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1. Serum‐derived bovine immunoglobulin treatment in COVID‐19 is associated with faster resolution of symptoms: A randomized pilot clinical trial.

Author

Utay, Netanya S., Güerri‐Fernández, Roberto, Gharakhanian, Shahin, Asmuth, David M., Contreras, Moises, Kunkler, Charlotte, Detzel, Christopher J., and Warner, Christopher D.

Subjects
DRUG interactions, CLINICAL trials, DISEASE management, MEDICAL supplies, ODDS ratio
Abstract

Effective treatment to prevent hospitalization and death in people with COVID‐19 exists, but people still need interventions that alleviate symptoms without drug interactions. Oral serum‐derived bovine immunoglobulins (SBI) may reduce symptoms and time‐to‐improvement in people with mild‐to‐moderate COVID‐19. In this randomized, open‐label, single‐site study, participants with mild‐to‐moderate COVID‐19 received SBI 5.0 g bis in die (BID) + Standard of Care (SOC) or SOC alone (2:1) for 2 weeks. After 2 weeks, 78.8% of hospitalized participants on SBI + SOC improved by World Health Organization (WHO) scale of ≥3 compared to 61.1% on SOC alone (odds ratio: OR = 2.4; p = 0.0663), with older participants (>57 years) showing more significant differences between the arms (OR = 6.1; p = 0.0109). Further, more participants on SBI + SOC reported absence of COVID‐19 symptoms at Week 2 (74.2%) compared to SOC alone (43.6%; OR = 3.7; p = 0.0031), most notably the absence of dyspnea on exertion (OR = 4.4; p = 0.0047), with women exhibiting the most significant eradication of all symptoms (OR = 5.8; p = 0.0080). No difference in change of IL‐6 between arms was observed. Overall, participants with mild‐to‐moderate COVID‐19 on SBI + SOC had a shorter time‐to‐recovery than on SOC alone, with a significantly higher rate of complete resolution of symptoms. Dyspnea on exertion was the symptom most significantly impacted. For people with mild‐to‐moderate COVID‐19, oral SBI could be a safe and effective intervention, devoid of drug interactions. [ABSTRACT FROM AUTHOR]

Published
2024
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2. Characteristics and predictors of death among 4035 consecutively hospitalized patients with COVID-19 in Spain

Author

Aznar Muñoz, Esther, Gil Divasson, Pedro, González Muñiz, Patricia, Muñoz Aguirre, Clara, López, Juan Carlos, Ramírez-Schacke, Margarita, Gutiérrez, Isabel, Tejerina, Francisco, Aldámiz-Echevarría, Teresa, Díez, Cristina, Fanciulli, Chiara, Pérez-Latorre, Leire, Parras, Francisco, Catalán, Pilar, García-Leoni, María E., Pérez-Tamayo, Isabel, Puente, Luis, Cedeño, Jamil, Berenguer, Juan, Díaz Menéndez, Marta, de la Calle Prieto, Fernando, Arsuaga Vicente, Marta, Trigo Esteban, Elena, Lago Núñez, Mª del Mar, de Miguel Buckley, Rosa, Cadiñaños Loidi, Julen, Busca Arenzana, Carmen, Mican, Alfredo, Mora Rillo, Marta, Ramos Ramos, Juan Carlos, Loeches Yagüe, Belén, Bernardino de la Serna, José Ignacio, García Rodríguez, Julio, Arribas López, José Ramón, Such Diaz, Ana, Álvaro Alonso, Elena, Izquierdo García, Elsa, Torres Macho, Juan, Cuevas Tascon, Guillermo, Troya García, Jesús, Mestre Gómez, Beatriz, Jiménez González de Buitrago, Eva, Fernández Jiménez, Inés, Tebar Martínez, Ana Josefa, Brañas Baztán, Fátima, Valencia de la Rosa, Jorge, Pérez Butragueño, Mario, Alvarado Blasco, Marta, Ryan, Pablo, Sepúlveda Berrocal, Mª Antonia, Yera Bergua, Carmen, Toledano Sierra, Pilar, Cano Llorente, Verónica, Zafar Iqubal-Mirza, Sadaf, Muñiz, Gema, Martín Pérez, Inmaculada, Mozas Moriñigo, Helena, Alguacil, Ana, García Butenegro, María Paz, Peláez Ballesta, Ana Isabel, Morcillo Rodríguez, Elena, Goikoetxea Agirre, Josune, Blanco Vidal, María José, Nieto Arana, Javier, del Álamo Martínez de Lagos, Mikel, Pérez Hernández, Isabel A., Pérez Zapata, Inés, Silvariño Fernández, Rafael, Ugalde Espiñeira, Jon, Asensi Álvarez, Víctor, Suárez Pérez, Lucia, Suárez Diaz, Silvia, Yllera Gutiérrez, Carmen, Boix, Vicente, Díez Martínez, Marcos, Carreres Candela, Melissa, Gómez-Ayerbe, Cristina, Sánchez-Lora, Javier, Velasco Garrido, José Luis, López-Jódar, María, Santos González, Jesús, Ruiz Aragón, Jesús, Virto Peña, Ianire, Alende Castro, Vanessa, Brea Aparicio, Ruth, Vega Molpeceres, Sonia, Pons Viñas, Estel, del Río Pérez, Oscar, Valero Rovira, Silvia, Villar-García, Judit, Gómez-Junyent, Joan, Knobel, Hernando, Cánepa, María Cecilia, Castañeda Espinosa, Silvia, Sorli Redò, Luisa, Güerri-Fernández, Roberto, Milagro Montero, María, Horcajada, Juan Pablo, García Vázquez, Elisa, Moral Escudero, Encarnación, Hernández Torres, Alicia, García Almodóvar, Esther, Sáez Barberá, Carmen, Karroud, Zineb, Hernández Quero, José, Vinuesa García, David, García Fogeda, José Luis, Peregrina, José Antonio, Novella Mena, María, Hernández Gutiérrez, Cristina, Sanz Moreno, José, Pérez Tanoira, Ramón, Sierra Rodríguez, Rodrigo, Alonso Menchén, David, Gutiérrez García, Aida, Arranz Caso, Alberto, Cuadros González, Juan, Álvarez de Mon Soto, Melchor, Díaz de Brito Fernández, Vicente Ferrer, Sanmarti Vilamala, Montserrat, Gabarrell Pascuet, Aina, Molina Morant, Daniel, España Cueto, Sergio, Cámara Fernández, Jonathan, Sabater Gil, Albert, Muñoz López, Laura, Sáez Escolano, Paula, Bejarano Tello, Esperanza, Sempere Alcocer, Marco Antonio, Álvarez Martin, Salvador, De los Santos Gil, Ignacio, García-Fraile, Lucio, Sampedro Núñez, Miguel, Barrios Blandino, Ana, Rodríguez Franco, Carlos, Useros Brañas, Daniel, Villa Martí, Almudena, Oliver Ortega, Javier, Costanza Espiño Álvarez, Alexia, Sanz Sanz, Jesús, Rexach Fumaña, María, Abascal Cambras, Ivette, Pérez Jaén, Ana del Cielo, Sala Jofre, Clara, Casas Rodríguez, Susana, Tortajada Alamilla, Cecilia, Oltra, Carmina, Masiá Canuto, Mar, Gutiérrez Rodero, Félix, Ferrer Ribera, Ana, Bea Serrano, Carlos, Pedromingo Kus, Miguel, Garcinuño, María Ángeles, Fiorante, Silvana, Pérez Pinto, Sergio, Hernández Machín, Pilar, Alastrué Violeta, Alba, Fariñas Álvarez, María Carmen, González Rico, Claudia, Arnaiz de las Revillas, Francisco, Calvo, Jorge, Gozalo, Mónica, Mora Gómez, Francisco, Milagro Beamonte, Ana, Latorre-Millán, Miriam, Rezusta López, Antonio, Martínez Sapiña, Ana, Meije, Yolanda, Duarte Borges, Alejandra, Pareja Coca, Julia, Clemente Presas, Mercedes, Losa García, Juan Emilio, Vegas Serrano, Ana, Pérez-Rodríguez, M. Teresa, Pérez González, Alexandre, Belhassen-García, Moncef, Rodríguez-Alonso, Beatriz, López-Bernus, Amparo, Carbonell, Cristina, Torres Perea, Rafael, Cantón de Seoane, Juan, Alonso, Blanca, Kamal, Sara Lidia, Cajuela, Lucia, Roa, David, Cervero, Miguel, Oreja, Alberto, Avilés, Juan Pablo, Martín, Lidia, Pelegrín Senent, Iván, Rouco Esteves Marques, Rosana, Parra Ruiz, Jorge, Ramos Sesma, Violeta, Abadia Otero, Jessica, Salillas Hernando, Juan, Torres Sánchez del Arco, Robert, Torralba González de Suso, Miguel, Serrano Martínez, Alberto, Gilaberte Reyzábal, Sergio, Pacheco Martínez-Atienza, Marina, Liébana Gómez, Mónica, Fernández Rodríguez, Sara, Varela Plaza, Álvaro, Calvo Sánchez, Henar, Martínez Martín, Patricia, González- Ruano, Patricia, Malmierca Corral, Eduardo, Rábago Lorite, Isabel, Pérez-Monte Mínguez, Beatriz, García Flores, Ángeles, Comas Casanova, Pere, Sirisi, Merce, Rojas, Richard, Díaz de Tuesta del Arco, José Luis, Figueroa Cerón, Ruth, González Sarria, Ander, Alemán Valls, Remedios, Alonso Socas, María del Mar, Sanz Peláez, Oscar, Mohamed Ramírez, Karim, Riera Jaume, Melchor, Vilchez, Helem Haydee, Albertí, Francesc, Cañabate, Ana Isabel, Moreno Cuerda, Víctor J., Álvarez Kaelis, Silvia, Álvarez Zapatero, Beatriz, García García, Alejandro, Isaba Ares, Elena, Morcate Fernández, Covadonga, Pérez Rodríguez, Andrea, Ramos Merino, Lucía, Castelo Corral, Laura, Rodríguez Mahía, María, González Bardanca, Mónica, Sánchez Vidal, Efrén, Míguez Rey, Enrique, De la Torre Lima, Javier, García de Lomas Guerrero, José Mª, Morte, Elena, Loscos, Silvia, Camón, Ana, Gómez García, Lucía, Boix Palop, Lucia, Dietl Gómez-Luengo, Beatriz, Pedrola Gorrea, Iris, Blasco Claramunt, Amparo, López Mestanza, Cristina, Fraile Villarejo, Esther, Tosco Núñez, Tomás, Aroca Ferri, María, Algado Rabasa, José Tomas, Garijo Saiz, Ana María, Amador Prous, Concepción, Baño, Jesús Rodriguez, Retamar, Pilar, Valiente, Adoración, López-Cortés, Luis E., Sojo, Jesús, Gutiérrez-Gutiérrez, Belén, Bravo-Ferrer, José, Salamanca, Elena, Palacios, Zaira R., Pérez-Palacios, Patricia, Peral, Enrique, Pérez de León, José Antonio, Sánchez-Gómez, Jesús, Marín-Barrera, Lucía, García-Jiménez, Domingo, Carratalà, Jordi, Abelenda-Alonso, Gabriela, Ardanuy, Carmen, Bergas, Alba, Cuervo, Guillermo, Domínguez, María Ángeles, Fernández-Huerta, Miguel, Gudiol, Carlota, Lorenzo-Esteller, Laia, Niubó, Jordi, Pérez-Recio, Sandra, Podzamczer, Daniel, Pujol, Miquel, Rombauts, Alexander, Trullen, Núria, Salavert Lletí, Miguel, Castro Hernández, Iván, Hernández Belmonte, Adriana, Martínez Goñi, Raquel, Navarro Vilasaró, Marta, Calzado Isbert, Sonia, Cervantes García, Manuel, Gomila Grange, Aina, Gasch Blasi, Oriol, Machado Sicilia, María Luisa, Van den Eynde Otero, Eva, Falgueras López, Luis, Navarro Sáez, María del Carmen, Martínez, Esteban, Marcos, Mª Ángeles, Mosquera, Mar, Blanco, José Luis, Laguno, Montserrat, Rojas, Jhon, González-Cordón, Ana, Inciarte, Alexy, Torres, Berta, De la Mora, Lorena, Soriano, Alex, Martínez Macias, Olalla, Pérez Doñate, Virginia, Cabello Úbeda, Alfonso, Carrasco Antón, Nerea, Álvarez Álvarez, Beatriz, Petkova Saiz, Elizabet, Górgolas Hernández-Mora, Miguel, Prieto Pérez, Laura, Carrillo Acosta, Irene, Heili Frades, Sara, Villar Álvarez, Felipe, Fernández Roblas, Ricardo, Milicua Muñoz, José María, Fernández Espinilla, Virginia, Dueñas Gutiérrez, Carlos Jesús, Hernán García, Cristina, González-Romo, Fernando, Merino Amador, Paloma, Rueda López, Alba, Martínez Jordán, Jorge, Medrano Pardo, Sara, Díaz de la Torre, Irene, Posada Franco, Yolanda, Delgado-Iribarren, Alberto, López-Contreras González, Joaquín, Pascual Alonso, Pablo, Pomar Solchaga, Virginia, Rabella García, Nuria, Benito Hernández, Natividad, Domingo Pedrol, Pere, Bonfill Cosp, Xavier, Padrós Selma, Rafael, Puig Campmany, Mireia, Mancebo Cortés, Jordi, Gurguí Ferrer, Mercè, Íñigo Pestaña, Melania, Pérez García, Alejandra, Sorní Moreno, Patricia, Izko Gartzia, Nora, Membrillo de Novales, Francisco Javier, Simón Sacristán, María, Zamora Cintas, Maribel, Martínez Martínez, Yolanda, Fernández-González, Pablo, Alcántara Nicolás, Francisco, Aguirre Vila-Cora, Alejandro, López Tizón, Elena, Ramírez-Olivencia, Germán, Estébanez Muñoz, Miriam, Sáez de Adana Arróniz, Ester, Portu Zapirain, Joseba, Gainzarain Arana, Juan Carlos, Ortiz de Zárate Ibarra, Zuriñe, Moran Rodríguez, Miguel Ángel, Canut Blasco, Andrés, Hernáez Crespo, Silvia, Balerdi Sarasola, Leire, Morales García, Cristina, Corral Saracho, Miguel, Valcarce González, Zeltia, Arenal Andrés, Noelia, Rodríguez Tarazona, Raquel Elisa, Iglesias Llorente, Laura, Loureiro Rodríguez, Beatriz, Sánchez Montalvá, Adrián, Espinosa Pereiro, Juan, Almirante, Benito, Miarons, Marta, Sellarés, Júlia, Larrosa, María, García, Sonia, Marzo, Blanca, Villamarín, Miguel, Fernández, Nuria, Pérez-Jorge Peremarch, Conchita, Resino Foz, Elena, Espigares Correa, Andrea, Álvarez de Espejo Montiel, Teresa, Navas Clemente, Iván, Quijano Contreras, María Isabel, Nieto Fernández del Campo, Luis Alberto, Jiménez Álvarez, Guillermo, Guillamón Sánchez, Mercedes, García García, Josefina, Muñoz Hornero, Constanza, Mariño Callejo, Ana, Valcarce Pardeiro, Nieves, Smithson Amat, Alex, Chico Chumillas, Cristina, Sánchez Serrano, Adriana, García Villalba, Eva Pilar, Jiménez Martínez, Isabel, Estrada Fernández, Guillermo, Lorén Vargas, María, Parra Arribas, Nuria, Martínez Cilleros, Carmen, Villasante de la Puente, Aránzazu, García Delange, Teresa, Ruiz Rodríguez, María José, Robledo del Prado, Marta, Abad Almendro, Juan Carlos, Muñoz del Rey, José Román, Jiménez Álvaro, Montaña, Coy Coy, Javier, Poquet Catala, Inmaculada, Santos Peña, Marta, Naranjo Velasco, Virginia, Manso Gómez, Tamara, Quilez Ágreda, Delia, Barbeito Castiñeiras, Gema, Domínguez Santalla, María Jesús, Mao Martín, Laura, Alonso Navarro, Rodrigo, Ampuero Martinich, Jose David, Barrós González, Raquel, Galindo Martín, María Aránzazu, Herrera Pacheco, Lourdes, Martínez Avilés, Rocío, Rodrigo González, Sara, Rodríguez Leal, Cristóbal Manuel, Romay Lema, Eva María, Suárez Gil, Roi, Ibarguren Pinilla, Maialen, Marimón Ortiz de Zárate, José María, Vidaur Tello, Loreto, Kortajarena Urkola, Xabier, García Gómez, Miriam, Aranguren Arostegui, Asier, Álvarez de Castro, Maria, Martínez Mateu, Cintia María, Rodríguez Gómez, Francisco, Muñoz Beamud, Francisco, Chamarro Martí, Elena, Cardona Rivera, Merce, Zakariya-Yousef Breval, Ismail, Rico Rodríguez, Marta, Llenas García, Jara, Sánchez Arenas, Mª Carmen, Fernández Cruz, Ana, Calderón Parra, Jorge, López Dosil, Marcos, Ramos Martínez, Antonio, Múñez Rubio, Elena, Callejas Díaz, Alejandro, Vázquez Comendador, José Manuel, Diego Yagüe, Itziar, Expósito Palomo, Esther, Anel Pedroche, Jorge, Álvarez Franco, Raquel, Fernández de Orueta, Lucía, Vates Gómez, Roberto, Cardona Arias, Andrés Felipe, Marguenda Contreras, Pablo, Gaspar Alonso-Vega, Gabriel, Aranda Rife, Elena María, Martínez Cifre, Blanca, Roger Zapata, Daniel, Martín Rubio, Irene, Barbosa Ventura, André, Piñero, Iván, Bahamonde Carrasco, Alberto, Runza Buznego, Paula, Talavera García, Eva, Lamata Subero, Marta, Urrutia Losada, Ainhoa, Arteche Eguizabal, Lorea, Delgado Sánchez, Elisabet, Molina Peinado, Virginia, Caro Bragado, Sarah, Domínguez de Pablos, Gema, Roldán Fontana, Carolina, Herrero Rodríguez, Carmen, Force Sanmartín, Luis, Aranega, Raquel, Mera Fidalgo, Arantzazu, Toda Savall, María Roca, Merchante Gutiérrez, Nicolas, León Jiménez, Eva María, Del Pozo, José Luís, Serralta Buades, Josefa, Cabrera Tejada, Ginger Giorgiana, Fernández-Ruiz, Mario, Aguado, José María, Maestro de la Calle, Guillermo, Cisneros, José Miguel, Pachón, Jerónimo, Aguilar-Guisado, Manuela, Aldabó, Teresa, Avilés, María Dolores, Bueno, Claudio, Cordero-Matía, Elisa, Escoresca, Ana, Gálvez-Benítez, Lydia, Infante, Carmen, Martín, Guillermo, Praena, Julia, Roca, Cristina, Salamanca, Celia, Suárez-Benjumea, Alejandro, Vizcarra, Pilar, Quereda, Carmen, Rodriguez Dominguez, Mario José, Gioia, Francesca, Norman, Francesca, Del Campo, Santos, Cantón Moreno, Rafael, Oteo Revuelta José, Antonio, Santibáñez Sáenz, Paula, Cervera Acedo, Cristina, Ruiz Martínez, Carlos, Blanco Ramos, José R., Azcona Gutiérrez, José M., García García, Concepción, Alba Fernández, Jorge, Ibarra Cucalón, Valvanera, San Franco, Mercedes, Metola Sacristán, Luis, Meijide Míguez, Héctor, Paulos Viñas, Silvia, Menéndez, Justo, Villares Fernández, Paula, Montes Andújar, Lara, Navarro Batet, Álvaro, Ferrer Santolaria, Anna, Padilla Salazar, María de la Luz, Abella Vázquez, Lucy, Hayek Peraza, Marcelino, García Pardo, Antonio, Hernández Carballo, Carolina, Ruiz Fernández, Andrés Javier, Barrio López, Isabel, Martakoush, Alí, Rojas-Vieyra, Agustín, García Calvo, Sonia, Villarreal García-Lomas, Mercedes, Vizcaíno Callejón, Marta, García García, María Pilar, Lérida Urteaga, Ana, Carrasco Fons, Natalia, María Sanjuan, Beatriz, Martín González, Lydia, Sanz Zamudio, Camilo, Jarrín, Inmaculada, Alejos, Belén, Moreno, Cristina, Rava, Marta, Iniesta, Carlos, Izquierdo, Rebeca, Suárez-García, Inés, Díaz, Asunción, Ruiz-Alguero, Marta, Hernando, Victoria, Rodríguez-Baño, Jesús, Yllescas, María, and Arriba, José Ramón

Published
2020
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4. Genetic characteristics involved in COVID‐19 severity. The CARGENCORS case‐control study and meta‐analysis

Author

Camps‐Vilaró, Anna, primary, Pinsach‐Abuin, Mel·lina, additional, Degano, Irene R., additional, Ramos, Rafel, additional, Martí‐Lluch, Ruth, additional, Elosua, Roberto, additional, Subirana, Isaac, additional, Solà‐Richarte, Clàudia, additional, Puigmulé, Marta, additional, Pérez, Alexandra, additional, Vilaró, Ingrid, additional, Cruz, Raquel, additional, Diz‐de Almeida, Silvia, additional, Nogues, Xavier, additional, Masclans, Joan R., additional, Güerri‐Fernández, Roberto, additional, Marin, Judith, additional, Tizon‐Marcos, Helena, additional, Vaquerizo, Beatriz, additional, Brugada, Ramon, additional, and Marrugat, Jaume, additional

Published
2024
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6. Switching to Dolutegravir/lamivudine or Bictegravir/Emtricitabine/Tenofovir alafenamide. A comparative real-world study.

Author

Knobel, Hernando, Cañas-Ruano, Esperanza, Guelar, Ana, Knobel, Pablo, Villar-García, Judit, González-Mena, Alicia, Canepa, Ceclia, Arrieta-Aldea, Itziar, Marcos, Augustin, Abalat-Torrres, Agustí, and Güerri-Fernández, Roberto

Subjects
LAMIVUDINE, TENOFOVIR, DOLUTEGRAVIR, EMTRICITABINE, RITONAVIR, TERMINATION of treatment, HIV-positive persons, COMPARATIVE studies
Abstract

This real-world study compared the safety and effectiveness of Dolutegravir/lamivudine (D/L) and Bictegravir/Emtricitabine/Tenefovir alafenamide (B/F/T) switch therapy regimens for people living with HIV (PLWH) The retrospective study conducted from April 2019 to November 2022, included PLWH with < 50 copies/mL of HIV-RNA prior to recruitment who initiated either D/L or B/F/T switching therapy. The primary objective was to evaluate treatment discontinuation rates; safety and virologic outcomes were also evaluated. 690 PLWH were included, 358 in the D/L and 332 in the B/F/T, and a median follow-up of 728 and 1013 days, respectively. The discontinuation proportions were 8.7% (31 participants, incidence rate of 4.44 per 100 PYFU in the D/L group and 15.3% (51 participants, incidence rate of 6.25 per 100 PYFU) in the B/F/T group. The adjusted hazard ratio for B/F/T discontinuation compared to D/L was 1.20 (95% CI: 0.71;2.0; p = 0.494). Virologic failure (VL > 200 copies/mL in two consecutive measurements) occurred in 1.1% and 0.9% of patients in the D/L and B/F/T groups, respectively. Notably, one patient in D/L group with severe non-adherence and virologic failure developed resistance mutations. Switching to either B/T/F or D/L treatment for PLWH was effective and well tolerated in this real-world study. Treatment discontinuation rates did not significantly differ between the two regimens. [ABSTRACT FROM AUTHOR]

Published
2023
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7. Antibiotic desensitization as a potential tool in antimicrobial stewardship programs: retrospective data analysis and systematic literature review

Author

Rodríguez-Alarcón, Alicia, primary, Barceló-Vidal, Jaime, additional, Echeverría-Esnal, Daniel, additional, Sorli, Luisa, additional, Güerri-Fernández, Roberto, additional, Ramis Fernández, Sofía Martina, additional, Benitez-Cano, Adela, additional, Sendra, Elena, additional, López Montesinos, Inmaculada, additional, Membrilla-Fernández, Estela, additional, Ferrández, Olivia, additional, Adalia, Ramón, additional, Horcajada, Juan Pablo, additional, Escolano, Fernando, additional, Gómez-Zorrilla, Silvia, additional, and Grau, Santiago, additional

Published
2022
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8. Comparison of hospitalized COVID-19 and influenza patients requiring supplemental oxygen in a cohort study: clinical impact and resource consumption

Author

López Montesinos, Inmaculada, Arrieta Aldea, Itziar, Dicastillo, Aitor, Zuccarino, Flavio, Sorli Redó, M. Luisa, Güerri Fernández, Roberto, Arnau-Barrés, Isabel, Milagro Montero, Maria, Siverio-Parès, Ana, Duran Jordà, Xavier, 1974, Arenas-Miras, María Del Mar, Brasé Arnau, Ariadna, Cañas-Ruano, Esperanza, Castañeda, Silvia, Kamber, Ignacio Domingo, Gómez Junyent, Joan, Pelegrín, Iván, Sánchez Martínez, Francisca, Sendra, Elena, Suaya Leiro, Lucía, Villar García, Judit, Nogués Solan, Francesc Xavier, Grau Cerrato, Santiago, Knobel Freud, Hernando, Gómez-Zorrilla, Silvia, Horcajada Gallego, Juan Pablo, and COVID-MAR Group

Subjects
Flu, Pandemic, COVID-19, Resource consumption, Mortality, Hospital costs
Abstract

Data de publicació electrònica: 20-04-2022 Background: To compare clinical characteristics, outcomes, and resource consumption of patients with COVID-19 and seasonal influenza requiring supplemental oxygen. Methods: Retrospective cohort study conducted at a tertiary-care hospital. Patients admitted due to seasonal influenza between 2017 and 2019, or with COVID-19 between March and May 2020 requiring supplemental oxygen were compared. Primary outcome: 30-day mortality. Secondary outcomes: 90-day mortality and hospitalization costs. Attempted sample size to detect an 11% difference in mortality was 187 patients per group. Results: COVID-19 cases were younger (median years, 67 (IQR 54-78) vs 76 (IQR 64-83); p < 0.001) and more frequently overweight whereas influenza cases had more hypertension, immunosuppression, and chronic heart, respiratory and renal disease. Compared to influenza, COVID-19 cases had more pneumonia (98% vs 60%

Published
2022

11. COVID-19 in elderly kidney transplant recipients

Author

Crespo, Marta, Pérez-Sáez, María J., Redondo-Pachón, Dolores, Llinàs-Mallol, Laura, Montero, María M., Villar-García, Judith, Arias-Cabrales, Carlos, Buxeda, Anna, Burballa, Carla, Vázquez, Susana, López, Thais, Moreno, Fátima, Mir, Marisa, Outón, Sara, Sierra, Adriana, Collado, Silvia, Barrios, Clara, Rodríguez, Eva, Sans, Laia, Barbosa, Francesc, Cao, Higini, Arenas, María D., Güerri-Fernández, Roberto, Horcajada, Juan P., and Pascual, Julio

Published
2020
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12. Test rápidos de antígenos para la detección del SARS-CoV-2: Revisión narrativa

Author

Aguilar-Shea, Antonio L., Vera-García, Mar, and Güerri Fernández, Roberto

Subjects
SARS-CoV-2, Test de antígenos, Diagnóstico, Point-of-care, Diagnosis, Rápido, COVID-19, Antigen test, Centró de atención médica, Rapid
Abstract

The rapid identificationand isolation of COVID-19 patients has become the cornerstone for the control of the recent outbreak. Real-time quantitative polymerase chain reaction is routinely used to confirm COVID-19 diagnosis and is considered the gold standard due to high sensitivity and specificity. Nevertheless, it usually takes several days and a relatively higher cost. Antigen tests based have emerged to cope with such disadvantages, by offering rapid results, an easy-to-use procedure, and low costs. The objective of the narrative review was to provide up-to-date data about CE-marked rapid antigen tests (RATs) for COVID-19. Given their large number, the study only focused on representative and widely used in Spain (Standard Q, Nadal, Panbio, CerTest, and Wondfo). RATs have become a very useful and validated tool for controlling the spread of COVID-19 allowing the rapid identification of active infection and isolation of positive patients. The present revision of the literature has demonstrated that sensitivity and specificity of all available RATs in Spain are high and accomplish European regulations and WHO recommendations. La rápida identificación y aislamiento de los pacientes por COVID-19 se ha convertido en un reto para el control de la pandemia. La reacción en cadena de la polimerasa cuantitativa a tiempo real se utiliza de manera rutinaria para confirmar el diagnóstico de COVID-19 y se considera el estándar de referencia por su alta sensibilidad y especificidad. Sin embargo, normalmente lleva varios días y los costes son relativamente altos. Los test de antígeno son una herramienta rápida, fácil de realizar y de bajo coste. El objetivo de la revisión narrativa es proporcionar información actualizada sobre los test rápidos de antígenos (TRA) para COVID-19 con marcado europeo. Dado su gran número, el estudio solo se enfoca en aquellos representativos y ampliamente empleados en España (Standard Q, Nadal, Panbio, CerTest y Wondfo). Los TRA se han convertido en una herramienta validada muy útil para controlar la diseminación de la COVID-19, al permitir la identificación rápida de la infección activa y el aislamiento de pacientes positivos. La presente revisión de la literatura ha demostrado que la sensibilidad y especificidad de los TRA disponibles en España son altas y cumplen con la regulación europea y las recomendaciones de la OMS.

Published
2021

13. Impact of a Nosocomial COVID-19 Outbreak on a Non-COVID-19 Nephrology Ward during the First Wave of the Pandemic in Spain

Author

Montero, María Milagro, primary, Hidalgo López, Carlota, additional, López Montesinos, Inmaculada, additional, Sorli, Luisa, additional, Barrufet Gonzalez, Cristina, additional, Villar-García, Judith, additional, Güerri-Fernández, Roberto, additional, Herranz, Milagros, additional, Crespo, Marta, additional, Arenas Jiménez, María Dolores, additional, Pascual, Julio, additional, González Juanes, Cristina, additional, and Horcajada, Juan P., additional

Published
2021
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14. Characteristics and predictors of death among 4035 consecutively hospitalized patients with COVID-19 in Spain

Author

Berenguer, Juan, primary, Ryan, Pablo, additional, Rodríguez-Baño, Jesús, additional, Jarrín, Inmaculada, additional, Carratalà, Jordi, additional, Pachón, Jerónimo, additional, Yllescas, María, additional, Arriba, José Ramón, additional, Aznar Muñoz, Esther, additional, Gil Divasson, Pedro, additional, González Muñiz, Patricia, additional, Muñoz Aguirre, Clara, additional, López, Juan Carlos, additional, Ramírez-Schacke, Margarita, additional, Gutiérrez, Isabel, additional, Tejerina, Francisco, additional, Aldámiz-Echevarría, Teresa, additional, Díez, Cristina, additional, Fanciulli, Chiara, additional, Pérez-Latorre, Leire, additional, Parras, Francisco, additional, Catalán, Pilar, additional, García-Leoni, María E., additional, Pérez-Tamayo, Isabel, additional, Puente, Luis, additional, Cedeño, Jamil, additional, Berenguer, Juan, additional, Díaz Menéndez, Marta, additional, de la Calle Prieto, Fernando, additional, Arsuaga Vicente, Marta, additional, Trigo Esteban, Elena, additional, Lago Núñez, Mª del Mar, additional, de Miguel Buckley, Rosa, additional, Cadiñaños Loidi, Julen, additional, Busca Arenzana, Carmen, additional, Mican, Alfredo, additional, Mora Rillo, Marta, additional, Ramos Ramos, Juan Carlos, additional, Loeches Yagüe, Belén, additional, Bernardino de la Serna, José Ignacio, additional, García Rodríguez, Julio, additional, Arribas López, José Ramón, additional, Such Diaz, Ana, additional, Álvaro Alonso, Elena, additional, Izquierdo García, Elsa, additional, Torres Macho, Juan, additional, Cuevas Tascon, Guillermo, additional, Troya García, Jesús, additional, Mestre Gómez, Beatriz, additional, Jiménez González de Buitrago, Eva, additional, Fernández Jiménez, Inés, additional, Tebar Martínez, Ana Josefa, additional, Brañas Baztán, Fátima, additional, Valencia de la Rosa, Jorge, additional, Pérez Butragueño, Mario, additional, Alvarado Blasco, Marta, additional, Sepúlveda Berrocal, Mª Antonia, additional, Yera Bergua, Carmen, additional, Toledano Sierra, Pilar, additional, Cano Llorente, Verónica, additional, Zafar Iqubal-Mirza, Sadaf, additional, Muñiz, Gema, additional, Martín Pérez, Inmaculada, additional, Mozas Moriñigo, Helena, additional, Alguacil, Ana, additional, García Butenegro, María Paz, additional, Peláez Ballesta, Ana Isabel, additional, Morcillo Rodríguez, Elena, additional, Goikoetxea Agirre, Josune, additional, Blanco Vidal, María José, additional, Nieto Arana, Javier, additional, del Álamo Martínez de Lagos, Mikel, additional, Pérez Hernández, Isabel A., additional, Pérez Zapata, Inés, additional, Silvariño Fernández, Rafael, additional, Ugalde Espiñeira, Jon, additional, Asensi Álvarez, Víctor, additional, Suárez Pérez, Lucia, additional, Suárez Diaz, Silvia, additional, Yllera Gutiérrez, Carmen, additional, Boix, Vicente, additional, Díez Martínez, Marcos, additional, Carreres Candela, Melissa, additional, Gómez-Ayerbe, Cristina, additional, Sánchez-Lora, Javier, additional, Velasco Garrido, José Luis, additional, López-Jódar, María, additional, Santos González, Jesús, additional, Ruiz Aragón, Jesús, additional, Virto Peña, Ianire, additional, Alende Castro, Vanessa, additional, Brea Aparicio, Ruth, additional, Vega Molpeceres, Sonia, additional, Pons Viñas, Estel, additional, del Río Pérez, Oscar, additional, Valero Rovira, Silvia, additional, Villar-García, Judit, additional, Gómez-Junyent, Joan, additional, Knobel, Hernando, additional, Cánepa, María Cecilia, additional, Castañeda Espinosa, Silvia, additional, Sorli Redò, Luisa, additional, Güerri-Fernández, Roberto, additional, Milagro Montero, María, additional, Horcajada, Juan Pablo, additional, García Vázquez, Elisa, additional, Moral Escudero, Encarnación, additional, Hernández Torres, Alicia, additional, García Almodóvar, Esther, additional, Sáez Barberá, Carmen, additional, Karroud, Zineb, additional, Hernández Quero, José, additional, Vinuesa García, David, additional, García Fogeda, José Luis, additional, Peregrina, José Antonio, additional, Novella Mena, María, additional, Hernández Gutiérrez, Cristina, additional, Sanz Moreno, José, additional, Pérez Tanoira, Ramón, additional, Sierra Rodríguez, Rodrigo, additional, Alonso Menchén, David, additional, Gutiérrez García, Aida, additional, Arranz Caso, Alberto, additional, Cuadros González, Juan, additional, Álvarez de Mon Soto, Melchor, additional, Díaz de Brito Fernández, Vicente Ferrer, additional, Sanmarti Vilamala, Montserrat, additional, Gabarrell Pascuet, Aina, additional, Molina Morant, Daniel, additional, España Cueto, Sergio, additional, Cámara Fernández, Jonathan, additional, Sabater Gil, Albert, additional, Muñoz López, Laura, additional, Sáez Escolano, Paula, additional, Bejarano Tello, Esperanza, additional, Sempere Alcocer, Marco Antonio, additional, Álvarez Martin, Salvador, additional, De los Santos Gil, Ignacio, additional, García-Fraile, Lucio, additional, Sampedro Núñez, Miguel, additional, Barrios Blandino, Ana, additional, Rodríguez Franco, Carlos, additional, Useros Brañas, Daniel, additional, Villa Martí, Almudena, additional, Oliver Ortega, Javier, additional, Costanza Espiño Álvarez, Alexia, additional, Sanz Sanz, Jesús, additional, Rexach Fumaña, María, additional, Abascal Cambras, Ivette, additional, Pérez Jaén, Ana del Cielo, additional, Sala Jofre, Clara, additional, Casas Rodríguez, Susana, additional, Tortajada Alamilla, Cecilia, additional, Oltra, Carmina, additional, Masiá Canuto, Mar, additional, Gutiérrez Rodero, Félix, additional, Ferrer Ribera, Ana, additional, Bea Serrano, Carlos, additional, Pedromingo Kus, Miguel, additional, Garcinuño, María Ángeles, additional, Fiorante, Silvana, additional, Pérez Pinto, Sergio, additional, Hernández Machín, Pilar, additional, Alastrué Violeta, Alba, additional, Fariñas Álvarez, María Carmen, additional, González Rico, Claudia, additional, Arnaiz de las Revillas, Francisco, additional, Calvo, Jorge, additional, Gozalo, Mónica, additional, Mora Gómez, Francisco, additional, Milagro Beamonte, Ana, additional, Latorre-Millán, Miriam, additional, Rezusta López, Antonio, additional, Martínez Sapiña, Ana, additional, Meije, Yolanda, additional, Duarte Borges, Alejandra, additional, Pareja Coca, Julia, additional, Clemente Presas, Mercedes, additional, Losa García, Juan Emilio, additional, Vegas Serrano, Ana, additional, Pérez-Rodríguez, M. Teresa, additional, Pérez González, Alexandre, additional, Belhassen-García, Moncef, additional, Rodríguez-Alonso, Beatriz, additional, López-Bernus, Amparo, additional, Carbonell, Cristina, additional, Torres Perea, Rafael, additional, Cantón de Seoane, Juan, additional, Alonso, Blanca, additional, Kamal, Sara Lidia, additional, Cajuela, Lucia, additional, Roa, David, additional, Cervero, Miguel, additional, Oreja, Alberto, additional, Avilés, Juan Pablo, additional, Martín, Lidia, additional, Pelegrín Senent, Iván, additional, Rouco Esteves Marques, Rosana, additional, Parra Ruiz, Jorge, additional, Ramos Sesma, Violeta, additional, Abadia Otero, Jessica, additional, Salillas Hernando, Juan, additional, Torres Sánchez del Arco, Robert, additional, Torralba González de Suso, Miguel, additional, Serrano Martínez, Alberto, additional, Gilaberte Reyzábal, Sergio, additional, Pacheco Martínez-Atienza, Marina, additional, Liébana Gómez, Mónica, additional, Fernández Rodríguez, Sara, additional, Varela Plaza, Álvaro, additional, Calvo Sánchez, Henar, additional, Martínez Martín, Patricia, additional, González- Ruano, Patricia, additional, Malmierca Corral, Eduardo, additional, Rábago Lorite, Isabel, additional, Pérez-Monte Mínguez, Beatriz, additional, García Flores, Ángeles, additional, Comas Casanova, Pere, additional, Sirisi, Merce, additional, Rojas, Richard, additional, Díaz de Tuesta del Arco, José Luis, additional, Figueroa Cerón, Ruth, additional, González Sarria, Ander, additional, Alemán Valls, Remedios, additional, Alonso Socas, María del Mar, additional, Sanz Peláez, Oscar, additional, Mohamed Ramírez, Karim, additional, Riera Jaume, Melchor, additional, Vilchez, Helem Haydee, additional, Albertí, Francesc, additional, Cañabate, Ana Isabel, additional, Moreno Cuerda, Víctor J., additional, Álvarez Kaelis, Silvia, additional, Álvarez Zapatero, Beatriz, additional, García García, Alejandro, additional, Isaba Ares, Elena, additional, Morcate Fernández, Covadonga, additional, Pérez Rodríguez, Andrea, additional, Ramos Merino, Lucía, additional, Castelo Corral, Laura, additional, Rodríguez Mahía, María, additional, González Bardanca, Mónica, additional, Sánchez Vidal, Efrén, additional, Míguez Rey, Enrique, additional, De la Torre Lima, Javier, additional, García de Lomas Guerrero, José Mª, additional, Morte, Elena, additional, Loscos, Silvia, additional, Camón, Ana, additional, Gómez García, Lucía, additional, Boix Palop, Lucia, additional, Dietl Gómez-Luengo, Beatriz, additional, Pedrola Gorrea, Iris, additional, Blasco Claramunt, Amparo, additional, López Mestanza, Cristina, additional, Fraile Villarejo, Esther, additional, Tosco Núñez, Tomás, additional, Aroca Ferri, María, additional, Algado Rabasa, José Tomas, additional, Garijo Saiz, Ana María, additional, Amador Prous, Concepción, additional, Baño, Jesús Rodriguez, additional, Retamar, Pilar, additional, Valiente, Adoración, additional, López-Cortés, Luis E., additional, Sojo, Jesús, additional, Gutiérrez-Gutiérrez, Belén, additional, Bravo-Ferrer, José, additional, Salamanca, Elena, additional, Palacios, Zaira R., additional, Pérez-Palacios, Patricia, additional, Peral, Enrique, additional, Pérez de León, José Antonio, additional, Sánchez-Gómez, Jesús, additional, Marín-Barrera, Lucía, additional, García-Jiménez, Domingo, additional, Abelenda-Alonso, Gabriela, additional, Ardanuy, Carmen, additional, Bergas, Alba, additional, Cuervo, Guillermo, additional, Domínguez, María Ángeles, additional, Fernández-Huerta, Miguel, additional, Gudiol, Carlota, additional, Lorenzo-Esteller, Laia, additional, Niubó, Jordi, additional, Pérez-Recio, Sandra, additional, Podzamczer, Daniel, additional, Pujol, Miquel, additional, Rombauts, Alexander, additional, Trullen, Núria, additional, Salavert Lletí, Miguel, additional, Castro Hernández, Iván, additional, Hernández Belmonte, Adriana, additional, Martínez Goñi, Raquel, additional, Navarro Vilasaró, Marta, additional, Calzado Isbert, Sonia, additional, Cervantes García, Manuel, additional, Gomila Grange, Aina, additional, Gasch Blasi, Oriol, additional, Machado Sicilia, María Luisa, additional, Van den Eynde Otero, Eva, additional, Falgueras López, Luis, additional, Navarro Sáez, María del Carmen, additional, Martínez, Esteban, additional, Marcos, Mª Ángeles, additional, Mosquera, Mar, additional, Blanco, José Luis, additional, Laguno, Montserrat, additional, Rojas, Jhon, additional, González-Cordón, Ana, additional, Inciarte, Alexy, additional, Torres, Berta, additional, De la Mora, Lorena, additional, Soriano, Alex, additional, Martínez Macias, Olalla, additional, Pérez Doñate, Virginia, additional, Cabello Úbeda, Alfonso, additional, Carrasco Antón, Nerea, additional, Álvarez Álvarez, Beatriz, additional, Petkova Saiz, Elizabet, additional, Górgolas Hernández-Mora, Miguel, additional, Prieto Pérez, Laura, additional, Carrillo Acosta, Irene, additional, Heili Frades, Sara, additional, Villar Álvarez, Felipe, additional, Fernández Roblas, Ricardo, additional, Milicua Muñoz, José María, additional, Fernández Espinilla, Virginia, additional, Dueñas Gutiérrez, Carlos Jesús, additional, Hernán García, Cristina, additional, González-Romo, Fernando, additional, Merino Amador, Paloma, additional, Rueda López, Alba, additional, Martínez Jordán, Jorge, additional, Medrano Pardo, Sara, additional, Díaz de la Torre, Irene, additional, Posada Franco, Yolanda, additional, Delgado-Iribarren, Alberto, additional, López-Contreras González, Joaquín, additional, Pascual Alonso, Pablo, additional, Pomar Solchaga, Virginia, additional, Rabella García, Nuria, additional, Benito Hernández, Natividad, additional, Domingo Pedrol, Pere, additional, Bonfill Cosp, Xavier, additional, Padrós Selma, Rafael, additional, Puig Campmany, Mireia, additional, Mancebo Cortés, Jordi, additional, Gurguí Ferrer, Mercè, additional, Íñigo Pestaña, Melania, additional, Pérez García, Alejandra, additional, Sorní Moreno, Patricia, additional, Izko Gartzia, Nora, additional, Membrillo de Novales, Francisco Javier, additional, Simón Sacristán, María, additional, Zamora Cintas, Maribel, additional, Martínez Martínez, Yolanda, additional, Fernández-González, Pablo, additional, Alcántara Nicolás, Francisco, additional, Aguirre Vila-Cora, Alejandro, additional, López Tizón, Elena, additional, Ramírez-Olivencia, Germán, additional, Estébanez Muñoz, Miriam, additional, Sáez de Adana Arróniz, Ester, additional, Portu Zapirain, Joseba, additional, Gainzarain Arana, Juan Carlos, additional, Ortiz de Zárate Ibarra, Zuriñe, additional, Moran Rodríguez, Miguel Ángel, additional, Canut Blasco, Andrés, additional, Hernáez Crespo, Silvia, additional, Balerdi Sarasola, Leire, additional, Morales García, Cristina, additional, Corral Saracho, Miguel, additional, Valcarce González, Zeltia, additional, Arenal Andrés, Noelia, additional, Rodríguez Tarazona, Raquel Elisa, additional, Iglesias Llorente, Laura, additional, Loureiro Rodríguez, Beatriz, additional, Sánchez Montalvá, Adrián, additional, Espinosa Pereiro, Juan, additional, Almirante, Benito, additional, Miarons, Marta, additional, Sellarés, Júlia, additional, Larrosa, María, additional, García, Sonia, additional, Marzo, Blanca, additional, Villamarín, Miguel, additional, Fernández, Nuria, additional, Pérez-Jorge Peremarch, Conchita, additional, Resino Foz, Elena, additional, Espigares Correa, Andrea, additional, Álvarez de Espejo Montiel, Teresa, additional, Navas Clemente, Iván, additional, Quijano Contreras, María Isabel, additional, Nieto Fernández del Campo, Luis Alberto, additional, Jiménez Álvarez, Guillermo, additional, Guillamón Sánchez, Mercedes, additional, García García, Josefina, additional, Muñoz Hornero, Constanza, additional, Mariño Callejo, Ana, additional, Valcarce Pardeiro, Nieves, additional, Smithson Amat, Alex, additional, Chico Chumillas, Cristina, additional, Sánchez Serrano, Adriana, additional, García Villalba, Eva Pilar, additional, Jiménez Martínez, Isabel, additional, Estrada Fernández, Guillermo, additional, Lorén Vargas, María, additional, Parra Arribas, Nuria, additional, Martínez Cilleros, Carmen, additional, Villasante de la Puente, Aránzazu, additional, García Delange, Teresa, additional, Ruiz Rodríguez, María José, additional, Robledo del Prado, Marta, additional, Abad Almendro, Juan Carlos, additional, Muñoz del Rey, José Román, additional, Jiménez Álvaro, Montaña, additional, Coy Coy, Javier, additional, Poquet Catala, Inmaculada, additional, Santos Peña, Marta, additional, Naranjo Velasco, Virginia, additional, Manso Gómez, Tamara, additional, Quilez Ágreda, Delia, additional, Barbeito Castiñeiras, Gema, additional, Domínguez Santalla, María Jesús, additional, Mao Martín, Laura, additional, Alonso Navarro, Rodrigo, additional, Ampuero Martinich, Jose David, additional, Barrós González, Raquel, additional, Galindo Martín, María Aránzazu, additional, Herrera Pacheco, Lourdes, additional, Martínez Avilés, Rocío, additional, Rodrigo González, Sara, additional, Rodríguez Leal, Cristóbal Manuel, additional, Romay Lema, Eva María, additional, Suárez Gil, Roi, additional, Ibarguren Pinilla, Maialen, additional, Marimón Ortiz de Zárate, José María, additional, Vidaur Tello, Loreto, additional, Kortajarena Urkola, Xabier, additional, García Gómez, Miriam, additional, Aranguren Arostegui, Asier, additional, Álvarez de Castro, Maria, additional, Martínez Mateu, Cintia María, additional, Rodríguez Gómez, Francisco, additional, Muñoz Beamud, Francisco, additional, Chamarro Martí, Elena, additional, Cardona Rivera, Merce, additional, Zakariya-Yousef Breval, Ismail, additional, Rico Rodríguez, Marta, additional, Llenas García, Jara, additional, Sánchez Arenas, Mª Carmen, additional, Fernández Cruz, Ana, additional, Calderón Parra, Jorge, additional, López Dosil, Marcos, additional, Ramos Martínez, Antonio, additional, Múñez Rubio, Elena, additional, Callejas Díaz, Alejandro, additional, Vázquez Comendador, José Manuel, additional, Diego Yagüe, Itziar, additional, Expósito Palomo, Esther, additional, Anel Pedroche, Jorge, additional, Álvarez Franco, Raquel, additional, Fernández de Orueta, Lucía, additional, Vates Gómez, Roberto, additional, Cardona Arias, Andrés Felipe, additional, Marguenda Contreras, Pablo, additional, Gaspar Alonso-Vega, Gabriel, additional, Aranda Rife, Elena María, additional, Martínez Cifre, Blanca, additional, Roger Zapata, Daniel, additional, Martín Rubio, Irene, additional, Barbosa Ventura, André, additional, Piñero, Iván, additional, Bahamonde Carrasco, Alberto, additional, Runza Buznego, Paula, additional, Talavera García, Eva, additional, Lamata Subero, Marta, additional, Urrutia Losada, Ainhoa, additional, Arteche Eguizabal, Lorea, additional, Delgado Sánchez, Elisabet, additional, Molina Peinado, Virginia, additional, Caro Bragado, Sarah, additional, Domínguez de Pablos, Gema, additional, Roldán Fontana, Carolina, additional, Herrero Rodríguez, Carmen, additional, Force Sanmartín, Luis, additional, Aranega, Raquel, additional, Mera Fidalgo, Arantzazu, additional, Toda Savall, María Roca, additional, Merchante Gutiérrez, Nicolas, additional, León Jiménez, Eva María, additional, Del Pozo, José Luís, additional, Serralta Buades, Josefa, additional, Cabrera Tejada, Ginger Giorgiana, additional, Fernández-Ruiz, Mario, additional, Aguado, José María, additional, Maestro de la Calle, Guillermo, additional, Cisneros, José Miguel, additional, Aguilar-Guisado, Manuela, additional, Aldabó, Teresa, additional, Avilés, María Dolores, additional, Bueno, Claudio, additional, Cordero-Matía, Elisa, additional, Escoresca, Ana, additional, Gálvez-Benítez, Lydia, additional, Infante, Carmen, additional, Martín, Guillermo, additional, Praena, Julia, additional, Roca, Cristina, additional, Salamanca, Celia, additional, Suárez-Benjumea, Alejandro, additional, Vizcarra, Pilar, additional, Quereda, Carmen, additional, Rodriguez Dominguez, Mario José, additional, Gioia, Francesca, additional, Norman, Francesca, additional, Del Campo, Santos, additional, Cantón Moreno, Rafael, additional, Oteo Revuelta José, Antonio, additional, Santibáñez Sáenz, Paula, additional, Cervera Acedo, Cristina, additional, Ruiz Martínez, Carlos, additional, Blanco Ramos, José R., additional, Azcona Gutiérrez, José M., additional, García García, Concepción, additional, Alba Fernández, Jorge, additional, Ibarra Cucalón, Valvanera, additional, San Franco, Mercedes, additional, Metola Sacristán, Luis, additional, Meijide Míguez, Héctor, additional, Paulos Viñas, Silvia, additional, Menéndez, Justo, additional, Villares Fernández, Paula, additional, Montes Andújar, Lara, additional, Navarro Batet, Álvaro, additional, Ferrer Santolaria, Anna, additional, Padilla Salazar, María de la Luz, additional, Abella Vázquez, Lucy, additional, Hayek Peraza, Marcelino, additional, García Pardo, Antonio, additional, Hernández Carballo, Carolina, additional, Ruiz Fernández, Andrés Javier, additional, Barrio López, Isabel, additional, Martakoush, Alí, additional, Rojas-Vieyra, Agustín, additional, García Calvo, Sonia, additional, Villarreal García-Lomas, Mercedes, additional, Vizcaíno Callejón, Marta, additional, García García, María Pilar, additional, Lérida Urteaga, Ana, additional, Carrasco Fons, Natalia, additional, María Sanjuan, Beatriz, additional, Martín González, Lydia, additional, Sanz Zamudio, Camilo, additional, Alejos, Belén, additional, Moreno, Cristina, additional, Rava, Marta, additional, Iniesta, Carlos, additional, Izquierdo, Rebeca, additional, Suárez-García, Inés, additional, Díaz, Asunción, additional, Ruiz-Alguero, Marta, additional, and Hernando, Victoria, additional

Published
2020
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15. Clinical Profiles in Renal Patients with COVID-19

Author

Arenas, María Dolores, primary, Crespo, Marta, additional, Pérez-Sáez, María José, additional, Collado, Silvia, additional, Redondo-Pachón, Dolores, additional, Llinàs-Mallol, Laura, additional, Montero, María Milagro, additional, Villar-García, Judith, additional, Arias-Cabrales, Carlos, additional, Barbosa, Francesc, additional, Buxeda, Anna, additional, Burballa, Carla, additional, Sans, Laia, additional, Vázquez, Susana, additional, Oliveras, Anna, additional, Mir, Marisa, additional, Outón, Sara, additional, Galcerán, Isabel, additional, Solá, Eulalia, additional, Sierra, Adriana, additional, Barrios, Clara, additional, Rodríguez, Eva, additional, Cao, Higini, additional, Güerri-Fernández, Roberto, additional, Horcajada, Juan Pablo, additional, and Pascual, Julio, additional

Published
2020
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16. COVID-19 in Grade 4–5 Chronic Kidney Disease Patients

Author

Collado, Silvia, primary, Arenas, María Dolores, additional, Barbosa, Francesc, additional, Cao, Higini, additional, Montero, María Milagro, additional, Villar-García, Judit, additional, Barrios, Clara, additional, Rodríguez, Eva, additional, Sans, Laia, additional, Sierra, Adriana, additional, Pérez-Sáez, María José, additional, Redondo-Pachón, Dolores, additional, Coca, Armando, additional, Maiques, José María, additional, Güerri-Fernández, Roberto, additional, Horcajada, Juan Pablo, additional, Crespo, Marta, additional, and Pascual, Julio, additional

Published
2020
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18. Assessment of Bone Health in Patients With Type 1 Gaucher Disease Using Impact Microindentation

Author

Herrera, Sabina, primary, Pérez-López, Jordi, additional, Moltó-Abad, Marc, additional, Güerri-Fernández, Roberto, additional, Cabezudo, Elena, additional, Novelli, Silvana, additional, Esteve, Jordi, additional, Hernández, Albert, additional, Roig, Inmaculada, additional, Solanich, Xavier, additional, Prieto-Alhambra, Daniel, additional, Nogués, Xavier, additional, and Díez-Pérez, Adolfo, additional

Published
2017
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21. Validation Protocol of Vitamin D Supplementation in Patients with HIV-Infection

Author

Lerma-Chippirraz, Elisabet, primary, Güerri-Fernández, Roberto, additional, Villar García, Judit, additional, González Mena, Alicia, additional, Guelar Grinberg, Ana, additional, Montero, María Milagro, additional, Sorli, Luisa, additional, Calzado, Sonia, additional, Horcajada, Juan Pablo, additional, Díez-Pérez, Adolfo, additional, and Knobel Freud, Hernando, additional

Published
2016
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24. Microindentation for in vivo measurement of bone tissue material properties in atypical femoral fracture patients and controls

Author

Güerri-Fernández, Roberto C, primary, Nogués, Xavier, additional, Quesada Gómez, José M, additional, Torres del Pliego, Elisa, additional, Puig, Lluís, additional, García-Giralt, Natalia, additional, Yoskovitz, Guy, additional, Mellibovsky, Leonardo, additional, Hansma, Paul K, additional, and Díez-Pérez, Adolfo, additional

Published
2012
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28. Microindentation for in vivo measurement of bone tissue material properties in atypical femoral fracture patients and controls.

Author

Güerri-Fernández, Roberto C, Nogués, Xavier, Quesada Gómez, José M, Torres del Pliego, Elisa, Puig, Lluís, García-Giralt, Natalia, Yoskovitz, Guy, Mellibovsky, Leonardo, Hansma, Paul K, and Díez-Pérez, Adolfo

Abstract

Atypical femoral fractures (AFF) associated with long-term bisphosphonates (LTB) are a growing concern. Their etiology is unknown, but bone material properties might be deteriorated. In an AFF series, we analyzed the bone material properties by microindentation. Four groups of patients were included: 6 AFF, 38 typical osteoporotic fractures, 6 LTB, and 20 controls without fracture. Neither typical osteoporotic fractures nor controls have received any antiosteoporotic medication. A general laboratory workup, bone densitometry by dual-energy X-ray absorptiometry (DXA), and microindentation testing at the tibia were done in all patients. Total indentation distance (Total ID), indentation distance increase (IDI), and creep indentation distance (Creep ID) were measured (microns). Age-adjusted analysis of covariance (ANCOVA) was used for comparisons. Controls were significantly younger than fracture groups. Bisphosphonate exposure was on average 5.5 years (range 5 to 12 years) for the AFF and 5.4 years (range 5 to 8 years) for the LTB groups. Total ID (microns) showed better material properties (lower Total ID) for controls 36 (± 6; mean ± SD) than for AFF 46 (± 4) and for typical femoral fractures 47 (± 13), respectively. Patients on LTB showed values between controls and fractures, 38 (± 4), although not significantly different from any of the other three groups. IDI values showed a similar pattern 13 (± 2), 16 (± 6), 19 (± 3), and 18 (± 5). After adjusting by age, significant differences were seen between controls and typical (p < 0.001) and atypical fractures ( p = 0.03) for Total ID and for IDI ( p < 0.001 and p < 0.05, respectively). There were no differences in Creep ID between groups. Our data suggest that patients with AFF have a deep deterioration in bone material properties at a tissue level similar to that for the osteoporotic fracture group. The LTB group shows levels that are in between controls and both type of fractures, although not statistically different. These results suggest that bisphosphonate therapy probably does not put the majority of patients at risk for AFF. © 2013 American Society for Bone and Mineral Research [ABSTRACT FROM AUTHOR]

Published
2013
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29. Estudio de los factores pronósticos y terapéutica de la sepsis grave en el paciente anciano y muy anciano

Author

Arnau-Barrés, Isabel, Miralles Basseda, Ramon, Güerri-Fernández, Robert, and Güerri Fernández, Roberto Carlos

Subjects
Sars-Cov-2, Ancià, Adulto mayor, Sepsis, Older adults, Sèpsia, Ciències de la Salut
Abstract

Una de les complicacions més freqüents als pacients d’edat avançada són les infeccions. A la present tesi s’han estudiat dos grups de pacients majors de 65 anys amb infeccions greus (un grup de pacients amb sèpsia i un amb infecció per SARS-CoV-2). La metodologia empleada, les variables estudiades i els resultats es resumeixen en tres apartats que són els corresponents a les tres publicacions que es presenten a continuació. Al primer estudi, l’objectiu va ser estudiar els factors pronòstics de mortalitat en 235 episodis de sèpsia. Es van recollir les següents variables: edat, gènere, índex comorbiditat (Charlson), microbiologia, severitat de la infecció (APACHE-2, SIRS i quick-SOFA), dades clíniques (presentació clínica, confusió, febre o hipotensió), dades analítiques (proteïna C reactiva, procalcitonina i albúmina) i adequació del tractament antibiòtic. Vint-i-set pacients van morir als 30 dies (11,5%). Els factors relacionats amb la mortalitat van ser, l’albúmina 5 mg/dl (OR 2,03, IC 1,25-3,30; p=0,007); MEWS >3 (OR 2,11, IC 1,28-3,77; p=0,003) i l’albúmina sèrica 9 ng/L en dones i 16 ng/L en homes), va estar present a 224 pacients >65 anys (71%). Els resultats van mostrar que els pacients amb lesió miocàrdica van tenir major mortalitat intra-hospitalaria [71 (31%) vs 11 (12%); p5 mg/dL (OR 2,03, IC 1,25-3,30; p=0,007); MEWS >3 (OR 2,11, IC 1,28-3,77; p=0,003) y la albúmina sérica9 ng/L en mujeres y 16 ng/L en hombres), estuvo presente en 224 pacientes >65 años (71%). Los resultados mostraron que los pacientes con lesión miocárdica tuvieron mayor mortalidad intrahospitalaria [71 (31%) vs 11 (12%); p5 mg/dl (OR 2.03 CI 1.25-3.30; p=0.007); MEWS >3 (OR 2.11 CI 1.28-3.77; P=0.003) and serum albumin 9ng/L in women and >16 ng/L in men), was present in 224 patients >65 years (71%). The results showed that patients that presented with myocardial injury had higher in-hospital mortality [71 (31%) vs. 11 (12%); p

Published
2022

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