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1. Guideline-adherent therapy for stroke prevention in atrial fibrillation in different health care settings: Results from RAMSES study

Author

Beton, Osman, Tekinalp, Mehmet, Aykan, Ahmet Çağrı, Kalaycıoğlu, Ezgi, Bolat, Ismail, Taşar, Onur, Şafak, Özgen, Kalçık, Macit, Yaman, Mehmet, İnci, Sinan, Altıntaş, Bernas, Kalkan, Sedat, Çalık, Feyza, Karaca, Oğuz, Helvacı, Füsun, Akay, Kadriye, Çanga, Yiğit, Çelebi, Savaş, Altuntas, Emine, Aytürk, Mehmet, Güneş, Hacı Murat, Bezgin, Tahir, Aksakal, Aytekin, Çakal, Beytullah, Çolak, Ayşe, Kaplan, Özgür, Tatlısu, Adem, Gözübüyük, Gökhan, Demirelli, Selami, Kaya, Adnan, Rencüzoğulları, İbrahim, Bayram, Zübeyde, Şimşek, Zeki, Civan, Murat, Batgharel, Ulaankhu, Ata, Ali Ekber, Göl, Gökhan, Mert, Gurbet Özge, Mert, Kadir Ugur, Değirmencioğlu, Aleks, Candan, Özkan, Çelebi, Özlem Özcan, Doğan, Cem, Yavuz, Fethi, Ulucan, Şeref, Arısoy, Arif, Şahin, Bingül Dilekçi, Ermiş, Emrah, Gökaslan, Serkan, Pektaş, İdris, Tanındı, Aslı, Tekin, Kamuran, Sancar, Kadriye Memic, Çekiç, Edip Güvenç, Başaran, Nesrin Filiz, Altun, Ibrahim, Başaran, Özcan, Dogan, Volkan, Biteker, Murat, Karadeniz, Fatma Özpamuk, Tekkesin, Ahmet İlker, Çakıllı, Yasin, Türkkan, Ceyhan, Hamidi, Mehmet, Demir, Vahit, Gürsoy, Mustafa Ozan, Öztürk, Müjgan Tek, Aksan, Gökhan, Seyis, Sabri, Ballı, Mehmet, Alıcı, Mehmet Hayri, Bozyel, Serdar, and Kırma, Cevat

Published
2017
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3. Impact of valvular heart disease on oral anticoagulant therapy in non-valvular atrial fibrillation: results from the RAMSES study

Author

Başaran, Özcan, Dogan, Volkan, Beton, Osman, Tekinalp, Mehmet, Aykan, Ahmet Çağrı, Kalaycıoğlu, Ezgi, Bolat, Ismail, Taşar, Onur, Şafak, Özgen, Kalçık, Macit, Yaman, Mehmet, İnci, Sinan, Altıntaş, Bernas, Kalkan, Sedat, Kırma, Cevat, Biteker, Murat, Karadeniz, Fatma Özpamuk, Tekkesin, Ahmet İlker, Çakıllı, Yasin, Türkkan, Ceyhan, Hamidi, Mehmet, Demir, Vahit, Gürsoy, Mustafa Ozan, Öztürk, Müjgan Tek, Aksan, Gökhan, Seyis, Sabri, Ballı, Mehmet, Alıcı, Mehmet Hayri, Bozyel, Serdar, Altun, Ibrahim, Çalık, Feyza, Karaca, Oğuz, Helvacı, Füsun, Akay, Kadriye, Çanga, Yiğit, Çelebi, Savaş, Altuntas, Emine, Aytürk, Mehmet, Güneş, Hacı Murat, Bezgin, Tahir, Aksakal, Aytekin, Çakal, Beytullah, Çolak, Ayşe, Kaplan, Özgür, Tatlısu, Adem, Gözübüyük, Gökhan, Demirelli, Selami, Kaya, Adnan, Rencüzoğulları, İbrahim, Bayram, Zübeyde, Şimşek, Zeki, Civan, Murat, Batgharel, Ulaankhu, Ata, Ali Ekber, Göl, Gökhan, Mert, Gurbet Özge, Mert, Kadir Ugur, Değirmencioğlu, Aleks, Candan, Özkan, Çelebi, Özlem Özcan, Doğan, Cem, Yavuz, Fethi, Ulucan, Şeref, Arısoy, Arif, Şahin, Bingül Dilekçi, Ermiş, Emrah, Gökaslan, Serkan, Pektaş, İdris, Tanındı, Aslı, Tekin, Kamuran, Sancar, Kadriye Memic, Çekiç, Edip Güvenç, Başaran, Nesrin Filiz, and and Collaborators

Published
2017
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12. Analysis of geographical variations in the epidemiology and management of non-valvular atrial fibrillation: results from the RAMSES registry

Author

Arısoy, Arif, Yavuz, Fethi, Bozyel, Serdar, Alıcı, Mehmet Hayri, Ballı, Mehmet, Seyis, Sabri, Tekkesin, Ahmet İlker, Çakıllı, Yasin, Türkkan, Ceyhan, Demir, Vahit, Çalık, Feyza, Karaca, Oğuz, Başaran, Nesrin Filiz, Çekiç, Edip Güvenç, Altun, İbrahim, Helvacı, Füsun, Aytürk, Mehmet, Akay, Kadriye, Çanga, Yiğit, Çelebi, Savaş, Altuntaş, Emine, Güneş, Hacı Murat, Bezgin, Tahir, Aksakal, Aytekin, Çakal, Beytullah, Memic Sancar, Kadriye, Çolak, AYŞE, Kaplan, Özgür, Tatlısu, Adem, Gözübüyük, Gökhan, Demirelli, Selami, Kaya, Adnan, Rencüzoğulları, İbrahim, Bayram, Zübeyde, Şimşek, Zeki, Civan, Murat, Batgharel, Ulaankhu, Başaran, Özcan, Biteker, Murat, Özpamuk Karadeniz, Fatma, Ermiş, Emrah, Dilekçi Şahin, Bingül, Ulucan, Şeref, Ata, Ali Ekber, Göl, Gökhan, Mert, Gurbet Özge, Kırma, Cevat, Aksan, Gökhan, Kalkan, Sedat, Tek Öztürk, Müjgan, Mert, Kadir Uğur, Gürsoy, Mustafa Ozan, Hamidi, Mehmet, Değirmencioğlu, Aleks, Tekin, Kamuran, Tanındı, Aslı, Pektaş, İdris, Gökaslan, Serkan, Candan, Özkan, Özcan Çelebi, Özlem, Doğan, Cem, Doğan, Volkan, Balıkesir Üniversitesi, MÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Doğan, Volkan, Başaran, Özcan, Biteker, Murat, TOBB ETU, Faculty of Medicine, Department of Internal Medical Sciences, TOBB ETÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, and Çelebi, Aksüyek Savaş

Subjects
Male, Turkish population, medicine.medical_specialty, Turkey, Epidemiology, Anticoagulant Therapy, Kalp ve Kalp Damar Sistemi, Non valvular atrial fibrillation, 030204 cardiovascular system & hematology, 03 medical and health sciences, 0302 clinical medicine, Risk Factors, Atrial Fibrillation, medicine, Humans, Black sea, 030212 general & internal medicine, Registries, Stroke, Aged, Demography, Original Investigation, Antithrombotic therapy, anticoagulant therapy, business.industry, Anticoagulants, medicine.disease, Socioeconomic Factors, Stroke prevention, Chronic Disease, Physical therapy, Observational study, Residence, Female, epidemiology, Cardiology and Cardiovascular Medicine, business, chronic disease
Abstract

Hamidi, Mehmet (Balikesir Author), Objective: This study aimed to determine the differences in terms of demographic characteristics and preferred stroke prevention strategies for patients with non-valvular atrial fibrillation living in seven geographical regions of Turkey.Methods: In total, 6273 patients were enrolled to this prospective, observational RAMSES study. The patients were divided into seven groups based on the geographical region of residence.Results: In terms of the geographical distribution of the overall Turkish population, the highest number of patients were enrolled from Marmara (1677, 26.7%). All demographic characteristics were significantly different among regions. Preferred oral anticoagulants (OACs) also differed between geographical regions; non-vitamin K OACs were preceded by warfarin in East Anatolia, Aegean, Southeast Anatolia, and Black Sea. Nearly one-third of the patients (28%) did not receive any OAC therapy. However, the number of patients not receiving any OAC therapy was higher in Southeast Anatolia (51.1%) and East Anatolia (46.8%) compared with other geographical regions of Turkey. Inappropriate use of OACs was also more common in East and Southeast Anatolia.Conclusion: This study was the first to show that the demographic differences among the geographical regions may result in different preferences of stroke prevention strategies in Turkey. OACs are still under- or inappropriately utilized, particularly in the eastern provinces of Turkey.

Published
2017

13. Real-world stroke prevention strategies in nonvalvular atrial fibrillation in patients with renal impairment

Author

Alici, Hayri, Soylu, Özcan, Altun, Ibrahim, Başaran, Filiz, Çekiç, Güvenç, Sancar, Memic, Tekin, Kamuran, Tanındı, Aslı, Pektaş, İdris, Gökaslan, Serkan, Ermiş, Emrah, Şahin, Dilekçi, Arısoy, Arif, Ulucan, Şeref, Yavuz, Fethi, Doğan, Cem, Çelebi, Özcan, Candan, Özkan, Değirmencioğlu, Aleks, Göl, Gökhan, Ata, Ekber, Batgharel, Ulaankhu, Civan, Murat, Şimşek, Zeki, Bayram, Zübeyde, Rencüzoğulları, İbrahim, Kaya, Adnan, Demirelli, Selami, Gözübüyük, Gökhan, Tatlısu, Adem, Kaplan, Özgür, Çolak, AYŞE, Çakal, Beytullah, Aksakal, Aytekin, Bezgin, Tahir, Mert, Kadir U, Mert, Gurbet Ö, Başaran, Özcan, Beton, Osman, Dogan, Volkan, Tekinalp, Mehmet, Aykan, Ahmet Ç, Kalaycıoğlu, Ezgi, Bolat, Ismail, Taşar, Onur, Şafak, Özgen, Kalçık, Macit, Yaman, Mehmet, Kırma, Cevat, Biteker, Murat, İnci, Sinan, Altıntaş, Bernas, Kalkan, Sedat, Karadeniz, Özpamuk, Tekkesin, İlker, Çakıllı, Yasin, Türkkan, Ceyhan, Hamidi, Mehmet, Demir, Vahit, Gürsoy, Ozan, Öztürk, Tek, Aksan, Gökhan, Seyis, Sabri, Ballı, Mehmet, Bozyel, Serdar, Çalık, Feyza, Karaca, Oğuz, Helvacı, Füsun, Akay, Kadriye, Çanga, Yiğit, Çelebi, Savaş, Altuntas, Emine, Aytürk, Mehmet, Güneş, Murat, [Mert, Kadir U.] Eskiehir Osmangazi Univ, Dept Cardiol, Fac Med, Eskisehir, Turkey -- [Mert, Gurbet O.] Eskisehir Yunus Emre State Hosp, Dept Cardiol, Eskisehir, Turkey -- [Basaran, Ozcan -- Dogan, Volkan -- Biteker, Murat] Mugla Sitki Kocman Univ, Dept Cardiol, Fac Med, Mugla, Turkey -- [Beton, Osman] Sivas Cumhuriyet Univ, Dept Cardiol, Fac Med, Sivas, Turkey -- [Tekinalp, Mehmet] Kahramanmaras Necip Fazil State Hosp, Dept Cardiol, Kahramanmaras, Turkey -- [Aykan, Ahmet C. -- Kalaycioglu, Ezgi] Trabzon Ahi Evren Chest Cardiovasc Surg Educ & Re, Dept Cardiol, Trabzon, Turkey -- [Bolat, Ismail] Fethiye State Hosp, Dept Cardiol, Mugla, Turkey -- [Tasar, Onur] Elazig Educ & Res Hosp, Dept Cardiol, Elazig, Turkey -- [Safak, Ozgen] Burdur State Hosp, Dept Cardiol, Burdur, Turkey -- [Kalcik, Macit] Iskilip Atif Hoca State Hosp, Dept Cardiol, Corum, Turkey -- [Yaman, Mehmet] Samsun Educ & Res Hosp, Dept Cardiol, Samsun, Turkey -- [Kirma, Cevat] Kartal Kosuyolu Heart Educ & Res Hosp, Istanbul, Turkey, BASARAN, OZCAN -- 0000-0002-6384-6455, Demir, Vahit -- 0000-0001-8349-6651, and mert, kadir ugur -- 0000-0002-1331-5365

Subjects
renal impairment, Male, medicine.medical_specialty, Clinical Biochemistry, Renal function, Administration, Oral, 030204 cardiovascular system & hematology, Biochemistry, 03 medical and health sciences, Pulmonary Disease, Chronic Obstructive, 0302 clinical medicine, prevention, Fibrinolytic Agents, Internal medicine, Atrial Fibrillation, Medicine, Humans, In patient, Atrium fibrillation, 030212 general & internal medicine, Prospective Studies, Registries, Renal Insufficiency, Chronic, Stroke, Aged, glomerular filtration rate, business.industry, Anticoagulants, Atrial fibrillation, General Medicine, Baseline data, medicine.disease, stroke, Stroke prevention, Concomitant, Cardiology, Population study, Female, business, Platelet Aggregation Inhibitors, Glomerular Filtration Rate
Abstract

WOS: 000402283900004, PubMed ID: 28407216, BackgroundThe data regarding stroke prevention strategies in nonvalvular atrial fibrillation (NVAF) are limited especially in patients with renal impairment (RI). We sought to evaluate management dilemmas in patients with concurrent NVAF and RI in RAMSES (ReAl-life Multicenter Survey Evaluating Stroke Prevention Strategies inTurkey) study. MethodsWe conducted a prospective, multicenter, nation-wide registry in NVAF patients in outpatient cardiology clinics. All consecutive patients with NVAF were enrolled in RAMSES study (ClinicalTrials.gov identifier NCT02344901). The baseline data were collected. Glomerular filtration rate (GFR) was estimated by Cockcroft-Gault equation. ResultsA total number of 6273 patients from 29 provinces of Turkey with the contribution of 83 investigators were enrolled to the study. Of the study population, 1964(33%) patients had RI which was defined as GFR < 60 mL/min. Patients with RI had significantly higher CHA(2)DS(2)VASc and HAS-BLED scores compared to those without RI (39 15 vs. 29 +/- 15, and 20 +/- 1 vs. 14 +/- 1; P < 0001). Prior history of major bleeding (69% vs. 41%, P < 0001) and stroke (162% vs. 118%, P < 0001) was significantly higher among individuals with concomitant RI and NVAF. Although RI patients had a higher risk for thromboembolism, number of the patients who did not receive any anticoagulant therapy was higher in patients with RI than without RI (301 vs. 264%, P = 0003). ConclusionRAMSES study showed that one-third of the patients with NVAF had RI in the real-world setting. Although it is mandatory in most of the patients with concomitant NVAF and RI, nearly one-third of these patients did not receive any anticoagulant therapy.

Published
2017

14. Impact of valvular heart disease on oral anticoagulant therapy in non-valvular atrial fibrillation: results from the RAMSES study

Author

Tekkesin, Ahmet İlker, Öztürk, Müjgan Tek, Gürsoy, Mustafa Ozan, Demir, Vahit, Hamidi, Mehmet, Türkkan, Ceyhan, Çakıllı, Yasin, Karadeniz, Fatma Özpamuk, Biteker, Murat, Kırma, Cevat, Kalkan, Sedat, Altıntaş, Bernas, İnci, Sinan, Yaman, Mehmet, Kalçık, Macit, Şafak, Özgen, Taşar, Onur, Bolat, Ismail, Kalaycıoğlu, Ezgi, Aykan, Ahmet Çağrı, Tekinalp, Mehmet, Beton, Osman, Dogan, Volkan, Başaran, Özcan, Başaran, Nesrin Filiz, Çekiç, Edip Güvenç, Sancar, Kadriye Memic, Tekin, Kamuran, Tanındı, Aslı, Pektaş, İdris, Gökaslan, Serkan, Ermiş, Emrah, Şahin, Bingül Dilekçi, Arısoy, Arif, Ulucan, Şeref, Yavuz, Fethi, Doğan, Cem, Çelebi, Özlem Özcan, Candan, Özkan, Değirmencioğlu, Aleks, Mert, Kadir Ugur, Mert, Gurbet Özge, Göl, Gökhan, Ata, Ali Ekber, Batgharel, Ulaankhu, Civan, Murat, Şimşek, Zeki, Bayram, Zübeyde, Rencüzoğulları, İbrahim, Kaya, Adnan, Demirelli, Selami, Gözübüyük, Gökhan, Tatlısu, Adem, Kaplan, Özgür, Çolak, AYŞE, Çakal, Beytullah, Aksakal, Aytekin, Bezgin, Tahir, Güneş, Hacı Murat, Aytürk, Mehmet, Altuntas, Emine, Çelebi, Savaş, Çanga, Yiğit, Akay, Kadriye, Helvacı, Füsun, Karaca, Oğuz, Çalık, Feyza, Altun, Ibrahim, Bozyel, Serdar, Alıcı, Mehmet Hayri, Ballı, Mehmet, Seyis, Sabri, Aksan, Gökhan, [Basaran, Ozcan -- Dogan, Volkan -- Biteker, Murat] Mugla Sitki Kocman Univ, Dept Cardiol, Fac Med, Tip Fak, Orhaniye Mah Haluk Ozsoy Cad, Mugla, Turkey -- [Beton, Osman] Sivas Cumhuriyet Univ, Dept Cardiol, Fac Med, Sivas, Turkey -- [Tekinalp, Mehmet] Kahramanmaras Necip Fazil State Hosp, Dept Cardiol, Kahramanmaras, Turkey -- [Aykan, Ahmet Cagri -- Kalaycioglu, Ezgi] Trabzon Ahi Evren Chest Cardiovasc Surg Educ & Re, Dept Cardiol, Trabzon, Turkey -- [Bolat, Ismail] Fethiye State Hosp, Dept Cardiol, Mugla, Turkey -- [Tasar, Onur] Elazig Educ & Res Hosp, Dept Cardiol, Elazig, Turkey -- [Safak, Ozgen] Burdur State Hosp, Dept Cardiol, Burdur, Turkey -- [Kalcik, Macit] Iskilip Atif Hoca State Hosp, Dept Cardiol, Iskilip, Turkey -- [Yaman, Mehmet] Samsun Educ & Res Hosp, Dept Cardiol, Samsun, Turkey -- [Inci, Sinan] Aksaray State Hosp, Dept Cardiol, Aksaray, Turkey -- [Altintas, Bernas] Diyarbakir Gazi Yasargil Educ & Res Hosp, Dept Cardiol, Diyarbakir, Turkey -- [Kalkan, Sedat] Gonen State Hosp, Dept Cardiol, Gonen, Turkey -- [Kirma, Cevat] Kartal Kosuyolu Heart Educ & Res Hosp, Istanbul, Turkey, BASARAN, OZCAN -- 0000-0002-6384-6455, Demir, Vahit -- 0000-0001-8349-6651, Tıp Fakültesi, MÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Başaran, Özcan, Doğan, Volkan, and Biteker, Murat

Subjects
Male, medicine.medical_specialty, Aortic Valve Insufficiency, Heart Valve Diseases, Administration, Oral, Hemorrhage, Regurgitation (circulation), 030204 cardiovascular system & hematology, Non-valvular Atrial Fibrillation, Non-valvular atrial fibrillation, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Atrial Fibrillation, medicine, Humans, Oral Anticoagulant Therapy, cardiovascular diseases, 030212 general & internal medicine, Practice Patterns, Physicians', Stroke, Mitral regurgitation, Hematology, business.industry, ComputerSystemsOrganization_COMPUTER-COMMUNICATIONNETWORKS, valvular heart disease, Anticoagulants, Mitral Valve Insufficiency, Atrial fibrillation, Middle Aged, medicine.disease, Valvular heart disease, Surgery, ComputingMilieux_MANAGEMENTOFCOMPUTINGANDINFORMATIONSYSTEMS, Stenosis, Cross-Sectional Studies, ComputingMethodologies_PATTERNRECOGNITION, Valvular Heart Disease, cardiovascular system, Cardiology, Oral anticoagulant therapy, Population study, Female, InformationSystems_MISCELLANEOUS, Cardiology and Cardiovascular Medicine, business
Abstract

WOS: 000394997800003, PubMed ID: 27848065, The definition of non-valvular atrial fibrillation (NVAF) is controversial. We aimed to assess the impact of valvular heart disease on stroke prevention strategies in NVAF patients. The RAMSES study was a multicenter and cross-sectional study conducted on NVAF patients (ClinicalTrials.gov identifier NCT02344901). The study population was divided into patients with significant valvular disease (SVD) and non-significant valvular disease (NSVD), whether they had at least one moderate valvular disease or not. Patients with a mechanical prosthetic valve and mitral stenosis were excluded. Baseline characteristics and oral anticoagulant (OAC) therapies were compared. In 5987 patients with NVAF, there were 3929 (66%) NSVD and 2058 (34%) SVD patients. The predominant valvular disease was mitral regurgitation (58.1%), followed by aortic regurgitation (24.1%) and aortic stenosis (17.8%). Patients with SVD had higher CHA(2)DS(2)VASc [3.0 (2.0; 4.0) vs. 4.0 (2.0; 5.0), p < 0.001] and HAS-BLED [2.0 (1.0; 2.0) vs. 2.0 (1.0; 2.0), p = 0.004] scores compared to patients with NSVD. Overall, 2763 (71.2%) of NSVD and 1515 (73.8%) of SVD patients were on OAC therapy (p = 0.035). When the patients with SVD were analyzed separately, the mean CHA(2)DS(2)VASc and HAS-BLED scores were higher in patients with mitral regurgitation compared to patients with aortic regurgitation and aortic stenosis [4.0 (3.0; 5.0), 3.0 (2.0; 4.0), 3.0 (2.0; 4.0) p < 0.001 and 2.0 (1.0; 3.0), 1.0 (1.0; 2.0), 1.0 (0.0; 2.0) p < 0.001, respectively]. In patients with SVD, 65.7% of mitral regurgitation, 82.6% of aortic regurgitation and 88.0% of aortic stenosis patients were on OAC therapy. One out of three NVAF patients had at least one moderate valvular heart disease with the predominance of mitral regurgitation. Patients with SVD were at greater risk of stroke and bleeding compared to patients with NSVD. Although patients with mitral regurgitation should be given more aggressive anticoagulant therapy due to their higher risk of stroke, they are undertreated compared to patients with aortic valve diseases.

Published
2017

15. Rationale, design and methodology of the RAMSES Study: ReAl-life Multicenter Survey Evaluating Stroke Prevention Strategies

Author

Pekel, Nihat, Başaran, Özcan, Doğan, Volkan, Memic Sancar, Kadriye, Altun, İbrahim, Mert, Kadir Uğur, Mert, Gurbet Özge, Başaran, Nesrin Filiz, Çekiç, Edip Güvenç, Kırma, Cevat, Biteker, Murat, Beton, Osman, Tekinalp, Mehmet, Aykan, AhmetÇağrı, Kalaycıoğlu, Ezgi, Bolat, Ismail, Taşar, Onur, Şafak, Özgen, Kalçık, Macit, Yaman, Mehmet, İnci, Sinan, Altıntaş, Berna, Kalkan, Sedat, Özpamuk Karadeniz, Fatma, Tekkesin, Ahmetİlker, Çakıllı, Yasin, Türkkan, Ceyhan, Hamidi, Mehmet, Demir, Vahit, Gürsoy, MustafaOzan, Tek Öztürk, Müjgan, Aksan, Gökhan, Seyis, Sabri, Ballı, Mehmet, Alıcı, MehmetHayri, Bozyel, Serdar, Çalık, Feyza, Karaca, Oğuz, Helvacı, Füsun, Akay, Kadriye, Çanga, Yiğit, Çelebi, Savaş, Altuntas, Emine, Aytürk, Mehmet, Güneş, HacıMurat, Bezgin, Tahir, Aksakal, Aytekin, Çakal, Beytullah, Çolak, AYŞE, Kaplan, Özgür, Tatlısu, Adem, Gözübüyük, Gökhan, Demirelli, Selami, Kaya, Adnan, Rencüzoğulları, İbrahim, Bayram, Zübeyde, Şimşek, Zeki, Civan, Murat, Batgharel, Ulaankhu, Ata, AliEkber, Göl, Gökhan, Değirmencioğlu, Aleks, Candan, Özkan, Özcan Çelebi, Özlem, Doğan, Cem, Yavuz, Fethi, Ulucan, Şeref, Arısoy, Arif, Dilekçi Şahin, Bingül, Ermiş, Emrah, Gökaslan, Serkan, Pektaş, İdris, Tanındı, Aslı, Tekin, Kamuran, Bilal Karaayvaz, Ekrem, Koc, Mevlut, Şahin, DurmusYıldıray, Çimen, Tolga, Güvenç, TolgaSinan, Temel, Kerem, Keskin, Vehip, Soylu, MustafaÖzcan, Akın, Fatih, MÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Başaran, Özcan, Doğan, Volkan, Sancar, Kadriye Memic, Altun, İbrahim, Mert, Kadir Ugur, and Mert, Gurbet Ozge

Subjects
lcsh:Internal medicine, lcsh:Diseases of the circulatory (Cardiovascular) system, medicine.medical_specialty, Turkey, Administration, Oral, lcsh:Medicine, 030204 cardiovascular system & hematology, 03 medical and health sciences, 0302 clinical medicine, Atrial Fibrillation, Antithrombotic, medicine, Humans, atrial fibrillation, Prospective Studies, 030212 general & internal medicine, lcsh:RC31-1245, Prospective cohort study, oral anticoagulant, risk scores, stroke, turkey, business.industry, lcsh:R, Anticoagulants, Atrial fibrillation, Risk Scores, medicine.disease, Stroke, Anticoagulant therapy, lcsh:RC666-701, Epidemiologic Research Design, Baseline characteristics, Stroke prevention, Emergency medicine, Multicenter survey, Observational study, Oral Anticoagulant, Cardiology and Cardiovascular Medicine, business
Abstract

WOS: 000375095000005 PubMed ID: 27138310 Objective: Atrial fibrillation is the most common arrhythmia and is associated with a five-fold increased risk of thromboembolic events. Vitamin K antagonists (VKAs) have been the mainstay of oral anticoagulant prophylaxis and the data on stroke prevention strategies are limited to VKA era. The purpose of this study is to evaluate the use of VKA, non-Vitamin K antagonist oral anticoagulants (NOAC), and antiplatelet agents in patients with non-valvular atrial fibrillation (NVAF). Methods: The ReAl-life Multicenter Survey Evaluating Stroke prevention strategies in Turkey (RAMSES) is an observational, multicenter, prospective study of patients with NVAF. The study targeted enrollment of 7835 patients from 68 sites in Turkey. All the data will be collected at one point in time and current clinical practice will be evaluated. (ClinicalTrials.gov number NCT02344901). Results: Baseline characteristics of patients, antithrombotic therapies, transition to NOACs and rate/rhythm control strategies will be evaluated. Conclusion: The RAMSES registry will be the largest study in Turkish NVAF patients. The study will provide insights into real-world problems and anticoagulant treatment in patients with NVAF.

Published
2016

17. Guideline-adherent therapy for stroke prevention in atrial fibrillation in different health care settings: Results from RAMSES study

Author

Başaran, Özcan, primary, Dogan, Volkan, additional, Biteker, Murat, additional, Karadeniz, Fatma Özpamuk, additional, Tekkesin, Ahmet İlker, additional, Çakıllı, Yasin, additional, Türkkan, Ceyhan, additional, Hamidi, Mehmet, additional, Demir, Vahit, additional, Gürsoy, Mustafa Ozan, additional, Öztürk, Müjgan Tek, additional, Aksan, Gökhan, additional, Seyis, Sabri, additional, Ballı, Mehmet, additional, Alıcı, Mehmet Hayri, additional, Bozyel, Serdar, additional, Kırma, Cevat, additional, Beton, Osman, additional, Tekinalp, Mehmet, additional, Aykan, Ahmet Çağrı, additional, Kalaycıoğlu, Ezgi, additional, Bolat, Ismail, additional, Taşar, Onur, additional, Şafak, Özgen, additional, Kalçık, Macit, additional, Yaman, Mehmet, additional, İnci, Sinan, additional, Altıntaş, Bernas, additional, Kalkan, Sedat, additional, Çalık, Feyza, additional, Karaca, Oğuz, additional, Helvacı, Füsun, additional, Akay, Kadriye, additional, Çanga, Yiğit, additional, Çelebi, Savaş, additional, Altuntas, Emine, additional, Aytürk, Mehmet, additional, Güneş, Hacı Murat, additional, Bezgin, Tahir, additional, Aksakal, Aytekin, additional, Çakal, Beytullah, additional, Çolak, Ayşe, additional, Kaplan, Özgür, additional, Tatlısu, Adem, additional, Gözübüyük, Gökhan, additional, Demirelli, Selami, additional, Kaya, Adnan, additional, Rencüzoğulları, İbrahim, additional, Bayram, Zübeyde, additional, Şimşek, Zeki, additional, Civan, Murat, additional, Batgharel, Ulaankhu, additional, Ata, Ali Ekber, additional, Göl, Gökhan, additional, Mert, Gurbet Özge, additional, Mert, Kadir Ugur, additional, Değirmencioğlu, Aleks, additional, Candan, Özkan, additional, Çelebi, Özlem Özcan, additional, Doğan, Cem, additional, Yavuz, Fethi, additional, Ulucan, Şeref, additional, Arısoy, Arif, additional, Şahin, Bingül Dilekçi, additional, Ermiş, Emrah, additional, Gökaslan, Serkan, additional, Pektaş, İdris, additional, Tanındı, Aslı, additional, Tekin, Kamuran, additional, Sancar, Kadriye Memic, additional, Çekiç, Edip Güvenç, additional, Başaran, Nesrin Filiz, additional, and Altun, Ibrahim, additional

Published
2017
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20. Mean Platelet Volume Associated with Aortic Distensibility, Chronic Inflammation and Diabetes in Patients with Stable Coronary Artery Disease

Author

Şahin, Durmuş Yıldıray, primary, Gür, Mustafa, additional, Elbasan, Zafer, additional, Yıldırım, Arafat, additional, Akıllı, Rabia Eker, additional, Koyunsever, Nermin Yıldız, additional, Özaltun, Betül, additional, Gözübüyük, Gökhan, additional, Kıvrak, Ali, additional, and Çaylı, Murat, additional

Published
2013
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22. SYNTAX Score is a Predictor of Angiographic No-Reflow in Patients with ST Elevation Myocardial Infarction Treated with Primary Percutaneous Coronary Intervention

Author

Şahin, Durmuş Yıldıray, primary, Gür, Mustafa, additional, Elbasan, Zafer, additional, Kuloğlu, Osman, additional, Şeker, Taner, additional, Kıvrak, Ali, additional, Tanboğa, İbrahim Halil, additional, Gözübüyük, Gökhan, additional, Kırım, Sinan, additional, and Çaylı, Murat, additional

Published
2013
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23. Myocardial Performance Index and Aortic Distensibility in Patients with Different Left Ventricle Geometry in Newly Diagnosed Essential Hypertension

Author

Şahin, Durmuş Yıldıray, primary, Gür, Mustafa, additional, Elbasan, Zafer, additional, Kalkan, Gülhan Yüksel, additional, Özdoğru, İbrahim, additional, Kıvrak, Ali, additional, Gözübüyük, Gökhan, additional, Kuloğlu, Osman, additional, Sümbül, Zehra, additional, and Çaylı, Murat, additional

Published
2013
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24. N Terminal pro-Brain Natriuretic Peptide Level is Associated with SYNTAX Score and Aortic Distensibility in Patients with Stable Coronary Artery Disease

Author

Şahin, Durmuş Yıldıray, primary, Gür, Mustafa, additional, Elbasan, Zafer, additional, Koyunsever, Nermin Yıldız, additional, Türkoğlu, Caner, additional, Akyol, Selahattin, additional, Yıldırım, Arafat, additional, Gözübüyük, Gökhan, additional, Özaltun, Betül, additional, and Çaylı, Murat, additional

Published
2013
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25. Aortic Distensibility and Aortic Intima-Media Thickness in Patients without Clinical Manifestation of Atherosclerotic Cardiovascular Disease

Author

Elbasan, Zafer, primary, Şahin, Durmuş Yıldıray, additional, Gür, Mustafa, additional, Kalkan, Gülhan Yüksel, additional, Yıldız, Ali, additional, Kaya, Zekeriya, additional, Kıvrak, Ali, additional, Gözübüyük, Gökhan, additional, Özdoğru, İbrahim, additional, and Çaylı, Murat, additional

Published
2013
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27. Myocardial performance index and aortic distensibility in patients with different left ventricle geometry in newly diagnosed essential hypertension

Author

Şahіn, Durmuş Yildiray, primary, Gür, Mustafa, additional, Elbasan, Zafer, additional, Kalkan, Gülhan Yüksel, additional, Özdoğru, İbrahіm, additional, Kivrak, Alі, additional, Gözübüyük, Gökhan, additional, Kuloğlu, Osman, additional, Sümbül, Zehra, additional, and Çayli, Murat, additional

Published
2013
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28. SYNTAX score is a predictor of angiographic no-reflow in patients with ST-elevation myocardial infarction treated with a primary percutaneous coronary intervention

Author

Şahin, Durmuş Y., primary, Gür, Mustafa, additional, Elbasan, Zafer, additional, Kuloğlu, Osman, additional, Şeker, Taner, additional, Kivrak, Ali, additional, Tanboğa, İbrahim H., additional, Gözübüyük, Gökhan, additional, Kirim, Sinan, additional, and Çayli, Murat, additional

Published
2013
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29. Aortic Distensibility and Extent and Complexity of Coronary Artery Disease in Patients with Stable Hypertensive and Nonhypertensive Coronary Artery Disease

Author

Elbasan, Zafer, primary, Şahin, DurmuşYıldıray, additional, Gür, Mustafa, additional, Gözübüyük, Gökhan, additional, Akıllı, Rabia Eker, additional, Koyunsever, Nermin Yıldız, additional, Türkoğlu, Caner, additional, Kıvrak, Ali, additional, Yıldırım, Arafat, additional, and Çaylı, Murat, additional

Published
2013
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30. Mean Platelet Volume Associated With Aortic Distensibility, Chronic Inflammation, and Diabetes in Patients With Stable Coronary Artery Disease

Author

Şahin, Durmuş Yıldıray, primary, Gür, Mustafa, additional, Elbasan, Zafer, additional, Yıldırım, Arafat, additional, Akıllı, Rabia Eker, additional, Koyunsever, Nermin Yıldız, additional, Özaltun, Betül, additional, Gözübüyük, Gökhan, additional, Kıvrak, Ali, additional, and Çaylı, Murat, additional

Published
2012
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31. Mean Platelet Volume and Extent and Complexity of Coronary Artery Disease in Diabetic and Nondiabetic Patients With ST Elevation Myocardial Infarction

Author

Şahin, Durmuş Yıldıray, primary, Gür, Mustafa, additional, Elbasan, Zafer, additional, Özdoğru, İbrahim, additional, Uysal, Onur Kadir, additional, Kıvrak, Ali, additional, Gözübüyük, Gökhan, additional, Türkoğlu, Caner, additional, Özkan, Buğra, additional, and Çaylı, Murat, additional

Published
2012
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32. Predictive role of left atrial and ventricular mechanical function in postoperative atrial fibrillation: a two-dimensional speckle-tracking echocardiography study.

Author

Başaran, Özcan, Tigen, Kürşat, Gözübüyük, Gökhan, Dündar, Cihan, Güler, Ahmet, Taşar, Onur, Biteker, Murat, Karabay, Can Yücel, Bulut, Mustafa, Karaahmet, Tansu, and Kırma, Cevat

Abstract

Copyright of Archives of the Turkish Society of Cardiology / Türk Kardiyoloji Derneği Arşivi is the property of KARE Publishing and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2016
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33. SYNTAX score is a predictor of angiographic no-reflow in patients with ST-elevation myocardial infarction treated with a primary percutaneous coronary intervention

Author

ahin, Durmu Y., Gür, Mustafa, Elbasan, Zafer, Kulolu, Osman, eker, Taner, Kivrak, Ali, Tanboa, brahim H., Gözübüyük, Gökhan, Kirim, Sinan, and Çayli, Murat

Abstract

The no-reflow phenomenon has a negative prognostic value in patients with acute ST-elevation myocardial infarction (STEMI). The SYNTAX score (SS) quantifies the extent and complexity of angiographic disease and predicts long-term mortality and morbidity in STEMI. We aimed to assess the no-reflow and its possible relationships with SS and clinical characteristics in patients with STEMI treated with a primary percutaneous coronary intervention (PPCI).

Published
2013
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34. Severe tricuspid stenosis caused by myxoma originated from septal leaflet of tricuspid valve.

Author

Can, Mehmet, Tanboğa, İbrahim, Gözübüyük, Gökhan, Akgün, Taylan, Türkyılmaz, Erdem, Oduncu, Vecih, and Kaymaz, Cihangir

Subjects
SYMPTOMS, DYSPNEA, PALPITATION, TRICUSPID valve surgery, CARDIAC surgery, MEDICAL imaging systems
Abstract

The article presents a case study of a 26-year old man with progressive symptoms of dyspnea and palpitation. He has no history of any diseases, while his electrocardiography, telecardiography and laboratory values were all normal. However, the result of his transthoracic echocardiography revealed a mass on the atrial side of his right heart which originates from the septal leaflet of the tricuspid valve. As a result, he undergone open-heart surgery and successful tricuspid valve repair.

Published
2009

35. Predictive role of left atrial and ventricular mechanical function in postoperative atrial fibrillation: a two-dimensional speckle-tracking echocardiography study.

Author

Başaran Ö, Tigen K, Gözübüyük G, Dündar C, Güler A, Taşar O, Biteker M, Karabay CY, Bulut M, Karaahmet T, and Kırma C

Subjects
Adrenergic beta-Antagonists, Aged, Atrial Fibrillation diagnosis, Coronary Artery Bypass adverse effects, Coronary Artery Disease surgery, Echocardiography, Female, Heart Atria physiopathology, Heart Ventricles physiopathology, Humans, Male, Middle Aged, Natriuretic Peptide, Brain blood, Peptide Fragments blood, Postoperative Complications diagnosis, Predictive Value of Tests, Prospective Studies, Atrial Fibrillation epidemiology, Atrial Fibrillation physiopathology, Atrial Function, Left physiology, Heart Atria diagnostic imaging, Heart Ventricles diagnostic imaging, Postoperative Complications epidemiology, Postoperative Complications physiopathology
Abstract

Objective: The aim of this study was to determine the role of left-sided mechanical parameters in postoperative atrial fibrillation (POAF) in patients undergoing coronary artery bypass grafting (CABG)., Methods: Ninety patients with coronary artery disease and normal left ventricular (LV) function in sinus rhythm were enrolled in the study. Preoperative LV and left atrial (LA) mechanics were evaluated by two-dimensional (2D) speckle-tracking echocardiography (STE), including strain and rotation parameters, and volume indices. Patients were monitored in order to detect POAF during the postoperative period., Results: Twenty-three of 90 patients (25.6%) developed POAF. Age (p<0.001) and preoperative beta blocker usage (p=0.001) were the clinical parameters associated with POAF. Left atrial maximum volume index (LAV[max]i) increased, and peak left atrial longitudinal strain (PALS) was impaired in POAF patients (p=0.001, p<0.001, respectively). Left ventricular twist (LVtw) and left ventricular peak untwisting velocity (UntwV) were augmented in POAF patients (p=0.013, p=0.009, respectively). Receiver operating characteristic analysis showed N-terminal pro-brain natriuretic peptide (NT-proBNP) levels above 70 pg/ml and predicted POAF with a sensitivity of 74% and specificity of 78% (area under curve: 0.758, 95% confidence interval [CI] 0.631-0.894, p<0.001). Logistic regression analysis demonstrated that age (odds ratio [OR] 1.1, CI 1.01-1.20, p=0.034), preoperative beta blocker usage (OR 8.84, CI 1.36-57.28, p=0.022), NT-proBNP (values >70 pg/ml, OR 22.377, CI 3.286-152.381, p<0.001), PALS (OR 0.86, CI 0.75-0.98, p=0.023), and UntwV (OR 1.02, CI 1.00-1.04, p=0.029) were the independent predictors of POAF., Conclusion: The combination of 2D STE, clinical, and biochemical parameters may help predict POAF.

Published
2016
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36. Intermittent severe tricuspid stenosis caused by myxoma originating from the free wall of the right atrium.

Author

Can MM, Tanboğa IH, Gözübüyük G, and Kaymaz C

Subjects
Aged, Heart Neoplasms diagnostic imaging, Heart Neoplasms surgery, Humans, Male, Myxoma diagnostic imaging, Myxoma surgery, Treatment Outcome, Tricuspid Valve Stenosis diagnostic imaging, Tricuspid Valve Stenosis surgery, Ultrasonography, Heart Neoplasms complications, Myxoma complications, Tricuspid Valve Stenosis etiology
Published
2010

37. Severe tricuspid stenosis caused by myxoma originated from septal leaflet of tricuspid valve.

Author

Can M, Tanboğa I, Gözübüyük G, Akgün T, Türkyilmaz E, Oduncu V, and Kaymaz C

Subjects
Adult, Heart Neoplasms complications, Heart Neoplasms surgery, Humans, Male, Myxoma complications, Myxoma surgery, Ultrasonography, Heart Neoplasms diagnostic imaging, Myxoma diagnostic imaging, Tricuspid Valve surgery, Tricuspid Valve Stenosis etiology
Published
2009

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