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23 results on '"Götze, Tom"'

1. Factor XII signaling via uPAR-integrin β1 axis promotes tubular senescence in diabetic kidney disease

Author

Elwakiel, Ahmed, Gupta, Dheerendra, Rana, Rajiv, Manoharan, Jayakumar, Al-Dabet, Moh’d Mohanad, Ambreen, Saira, Fatima, Sameen, Zimmermann, Silke, Mathew, Akash, Li, Zhiyang, Singh, Kunal, Gupta, Anubhuti, Pal, Surinder, Sulaj, Alba, Kopf, Stefan, Schwab, Constantin, Baber, Ronny, Geffers, Robert, Götze, Tom, Alo, Bekas, Lamers, Christina, Kluge, Paul, Kuenze, Georg, Kohli, Shrey, Renné, Thomas, Shahzad, Khurrum, and Isermann, Berend

Published
2024
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3. Bipyraloxifene – a modified raloxifene vector against triple-negative breast cancer

Author

Kazimir, Aleksandr, Götze, Tom, Murganić, Blagoje, Mijatović, Sanja, Maksimović-Ivanić, Danijela, Hey-Hawkins, Evamarie, Kazimir, Aleksandr, Götze, Tom, Murganić, Blagoje, Mijatović, Sanja, Maksimović-Ivanić, Danijela, and Hey-Hawkins, Evamarie

Abstract

Raloxifene, a selective oestrogen receptor modulator (SERM), has demonstrated efficacy in the prevention and therapy of oestrogen receptor-positive (ER+) breast cancer, with some degree of effectiveness against triple-negative forms. This suggests the presence of oestrogen receptor-independent pathways in raloxifene-mediated anticancer activity. To enhance the potential of raloxifene against the most aggressive breast cancer cells, hybrid molecules combining the drug with a metal chelator moiety have been developed. In this study, we synthetically modified the structure of raloxifene by incorporating a 2,2′-bipyridine (2,2′-bipy) moiety, resulting in [6-methoxy-2-(4-hydroxyphenyl)benzo[b]thiophen-3-yl]-[4-(2,2′-bipyridin-4′-yl-methoxy)phenyl]methanone (bipyraloxifene). We investigated the cytotoxic activity of both raloxifene and bipyraloxifene against ER+ breast adenocarcinomas, glioblastomas, and a triple-negative breast cancer (TNBC) cell line, elucidating their mode of action against TNBC. Bipyraloxifene maintained a mechanism based on caspase-mediated apoptosis but exhibited significantly higher activity and selectivity compared to the original drug, particularly evident in triple-negative stem-like MDA-MB-231 cells.

Published
2024

5. A general procedure to select calibration drugs for lab-specific validation and calibration of proarrhythmia risk prediction models: An illustrative example using the CiPA model

Author

Han, Xiaomei, Samieegohar, Mohammadreza, Ridder, Bradley J., Wu, Wendy W., Randolph, Aaron, Tran, Phu, Sheng, Jiansong, Stoelzle-Feix, Sonja, Brinkwirth, Nina, Rotordam, Maria Giustina, Becker, Nadine, Friis, Søren, Rapedius, Markus, Goetze, Tom A., Strassmaier, Tim, Okeyo, George, Kramer, James, Kuryshev, Yuri, Wu, Caiyun, Strauss, David G., and Li, Zhihua

Published
2020
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9. Bipyraloxifene – a modified raloxifene vector against triple-negative breast cancerElectronic supplementary information (ESI) available. See DOI: https://doi.org/10.1039/d4md00051j

Author

Kazimir, Aleksandr, Götze, Tom, Murgani, Blagoje, Mijatovi, Sanja, Maksimovi-Ivani, Danijela, and Hey-Hawkins, Evamarie

Abstract

Raloxifene, a selective oestrogen receptor modulator (SERM), has demonstrated efficacy in the prevention and therapy of oestrogen receptor-positive (ER+) breast cancer, with some degree of effectiveness against triple-negative forms. This suggests the presence of oestrogen receptor-independent pathways in raloxifene-mediated anticancer activity. To enhance the potential of raloxifene against the most aggressive breast cancer cells, hybrid molecules combining the drug with a metal chelator moiety have been developed. In this study, we synthetically modified the structure of raloxifene by incorporating a 2,2′-bipyridine (2,2′-bipy) moiety, resulting in [6-methoxy-2-(4-hydroxyphenyl)benzo[b]thiophen-3-yl]-[4-(2,2′-bipyridin-4′-yl-methoxy)phenyl]methanone (bipyraloxifene). We investigated the cytotoxic activity of both raloxifene and bipyraloxifene against ER+ breast adenocarcinomas, glioblastomas, and a triple-negative breast cancer (TNBC) cell line, elucidating their mode of action against TNBC. Bipyraloxifene maintained a mechanism based on caspase-mediated apoptosis but exhibited significantly higher activity and selectivity compared to the original drug, particularly evident in triple-negative stem-like MDA-MB-231 cells.

Published
2024
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10. Intensity dependent deflection spectroscopy for absorption measurements

Author

Dickmann Walter, Götze Tom, Bieler Mark, and Kroker Stefanie

Subjects
Physics, QC1-999
Abstract

We report on a method for the characterization of optical absorption in semiconductors at photon energies below the bandgap energy. We use intensity dependent deflection spectroscopy to measure spatially resolved the optical absorption and to separate the occurring absorption mechanisms. To this end, we take advantage of the different intensity scaling of these mechanisms and extract the material parameters by fitting the intensity dependent absorption to a physical model. Our method enables a simple but sufficient determination of crucial optical loss properties (e.g. impurity related absorption and two-photon absorption) in various semiconductor systems, e.g. substrates for optical components or solar cells.

Published
2020
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11. Intensity dependent deflection spectroscopy for the characterization of absorption mechanisms in semiconductors.

Author

Dickmann, Walter, Götze, Tom, Bieler, Mark, and Kroker, Stefanie

Subjects
*ABSORPTION coefficients, *LIGHT absorption, *ABSORPTION, *SPECTRUM analysis, *SEMICONDUCTORS
Abstract

We report on a simple method for the characterization of optical absorption in semiconductors at photon energies below the bandgap energy. Therefore, we perform spatially resolved and intensity dependent deflection spectroscopy to measure the local optical absorption. To separate the absorption mechanisms, we take advantage of different intensity scaling of these mechanisms and extract the material parameters by fitting intensity dependent absorption to a physical model. This model takes into account relevant optical absorption processes like linear absorption from defect states, two-photon absorption, and the Franz–Keldysh effect. The method is exemplarily carried out for GaAs, Si, and CdTe. The literature values of the two-photon absorption coefficient are reproduced and the strength of the Franz–Keldysh effect in CdTe is determined for the first time as C FK = [ 8.7 , ... , 16.9 ] × 10 13 m − 1 s − 1 / 2 . [ABSTRACT FROM AUTHOR]

Published
2020
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12. How to Bring Young Chemists Together Online

Author

Abel, Ken Luca, primary, Götze, Tom, additional, Herbstritt, Domenique, additional, Herz, Maria Annette, additional, Lebelt, Jonathan, additional, Schelhorn, Isabell, additional, Springer, Maximilian A., additional, Herrmann, Lukas, additional, and Roßberg, Pascal L., additional

Published
2022
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15. Bridging HTS Ion channel and myocyte data

Author

Ohtsuki, Atsushi, Stoelzle-Feix, Sonja, Strassmaier, Tim, Okeyo, George, Bot, Corina, Juhasz, Krisztina, Becker, Nadine, Thomas, Ulrich, Doerr, Leo, Rapedius, Markus, Brinkwirth, Nina, Haarmann, Claudia, Goetze, Tom, Beckler, Matthias, George, Michael, and Fertig, Niels

Published
2019
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17. An “All Inclusive “Package for Cardiac Safety: The Six Big on One Automated Patch Clamp Chip

Author

Bot, Corina, primary, Stölzle-Feix, Sonja, additional, Becker, Nadine, additional, Thomas, Ulrich, additional, Juhasz, Krisztina, additional, Doerr, Leo, additional, Beckler, Matthias, additional, Haarmann, Claudia, additional, Obergrussberger, Alison, additional, Rapedius, Markus, additional, Götze, Tom, additional, Vogel, Marius, additional, George, Michael, additional, Brüggemann, Andrea, additional, Haedo, Rodolfo, additional, and Fertig, Niels, additional

Published
2017
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20. Electrophysiological Characterization of TMEM16A

Author

Bruggemann, Andrea, primary, Rapedius, Markus, additional, Götze, Tom, additional, Haarmann, Claudia, additional, Rinke, Ilka, additional, Vogel, Marius, additional, Stengel, Timo, additional, Stiehler, Johannes, additional, George, Michael, additional, Fertig, Niels, additional, and Ertongur-Fauth, Torsten, additional

Published
2015
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23. Intensity dependent deflection spectroscopy for absorption measurements.

Author

Michinel, H., Costa, M.F., Frazao, O., Dickmann, Walter, Götze, Tom, Bieler, Mark, and Kroker, Stefanie

Subjects
PHOTONIC band gap structures, PLASMONICS, INTERFEROMETERS, NANOPHOTONICS, MICROSPHERES
Abstract

We report on a method for the characterization of optical absorption in semiconductors at photon energies below the bandgap energy. We use intensity dependent deflection spectroscopy to measure spatially resolved the optical absorption and to separate the occurring absorption mechanisms. To this end, we take advantage of the different intensity scaling of these mechanisms and extract the material parameters by fitting the intensity dependent absorption to a physical model. Our method enables a simple but sufficient determination of crucial optical loss properties (e.g. impurity related absorption and two-photon absorption) in various semiconductor systems, e.g. substrates for optical components or solar cells. [ABSTRACT FROM AUTHOR]

Published
2020
Full Text
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