33 results on '"Głuszewska, A"'
Search Results
2. Reduction of 24-h blood pressure variability in extreme obese patients 10 days and 6 months after bariatric surgery depending on pre-existing hypertension
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Głuszewska, Anna, Gryglewska, Barbara, Gąsowski, Jerzy, Bilo, Grzegorz, Zarzycki, Bartosz, Dzieża-Grudnik, Anna, Major, Piotr, Budzyński, Andrzej, Faini, Andrea, Parati, Gianfranco, and Grodzicki, Tomasz
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- 2019
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3. Blood pressure and arterial stiffness in patients with high sodium intake in relation to sodium handling and left ventricular diastolic dysfunction status
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Cwynar, M, Gąsowski, J, Stompór, T, Bartoń, H, Wizner, B, Dubiel, M, Głuszewska, A, Królczyk, J, Franczuk, P, and Grodzicki, T
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- 2015
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4. Reduction of 24-h blood pressure variability in extreme obese patients 10 days and 6 months after bariatric surgery depending on pre-existing hypertension
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Głuszewska, A, Gryglewska, B, Gąsowski, J, Bilo, G, Zarzycki, B, Dzieża-Grudnik, A, Major, P, Budzyński, A, Faini, A, Parati, G, Grodzicki, T, Głuszewska, Anna, Gryglewska, Barbara, Gąsowski, Jerzy, Bilo, Grzegorz, Zarzycki, Bartosz, Dzieża-Grudnik, Anna, Major, Piotr, Budzyński, Andrzej, Faini, Andrea, Parati, Gianfranco, Grodzicki, Tomasz, Głuszewska, A, Gryglewska, B, Gąsowski, J, Bilo, G, Zarzycki, B, Dzieża-Grudnik, A, Major, P, Budzyński, A, Faini, A, Parati, G, Grodzicki, T, Głuszewska, Anna, Gryglewska, Barbara, Gąsowski, Jerzy, Bilo, Grzegorz, Zarzycki, Bartosz, Dzieża-Grudnik, Anna, Major, Piotr, Budzyński, Andrzej, Faini, Andrea, Parati, Gianfranco, and Grodzicki, Tomasz
- Abstract
Bariatric surgery is considered as a first line treatment in extreme obese patients to achieve a reduction in health risks. However, after surgical procedure obese patients with normal blood pressure (BP) levels still present residual risk, which may be partly related to lack of correction of BP profile and variability. Aim: To evaluate short (10 days) and mid-term (6 months) changes of mean values, profile and variability of BP after bariatric surgery in extremely obese patients with and without hypertension. Materials & methods: A follow-up of cross-sectional study was conducted in 90 obese patients (aged 41.7 ± 11.3, BMI = 46.7 ± 5.7 kg/m2), who met the eligibility criteria and underwent bariatric surgery. Each patient underwent 24-h ambulatory BP monitoring with profile and variability estimation before, 10 days and 6 months after the intervention. Results: Sixty-seven (74.4%) patients had hypertension. Significant decrease from baseline in mean values of systolic and diastolic BP in 10 days (p < .005) and 6 months (p < .005) follow-up were observed only in patients with hypertension. Moreover, only hypertensive subjects revealed significant reduction (p < 0,05) from baseline in 24-h systolic and diastolic BP weighted standard deviation and average real variability after surgical procedure. No changes were found in dipping status. Conclusions: Bariatric surgery not only decreased BP levels, but also contributed to reduction in BP variability in early period after intervention mainly in patients with pre-existing hypertension
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- 2019
5. SARC-F as a case-finding tool for sarcopenia according to the EWGSOP2. National validation and comparison with other diagnostic standards
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Małgorzata Fedyk-Łukasik, Anna Głuszewska, Tomasz Grodzicki, Barbara Gryglewska, Joanna Czesak, Ewa Klimek, Anna Skalska, Karolina Piotrowicz, Jerzy Gąsowski, and Dolores Sánchez-Rodríguez
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Male ,Sarcopenia ,Aging ,Validation study ,medicine.medical_specialty ,Population ,EWGSOP2 ,Cronbach's alpha ,Surveys and Questionnaires ,Internal medicine ,Positive predicative value ,medicine ,Humans ,education ,Geriatric Assessment ,Aged ,DXA ,education.field_of_study ,Hand Strength ,business.industry ,Clinical performance ,Gold standard (test) ,musculoskeletal system ,medicine.disease ,body regions ,Cross-Sectional Studies ,SARC-F ,Screening ,Case finding ,Female ,Original Article ,Poland ,Geriatrics and Gerontology ,business ,human activities - Abstract
Background Sarcopenia is a potentially reversible condition, which requires proper screening and diagnosis. Aims To validate a Polish version of sarcopenia screening questionnaire (SARC-F), and assess its clinical performance. Methods Cross-sectional validation study in community-dwelling subjects ≥ 65 years of age. Diagnosis of sarcopenia was based on the 2018 2nd European Working Group on Sarcopenia in Older People (EWGSOP2) consensus. Hand grip and 4-m gait speed were measured, and the Polish version of SARC-F was administered. Results The mean (SD) age of 73 participants (21.9% men) was 77.8 (7.3) years. Seventeen participants (23.3%) fulfilled the EWGSOP2 criteria of sarcopenia, and 9 (12.3%) criteria for severe sarcopenia. Fourteen (19.2%) participants fulfilled the SARC-F criteria for clinical suspicion of sarcopenia. The Cronbach’s alpha coefficient for internal was 0.84. With EWGSOP2 sarcopenia as a gold standard, the sensitivity of SARC-F was 35.3% (95% CI 14.2–61.7, p = 0.33), specificity was 85.7% (95% CI 73.8–93.6, p p = 0.79) and 81.4% (p p p = 0.33). Overall the predictive power of SARC-F was low (c-statistic 0.64). Discussion SARC-F is currently recommended for sarcopenia case finding in general population of older adults. However, its sensitivity is low, despite high specificity. Conclusions At present SARC-F is better suited to rule out sarcopenia then to case-finding. Further refinement of screening for sarcopenia with the use of SARC-F seems needed.
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- 2021
6. Reduction of 24-h blood pressure variability in extreme obese patients 10 days and 6 months after bariatric surgery depending on pre-existing hypertension
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Barbara Gryglewska, Tomasz Grodzicki, Andrea Faini, Grzegorz Bilo, A. Dzieza-Grudnik, Gianfranco Parati, Andrzej Budzyński, Jerzy Gąsowski, Piotr Major, B. Zarzycki, Anna Głuszewska, Głuszewska, A, Gryglewska, B, Gąsowski, J, Bilo, G, Zarzycki, B, Dzieża-Grudnik, A, Major, P, Budzyński, A, Faini, A, Parati, G, and Grodzicki, T
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Bariatric surgery ,medicine.medical_specialty ,Ambulatory blood pressure ,business.industry ,medicine.medical_treatment ,Diastole ,030204 cardiovascular system & hematology ,medicine.disease ,Obesity ,Surgery ,Residual risk ,First line treatment ,03 medical and health sciences ,0302 clinical medicine ,Blood pressure ,Hypertension ,Internal Medicine ,medicine ,In patient ,030212 general & internal medicine ,business ,Reduction (orthopedic surgery) - Abstract
Bariatric surgery is considered as a first line treatment in extreme obese patients to achieve a reduction in health risks. However, after surgical procedure obese patients with normal blood pressure (BP) levels still present residual risk, which may be partly related to lack of correction of BP profile and variability. Aim: To evaluate short (10 days) and mid-term (6 months) changes of mean values, profile and variability of BP after bariatric surgery in extremely obese patients with and without hypertension. Materials & methods: A follow-up of cross-sectional study was conducted in 90 obese patients (aged 41.7 ± 11.3, BMI = 46.7 ± 5.7 kg/m2), who met the eligibility criteria and underwent bariatric surgery. Each patient underwent 24-h ambulatory BP monitoring with profile and variability estimation before, 10 days and 6 months after the intervention. Results: Sixty-seven (74.4%) patients had hypertension. Significant decrease from baseline in mean values of systolic and diastolic BP in 10 days (p < .005) and 6 months (p < .005) follow-up were observed only in patients with hypertension. Moreover, only hypertensive subjects revealed significant reduction (p < 0,05) from baseline in 24-h systolic and diastolic BP weighted standard deviation and average real variability after surgical procedure. No changes were found in dipping status. Conclusions: Bariatric surgery not only decreased BP levels, but also contributed to reduction in BP variability in early period after intervention mainly in patients with pre-existing hypertension
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- 2019
7. <scp>P</scp>ost‐occlusive reactive hyperemic response of skin microcirculation among extremely obese patients in the short and long term after bariatric surgery
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Jerzy Gąsowski, Piotr Major, Małgorzata Fedyk-Łukasik, Anna Głuszewska, Bartosz Zarzycki, Tomasz Grodzicki, Andrzej Budzyński, Barbara Gryglewska, and Anna Dzieża-Grudnik
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Adult ,Male ,medicine.medical_specialty ,Physiology ,Bariatric Surgery ,Adipokine ,Hyperemia ,030204 cardiovascular system & hematology ,Microcirculation ,Anthropometric parameters ,03 medical and health sciences ,0302 clinical medicine ,Physiology (medical) ,Occlusion ,Laser-Doppler Flowmetry ,medicine ,Humans ,Hyperemic response ,In patient ,Prospective Studies ,Molecular Biology ,Skin ,Skin blood flow ,business.industry ,Middle Aged ,Obesity, Morbid ,Surgery ,Laser doppler fluxmetry ,Female ,Cardiology and Cardiovascular Medicine ,business ,030217 neurology & neurosurgery - Abstract
OBJECTIVE To assess changes of post-occlusive reactive hyperemic response in skin microcirculation among extremely obese patients 10 days and 6 months after bariatric surgery for patients with and without hypertension. METHODS Skin blood flow was measured using PeriFlux laser Doppler fluxmetry. Data were analyzed in the entire group and two subgroups: with and without hypertension. RESULTS Data from 88 patients (mean age 42.1 ± 11.2 years, 40.5% men) were analyzed. Six months after bariatric surgery, the time to reach peak flows had been shortened (2.4 ± 1.7 vs 2.1 ± 1.0 seconds, P
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- 2020
8. Post‐occlusive reactive hyperemic response of skin microcirculation among extremely obese patients in the short and long term after bariatric surgery
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Gryglewska, Barbara, primary, Głuszewska, Anna, additional, Zarzycki, Bartosz, additional, Dzieża‐ Grudnik, Anna, additional, Fedyk‐Łukasik, Małgorzata, additional, Major, Piotr, additional, Budzyński, Andrzej, additional, Gąsowski, Jerzy, additional, and Grodzicki, Tomasz, additional
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- 2020
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9. Impact of bariatric surgery on non-alcoholic fatty liver disease
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Michał Pędziwiatr, Mateusz Rubinkiewicz, Piotr Major, Magdalena Pisarska, Piotr Budzyński, Piotr Małczak, Anna Głuszewska, Maciej Stanek, and Andrzej Budzyński
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Adult ,Male ,chirurgia bariatryczna ,medicine.medical_specialty ,bariatric surgery ,Bariatric Surgery ,Type 2 diabetes ,Disease ,Morbid obesity ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,Non-alcoholic Fatty Liver Disease ,Weight loss ,Weight Loss ,medicine ,Humans ,030212 general & internal medicine ,otyłość olbrzymia ,business.industry ,Fatty liver ,non-alcoholic fatty liver disease ,Alanine Transaminase ,General Medicine ,Middle Aged ,medicine.disease ,Obesity ,niealkoholowa stłuszczeniowa choroba wątroby ,Obesity, Morbid ,morbid obesity ,Surgery ,Treatment Outcome ,Female ,030211 gastroenterology & hepatology ,Poland ,Liver function ,medicine.symptom ,business ,Body mass index ,Follow-Up Studies - Abstract
Wstęp: prawie 300 milionów ludzi na świecie BMI przekracza 30 (kg/m2). Otyłość jest przyczyną wielu poważnych schorzeń, takich jak cukrzyca typu 2, nadciśnienie tętnicze czy niealkoholowe stłuszczenie wątroby. Chirurgia bariatryczna jest jedyną efektywną metodą uzyskania redukcji masy ciała u pacjentów z otyłością olbrzymią. Cele: Celem tej pracy jest ocena wpływu chirurgii bariatrycznej na niealkoholowe stłuszczenie wątroby u pacjentów operowanych z powodu otyłości olbrzymiej. Materiał i metodologia: Włączyliśmy 20 pacjentów zakwalifikowanych do zabiegu bariatrycznego z BMI >40 kg/m2 lub BMI >35kg/m2 z współwystępującymi chorobami towarzyszącymi. Średnia masa ciała badanej grupy wynosiła 143,85 kg, ze średnim BMI 49,16 kg/m2. Przed zabiegiem dokonano oceny stopnia niealkoholowego stłuszczenia wątroby przy użyciu skali Sherifa Saadeha podczas badania ultrasonograficznego. Dokonaliśmy także oceny stężeń enzymów wątrobowych. Obserwację i wizyty kontrolne kontynuowano do 12 miesięcy po zabiegu. Wyniki: Dwanaście miesięcy po operacji średnia masa ciała badanej grupy wynosiła 102,34 kg. WL wyniosło średnio 33,0%, EWL 58,8%, a EBMIL 61,37%. U wszystkich pacjentów zaobserwowano remisję stłuszczenia wątroby. Uszkodzenie wątroby, ocenione przy użyciu ultrasonografii, zmniejszyło się ze średnio 1,85 pkt w skali Sherifa Saadeha przed zabiegiem do 0,15 pkt po 12 miesiącach (p=0,00). Poziomy enzymów wątrobowych zmalały z 64,5 (U/l) do 27,95 (U/l) dla ALT (p=0,00) oraz z 54,4 (U/l) do 27,2 (U/l) dla AST. Wnioski: rocedury bariatryczne nie tylko pozwalają na znaczącą oraz trwała utratę masy ciała, ale także przyczyniają się do zmniejszenia stłuszczenia wątroby oraz poprawy jej funkcjonowania. Introduction; p to 300 million people have the body mass index (BMI) greater than 30 kg/m2. Obesity is the cause of many serious diseases, such as type 2 diabetes, hypertension, and non-alcoholic fatty liver disease (NAFLD). Bariatric surgery is the only effective method of achieving weight loss in patients with morbid obesity. Objectives: The aim of the study was to assess the impact of bariatric surgery on non-alcoholic fatty liver disease in patients operated on due to morbid obesity. Material and Methods: We included 20 patients who were qualified for bariatric procedures based on BMI > 40 kg/ m2 or BMI > 35kg/m2 with the presence of comorbidities. The average body weight in the group was 143.85kg, with an average BMI of 49.16kg/m2. Before the procedure, we evaluated the severity of non-alcoholic fatty liver disease in each patient using the Sheriff-Saadeh ultrasound scale. We also evaluated the levels of liver enzymes. Follow-up evaluation was performed twelve months after surgery. Results: Twelve months after surgery, the average weight was 102.34 kg. The mean %WL was 33.01%, %EWL was 58.8%, and %EBMIL was 61.37%. All patients showed remission of fatty liver disease. Liver damage, evaluated with ultrasound imaging, decreased from an average of 1.85 on the Sheriff-Saadeh scale, before surgery, to 0.15 twelve months after surgery (p < 0.001). As regards liver enzymes, the level of alanine aminotransferase decreased from 64.5 (U/l) to 27.95 (U/l) (p < 0.001), and the level of aspartate aminotransferase decreased from 54.4 (U/l) to 27.2 (U/l). Conclusions: Bariatric procedures not only lead to a significant and lasting weight loss, but they also contribute to the reduction of fatty liver disease and improve liver function.
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- 2017
10. Impact of cuff positioning on blood pressure measurement accuracy: may a specially designed cuff make a difference?
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Juan Eugenio Ochoa, Andrea Faini, Grzegorz Bilo, Oscar Sala, Lan Gao, Dario Pellegrini, Anna Głuszewska, Laura Lonati, Gianfranco Parati, Carlotta Perego, Bilo, G, Sala, O, Perego, C, Faini, A, Gao, L, Gluszewska, A, Ochoa, J, Pellegrini, D, Lonati, L, and Parati, G
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Adult ,Male ,Systematic error ,Blood pressure determination ,medicine.medical_specialty ,Physiology ,sphygmomanometers ,030204 cardiovascular system & hematology ,diagnostic errors ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,medicine.artery ,Sphygmomanometer ,Internal Medicine ,medicine ,Humans ,Obesity ,030212 general & internal medicine ,Brachial artery ,Aged ,business.industry ,Middle Aged ,musculoskeletal system ,Circumference ,Diagnostic error ,Surgery ,Blood pressure ,Cuff ,Female ,Original Article ,Home blood pressure monitoring ,Cardiology and Cardiovascular Medicine ,Nuclear medicine ,business - Abstract
During blood pressure (BP) measurement, the recommended positioning of the cuff bladder center is directly above the brachial artery. We investigated the relevance of incorrect cuff positioning during (1) auscultatory measurement with an appropriate or improperly small cuff and (2) oscillometric measurement with a wide-range cuff designed to guarantee accurate measurements regardless of position. In subjects with wide BP and arm circumference ranges, (1) auscultatory BP was repeatedly measured with a properly positioned cuff (reference) and, simultaneously, with an identical cuff placed on the other arm in either a correct or an incorrect position (test). The measurements were performed with a properly sized (N=57) or an improperly small cuff (N=33). (2) Auscultatory measurements obtained with a properly positioned and sized cuff were compared with oscillometric measurements obtained with a specially designed wide-range cuff (Omron IntelliWrap) placed on the contralateral arm either in a correct or an incorrect position. Auscultatory BP measures were unaffected by incorrect positioning of a properly sized cuff, whereas with undercuffing, BP was overestimated with the cuff displaced by 90° laterally (systolic/diastolic BP differences: 4.9±4.6/4.0±4.6 mm Hg, P
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- 2017
11. Insulin Resistance and Renal Sodium Handling Influence Arterial Stiffness in Hypertensive Patients with Prevailing Sodium Intake
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Barbara Gryglewska, Henryk Bartoń, Aleksander Kwater, Jerzy Gąsowski, Maria Fołta, Anna Głuszewska, Marcin Cwynar, Tomasz Grodzicki, and Jarosław Królczyk
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Male ,medicine.medical_specialty ,medicine.medical_treatment ,Sodium ,Population ,chemistry.chemical_element ,Natriuresis ,030204 cardiovascular system & hematology ,Ventricular Function, Left ,Excretion ,03 medical and health sciences ,Ventricular Dysfunction, Left ,0302 clinical medicine ,Insulin resistance ,Vascular Stiffness ,Internal medicine ,Internal Medicine ,medicine ,Humans ,Arterial Pressure ,030212 general & internal medicine ,education ,Aged ,education.field_of_study ,Renal sodium reabsorption ,Ventricular Remodeling ,Reabsorption ,business.industry ,Insulin ,Sodium, Dietary ,Middle Aged ,medicine.disease ,Renal Reabsorption ,Renal Elimination ,Endocrinology ,Kidney Tubules ,chemistry ,Hypertension ,Arterial stiffness ,Female ,Insulin Resistance ,business - Abstract
BACKGROUND Insulin resistance and renal tubular sodium handling influence arterial structure and function and play an essential role in salt-sensitive forms of hypertension. METHODS In a population with prevailing sodium consumption, we assessed the relationship between cardiovascular phenotypes (peripheral and central blood pressures, elastic properties of large arteries, the left ventricular structure) and sodium handling parameters (daily urinary sodium excretion, fractional urinary lithium excretion in proximal—FELi and distal tubules), as a function of insulin sensitivity—measured by homeostasis model assessment–insulin resistance (HOMA-IR), leptin-to-adiponectin (L/A) ratio, and homeostasis model assessment–adiponectin (HOMA-AD). RESULTS In patients with FELi below the median value (corresponding to the group with increased proximal sodium reabsorption) and higher insulin resistance as measured by HOMA-IR, pulse wave augmentation indexes were significantly higher—AIxP (99.4% vs. 86.2%; P = 0.007), AIxC1 (159.4% vs. 144.2%; P = 0.04), and AIxC2 (36.1% vs. 28.3%; P = 0.02), than in patients with lower insulin resistance. The same trend was observed in relation to L/A ratio—AIxP (98.7% vs. 87.1%; P = 0.005), AIxC1 (158.6% vs. 144.5%; P = 0.02), and AIxC2 (35.6% vs. 28.5%; P = 0.01) and HOMA-AD—AIxP (99.7% vs. 83.8%; P = 0.001), AIxC1 (160.5% vs. 140.3%; P = 0.007), and AIxC2 (36.6% vs. 26.3%; P = 0.003). Such relationships were not observed in patients with FELi above the median value. CONCLUSIONS In the hypertensive population with prevailing sodium intake, insulin resistance and increased sodium reabsorption in proximal tubules may affect arterial wall function.
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- 2019
12. Author's Reply : issues regarding ambulatory blood pressure measurement in severely obese population: The guilty upper-arm' Item cover sheet has been updated accordingly
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Jerzy Gąsowski, Anna Głuszewska, and Barbara Gryglewska
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medicine.medical_specialty ,education.field_of_study ,business.industry ,Population ,Bariatric Surgery ,Blood Pressure ,Blood Pressure Determination ,Blood Pressure Monitoring, Ambulatory ,Ambulatory blood pressure measurement ,Hypertension ,Internal Medicine ,Physical therapy ,Arm ,Medicine ,Humans ,Cover (algebra) ,Obesity ,business ,education - Published
- 2019
13. Arterial structure and function and its short- and long-term changes after bariatric surgery
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Głuszewska, Anna, Gryglewska, Barbara, Rewiuk, Krzysztof, Zarzycki, Bartosz, Dzieża-Grudnik, Anna, Kwater, Aleksander, Major, Piotr, Budzyński, Andrzej, Gąsowski, Jerzy, and Grodzicki, Tomasz
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- 2019
14. P8.10 Effects of Bariatric Surgery on Endothelial Function in Extremely Obese Patients
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Dzieża-Grudnik, Anna, Głuszewska, Anna, Rewiuk, Krzysztof, Kwater, Aleksander, Zarzycki, Bartosz, Fedyk-Łukasik, Małgorzata, Gryglewska, Barbara, and Grodzicki, Tomasz
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- 2015
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15. Author's Reply: Issues regarding ambulatory blood pressure measurement in severely obese population: The guilty upper-arm' Item cover sheet has been updated accordingly
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Głuszewska, Anna, primary, Gryglewska, Barbara, additional, and Gąsowski, Jerzy, additional
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- 2019
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16. Insulin Resistance and Renal Sodium Handling Influence Arterial Stiffness in Hypertensive Patients with Prevailing Sodium Intake
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Cwynar, Marcin, primary, Gąsowski, Jerzy, additional, Gryglewska, Barbara, additional, Głuszewska, Anna, additional, Kwater, Aleksander, additional, Królczyk, Jarosław, additional, Fołta, Maria, additional, Bartoń, Henryk, additional, and Grodzicki, Tomasz, additional
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- 2019
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17. Identification of Seniors at Risk scale as a simple tool of elderly patients' assessment in an acute hospital department
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Anna, Głuszewska, Barbara, Gryglewska, Stanisław, Górski, Anna, Kańtoch, and Tomasz, Grodzicki
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Aged, 80 and over ,Male ,Predictive Value of Tests ,Surveys and Questionnaires ,Outcome Assessment, Health Care ,Humans ,Accidental Falls ,Female ,Length of Stay ,Geriatric Assessment ,Risk Assessment ,Aged - Abstract
e aim of the study was to evaluate the usefulness of Identification of Seniors at Risk (ISAR) scale among elderly patients admitted to the department of internal medicine.The ISAR score was performed among patients aged59 years a er admission to the hospital ward. Data from medical history about diseases, taken medicines, falls, length of hospital stay and mortality were compared in patients with ISAR score of 0-1 and over 1 and in subjects with and without history of falls. Regression analysis was used to detect predictors of the length of hospital stay or death.The sample consisted of 102 subjects aged 80.9 ± 7.9 years, 45.5% of men, 34.6% had history of falls. The number of diseases was 11.3 ± 3.9 and number of medicines - 8.9 ± 3.7. The score of ISAR ≥2 was found in 90.2% of patients, length of hospital stay was 10.3 ± 8.4 days, mortality rate was 9.9%. Patients with ISAR score2 were younger, showed a smaller number of diseases, used less drugs and had less frequency of falls than those with score ≥2. Patients with history of falls had higher mean ISAR score, higher number of diseases and medicines than the others. The increased number of diseases and higher ISAR score significantly influenced the length of hospital stay. None of the analyzed factors had any impact on mortality.The score of ISAR scale together with number of diseases have a positive impact on the length of hospital stay.
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- 2017
18. The relation between ACE D/I and CYP11B2 C-344T polymorphisms and parameters of arterial stiffness in the context of renal sodium handling
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Cwynar, Marcin, Gąsowski, Jerzy, Gryglewska, Barbara, Głuszewska, Anna, Bartoń, Henryk, Słowik, Agnieszka, and Grodzicki, Tomasz
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Male ,medicine.medical_specialty ,Sodium ,Urology ,chemistry.chemical_element ,Blood Pressure ,Peptidyl-Dipeptidase A ,Kidney ,Excretion ,Vascular Stiffness ,Internal medicine ,Internal Medicine ,medicine ,Cytochrome P-450 CYP11B2 ,Humans ,Aged ,Polymorphism, Genetic ,Renal sodium reabsorption ,Urinary sodium ,business.industry ,General Medicine ,Middle Aged ,medicine.disease ,Peripheral ,Endocrinology ,medicine.anatomical_structure ,Blood pressure ,chemistry ,Hypertension ,Arterial stiffness ,Female ,Cardiology and Cardiovascular Medicine ,business - Abstract
Background. Sodium overload is related to the development of primary hypertension and its complications. Methods. In 131 (65 female) treated hypertensives (average blood pressure 144/82 mmHg and duration of hypertension 11.7 years), we measured peripheral and central arterial pressures, peripheral (AIxP) and central (AIxC1, AIxC2) augmentation indices, pulse-wave velocity (PWV) and daily urinary sodium excretion, and conducted genetic studies of ACE D/I and CYP11B2 C-344T polymorphisms. Proximal (FELi) and distal (FDRNa) sodium reabsorption measurements were performed using endogenous lithium clearance. Results. We found statistically significant interactions between FELi and ACE D/I polymorphism with respect to AIxC2 (PINT = 0.05) and between FELi and CYP11B2 C-344T polymorphism with respect to AIxC1 (PINT = 0.01), AIxC2 (PINT = 0.04) and AIxP (PINT = 0.01). In the group of ACE I allele carriers compared with DD homozygotes, the AIxC1 (154.1 vs 140.6%; p = 0.02), AIxC2 (33.3 vs 26.9%; p = 0.02) and AIxP (94.6 vs 85.2%; p = 0.01) were higher in the subgroup with FELi below the median value (FELi1), but not in the subgroup with FELi above the median value (FELi2). In the group of CYP11B2 TT homozygotes compared with C allele carriers, we observed higher values of AIxC1 (158.5 vs 146.4%; p = 0.03), AIxC2 (36.0 vs 29.4%; p = 0.01) and AIxP (99.0 vs 88.7%; p = 0.005) in the FELi1 but not the FELi2 subgroup. Conclusions. In the population with assumed high dietary sodium intake and long-standing history of hypertension, the relation between proximal sodium reabsorption and the development of arterial stiffness depends on the genetic context of the selected genetic polymorphisms of the renin—angiotensin—aldosterone system, independent of blood pressure.
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- 2015
19. Identification of Seniors at Risk scale as a simple tool of elderly patients' assessment in an acute hospital department
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Głuszewska, Anna, Gryglewska, Barbara, Górski, Stanisław, Kańtoch, Anna, and Grodzicki, Tomasz
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ISAR ,length of hospital stay ,elderly ,hospitalization - Published
- 2017
20. Blood pressure, arterial stiffness and endogenous lithium clearance in relation to AGTR1 and AGTR2 gene polymorphisms
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Marcin Cwynar, Jerzy Gąsowski, Anna Głuszewska, Jarosław Królczyk, Henryk Bartoń, Agnieszka Słowik, and Tomasz Grodzicki
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Medicine (General) ,R5-920 - Abstract
Introduction: Although recently a matter of epidemiologic controversy, sodium overload and its interaction with genetic factors predispose to hypertension and related target organ complications. Methods: In 131 (66 male) treated hypertensives, we measured peripheral and central arterial pressures and pulse wave augmentation indexes (AIx P , AIx C1 , AIx C2 ), pulse wave velocity (PWV), daily urinary sodium excretion and did genetic studies of AGTR1 A1166C and AGTR2 G1675A polymorphisms. Proximal (FE Li ) and distal (FDR Na ) sodium reabsorption measurements were performed using endogenous lithium clearance. Results: In men, we found interaction between FDR Na and AGTR2 G1675A polymorphism with respect to AIx C1 ( p INT =0.01), AIx C2 ( p INT =0.05) and AIx P ( p INT =0.006). Arterial stiffness increased with higher sodium reabsorption in the distal tubule, in the presence of AGTR2 G allele with the opposite tendency in A allele carriers. In the subgroup with FDR Na below median, as compared to those with FDR Na above median, the AIx C1 (139.6±3.8 vs 159.1±5.7%; p =0.009), AIx C2 (26.3±1.8 vs 33.3±1.7%; p =0.016) and AIx P (83.4±2.5 vs 96.5±2.6%; p
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- 2016
21. Blood pressure, arterial stiffness and endogenous lithium clearance in relation to AGTR1 A1166C and AGTR2 G1675A gene polymorphisms
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Cwynar, Marcin, Gąsowski, Jerzy, Głuszewska, Anna, Królczyk, Jarosław, Bartoń, Henryk, Słowik, Agnieszka, and Grodzicki, Tomasz
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Male ,0301 basic medicine ,medicine.medical_specialty ,hypertension ,Lithium (medication) ,Sodium ,AGTR2 G1675A ,chemistry.chemical_element ,Blood Pressure ,Lithium ,030204 cardiovascular system & hematology ,Polymorphism, Single Nucleotide ,Receptor, Angiotensin, Type 2 ,Receptor, Angiotensin, Type 1 ,Excretion ,03 medical and health sciences ,Vascular Stiffness ,0302 clinical medicine ,Endocrinology ,Internal medicine ,Internal Medicine ,medicine ,Humans ,Allele ,Pulse wave velocity ,Alleles ,distal sodium reabsorption ,Renal sodium reabsorption ,business.industry ,Middle Aged ,medicine.disease ,arterial stiffness ,030104 developmental biology ,Blood pressure ,chemistry ,Hypertension ,Arterial stiffness ,Female ,Original Article ,business ,medicine.drug - Abstract
Introduction: Although recently a matter of epidemiologic controversy, sodium overload and its interaction with genetic factors predispose to hypertension and related target organ complications. Methods: In 131 (66 male) treated hypertensives, we measured peripheral and central arterial pressures and pulse wave augmentation indexes (AIxP, AIxC1, AIxC2), pulse wave velocity (PWV), daily urinary sodium excretion and did genetic studies of AGTR1 A1166C and AGTR2 G1675A polymorphisms. Proximal (FELi) and distal (FDRNa) sodium reabsorption measurements were performed using endogenous lithium clearance. Results: In men, we found interaction between FDRNa and AGTR2 G1675A polymorphism with respect to AIxC1 ( pINT=0.01), AIxC2 ( pINT=0.05) and AIxP ( pINT=0.006). Arterial stiffness increased with higher sodium reabsorption in the distal tubule, in the presence of AGTR2 G allele with the opposite tendency in A allele carriers. In the subgroup with FDRNa below median, as compared to those with FDRNa above median, the AIxC1 (139.6±3.8 vs 159.1±5.7%; p=0.009), AIxC2 (26.3±1.8 vs 33.3±1.7%; p=0.016) and AIxP (83.4±2.5 vs 96.5±2.6%; pConclusions: The relation between sodium reabsorption in the distal tubule and the development of arterial stiffness depends on the AGTR2 G1675A polymorphism in blood pressure independent fashion.
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- 2016
22. Impact of bariatric surgery on non-alcoholic fatty liver disease
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Major, Piotr, primary, Pędziwiatr, Michał, additional, Rubinkiewicz, Mateusz, additional, Stanek, Maciej, additional, Głuszewska, Anna, additional, Pisarska, Magdalena, additional, Małczak, Piotr, additional, Budzyński, Andrzej, additional, and Budzyński, Piotr, additional
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- 2017
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23. Effects of bariatric surgery on cardiovascular risk factors among morbidly obese patients
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Major, Piotr, primary, Kowalczuk, Aleksandra, additional, Wysocki, Michał, additional, Osadnik, Sonia, additional, Pędziwiatr, Michał, additional, Głuszewska, Anna, additional, Pisarska, Magdalena, additional, Małczak, Piotr, additional, Lasek, Anna, additional, Kisielewski, Michał, additional, and Budzyński, Andrzej, additional
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- 2017
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24. Impact of cuff positioning on blood pressure measurement accuracy: may a specially designed cuff make a difference?
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Bilo, Grzegorz, primary, Sala, Oscar, additional, Perego, Carlotta, additional, Faini, Andrea, additional, Gao, Lan, additional, Głuszewska, Anna, additional, Ochoa, Juan Eugenio, additional, Pellegrini, Dario, additional, Lonati, Laura Maria, additional, and Parati, Gianfranco, additional
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- 2017
- Full Text
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25. Assessment of elderly patients admitted to an internal hospital department using VES-13 scale
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Gryglewska, Barbara, Głuszewska, Anna, Górski, Stanisław, and Grodzicki, Tomasz
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- 2014
26. Blood pressure, arterial stiffness and endogenous lithium clearance in relation to AGTR1 A1166C and AGTR2 G1675A gene polymorphisms
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Cwynar, Marcin, primary, Gąsowski, Jerzy, additional, Głuszewska, Anna, additional, Królczyk, Jarosław, additional, Bartoń, Henryk, additional, Słowik, Agnieszka, additional, and Grodzicki, Tomasz, additional
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- 2016
- Full Text
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27. Identification of Seniors at Risk scale as a hazard of longer stay in hospital
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Gryglewska, B., primary, Głuszewska, A., additional, Szczerbińska, K., additional, Skalska, A., additional, and Grodzicki, T., additional
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- 2013
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28. Identification of Seniors at Risk scale as a hazard of longer stay in hospital
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Barbara Gryglewska, Katarzyna Szczerbińska, Anna Głuszewska, Anna Skalska, and Tomasz Grodzicki
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Identification (information) ,medicine.medical_specialty ,business.industry ,Scale (social sciences) ,Emergency medicine ,medicine ,Geriatrics and Gerontology ,business ,Gerontology ,Hazard - Published
- 2013
29. Effects of bariatric surgery on endothelial function in extremely obese patients
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Dzieża-Grudnik, Anna, Głuszewska, Anna, Rewiuk, Krzysztof, Kwater, Aleksander, Zarzycki, Bartosz, Fedyk-Łukasik, Małgorzata, Gryglewska, Barbara, and Grodzicki, Tomasz
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- 2015
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30. Blood pressure and arterial stiffness in patients with high sodium intake in relation to sodium handling and left ventricular diastolic dysfunction status
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Cwynar, Marcin, Gąsowski, Jerzy, Stompór, Tomasz, Bartoń, Henryk, Wizner, Barbara, Dubiel, M., Głuszewska, A., Królczyk, Jarosław, Franczuk, Paweł, and Grodzicki, Tomasz
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Male ,medicine.medical_specialty ,Heart Ventricles ,Sodium ,High sodium ,chemistry.chemical_element ,Blood Pressure ,Pulse Wave Analysis ,Ventricular Function, Left ,Ventricular Dysfunction, Left ,Vascular Stiffness ,Internal medicine ,Internal Medicine ,medicine ,Humans ,In patient ,Retrospective Studies ,business.industry ,Sodium, Dietary ,Middle Aged ,medicine.disease ,Echocardiography, Doppler ,Blood pressure ,chemistry ,Hypertension ,Cardiology ,Arterial stiffness ,Female ,Left ventricular diastolic dysfunction ,business ,Follow-Up Studies - Abstract
In a population with high sodium consumption, we assessed relation between brachial and central blood pressures, elastic properties of large arteries, echocardiographic left ventricular diastolic function and sodium reabsorption as fractional urinary lithium excretion in proximal (FELi) and fractional sodium reabsorption in distal tubules assessed using the endogenous lithium clearance. Mean±s.d. age of 131 treated hypertensive patients (66 men and 65 women) was 61.9±7.5 years. We found significant interaction between left ventricular diastolic function and FELi with respect to the values of brachial blood pressure: systolic (SBP), diastolic (DBP) and mean blood pressure (MBP) (all PINT0.03). In patients with FELi below the median value and impaired left ventricular diastolic function, the values of SBP (149.3 vs 132.5 mm Hg; P=0.005), DBP (85.1 vs 76.1 mm Hg; P=0.001), MBP (106.5 vs 94.9 mm Hg; P=0.001), central SBP (SBPC) (137.4 vs 122.0 mm Hg; P=0.01), central DBP (DBPC) (84.8 vs 76.0 mm Hg; P=0.003), central MBP (MBPC) (106.9 vs 95.9 mm Hg; P=0.007), aortic pulse wave augmentation (18.0 vs 13.5 mm Hg; P=0.03), pulse wave velocity (14.6 vs 12.5 m s(-1); P=0.02) and central aortic pulse wave augmentation index (155.7% vs 140.9%; P=0.01) were significantly higher than in patients with normal left ventricular diastolic function. Such relationships were not observed in the entire group and patients with FELi above the median value. In the hypertensive population with high sodium intake, increased sodium reabsorption in proximal tubules may affect blood pressure parameters and arterial wall damage, thus contributing to the development of left ventricular diastolic function impairment.
31. Impact of bariatric surgery on non-alcoholic fatty liver disease.
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Major P, Pędziwiatr M, Rubinkiewicz M, Stanek M, Głuszewska A, Pisarska M, Małczak P, Budzyński A, and Budzyński P
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- Adult, Alanine Transaminase blood, Female, Follow-Up Studies, Humans, Male, Middle Aged, Non-alcoholic Fatty Liver Disease etiology, Obesity, Morbid complications, Obesity, Morbid enzymology, Poland, Treatment Outcome, Weight Loss, Young Adult, Bariatric Surgery, Non-alcoholic Fatty Liver Disease enzymology, Non-alcoholic Fatty Liver Disease surgery, Obesity, Morbid surgery
- Abstract
Introduction; p to 300 million people have the body mass index (BMI) greater than 30 kg/m2. Obesity is the cause of many serious diseases, such as type 2 diabetes, hypertension, and non-alcoholic fatty liver disease (NAFLD). Bariatric surgery is the only effective method of achieving weight loss in patients with morbid obesity., Objectives: The aim of the study was to assess the impact of bariatric surgery on non-alcoholic fatty liver disease in patients operated on due to morbid obesity., Material and Methods: We included 20 patients who were qualified for bariatric procedures based on BMI > 40 kg/ m2 or BMI > 35kg/m2 with the presence of comorbidities. The average body weight in the group was 143.85kg, with an average BMI of 49.16kg/m2. Before the procedure, we evaluated the severity of non-alcoholic fatty liver disease in each patient using the Sheriff-Saadeh ultrasound scale. We also evaluated the levels of liver enzymes. Follow-up evaluation was performed twelve months after surgery., Results: Twelve months after surgery, the average weight was 102.34 kg. The mean %WL was 33.01%, %EWL was 58.8%, and %EBMIL was 61.37%. All patients showed remission of fatty liver disease. Liver damage, evaluated with ultrasound imaging, decreased from an average of 1.85 on the Sheriff-Saadeh scale, before surgery, to 0.15 twelve months after surgery (p < 0.001). As regards liver enzymes, the level of alanine aminotransferase decreased from 64.5 (U/l) to 27.95 (U/l) (p < 0.001), and the level of aspartate aminotransferase decreased from 54.4 (U/l) to 27.2 (U/l)., Conclusions: Bariatric procedures not only lead to a significant and lasting weight loss, but they also contribute to the reduction of fatty liver disease and improve liver function.
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- 2017
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32. Effects of bariatric surgery on cardiovascular risk factors among morbidly obese patients.
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Major P, Kowalczuk A, Wysocki M, Osadnik S, Pędziwiatr M, Głuszewska A, Pisarska M, Małczak P, Lasek A, Kisielewski M, and Budzyński A
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- Adult, Female, Follow-Up Studies, Humans, Hypertension prevention & control, Male, Middle Aged, Prospective Studies, Risk Factors, Bariatric Surgery methods, Cardiovascular Diseases prevention & control, Obesity, Morbid surgery
- Abstract
Aim of the Study: The aim of this study was to evaluate the influence of laparoscopic sleeve gastrectomy and laparoscopic Roux-en-Y gastric by-pass on risk factors of cardiovascular diseases., Material and Methods: We analyzed prospectively collected data of patients operated for morbid obesity who were qualified for laparoscopic sleeve gastrectomy (LSG) or laparoscopic Roux-en-Y gastric by-pass (LRYGB). Risk factors for wyłączecardiovascular diseases were assessed with the SCORE scale and both full and hard Framingham cardiovascular risk scores (FCRs). The data were collected on admission and one year after the procedures. We enrolled 264 patients (119 females, 116 males, 40.2±9.9 years old), of whom 117 underwent LRYGB and 118 LSG, respectively., Results: Preoperatively, 12% of patients were in the high-risk category of the SCORE scale, 65% were in the moderate risk category, and 24% were in the low-risk category. The median score of the SCORE scale was 1 (1-2). Lipid-based full FCR was 34.5% (24%-68%) and the hard FCR was 17.5% (10%-52%), while the respective BMI-based FCRs were 59% (31%-84%) and 37% (15%-67%). One year after the procedures, the mean %EBMIL (62.88%±20.02%) and %EWL (53.18%±15.87) were comparable between both procedures. Hypertension treatment was not necessary in 33 patients after LSG and in 55 after LRYGB. Diabetes mellitus remitted in 9 and 29 patients, respectively. Both procedures significantly reduced high and moderate risk prevalence in the SCORE scale in favor of the low risk category. Surgical interventions resulted in significant reductions of FCRs 1 year after surgery ( p<0.001)., Conclusions: Both LSG and LRYGB lead to a significant and comparable body mass reduction. Both procedures significantly decrease of the risk of cardiovascular diseases, based on SCORE and Framingham scales.
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- 2017
- Full Text
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33. Identification of Seniors at Risk scale as a simple tool of elderly patients' assessment in an acute hospital department.
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Głuszewska A, Gryglewska B, Górski S, Kańtoch A, and Grodzicki T
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- Accidental Falls statistics & numerical data, Aged, Aged, 80 and over, Female, Humans, Length of Stay statistics & numerical data, Male, Outcome Assessment, Health Care, Predictive Value of Tests, Geriatric Assessment methods, Risk Assessment statistics & numerical data, Surveys and Questionnaires statistics & numerical data
- Abstract
Introduction: e aim of the study was to evaluate the usefulness of Identification of Seniors at Risk (ISAR) scale among elderly patients admitted to the department of internal medicine., Material and Methods: The ISAR score was performed among patients aged >59 years a er admission to the hospital ward. Data from medical history about diseases, taken medicines, falls, length of hospital stay and mortality were compared in patients with ISAR score of 0-1 and over 1 and in subjects with and without history of falls. Regression analysis was used to detect predictors of the length of hospital stay or death., Results: The sample consisted of 102 subjects aged 80.9 ± 7.9 years, 45.5% of men, 34.6% had history of falls. The number of diseases was 11.3 ± 3.9 and number of medicines - 8.9 ± 3.7. The score of ISAR ≥2 was found in 90.2% of patients, length of hospital stay was 10.3 ± 8.4 days, mortality rate was 9.9%. Patients with ISAR score <2 were younger, showed a smaller number of diseases, used less drugs and had less frequency of falls than those with score ≥2. Patients with history of falls had higher mean ISAR score, higher number of diseases and medicines than the others. The increased number of diseases and higher ISAR score significantly influenced the length of hospital stay. None of the analyzed factors had any impact on mortality., Conclusion: The score of ISAR scale together with number of diseases have a positive impact on the length of hospital stay.
- Published
- 2017
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