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Abstract Background Knobloch syndrome (KNO, OMIM # 267,750) is a rare ciliopathy group sydrome characterized by a collagen synthesis disorder. It represents an uncommon cause of pediatric retinal detachment. This report presents two cases with different COL18A1 gene mutations, complicated by retinal detachment. Case presentation Both cases exhibited high myopia and various degrees of occipital skull defect. The first case, a female, had bilateral congenital retinal detachment, posterior embryotoxon, and strabismus. The second case, a male, had unilateral congenital retinal detachment and neuromotor developmental delay. The first case, diagnosed in the early months of life, underwent successful retinal reattachment surgery. However, surgery was not performed on the second case, who presented with late-stage unilateral retinal detachment and pre-phthisis. Conclusions The report describes two patients with Knobloch syndrome, one of whom responded favorably to surgery for retinal detachment in both eyes. Successful anatomical results were achieved with early surgical interventions. It is essential to recognize the phenotypic and genetic heterogeneity within KNO.

The refurbishment of industrial heritage structures offers economic benefits and provides future generations with an insight into the industrial history of cities. However, industrial heritage projects possess unique attributes and risks, and the procedures for restoring, renovating, and converting these structures differ from those of other construction projects and their impacts to society. From the view of Social Impact Management, ISO 45001, ISO 14001, ISO/DIS 14001 and similar standards directly related with the sustainability. However, the design and method of construction are also important not only for workers’ safety but also public health and safety. For a holistic view Building Information Modeling provides us to gather information to reduce these concerns. This short communication covers societal impacts of a recently completed project in Germany that titled as Building Information Modeling (BIM) based sustainability, facility management and design for safety of industrial heritage buildings restoration/renovation projects and tries to put forward health and safety risks of Gasholder Restoration Projects to workers as well as to public during the project and after the completion by the aid of on site observations and expert panel discussions.

The new excavations started in 2007 at Beycesultan Höyük, an important center for understanding the Late Bronze Age cultural process in Western Anatolia, has provided important data for reevaluating the Late Bronze Age chronology in the region and understanding regional relations. The excavations in mound’s western and eastern cones have added new data to our knowledge of Late Bronze Age architecture, space utilization, and settlement planning. Especially the multi-roomed buildings with mudbrick walls with stone foundations and built adjacent to each other in both cones played an important role in understanding the architectural tradition. Compared to the western cone, the Late Bronze Age research in the Eastern Cone, where the studies are still at the beginning stage, contributes to understanding this cultural process in the settlement with the information it provides as a complementary element of the cultural process in the western cone. The presence of pottery from the Hittite period and Hittite-influenced finds identified in a large space during the studies conducted in this area appear as the archaeological reflection of the Hittite presence in the settlement.

The present study aimed to test the validity and reliability of the Club Aggression Scale developed by Shuv-Ami and Toder-Alon (2021) for Turkish culture. The study group consisted of 241 football fans. The measurement tool was adapted to Turkish culture with the translation/back translation method. In the research, exploratory factor analysis, confirmatory factor analysis and reliability values of the data were assessed. The fit index values (SRMR, CFI, AGFI, IFI, GFI, TLI) were also examined. In addition, AVE and CR values were assessed for construct reliability. As a result, it was concluded that the Turkish adapted version of the Club Aggression Scale is a valid and reliable measurement tool.

INTRODUCTION: The global COVID-19 pandemic has led to significant changes in emergent and elective treatment approaches in medical field, including ophthalmology. The aim of our study is to evaluate the indications, anatomical, and visual results of vitreoretinal surgery (VR) procedures performed during the pandemic and quarantine period. METHODS: VR procedures applied in the treatment of various retinal diseases in a tertiary eye hospital between March 11th and May 31st, 2020, during the COVID-19 pandemic and quarantine period were retrospectively reviewed. Indications of the applications, anatomical and visual results, and surgical complications were evaluated. RESULTS: In this period, 197 (59%) of 335 patients who underwent VR procedure were male, 138 (41%) were female. VR procedure was performed frequently in rhegmatogenous retinal detachment (48.6%) cases, followed by diabetic tractional retinal detachment (14.0%), complicated vitreous hemorrhage (11%), silicone oil extraction due to silicon-related complications (10%), endophthalmitis (7.5%), vitreoretinal pathologies secondary to trauma (5.8%), nucleus drop (2.1%), and intraocular lens drop (1.5%) cases. The pre-operative mean best corrected visual acuity of cases increased from 0.021+-0.167 to 0.258+-0.213 (p=0.042) logMAR. Local anesthesia was applied to 255 (76.1%) and general anesthesia to 80 (23.9%) of the patients who underwent VR in guideline adhered operating rooms. About 95% (n=318) of the patients were anatomically successful and the retina was reattached. Intraocular pressure fluctuations were the most common complication in patients. Elevated intraocular pressure was observed in 9.8% of the patients who underwent treatment for RRD, and hypotonia was found in 9.3% of the patients who underwent silicone oil extraction. DISCUSSION AND CONCLUSION: The visual and anatomical success and complication rates of VR procedures during the COVID-19 period are similar to pre-pandemic period. If appropriate protection, ventilation, and operating room conditions are provided, the risk of contamination for healthcare workers and patients can be minimized and VR interventions may be safely applied.

Kur’ân’da ve hadîslerde bazı yiyecek ve içeceklerin haram oluşu herhangi bir şarta bağlanmaksızın sarahaten ifade edilmektedir. Mâide suresinin 93. ayetinde ise “ittika, iman ve salih amel şartlarını taşıyanlara yedik ve içtiklerinden dolayı bir günahın olmadığı” haber verilmektedir. Bu durum Mâide suresi 93. ayetle sair ayet ve hadisler arasında zahiren bir işkâle sebep olmaktadır. Bu çalışmanın amacı ilgili ayetler arasında herhangi bir işkâlin olmadığını göstermektir. Nitekim Mâide suresinin 93. ayeti gerek sebeb-i nüzûlü, gerekse dinin bütünlüğü, aklî deliller ve metnin iç bağlamı açısından değerlendirildiğinde, ortada bir işkâlin olmadığı görülmektedir. İlgili ayet içki haram kılınmadan önce içki içenlere herhangi bir günahın olmadığını haber vermek üzere indirilmiştir. Bununla birlikte ayeti ve ayette verilen mesajları sebeb-i nüzûl rivayetleri çerçevesinde hususi olarak anlamak da doğru değildir. Ayette verilen mesajları günümüze de taşımamız gerekmektedir. Bu mesajlar üzerine düşünüldüğünde yiyecek ve içeceklerin kazanımı hususunda helal-haram sınırlarına azami derecede dikkat edilmesi gerekliliğiyle yiyecek ve içeceklerden elde edilen enerjinin diğer ihtiyaçlarla birlikte iman, ibadet ve salih amel noktasında kullanılması gerekliliği açık bir şekilde ortaya çıkmaktadır.

Background and Study Aim. The purpose of the study was to determine the relationship between leisure satisfaction, physical activity levels and healthy life-style behaviors of sport science students during the COVID-19 pandemic in distance education. Material and Methods. In total, 218 sport science students participated in this study voluntarily. The short form of International Physical Activity Questionnaire was administered for the determination of physical activity level of distance education students. Their physical activity levels were categorized as inactive, minimally active, and physically active by using Metabolic Equivalent Term method. Health-promoting Life-style Profile Questionnaire was used with self-actualization, health responsibility, exercise, nutrition, interpersonal support, and stress management subscales. The leisure satisfaction scale was administered for the determination of leisure satisfaction. Results. Results of Pearson’s Product Moment Correlation Analyses indicated that there were positive significant correlations between “HLSB” and three sub-dimensions of “IPAQ” (MIA, VIA and Total). It was found positive correlation between “HLSB” and all sub-dimensions of “LSS” (Psychological, Educational, Social, Relaxation, Physiological and Aesthetical). Also, a significant positive correlation was found between four sub-dimensions of “LSS” (Social, Relaxation, Physiological and Aesthetical) and one sub-dimensions of “IPAQ” (W). It was observed that one sub-dimensions of “LSS” which is “Aesthetical”, and a positive correlation between all sub-dimensions of “IPAQ” was found. Conclusions. The findings of the present study indicated that healthy life-style behaviors were indicators of LSS and IPAQ and also aesthetical was found between IPAQ of sport science students.

AIM: To compare two different anti-vascular endothelial growth factor (anti-VEGF) treatment regimens’-a priori pro re nata (PRN) and PRN regimen following the loading phase-anatomical and functional results in neovascular age-related macular degeneration (nAMD) patients. METHODS: Totally 544 nAMD patients followed and treated with aflibercept (n=135) and ranibizumab (n=409) at 9 different centers between 2013 and 2015 were enrolled into this retrospective multicenter study. Patients with initial best corrected visual acuity (BCVA) interval of 1.3-0.3 (logMAR) and a minimum follow-up of 12mo were included. Patients under two different regimens-a priori pro re nata (1+PRN) or 3 consecutive intravitreal injections followed by a PRN regimen (3+PRN)-were compared in BCVA at 3th, 6th and 12th months, and in central macular thickness (CMT) at 6th and 12th months. The total study group, intravitreal ranibizumab (IVR) and intravitreal aflibercept (IVA) groups were evaluated separately. RESULTS: The mean CMT decreased in the 1+PRN (n=101) regimen from 407 to 358 and 340 µm and in the 3+PRN (n=443) group from 398 to 318 and finally to 310 µm at months 6 and 12, respectively. Anatomically, the CMT reduction at 6th month (48.5 vs 76.4; P

INTRODUCTION[|]Branch retinal vein occlusion (BRVO) is the second most common type of retinal vascular disorder. Both inflammation and increased vascular endothelial growth factor (VEGF) levels play important roles in the pathogenesis of macular edema (ME) secondary to BRVO. The aim of this study was to compare the efficacy of 0.7-mg intravitreal dexamethasone implants with continued anti-VEGF treatment in patients with ME secondary to BRVO who were poor responders to at least 6 previous anti-VEGF injections.[¤]METHODS[|]Patients exhibiting an insufficient response to at least 6 ranibizumab treatments and who subsequently underwent a dexamethasone implant were included Group 1. Patients who were at risk for cataract or glaucoma continued treatment with the same drug and were defined as Group 2. The best corrected visual acuity (BCVA) and central macular thickness (CMT) changes at month 2, 4, and 6 were measured.[¤]RESULTS[|] Ninety eyes were evaluated. In Group 1, the mean baseline BCVA of 0.71+-0.75 logarithm of the minimum angle of resolution (logMAR) improved to 0.53+-0.62 logMAR at month 2 (p

Abstract Background To evaluate the surgical outcomes of vitrectomy in patients with foveal herniation associated with epiretinal membrane (ERM). Methods This was a retrospective case series. The patients who had a foveal herniation associated with ERM, underwent vitrectomy, and had a minimum follow-up period of 12 months were included. The visual and anatomical outcomes were assessed during the first 12 months of follow-up and at the last follow-up visit. The main outcome measure was the reorganization pattern of foveal pit at month 12. Results Eleven eyes of 11 patients were included. The mean postoperative follow-up period was 14.8 ± 2.6 months. The foveal contour was completely restored in 5 eyes (45.5%), partially restored in 5 eyes (45.5%), and was not restored in 1 eye (9.1%) at postoperative month 12 follow-up visit. The mean preoperative best corrected visual acuity was 0.61 ± 0.16 LogMAR and increased to 0.49 ± 0.16 LogMAR at month 12 (p

Objectives: To evaluate the real-world outcomes of intravitreal anti-vascular endothelial growth factor (anti-VEGF) treatment in neovascular age-related macular degeneration (nAMD) patients. Materials and Methods: Multicenter, retrospective, interventional, non-comparative study. The records of nAMD patients treated with an anti-VEGF agent on a pro re nata treatment regimen basis between January 2013 and December 2015 were reviewed. The patients who completed a follow-up period of 12 months were included. Primary outcome measures of this study were the visit and injection numbers during the first year. Results: Eight hundred eighty eyes of 783 patients met the inclusion criteria for the study. Mean number of visits at month 12 was 6.9±2.5 (range: 1-15). Mean number of injections at month 12 was 4.1±1.9 (range: 1-11). Mean visual acuity at baseline and months 3, 6, and 12 was 0.90±0.63 LogMAR (range: 0.0-3.0), 0.79±0.57 LogMAR (range: 0.0-3.0), 0.76±0.57 LogMAR (range: 0.0-3.0), and 0.79±0.59 LogMAR (range: 0.0-3.0), respectively. Mean central retinal thickness at baseline and months 6 and 12 was 395±153 μm (range: 91-1582), 330±115 μm (range: 99-975), and 332±114 μm (range: 106-1191), respectively. Conclusion: The numbers of visits and injections were much lower than ideal and were insufficient with the pro re nata treatment regimen.

Aim: Metabolic acidosis is the most serious complication of methanol intoxication, which needs urgent treatment. The aim of this study was to investigate effects of “Trometamol; Tris-hydroxymethylaminomethane” (THAM) and “Sodium Bicarbonate” (NaHCO3) treatments on mortality and survival time in rats with metabolic acidosis induced by intragastric-administered methanol.Materials and Methods: In 21 rats, a cannula was inserted in the right common carotid artery; the esophagus of each rat was penetrated with a branul. Baseline arterial blood gas samples were taken, and a 6 g/kg dose of methanol was injected into the cannula in the esophagus. The rats with confirmed acidosis were separated into three groups as “THAM,” “NaHCO3,” and “control” for the treatments. The control group received no medication, and the THAM and NaHCO3 groups were administered corresponding treatments intravenously.Results: A statistically significant difference was determined between the survival times of the THAM and NaHCO3 groups (p=0.036) and the THAM and control groups (p=0.002).Conclusion: The results of this study support the use of THAM, which is a biological, low-toxicity, inert amino alcohol, instead of NaHCO3 in the treatment of metabolic acidosis induced by intragastric methanol intoxication.

INTRODUCTION[|]The aim of this study was to evaluate the functional and anatomical outcomes and the rate of epiretinal membrane (ERM) recurrence in eyes that had undergone ERM-internal limiting membrane (ILM) peeling surgery at least 6 months earlier.[¤]METHODS[|]The records of 81 eyes of 81 patients who underwent pars plana vitrectomy (PPV) and ERM-ILM peeling with the diagnosis of idiopathic ERM between January 2015 and January 2016 in our clinic were retrospectively reviewed. Patients with at least 6 months of follow-up were included. The demographic details of the patients, duration of the follow-up period, use of endotamponade, and any complications were recorded. Best corrected visual acuity and central macular thickness (CMT) at baseline and at 6, 12, and 18 months were also recorded.[¤]RESULTS[|]A total of 81eyes of 81 patients, 45 (55.6%) males and 36 (44.4%) females, with a group mean age of 65.7+-8.5 years (range: 46-85 years) were assessed. The mean preoperative visual acuity was 0.81+-0.50 logMAR (the logarithm of the minimum angle of resolution) (0.22 decimals). During the follow-up, the mean visual acuity at 6, 12, and 24 months was 0.61+-0.37 logMAR (0.33 decimals), 0.61+-0.38 logMAR (0.33 decimals), and 0.55+-0.33 logMAR (0.36 decimals), respectively. The visual acuity was significantly better at 6,12, and 24 months compared with the baseline measurement (p

Asbest maddesi ve insan sağlığına verdiği zararlar iş sağlığı ve güvenliği dünyasında uzun süredir araştırmacıları meşgul etmektedir. Getirilen yasal düzenlemeler ile asbest kullanımı dünya genelinde birçok ülkede yasaklansa da geçmiş yıllardaki yaygın kullanımından dolayı mevcut bina stoklarında hala asbest ihtiva eden bileşenlerin var olduğu bilinmektedir. Son yıllarda Türkiye’de uygulaması devam eden kentsel dönüşüm süreci kapsamında bu binaların yıkımı söz konusu olduğu için asbeste maruz kalma gerçeği bir kez daha gün yüzüne çıkmıştır. Bu çalışmada, ülkemizde ve dünyada iş sağlığı ve güvenliği kapsamında asbest maruziyetine yönelik yapılan yasal düzenlemeler detaylı olarak incelenmiş ve yapılan karşılaştırmalar sonucunda elde edilen bulgulara göre mevzuatta daha etkili önlemlerin alınması gerektiği ve kontrol mekanizmasının geliştirilmeye ihtiyaç duyduğu kanısına varılmıştır. Bu kapsamda kentsel dönüşüm sürecinde asbest maruziyetine uğramamak için uygulamacılarca kullanılabilecek bir akış şeması oluşturulmuş ve çözüm önerileri sunulmuştur.

The Argus II Retinal Prosthesis System (Second Sight Medical Products, Inc., Sylmar, CA, USA) is the first US Food and Drug Administration-approved retinal implant. It provides electrical stimulation of the retina and induces visual perception in individuals with low vision. It is used in patients with severe disease, such as retinitis pigmentosa (RP). Presently described is Argus II implantation in a patient with RP.

This report is a description of a surgical technique for optic disc maculopathy (OPM). Pars plana vitrectomy combined with internal limiting membrane (ILM) peeling, reverse ILM flap insertion into optic pit, and gas tamponade surgery was performed on 5 patients with OPM. Preliminary outcomes of the technique were promising.

In this surgical technique report, the advantages of use of vitreous cutters with smaller diameters as vitreoretinal surgical instruments and choroid-RPE patch transplantation that was performed with combination of 23- and 25-gauge vitrectomy systems are described.

INTRODUCTION[|]The present study is an evaluation of outcomes of 23-gauge pars plana vitrectomy (PPV) performed to ex- tract dislocated lens fragments without phacofragmentation after complicated cataract surgery.[¤]METHODS[|]In a consecutive case series, 50 eyes that underwent 23-gauge PPV without use of phacofragmatome were retrospectively reviewed.[¤]RESULTS[|]Visual acuity (VA) improved from preoperative 20/250 to 20/57 final VA (p

INTRODUCTION[|]The present study evaluated treatment outcomes of intravitreal ranibizumab (IVR) use in patients with macular edema (ME) secondary to retinal vein occlusion (RVO), and mean number of visits and injections of first year of treatment.[¤]METHODS[|]The study was a retrospective case series. Newly diagnosed RVO patients who had macular edema for

Macular holes can develop as result of intraocular inflammatory disease, trauma, or vitreous detachment, among other reasons. Presently described is case of full-thickness macular hole (FTMH) repair after successful surgery for traumatic submacular hemorrhage. FTMH may have developed due to injection of small air bubble into the subretinal space during surgery to remove subretinal hemorrhage. FTMH was successfully treated with pars plana vitrectomy and internal limiting membrane (ILM) removal using gas tamponade, as in cases of traumatic/idiopathic macular hole.

Objectives: To evaluate the efficacy of intravitreal bevacizumab treatment in type 2 idiopathic macular telangiectasia (IMT). Materials and Methods: Six eyes of 5 patients with type 2 IMT who received intravitreal bevacizumab between 2009 and 2014 were included in this study. All the patients had an ophthalmological examination including best corrected visual acuity (BCVA), dilated fundus examination, spectral domain optical coherence tomography (OCT) and fluorescein angiography. Intravitreal bevacizumab injection was planned for patients who had macular edema and/or decreased visual acuity at baseline. Patients were examined 1 week and 1 month after the intravitreal injection. Intravitreal injection was repeated in patients whose visual acuity decreased and/or whose macular edema persisted or increased. Changes in BCVA, central macular thickness (CMT) and central macular volume from baseline at 1 month after the first injection and at final examination were evaluated. Results: Average age of the patients (4 female and 1 male) was 62±11.8 years. Average follow-up period was 26±11 months. Patients received an average of 2.3 (range 1-4) injections during follow-up. Average Snellen BCVA of the patients was 0.48±0.29. BCVA increased at final examination compared to baseline in all of the patients. The difference between baseline and final visual acuities was significant (p

Objectives: We investigated the demographic characteristics, clinical and laboratory findings, treatment strategies and clinical outcomes of patients presenting at emergency department (ED) with digoxin levels at or above 1.2 ng/ml. Materials and methods: The demographic and clinical characteristics of patients with serum digoxin levels at or above 1.2 ng/ml admitted to an ED between January 2010 and July 2011 were investigated in this cross-sectional descriptive study. Patients with ECG and clinical findings consistent with digoxin toxicity and no additional explanation of their symptoms were evaluated for digoxin toxicity. Results: In this study 137 patients were included, and 68.6% of patients were women with mean age 76.1 ± 12.2. There was no significant difference between gender and digoxin intoxication. The mean age of intoxicated group was significantly higher than the non-intoxicated group (P = 0.03). The most common comorbidities were congestive heart failure (n = 91) and atrial fibrillation (n = 74). The most common symptoms were nausea, vomiting and abdominal pain. The levels of hospitalization and mortality in this group were significantly higher. Conclusion: Digoxin intoxication must be suspected in patients present in the ED, particularly those with complaints that include nausea and vomiting, as well as new ECG changes; serum digoxin levels must be determined. Keywords: Digoxin, Digoxin level, Intoxication, Emergency department

Purpose: To compare the outcomes of treatment with intravitreal bevacizumab (IVB) versus observation in central serous chorioretinopathy (CSCR). Methods: In a retrospective comparative study, records of 45 patients with CSCR were reviewed. Twenty-two patients received IVB (1.25 mg/0.05 ml) while 23 subjects were observed. All subjects underwent measurement of best corrected visual acuity (BCVA) and intraocular pressure (IOP), dilated fundus examination and optical coherence tomography (OCT) imaging at baseline and follow up visits. Outcome measures included central macular thickness (CMT) and BCVA in logarithm of minimum angle of resolution (logMAR) notations. Results: Mean age was 44.1 ± 9.3 (range: 24 to 64) years and mean follow-up period was 10.4 ± 11.2 (range: 3 to 43; median: 6) months. All patients demonstrated resolution of neurosensory detachment and improvement in visual acuity. At final visit, there was no significant difference in mean CMT between the IVB and observation groups (275 vs 284 μm, P> 0.05). Mean baseline logMAR visual acuity was 0.38 ± 0.24 in the IVB group which improved to 0.24 ± 0.31 at final follow-up (P = 0.011); mean baseline logMAR visual acuity was 0.42 ± 0.28 in the observation group and improved to 0.12 ± 0.18 (P = 0.001). Visual improvement was more marked in the observation group (0.30 vs 0.14 logMAR, P< 0.05) and mean final visual acuity was also significantly better (P = 0.05). Conclusion: There was no significant difference between IVB injection and observation in terms of anatomical outcomes of treatment for CSCR. In terms of visual outcomes, observation was superior to IVB injection.

AIM:To describe the clinical characteristics of Turkish patients with intermediate uveitis (IU) and to investigate the effect of clinical findings and complications on final visual acuity (VA).METHODS:We retrospectively analyzed the medical records of patients with IU who had at least 6mo of follow-up and were older than 16y.RESULTS:A total of 78 eyes of 45 patients were included in the study and the mean follow-up period was 19.4mo. The mean age at the time of presentation was 42.9s. Systemic disease associations were found in 17.7% of cases; sarcoidosis (8.8%) and multiple sclerosis (6.6%) were the most common diseases. Recurrence rate (odds ratio=45.53; 95%CI:2.181-950.58), vitritis equals to or more than 3+ cells (odds ratio =57.456; 95%CI:4.154-794.79) and presenting with VA less than 20/40 (odds ratio =43.81; 95%CI:2.184-878.71) were also found as high risk factors for poor final VA. At the last follow-up examination, 67.9% of eyes had VA of 20/40 or better.CONCLUSION: IU is frequently seen at the beginning of the fourth decade of life. The disease is most commonly idiopathic in adult Turkish patients. Patients with severe vitritis at presentation and patients with frequent recurrences are at high risk for poor visual outcome.

The purpose of this study was to examine the relationship between superstitious behavior in sport and trait anxiety levels among college students engaged in active sports. 166 Pamukkale University and Ege University of School of Physical Education and Sports students who are selected simple random sampling method voluntarily participated (61 females and 105 males) for the study. In the study for gathering data “Superstitious Ritual Questionnaire” and “Trait Anxiety Inventory” were used together. To examine the relationship between superstitious behavior in sport and trait anxiety levels the Pearson product-moment coefficients of correlation was used. The results indicated that the relationship between superstitious behavior in sport and trait anxiety level is positive and statistically significant (r=.208; p=.007). To explain whether there are significant differences between participants’ superstitious behavior in sport according to gender, Independent Sample T-test was used. Result of this analysis revealed no statistically significant difference between male and female students tendency to superstitious behaviors according to gender (t=1.15; p=.251). In conclusion study findings showed that anxiety is a factor that increases university students, engaging in active sport, superstitions behavior.

AbstractObjective: This study evaluates the impact of a physical activity (PA) intervention program on body composition and anthropometrical measurements among middle aged, overweight and obese women. Methods: This was an interventional study in a semi-urban area. Sample size was calculated as 85 women for each group. The overweight and obese women were assigned to one of two groups by randomization on the basis of a cross-sectional study. Women from both groups participated in a training program on healthy life styles. The intervention group participated in a PA program for three months, three times a week. Anthropometrical and bioelectrical impedance analysis (BIA) measurements were performed at the beginning and repeated on 6th and 12th weeks for each group. The Chi square test, Fisher’s exact test, Student’s T test and variance analysis on repeated measures were used for data analysis. Results: Intervention and control groups were similar at the baseline evaluation in terms of their socio-demographic and BIA characteristics. There were statistically significant decreases in both groups in terms of BIA indicators, while body fat percent and trunk fat weight remained unchanged in the control group. When reductions between first and last measurements were compared, for all BIA indicators except for maximum effort capacity scores, muscle weight and body fat percent; the differences were statistically significant in the intervention group. Reductions in body weight, BMI and waist circumference for women who participated in 30 or more PA sessions were higher than for those who participated in 29 or fewer sessions. Conclusions: This PA intervention program was effective for middle aged overweight or obese women in terms of improvement on anthropometrical determinants of obesity. This intervention program can be offered as an appropriate model for similar groups.Key Words: Obesity, intervention study, health promotion, physical activity.