AG. Stuart, CA. Williams, FJ. Gonzalez Vilchez, M. Piedra Leon, M. Marigomez Estrada, C. Pesquera Gonzalez, J. Ruano Calvo, J. Zarauza Navarro, R. Martin Duran, JA. Amado Senaris, MY. Jeong, HJ. Kim, MH. Kwak, JL. Moya Mur, C. Fernandez-Golfin, E. Casas Rojo, D. Del Val Martin, A. Pardo Sanz, A. Gonzalez Gomez, R. Hinojar, B. Berlot, JL. Zamorano, AV. Evtushenko, KA. Smushlyaev, RS. Karpov, A. Stoylen, D. Fugelseth, M. Tarkia, M. Haavisto, C. Stark, T. Vahasilta, M. Strandberg, P. Saukko, T. Savunen, J. Knuuti, and A. Saraste
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medicine.medical_specialty ,Ambulatory blood pressure ,Longitudinal strain ,business.industry ,Uncomplicated hypertension ,Speckle tracking echocardiography ,General Medicine ,030204 cardiovascular system & hematology ,03 medical and health sciences ,0302 clinical medicine ,Blood pressure ,medicine.anatomical_structure ,Ventricle ,Internal medicine ,medicine ,Cardiology ,Radiology, Nuclear Medicine and imaging ,Cardiology and Cardiovascular Medicine ,High group ,Longitudinal deformation ,business - Abstract
Background Our previous study showed sub-epicardial longitudinal strain (EpiLS) was an independent prognostic factor for worse outcome in regular treated hypertension but not global longitudinal strain (GLS) and sub-endocardial longitudinal strain (EndLS). Increased blood pressure variability (BPV) has been found associated with target organ damage in hypertension. However, effects of BPV on layer-specific longitudinal strain have not been well studied. Purpose The aim of this study was to investigate the effects of different blood pressure parameters on layer-specific longitudinal strain in hypertension. Methods This study included 95 patients (57 men, age 65 ± 12 years) with uncomplicated hypertension who have been regularly treated for more than 1 year. Speckle tracking echocardiography was used for measurement of longitudinal deformation from 3 apical views of left ventricle. GLS was measured by automated function imaging (AFI). We further divided into sub-endocardial and sub-epicardial myocardium and measured their longitudinal strain by manual click-and-draw method and averaged from 3 apical views. Blood pressure parameters included office systolic blood pressure (SBP), office diastolic blood pressure (DBP), central SBP and DBP by tonometry, average 24-hour SBP and DBP, and BPV parameters by ambulatory blood pressure monitor. BPV parameters included standard deviation of daytime SBP (DSSD), standard deviation of nighttime SBP (NSSD), standard deviation of daytime DBP (DDSD), and standard deviation of nighttime DBP (NDSD). Results We divided subjects into low and high group according to median level of each strain. No blood pressure parameters were different between low and high EndLS group except week difference in NDSD (9.0 ± 3.4 vs. 7.8 ± 2.0 mmHg, p = 0.051). NSSD (11.2 ± 4.6 vs. 9.3 ± 2.9 mmHg, p = 0.027) and NDSD (9.1 ± 3.4 vs. 7.7 ± 2.0 mmHg, p = 0.031) were significant increased in low GLS group but not other parameters. DDSD (10.3 ± 3.0 vs. 9.0 ± 2.5 mmHg, p = 0.034), NSSD (11.4 ± 4.4 vs. 9.1 ± 3.1 mmHg, p = 0.006), and NDSD (9.2 ± 3.2 vs. 7.6 ± 2.2 mmHg, p = 0.012) were significantly increased in low EpiLS group. Conclusions Only BPV parameters were associated with decreased longitudinal strain in hypertension. Effects of BPV were majorly noted in EpiLS.
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- 2016
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21. Single-Center Experience and Preliminary Results of Intravascular Ultrasound in Endovascular Aneurysm Repair
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F. Pecoraro, U.M. Bracale, A. Farina, G. Badalamenti, F. Ferlito, and M. Lachat
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Surgery ,Cardiology and Cardiovascular Medicine - Published
- 2019
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22. Poster session 5The imaging examinationP1097Correlation between visual and quantitative assessment of left ventricle: intra- and inter-observer agreementP1099Incremental prognostic value of late gadolinium-enhanced by cardiac magnetic resonance in patients with heart failureAnatomy and physiology of the heart and great vesselsP1100Left ventricular geometry and diastolic performance in erectile dysfunction patients; a topic of differential arterial stiffness influenceAssessment of diameters, volumes and massP1101Impact of the percutaneous closure of atrial septal defect on the right heart 'remodeling'P1102Left Ventricular Mass Indexation in Infants, Children and Adolescents: a Simplified Approach for the Identification of Left Ventricular Hypertrophy in Clinical PracticeP1103Impact of trabecules while quantifying cardiac magnetic resonance exams in patients with systemic right ventricleP1104Detection of subclinical atherosclerosis by carotid intima-media thickness: correlation with leukocytes telomere shorteningAssessments of haemodynamicsP1105Flow redirection towards the left ventricular outflow tract: vortex formation is not affected by variations in atrio-ventricular delayAssessment of systolic functionP1106Reproducibility and feasibility of cardiac MRI feature tracking in Fabry diseaseP1107Normal left ventricular strain values by two-dimensional strain echocardiography; result of normal (normal echocardiographic dimensions and functions in korean people) studyP1108Test-retest repeatability of global strain following st-elevation myocardial infarction - a comparison of tagging and feature trackingP1109Cardiotoxicity induced by tyrosine kinase inhibitors in patients with gastrointestinal stromal tumors (GIST)P1110Finite strain ellipses for the analysis of left ventricular principal strain directions using 3d speckle tracking echocardiographyP1111Antihypertensive therapy reduces time to peak longitudinal strainP1112Right ventricular systolic function as a marker of prognosis after inferior myocardial infarction - 5-year follow-upP1113Is artery pulmonary dilatation related with right but also early left ventricle dysfunction in pulmonary artery hypertension?P1114Right ventricular mechanics changes according to pressure overload increasing, a 2D-speckle tracking echocardiographic evaluationAssessment of diastolic functionP1115Paired comparison of left atrial strain from P-wave to P-wave and R-wave to R-waveP1116Diagnostic role of Tissue Doppler Imaging echocardiographic criteria in obese heart failure with preserved ejection fraction patientsP1117Evaluation of diastolic function of right ventricle in idiopathic pulmonary arterial hypertensionP1118Severity and predictors of diastolic dysfunction in a non-hypertensive non-ischemic cohort of Egyptian patients with documented systemic autoimmune disease; pilot reportP1119correlation between ST segment shift and cardiac diastolic function in patients with acute myocardial infarctionIschemic heart diseaseP1120Computed tomography coronary angiography verSus sTRess cArdiac magneTic rEsonance for the manaGement of sYmptomatic revascularized patients: a cost effectiveness study (STRATEGY study)P1121Utility of transmural myocardial mechanic for early infarct size prediction after primary percutaneous coronary intervention in STEMI patientsP1122Progressive Improvements of the echocardiographic deformation parameters in ST Elevation Myocardial Infarction after five years follow-upP1123Long-term prognostic value of left ventricular dyssynchrony as assessed by cardiac magnetic resonance feature-tracking imaging after a first st-segment elevation myocardial infarctionP1124Differences in mitral annulus remodeling in acute anterior ST elevation and acute inferior ST elevation myocardial infarctionP1125Reduction of microvascular injury using a novel theragnostic ultrasound strategy: a first in men feasibility and safety studyP1126Impact of focused echocardiography in clinical decision of patient presented with st elevation myocardial infarction underwent primary angioplastyHeart valve DiseasesP1127Aortic valve area calculation in aortic stenosis: a comparison among conventional and 3D-transesophageal echocardiography and computed tomographyP1128Myocardial fibrosis and microRNA-21 expression in patients with severe aortic valve stenosis and preserved ejection fraction: a 2D speckle tracking echocardiography, tissutal and plasmatic studyP1129Quantification of calcium amount in a new experimental model: a comparison between calibrated integrated backscatter of ultrasound and computed tomographyP1130Altered diffusion capacity in aortic stenosis: role of the right heartP1131Osteoprotegerin predicts all-cause mortality in calcific aortic stenosis patients with preserved left ventricle ejection fraction in long term observationP1132Mitral regurgitation as a risk factor for pulmonary hypertension in patients with aortic stenosisP1133The relationship between the level of plasma B-type natriuretic peptide and mitral stenosisP1134Aortic regurgitation, left ventricle mechanics and vascular load: a single centre 2d derived-speckle tracking studyP1135Feasibility and reproducibility issues limit the usefulness of quantitative colour Doppler parameters in the assessment of chronic aortic and mitral regurgitation severityP1136Predictors of postoperative outcome in degenerative mitral regurgitationP1137Left ventricular mechanical dyssynchrony in patients with severe mitral regurgitation of rheumatic etiology; three dimensional echocardiography studyP1138Functional mitral regurgitation and left atrial dysfunction concur in determining pulmonary hypertension and functional status in subjects with left ventricular systolic dysfunctionP11393D echocardiography allows more effective quantitative assessment of the severity of functional tricuspid regurgitation than conventional 2D/Doppler echocardiographyP1140Prosthetic valve thrombosis: still a severe disease? 10-years experience in a university hospitalP1141Validity of echocardiography in the hospital course of patients with feverP1142Do baseline 3DTEE characteristics of mitral valve apparatus predict long term result in patients undergoing percutaneous valve repair for degenerative regurgitation?P1143Influence of baseline aortic regurgitation on mitral regurgitation change after transcatheter aortic valve replacement for aortic stenosisP1144Prevalence of echocardiography detected significant valvular regurge in subclinical rheumatic carditis in assiut childrenCardiomyopathiesP1145Can we early detect left ventricular systolic dysfunction in patients with Duchenne muscular dystrophy using global longitudinal strain assessment?P1146Prevalence of isolated papillary muscle hypertrophy in young competitive athletesP1147Troponin release after exercise in patients with hypertrophic cardiomyopathy: associations with clinical and mr imaging characteristicsP1148Atrial fibrillation in hypertrophic cardiomyopathy: can we score the risk?P1149Impact of hypertrophy on multiple layer longitudinal deformation in hypertrophy cardiomyopathy and cardiac amyloidosis compared to controlsP1150Functional evaluation in hypertrophic cardiomyopathy combining cardiopulmonary exercise testing combined with exercise-echocardiographyP1151Refinement of the old diagnostic criteria of left ventricular noncompaction cardiomyopathy (LVNC) based on cardiac magnetic resonance (CMR)P1152Differences of clinical characteristics and outcomes between acute myocarditis with preserved and reduced left ventricular systolic functionP1153Value of longitudinal strain for distinguishing left ventricular non-compaction from idiopathic dilated cardiomyopathyP1154Speed of recovery of left ventricular function is not related to the prognosis of Takotsubo cardiomyopathy. A Portuguese multicentre studyP1155Predictors of in-hospital left ventricular systolic function recovery after admission with takotsubo cardiomyopathy. Portuguese multicentre studyP1156Mid-ventricular takotsubo detected by initial echocardiogram associates with recurrence of takotsubo cardiomyopathy - a portuguese multicentre studySystemic diseases and other conditionsP1157Relations between left ventricle remodelling and expression of angiotensin 2 AT2R1 geneP1158Impact of renal denervation on long-term blood pressure variability and surrogate markers of target organ damage in individuals with drug-resistant arterial hypertensionP1159Greater improvement of coronary artery function, left ventricular deformation and twisting by IL12/23 compared to TNF-a inhibition in psoriasisP1160Advanced glycation end products play a role in adverse LV remodeling following MIP1161Incidence of subclinical myocardial dysfunction in patients with systemic sclerosis and normal left ventricular systolic and diastolic functionP1162Left atrial remodeling and dysfunction occur early in patients with systemic sclerosis and normal left ventricular functionP1163Intrinsic vortex formation : a unique performance indicatorP1164P-wave morphology is unaffected by training-induced biatrial dilatation: a prospective, longitudinal study in healthy athletesP1165Usefulness of transthoracic echocardiography in diagnosis of young patients with ischemic strokeP1166Primary cardiac lymphoma: role of echocardiography in the clinical managementP1167Abnormal echocardiographic findings in cancer patients before chemotherapyMasses, tumors and sources of embolismP1168Three-dimensional transesophageal echocardiography of the left atrial appendage reduces rate of postpone electrical cardioversionP1169Detection of ventricular thrombus by cmr after reperfused st-segment elevation myocardial infarction correlated with echocardiographyP1170Clinical and transthoracic echocardiographic predictors of left atrial appendage thrombus in patients with atrial fibrillationStress echocardiographyP1171Pharmacological stress echocardiography complications: a 4-year single center experienceP1172Myocardial functional and perfusion reserve in type I diabetesP1173Feasibility of incorporating 3D Dobutamine stress echocardiography into routine clinical practiceP1174Right ventricular isovolumic acceleration at rest and during exercise in children after heart transplantP1175Right ventricular systolic and diastolic response to exercise in children after heart transplant -a bicycle exercise studyP1176Determinants of functional capacity in heart failure patients with reduced ejection fractionP1177Handgrip stress echocardiography with emotional component compared to conventional isometric exercise in coronary artery disease diagnosisP1178The relationship between resting transthoracic echocardiography and exercise capacity in patients with paroxysmal atrial fibrillationP1179Correlation between NT-proBNP and selected echocardiography parameters at rest and after exercise in patients with functional ischemic mitral regurgitation qualified for cardiosurgical treatmentReal-time three-dimensional TEEP1180Vena contracta area for severity grading in functional and degenerative mitral regurgitation: A study based on transesophageal 3D colour Doppler in 419 patientsP1181Proximal flow convergence by 3D echocardiography in the evaluation of mitral valve area in rheumatic mitral stenosisP1182Quantification of valve dimensions by transesophageal 3D echocardiography in patients with functional and degenerative mitral regurgitationTissue Doppler and speckle trackingP1183Automatic calculation of left ventricular volume changes over a cardiac cycle from echocardiography images by nonlinear dimensionality reductionP1184Effect of the mitral valve repairs on the left ventricular blood flow formationP1185Quantification of left atrial strain using cardiovascular magnetic resonance. a comparison between hypertrophic cardiomyopathy and healthy controlsP1186The role of early systolic lengthening in patients with non-ST elevation acute coronary syndrome and its relation to syntax scoreP1187Different standard two dimensional strain methods to quantity left ventricular mechanicsP1188Atrial function and electrocardiography caracteristics in sportsmen with or without paroxysmal atrial fibrillationP1189Right ventricular outflow premature contractions induce regional left ventricular dysfunctionP1190Ultrasound guided venous access for pacemaker and defibrillators. Randomized TrialP1191Atrial function analysis correlates with symptoms and quality of life of heart failure patientsP1192The use of tissue doppler echocardiography in myocardial iron overload in patients with thalassaemia majorP1193Independent association between pulse pressure and left ventricular global longitudinal strainP1194Global and regional longitudinal strain identifies the presence of coronary artery disease in patients with suspected reduction of coronary flow reserve and absence of wall motion abnormalitiesP1195Prognostic value of invasive and noninvasive parameters of right ventricular function in patients with pulmonary arterial hypertension receiving specific vasodilator therapyP1196Myocardial deformation analysis to improve arrhythmic risk stratificationP1197Quantitative assessment of regional systolic and diastolic function parameters for detecting prior transient ischemia in normokinetic segmentsP1198Left atrial function in patients with corrected tetralogy of Fallot - a three-dimensional speckle-tracking echocardiographic studyP1199Left atrial ejection force correlates with left atrial strain and volume-based functional properties as assessed by three-dimensional speckle tracking echocardiographyP1200Acute angulation of the aortic arch late after the arterial switch operation for transposition of the great arteries: impact on cardiac mechanicsP1201Circumferential deformation of the ascending thoracic aorta in hypertensive patients by three-dimensional speckle tracking echocardiographyCardiac Magnetic ResonanceP1202The incremental value of cardiac magnetic resonance on diagnosis myocardial infarction and non-obstructed coronary arteriesP1204Reference ranges of global and regional myocardial T1 values derived from MOLLI and shMOLLI at 3TComputed Tomography & Nuclear CardiologyP1205Deformation of the left atrial appendage after percutaneous closure with the Amplatzer cardiac plugP1206Prognostic impact of non-obstructive coronary artery disease on coronary computed tomographic angiography: A single-center study
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B Jug, X Iriart, A M Maceira Gonzalez, P Caravaca, L Capotosto, G Di Salvo, A Nemes, K Wdowiak-Okrojek, G Novo, R Enache, C Goffredo, M Lembo, E Ako, M Cameli, M Liccardo, OA Enescu, A Hubert, S Ranjbar, T Unkun, G Alonso Salinas, M Karvandi, B Goebel, R Ladeiras-Lopes, J Kochanowski, JJ Van Zalen, VA Kuznetsov, F Bandera, B Cifra, R Aghamohammadzadeh, B Shivalkar, J F Carvalho, K Kupczynska, E Cambronero Cortinas, O Tereshina, O Gonzalez Fernandez, P Sormani, C Ferrera Duran, F D'ascenzi, GJ King, D Peluso, V Ferferieva, I Ikonomidis, J Mesquita, MV Krestjyaninov, K Domingues, L Reis, B F Lourenco Marmelo, F Tarando, J Y Cho, M Kubik, M Mielczarek, A R Godinho, D H F Gommans, C De Gregorio, M Marchel, D M Raafat, F Ancona, G Tamborini, D Fasano, O De Diego Soler, P Aruta, G Palmiero, AAM Farrag, R Zilberszac, S A Gao, M Santos, T E Chalbia, YJ Lim, A Borowiec, K Gillis, I Fabiani, C Marini, M S Qasem, S T Roos, A Sirtautas, G Nucifora, R Acar, G Krljanac, G Pontone, A Azoz, M Mandour Ali, R Sattarzadeh Badkoubeh, A De La Rosa Riestra, E Wellnhofer, V Illatopa, K Smarz, M Cikes, S F De Marchi, A Shetye, JH Park, A B Reid, D Rodriguez Munoz, M G Andreassi, A Toth, M Chinali, P G Dinis, A Angelis, C Gonzalez Matos, S Colunga Blanco, A Garcia Campos, E Capin Sampedro, C Corros Vicente, M Martin Fernandez, V Leon Arguero, A Fidalgo Arguelles, E Velasco Alonso, F Lopez Iglesias, JM De La Hera Galarza, M Chaparro-Munoz, A Recio-Mayoral, C Vlachopoulos, N Ioakeimidis, I Felekos, M Abdelrasoul, K Aznaouridis, C Chrysohoou, G Rousakis, K Aggeli, D Tousoulis, AC Faustino, L Paiva, A Fernandes, M Costa, MC Cachulo, L Goncalves, F Emma, G Rinelli, C Esposito, A Franceschini, A Doyon, F Raimondi, F Schaefer, G Pongiglione, MC Mateucci, H Vago, C Juhasz, C Janosa, V Oprea, OH Balint, A Temesvari, T Simor, K Kadar, B Merkely, R M Bruno, A Borghini, F Stea, L Gargani, A Mercuri, R Sicari, E Picano, C Lozano Granero, A Carbonell San Roman, JL Moya Mur, C Fernandez-Golfin, J Moreno Planas, S Fernandez Santos, E Casas Rojo, A Hernandez-Madrid, JL Zamorano Gomez, K Pearce, W Gamlin, C Miller, M Schmitt, IW Seong, KH Kim, MJ Kim, HO Jung, IS Sohn, SM Park, GY Cho, JO Choi, SW Park, SA Nazir, JN Khan, A Singh, P Kanagala, I Squire, GP Mccann, D Di Lisi, MC Meschisi, V Brunco, G Badalamenti, E Bronte, A Russo, S Novo, M Von Tscharner, S Urheim, S Aakhus, C Seiler, S Schmalholz, T Biering-Sorensen, S Cheng, S Oparil, J Izzo, B Pitt, SD Solomon, B Zaborska, T Jaxa-Chamiec, M Tysarowski, A Budaj, F Cordova, O Aguirre, S Sanabria, J Ortega, G Romeo, M Perazzolo Marra, F Tona, G Famoso, E Pigatto, F Cozzi, S Iliceto, LP Badano, C Kriatselis, JH Gerds-Li, M Kropf, B Pieske, M Graefe, P Martinez Santos, E Batlle Lopez, I Vilacosta, B Sanchez Sauce, E Espana Barrio, J Jimenez Valtierra, R Campuzano Ruiz, J Alonso Bello, MD Martin Rios, M Farrashi, H Abtahi, H Sadeghi, P Sadeghipour, A Tavoosi, TA Abdel Rahman, LA Mohamed, HM Maghraby, IM Kora, FR Abdel Hameed, MN Ali, A Al Shehri, A Youssef, A Gad, M Alsharqi, L Alsaikhan, D Andreini, C Rota, M Guglielmo, S Mushtaq, A Baggiano, V Beltrama, A Solbiati, AI Guaricci, M Pepi, D Trifunovic, D Sobic Saranovic, L Savic, I Grozdic Milojevic, M Asanin, M Srdic, M Petrovic, N Zlaic, I Mrdovic, C Dogan, S Izci, C Gecmen, M Cap, E Erdogan, C Onal, F Yilmaz, N Ozdemir, D Muser, C Tioni, D Zanuttini, G Morocutti, L Spedicato, G Bernardi, A Proclemer, R Pranevicius, N Zapustas, K Briedis, Z Valuckiene, R Jurkevicius, LJM Juffermans, V Enait, N Van Royen, AC Van Rossum, O Kamp, HASSEN Khalaf, SAKER Hitham, AS Osama, RAMI Abazid, RAHIM Guall, SHAFAT Durdan, ZYAD Mohammed, S Stella, I Rosa, M Spartera, L Italia, A Latib, A Colombo, A Margonato, E Agricola, C Scatena, C Mazzanti, L Conte, N Pugliese, V Barletta, U Bortolotti, AG Naccarato, V Di Bello, G Bala, B Roosens, S Hernot, I Remory, S Droogmans, B Cosyns, G Generati, V Labate, V Donghi, M Pellegrino, F Carbone, E Alfonzetti, M Guazzi, R Dabrowski, I Kowalik, B Firek, T Chwyczko, H Szwed, A Kawamura, S Kawano, A Zaroui, R Ben Said, M Ben Halima, N Kheder, A Farhati, S Mourali, R Mechmech, L Leite, R Martins, R Baptista, A Barbosa, N Ribeiro, A Oliveira, G Castro, M Pego, C L Polte, K Lagerstrand, Å A Johnsson, M Janulewicz, O Bech-Hanssen, H Gabriel, W Wisser, G Maurer, R Rosenhek, W El Aroussy, M Abdel Ghany, K Al Adeeb, L Ascione, G Carlomagno, C Sordelli, A Ferro, R Ascione, S Severino, P Caso, D Muraru, C Janei, M Haertel Miglioranza, G Cavalli, U Cucchini, L Badano, X Armario Bel, C Garcia-Garcia, E Ferrer Sistach, F Rueda Sobella, T Oliveras Vila, C Labata Salvador, J Serra Flores, J Lopez-Ayerbe, A Bayes-Genis, E Conte, A Gonella, L Morena, D Civelli, L Losardo, F Margaria, L Riva, M Tanga, C Carminati, M Muratori, P Gripari, S Ghulam Ali, L Fusini, C Vignati, AL Bartorelli, F Alamanni, M Montorfano, A Ismaiel, N Ali, S Amry, A Serafin, KJ Filipiak, G Opolski, G Speranza, G Ando', L Magaudda, GE Cramer, J Bakker, M Michels, HJ Dieker, MA Fouraux, CLM Marcelis, J Timmermans, MA Brouwer, MJM Kofflard, M Vasconcelos, V Araujo, P Almeida, C Sousa, F Macedo, JS Cardoso, MJ Maciel, D Voilliot, O Huttin, C Venner, A Olivier, T Villemin, R Deballon, V Manenti, Y Juilliere, C Selton-Suty, A Dabrowska-Kugacka, K Dorniak, E Lewicka, D Szalewska, M Kutniewska-Kubik, G Raczak, K H Kim, H J Yoon, H J Park, Y Ahn, M H Jeong, J G Cho, J C Park, J H Kim, E Galli, G Habib, F Schnell, M Lederlin, JC Daubert, P Mabo, E Donal, R Faria, P Magalhaes, N Marques, C Lourenco, AR Almeida, L Teles, B Picarra, O Azevedo, M Oliveira, B Marmelo, A Almeida, D Bento, I Cruz, RH Gimaev, MA Melnikova, NV Olezov, VI Ruzov, P Goncalves, M S Almeida, P Branco, M S Carvalho, H Dores, M A Gaspar, H Sousa, M J Andrade, M Mendes, G Makavos, M Varoudi, E Papadavid, I Andreadou, K Gravanis, N Liarakos, G Pavlidis, D Rigopoulos, J Lekakis, D Deluyker, V Bito, L Punzi, T Neilan, K Coen, S Gannon, K Bennet, JG Clarke, M Solari, M Focardi, D Corrado, M Bonifazi, M Henein, S Mondillo, C Gomez-Escalonilla, A De Agustin, J Egido, F Islas, P Simal, JJ Gomez De Diego, M Luaces, C Macaya, L Perez De Isla, M Zancanella, C Rusconi, F Musca, G Santambrogio, B De Chiara, P Vallerio, R Cairoli, G Giannattasio, A Moreo, C Alvarez Ortega, R Mori Junco, J Caro Codon, P Meras Colunga, I Ponz De Antonio, T Lopez Fernandez, S Valbuena Lopez, M Moreno Yanguela, JL Lopez-Sendon, E Surkova, C Bonanad-Lozano, MP Lopez-Lereu, JV Monmeneu-Menadas, J Gavara, E De Dios, A Paya-Chaume, D Escribano-Alarcon, FJ Chorro-Gasco, V Bodi-Peris, BW Michalski, D Miskowiec, JD Kasprzak, P Lipiec, G Morgado, D Caldeira, I Joao, A R Almeida, L Lopes, P Fazendas, C Cotrim, H Pereira, C De Block, D Buys, R Salgado, C Vrints, L Van Gaal, C Mctear, RB Irwin, A Dragulescu, M Friedberg, L Mertens, DV Krinochkin, EI Yaroslavskaya, EH Zaharova, GS Pushkarev, C Sugihara, NR Patel, AN Sulke, GW Lloyd, R Piatkowski, P Scislo, M Grabowski, H Roland, A Hamadanchi, S Otto, C Jung, A Lauten, HC Figulla, TC Poerner, F Sampaio, P Fonseca, R Fontes-Carvalho, M Pinho, AS Campos, P Castro, C Fonseca, J Ribeiro, V Gama, R Heck, A Hamdanchi, HR Figulla, M Ghaffaripour Jahromi, R Hinojar, C Fernandez Golfin, A Esteban, M Pascual-Izco, A Garcia-Martin, JJ Jimenez-Nacher, JL Zamorano, RB Bakal, C Kaymaz, V Galand, D Matelot, C Leclercq, F Carre, BC Suran, AD Margulescu, RC Rimbas, C Siliste, D Vinereanu, P Nocerino, AC Urso, A Borrino, C Carbone, P Follero, C Ciardiello, L Prato, G Salzano, F Marino, A Ruspetti, S Sparla, C Di Tommaso, F Loiacono, J Porter, M Walker, F Lo Iudice, R Esposito, C Santoro, S Cocozza, R Izzo, N De Luca, G De Simone, B Trimarco, M Galderisi, F Gervasi, G Patti, S Mega, M Bono, G Di Sciascio, A Buture, R Badea, P Platon, I Ghiorghiu, R Jurcut, IM Coman, BA Popescu, C Ginghina, M Lunetta, MS Spoto, AM Lo Vi, G Pensabene, P Carita, G Coppola, P Assennato, A Shim, P Wejner-Mik, K Havasi, P Domsik, A Kalapos, T Forster, GA Piros, C Lengyel, A Orosz, Z Bulbul, Z Issa, A Al Sehly, V Pergola, S Oufi, Y Conde, E Cimino, E Rinaldi, R Ashurov, S Ricci, M Pergolini, A Vitarelli, JE Lujan Valencia, M Chaparro, A Garcia-Guerrero, MJ Cristo Ropero, A Izquierdo Bajo, L Madrona, JV Monmeneu, B Igual, P Lopez Lereu, MP Garcia, W Selmi, Z Jalal, JB Thambo, D Kosuta, and Z Fras
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medicine.medical_specialty ,business.industry ,General Medicine ,medicine.disease ,medicine.anatomical_structure ,St elevation myocardial infarction ,Internal medicine ,Mitral valve ,medicine ,Cardiology ,Radiology, Nuclear Medicine and imaging ,Myocardial infarction ,Mitral annulus ,Cardiology and Cardiovascular Medicine ,Ventricular remodeling ,business - Published
- 2015
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23. P16 ink4A, p53 alterations and S phase fraction are predictive of clinical outcome in laryngeal squamous cell carcinoma
- Author
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S CORSALE, V AGNESE, C AUGELLO, L BRUNO, D CALCARA, V CALO', G GARGANO, V GREGORIO, GULLO A, L LA PAGLIA, SCHIRO' V, M TERRASI, G RINALDI, A CROSTA, G BADALAMENTI, V MORELLO, RM TOMASINO, E DANIELE, A GERBINO, M BUSCEMI, GA CHIARINI, A MARTORANA, V BAZAN, A RUSSO, S CORSALE, V AGNESE, C AUGELLO, L BRUNO, D CALCARA, V CALO', G GARGANO, V GREGORIO, GULLO A, L LA PAGLIA, SCHIRO' V, M TERRASI, G RINALDI, A CROSTA, G BADALAMENTI, V MORELLO, RM TOMASINO, E DANIELE, A GERBINO, M BUSCEMI, GA CHIARINI, A MARTORANA, V BAZAN, and A RUSSO
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LARYNGEAL, CELL CARCINOMA - Published
- 2006
24. MidMedPol: Polychaetes from midlittoral rocky shores in Greece and Italy (Mediterranean Sea)
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Keklikoglou, K. Faulwetter, S. Chatzigeorgiou, G. Badalamenti, F. Spyridon, M. Arvanitidis, C.
- Abstract
This paper describes a dataset of polychaetes (Annelida) from 14 midlittoral rocky shore sampling sites in Greece and Italy (Mediterranean Sea). The dataset combines the outcome of four different projects studying the hard substrate midlittoral zone in the Mediterranean between 1984 and 2009. Samples were collected by scraping and collecting the organisms from a framed area. The maximal sampling depth was 1.5 m. In total, 123 polychaete species were recorded, five of which are new records for the respective biogeographic sectors of the Mediterranean. The dataset contains 788 occurrence records, fully annotated with all required metadata. These data contribute to the knowledge of a previously very understudied regional habitat, since at present, comprehensive lists of the midlittoral communities in the Mediterranean are provided through only a few, paper-based, studies. This dataset is one of the first electronic data compilations of the Mediterranean midlittoral zone communities and certainly the most comprehensive of its kind, contributing to the ongoing efforts of the Ocean Biogeographic Information System (OBIS) which aims at filling the gaps in our current knowledge of the world's oceans. It is accessible at http://ipt.vliz.be/resource.do? r=mediterraneanpolychaetaintertidal. © Keklikoglou K et al.
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- 2013
25. Integrated optic Surface Plasmon Resonance Measurements in Glass substrates
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Alessandro Busacca, Luciano Curcio, S. Riva Sanseverino, Alfonso Carmelo Cino, E. D'Asaro, Saverio Guarino, Antonino Parisi, Fedele D'Aleo, G. Badalamenti, PARISI A, DALEO F P, GUARINO S, CURCIO L, BADALAMENTI G, CINO AC, BUSACCA AC, DASARO E, and RIVA-SANSEVERINO S
- Subjects
Fabrication ,Optics ,Fiber optic sensor ,business.industry ,Chemistry ,Surface plasmon ,Surface plasmon resonance ,Thin film ,business ,Biosensor ,Waveguide (optics) ,Refractive index - Abstract
The surface plasmon resonance (SPR) technique is an optical method that can be used to measure the refractive index of organic nano-layers adsorbed on a thin metal film. Although there are many techniques for measuring biomolecular interactions, SPR-based techniques play a central role in many current biosensing experiments, since they are most suited to sensitive and quantitative kinetic measurements. Here we give some results from the analysis and numerical elaboration of SPR data regarding the flow of different solutions with refractive indexes in the range of interest (1-1.4). After a brief discussion of the principles of SPR and of waveguide fabrication technique, we give a description of system setup and some results regarding the real time waveguide output intensity monitoring to measure the interaction between the gold thin film and the analyte.
- Published
- 2007
26. Tumor markers in urogynaecological tumors
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G, Leto, L, Incorvaia, G, Badalamenti, C, Arcara, F, Fulfaro, F M, Tumminello, C, Flandina, M, Crescimanno, and N, Gebbia
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Diagnosis, Differential ,Immunoenzyme Techniques ,Proteomics ,Biomarkers, Tumor ,Radioimmunoassay ,Humans ,Sensitivity and Specificity ,Urogenital Neoplasms - Published
- 2006
27. Weekly paclitaxel and Pegylated liposomal doxorubicin as first line treatment in metastatic breast cancer patients
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F. Fulfaro, M. R. Valerio, G. Badalamenti, C. Arcara, G. Cicero, C. Intrivici, A. Crosta, C. Sciortino, A. Russo, N. Gebbia, FULFARO F, VALERIO MR, and BADALAMENTI G
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Cancer Research ,Oncology - Abstract
Background: Paclitaxel-Doxorubicin combination chemotherapy is highly active in metastatic breast cancer patients (pts) but may be cardiotoxic in a small percentage of cases. PLD is a new formulation of Doxorubicin with significant reduced cardiac toxicity and for this reason PLD can be given safe in elderly patients with cardiac risk factors or in younger patients with prior exposure to anthracycline-containing regimens. The main side effect of PLD is Hand-Foot syndrome but when given in intervals not below 4 weeks and with a dose intensity not exceeding 10 mg/sqm per week, this side effects is clearly reduced. Methods: : We carried out a phase 2 study to verify the activity of P 70 mg/sm weekly day 1–8-15 and PLD 30 mg/mq every four weeks. Inclusion Criteria were: age 12months) or patients with LVEF beetween 40–50%, informed consent. Results: Out of the 11 patients so far included, 9 were evaluable for toxicity and response. Five patients (55.5%) showed a response including 4 PR and 1 CR, 1 patients (11.1 %) obtained SD and 2 pts (33.3%) progressed. Median time to progression and median survival have to be reached. Haematological side effects were: Neutropenia G1–2 in 4 pts (44.4%), thrombocytopenia G1–2 in 3 pts (33.3%). The non-haematological side effects were mild with the total absence of grade 3–4 toxicities. Only 3 patients (33.3%) experienced grade 2 nausea and stomatitis. G1–2 peripheral sensory neuropathy was seen in 1 pt (11.1%). Hand-Foot syndrome G1–2 occurred in 2 pts (22.2%). Conclusions: The treatment with weekly Paclitaxel and PLD with this schedule appears to be a well tolerated therapy with an interesting activity in this subset of patients.
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- 2004
28. A phase 2 study of oxaliplatin (O) -capecitabine (C) chemotherapy in metastatic breast cancer (MBC) patients pretreated with anthracyclines and taxane
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N. Gebbia, F. Fulfaro, G. Badalamenti, C. Arcara, G. Cicero, G. Rinaldi, L. Vizzini, F. Spinnato, A. Russo, and M. R. Valerio
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Cancer Research ,Oncology - Published
- 2004
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29. Role of Complement in Nephrotoxic Nephritis
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N. S. Cooper, G. Badalamenti, and A. Taranta
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Ovalbumin ,Biology ,Kidney ,Serology ,Antigen-Antibody Reactions ,Glomerulonephritis ,Immune system ,medicine ,Animals ,Antiserum ,Nephritis ,Multidisciplinary ,Tissue Extracts ,Research ,Gamma globulin ,Complement System Proteins ,medicine.disease ,Pepsin A ,Rats ,Proteinuria ,Metabolism ,medicine.anatomical_structure ,Immunology ,biology.protein ,Rabbits ,gamma-Globulins ,Antibody - Abstract
AN immunological mechanism has been postulated to explain some features of human glomerulonephritis1. In acute glomerulonephritis in man and in the acute stage of experimental nephrotoxic (Masugi) nephritis the level of serum complement (C′) drops2,3 and C′ has been demonstrated in the kidney lesions by immuno-fluorescent techniques4,5. Since C′ is a lytic agent for some bacteria and for isolated mammalian cells ‘sensitized’ by specific antibodies, the question arises whether C′ plays an active or an incidental part in these kidney lesions. The evidence in favour of an active role is, as yet, only circumstantial, since C′ is bound in serological reactions not only when it is necessary for them, as in immune lysis, but also when it is not, as in agglutination or precipitation. More pertinent is the observation that avian antisera, reportedly poor complement fixers, usually cause nephrotoxic nephritis only after a latent period of several days, while rabbit antisera can cause it immediately6. The delayed nephritis has been ascribed to the rat's own antibodies against the heterologous anti-kidney anti-bodies, localized in kidneys. However, this comparison between avian and rabbit antisora is of dubious validity because of our ignorance of the serological specificity of those antisera (which may or may not be identical) as well as of their antibody content (which is usually compared only on the basis of their nephrotoxic effect—the very variable under investigation).
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- 1963
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30. Electron microscopy, autoradiography and the soluble iodoproteins in simple goiter
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M, Andreoli, M, Negri, A, Lupulescu, F, Monaco, and G, Badalamenti
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Iodine Radioisotopes ,Microscopy, Electron ,Goiter ,Autoradiography ,Humans ,Proteins ,Iodoproteins ,Iodine - Published
- 1967
31. [The incidence of cardiac changes in a group of gouty patients]
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M, Giacovazzo, G, Spagna, and G, Badalamenti
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Adult ,Electrocardiography ,Gout ,Rheumatic Heart Disease ,Humans ,Middle Aged ,Aged - Published
- 1969
32. [Research on total and partial gastrointestinal transit times]
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C C, Cassano, M, Amoruso, P, Arullani, and G, Badalamenti
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Colonic Diseases ,Chromium Isotopes ,Humans ,Polyethylenes ,Gastrointestinal Motility - Published
- 1967
33. [Changes in the synovial fluid and tissue following treatment with Au 198 in rheumatoid synovitis of the knee]
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L, Schiavetti, G, Badalamenti, G, Merola, F, Porzio, T, Tuzi, and I, Caruso
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Arthritis, Rheumatoid ,Gold Colloid, Radioactive ,Male ,Synovitis ,Knee Joint ,Synovial Fluid ,Synovial Membrane ,Humans ,Female - Published
- 1970
34. [Testicular biopsy: immunological research]
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R, De Santis, G, Badalamenti, A, Legramante, and M, Re
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Antigen-Antibody Reactions ,Male ,Biopsy ,Freund's Adjuvant ,Testis ,Animals ,Autoimmune Diseases ,Rats - Published
- 1966
35. [Thyroid-stimulating activity with prolonged action in the serum of rabbits immunized with human thyroid]
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A, Pinchera, P, Liberti, and G, Badalamenti
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Blood ,Animals ,Long-Acting Thyroid Stimulator ,Rabbits ,In Vitro Techniques ,Hyperthyroidism ,Antibodies - Published
- 1965
36. [Electrocardiographic alterations in anaphylactic shock in rabbits]
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V, Greco, G, Badalamenti, M, Puletti, and L, Palagi
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Electrocardiography ,Animals ,Arrhythmias, Cardiac ,Serum Albumin, Bovine ,Rabbits ,Anaphylaxis - Published
- 1966
37. [Data on the therapy of 'idiopathic rectocolitis' with immunosuppressive drugs]
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R, Caprilli, G, Badalamenti, and R, De Santis
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Adult ,Male ,Azathioprine ,Fluorescent Antibody Technique ,Humans ,Colitis, Ulcerative ,Female ,Middle Aged ,Antibodies ,Immunosuppressive Agents - Published
- 1966
38. [Experimental ischemic necrosis of the testis: immuno-histological research]
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A, Legramante, R, De Santis, M, Re, and G, Badalamenti
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Male ,Necrosis ,Ischemia ,Testis ,Animals ,Fluorescent Antibody Technique ,gamma-Globulins ,Testicular Diseases ,Antibodies ,Rats ,Skin Tests - Published
- 1966
39. [Immuno-endocrinologic criteria as a guide in corticoid therapy of infectious diseases]
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A, Ippolito, M, Giacovazzo, L A, Garufi, G, Badalamenti, and R, De Santis
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Cortisone ,Adrenal Cortex Hormones ,Humans ,Infections - Published
- 1967
40. Gastrointestinal stromal tumors (GISTs): focus on histopathological diagnosis and biomolecular features.
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G Badalamenti, V Rodolico, F Fulfaro, S Cascio, C Cipolla, G Cicero, L Incorvaia, M Sanfilippo, C Intrivici, L Sandonato, G Pantuso, MA Latteri, N Gebbia, and A Russo
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- *
GASTROINTESTINAL stromal tumors , *MESENCHYME , *TUMORS , *GROWTH factors , *IMATINIB - Abstract
Gastrointestinal stromal tumors (GISTs) are mesenchymal tumors of the gastrointestinal tract that are believed to originate from a neoplastic transformation of the intestinal pacemaker cells (interstitial cells of Cajal) normally found in the bowel wall or their precursors. Although the microscopic features have been known for a long time, the defining characteristic of GIST is the presence of the cell-surface antigen CD117 (KIT), which is demonstrated by immunohistochemistry. KIT, which is a growth factor transmembrane receptor, is the product of the proto-oncogene c-kit (chromosome 4). Surgical removal remains the only curative treatment for patients with GISTs. Tumor size, mitotic index, anatomic location, tumor rupture and disease-free interval are the classic characteristics used to predict the clinical course of patients who undergo complete gross resection. Most GISTs express constitutively activated mutant isoforms of KIT or kinase platelet-derived growth factor receptor alpha (PDGFRA) that are potential therapeutic targets for imatinib mesylate. Imatinib mesylate is a rationally designed, molecularly specific oral anticancer agent that selectively inhibits several protein tyrosine kinases central to the pathogenesis of human cancer and which has demonstrated remarkable clinical efficacy in patients with chronic myeloid leukemia and malignant GISTs. More recently Sunitinib, a new KIT/PDGFRA kinase inhibitor, has been tested in patients with GIST resistant to imatinib, with promising results. [ABSTRACT FROM AUTHOR]
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- 2007
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41. Persistance of residual vein thrombosis after an episode of deep vein thrombosis of the lower limbs and the risk of new cancer and cardiovascular disease
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Raffaela Anastasio, Giuseppe Badalamenti, C. Arcara, Ignazio Abbene, Alessandra Casuccio, M. R. Valerio, Sergio Siragusa, Fabio Fulfaro, Nicolo' Gebbia, Alessandra Malato, FULFARO F, S SIRAGUSA, R ANASTASIO, A MALATO, A CASUCCIO, C ARCARA, G BADALAMENTI, M VALERIO, I ABBENE, and N GEBBIA
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First episode ,Cancer Research ,medicine.medical_specialty ,business.industry ,Incidence (epidemiology) ,Deep vein ,Cancer ,Disease ,medicine.disease ,Gastroenterology ,Thrombosis ,Surgery ,medicine.anatomical_structure ,Oncology ,Internal medicine ,medicine ,cardiovascular diseases ,Risk factor ,Prospective cohort study ,business - Abstract
8531 Background: In patients with a first episode of idiopathic or provoked Deep Vein Thrombosis (DVT), the presence of Residual Vein Thrombosis (RVT), detected by UltraSonography (US) at the 3rd month from the index DVT, is an independent risk factor for developing recurrent Venous Thromboembolism (VTE) in the subsequent 2 years. Its absence can safely permit to stop Oral Anticoagulants (OA). At the present, it is unknown whether RVT may also identify patients at increased risk for developing cancer and/or cardiovascular disease (CD). In patients with previous DVT of the lower limbs, we conducted a prospective study for evaluating the correlation between RVT findings and the risk of new cancer and/or CD. Methods: Three hundred-forty-five patients, with a previous episode of idiopathic or provoked DVT, were evaluated; presence/absence of RVT was detected at the 3rd month of OA and patients managed consequently. In the present study, the incidence of VTE recurrence, cancer and new CD was evaluated in the subsequent 3 years after the index DVT. The Kaplan-Meyer curve and the Breslow test has been used for the statistical comparison among groups. Results: The results among the 3 groups are listed in the Table. Patients without RVT had a significant reduction in recurrent VTE and new cancer in comparison to patients with RVT; they also showed a not significant trend in the reduction of CD; these data are applicable in patients with idiopathic or provoked index DVT. In patients with RVT, the advantage of prolonging anticoagulation over 12 months (Group A1) is lost at the end of the treatment. Conclusions: US-detected RVT, at 3rd month from the index DVT, is an independent risk factor for recurrent VTE and cancer; this risk remains over a period of 3 years, independently whether index DVT was idiopathic or provoked. In these patients, the advantage of indefinite anticoagulation should be assessed in properly designed study. [Table: see text] No significant financial relationships to disclose.
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- 2006
42. Activin A circulating levels in Patients with primary osteoporosis or bone metastases from brest cancer
- Author
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INCORVAIA, Lorena, SFERRAZZA, Carmela, DI LORENZO, Gabriele, G. DI FEDE, BADALAMENTI, Giuseppe, G. ROTOLO, S. FRICANO, LETO, Gaetano, N. GEBBIA AND GB RINI, L INCORVAIA, C SFERRAZZA, G DI FEDE, G BADALAMENTI, G ROTOLO, S FRICANO, G DI LORENZO, LETO G, and N GEBBIA AND GB RINI
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- 2005
43. A phase II study of oxaliplatin (O) and gemcitabine (G) first line chemotherapy in patients with advanced biliary tract cancers
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Nicolo' Gebbia, D. Santangelo, M. R. Valerio, Ignazio Carreca, Giuseppe Badalamenti, R. Di Leo, C. Arcara, Francesco Verderame, Giuseppe Cicero, Fabio Fulfaro, N GEBBIA, F VERDERAME, R DI LEO, D SANTANGELO, G CICERO, M R VALERIO, C ARCARA, G BADALAMENTI, F FULFARO, and CARRECA I
- Subjects
Oncology ,Cancer Research ,Chemotherapy ,medicine.medical_specialty ,business.industry ,medicine.medical_treatment ,Phases of clinical research ,Disease ,Gemcitabine ,Oxaliplatin ,Biliary tract ,Internal medicine ,Medicine ,In patient ,First line chemotherapy ,business ,medicine.drug - Abstract
Background: Biliary tract cancers are uncommon tumors with a poor prognosis and most patients (pts) present with invasive and inoperable disease at diagnosis. Chemotherapy represents a palliative treatment, but single or combination-drug schedules have demonstrated poor response rates with a median survival less than 6 months. Recently O and G have showed an interesting activity as single agents in this group of pts. Methods: We carried out a multicenter phase II study to evaluate the efficacy and safety of combined O and G in locally advanced and metastatic biliary tract carcinoma. The schedule of chemotherapy included O 100 mg/m2 on day 1 and G 1000 mg/m2 on days 1 and 8, every 21 days. Inclusion Criteria were: histological diagnosis of biliary tract carcinoma, age
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- 2005
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44. Bisphosphonate-related osteonecrosis of the jaw (BRONJ): run dental management designs and issues in diagnosis.
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G Campisi, O Di Fede, A Musciotto, A Lo Casto, L Lo Muzio, F Fulfaro, G Badalamenti, A Russo, and N Gebbia
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BONE diseases , *DIPHOSPHONATES , *DRUG side effects , *METASTASIS , *CANCER patients - Abstract
Recently, jawbone osteonecrosis has been largely reported as a potential adverse effect of bisphosphonate (BP) administration. Because of the peculiar pharmacokinetic and pharmacodynamic features of the BF (mainly for i.v. administration), their efficacy and large use, some major issues have to be taken into account extendedly both by oncologists and by dentists: 1) therapeutic dental protocol for patients with diagnosis of bisphosphonate-related osteonecrosis of the jaw (BRONJ); 2) dental strategies for patients in former or current i.v. BF treatment and in absence of BRONJ signs; 3) strategies for patients before i.v. BF treatment. Clinical features and guidelines for the management of this condition have been investigated and reported, sometimes with unclear indications; hence, on the basis of the literature and our clinical experience, major end points of this paper are providing our run protocols for the issues above described and, finally, focusing on a crucial, but not extensively investigated point: the early and correct diagnosis of BRONJ versus metastatic jaw lesions in cancer patients. [ABSTRACT FROM AUTHOR]
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- 2007
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45. The role of Aurora-A inhibitors in cancer therapy.
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V Agnese, V Bazan, FP Fiorentino, D Fanale, G Badalamenti, G Colucci, V Adamo, D Santini, and A Russo
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- *
DRUG therapy , *MITOSIS , *PROTEINS , *PHOSPHORYLATION , *ONCOGENES - Abstract
Recently, new chemotherapy agents which target the non-structural components of mitosis have been developed. An important protein involved in several mitotic phases is the Aurora-A protein. By means of the phosphorylation of different substrates, Aurora-A regulates the correct development of the various phases of mitosis. The kinase activity of this protein makes Aurora-A an excellent candidate as an oncogene. The first data of Aurora-A involvement in cancer regarded the identification of Aurora-A overexpression in primary breast and colon tumour samples. With regard to the predictive role of Aurora-A, it has been shown that its overexpression disrupts the spindle checkpoint activated by paclitaxel (Taxol) or nocodazole treatment, thus inducing the cells to become resistant to these drugs. The development therefore of small molecules with an Aurora-A inhibition function may make it possible to reduce or block the oncogenic activity of Aurora-A and in addition may improve the survival of oncological patients showing resistance to paclitaxel or nocodazole treatment. Three novel Aurora kinase inhibitors have recently been described—Hesperadin, ZM447439 and VX-680. All these three drugs have been designed to target the ATP-binding site of Aurora kinase, so they inhibit all three Aurora kinase family members showing a similar phenotype when tested in cell-based assays. Among these three different molecules, VX-680 has shown promising results in in vitro and in vivo studies. In conclusion, it is clear that we are entering a new era in anti-mitotic therapy with the identification and now clinical translation of new targets in mitosis beyond tubulin but many questions remain with regard to Aurora function. [ABSTRACT FROM AUTHOR]
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- 2007
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46. Founder mutations in BRCA1 and BRCA2 genes.
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R Ferla, V Calò, S Cascio, G Rinaldi, G Badalamenti, I Carreca, E Surmacz, G Colucci, V Bazan, and A Russo
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- *
BREAST cancer , *OVARIAN cancer , *TUMOR suppressor genes , *GENETIC mutation , *GENETIC counseling - Abstract
BRCA1 and BRCA2 germline mutations contribute to a significant number of familial and hereditary breast and/or ovarian cancers. The proportion of high-risk families with breast and/or ovarian cancer cases due to mutations in these tumor suppressor genes varies widely among populations. In some population, a wide spectrum of different mutations in both genes are present, whereas in other groups specific mutations in BRCA1 and BRCA2 have been reported with high frequency. Most of these mutations are prevalent in restricted populations as consequence of a founder effect. The comparison of haplotypes between families with the same mutation can distinguish whether high-frequency alleles derive from an older or more recent single mutational event or whether they have arisen independently more than once. Here, we review some of the most well-known and significant examples of founder mutations in BRCA genes found in European and non-European populations. In conclusion, the identification of the ethnic group of families undergoing genetic counseling enables the geneticist and oncologist to make more specific choices, leading to simplify the clinical approach to genetic testing carried out on members of high-risk families. Futhermore, the high frequency of founder mutations, allowing to analyze a large number of cases, might provide accurate information regarding their penetrance. [ABSTRACT FROM AUTHOR]
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- 2007
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47. 4843delC of the BRCA1 gene is a possible founder mutation in Southern Italy (Sicily).
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A Russo, V Calò, C Augello, L Bruno, V Agnese, V Schirò, F Barbera, S Cascio, E Foddai, G Badalamenti, C Intrivici, M Cajozzo, G Gulotta, E Surmacz, G Colucci, N Gebbia, and V Bazan
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GENETIC mutation , *GENES , *CANCER cells , *NUCLEOTIDES - Abstract
Background: The frequency and the type of BRCA1 mutations vary widely and might have different geographic and ethnic distribution. Most of these alterations are generally found in isolated populations as a consequence of the founder effect. The object of this study was to determine whether 4843delC, a deleterious mutation of the BRCA1 gene, might be due to a founder effect originating in the Sicilian region of Italy. This mutation was described by us for the first time and identified in two unrelated Sicilian families with hereditary breast/ovarian cancer. The two families were from the same geographical area (south-western area of Palermo, Sicily). The homogeneity of the ethnic group of the two families and the Single Nucleotide Polymorphism (SNPs) analysis of probands led us to perform a study of the allelotype of the various members. Patients and methods: The analysis of the haplotype of the probands and of several family members was conducted by means of a study of the highly polymorphic microsatellites within or flanking the BRCA1 gene. Results: This analysis revealed the presence of a common allele associated with the mutation. Conclusions: We therefore conclude that 4843delC of the BRCA1 gene is a possible founder mutation in the Sicilian population. [ABSTRACT FROM AUTHOR]
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- 2007
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48. BRCA functional domains associated with high risk of multiple primary tumors and domain-related sensitivity to olaparib: the Prometheus Study.
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Incorvaia L, Marchetti C, Brando C, Bazan Russo TD, Bono M, Perez A, Congedo L, Ergasti R, Castellana L, Insalaco L, Contino S, Gristina V, Galvano A, Fanale D, Badalamenti G, Russo A, Scambia G, and Bazan V
- Abstract
Background: Germline pathogenic variants (gPVs) in the breast cancer susceptibility gene 1/2 (BRCA1/2) genes confer high-penetrance susceptibility to breast cancer (BC) and ovarian cancer (OC). Although most female BRCA carriers develop only a single BRCA-associated tumor in their lifetime, a smaller subpopulation is diagnosed with multiple primary tumors (MPTs). The genetic factors influencing this risk remain unclear. Further, in patients with BRCA-mutated tumors, there appears to be a variability in the effectiveness of olaparib treatment., Patients and Methods: This real-world, multicenter, observational study aimed to determine whether the location of BRCA gPVs within functional domains (FDs) is associated with the development of MPTs and the magnitude of olaparib benefit. The study population comprised consecutive patients with OC who underwent hereditary cancer genetic testing between May 2015 and March 2023. MPT history was assessed based on mutated genes (BRCA1 or BRCA2) and the location of the PVs within the FDs. Clinical outcomes of olaparib first-line maintenance therapy were evaluated according to BRCA1/2 FD location., Results: The frequency of MPT history in the overall population was 13.3% (118/882), and 20.4% in the BRCA-mutated subpopulation (68/333; P < 0.001). We observed a significant association between the DNA-binding domain (DBD) FD of BRCA2 and MPT. Specifically, 55.6% of BRCA2-mutated patients with PVs in the DBD had a history of BC as a second tumor. At a median follow-up of 48.5 months (95% confidence interval 10-70 months), the 48-month progression-free survival rates were 100.0% for patients with PVs in DBD, 91.7% for those with PVs in other FDs, and 36.4% for those with PVs in the RAD51-binding domain (RAD51-BD) of BRCA2 (P = 0.01). Results in the BRCA1 cohort were not statistically significant., Conclusions: The results suggest that the location of PVs within BRCA FDs may influence the onset of multiple tumors and the benefit of olaparib in patients with BRCA-mutated OC. These findings could be relevant for cancer prevention efforts, particularly given the increasing number of cancer survivors. However, further understanding is needed before these results can inform clinical decisions., (Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved.)
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- 2025
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49. On-treatment dynamics of circulating extracellular vesicles in the first-line setting of patients with advanced non-small cell lung cancer: the LEXOVE prospective study.
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Gristina V, Bazan V, Barraco N, Taverna S, Manno M, Raccosta S, Carreca AP, Bono M, Bazan Russo TD, Pepe F, Pisapia P, Incorvaia L, Badalamenti G, Troncone G, Malapelle U, Santini D, Russo A, and Galvano A
- Abstract
Extracellular vesicle (EV) monitoring can complement clinical assessment of cancer response. In this study, patients with advanced non-small cell lung cancer (NSCLC) undergoing osimertinib, alectinib, pembrolizumab or platinum-based chemotherapy ± pembrolizumab were enrolled. EVs were characterized using Bradford assay to quantify the circulating cell-free EV protein content (cfEV), and dynamic light scattering to assess Rayleigh ratio excess at 90°, z-averaged hydrodynamic diameter and polydispersity index. A total of 135 plasma samples from 27 patients were collected at baseline (T0) and at the first radiological restaging (T1). A ∆cfEV < 20% was associated with improved median progression-free survival (mPFS) in responders versus non-responders. Specifically, cfEV responders on pembrolizumab had a significantly better mPFS (25.2 months) compared to those on chemotherapy plus pembrolizumab (6.1 months). EGFR-positive cfEV responders also experienced longer mPFS compared to cfEV non-responders (35.1 months, 95% CI: 14.9-35.5 vs. 20.8 months, 95% CI: 11.2-30.4). This study suggested that monitoring circulating EV could provide valuable insights into treatment efficacy in NSCLC, particularly for patients receiving pembrolizumab or osimertinib., (© 2025 The Author(s). Molecular Oncology published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies.)
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- 2025
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50. 18F-Fluorodeoxyglucose Uptake in PDGFRA-Mutant Gastrointestinal Stromal Tumors.
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Nigro MC, Marchetti A, Fumagalli ER, De Luca I, Bertuzzi AF, Grimaudo MS, Grignani G, D'Ambrosio L, Merlini A, Badalamenti G, Incorvaia L, Dimino A, Gasperoni S, Vincenzi B, Fanti S, Di Federico A, Campana D, Pantaleo MA, and Nannini M
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- Humans, Female, Male, Middle Aged, Retrospective Studies, Aged, Positron-Emission Tomography methods, Adult, Gastrointestinal Neoplasms diagnostic imaging, Gastrointestinal Neoplasms genetics, Gastrointestinal Neoplasms metabolism, Gastrointestinal Neoplasms pathology, Radiopharmaceuticals pharmacokinetics, Italy, Aged, 80 and over, Gastrointestinal Stromal Tumors genetics, Gastrointestinal Stromal Tumors diagnostic imaging, Gastrointestinal Stromal Tumors metabolism, Fluorodeoxyglucose F18 pharmacokinetics, Receptor, Platelet-Derived Growth Factor alpha genetics, Mutation
- Abstract
Importance: The D842V platelet-derived growth factor receptor α (PDGFRA) mutation identifies a molecular subgroup of gastrointestinal stromal tumors (GISTs), primarily resistant to standard tyrosine kinase inhibitors and with an overall more indolent behavior. Although functional imaging with 18F-fluorodeoxyglucose-labeled positron emission tomography ([18F]FDG-PET) plays a proven role in GISTs, especially in early assessment of tumor response, less is known about [18F]FDG uptake according to the GIST molecular subtypes., Objective: To evaluate the degree of [18F]FDG uptake in PDGFRA-mutant GISTs and better define the role of functional imaging in this rare and peculiar subset of GISTs., Design, Setting, and Participants: This multi-institutional retrospective cohort study involving 7 GIST reference centers in Italy included patients with PDGFRA-mutant GIST who underwent [18F]FDG-PET from January 1, 2000, to December 31, 2023. Data on the maximum standardized uptake value (SUVmax) of primary tumor or metastatic disease were collected., Exposure: PDGFRA-mutant GIST and [18F]FDG-PET., Main Outcome and Measure: The primary outcome was the degree of [18F]FDG uptake of PDGFRA-mutant GISTs, with a focus on the D842V-mutant subgroup. Secondary objectives were to assess the association between the degree of [18F]FDG uptake and main clinicopathologic features., Results: A total of 71 patients with PDGFRA-mutant GISTs were included in the analysis: 37 (52.1%) in the D842V subgroup (group A) and 34 (47.9%) in the non-D842V subgroup (group B). Additionally, 70 patients with KIT exon 11-mutant GIST served as a control group (group C). For all 141 participants, the median age at diagnosis was 59 (range, 26-89) years, and 81 patients (57.4%) were male. Overall, the median SUVmax was 4.4 (IQR, 0-10.1), while the median SUVmax for group A was 0 (IQR, 0-3.2); for group B, 3.6 (IQR, 0-5.1); and for group C, 10.1 (IQR, 5.1-13.9). The median SUVmax of PDGFRA-mutant GISTs was significantly lower than the median value of KIT exon 11-mutant GISTs (0 [IQR, 0-4.3] vs 10.1 [IQR, 5.1-14.0]; P < .001). Median [18F]FDG uptake was significantly lower in the D842V subgroup compared with the non-D842V subgroup (0 [IQR, 0-3.2] vs 3.6 [IQR, 0-5.1]; P = .02). Moreover, the triad of gastric primary tumor, tumor size greater than 10 cm, and SUVmax of 5.75 or less was associated with identification of PDGFRA-mutant GISTs., Conclusions and Relevance: In this cohort study of patients with PDGFRA-mutant GISTs, the D842V-mutant GISTs were associated with an overall lower [18F]FDG uptake compared with other GIST subgroups. Therefore, the role of functional imaging with [18F]FDG-PET in this subset of GISTs may be limited and should be further explored for its potential prognostic and predictive value.
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- 2025
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