110 results on '"Günen, Hakan"'
Search Results
2. Distribution of alpha1 antitrypsin rare alleles in six countries: Results from the Progenika diagnostic network.
- Author
-
Lopez-Campos, José Luis, Rapun, Noelia, Czischke, Karen, Jardim, José R., Acquier, Mariano Fernandez, Munive, Abraham Ali, Günen, Hakan, Drobnic, Estrella, Miravitlles, Marc, and Osaba, Lourdes
- Abstract
Background: Knowledge of the frequency of rare SERPINA1 mutations could help in the management of alpha1 antitrypsin deficiency (AATD). The present study aims to assess the frequencies of rare and null alleles and their respiratory and hepatic pathogenicity. Methods: This is a secondary analysis of a study that evaluated the viability of the Progenika diagnostic genotyping system in six different countries by analyzing 30,827 samples from cases of suspected AATD. Allele-specific genotyping was carried out with the Progenika A1AT Genotyping Test which analyses 14 mutations in buccal swabs or dried blood spots samples. SERPINA1 gene sequencing was performed for serum AAT-genotype discrepancies or by request of the clinician. Only cases with rare mutations were included in this analysis. Results: There were 818 cases (2.6%) carrying a rare allele, excluding newly identified mutations. All were heterozygous except for 20 that were homozygous. The most frequent alleles were the M-like alleles, PI*M
malton and PI*Mheerlen . Of the 14 mutations included in the Progenika panel, there were no cases detected of PI*Siiyama , PI*Q0granite falls and PI*Q0west . Other alleles not included in the 14-mutation panel and identified by gene sequencing included PI*Mwürzburg , PI*Zbristol , and PI*Zwrexham , and the null alleles PI*Q0porto , PI*Q0madrid , PI*Q0brescia , and PI*Q0kayseri . Conclusions: The Progenika diagnostic network has allowed the identification of several rare alleles, some unexpected and not included in the initial diagnostic panel. This establishes a new perspective on the distribution of these alleles in different countries. These findings may help prioritize allele selection for routine testing and highlights the need for further research into their pathogenetic role. [ABSTRACT FROM AUTHOR]- Published
- 2023
- Full Text
- View/download PDF
3. Additional file 1 of Feasibility of a genotyping system for the diagnosis of alpha1 antitrypsin deficiency: a multinational cross-sectional analysis
- Author
-
Lopez-Campos, José Luis, Osaba, Lourdes, Czischke, Karen, Jardim, José R., Fernandez Acquier, Mariano, Ali, Abraham, Günen, Hakan, Rapun, Noelia, Drobnic, Estrella, and Miravitlles, Marc
- Abstract
Additional file 1: Supplementary material.
- Published
- 2022
- Full Text
- View/download PDF
4. Are Lymphocytes and Eosinophils Associated with the COVID-19 Severity: A Large, Retrospective Study.
- Author
-
Duman, Dildar, Karakurt, Zuhal, Koçak, Nagihan Durmuş, Adıgüzel, Nalan, Güngör, Tekin Yıldız Gökay, Takır, Huriye Berk, Tepetam, Fatma Merve, and Günen, Hakan
- Subjects
EOSINOPHILS ,BIOMARKERS ,INTENSIVE care units ,COVID-19 ,SCIENTIFIC observation ,CROSS-sectional method ,CRITICALLY ill ,PATIENTS ,RETROSPECTIVE studies ,SEVERITY of illness index ,HOSPITAL admission & discharge ,RISK assessment ,LOGISTIC regression analysis ,LYMPHOCYTE count ,MEDICAL needs assessment - Abstract
OBJECTIVE: Coronavirus disease 2019 is an ongoing disease with high morbidity and mortality. We aimed to investigate the relationship between demographics, lymphocytes, eosinophils, and the coronavirus disease 2019 severity at hospital admission. MATERIAL AND METHODS: A retrospective, observational cross-sectional study was carried out with 5828 coronavirus disease 2019 patients between March 11, 2020, and November 30, 2020. Patients were divided into 3 groups according to where they were followed up as an indicator of disease severity, namely outpatients, inpatients, and critically ill patients. The patients' demographics and hemogram values on admission were recorded. The predictive accuracies of lymphocyte count, lymphocyte percentage, eosinophil count, and eosinophil percentage for predicting severity were determined using receiver operating characteristic curves. Logistic regression analysis was used to predict intensive care unit demand according to lymphocyte and eosinophil values. RESULTS: Of the 5828 coronavirus disease 2019 patients, 4050 were followed up as outpatients, 1581 were hospitalized in a ward, and 197 were hospitalized in the intensive care unit. Lymphocyte count and lymphocyte percentage were significantly different between the groups, but the difference for eosinophil count and eosinophil percentage was not significant as it was for lymphocytes. Cutoff values for lymphocyte count (1.0 - 109/L), lymphocyte percentage (22%), eosinophil count (0.052 x 109/L), and eosinophil percentage (0.08%) were found to indicate a high risk for intensive care unit admission. Coronavirus disease 2019 patients >55 years of age, with a lymphocyte count <1.0 x 109/L, a lymphocyte percentage <22%, and an eosinophil percentage <0.08% had a 2-fold higher risk of requiring intensive care unit management. CONCLUSION: Lymphocyte counts and percentages are quick and reliable biomarkers for predicting coronavirus disease 2019 severity and may guide physicians for proper management earlier. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
5. Demographic, Clinical and Management Characteristics of Newly Diagnosed COPD Patients in Turkey: A Real-Life Study
- Author
-
Suerdem, Mecit, Günen, Hakan, Akyıldız, Levent, Çilli, Aykut, Özlü, Tevfik, Uzaslan, Esra, Mısırlıgil, Zeynep, and İÜC, Cerrahpaşa Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü
- Subjects
exacerbations ,treatment naive ,COPD ,newly diagnosed - Abstract
WOS:000515242300001 PubMed ID: 32103925 Purpose: In order to determine the clinical and sociodemographic characteristics of newly diagnosed treatment-naive asthma and COPD patients in Turkey, a multicenter study in 2012 was initiated. We aimed to investigate the characteristics and therapies of COPD patients in the original study in more detail. Patients and Methods: This nation-wide, multicentric, non-interventional, prospective, real-life observational cohort study was conducted in 122 centers. The newly diagnosed patients were not receiving any treatment before the recruitment. Their general characteristics, the combined GOLD 2011 COPD categories and exacerbation histories were noted. The patients were followed up with 3 voluntary visits for 1 year. Their adherence to the inhaled treatment according to GOLD 2011 was evaluated during follow-up visits. Results: The study included 776 COPD patients. Their mean age was 59.4 +/- 9.1 years, and 11.9% of the patients were female. 35.1% of the patientswere in the GOLD 2011 C and D category. 12.6% are frequent exacerbators, and 52.8% had at least one comorbid condition. 71.8% overtreatment rate was detected. Their attendance rates for three follow-up visits became 55.9%, 32.9% and 18.7%, respectively. The adherence rate to the treatment was measured as 81.9%. Conclusion: Although these patients were diagnosed for the first time, the GOLD C and D categories and frequent exacerbator phenotype were found at a high rate. They were usually prescribed an overtreatment regimen. We think that newly diagnosed COPD patients should be evaluated carefully, and best effort should be made to treat these patients in accordance with the recommendations of the major COPD guidelines. Abdi Ibrahim Ilac San. ve Tic. AS, Turkey; Abdi Ibrahim; Sanofi; AstraZenecaAstraZeneca; NovartisNovartis; Deva The study is financially supported by "Abdi Ibrahim Ilac San. ve Tic. AS, Turkey." All authors are members of the advisory board of the study and received payment from "Abdi Ibrahim Ilac San. ve Tic. AS, Turkey" for this. Professor Hakan Gunen reports non-financial support from AbdiIbrahim Pharmaceutical Company, during the conduct of the study; AbdiIbrahim Turkey Pharmaceutical Company paid the publication processing fee, outside the submitted work. Dr Tevfik Ozlu reports personal fees from Abdiibrahim, during the conduct of the study; Prof. Dr. Oznur Abadoglu reports grants from Abdi Ibrahim, during the conduct of the study. Dr Bilun Gemicioglu reports Clinical research grants from Sanofi, AstraZeneca, Novartis; Consultancy or lecture grants from Abdi Ibrahim, Deva, Novartis, during the conduct of the study. Prof. Dr. Zeynep Misirligil report grants, personal fees from Abdi Ibrahim Ilac San. ve Tic. AS, during the conduct of the study. The authors report no other conflicts of interest in this work.
- Published
- 2020
6. Validity and Reliability of Turkish Version of Reaction Type Scale Against COPD.
- Author
-
Gürhan, Nermin, Eroğlu, Selma Aydoğan, Polat, Ülkü, Kaya, Emel, Köktürk, Nurdan, Şirin, Burak, and Günen, Hakan
- Subjects
EXPERIMENTAL design ,STRUCTURAL equation modeling ,RESEARCH evaluation ,SPIRITUALITY ,RESEARCH methodology ,RESEARCH methodology evaluation ,SEVERITY of illness index ,OBSTRUCTIVE lung diseases ,PUBLIC hospitals ,SCALE analysis (Psychology) ,FACTOR analysis ,PROPRIETARY hospitals ,STATISTICAL correlation ,EMOTIONS - Abstract
OBJECTIVE: The aim of the study is to develop a scale that could assess illness perception and reaction in patients with chronic obstructive pulmonary disease (COPD). MATERIAL AND METHODS: The study was conducted in patients who were admitted in the pulmonary disease departments of a public and a private hospital. The study included 271 COPD patients. The COPD Perception and Reaction Scale, consisting of 54 items, was prepared as a Likert-type 5-point rating scale. In the validity phase of the study, expert judgments were obtained for content validity, and explanatory and confirmatory factor analyses (EFA and CFA) were then performed. The reliability of the scale in terms of internal consistency was tested with the Cronbach's alpha coefficient. RESULTS: According to the results of the EFA, the COPD Perception and Reaction Scale consists of 3 subdimensions and 23 items. Factors are termed behavioral reaction, emotional reaction, and spiritual reaction. According to the CFA, the goodness-of-fit indices obtained (χ2/df = (676.47/227) 2.98 and RMSEA = 0.056, NFI = 0.80, CFI = 0.96, NFI = 0.91, and AGFI = 0.85) suggest that the recommended model for the scale is acceptable. The Cronbach's alpha coefficient was 0.74; Cronbach's alpha values for the subdimensions were calculated as 0.87 for "emotional reaction," 0.76 for "behavioral reaction," and 0.79 for "spiritual reaction." CONCLUSION: The 23-item form of the COPD Illness Perception and Reaction Scale was demonstrated to be a valid and reliable scale for determining the perception and the reaction toward illness in COPD patients in Turkey. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF
7. The Role of Pneumococcal Pneumonia among Community-Acquired Pneumonia in Adult Turkish Population: TurkCAP Study.
- Author
-
Şenol, Esin, Çilli, Aykut, Günen, Hakan, Şener, Alper, Dumlu, Rıdvan, Ödemiş, Ayşe, Topçu, Ayşe Füsun, Yıldız, Yeşim, Güner, Rahmet, Özhasenekler, Ayhan, Mutlu, Birsen, Köktürk, Nurdan, Sevimli, Nurgül, Baykam, Nurcan, Yapa, Derya, Ekin, Selami, Polatlı, Mehmet, Gök, Şebnem Eren, Kılınç, Oğuz, and Sayıner, Abdullah
- Subjects
PNEUMONIA diagnosis ,PNEUMONIA ,RESEARCH ,CLINICAL pathology ,SCIENTIFIC observation ,NEUROLOGICAL disorders ,CONFIDENCE intervals ,CHRONIC diseases ,MEDICAL cooperation ,BACTERIAL antigens ,RADIOGRAPHY ,DESCRIPTIVE statistics ,OBSTRUCTIVE lung diseases ,CRITICAL care medicine ,SMOKING ,COMMUNITY-acquired pneumonia ,LONGITUDINAL method ,COMORBIDITY ,DISEASE complications ,MIDDLE age ,OLD age - Abstract
OBJECTIVE: To evaluate the rate of pneumococcal pneumonia (PP) among patients with community-acquired pneumonia (CAP) in Turkey and to investigate and compare features of PP and non-PP CAP patients. MATERIAL AND METHODS: This multicenter, non-interventional, prospective, observational study included adult CAP patients (age > 18 years). Diagnosis of PP was based on the presence of at least 1 positive laboratory test result for Streptococcus pneumoniae (blood culture or sputum culture or urinary antigen test [UAT]) in patients with radiographic findings of pneumonia. RESULTS: Four hundred sixty-five patients were diagnosed with CAP of whom 59 (12.7%) had PP The most common comorbidity was chronic obstructive pulmonary disease (30.1%). The mean age, smoking history, presence of chronic neurological disease, and CURB-65 score were significantly higher in PP patients, when compared to non-PP patients. In PP patients, 84.8% were diagnosed based ony on the UAT. The overall rate of PP patients among CAP was calculated as 22.8% considering the UAT sensitivity ratio of 63% (95% confidence interval: 45-81). The rate of intensive care treatment was higher in PP patients (P = .007). While no PP patients were vaccinated for pneumococcus, 3.8% of the non-PP patients were vaccinated (P = .235). Antibiotic use in the preceding 48 hours was higher in the non-PP group than in the PP group (31.8% vs. 11.1%, P = .002). The CURB-65 score and the rate of patients requiring inpatient treatment according to this score were higher in the PP group. CONCLUSION: The facts that PP patients were older and required intensive care treatment more frequently as compared to non-PP patients underline the burden of PP. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF
8. Validity and Reliability of Turkish Version of Reaction Type Scale against COPD
- Author
-
Gürhan, Nermin, primary, Aydoğan, Selma, additional, Polat, Ülkü, additional, Gür, Emel, additional, Köktürk, Nurdan, additional, Şirin, Burak, additional, and Günen, Hakan, additional
- Published
- 2019
- Full Text
- View/download PDF
9. Prevalence of malnutrition in COPD and its relationship with the parameters related to disease severity
- Author
-
Mete, Burak, primary, Pehlivan, Erkan, additional, Gülbaş, Gazi, additional, and Günen, Hakan, additional
- Published
- 2018
- Full Text
- View/download PDF
10. Validity and Reliability of the Assessment Tool for Asthma (ATA) Questionnaire: the ATA Study.
- Author
-
Gemicioğlu, Bilun, Mungan, Dilşad, Bavbek, Sevim, Yıldız, Füsun, Polatlı, Mehmet, Naycı, Sibel, Erkekol, Ferda Öner, Türker, Hatice, Günen, Hakan, Çamsarı, Güngor, Abadoğlu, Öznur, Çımrın, Arif, Dursun, A. Berna, Göksel, Özlem, Özdemir, Seçil Kepil, Börekci, Şermin, Aydın, Ömür, Ocaklı, Birsen, Gür, Aygün, and Baygul, Arzu
- Subjects
ASTHMA prevention ,STATISTICAL correlation ,RESEARCH methodology ,MEDICAL cooperation ,QUESTIONNAIRES ,RESEARCH ,RESEARCH evaluation ,STATISTICS ,DATA analysis ,VISUAL analog scale ,CROSS-sectional method ,RECEIVER operating characteristic curves ,RESEARCH methodology evaluation - Abstract
questionnaire, which evaluates both asthma control and risk factors associated with asthma control with a single instrument. MATERIALS AND METHODS: This cross-sectional study involved 810 cases from 14 clinics in 9 Turkish cities. The ATA questionnaire and Asthma Control Test (ACT) were administered. The Visual Analog Scale (VAS) was used to evaluate the control status of 100 randomized cases. ATA is an eight-item physician-administered questionnaire. It comprises the following two sections-ATA1, assesses symptomatic control criteria, and the remaining section, queries the flare-up of asthma, control of comorbidities, treatment adherence, and inhaler technique. RESULTS: The mean scores for ATA1, ATA total, VAS, and ACT were 24.7±14.8, 53.8±19, 7.1±3, and 18.8±5.5, respectively. According to the ATA questionnaire, among all patients, 34.3% had controlled, 18.8% had partly controlled, and 46.9% had uncontrolled asthma. Furthermore, 16.6% patients had flare-ups between visits, 96.4% patients had uncontrolled comorbidity, 17% patients had irregular asthma treatment, and only 8.4% patients used the incorrect inhaler technique. The ATA questionnaire showed internal consistency (Cronbach's alpha coefficient=0.683). ACT, ATA1, and two specialists' evaluations using VAS correlated strongly with the ATA total scores (Spearman correlation coefficient (r) values: 0.776, 0.783, and 0.909, respectively; p-values: p<0.001, p<0.001, and p<0.001, respectively). According to Receiver Operating Characteristic analysis, the cut-off value of ATA was 50 (sensitivity=84.4%, specificity=82.40%). CONCLUSION: The validated ATA questionnaire may be a practical tool for physicians in asthma management. [ABSTRACT FROM AUTHOR]
- Published
- 2020
- Full Text
- View/download PDF
11. The effect of comorbidities on long-term survival in COPD
- Author
-
Eroğlu, Selma Aydoğan, primary, Yakar, Halil Ibrahim, additional, Yıldız, Ethem, additional, Kavas, Murat, additional, Duman, Dildar, additional, and Günen, Hakan, additional
- Published
- 2018
- Full Text
- View/download PDF
12. Sulfasalazine Induced Eosinophilic Pneumonia
- Author
-
Aydoğan Eroğlu, Selma, primary, Günen, Hakan, additional, Yakar, Halil İbrahim, additional, and Duman, Dildar, additional
- Published
- 2018
- Full Text
- View/download PDF
13. Real life profile of asthma and chronic obstructive pulmonary disease patients in Turkey
- Author
-
Mısırlıgil, Zeynep, primary, Çımrın, Arif, additional, Günen, Hakan, additional, Özlü, Tevfik, additional, Çilli, Aykut, additional, Akyıldız, Levent, additional, Bayram, Hasan, additional, Gemicioğlu, Bilun, additional, Uzaslan, Esra, additional, Abadoğlu, Öznur, additional, and Suerdem, Mecit, additional
- Published
- 2017
- Full Text
- View/download PDF
14. A new definition: Combined pulmonary fibrosis and emphysema syndrome
- Author
-
Duman, Dildar, primary and Günen, Hakan, additional
- Published
- 2017
- Full Text
- View/download PDF
15. AKCİĞER TÜBERKÜLOZUNDA DOĞRUDAN GÖZETİMLİ TEDAVİ
- Author
-
GÜNEN, Hakan and KIZKIN, Özkan
- Subjects
Directly observed therapy,tuberculosis,treatment compliance ,Doğrudan gözetimli tedavi,tüberküloz,tedavi uyumu - Abstract
Prevalence of tuberculosis (TB), persistently having a downward trend until the beginning of 1980s in developed countries, re-surged with the appearance of AIDS, decrease of funding for health due to economical reasons in governmental policies, unequal distribution of the general capital, increase in dimensions of alcoholism, homelessness and illicit drug use. At the end of 1990s, these countries mainly the USA, one by one, declared to the world that they had lost the war against TB and immediate precautions should be taken. Just after that, they accepted Directly Observed Therapy (DOT), having an already demonstrated efficacy against TB with studies, which means giving the drugs by hand twice or thrice weekly and directly observing patients' swallowing as the standard treatment, even getting further as an obligation by laws. For our country, it is known by everybody that the war against TB was already lost and the problem of drug resistance reached enormous dimensions. Even according to optimistic statements in the official numbers, it is a fact that we are in a 2 fold worse situation in average than the worst situation of those countries already declaring that they had lost the war against TB. Starting off here, after the immediate completion of necessary organisation, DOT application, in contrary to the general prejudice indeed being cheaper and decreasing relapse and multi-drug resistance rates, seems the only solution to the problem as the standard and obligatory application by laws in our country too. In our review, considering the previous literature, we attempted to discuss DOT applications and results in the world and things to be done for this aspect in our country. Key words: Directly observed therapy, tuberculosis, treatment compliance, Bin dokuz yüz seksenlerin başına kadar gelişmiş ülkelerde sürekli azalma eğiliminde olan tüberküloz (TBC) prevalansı, bu tarihten sonra AIDS hastalığının ortaya çıkması, devlet politikalarında sağlığa ayrılan payın ekonomik nedenlerle azaltılması, toplumlardaki gelir dağılımının giderek bozulması ile birlikte alkolizmin, evsizliğin ve uyuşturucu kullanımının büyük boyutlara ulaşması gibi sebeplerle yükselmeye başlamıştır. 1990'ların sonuna gelindiğinde başta Amerika olmak üzere bu ülkeler tek tek TBC'ye karşı yaptıkları savaşı kaybettiklerini ve acil önlemler alınması gerektiğini tüm dünyaya ilan etmişlerdir. Hemen ardından ise yapılan çalışmalarla TBC ile mücadelede etkinliği çok daha önceden ispatlanmış olan ve hastalara haftada iki veya üç kez ilaçların elden verilmesi ve yuttuğunun gözlenmesi olarak tanımlanan Doğrudan Gözetimli Tedavi (DGT) uygulamasını standart tedavi olarak kabul etmişler ve hatta daha da ileri giderek kanunlarla zorunlu hale getirmişlerdir. Ülkemiz açısından ele alındığında ise TBC ile savaşın çoktan kaybedildiği ve ilaç direnci probleminin inanılmaz boyutlara ulaştığı herkesçe bilinmektedir. Resmi rakamlarda belirtilen iyimser tahminlere göre bile şu anda, savaşı kaybettiğini daha önce ilan eden ülkelerin en kötü halinden ortalama 2 kat daha kötü durumda olduğumuz bir gerçektir. Buradan yola çıkarak, TBC tedavisinde önyargıların aksine daha ucuza mal olan, relaps ve çok ilaca direnç oranlarını azaltan DGT uygulamasının gerekli organizasyonun acil olarak yapılmasını takiben ülkemiz için de resmi, standart ve kanuni olarak zorunlu uygulama haline getirilmesi tek çözüm gibi görünmektedir. Derlememizde daha önceki literatürler ışığında dünyadaki DGT uygulamalarını, sonuçlarını ve ülkemizde bu yönde neler yapılması gerektiğini tartışmaya çalıştık. Anahtar kelimeler: Doğrudan gözetimli tedavi, tüberküloz, tedavi uyumu
- Published
- 2015
16. ORTA VE AĞIR KOAHTA SİSTEMİK KORTİKOSTEROİDLERİN YERİ
- Author
-
GÜNEN, Hakan and KOŞAR, Feridun
- Subjects
COPD,Systemic Corticosteroid,Benefit ,KOAH,Sistemlk Kortikosteroid,Fayda - Abstract
Role of systemic corticosteroids (CS) ¡n treatment of chronic obstructive pulmonary diseases (COPD) is quite controversial. Considering side effects of systemic CS, their efficacy should be clearly documented with objective criteria before their chronic utilization. In our study, 25 grade II (n=20, FEV1 between 49 and 35%) and grade III (n=5, FEV1, Kronik obstrüktif akciğer hastalıklarının (KOAH) tedavisinde sistemlk kortikosteroidlerin (KS) yeri oldukça tartışmalıdır. Sistemlk KS'lerin yan etkilerinden dolayı kronik kullanımlarında kesin faydalı olduklarının objektif kriterlerle belirlenmesi esastır. Çalışmamızda toplam 25, evre II (n=20, FEV1:%49 He %35arasında) ve evre III(n=5, FEV1
- Published
- 2015
17. Right Aortic Arch Anomaly: A Case Report
- Author
-
S.HACIEVLİYAGİL, Süleyman, YETKİN, Özkan, GÜLBAŞ, Gazi, MUTLU, Levent, and GÜNEN, Hakan
- Subjects
Sağ aortik ark anomalisi,Akciğer grafisi,Toraks bilgisayarlı tomografisi ,Right aortic arch anomaly,Chest x-ray,Thorax computed tomography - Abstract
Right aortic arch anomaly (RAAA) is a seldomly encountered condition. As it may present with other vascular abnormalities, it may also present alone. It usually becomes symptomatic at childhood, and symptoms like dyspnea and dsyphagia, if there is compression on trachea or esophagus, may be encountered. Sometimes it is coincidentally diagnosed with radiological methods in asymptomatic individuals who were admitted to the hospital for other reasons. RAAA was diagnosed with by chest x-ray and dynamic thorax computed tomography for asymptomatic a 47 year-old woman who was admitted to the hospital due to a traffic accident. This patient was presented as a case report since it is a rarely seen syndrome diagnosed coincidentally in patients who remained asymptomatic for several years. Key words: Right aortic arch anomaly, Chest x-ray, Thorax computed tomography., Sağ aortik ark anomalisi (SAAA) nadir görülen bir durumdur. SAAA başka damarsal anomalilerle birlikte olabileceği gibi tek başına da olabilir. Genellikle çocuklukta semptomatik hale gelir, trakea veya özafagusa bası durumunda nefes darlığı, disfaji gibi şikayetlere yol açabilir. Bazen SAAA tanısı, semptom vermeksizin başka bir nedenle hastaneye başvuran kişilerde istenen radyolojik görüntüleme yöntemleri ile tesadüfen konulur. 47 yaşına kadar herhangi bir şikayeti olmayan bayan hastaya travma sonrası çekilen akciğer grafisi ve dinamik toraks tomografisindeki bulgulara dayanarak SAAA tanısı konuldu. SAAA az görüldüğü ve hastamız uzun yıllar semptom vermediği için olgu sunusu olarak sunulmuştur. Anahtar kelimeler: Sağ aortik ark anomalisi, Akciğer grafisi, Toraks bilgisayarlı tomografisi.
- Published
- 2015
18. Kot Kumlamaya Bağlı Olarak Gelişen İki Silikozis Olgusu
- Author
-
Ermiş, Hilal, Gülbaş, Gazi, Yumrutepe, Tuncay, İn, Erdal, Mutlu, Levent Cem, Günen, Hakan, and Aydın, N. Engin
- Subjects
Denim Sandblasting ,Silicosis ,Kot Kumlama ,Silikozis - Abstract
Silicosis which is one of the oldest known occupational diseases is characterized by an irreversible and progressive fibrotic reaction occuring in the lungs caused by inhaling crystalline silica dust. Effective treatment for silicosis is not available. Recently, denim sandblasting especially being made in uncontrolled small-scale workplace in primitive conditions has been a striking occupation leading to silicosis . Twenty and 28 years old male patients who work in denim sandblasting for 3 years were admitted to our clinics with complaints of dyspnea and loss of weight. Chest X ray and thorax computerized tomography revealed bilateral diffuse reticulonodular and nodular opacities which were prominent in the upper and middle zones and peripheric area of pulmonary parenchyma. Restrictive disorder was observed at their pulmonary function tests. Silicosis was diagnosed by performing transbronchial biopsy in one case. Because of the similarity of complaints, radiological findings and occupational history with the former patient, no other further and invasive procedure was performed and the other patient was also diagnosed as silicosis. In developing countries in which the labor force is very cheap, silicosis becomes a public health problem in denim sandblasters and can be prevented with improvement of working conditions. We believe that further precaution must be taken to stop darkened lives while jeans is bleaching. Key words: Denim Sandblasting; Silicosis., Bilinen en eski meslek hastalıklarından biri olan silikozis, solunabilir büyüklükteki silika kristallerinin akciğer dokusunda geri dönüşümsüz ve ilerleyici bir fibrotik reaksiyon oluşturması ile karakterize tedavisi olmayan bir hastalıktır. Son yıllarda özellikle küçük ve denetimsiz atölyelerde uygunsuz koşullarda yapılan kot kumlama işi hastalığın gelişiminde farklı bir işkolu haline gelmiştir. 3 yıldır kot kumlama işinde çalışan 20 ve 28 yaşlarında iki erkek hasta, nefes darlığı ve kilo kaybı şikayetleri ile kliniğimize başvurdu. Posteroanterior akciğer grafilerinde ve toraks bilgisayarlı tomografilerinde özellikle her iki üst ve orta zonlarda ve periferik bölgelerde yoğun yerleşimli, yaygın retikülonodüler ve nodüler opasiteler izlendi. Solunum fonksiyon testlerinde restriktif tipte ventilasyon bozukluğu saptandı. Birinci olgumuza transbronşiyal biyopsi ile silikozis tanısı kondu. İkinci olgu ise ilki ile benzer yakınmaları, radyolojik bulguları ve mesleksel maruziyet öyküsü nedeniyle ileri girişimsel inceleme yapılmadan tanı aldı. İş gücünün ucuz olduğu gelişmekte olan ülkelerde kot kumlama işinde çalışanlarda bir toplum sağlığı sorunu haline gelen silikozis çalışma şartlarının düzeltilmesi ile önlenebilir. Kotlar beyazlarken kararan hayatlara son vermek için daha fazla önlem alınması gerektiği inancındayız. Anahtar kelimeler: Kot Kumlama; Silikozis.
- Published
- 2015
19. KOAH LI HASTALARDA YAVAŞ SALINIMLI TEOFİLİN DOZU VE SERUM TEOFİLİN DÜZEYİ İLİŞKİSİ+
- Author
-
GÜNEN, Hakan and KIZKIN, Özkan
- Abstract
Debates over the utilization of theophylline that has been commonly used in the treatment of bronchial asthma and COPD, in what dosage and in which group of patients, have still been continuing, because of the pharmacodynamic properties, narrow theurepeutic range and toxic effects in high doses. In this prospective study, 41 COPD patients not utilising any systemic drug, without any additional disease and with normal hepatic enzymes who consecutively applied to our clinic were evaluated. Patients using slow release theophylline for at least 10 days were divided into 2 groups; Group I (n=20) using 400 mg/day theophylline and Group II (n=21) using 600 mg/day theophylline. Serum thophylline concentrations were measured 4 hours after the morning dose. There was no difference between the groups regarding mean age and body weight (p>0.05). Mean serum theophylline concentration was 7.07±2.61 pg/ml for Group I and 12.27±3.70 pg/ml for Group II (p, Bronşiyal astım ve KOAH tedavisinde yaygın olarak kullanılan teofilinin hangi hasta grubunda ne dozda kullanılacağı ile ilgili tartışmalar ilacın farmakodinamik özellikleri, dar törapetik sınırı ve yüksek dozdaki toksik etkilerinden dolayı halen devam etmektedir. Prospektif olarak planladığımız bu çalışmada, polikliniğimize ardışık olarak başvuran KOAH tanılı, sistemik Haç kullanmayan, ilave hastalığı olmayan ve karaciğer enzimleri normal 41 hasta değerlendirildi. En az 10 gündür uzun etkili teofilini 400 mg/gün kullanan hastalar Grup 1 (n=20) ve 600 mg/gün kullananlar Grup 2 (n=21) olarak sınıflandırıldılar. Serum teofilin düzeylerine (STD) sabah dozundan 4 saat sonra bakıldı. Gruplar arasında, hastaların yaş ortalamaları ve vücut ağırlıkları açısından anlamlı fark yoktu (p>0.05). Grup 1'deki hastaların STD 7.07±2.61 pg/ml iken, Grup 2'deki hastalar için aynı değer 12.27±3.70 pg/ml olarak bulundu (p
- Published
- 2015
20. Yatan Hastalarda Tromboemboli Profilaksinin Klinik Önemi
- Author
-
KIZKIN, Özkan, HACIEVLİYAGİL, Süleyman Savaş, and GÜNEN, Hakan
- Subjects
Derin ven trombozu,Pulmoner emboli,Profilaksi ,Deep vein thrombosis,Pulmonary emboli,Prophylaxis - Abstract
Objective: Although, there are methods recommended with consensus all over the world for the prophylaxis of deep venous thrombosis (DVT) and pulmonary embolus (PE), these principles of prophylaxis may be neglected in clinical practice. Materials and Methods: This study was performed to investigate the neglected prophylaxis in patients who were transferred to our clinics after the development of PE at the hospital and in floor patients with risk factors. Patients, who were hospitalized for other reasons, developed PE, and were risky for VTE were included in the study. Charts of the patients with PE (n=21) were reviewed retrospectively, and those of the patients with risk factors for VTE (n=74) were reviewed prospectively. Results: Sixteen patients with PE were female and 5 were male. Their mean age was 44,2±14,4 years. Although they have been hospitalized for 12,6±10,7 days and their mean risk factor was 2,3 (1-4), none of them were on prophylaxis. Most frequent risk factors were operation (27,1%), elderliness (25%) and trauma (10,4%). Of the 74 patients with one or more risk factors for VTE, 43 were in surgery department, 7 were in internal medicine floor and 17 were in the intensive care unit. Their mean duration of hospitalization, mean age and mean risk factor number were 15,2±8,9 days, 48,7±18,1 years and 2,7 (1-6) risk factors respectively. Only 17 of them (23%) were on prophylaxis for VTE. Most common administration of prophylaxis was noted in intensive care clinics (52,9%) whose mean risk factor was highest (2,9%), and the least prophylaxis was noted in obstetric and gynecology clinics (7,1%). Conclusion: Although PE is an important reason for the in-hospital mortality, prophylaxis for VTE has not been administered sufficiently. We think that, in case of sufficient administration of prophylaxis especially for patients with risk factors, development of VTE and/or PE incidence and their attributable morbidity and mortality will decrease. Key words: Deep vein thrombosis, Pulmonary emboli, Prophylaxis., Amaç: Derin ven trombozu (DVT) ve pulmoner emboli (PE) profilaksisinde tüm dünyada kabul gören ve rutin kullanıma girmiş yöntemler olmasına rağmen, klinik uygulamalarda mevcut proflaksi prensipleri ihmal edilebilmektedir. Bu çalışma; hastanede yatarken PE gelişerek servisimize devredilen ve venöz tromboemboli (VTE) için risk faktörü taşıyan yatan hastalarda, ihmal edilmiş profilaksiyi araştırmak için yapılmıştır. Materyal ve Metod: Başka nedenlerle yatırılan; takibi sırasında PE tanısı almış hastalar ve hastanemizde VTE için risk grubundaki hastalar çalışmaya dahil edildi. Dosyalarına ulaşılabilen PE tanılı 21 hastanın dosyası retrospektif; VTE için risk grubundaki 74 hastanın dosyası prospektif olarak incelendi. Bulgular: PE tanısı alan hastaların 16'sı kadın, 5'i erkekti ve yaş ortalaması 44,2±14,4 yıl bulundu. Tanı öncesinde ortalama 12,6±10,7 gündür hastanede yattıkları, PE için ortalama 2,3 (1-4) riske sahip oldukları, buna rağmen hiçbirisinin profilaksi almadığı tespit edildi. En sık görülen risk faktörleri sırasıyla; operasyon (%27,1), ileri yaş (%25) ve travmaydı (%10,4). VTE için bir veya daha fazla risk taşıyan 74 hastanın; 43'ü cerrahi, 7'si dahili kliniklerde ve 17'si yoğun bakım ünitesinde ortalama 15,2±8,9 gündür yatıyorlardı. Yaş ortalaması 48,7±18,1 yıl olup, ortalama 2,7 (1-6) riske sahip olmalarına rağmen, yalnızca 17 olgu (%23) VTE için profilaksi alıyordu. En sık profilaksi, risk faktörlerinin en fazla olduğu (ortalama 2,9) yoğun bakım ünitelerinde (%52,9), en az profilaksi ise kadın-doğum kliniğinde (% 7,1) kullanılmaktaydı. Sonuç: PE, hastane ölümlerinin önemli bir kısmını oluşturmasına rağmen hastanemizde VTE'nin profilaksisine gereken önem verilmemektedir. Özellikle risk grubundaki hastalara profilaksi uygulanması halinde, hastanede gelişen VTE insidansını ve buna bağlı morbidite ve mortalitenin azalacağını düşünüyoruz. Anahtar kelimeler: Derin ven trombozu, Pulmoner emboli, Profilaksi
- Published
- 2015
21. Swyer-James (Macleod) Sendromu: Bir Olgu Nedeniyle
- Author
-
Gülbaş, Gazi, Mutlu, Levent Cem, Hacıevliyagil, Süleyman Savaş, Yumrutepe, Tuncay, and Günen, Hakan
- Subjects
Akciğer,Hiperlüsent,Swyer-James (Macleod) Sendromu - Abstract
Fourty two-year old male patient applied wih complaints of cough and dispnea. As there was evident hyperinflation in left lung on Posterior-Anterior (PA) chest roentgenogram, the patients was diagnosed to have Swyer-James (MacLeod) syndrome using the findings on ventilation/ perfusion scintigraphy, computerised thorax tomography and magnetic resonans (MR) angiography of thorax. We presented the case with the latest literature update as it is a rarely encountered syndrome. Key words: Lung, Hyperlucenct, Swyer-James ( Macleod ) Syndrome, 42 yaşında erkek hasta nefes darlığı ve öksürük şikayetleri ile başvurdu. Posterior Anterior (PA) akciğer grafisinde sol akciğerde belirgin havalanma artışı mevcut olan hastaya, ventilasyon- perfüzyon sintigrafisi, bilgisayarlı toraks tomografisi, toraks manyetik rezonans (MR) anjiyografi bulguları ile ‘Swyer-James (MacLeod) sendromu' tanısı konuldu. Nadir görülen bir sendrom olması nedeniyle son literatür bilgileri ışığında sunmayı uygun gördük. Anahtar Kelime:Akciğer, Hiperlüsent, Swyer-James (Macleod) Sendromu
- Published
- 2015
22. Akciğer Kanseri île îlişkili Paraneoplastik Pemfigus : Olgu Sunumu
- Author
-
ÖZCAN, Hamdi, GÜNEN, Hakan, TÜRKER, Gamze, and DOĞAN, Gürsoy
- Subjects
Akciğer Kanseri,Paraneoplastik Pemfigus,Tanı ,Lung Cancer,Paraneoplastic Pemphigus,Diagnosis - Abstract
Background: Many dermatologic lesions secondary to lung cancers may be encountered as paraneoplastic syndromes. But by now, very few case reports have been published showing the co -existence of lung cancer and paraneoplastic pemphigus. Case: A 73-year-old male patient, on follow up by the dermatology clinics with the diagnosis of pemphigus erythematosis for 1.5 month, was admitted to our pneumatology clinic with the chief complaint of cough, hemoptysis and weight loss. In posteroanterior chest roentgenogram and computerised thorax tomography examinations of the patient, a right sided mass with mediastinal invasion was detected. Pathologic examination of the bronchoscopic forceps biopsies from the main carina was reported as undifferentiated large cell carcinoma. Thereafter, by detailed re-examination of the dermatologic lesions with biopsies, these lesions were considered as paraneoplastic pemphigus secondary to lung cancer. Conclusion: We presented the case because of its extreme rarity and to draw attention to the fact that many dermatologic lesions, even though atypical, may be early indicators of lung cancers. Key words: Lung Cancer, Paraneoplastic Pemphigus, Diagnosis, Giriş: Bir çok deri lezyonu akciğer kanserlerine sekonder paraneoplastik sendrom olarak görülebilir. Fakat şimdiye kadar, akciğer kanserleri ile paraneoplastik pemfigus birlikteliğini gösteren çok az sayıda olgu yayınlanmıştır. Olgu: Birbuçuk aydır dermatoloji polikliniğinde pemfigus eritematozus tanısı ile takip edilen 73 yaşındaki erkek hasta öksürük, hemoptizi ve kilo kaybı şikayetleri ile göğüs hastalıkları polikliniğimize başvurdu. Hastanın posteroanterior akciğer grafisi ve bilgisayarlı to raks tomografisinde sağ akciğer yerleşimli mediastene invaze kitle saptandı. Ana karinadan alınan bronkoskopik forseps biyopsilerinin patolojik incelemesi, indiferansiye büyük hücreli karsinomu ortaya çıkardı. Daha sonra, dermatolojik lezyonlardan biyopsil er alınarak yapılan detaylı tekrar incelenmesinde, bu lezyonlar akciğer kanserine bağlı paraneoplastik pemfigus olarak değerlendirildi. Sonuç: Biz, olguyu çok nadir görülmesi ve atipik de olsa, birçok deri lezyonunun akciğer kanserlerinin erken bir göstergesi olabileceği gerçeğine dikkati çekmek amacıyla sunmayı uygun bulduk. Anahtar kelimeler: Akciğer Kanseri, Paraneoplastik Pemfigus, Tanı
- Published
- 2015
23. Akut Solunum Yetmezliği Olan KOAH Hastalarında İlave Oksijen Tedavisinin Hipoksi Ve Hiperkapniye Etkisi
- Author
-
Mutlu, Levent Cem, Hacıevliyagil, Süleyman Savaş, Günen, Hakan, and Kızkın, Özkan
- Subjects
COPD,Supplemental oxygen therapy,Hypoxemia,Hypercapnia ,KOAH,İlave oksijen tedavisi,Hipoksi,Hiperkapni - Abstract
Background: Hypoxemia and hypercapnia are frequently encountered in chronic obstructive pulmonary disease (COPD) patients with acute attack. Objectives: To investigate the effect of 2 L/min oxygen given with nasal cannula on hypoxemia and hypercapnia in COPD patients with respiratory failure. Methods: Twenty-six type I (Group I) and 36 type II (Group II) respiratory failure patients were included in the study. The patients' initial clinical and laboratory findings were obtained. Spirometric examination and arterial blood gas (ABG) analysis were repeated after the administration of optimal medical therapy including 2 L/min oxygen given with nasal cannula. The patients whose PaCO2 values increased more than 10 mmHg with the treatment were also grouped as Group III, and their comparison was made with the rest of the patients (Group IV). Results: Among the initial laboratory parameters; PaO2 was lower in Group II (p0.05). In Group III, longer disease duration and higher rate of cor pulmonale were found to be statistically significant when compared with Group IV (p, Giriş: Kronik obstruktif akciğer hastalığı (KOAH) akut atağında; hipoksemi ve hiperkapniye sıklıkla rastlanılmaktadır. Amaç: Solunum yetmezliği olan KOAH hastalarında, nazal kanül ile verilen 2 L/dk oksijenin, hipoksemi ve hiperkapniye etkisini araştırmaktır. Gereç ve Yöntem: Yirmi altı tip I (Grup I) ve 36 tip II (Grup II) solunum yetmezlikli hasta çalışmaya alındı. Hastaların başvuru klinik ve laboratuar bulguları kaydedildi. Hastalar tam tıbbi tedavi yanısıra nazal kanülle 2 L/dk ilave oksijen aldıktan sonra, solunum fonksiyon testleri ve arter kan gazı (AKG) ölçümleri tekrar edildi. Tedavi ile PaCO2 değerleri 10 mmHg'dan daha fazla yükselenler Grup III'ü oluşturdu ve geri kalan hastalarla (Grup 4) karşılaştırılmaları yapıldı. Bulgular: Başlangıç laboratuvar parametrelerinden; PaO2 Grup II'de daha düşüktü. Her iki grupta tedavi sonrası saptanan PaO2 değerlerindeki artış istatistiksel olarak anlamlıydı (p0.05). Grup 3'de Grup 4'e göre hastalık süresinin daha uzun olması ve kor pulmonale'nin daha fazla olması istatistiksel olarak anlamlı saptandı (p
- Published
- 2015
24. BİR OLGU NEDENİYLE WEGENER GRANÜLAMATOZİSİ
- Author
-
KIZKIN, Özkan, TÜRKER, Gamze, GÜNEN, Hakan, AVCI, Hilala, MİMAN, Murat Cem, and AYDIN, Erdinç
- Subjects
Wegener's granulomatosis,orbital Involvement,tuberculosis ,Wegener granülomatoz'ıs'ı,orbita tutulumu,tüberküloz - Abstract
Wegener's granulomatosis is the most common vasculitis involving the lungs. Since It causes nodular and cavitary lesions in the lung, the differential diagnosis includes various diseases including primarily tuberculosis and malignancies. We presented this case because he was followed up for a long time with the diagnosis of chronic sinusitis, presenting with orbital involvement and simulating tuberculosis, and the time from the initiation of symptoms to the diagnosis was four years Key words: Wegener's granulomatosis, orbital Involvement, tuberculosis, Wegener granülamatozisi akciğerleri tutan vaskuiitier arasında en yaygın olanıdır. Akciğerde oluşturduğu nodüier ve kaviter lezyonlar nedeniyle, başta tüberküloz ve malignlteler olmak üzere pek çok hastalığın ayırıcı tanısına girer. Kronik sinüzit tanısıyla uzun süre takip edilen, akciğerdeki kaviter lezyonlardan ötürü tüberküloz tedavisi alan hasta; orbita tutulumu olması, tüberkülozu taklit etmesi ve semptomların başlangıcı He teşhis arasında geçen sürenin 4 yıl olması nedenleriyle sunulmaktadır. Anahtar kelimeler: Wegener granülomatoz'ıs'ı, orbita tutulumu, tüberküloz
- Published
- 2015
25. YAŞ VE HASTALIK SÜRESİ ASTIMLI HASTALARDA TEDAVİYE CEVABI ETKİLER Mİ ?
- Author
-
GÜNEN, Hakan
- Subjects
Astım,tedavi cevabı,yaş,hastalık süresi ,Asthma,treatment response,age,disease duration - Abstract
Objective: We prospectiveiy investigated the correlation between response to the treatment and age and disease duration in asthmatic patients with predicted FEVi of 50-80 %, according to changes in FEV1 parameter. Material and Methods: Eighty patients completed the study. All patients regularly utilized 8002000 mcg/day inhaled Budesonide and 100 mcg/day inhaled Sa/meterol for three months. The patients' response rate to the treatment was calculated by comparing their initial and final FEV1 values. The statistical correlation between these response rates and patients' age [18-40 years of age (n:25); 41-60 years of age (n:37) and older than 60 years of age (n:18)] and disease duration [1-5 years (n:20); 6-10 years (n:18); 11-15 years (n:15); 16-20 years (n:14); longer than 20 years (n:13)] was investigated in a stepwise manner. Results: By evaluation of final FEV1 values and response rates to the treatment found by the difference between initial and final FEV1 values, no difference could be detected between 18-40 years of age and 41-60 years of age groups (p>0.05), but the values in both groups were found to be better than the older than 60 years of age group (p0.05); in comparison of the final FEV1 values, the first group was found to be better than the fifth group (p, Amaç: Çalışmamızda FEVı değerleri öngörülenin %50-80'i arasında olan astımlı hastaların FEVı parametresinde meydana gelen değişikliğe göre tedaviye verdikleri cevabın yaş ve hastalık süreleri He olan ilişkisini prospektif olarak araştırdık. Materyal-Metot: Çalışmayı 80 hasta tamamladı. Tüm hastalar üç ay boyunca düzenli olarak inhale 800-2000 mcg/gün Budesonide ve 100mcg/gün Saimeterol kullandılar. Hastaların çalışmanın başındaki ve sonundaki FEVı değerlerinin karşılaştırılmasıyla astım tedavisinden ne oranda fayda gördükleri hesaplandı. Daha sonra bu düzelme oranları ile basamaklı olarak hastaların yaşı [18-40 yaş (n:25); 41-60 yaş (n:37) ve 60 yaşın üzerindekiler (n:18)] ve hastalık süreleri [1-5 yıl (n:20); 610 yıl (n:18); 11-15 yıl (n:15); 16-20 yıl (n:14); 20 yılın üstü (n:13)] arasındaki istatistiki ilişki araştırıldı. Bulgular: Yaşa göre ayrılan üç grubun son FEV1 değerleri karşılaştırmalarında ve ilk ve son FEV1 değerleri arasındaki farkın bulunmasıyla hesaplanan tedaviden fayda görme oranları bakımından 1840 ve 41-60 yaş grupları arasında fark saptanmazken (p>0.05), her iki gruptaki değerler de 60 yaş üstü gruptan daha iyi bulundu (p0.05); son FEV11erinin karşılaştırılmasında birinci grup, beşinci gruba göre daha iyi bulundu (p
- Published
- 2015
26. Pulmoner Tromboembolide Genetik Risk Faktörleri (Beş Olgu Nedeniyle)
- Author
-
KIZKIN, Özkan, HACIEVLİYAGİL, S. Savaş, MUTLU, Levent Cem, GÜNEN, Hakan, and YILDIRIM, Zeki
- Abstract
Pulmonary thromboembolus is a disease with high mortality and morbidity. In addition to well known and frequent risk factors, there are some rare congenital predisposing factors. In five of 43 patients (11.6%) diagnosed as pulmonary embolus between 1998 and 2001 in our clinic we detected a genetic risk factor for venous thromboemboli. Except one patient, there were no formerly known genetic risk factor. Due to our results, it can be proposed that the genetical predisposition should be searched in patients who developed venous thromboemboli without any known risk factor. We discussed 3 patients with antiphospholipid syndrome, one patient with protein C deficiency and one patient with protein S deficiency and activated protein C resistance (APC-R), in total 5 cases, with regard to current literature. Keywords: Antiphospholipid Syndrome, Protein C Deficency, Protein S Deficency, Activated C Resistance, Pulmonary Thromboemboli, Pulmoner tromboemboli mortalite ve morbiditesi yüksek bir hastalıktır. Hastalık için bilinen ve sık görülen risk faktörlerinin yanı sıra, kongenital predispozisyon yaratan nadir durumlar da vardır. Kliniğimizde 1998-2001 yıllarında takip edilen pulmoner tromboembolili 43 hastanın beşinde (%11.6) venöz tromboemboli için genetik risk faktörü saptadık. Hastaların biri dışında hiçbirisinde daha önceden bilinen bir genetik risk faktörü yoktu. Bu yüzden; bilinen bir risk faktörü olmadığı halde, venöz tromboemboli gelişen hastalarda genetik yatkınlık sebepleri araştırılmalıdır. Biz antifosfolipid sendromlu üç, protein C eksikliği olan bir ve protein S eksikliği- aktive protein C rezistanslı (APC-R) bir olguda gelişen pulmoner tromboembolili toplam beş olguyu, ilgili literatür eşliğinde tartıştık. Anahtar kelimeler: Antifosfolipid Sendromu, Protein C Eksikliği, Protein S Eksikliği, Aktive Protein C Rezistansı, Pulmoner Tromboemboli.
- Published
- 2015
27. Bir Olgu Nedeniyle Poland Sendromu
- Author
-
Hacıevliyagil, Süleyman Savaş, Gülbaş, Gazi, Mutlu, Levent Cem, Yetkin, Özkan, Ulutaş, Hakkı, and Günen, Hakan
- Subjects
Poland sendromu,Pektoralis major kası,Tek taraflı saydam akciğer. Poland Syndrome ,Poland syndrome,Absence of pectoralis major,Unilateral hyperlusensy. Poland sendromu tek taraflı pektoralis major kasının yokluğu ile karakterize konjenital - Abstract
Poland syndrome is a rarely encountered genetical disorder that is characterized with unilateral absence of pectoralis major muscle. Upper extremity deformities and anomalies in the breast, nipple and hand may accompany the syndrome. It is generally right sided and is more frequent in males. A 36 year-old male patient's PA chest X-ray who was admitted with the complaint of haemoptysis, showed rightsided hyperlucency. His chest computed tomography demonstrated Poland syndrome. This patient was presented as case report because of rarity of Poland syndrome. Key words: Poland syndrome, Absence of pectoralis major, Unilateral hyperlusensy. Poland sendromu tek taraflı pektoralis major kasının yokluğu ile karakterize konjenital, Poland sendromu pektoralis major kasının tek taraflı yokluğu ile karakterize konjenital bir sendromdur. Bu sendroma meme, el ve diğer organ anomalileri de eşlik edebilir. Genellikle sağ tarafı tutar ve erkeklerde daha sıktır. Otuzaltı yaşında hemoptizi ile başvuran erkek hastanın çekilen akciğer grafisinde sağ hemitoraksta saydamlık artışı saptandı. Bu nedenle çekilen toraks bilgisayarlı tomografisinde Poland sendromu saptandı. Bu olgu az görüldüğü ve radyolojik özellikleri nedeniyle sunulmuştur. Anahtar kelimeler: Poland sendromu, Pektoralis major kası, Tek taraflı saydam akciğer. Poland Syndrome
- Published
- 2015
28. Sülfasalazin'e Bağlı Gelişen Eozinofilik Pnömoni.
- Author
-
Eroğlu, Selma Aydoğan, Günen, Hakan, Yakar, Halil İbrahim, and Duman, Dildar
- Abstract
Eosinophilic lung disease encompasses a large group of diseases caused by increased blood or tissue eosinophilia. Eosinophilic pneumonia due to prescription drug use is a condition in which pulmonary infiltrates with blood or tissue eosinophilia are seen. A 28-year-old female patient admitted to the outpatient clinic with complaints of fever, chills, and a cough of 3 weeks duration. She had been taking antibiotics for 15 days with a diagnosis of pneumonia, but her complaints did not change. Her history revealed the use of sulfasalazine due to sacroiliitis. A rheumatology examination detected no other rheumatic disease. A posteroanterior chest Xray showed bilateral peripheral opacities. A peripheral blood count revealed leukocytosis and eosinophilia. A thoracic computed tomography image revealed bilateral peripheral ground glass opacities, septal thickening, and reticular densities. Based on the findings of eosinophilia, no response to antibiotics, and no other systemic disease, it was considered that the condition might be related to the use of sulfasalazine. Sulfasalazine was discontinued and prednisolone therapy was started. The patient's symptoms improved dramatically, and the abnormal blood values returned to normal. Radiologically, complete regression was observed. This was a case of eosinophilic pneumonia due to the use of sulfasalazine. It is important that drug history is handled carefully in every pulmonary evaluation. [ABSTRACT FROM AUTHOR]
- Published
- 2018
- Full Text
- View/download PDF
29. RE: Lymphocytes and Eosinophils Associated with the COVID-19 Severity.
- Author
-
Duman, Dildar, Karakurt, Zuhal, Koçak, Nagihan Durmuş, Adıgüzel, Nalan, Yıldız, Tekin, Güngör, Gökay, Takır, Huriye Berk, Tepetam, Fatma Merve, and Günen, Hakan
- Subjects
EOSINOPHILS ,BIOMARKERS ,COVID-19 ,LYMPHOCYTES ,BLOOD cell count - Published
- 2023
- Full Text
- View/download PDF
30. Waterpipe tobacco smoking
- Author
-
GÜNEN, Hakan, primary, TARRAF, Hisham, additional, NEMATI, Abbas, additional, AL GHOBAIN, Mohammed, additional, AL MUTAIRI, Sana, additional, and AOUN BACHA, Zeina, additional
- Published
- 2016
- Full Text
- View/download PDF
31. A case of Takayasu's arteritis with endobronchial involvement
- Author
-
ÇOBAN AĞCA, Meltem, primary, DUMAN, Dildar, additional, TEPETAM, Fatma Merve, additional, TOKGÖZ, Fatma, additional, ŞEN, Ayçim, additional, GÜNEN, Hakan, additional, and YARKIN, Tülay, additional
- Published
- 2015
- Full Text
- View/download PDF
32. Astım-KOAH overlap Sendromu
- Author
-
ŞEN, Elif, primary, OĞUZÜLGEN, Kıvılcım, additional, BAVBEK, Sevim, additional, GÜNEN, Hakan, additional, KIYAN, Esen, additional, TÜRKTAŞ, Haluk, additional, YORGANCIOĞLU, Arzu, additional, POLATLI, Mehmet, additional, YILDIZ, Füsun, additional, ÇELİK, Gülfem, additional, DEMİR, Tunçalp, additional, GEMİCİOĞLU, Bilun, additional, MUNGAN, Dilşad, additional, SARYAL, Sevgi, additional, SAYINER, Abdullah, additional, and YILDIRIM, Nurhayat, additional
- Published
- 2015
- Full Text
- View/download PDF
33. Kronik obstrüktif akciğer hastalığında genetik risk faktörleri
- Author
-
Mutlu, Levent Cem, Gülbaş, Gazi, and Günen, Hakan
- Subjects
Solunum Sistemi - Abstract
Kronik obstrüktif akciğer hastalığı (KOAH) oluşumunda genetik faktörlerin rolünün önemli olduğu fikri genel olarak kabul edilmektedir. Bununla birlikte, yarım asırdan uzun süredir yapılan birçok çalışmadan ?-1 antitripsin eksikliğinin tek başına KOAHa yol açabileceği bilgisi dışında kesin bir sonuç elde edilememiştir. Elimizdeki veriler ışığında, birçok gen bozuklukları arasındaki etkileşimlerin üstüne eklenen sigara dumanı gibi çevresel faktörlerin KOAH oluşumdan sorumlu olduğu söylenebilir. Şüphesiz gelecekte de KOAH oluşumunda genetik risk faktörleri, üzerinde en fazla çalışılan konulardan biri olmaya devam edecektir. The role of genetic factors in development of chronic obstructive pulmonary disease (COPD) is accepted in general. However, other than α-1 antitrypsin deficiency which alone can lead to COPD, the studies performed longer than half a century did not yield any certain result on the genetics of COPD. Regarding the data available, it can be said that addition of environmental factors like cigarette smoking on interrelations between genetic abnormalities are responsible for COPD development. No doubt that the role of genetics on COPD development will continue to be one of the important research issues in future too.
- Published
- 2012
34. Kot kumlamaya bağlı olarak gelişen iki silikozis olgusu
- Author
-
Ermiş, Hilal, Gülbaş, Gazi, Yumrutepe, Tuncay, İn, Erdal, Mutlu, Levent Cem, Günen, Hakan, and Aydın, N. Engin
- Subjects
Genel ve Dahili Tıp - Abstract
Bilinen en eski meslek hastalıklarından biri olan silikozis, solunabilir büyüklükteki silika kristallerinin akciğer dokusunda geri dönüşümsüz ve ilerleyici bir fibrotik reaksiyon oluşturması ile karakterize tedavisi olmayan bir hastalıktır. Son yıllarda özellikle küçük ve denetimsiz atölyelerde uygunsuz koşullarda yapılan kot kumlama işi hastalığın gelişiminde farklı bir işkolu haline gelmiştir. 3 yıldır kot kumlama işinde çalışan 20 ve 28 yaşlarında iki erkek hasta, nefes darlığı ve kilo kaybı şikayetleri ile kliniğimize başvurdu. Posteroanterior akciğer grafilerinde ve toraks bilgisayarlı tomografilerinde özellikle her iki üst ve orta zonlarda ve periferik bölgelerde yoğun yerleşimli, yaygın retikülonodüler ve nodüler opasiteler izlendi. Solunum fonksiyon testlerinde restriktif tipte ventilasyon bozukluğu saptandı. Birinci olgumuza transbronşiyal biyopsi ile silikozis tanısı kondu. İkinci olgu ise ilki ile benzer yakınmaları, radyolojik bulguları ve mesleksel maruziyet öyküsü nedeniyle ileri girişimsel inceleme yapılmadan tanı aldı. İş gücünün ucuz olduğu gelişmekte olan ülkelerde kot kumlama işinde çalışanlarda bir toplum sağlığı sorunu haline gelen silikozis çalışma şartlarının düzeltilmesi ile önlenebilir. Kotlar beyazlarken kararan hayatlara son vermek için daha fazla önlem alınması gerektiği inancındayız. Silicosis which is one of the oldest known occupational diseases is characterized by an irreversible and progressive fibrotic reaction occuring in the lungs caused by inhaling crystalline silica dust. Effective treatment for silicosis is not available. Recently, denim sandblasting especially being made in uncontrolled small-scale workplace in primitive conditions has been a striking occupation leading to silicosis . Twenty and 28 years old male patients who work in denim sandblasting for 3 years were admitted to our clinics with complaints of dyspnea and loss of weight. Chest X ray and thorax computerized tomography revealed bilateral diffuse reticulonodular and nodular opacities which were prominent in the upper and middle zones and peripheric area of pulmonary parenchyma. Restrictive disorder was observed at their pulmonary function tests. Silicosis was diagnosed by performing transbronchial biopsy in one case. Because of the similarity of complaints, radiological findings and occupational history with the former patient, no other further and invasive procedure was performed and the other patient was also diagnosed as silicosis. In developing countries in which the labor force is very cheap, silicosis becomes a public health problem in denim sandblasters and can be prevented with improvement of working conditions. We believe that further precaution must be taken to stop darkened lives while jeans is bleaching.
- Published
- 2011
35. Factors related with non-invasive ventilation success in chronic obstructive pulmonary disease
- Author
-
Tokgöz Akyil, Fatma, primary, Çoban Agca, Meltem, additional, Misirlioglu, Aysun, additional, Duman, Dildar, additional, Yarkin, Tülay, additional, and Günen, Hakan, additional
- Published
- 2015
- Full Text
- View/download PDF
36. Takayasu arteritis with endobronchial involvement
- Author
-
Çoban Agca, Meltem, primary, Duman, Dildar, additional, Tepetam, Fatma Merve, additional, Tokgöz, Fatma, additional, Sen, Ayçim, additional, Günen, Hakan, additional, and Yarkin, Tülay, additional
- Published
- 2015
- Full Text
- View/download PDF
37. Acute exacerbation in COPD and asthma
- Author
-
YILDIRIM, Nurhayat, primary, DEMİR, Tunçalp, additional, GEMİCİOĞLU, Bilun, additional, KIYAN, Esen, additional, OĞUZÜLGEN, Kıvılcım, additional, POLATLI, Mehmet, additional, SARYAL, Sevgi, additional, SAYINER, Abdullah, additional, YORGANCIOĞLU, Arzu, additional, BAVBEK, Sevim, additional, ÇELİK, Gülfem E., additional, GÜNEN, Hakan, additional, MUNGAN, Dilşad, additional, ŞEN, Elif, additional, TÜRKTAŞ, Haluk, additional, and YILDIZ, Füsun, additional
- Published
- 2015
- Full Text
- View/download PDF
38. TIME ELAPSED TILL DIAGNOSIS OF EXTRA-PULMONARY TUBERCULOSIS
- Author
-
HACIEVLİYAGİL, Süleyman Savaş, MUTLU, Levent Cem, DURAN, Mustafa, KIZKIN, Özkan, TEMİZ, Şahin, EVLİYAOĞLU, Ercüment, ARICA, Zeynep Kazgan, TÜRK, Ali Önder, ŞENOĞLU, Aydın, GÜLBAŞ, Gazi, YETKİN, Özkan, and GÜNEN, Hakan
- Subjects
Akciğer dışı tüberküloz,tüberküloz plörezi,tüberküloz lenfadenit,tanı süresi ,Extra-Pulmonary Tuberculosis,tuberculous pleuritis,tuberculous lymphadenitis,diagnosis time - Abstract
Akciğer Dışı Tüberküloz (ADT), akciğer parankimi dışında gelişen tüberküloz olgularını içermektedir. Tüberküloz hastalarında sıklıkla tanıda gecikmeler görülmektedir. Bu çalışmada Malatya Verem Savaş Dispanserleri ve İnönü Üniversitesi Tıp Fakültesine başvuran ADT hastalarının özellikleri, dağılımları ve tanı konulma süreleri incelendi. Çalışmaya 150 ADT hastası alındı. Tüberküloz plörezi (n=58) ve tüberküloz lenfadenit (n=45) en çok saptanan ADT tipleriydi. ADT hastalarının yaş ortalaması 37.3±15.7 yıl olarak saptandı. Hastaların 83'ü (%55.3) kadın, 67'si (%44.7) erkekti. Tüberküloz plörezi erkeklerde (32/26), tüberküloz lenfadenit kadınlarda (33/12) daha sık gözlendi. Hastaların şikayetlerinin başlangıcı ile ADT tanısı konulması arasındaki süre ortalama 102.7±141.0 gün olup, ortalama tanı süreleri tüberküloz lenfadenit için 128.6±120.7 gün, tüberküloz plörezi için 56.2±45.7 gün olarak saptandı. En kısa tanı süresi miliyer tüberküloz ve tüberküloz menenjitin yer aldığı progresif ADT'de (29.8±33.1 gün) saptanırken, en uzun tanı süresi genitoüriner tüberkülozda (216.7±330.0 gün) bulundu. ADT'li hastaların ortalama 24.4±27.1 gün süre ile hastaneye yattıkları saptandı. Gastrointestinal tüberküloz hastaları en uzun (43.0±67.7 gün), tüberküloz lenfadenit hastaları en kısa süre (12.8±3.9 gün) hastaneye yatmışlardı. Sonuç olarak, ADT hastalarında tanı konma süresi uzun bulundu. ADT tanısının konmasında hastaların anamnezlerinde tüberküloz öyküsünün ve temasının olup olmadığının sorgulanması önemlidir. Ülkemizde tüberküloz sıklığı da göz önüne alınarak, hangi organ hastalığı olursa olsun, tanı konulamayan olgularda tüberküloza yönelik incelemelerin mutlaka yapılması gerektiğini düşünüyoruz., Extra-Pulmonary Tuberculosis (EPT) includes the tuberculosis cases other than the ones developed in the pulmonary parenchyma. The delay in the diagnosis of EPT cases is frequently encountered. In this study, time elapsed till the diagnosis, patient characteristics and their distribution were investigated in EPT patients admitted to Malatya Tuberculosis Dispensaries and Inonu University Faculty of Medicine. One-hundred and fifty EPT patients were included in the study. The most frequent EPT cases were tuberculous pleuritis (n=58) and tuberculous lymphadenitis (n=45). Mean age of the EPT patients was 37.3±15.7 years. Eighty-three of the patients (55.3%) were female, 67 of them (44.7%) were male. While tuberculous pleuritis was more frequent in male patients (32/26), tuberculous lymphadenitis was more frequent in female patients (33/12). While the average time elapsed till the diagnosis of all EPT cases since the beginning of symptoms was 102.7±141.0 days, it was 128.6±120.7 days and 56.2±45.7 days for tuberculous lymphadenitis and tuberculous pleuritis respectively. The shortest diagnosis time was for progressive tuberculosis which included miliary and meningitis tuberculosis (29.8±33.1 days), and the longest diagnosis time was for genitourinary tuberculosis (216.7±330.0 days). The mean hospitalization period for all EPT cases was 24.4±27.1 days. While the longest hospitalization period was found in patient groups with gastrointestinal tuberculosis (43.0±67.7 days respectively), the shortest hospitalization period was found in the patient group with tuberculous lymphadenitis (12.8±3.9 days). In conclusion, time elapsed to diagnose the EPT was found considerably longer than expected. Asking questions for the history of any tuberculosis and the history of close contact is important in the diagnosis of EPT. We think that, considering the high incidence of tuberculosis in our country, investigations for tuberculosis should be included in the diagnosis algorithm of the diseases involving any organ, if undiagnosed otherwise.
- Published
- 2006
39. Real life profile of asthma and chronic obstructive pulmonary disease patients in Turkey.
- Author
-
MISIRLIGİL, Zeynep, ÇIMRIN, Arif, GÜNEN, Hakan, ÖZLÜ, Tevfik, ÇİLLİ, Aykut, AKYILDIZ, Levent, BAYRAM, Hasan, GEMİCİOĞLU, Bilun, UZASLAN, Esra, ABADOĞLU, Öznur, and SUERDEM, Mecit
- Published
- 2017
- Full Text
- View/download PDF
40. Yeni bir Tanım: Kombine Pulmoner Fibrozis ve Amfizem Sendromu.
- Author
-
Duman, Dildar and Günen, Hakan
- Subjects
- *
PULMONARY fibrosis , *PULMONARY emphysema , *DYSPNEA - Abstract
Combined pulmonary fibrosis and emphysema syndrome (CPFE) is a newly defined syndrome with unique clinical findings, characterized by presence of emphysema and pulmonary fibrosis seen radiologically. Since awareness of the syndrome is insufficient, CPFE is under-recognized. Male patient presented with progressive dyspnea and history of smoking 60 packs per year. Upper lobe emphysema and lower lobe fibrosis, which are specific for CPFE syndrome, were observed in chest computed tomography scans. Forced expiratory volume 1 was relatively well preserved, but diffusing capacity of the lungs for carbon monoxide was very low, and is an important feature of the disease. Pulmonary hypertension has also been determined to be characteristic finding of the syndrome. Patient was diagnosed as CPFE syndrome based on presence of all characteristic features and case is presented with review of the literature to draw attention to this disease. [ABSTRACT FROM AUTHOR]
- Published
- 2017
- Full Text
- View/download PDF
41. Treatment of Severe Asthma: Expert Opinion
- Author
-
TÜRKTAŞ, Haluk, primary, BAVBEK, Sevim, additional, ÇELİK, Gülfem, additional, DEMİR, Tunçalp, additional, GEMİCİOĞLU, Bilun, additional, GÜNEN, Hakan, additional, KIYAN, Esen, additional, MUNGAN, Dilşad, additional, OĞUZÜLGEN, İpek Kıvılcım, additional, POLATLI, Mehmet, additional, SARYAL, Sevgi, additional, SAYINER, Abdullah, additional, ŞEN, Elif, additional, YILDIRIM, Nurhayat, additional, YILDIZ, Füsun, additional, and YORGANCIOĞLU, Arzu, additional
- Published
- 2014
- Full Text
- View/download PDF
42. Endobronşiyal tutulum gösteren Takayasu arteriti olgusu.
- Author
-
ÇOBAN AĞCA, Meltem, DUMAN, Dildar, TEPETAM, Fatma Merve, TOKGÖZ, Fatma, ŞEN, Ayçim, GÜNEN, Hakan, and YARKIN, Tülay
- Published
- 2015
- Full Text
- View/download PDF
43. KOAH ve astımda atak.
- Author
-
YILDIRIM, Nurhayat, DEMİR, Tunçalp, GEMİCİOĞLU, Bilun, KIYAN, Esen, OĞUZÜLGEN, Kıvılcım, POLATLI, Mehmet, SARYAL, Sevgi, SAYINER, Abdullah, YORGANCIOĞLU, Arzu, BAVBEK, Sevim, ÇELİK, Gülfem E., GÜNEN, Hakan, MUNGAN, Dilşad, ŞEN, Elif, TÜRKTAŞ, Haluk, and Füsun, YILDIZ
- Published
- 2015
- Full Text
- View/download PDF
44. Kronik obstrüktif akciğer hastalığında perikart sıvı birikimi mortalite öngördürücüsüdür.
- Author
-
Karabay, Can Yücel, Göl, Gökhan, Kalaycı, Arzu, Kılıçgedik, Alev, Çiftci, Merve, and Günen, Hakan
- Abstract
Copyright of Archives of the Turkish Society of Cardiology / Türk Kardiyoloji Derneği Arşivi is the property of KARE Publishing and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2015
- Full Text
- View/download PDF
45. Pulmonary Artery Agenesis: A Case Series.
- Author
-
Ağca, Meltem, Bulum, Servet, Günen, Hakan, Tokgöz, Fatma, Yarkın, Tülay, and Demir, Mine
- Subjects
PULMONARY artery diseases ,ECHOCARDIOGRAPHY ,HUMAN abnormalities ,PULMONARY stenosis ,ATRIAL septal defects - Abstract
Pulmonary artery agenesis is a rare congenital abnormality in which atresia was encountered in the short segment of the right or left pulmonary arteries. It can be isolated or associated with cardiac abnormalities such as tetralogy of Fallot, septal defects or pulmonary stenosis. The majority of cases are diagnosed in childhood whereas some cases yield no symptoms until adulthood. We evaluated retrospectively 5 pulmonary artery agenesis cases diagnosed in our clinics between 1998-2010 with respect to the literature. [ABSTRACT FROM AUTHOR]
- Published
- 2015
- Full Text
- View/download PDF
46. Ağır Astım Tedavisi: Uzman Görüşü.
- Author
-
TÜRKTAŞ, Haluk, BAVBEK, Sevim, ÇELİK, Gülfem, DEMİR, Tunçalp, GEMİCİOĞLU, Bilun, GÜNEN, Hakan, KIYAN, Esen, MUNGAN, Dilşad, OĞUZÜLGEN, İpek Kıvılcım, POLATLI, Mehmet, SARYAL, Sevgi, SAYINER, Abdullah, ŞEN, Elif, YILDIRIM, Nurhayat, YILDIZ, Füsun, and YORGANCIOĞLU, Arzu
- Published
- 2014
- Full Text
- View/download PDF
47. KOAH'da inhaler kortikosteroid/uzun etkili beta-2 agonist fiks kombinasyonunun etkileri.
- Author
-
DEMİR, Tunçalp, GÜNEN, Hakan, POLATLI, Mehmet, and YILDIRIM, Nurhayat
- Published
- 2011
- Full Text
- View/download PDF
48. The Effect of Supplemental Oxygen on Hypoxemia and Hypercapnia in COPD Patients with Acute Respiratory Failure.
- Author
-
Mutlu, Levent Cem, Hacievliyagi, Süleyman Savaş, Günen, Hakan, and Kizkin, Özkan
- Published
- 2006
49. Göğüs Hastalıkları Servisine Yatan Hastaların Hastane Yatış Maliyetlerinin Karşılaştırılması.
- Author
-
Hacıevliyagil, Suleyman Savaş, Mutlu, Levent Cem, Gülbaş, Gazi, Yetkin, Özkan, and Günen, Hakan
- Published
- 2006
50. Yatan Hastalarda Tromboemboli Profilaksinin Klinik Önemi.
- Author
-
Kizkin, Özkan, Hacievliyagil, Süleyman Savaş, and Günen, Hakan
- Published
- 2004
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.