1. Four weeks' corticosteroid inhalation does not augment maximal power output in endurance athletes
- Author
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H. Kuipers, E. van Breda, S E Overbeek, L.J.C. (Luc) van Loon, O De Hon, G A C Van't Hullenaar, Babette M Pluim, Bewegingswetenschappen, Humane Biologie, RS: NUTRIM - R3 - Chronic inflammatory disease and wasting, and RS: NUTRIM - R1 - Metabolic Syndrome
- Subjects
Adult ,Male ,Budesonide ,medicine.medical_specialty ,medicine.drug_class ,Physical Therapy, Sports Therapy and Rehabilitation ,Athletic Performance ,Placebo ,law.invention ,Young Adult ,Double-Blind Method ,Randomized controlled trial ,law ,Administration, Inhalation ,medicine ,Humans ,Orthopedics and Sports Medicine ,Power output ,biology ,Inhalation ,Athletes ,business.industry ,General Medicine ,biology.organism_classification ,Bronchodilator Agents ,Exercise Test ,Physical Endurance ,Physical therapy ,Corticosteroid ,Augment ,business ,medicine.drug - Abstract
OBJECTIVE: To assess possible ergogenic properties of corticosteroid administration. DESIGN: A balanced, double blind, placebo-controlled design was used. PARTICIPANTS: Twenty-eight well-trained cyclists and rowers. INTERVENTION: Four weeks daily inhalation of 800 microg budesonide or placebo. Main outcome measurements: The subjects performed three incremental cycle ergometer tests until exhaustion, before and after two and four weeks of placebo or budesonide administration, to measure maximal power output (Wmax). Once a week they filled in a profile of mood state (POMS) questionnaire. RESULTS: There was no significant difference in Wmax between the placebo (376+/-25 watt) and the corticosteroid group (375+/-36 watt) during the pre-intervention test, and there were no significant changes in either group after two and four weeks of intervention. No effect of the intervention on mood state was found. CONCLUSION: Four weeks of corticosteroid or placebo inhalation in healthy, well-trained athletes did not affect maximal power output or mood state. Hence no ergogenic properties of four weeks corticosteroid administration could be demonstrated, which corroborates previous studies with short-term corticosteroid administration.
- Published
- 2008
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