1. Intramuscular midazolam rapidly terminates seizures in children and adults
- Author
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G Michael Galvin, Thomas J McDONAGH, and George A Jelinek
- Subjects
business.industry ,Status epilepticus ,Emergency department ,Teaching hospital ,law.invention ,Convulsive Seizures ,law ,Anesthesia ,medicine ,Midazolam ,medicine.symptom ,Adverse effect ,Intramuscular injection ,business ,Stopwatch ,medicine.drug - Abstract
Objective: To study the efficacy of intramuscular midazolam in treating seizures. Design: On arrival, patients with seizures were treated with intramuscular midazolam, a stopwatch was started, and an intravenous line inserted. If the seizure had not stopped within six minutes, standard intravenous anticonvulsants were given. The time to cessation of the seizure was recorded. Setting: Department of Emergency Medicine, Fremantle Hospital, a busy emergency department (50,000 annual attendances, 18% children) in a general community teaching hospital. Main outcome measure: Time to cessation of fitting. Results: Thirty eight patients aged from 15 months to 89 years, were treated with intramuscular midazolam at an average dose of 0.12mg/kg (range 0.07–0.21mg/kg). The seizures terminated in all but two cases in an average time of 1minute 53 seconds overall (range 15 seconds to 6 minutes 7 seconds). In a subgroup of 15 patients with prolonged seizures of 36 minutes duration on average, the seizures ceased in a mean time of 2 minutes 41 seconds, with one failure. The latter time is likely to represent the true response time of seizures to intramuscular midazolam as some of the short‐lived seizures may have ceased spontaneously. All seven children treated with intramuscular midazolam ceased fitting. There were no adverse side effects in any patient. Conclusion: Midazolam given by intramuscular injection was shown to be rapidly effective for the control of generalised convulsive seizures, focal seizures and status epilepticus in adults and in children. This new therapy has exciting applications in the treatment of seizures in children and in the pre‐hospital setting. 1992 Australasian College for Emergency Medicine and Australasian Society for Emergency Medicine
- Published
- 2009
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