117 results on '"Görker, Işık"'
Search Results
2. Validity and reliability of the Turkish version of Sleep Disturbance Scale for Children
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Ağca, Seray, Görker, Işık, Turan, Fatma Nesrin, and Öztürk, Levent
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- 2021
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3. Investigation of Pogz Gene Variants in Non-Syndromic Autism Spectrum Disorder.
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TOZKIR, Jülide, YILDIRIM, Gökberk, DEMİR, Selma, PALABIYIK, Orkide, GÖRKER, Işık, and GÜRKAN, Hakan
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DIAGNOSIS of autism ,GENETICS of autism ,SOCIAL sciences ,GENOMICS ,CLASSIFICATION of mental disorders ,DNA ,CHI-squared test ,DESCRIPTIVE statistics ,GENETIC variation ,MESSENGER RNA ,NUCLEOTIDES ,GENETIC polymorphisms ,CHROMOSOMES ,ASPERGER'S syndrome ,CASE studies ,DATA analysis software ,SEQUENCE analysis ,COMORBIDITY ,GENOTYPES - Abstract
Introduction: Genetic factors play an important role in the etiopathogenesis of autism spectrum disorder (ASD). The Pogo Transposable Element with ZNF Domain protein (POGZ) gene (MIM*614787) has been reported to be one of the most frequently mutated genes associated with ASD. This study aims to analyze the exonic regions of the POGZ gene in individuals diagnosed with non-syndromic ASD. Methods: Fifty-one non-syndromic cases diagnosed with ASD according to the DSM-V diagnostic criteria, aged 2-18 years, were included in the study. The healthy control group consisted of 50 children of similar age groups without neurodevelopmental problems. Amplicons produced using deep intronic primers covering the mRNA-encoded regions of the POGZ gene from at least 50 base pairs were sequenced by Next Generation Sequencing Analysis. Results: No pathogenic or likely pathogenic variants reported in open-access databases (ClinVar, HGMD, etc.) were detected in the case group. In the ASD and healthy control groups, rs113396244, rs11204811, rs779479223, rs772352054, rs3831142, rs112072925, rs227453 and rs142860188 variants were determined. The rs3831142, rs112072925, rs2274535, rs142860188 variants were found statistically significant in the ASD group. The distribution of the cases with detected single nucleotide polymorphisms (SNPs) according to gender was not statistically significant. Conclusion: The variants identified as statistically significant within the patient group are situated in regions that encompass both the HP1-ZNF and DDE domains of the protein. Given the crucial role that the DDE domain plays, particularly in fetal brain development and neurogenesis, these four variants may potentially possess modifying and/or predisposing effects in the context of ASD. [ABSTRACT FROM AUTHOR]
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- 2024
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4. Children at Risk of Specific Learning Disorder: A Study on Prevalence and Risk Factors.
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Bozatlı, Leyla, Aykutlu, Hasan Cem, Sivrikaya Giray, Açelya, Ataş, Tuğçe, Özkan, Çisem, Güneydaş Yıldırım, Burcu, and Görker, Işık
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RISK assessment ,T-test (Statistics) ,MENTAL illness ,QUESTIONNAIRES ,MOTHERS ,SMOKING ,NEONATAL intensive care units ,DYSLEXIA ,MULTIPLE regression analysis ,DESCRIPTIVE statistics ,NEONATAL intensive care ,SCREEN time ,QUANTITATIVE research ,MANN Whitney U Test ,CHI-squared test ,EARLY intervention (Education) ,SURVEYS ,SCHOOL children ,FATHERS ,RESEARCH methodology ,STATISTICS ,SOCIODEMOGRAPHIC factors ,CONFIDENCE intervals ,COMPARATIVE studies ,DATA analysis software ,LEARNING disabilities ,EDUCATIONAL attainment ,COMORBIDITY ,DISEASE risk factors ,CHILDREN - Abstract
Background: Specific learning disorder (SLD) is a neurodevelopmental condition characterised by significant academic difficulties despite normal intelligence and adequate education. The difficulties with reading, writing, and arithmetic may manifest independently or concurrently at different ages. Early symptoms may appear in preschool, including delays in social skills, motor skills, and language development. This study aimed to assess the prevalence of preschool children at risk for SLD and related psychiatric disorders. Method: Data were collected from 515 preschool children in Edirne City, Turkey, using a screening scale for early symptoms of SLD. Socio-demographic information was obtained, and children at risk were invited for a psychiatric evaluation. Results: The mean age of the participants was 72.5 ± 5.6 months. It was determined that 5.7% of the preschool children who participated in the questionnaire were at risk of SLD according to the screening scale scores. Factors such as a father's low education, the mother smoking during pregnancy, a longer stay in the neonatal intensive care unit, longer screen time, and consanguinity between parents were associated with an increased risk of SLD. Conclusion: This study emphasises the importance of early identification and intervention for SLD and the need to consider associated psychiatric comorbidities. Identifying the risk factors in preschool children may facilitate timely intervention and prevent academic and social difficulties in later years. [ABSTRACT FROM AUTHOR]
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- 2024
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5. Drug-refractory irritability and related factors in autistic children
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Aykutlu, Hasan C., primary, Bozatlı, Leyla, additional, Görker, Işık, additional, Okyar, Esra, additional, Uzun-Çiçek, Ayla, additional, Ucuz, İlknur, additional, Doğru, Hicran, additional, Baykal, Saliha, additional, Bilaç, Öznur, additional, Arslan, Esra N., additional, Yıldız, Nazike, additional, Alnak, Alper, additional, Turnalı, Nursena, additional, and Sobay, Nurten S., additional
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- 2024
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6. How Did the Pandemic Affect Autistic Children and Their Families? Challenges and Psychosocial Impacts
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AYKUTLU, Hasan Cem, primary, GÜNEYDAŞ YILDIRIM, Burcu, additional, BOZATLI, Leyla, additional, KÖSE, Ekin Beyza, additional, and GÖRKER, Işık, additional
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- 2023
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7. The Prevalence and Gender Differences in Specific Learning Disorder
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Görker, Işık, primary
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- 2020
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8. Anxiety and Somatic Symptoms in Children and Adolescents Diagnosed with Attention-Deficit Hyperactivity Disorder
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Okyar, Esra, primary, Bozatlı, Leyla, additional, Görker, Işık, additional, and Okyar, Serap, additional
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- 2023
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9. Examining the autistic traits in children and adolescents diagnosed with attention-deficit hyperactivity disorder and their parents
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Okyar, Esra and Görker, Işık
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- 2020
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10. Investigation the Relationship of Autism Spectrum Disorder and FOXP2, GRIN2B, KATNAL2, GABRA4 Genes
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YALÇINTEPE, Sinem, GÖRKER, Işık, DEMİR, Selma, ATLI, Emine İkbal, ATLI, Engin, TOZKIR, Hilmi, SÜT, Necdet, ÖZEN, Yasemin, EKER, Damla, MAİL, Çisem, GÜLER, Hazal SEZGİNER, ZHURI, Drenushe, and GURKAN, Hakan
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GABRA4 ,Next generation sequencing ,FOXP2 ,KATNAL2 ,Autism spectrum disorder ,GRIN2B ,Research Article - Abstract
Introduction: Autism spectrum disorder is a genetically and phenotypically heterogeneous group. Genetic studies carried out to date have suggested that both common and rare genetic variants play a role in the etiology of this disorder. In our study, we aimed to investigate the effect of FOXP2, GRIN2B, KATNAL2 and GABRA4 gene variants in the pathogenesis of autism spectrum disorder. Method: In our prospectively planned study, all exons and exon-intron junctions of FOXP2, GRIN2B, KATNAL2 and GABRA4 genes were screened by next generation sequencing analysis in 96 patients who diagnosed with autism spectrum disorder. Results: In our study, the average age was 10.1 and the male/female ratio was 75/21. Pathogenic or likely pathogenic variants were not detected in FOXP2, GRIN2B, KATNAL2 and GABRA4 genes, however, 69 intronic variants of unknown clinical significance were detected in 50 cases (52%). Among those, 26 were in the GABRA4 gene, 22 in the FOXP2 gene, 13 in the KATNAL2 gene, and 8 in the GRIN2B gene. Twenty three of these 69 variants were novel that were not previously reported in the literature. Conclusion: In our study, we could not identify a relationship between the autism spectrum disorder and FOXP2, GRIN2B, KATNAL2 and GABRA4 genes. Identifying genetic risk factors that play a role in the etiopathogenesis of autism spectrum disorder will contribute significantly to understanding the molecular mechanisms of the disease and the development of new treatment strategies. In this context, comprehensive molecular genetic studies such as whole exome or whole genome sequencing are required with higher number of cases in different populations.
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- 2021
11. DİKKAT EKSİKLİĞİ VE HİPERAKTİVİTE BOZUKLUĞU TANISI ALAN ÇOCUK VE ERGENLERDE UZUN SÜRELİ METİLFENİDAT KULLANIMININ BÜYÜME VE KEMİK YOĞUNLUĞU ÜZERİNE ETKİLERİNİN ARAŞTIRILMASI
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ŞAHİN, Zeynep Anıl, primary, ŞAHİN, İsmail Gökhan, additional, BOZATLI, Leyla, additional, and GÖRKER, Işık, additional
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- 2022
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12. A nationwide study of social–emotional problems in young children in Turkey
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Karabekiroglu, Koray, Uslu, Runa, Kapci-Seyitoglu, Emine G., Özbaran, Burcu, Öztop, Didem B., Özel-Özcan, Özlem, Dogangün, Burak, Gülen-Sismanlar, Sahika, Görker, Isik, Fidan, Tülin, Bahali, Kayhan M., Barut, Yasar, Gürkan, Kagan, Kilic, Birim G., Ay, Pinar, Taskin, Beril, Bilgin, Nusin, and Cengel-Kültür, Ebru S.
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- 2013
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13. Evaluation of Application Complaints, Co-Diagnoses and Treatments of Children and Adolescents Diagnosed with Enuresis
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Bozatlı, Leyla, primary, Uğurtay, Cansu, additional, Güneydaş, Burcu, additional, and Görker, Işık, additional
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- 2022
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14. Çocukluk ve Ergenlikte Ortopedik Yaralanmalar ve Dikkat Eksikliği Hiperaktivite Bozukluğu Arasındaki İlişkinin Değerlendirilmesi
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Şahin, Zeynep Anıl, Şahin, İsmail Gökhan, Görker, Işık, and Bozatlı, Leyla
- Abstract
Amaç: Dikkat eksikliği hiperaktivite bozukluğu (DEHB), çocukluk çağında tekrarlayan travma ve ekstremite yaralanmalarına en fazla neden olannörogelişimsel bozukluktur. Karşıt olma karşı gelme bozukluğu (KOKGB) ve davranım bozukluğu (DB) ise DEHB’ye en sık eşlik eden durumlar olarakbilinmektedir. Çalışmamızda pediatrik travma hastalarında, ekstremite travmaları ve DEHB alt grupları arasındaki korelasyon, kontrol grubu ile karşılaştırılarak araştırılmıştır. Amacımız pediatrik ekstremite travmaları açısından yüksek riskli olguların saptanması ve erken tanı ile olası ekstremite yaralanmalarının önlenmesidir.Gereç ve Yöntem: Eylül 2018-Şubat 2019 tarihleri arasında ekstremite yaralanması bulunan (grup 1) ve travmatik olmayan nedenlerle başvuran (grup 2) toplam 60 çocuk ardışık olarak çalışmaya dahil edildi. Katılımcılar Conners Ebeveyn Değerlendirme Ölçeği ve Güçler Güçlükler Anketi kullanılarak ön değerlendirmeye tabi tutuldu. Riskli olarak saptanan olgular Trakya Üniversitesi Tıp Fakültesi Hastanesi, Çocuk ve Ergen Ruh Sağlığı ve Hastalıkları Kliniği’ne detaylı değerlendirme için yönlendirildi.Bulgular: DEHB tanısı alan olguların sayısı travma grubunda anlamlı olarak daha yüksek saptandı (p=0,042), ancak DEHB alt grupları arasında ve KOKGB ve DB’yi karşılayan olgular arasında, pediatrik travma açısından anlamlı fark saptanmadı. Sonuç: Bulgularımız, güncel literatürün büyük çoğunluğu ile uyumlu olup DEHB, travma grubunda anlamlı olarak daha yüksek saptanmıştır. Pediatrik travma hastalarında olası ekstremite yaralanmalarını önlemek için DEHB’ye dair semptomatoloji dikkate alınmalıdır.
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- 2021
15. Effect of Impairment on the Prevalence and Comorbidities of Attention Deficit Hyperactivity Disorder in a National Survey: Nation-Wide Prevalence and Comorbidities of ADHD
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Ercan, Eyup Sabri, primary, Unsel-Bolat, Gul, additional, Tufan, Ali Evren, additional, Karakoc Demirkaya, Sevcan, additional, Bilac, Oznur, additional, Celik, Goncagul, additional, Kılıç, Birim Günay, additional, Akyol Ardic, Ulku, additional, Yalin Sapmaz, Sermin, additional, Aksu, Hatice, additional, Yolga Tahiroglu, Aysegul, additional, Karacetin, Gul, additional, Tural, Umit, additional, Aktepe, Evrim, additional, Rodopman Arman, Ayşe, additional, Başgül, Senem, additional, Coşkun, Murat, additional, Dursun, Onur Burak, additional, Durukan, İbrahim, additional, Perdahli Fiş, Neşe, additional, Gençoğlan, Salih, additional, Gökçen, Cem, additional, Sarı Gokten, Emel, additional, Görker, Işık, additional, Görmez, Vahdet, additional, Yıldız Gündoğdu, Özlem, additional, Hesapçioğlu, Selma Tural, additional, Kandemir, Hasan, additional, Mutluer, Tuba, additional, Nasiroğlu, Serhat, additional, Özcan, Özlem, additional, Şahin, Nilfer, additional, Toros, Fevziye, additional, Perçinel Yazici, İpek, additional, Yazici, Kemal Utku, additional, Yulaf, Yasemin, additional, Yüksel, Tuğba, additional, Bilgic, Ayhan, additional, Altun, Hatice, additional, Akdemir, Devrim, additional, Mazlum, Betül, additional, Çakın Memik, Nursu, additional, Foto Özdemir, Dilşad, additional, Üneri, Özden, additional, and Ünal, Fatih, additional
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- 2021
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16. Evaluation of the Relationship Between Orthopedic Injuries and Attention Deficit Hyperactivity Disorder in Childhood and Adolescence
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ŞAHİN, İsmail Gökhan, primary, BOZATLI, Leyla, additional, ŞAHİN, Zeynep Anıl, additional, and GÖRKER, Işık, additional
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- 2021
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17. Sleep Disturbance Scale for Children--Turkish Version
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Ağca, Seray, primary, Görker, Işık, additional, Turan, Fatma Nesrin, additional, and Öztürk, Levent, additional
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- 2021
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18. Attention Deficit Hyperactivity Disorder and Psychiatric Comorbidities
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Araz Altay, Mengühan, primary, Görker, Işık, additional, Demirci Şipka, Begüm, additional, Bozatlı, Leyla, additional, and Ataş, Tuğçe, additional
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- 2020
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19. Evaluation of psychiatric characteristics in children of parents with multiple sclerosis
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Altay, Mengühan, primary, Görker, Işık, additional, Güler, Sibel, additional, Şipka, Begüm, additional, and Ataş, Tuğçe, additional
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- 2020
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20. Enürezis Tanısı Alan Çocuk ve Ergenlerin Başvuru Yakınmaları, Eşlik Eden Tanıları ve Tedavilerinin Değerlendirilmesi.
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Bozatlı, Leyla, Uğurtay, Cansu, Güneydaş, Burcu, and Görker, Işık
- Abstract
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- 2022
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21. Current Pattern of Psychiatric Comorbidity and Psychotropic Drug Prescription in Child and Adolescent Patients
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Araz Altay, Mengühan, primary, Bozatlı, Leyla, additional, Demirci Şipka, Begüm, additional, and Görker, Işık, additional
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- 2019
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22. The prevalence of childhood psychopathology in Turkey: a cross-sectional multicenter nationwide study (EPICPAT-T)
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Ercan, Eyup Sabri, primary, Polanczyk, Guilherme, additional, Akyol Ardıc, Ulku, additional, Yuce, Deniz, additional, Karacetın, Gul, additional, Tufan, Ali Evren, additional, Tural, Umit, additional, Aksu, Hatice, additional, Aktepe, Evrim, additional, Rodopman Arman, Ayşe, additional, Başgül, Senem, additional, Bılac, Oznur, additional, Coşkun, Murat, additional, Celık, Gonca Gul, additional, Karakoc Demırkaya, Sevcan, additional, Dursun, Burak Onur, additional, Durukan, İbrahim, additional, Fidan, Tülin, additional, Perdahlı Fiş, Neşe, additional, Gençoğlan, Salih, additional, Gökçen, Cem, additional, Görker, Işık, additional, Görmez, Vahdet, additional, Gündoğdu, Özlem Yıldız, additional, Gürkan, Cihat Kaan, additional, Hergüner, Sabri, additional, Tural Hesapçıoğlu, Selma, additional, Kandemir, Hasan, additional, Kılıç, Birim Günay, additional, Kılınçaslan, Ayse, additional, Mutluer, Tuba, additional, Nasiroğlu, Serhat, additional, Özel Özcan, Özlem, additional, Öztürk, Mücahit, additional, Öztop, Didem, additional, Yalın Sapmaz, Sermin, additional, Süren, Serkan, additional, Şahin, Nilfer, additional, Yolga Tahıroglu, Aysegul, additional, Toros, Fevziye, additional, Ünal, Fatih, additional, Vural, Pınar, additional, Perçinel Yazıcı, İpek, additional, Yazıcı, Kemal Utku, additional, Yıldırım, Veli, additional, Yulaf, Yasemin, additional, Yüce, Murat, additional, Yüksel, Tuğba, additional, Akdemir, Devrim, additional, Altun, Hatice, additional, Ayık, Başak, additional, Bilgic, Ayhan, additional, Hekim Bozkurt, Özlem, additional, Demirbaş Çakır, Emine, additional, Çeri, Veysi, additional, Üçok Demir, Nagehan, additional, Dinç, Gülser, additional, Irmak, Mustafa Yasin, additional, Karaman, Dursun, additional, Kınık, Mehmet Fatih, additional, Mazlum, Betül, additional, Memik, Nursu Çakın, additional, Foto Özdemir, Dilşad, additional, Sınır, Hayati, additional, Ince Taşdelen, Bedia, additional, Taşkın, Beril, additional, Uğur, Çağatay, additional, Uran, Pınar, additional, Uysal, Taciser, additional, Üneri, Özden, additional, Yilmaz, Savas, additional, Seval Yılmaz, Sultan, additional, Açıkel, Burak, additional, Aktaş, Hüseyin, additional, Alaca, Rümeysa, additional, Alıç, Betül Gül, additional, Almaidan, Mahmut, additional, Arı, Fatma Pınar, additional, Aslan, Cihan, additional, Atabay, Ender, additional, Ay, Merve Günay, additional, Aydemir, Hilal, additional, Ayrancı, Gülseda, additional, Babadagı, Zehra, additional, Bayar, Hasan, additional, Çon Bayhan, Pelin, additional, Bayram, Özlem, additional, Dikmeer Bektaş, Neşe, additional, Berberoğlu, Kıvanç Kudret, additional, Bostan, Recep, additional, Arıcı Canlı, Merve, additional, Cansız, Mehmet Akif, additional, Ceylan, Cansın, additional, Coşkun, Neşe, additional, Coşkun, Seyma, additional, Çakan, Yasemin, additional, Demir, İbrahim, additional, Demir, Nuran, additional, Yıldırım Demirdöğen, Esen, additional, Doğan, Büşra, additional, Dönmez, Yunus Emre, additional, Dönder, Funda, additional, Efe, Ayşegül, additional, Eray, Şafak, additional, Erbilgin, Seda, additional, Erden, Semih, additional, Ersoy, Elif Gökçe, additional, Eseroğlu, Tuğba, additional, Kına Fırat, Sümeyra, additional, Eynallı Gök, Ezgi, additional, Güler, Gülen, additional, Güles, Zafer, additional, Güneş, Serkan, additional, Güneş, Adem, additional, Günay, Gülay, additional, Gürbüz Özgür, Börte, additional, Güven, Gökçen, additional, Çelik Göksoy, Şeyda, additional, Horozcu, Havvana, additional, Irmak, Ayşe, additional, Işık, Ümit, additional, Kahraman, Özlem, additional, Kalaycı, Bilge Merve, additional, Karaaslan, Umut, additional, Karadağ, Mehmet, additional, Kılıc, Hilal Tuğba, additional, Kılıçaslan, Fethiye, additional, Kınay, Duygu, additional, Kocael, Ömer, additional, Bulanık Koç, Esra, additional, Kadir Mutlu, Rahime, additional, Lushi-Şan, Zejnep, additional, Nalbant, Kevser, additional, Okumus, Nilüfer, additional, Özbek, Fatih, additional, Akkuş Özdemir, Fatma, additional, Özdemir, Hanife, additional, Özkan, Selçuk, additional, Yıldırım Özyurt, Esra, additional, Polat, Berna, additional, Polat, Hatice, additional, Sekmen, Ebru, additional, Sertçelik, Mehmet, additional, Sevgen, Feyza Hatice, additional, Sevince, Oğuz, additional, Süleyman, Funda, additional, Shamkhalova, Ülker, additional, Eren Şimşek, Nurcan, additional, Tanır, Yaşar, additional, Tekden, Mehmet, additional, Temtek, Seyhan, additional, Topal, Melike, additional, Topal, Zehra, additional, Türk, Tuğba, additional, Uçar, Halit Necmi, additional, Uçar, Filiz, additional, Uygun, Duygu, additional, Uzun, Necati, additional, Vatansever, Zeynep, additional, Yazgılı, Neslihan Gökçe, additional, Miniksar Yıldız, Dilşat, additional, and Yıldız, Nazike, additional
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- 2019
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23. Atomoxetine Treatment In A Patient With The Comorbidity Of Attention Deficit Hyperactivity Disorder And Fragile X Syndrome.
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Okyar, Esra, primary, Bozatlı, Leyla, additional, and Görker, Işık, additional
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- 2019
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24. Assessment of psychiatric disorders accompanying Hashimoto's thyroiditis in children and adolescents
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Berberoğlu, Kıvanç, primary and Görker, Işık, additional
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- 2019
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25. Disruptive eating behavior and obesity in drug naïve children diagnosed with attention deficit hyperactivity disorder
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Aykutlu, Hasan, primary and Görker, Işık, additional
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- 2019
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26. Evaluation of psychiatric characteristics in children of parents with multiple sclerosis.
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ARAZ ALTAY, Mengühan, GÖRKER, Işık, GÜLER, Sibel, DEMİRCİ ŞİPKA, Begüm, and ATAŞ, Tuğçe
- Subjects
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DISEASES in youths , *MULTIPLE sclerosis , *TIC disorders , *MENTAL illness , *ATTENTION-deficit hyperactivity disorder , *PARENTS , *AFFECTIVE disorders - Abstract
Objective: This study aims to investigate the psychiatric disorders in children with parental multiple sclerosis (MS) and to research the differences between without parental chronic disease. Methods: The children of the parents with MS diagnosis in the neurology department and the children of parents without chronic medical and psychiatric diseases were included in the study. Kiddie Schedule for Affective Disorders and Schizophrenia for School Aged Children Present and Lifetime Version (K-SADS-PL) was applied to the children. Structured Clinical Interview for DSM-IV Axis I Disorders, Clinical Version (SCID-I-CV) was applied to parents with MS. Psychiatric characteristics of the parents and children were determined. The accompanying psychiatric disorders in children and adolescents with paternal MS and the clinical features affecting these disorders were analyzed. Results: Fifty children and adolescents with parental MS were included in the study group and 75 children and adolescents without a chronic disease in the parents were included in the control group. The mean age of children in the study group was 12.7±2.9 years and 58% were girls. 52% of the parents with MS were diagnosed with a psychiatric disorder. As a result of the evaluation, 54% of the children with parental MS were diagnosed with psychiatric disorder. The most common psychiatric diagnoses were anxiety disorders (30%), attention deficit and hyperactivity disorder (ADHD) (22%), and tic disorders (16%), respectively. The Expanded Disability Status Scale scores of the parents of children with psychiatric diagnoses were significantly higher than those of the children with no diagnosis. Conclusion: Children of MS patients have a high rate of psychiatric disorder. As the severity of MS increases, it is more common for children to be affected psychosocially. Children with parental MS should be follow-up for psychiatric disorders, especially for anxiety disorders and ADHD. [ABSTRACT FROM AUTHOR]
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- 2020
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27. Chromosomal Microarray Analysis in Turkish Patients with Unexplained Developmental Delay and Intellectual Developmental Disorders.
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GÜRKAN, Hakan, ATLI, Emine İkbal, ATLI, Engin, BOZATLI, Leyla, ALTAY, Mengühan ARAZ, YALÇINTEPE, Sinem, ÖZEN, Yasemin, EKER, Damla, AKURUT, Çisem, DEMİR, Selma, and GÖRKER, Işık
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CHROMOSOME analysis ,CHROMOSOME abnormalities ,DEVELOPMENTAL disabilities ,PEOPLE with intellectual disabilities ,GENOMICS ,MICROARRAY technology - Abstract
Introduction: Aneuploids, copy number variations (CNVs), and single nucleotide variants in specific genes are the main genetic causes of developmental delay (DD) and intellectual disability disorder (IDD). These genetic changes can be detected using chromosome analysis, chromosomal microarray (CMA), and next-generation DNA sequencing techniques. Therefore; In this study, we aimed to investigate the importance of CMA in determining the genomic etiology of unexplained DD and IDD in 123 patients. Method: For 123 patients, chromosome analysis, DNA fragment analysis and microarray were performed. Conventional G-band karyotype analysis from peripheral blood was performed as part of the initial screening tests. FMR1 gene CGG repeat number and methylation analysis were carried out to exclude fragile X syndrome. Results: CMA analysis was performed in 123 unexplained IDD/DD patients with normal karyotypes and fragile X screening, which were evaluated by conventional cytogenetics. Forty-four CNVs were detected in 39 (39/123=31.7%) patients. Twelve CNV variant of unknown significance (VUS) (9.75%) patients and 7 CNV benign (5.69%) patients were reported. In 6 patients, one or more pathogenic CNVs were determined. Therefore, the diagnostic efficiency of CMA was found to be 31.7% (39/123). Conclusion: Today, genetic analysis is still not part of the routine in the evaluation of IDD patients who present to psychiatry clinics. A genetic diagnosis from CMA can eliminate genetic question marks and thus alter the clinical management of patients. Approximately one-third of the positive CMA findings are clinically intervenable. However, the emergence of CNVs as important risk factors for multiple disorders increases the need for individuals with comorbid neurodevelopmental conditions to be the priority where the CMA test is recommended. [ABSTRACT FROM AUTHOR]
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- 2020
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28. Case Reports Presentations
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Dinçer, Mustafa, primary, Çelik, Cemil, additional, Helvalı, Elif Ecem, additional, Bodur, Şahin, additional, Akçaer, Emine Tuğçe, additional, Can, Serdar Süleyman, additional, Uğurlu, Görkem Karakaş, additional, İslamoğlu, Sümeyye, additional, Kaymak, Semra Ulusoy, additional, Taştorun, Yasemin, additional, Peker, Oğuz, additional, Çayköylü, Ali, additional, Soğucak, Zehra Ece, additional, Adanır, Aslı Sürer, additional, Özatalay, Esin, additional, Önder, Arif, additional, Başaran, Abdurrahman Erdem, additional, Bingöl, Ayşen, additional, Akdağ, Berhan, additional, Atagün, Murat İlhan, additional, Doğan, Yakup, additional, Bilaç, Öznur, additional, Kavurma, Canem, additional, Taşkıran, Gülseren, additional, Erdem, Aybike, additional, Kocagöz, Zehra Başar, additional, Özçetin, Adnan, additional, Ataoğlu, Ahmet, additional, Toraman, Merve Çavdar, additional, Özçelik, Özgen, additional, Kara, Hüseyin, additional, Tomar, Talya, additional, Cinemre, Buket, additional, Tokgöz, Yusuf, additional, Öznur, Taner, additional, Bolu, Abdullah, additional, Uzun, Özcan, additional, İnanlı, İkbal, additional, Altunova, Deniz, additional, Çalışkan, Ali Metehan, additional, Eren, İbrahim, additional, Elmas, Tüba Şerife, additional, Gökçenoğlu, Yasemin, additional, Çalışır, Saliha, additional, Tanrıkulu, Ali Baran, additional, Bozdoğan, Şenay Yıldız, additional, Şahin, Fatma, additional, Çamur, Ceren, additional, Gündoğmuş, İbrahim, additional, Karagöz, Abdulkadir, additional, Algül, Ayhan, additional, Doneray, Ebru, additional, Yazici, Ipek Percinel, additional, Yazici, Kemal Utku, additional, Adanır, Aslı, additional, Işıldar, Yetiş, additional, Sağlam, Ebru, additional, Bilgiç, Ayhan, additional, Akbaş, Betül, additional, Çelikkol, Çağla, additional, Öztürrk, Seher Serez, additional, Seven, Hilal, additional, Demiröz, Dudu, additional, Özbek, Seda, additional, Çiçek, İsmet Esra, additional, Coşkun, Fatma, additional, Akça, Ömer Faruk, additional, Sevinçok, Doğa, additional, Memiş, Çağdaş Öykü, additional, Çakaloz, Burcu, additional, İlhan, Bilge Çetin, additional, Elmas, Tuba Şerife, additional, Yaşar, Azra Sehure, additional, Yağlı, Nafiye, additional, Ak, Osman, additional, Başaran, Recep, additional, Balcı, Mehmet Murat, additional, Kuloğlu, Mehmet Murat, additional, Taş, İbrahim, additional, Yaşar, Sehure Azra, additional, Yıldız, Mustafa Çağrı, additional, Çiftçi, Ebru, additional, Guler, Hasan Ali, additional, Kandeger, Ali, additional, Guler, Dilara, additional, Turkoglu, Serhat, additional, Küçük, Önder, additional, Yaylacı, Ferhat, additional, Erkuran, Handan Özek, additional, Gürsoy, Betül Kurtses, additional, Öztürk, Seher Serez, additional, Ünal, Berrin, additional, Aral, Gizem, additional, Karagüzel, Evrim Özkorumak, additional, Aykut, Demet Sağlam, additional, Arslan, Filiz Civil, additional, Karagöz, Ezgi, additional, İnaloğlu, Neslihan Emir, additional, Uzun, Necati, additional, Özbek, Mutlu Muhammed, additional, Tunagür, Mustafa Tolga, additional, Doğan, Bilge, additional, Sevinçok, Levent, additional, Akgün, Abdullah, additional, Özmenler, Kamil Nahit, additional, Kara, Tayfun, additional, Akaltun, İsmail, additional, Kaya, Ayşe Erdoğan, additional, Yazıcı, Esra, additional, Sezer, Muhammed Nurullah, additional, Turan, Çağlar, additional, Sert, Engin, additional, Yıldırım, Yusuf Ezel, additional, Aydın, Pınar Çetinay, additional, Kunt, Sevilay, additional, Berkol, Tonguç Demir, additional, Esnafoglu, Erman, additional, Adıgüzel, Öznur, additional, Tunc, Serhat, additional, Basbug, Hamit Serdar, additional, Dalyan, Selçuk, additional, Ulgar, Şermin Bilgen, additional, Ayaydın, Hamza, additional, Bozbey, Sema, additional, Yazıcı, Merve, additional, Yektaş, Çiğdem, additional, Sarıgedik, Enes, additional, Asoğlu, Mehmet, additional, Ekmen, Betül Uyar, additional, Akçalı, Hasan, additional, Taş, Cuma, additional, Işık, Cansu Mercan, additional, Demirci, Belde, additional, Sarı, Seda Aybüke, additional, Çiçek, Ayla Uzun, additional, Eynalli, Ezgi, additional, Metin, Ozge, additional, Ray, Perihan Cam, additional, Tahiroglu, Aysegul Yolga, additional, Celik, Gonca Gul, additional, Akçaer, Tuğçe, additional, Kurt, Elif Merve, additional, Göncüoğlu, İbrahim Özkan, additional, Ak, İsmail, additional, Chasan, Merve Tsakir, additional, Tamam, Lut, additional, Çakmak, Soner, additional, Demirkol, Mehmet Emin, additional, Örnek, Erdem, additional, Kani, Ayşe Sakallı, additional, Topçuoğlu, Volkan, additional, Sivri, Rukiye Çolak, additional, Çetin, Nihal Yurteri, additional, Sertdemir, Merve, additional, Ürer, Emre, additional, Ekici, Gökçen İlçioğlu, additional, Kılıç, Birim Günay, additional, Turgut, Keziban, additional, Karci, Canan Kuygun, additional, Avci, Ayse, additional, Yaşar, Azra, additional, Kaplan, Sümeyra Elif, additional, Muhsinoglu, Hazal, additional, Zıblak, Alper, additional, Kenar, Ayşe Nur İnci, additional, Can, Cantekin, additional, Karcı, Canan Kuygun, additional, Kutlu, Gamze, additional, Soykan, Çağlar, additional, Şen, Cansu Pınar, additional, Ceylan, Mehmet Fatih, additional, Hesapçıoğlu, Selma Tural, additional, Öneri, Özden Şükran, additional, Karataş, Abdullah, additional, Altun, Hatice, additional, Karaaslan, Umut, additional, Kasar, Nurdan, additional, Şahin, Nilfer, additional, Balkan, Damla, additional, İbiloğlu, Aslıhan Okan, additional, Atli, Abdullah, additional, Erdogan, Rabia, additional, Yazici, Esra, additional, Mutu, Tugba, additional, Ciner, Ozlem Akcay, additional, Cilli, Ali Savas, additional, Erol, Atila, additional, Zayman, Esra Porgalı, additional, Darılmaz, Cengiz, additional, Reyhani, İsmail, additional, Karlıdağ, Rıfat, additional, Yıldırım, Kübra, additional, Dönmez, Yunus Emre, additional, Karatoprak, Serdar, additional, Özcan, Özlem, additional, Öztürk, Ali Hakan, additional, Üneri, Özden Şükran, additional, Gürbüz, Perihan Turhan, additional, Uğurlu, Mustafa, additional, Doğan, Özlem, additional, Yoldaş, Tahir Kurtuluş, additional, Bilgen, Nuran, additional, Altınyazar, Vesile, additional, Özbek, Muhammed Mutlu, additional, Ulu, Ebru, additional, Demirci, Esra, additional, Özmen, Sevgi, additional, Yeşilkaya, Ümit Haluk, additional, Onur, Ozge Sahmelikoglu, additional, Akay, Omer, additional, Balcioglu, Yasin Hasan, additional, Oncu, Fatih, additional, Yalvaç, Çiğdem Toklu, additional, Işık, Ümit, additional, Erkan, Erol, additional, Örüm, Mehmet Hamdi, additional, Bildik, Tezan, additional, Kara, Mahmut Zabit, additional, Yılmaz, Helin, additional, Tahıllıoğlu, Hasan Akın, additional, Kalenderoğlu, Aysun, additional, Eğilmez, Oğuzhan Bekir, additional, Özen, Murat Eren, additional, Kapıcı, Yaşar, additional, Kılıçoğlu, Ümit, additional, Atmaca, Murad, additional, Karimova, Gulgaz, additional, Arıcı, Asiye, additional, Sevgen, Feyza Hatice, additional, Alğan, Zehra, additional, Dalboy, Fadime, additional, Ak, Mehmet, additional, Uğuz, Faruk, additional, Kılınç, Kübra, additional, Çetin, Fatih Hilmi, additional, Türkoğlu, Serhat, additional, Yılmaz, Semra, additional, İbiloğlu, İbrahim, additional, Özkan, Mustafa, additional, Bertizlioğlu, Osman, additional, Yazar, Ece Merve, additional, Özercan, Ahmet, additional, Kuşçu, Mehmet Kemal, additional, Akbolat, Muhammet, additional, Ekinci, Gazanfer, additional, Midi, İpek, additional, Harmankaya, Fatih Mücahit, additional, Aydın, Adem, additional, Yazar, Neslihan, additional, Ataoğlu, Busra Bahar, additional, Küpeli, Neşe Yorguner, additional, Bulut, Necati Serkut, additional, Kora, Kaan, additional, Yükselir, Cihad, additional, Zincir, Serkan, additional, Miniksar, Dilşad Yıldız, additional, Bayhan, Pelin Çon, additional, Pirinççioğlu, Faruk, additional, Karka, İsmail, additional, Göbelek, Meltem, additional, Akıl, Öznur, additional, Güngören, Sümeyra, additional, Özturan, Deniz Deniz, additional, Yılmaz, Zeynep Bebek, additional, Kürekçi, Derya Deniz, additional, Özturan, Aykut, additional, Ünay, Mihriban, additional, Aytaç, Hasan Mervan, additional, Aydın, Nazan, additional, Tuncer, Can, additional, Seneger, Volkan, additional, Kahraman, Burcu Bakar, additional, Avcı, Selma Hilal, additional, Karatepe, Hasan Turan, additional, Arslan, Mehmet, additional, Çalışkan, Sıla, additional, Çokünlü, Yusuf, additional, Yücehan, Zeynep, additional, Öztrük, Seher Serez, additional, Özayhan, Hatice Yardım, additional, Karakaya, Özlem, additional, Turan, Gökçen, additional, Elbeyli Ahmet, Burak, additional, Ölmez, Safiye Bahar, additional, Çavdar, Merve, additional, Aktepe, Evrim, additional, Avşar, Pınar Aydoğan, additional, Erdoğan, Yakup, additional, Beğinoğlu, Özlem, additional, Elbay, Rümeysa Yeni, additional, Gülşen, Hayriye Hızarcıoğlu, additional, Yılmaz, Arzu, additional, İmrek, Yasemin, additional, Sari, Mesut, additional, Pala, Büşra, additional, Öztürk, Yusuf, additional, Göl, Güler, additional, Cansız, Mehmet Akif, additional, Savcı, Uğur, additional, Çıtır, Berna Gündüz, additional, Aksu, Hatice, additional, Salihoğlu, Sema Çam, additional, Birer, Nurhak Çağatay, additional, Özkula, Güler, additional, Altınörs, Ercan, additional, Baz, Fatih, additional, Yıldız, Mesut, additional, Bozatlı, Leyla, additional, Aykutlu, Hasan Cem, additional, Görker, Işık, additional, Sapdüzen, Oğuzhan, additional, Hocaoğlu, Çiçek, additional, Anak, Alphan, additional, Yılmaz, Mesut, additional, Doymaz, Yeliz, additional, Ayyıldız, Ece, additional, Baltacıoğlu, Mehmet, additional, Kayıpmaz, Selvi Ceran, additional, Altınöz, Ali Ercan, additional, Oğuz, Arzu, additional, Salihoglu, Sema Çam, additional, Gerçek, Hacer Gizem, additional, Cöngöloğlu, Mehmet Ayhan, additional, Subas, Emre, additional, Alkan, Selin, additional, Yalcin, Suat, additional, Donmezler, Suleyman, additional, Kilinc, Sevilay Umut, additional, Yalcin, Burcu Hamurisci, additional, Ozgen, Guliz, additional, Turkcan, Ahmet, additional, Kaypak, Ayse Ceren, additional, Kupeli, Nese Yorguner, additional, İnaltekin, Ali, additional, Yağcı, İbrahim, additional, Kıvrak, Yüksel, additional, Çim, Emine Füsun Akyüz, additional, Delikanli, Leyla, additional, Tuncturk, Mustafa, additional, Karakus, Oguz Bilal, additional, Kılıcoglu, Ali Guven, additional, Karacetin, Gul, additional, Okuyan, Merve, additional, İvelik, Halil İbrahim, additional, Okumuş, Burak, additional, Tekdemir, Rukiye, additional, Aydın, Memduha, additional, Taştekin, Nihal, additional, Kırşavoğlu, Betül, additional, Yalçın, Murat, additional, Ayvaz, Sibel, additional, Kırımlı, Ayşe Gülşah, additional, Kul, Ayşegül Taşdelen, additional, Pasli, Huda, additional, Ozkan, Mine, additional, and Volkan, Ferda, additional
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- 2018
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29. Symposium Oral Presentations
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Çeri, Veysi, primary, Aykutlu, Hasan Cem, additional, Görker, Işık, additional, Akça, Ömer Faruk, additional, Tarakçıoğlu, Mahmut Cem, additional, Aksoy, Umut Mert, additional, Kaya, Heysem, additional, Sertdemir, Merve, additional, İnce, Ezgi, additional, Kadak, Muhammed Tayyib, additional, Yalçın, Gökşen Yüksel, additional, Guliyev, Cavid, additional, Bilgiç, Ayhan, additional, Çiftçi, Elvan, additional, Tekin, Kinyas, additional, Tuna, Zehra Olcay, additional, Oğuzdoğan, Burcu, additional, Duman, Nagihan Saday, additional, Semerci, Bengi, additional, Üneri, Özden Şükran, additional, Karabekiroglu, Koray, additional, Mutluer, Tuba, additional, Nebioglu, Melike, additional, Başgül, Şaziye Senem, additional, Naharcı, Mehmet İlkin, additional, Maden, Özgür, additional, Hocaoğlu, Çiçek, additional, Durmaz, Onur, additional, Usta, Haluk, additional, Boşgelmez, Şükriye, additional, Puşuroğlu, Meltem, additional, Eser, Hale Yapıcı, additional, Kaçar, Murat, additional, Çakır, Mahmut, additional, Karatepe, Hasan Turan, additional, Işık, Ümit, additional, Kara, Halil, additional, Yeloğlu, Çağdaş Hünkar, additional, Yazıcı, Esra, additional, Gündüz, Anıl, additional, Karataş, Kader Semra, additional, Yavlal, Figen, additional, Uzun, Necati, additional, Yazici, Ahmet Bulent, additional, Bodur, Şahin, additional, Aslan, Esma Akpınar, additional, Batmaz, Sedat, additional, Çelik, Feyza, additional, Açıkel, Sadettin Burak, additional, Topal, Zehra, additional, Altunsoy, Neslihan, additional, Tulacı, Özge Demircan, additional, Demirel, Ömer Faruk, additional, Çıtak, Serhat, additional, Çak, Halime Tuna, additional, Artık, Abdül Baki, additional, Özçetin, Adnan, additional, Özdemir, Ilker, additional, Çelik, Fatma Gül Helvacı, additional, Kültür, Sadriye Ebru Çengel, additional, Çipil, Arif, additional, Ay, Rukiye, additional, Arman, Ayşe Rodopman, additional, Yazıcı, Kemal Utku, additional, Yuce, Arzu Erkan, additional, Yazıcı, İpek Perçinel, additional, Kurt, Emel, additional, Kaçar, Anıl Şafak, additional, Erbil, Nurhan, additional, Poyraz, Cana Aksoy, additional, Altın, Gamze Ergil, additional, Şahin, Berkan, additional, Kılıç, Özge, additional, Turan, Şenol, additional, Aydın, Memduha, additional, Kuru, Erkan, additional, Bozkurt, Abdullah, additional, Güleç, Hüseyin, additional, İnan, Merve Yalçınay, additional, Şevik, Ali Emre, additional, Baykal, Saliha, additional, Karaer, Yusuf, additional, Yanartaş, Omer, additional, Aksu, Hatice, additional, Ergün, Serhat, additional, Görmez, Aynur, additional, Yıldız, Mesut, additional, Bag, Sevda, additional, Özkanoğlu, Ferda Korkmaz, additional, Caliskan, Mecit, additional, Yaşar, Alişan Burak, additional, Konuk, Emre, additional, Altın, Murat, additional, Bulut, Serkut, additional, Bulut, Gresa Çarkaxhiu, additional, Tulacı, Rıza Gökçer, additional, Küpeli, Neşe Yorguner, additional, Enver, Necati, additional, Tasci, İlker, additional, Kani, Ayşe Sakallı, additional, Bahçeci, Bülent, additional, Oğuz, Gülay, additional, Şenyuva, Gülçin, additional, Ünal, Gülşen Teksin, additional, Yektaş, Çiğdem, additional, Örüm, Mehmet Hamdi, additional, Göka, Erol, additional, Gıca, Şakir, additional, Şahmelikoğlu, Özge, additional, Dinç, Gülser Şenses, additional, Erşan, Serpil, additional, Erşan, Erdal, additional, Ceylan, Mehmet Fatih, additional, Hesapçıoğlu, Selma Tural, additional, Solmaz, Mustafa, additional, Balcioglu, Yasin Hasan, additional, Cetin, Mesut, additional, Tosun, Musa, additional, Yurteri, Nihal, additional, Ulusoy, Sevinc, additional, Karadere, Mehmet Emrah, additional, Kivrak, Yüksel, additional, and Görmez, Vahdet, additional
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- 2018
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30. Oral Research Presentations
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Gürbüz, Hatice Gözde Akkın, primary, Turhan, Levent, additional, Şendil, Nilgun, additional, Kaşıkçı, Halim Ömer, additional, Salepçi, Banu, additional, Ipekcioglu, Derya, additional, Karcı, Canan Kuygun, additional, Ray, Perihan Çam, additional, Tahiroğlu, Ayşegül Yolga, additional, Avcı, Ayşe, additional, Çelik, Gonca Gül, additional, Cekin, Necmi, additional, Evliyaoğlu, Nurdan, additional, Alkanat, Mehmet, additional, Özdemir, Hafize, additional, Akgün, Egemen, additional, Demirkol, Mehmet Emin, additional, Tamam, Lut, additional, Esnafoglu, Erman, additional, Sevinçok, Doğa, additional, Memiş, Çağdaş Öykü, additional, Doğan, Bilge, additional, Çakaloz, Burcu, additional, Kutlu, Ayşe, additional, Sevinçok, Levent, additional, Dikmen, Sema Nur Türkoğlu, additional, Şafak, Yasir, additional, Gökçer Tulacı, Rıza, additional, Özdemir, İlker, additional, Baykara, Sema, additional, Alban, Kübra, additional, Aydın, Nazan, additional, Aytaç, Hasan Mervan, additional, Yılmaz, Doğan, additional, Aydın, Pınar Çetinay, additional, Yalçın, Gökşen Yüksel, additional, Canbay, Cana, additional, Terzioğlu, Merve, additional, Özer, Aysel, additional, Altintas, Ebru, additional, Kütük, Meryem Özlem, additional, Tufan, Ali Evren, additional, Bağ, Harika Gözükara, additional, Şenormancı, Güliz, additional, Güçlü, Oya, additional, Çelik, Cemil, additional, Bolu, Abdullah, additional, Öznur, Taner, additional, Aydın, Mehmet Sinan, additional, Tokgöz, Yusuf, additional, Uzun, Özcan, additional, Gıca, Sakır, additional, Poyraz, Burç Çağrı, additional, Fidan, Yağmur Sever, additional, Güleç, Hüseyin, additional, Akça, Erdoğdu, additional, Yıldız, Mesut, additional, Akça, Zeynep Nur Demirok, additional, Öztürk, Yusuf, additional, Özyurt, Gonca, additional, Özdel, Kadir, additional, Elboga, Gulcin, additional, Ozyurek, Muhammet Berkay, additional, Akgün, Abdullah, additional, Coşkun, Ali, additional, Bilgiç, Ayhan, additional, Sivri, Rukiye Çolak, additional, Kılınç, İbrahim, additional, İnal, Ahmet, additional, Eray, Uğur, additional, Acat, Murat, additional, Önder, Arif, additional, Adanır, Aslı Sürer, additional, Kavurma, Canem, additional, Bilaç, Öznur, additional, Doğan, Yakup, additional, Ay, Rukiye, additional, Uğur, Çağatay, additional, Alıç, Betül Gül, additional, Gündüz, Mehmet, additional, Ünal, Özlem, additional, Uçur, Ömer, additional, Özcan, Özlem, additional, Gül, Hasret Karabulut, additional, Aykut, Demet Sağlam, additional, Tiryaki, Ahmet, additional, Arslan, Filiz Civil, additional, Bülbül, Gül Alkan, additional, Yolcu, Ömer, additional, Uysal, Aysel, additional, Özatalay, Esin, additional, Cırrık, Selma, additional, Erdogan, Esin, additional, Delibas, Dursun Hakan, additional, Bozkurt, Hazan Tomar, additional, Tekdemir, Rukiye, additional, Erbasan, Vefa, additional, İmre, Okan, additional, Aydın, Memduha, additional, Altınbaş, Kürşat, additional, Karabucak, Başak, additional, Esen, Halime Tuna Çak, additional, Kültür, Sadriye Ebru Çengel, additional, Karaokur, Remzi, additional, Uysal, Songül Atasavun, additional, Erbil, Nurhan, additional, Kirazlı, Meltem Çiğdem, additional, Kara, Tayfun, additional, Mıhçıoğlu, Ajda Mutlu, additional, Yılmaz, Semra, additional, Akaltun, İsmail, additional, Atli, Abdullah, additional, Can, Zübeyir, additional, Çim, Emine Füsun Akyüz, additional, İbiloğlu, Aslıhan Okan, additional, Şahin, Nilfer, additional, Ertekin, Hülya, additional, Kocagöz, Zehra Başar, additional, Özçetin, Adnan, additional, Ataoğlu, Ahmet, additional, Cangür, Şengül, additional, Ölmez, Safiye Bahar, additional, Yazar, Neslihan, additional, Uçar, Halit Necmi, additional, Murat, Duygu, additional, Eray, Şafak, additional, Tanır, Yaşar, additional, Altun, Hatice, additional, Tanyeri, Mehmet Hanifi, additional, Büyükokuroğlu, Mehmet Emin, additional, Tanyeri, Pelin, additional, Mutlu, Oguz, additional, Akar, Füruzan Yıldız, additional, Ulak, Güner, additional, Erden, Bekir Faruk, additional, Sevgen, Feyza Hatice, additional, Arıcı, Asiye, additional, Kılıçaslan, Fethiye, additional, Erbay, Mehmet Fatih, additional, Darılmaz, Cengiz, additional, Çökmüş, Fikret Poyraz, additional, Yüzeren, Serra, additional, Dikici, Didem Sücüllüoğlu, additional, Aydın, Orkun, additional, Aydın, Pınar Ünal, additional, Akdeniz, Fatma, additional, Öztekin, Siğnem, additional, Çöldür, Emine Özge, additional, Balıkçı, Kuzeymen, additional, Köroğlu, Ertuğrul, additional, Aydemir, Ömer, additional, Kara, Hüseyin, additional, Özçelik, Özgen, additional, Balcı, Mehmet Murat, additional, Kuloğlu, Mehmet Murat, additional, Tomar, Talya, additional, Taneli, Fatma, additional, Oran, Arzu, additional, Ovalı, Gülgün Yılmaz, additional, Kaypaklı, Gamze Yapça, additional, Metin, Özge, additional, Karaş, Hakan, additional, Çetingök, Halil, additional, İlişer, Reşat, additional, Çarpar, Elif, additional, Kaşer, Muzaffer, additional, Can, Güneş Şayan, additional, Ulaş, Gözde, additional, Ildız, Ayşegül, additional, Emiroğlu, Neslihan, additional, Ada, Emel, additional, Özerdem, Ayşegül, additional, Imre, Okan, additional, Mutlu, Oğuz, additional, Akar, Furuzan Yıldız, additional, Tekin, Uğur, additional, Satar, Ayşegül, additional, Aydın, Ayşe Nur, additional, Erermiş, Hatice Serpil, additional, Kocaman, Orhan, additional, Çetin, Nihal Yurteri, additional, Akay, Aynur, additional, Karagöz, Yüksel Sümeyra, additional, Doğan, Özlem, additional, Ülkar, Serenay, additional, Kılıç, Birim Günay, additional, Ceyhun, Hacer Akgül, additional, Aydın, Esat Fahri, additional, Ülkevan, Tuba, additional, Gürbüzer, Nilifer, additional, Aykutlu, Hasan Cem, additional, Görker, Işık, additional, Özen, Emel, additional, Aktepe, Evrim, additional, Aydın, Mustafa Asım, additional, Yavuz, Dudu Dilek, additional, Karaaslan, Umut, additional, Karataş, Abdullah, additional, Sancak, Zehra, additional, Eser, Erhan, additional, Demet, Mehmet Murat, additional, Karadere, Mehmet Emrah, additional, Asafov, Ece Yazla, additional, Ölçüm, Halil İbrahim, additional, Algül, Ayhan, additional, Gündoğmuş, İbrahim, additional, Cetin, Fatih Hilmi, additional, Guler, Hasan Ali, additional, Turkoglu, Serhat, additional, Çolpan, Bahar Keleş, additional, Bayram, Elif, additional, Ateş, Funda Seher Özalp, additional, Teber, Serap Tıraş, additional, Duman, Nagihan Saday, additional, Gökten, Emel Sarı, additional, Sungur, Elif Nurgül, additional, Şengül, Melike Ceyhan Balcı, additional, Kardeşler, Ayşen Çetin, additional, Enli, Yaşar, additional, Kurtul, Neslihan, additional, Aslan, Cihan, additional, Konuşkan, Bahadır, additional, Şener, Burçin, additional, Anlar, Banu, additional, Ünal, Fatih, additional, Akçay, Bülent Devrim, additional, Koç, Güray, additional, Yetkin, Sinan, additional, Bayad, Serkan, additional, Elbir, Müge, additional, Topbaş, Özge Alp, additional, Kocabaş, Tuğba, additional, Aydın, Adem, additional, Avcu Çelik, Pelin, additional, Çıldır, Deniz Argüz, additional, Özbek, Aylin, additional, Mustan, Aybuke Tuğçe, additional, Karadağ, Ayşe Sevgi, additional, Kalenderoğlu, Aysun, additional, Örüm, Mehmet Hamdi, additional, Özen, Murat Eren, additional, Eğilmez, Oğuzhan Bekir, additional, Hamdi Örüm, Mehmet, additional, Aydın, Dilek Bingöl, additional, Elmas, Bahri, additional, Nasıroğlu, Serhat, additional, Aydın, Engin, additional, Özdemir, Öner, additional, Erel, Özcan, additional, Fedai, Ülker, additional, Asoğlu, Mehmet, additional, Elbay, Rümeysa Yeni, additional, Karatepe, Hasan Turan, additional, Ulaşoğlu, Celal, additional, Ayaydın, Hamza, additional, Şahin, Berkan, additional, Karabekiroğlu, Koray, additional, Bozkurt, Abdullah, additional, Usta, Miraç Barış, additional, Aydın, Muazzez, additional, Çobanoğlu, Cansu, additional, Kahya, Yalçın, additional, İnan, Dilara, additional, Altınöz, Ali Ercan, additional, Köşger, Ferdi, additional, Eşsizoğlu, Altan, additional, Arslan, Mehmet, additional, Çalışkan, Ali Metehan, additional, Göktaş, Duygu, additional, İnanlı, İkbal, additional, Çalışır, Saliha, additional, Eren, İbrahim, additional, Tatar, Zeynep Baran, additional, Kurt, Erhan, additional, Unal, Gokhan, additional, Aricioglu, Feyza, additional, Tezcan, Mustafa Esad, additional, Kalyoncu, Tuğba, additional, Ergüvendi, Fazilet, additional, Yektaş, Çigdem, additional, Eroz, Recep, additional, Yurdakul, Gokhan, additional, Cakır, Mahmut, additional, Tasmektepligil, Mehmet Yalcin, additional, Baykal, Saliha, additional, Usta, Mirac Barıs, additional, Karakurt, Melih Nuri, additional, Karabekiroglu, Koray, additional, Yulaf, Yasemin, additional, Gümştaş, Funda, additional, Gökçe, Sebla, additional, Yazgan, Yankı, additional, Sevincok, Doğa, additional, Kalyoncu, Tugba, additional, Ergüvendi, Fazilet Arkat, additional, Yağcı, İbrahim, additional, Avcı, Sema, additional, Kıvrak, Yüksel, additional, Yaşar, Alişan Burak, additional, Sayman, Ceyhun, additional, Taycan, Serap Erdoğan, additional, Çetinkaya, Yılmaz, additional, Gündüz, Anıl, additional, Tireli, Hülya, additional, Yazici, Kemal Utku, additional, Yazici, Ipek Percinel, additional, Kılıçle, Pınar Aksu, additional, Gül, Süleyman, additional, Yazici, Ipek Percınel, additional, Sümer, Ayçin Darıcı, additional, Çöp, Esra, additional, Bilgili, Duygu, additional, Şahin, Müge, additional, Dinç, Gülser Şenses, additional, Hekim, Özlem, additional, Mısırlıoğlu, Emine Dibek, additional, Kurt, Funda, additional, Göker, Zeynep, additional, Üneri, Özden, additional, Atalay, Eray, additional, Yıldırım, İrem, additional, İnaltekin, Ali, additional, Yücens, Bengü, additional, Kotan, Vahap Ozan, additional, Özkayar, Nihal, additional, Dede, Fatih, additional, Yüksel, Rabia Nazik, additional, Bayram, Şenol, additional, Kotan, Zeynep, additional, Göka, Erol, additional, Say, Gökçe Nur, additional, Kalyoncu, Merve, additional, Beğinoğlu, Özlem, additional, Basgoz, Bahadir Bilgin, additional, Ince, Semra, additional, Safer, Umut, additional, and Tasci, İlker, additional
- Published
- 2018
- Full Text
- View/download PDF
31. Psychogenic polydipsia associated with sertraline treatment: a case report
- Author
-
Okyar, Esra, primary, Bozatlı, Leyla, additional, Görker, Işık, additional, and Okyar, Serap, additional
- Published
- 2018
- Full Text
- View/download PDF
32. Antinuclear, Cytoskeletal, Antineuronal Antibodies in the Serum Samples of Children with Tic Disorders and Obsessive Compulsive Disorders
- Author
-
GÖRKER, İşık, DEMİR, Gülşen Akman, POLAT, Nuray Gürel, ÖMEROĞLU, Rukiye Eker, İÇÖZ, Sema, SERDAROĞLU, Piraye, and TÜZÜN, Ümran
- Subjects
PANDAS ,child ,Tic disorders ,Health Care Sciences and Services ,obsessive compulsive disorder ,mental disorders ,autoimmunity ,lcsh:R ,lcsh:Medicine ,Tic disorders,obsessive compulsive disorder,PANDAS,autoimmunity,child ,Sağlık Bilimleri ve Hizmetleri - Abstract
Objective: As environmental factors, the role of Group A beta hemolytic streptococcus infections in the development of tic and obsessive compulsive disorders (OCD) is controversial. The autoimmune hypothesis states that during infection, formation of autoantibodies leads to an autoimmune disorder, which in turn results in movement disorders, tic disorders and/or OCD. In order to test this hypothesis, we assayed these antibodies in children and adolescents diagnosed with tic disorders and/or OCD. Material and Methods: Children and adolescents who were diagnosed with either tic disorders or OCD according to DSM-IV criteria (n=28), were compared with healthy controls (n=15) having similar age and gender characteristics. Regardless of a streptococcus infection history, serum samples of all patients and controls underwent antinuclear, cytoskeletal, and antineuronal antibody assay using indirect immunofluorescence. Results: The rates of antinuclear antibody positivity were 21% and 20% in the patient and control groups respectively (p>0.05). Antineuronal antibody was positive in 2 (7%) of 28 patients versus in 1 (6%) of 15 controls (p>0.05). Conclusion: These results suggest that such antibodies may not be involved in the pathogenesis of tic disorders/OCD.
- Published
- 2011
33. 3.12 The Epidemiology of Childhood Psychopathology in Turkey: The Epicpat-T Study
- Author
-
Ercan, Eyup Sabri, primary, Tural, Umit, additional, Tufan, Evren, additional, Ozturk, Mücahit, additional, Karacetin, Gul, additional, Hergüner, Sabri, additional, Arman, Ayşe, additional, Kılıç, Birim Günay, additional, Toros, Fevziye, additional, Ünal, Fatih, additional, Kılınçaslan, Ayşe, additional, Coskun, Murat, additional, Fiş, Neşe Perdahlı, additional, and Görker, Işık, additional
- Published
- 2017
- Full Text
- View/download PDF
34. Association between Beta-Sympathomimetic Tocolysis and Risk of Autistic Spectrum Disorders, Behavioural and Developmental Outcome in Toddlers
- Author
-
Altay, Mengühan Araz, primary, Görker, Işık, additional, Aslanova, Rakhshanda, additional, Bozatlı, Leyla, additional, Turan, Nesrin, additional, and Kaplan, Petek Balkanlı, additional
- Published
- 2017
- Full Text
- View/download PDF
35. Selektif mutismin tedavisinde SSRI’ ların kullanımı
- Author
-
Çöpür, Mazlum, Görker, Işık, and Demir, Türkay
- Subjects
children ,Health Care Sciences and Services ,escitalopram ,mental disorders ,lcsh:R ,lcsh:Medicine ,citalopram ,Selective mutism,children,escitalopram,citalopram ,Sağlık Bilimleri ve Hizmetleri ,Selective mutism ,behavioral disciplines and activities ,Cerrahi - Abstract
Some authors suggest that selective mutism should be considered as a variant of social phobia or a disorder in the obsessive-compulsive spectrum. Recent studies indicate that pharmacological treatments may be effective in the treatment of selective mutism. In this article, four cases who were treated with citalopram and escitalopram are presented. The results indicate that the drugs were well tolerated, and the level of social and verbal interactions improved significantly. These findings have shown that citalopram and escitalopram can be considered in medication of selective mutism; nevertheless, it is essential that research be done with more cases than previous ones, in order to prove their accuracy Turkish Başlık: Selektif Mutismin Tedavisinde SSRI' ların Kullanımı Anahtar Kelimeler: Selektif mutism, çocuklar, essitalopram, sitalopram Bazı yazarlar selektif mutismin, sosyal fobinin bir varyantı olduğunu veya obsesif kompulsif bozukluk spektrumu içinde yer aldığını ileri sürmektedirler.Son yapılan çalışmalar selektif mutismin tedavisinde ilaçların etkili olabileceğini göstermektedir.Bu makalede sitalopram ve essitalopram ile tedavi edilen dört elektif mutism olgusu sunulmaktadır. Sonuçlar, bu iki ilacın olgularca iyi tolere edildiğini, verbal ve sosyal etkileşimin geliştiğini göstermiştir. Bu veriler sitalopram ve essitalopramın, selektif mutismin farmakolojik tedavisinde dikkate alınabileceğini düşündürmekle birlikte, daha net bilgiler elde etmek için geniş hasta gruplarında yeni çalışmaların yapılması gerekir..
- Published
- 2014
36. İleri derecede erken doğmuş yenidoğanların düzeltilmiş 1 3 yaşlarındaki nörogelişimsel ve psikiyatrik değerlendirmesi
- Author
-
Görker, Işık and Acunaş, Betül
- Subjects
Erken doğmuş bebek,ileri derecede erken doğmuş bebek,nörogelişim,psikiyatrik değerlendirme ,Health Care Sciences and Services ,Sağlık Bilimleri ve Hizmetleri - Abstract
Aim: To assess the neurodevelopmental and psychiatric outcomes of very preterm vs preterm infants at 1 3 years of corrected age Material and Method: Between years 2005 2008 premature infants followed up in the NICU designated as Group 1 lt;32 wks;n=36 were evaluated in comparison to Group 2 33 37wks; n=56 with the approval of Ethics Committee TUTFEK 2008 083 in terms of neurodevelopmental and psychiatric development by using Denver developmental screening test the brief infant toddler social emotional assessment childcare provider version Mothers rsquo; psychiatric symptoms were assessed by the brief symptom inventory Socioeconomic status was determined by using SES scale t test or Mann Whitney U tests chi square and Spearman tests were used for statistical analysis Results: In Group 1 paternal education level and psychodevelopmental score was lower than group 2 abnormal outcome in Denver developmental test was more frequent Psychiatric problem score was higher in boys whereas psychodevelopmental score was higher in girls Psychosocial developmental score was lower in those infants with intraventricular hemorrhage and this score showed positive correlation with Denver developmental test results There was no difference between the two groups in terms of brief symptom inventory Conclusions: Although very preterm infants more frequently showed abnormal neuropsychological development they were not significantly different with regard to psychiatric problems Girls were more advantegous than boys in terms of psychodevelopment We conclude that these findings should be validated by larger and further studies Turk Arch Ped 2011; 46: 280 5, Amaç: İleri derecede erken doğmuş yenidoğanlarla orta derecede ve sınırda erken doğmuş yenidoğanların düzeltilmiş 1 3 yaşlarındaki gelişimsel ve psikiyatrik değerlendirme sonuçlarının karşılaştırılması. Gereç ve Yöntem: 2005 2008 tarihleri arasında Yenidoğan Birimi rsquo;nde izlenen grup 1 lt;32 gebelik haftası;n=36 ve grup 2 rsquo;deki 33 37 gebelik haftası; n=56 yenidoğanlar Etik Kurul onayı alınarak TÜTFEK 2008 083 düzeltilmiş 13 yaşlarındaki Denver gelişimsel testi ve kısa 1 3 yaş sosyal duygusal değerlendirme ölçeği ile gelişimsel sosyal duygusal ve psikiyatrik sorunlar yönünden değerlendirildi Annelerine kısa semptom envanteri uygulandı Ailelerin sosyoekonomik durumu sosyo ekonomik durum ölçeğiyle belirlendi İstatistiksel analizde t testi veya Mann Whitney U testi ki kare ve Spearman testi kullanıldı Bulgular: Grup 1 rsquo;de baba eğitim düzeyi psikogelişimsel skor ortalaması grup 2 rsquo;ye göre daha düşük anormal Denver gelişim test oranı daha yüksek saptandı Psikiyatrik sorun skoru erkeklerde psikososyal gelişim skoru ise kızlarda daha yüksekti Psikososyal gelişim skoru ventrikül içine kanaması olanlarda daha düşüktü ve bu skor ile Denver gelişim tesiti arasında pozitif ilişki saptandı Kısa semptom envanteri açısından farklılık yoktu.Çıkarımlar: İleri derecede erken doğmuş yenidoğanlar daha sık anormal nöropsikolojik gelişim gösterdikleri halde psikiyatrik sorun açısından farklı bulunmadılar Psikogelişimsel yönden kızlar erkeklere göre daha önde idi Bu bulguların daha geniş ve ileri çalışmalarla desteklenmesi gerektiği sonucuna varıldı.
- Published
- 2014
37. Investigation of Copy Number Variation by arrayCGH in Turkish Children and Adolescents Diagnosed with Autism Spectrum Disorders.
- Author
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Görker, Işık, Gürkan, Hakan, Ulusal, Selma, Atli, Engin, Ayaz, Güçlü, Ceylan, Cansın, Tozkir, Hilmi, Araz Altay, Mengühan, Erol, Ali, Yildiz, Nazike, Direk, Ceren, Akköprü, Hilal, Kilit, Neriman, Aykutlu, Hasan Cem, Bozatli, Leyla, Çelik, Zeki, and Berberoğlu, Kıvanç Kudret
- Subjects
- *
DIAGNOSIS of autism , *GENETICS , *KARYOTYPES , *NUCLEIC acid hybridization - Abstract
Aim: The development of whole-genome screening methodologies for the detection of copy number variations (CNVs), such as array-based comparative genomic hybridization (aCHG), provides a much higher resolution than karyotyping leading to the identification of novel microdeletion and microduplication syndromes often associated with an autism spectrum disease (ASD) phenotype. The aim of the study was to determine CNVs of patients with ASD by using array-based comparative genomic hybridization. Methods: Fifty-three patients diagnosed with ASD between 20.01.2014 and 14.01.2015 were included in the study. Chromosome analysis of the patients was performed from peripheral blood cultures and analysed as normal. All patients were evaluated with P064C1 and P096A2 MLPA probes in terms of 16 mental retardation related syndromes. For aCGH method, SurePrint G3 Human microarrays 8x60K were used with genomic DNA isolated from peripheral blood. Results: According to results of 53 patients who were included in and performed with arrayCGH, 8 (15%) patients had CNVs classified as pathogenic or variant of unknown significance (VOUS) in the study. We detected a pathogenic NRXN1 gene partial CNV deletion (2p16.3) in two patients. Also we identified a 900 kb duplication of 4p15.31 including SLIT2 gene, and a 245 kb duplication of 15q11.2 including PWRN1 gene in one patient. Our other findings are considered to be a variant of unknown significance (VOUS). Conclusion: The results of the study support the literature knowledge, where the copy number variations that cannot be detected with conventional cytogenetics methods in terms of size may happen in patients with ASD. [ABSTRACT FROM AUTHOR]
- Published
- 2018
- Full Text
- View/download PDF
38. DSM-5 Kriterlerine Göre Özgül Öğrenme Bozukluğu Tanısı Alan Olguların Psikiyatrik Eştanı ve WISC-R Profillerinin Değerlendirilmesi.
- Author
-
ARAZ ALTAY, Mengühan and GÖRKER, Işık
- Subjects
- *
DIAGNOSIS of learning disabilities , *PSYCHIATRIC diagnosis , *ACALCULIA , *ATTENTION-deficit hyperactivity disorder , *CHILD psychopathology , *COGNITION , *ENURESIS , *CLASSIFICATION of mental disorders , *PHOBIAS , *READING disability , *TIC disorders , *COMORBIDITY ,WRITING - Abstract
Introduction: In this study, the frequency of psychiatric comorbidity in children and adolescents who were diagnosed with specific learning disorder, the factors that affect the frequency of comorbidity, the subtypes of specific learning disorder and the effects on cognitive profile have been investigated. Methods: Our study was performed among 80 cases with the age range 6-15 years who diagnosed with specific learning disorder Child and Adolescent Psychiatry Department between January and June 2015. In the study, DSM-IV Based Screening and Evaluation Scale for Child and Adolescent Behavioral Disorders, Specific Learning Disability Evaluation Scale and the WISC-R test were performed. During the interview, reading-writing-math abilities evaluation list (error analysis) was performed in order to define the specific learning disorder subgroup and to evaluate the detailed error profile of the specific learning disorder subgroup. Kiddie Schedule for Affective Disorders and Schizophrenia for School-age Children-Present and Lifetime Turkish Version (KSADS) was performed to detect psychiatric comorbidity diagnoses. Results: 92.5% of the cases have a comorbid psychiatric disorder. The most frequent psychiatric comorbidity was attention deficit hyperactivity disorder (82.3%), followed by specific phobia (46.3%), oppositional defiant disorder (26.3%), enuresis (25%) and tic disorders (22.5%). Psychiatric comorbidity is detected more often in patients with specific learning disorder accompanied by attention deficit and hyperactivity disorder. The most frequent subtype of specific learning disorder is combined type disorder consisting of reading, writing and math disorder (37.5%). The WISC-R score of the patients who had math disorder were found to be lower than the others, and also it was detected that they learned reading and writing later, and have more comorbid psychiatric disorders. Conclusion: The results of our study indicate that associated psychiatric disorders are frequent with specific learning disorder. Specific learning disorder should not be considered as a single disorder, but should be assessed and treated with comorbid psychiatric disorders. [ABSTRACT FROM AUTHOR]
- Published
- 2018
- Full Text
- View/download PDF
39. The Probable Prevalence and Sociodemographic Characteristics of Specific Learning Disorder in Primary School Children in Edirne.
- Author
-
GÖRKER, Işık, BOZATLI, Leyla, KORKMAZLAR, Ümran, YÜCEL KARADAĞ, Meltem, CEYLAN, Cansın, SÖĞÜT, Ceren, AYKUTLU, Hasan Cem, SUBAY, Büşra, and TURAN, Nesrin
- Subjects
- *
LEARNING disabilities , *NEONATAL jaundice , *READING disability , *LOGISTIC regression analysis , *SOCIOECONOMIC factors , *CHILDREN , *DISABILITIES ,WRITING - Abstract
Introduction: The aim of this study was to research the probable prevalence of Specific Learning Disorder (SLD) in primary school children in Edirne City and the relationships with their sociodemographic characteristics. Methods: The sample of our study was composed of 2,174 children who were educated in primary schools in second, third, and fourth grades in the academic year 2013-2014 in Edirne City. The teachers and parents of these children were given Specific Learning Difficulties Symptom Scale, Learning Disabilities Symptoms Checklist (teacher and parent forms), and sociodemographic data forms to fill in. Binary logistic regression analysis was used to assess the risk factors for SLD. Results: Our study revealed that the probable prevalence of SLD was 13.6%; 17% for boys and 10.4% for girls. Reading impairment was 3.6%, writing impairment was 6.9%, and mathematic impairment was 6.5%. We determined that consanguineous marriages, low income, history of neonatal jaundice were found as risks for SLD; born by caesarean, developmental delay of walking, and history of neonatal jaundice were found as risks for mathematic impairment. A history of learning difficulties of parents was a risk factor for forming SLD and subtypes. Conclusion: Our findings were consistent with other study results about the prevalence of SLD. The relationships between the probable prevalence rates and sociodemographic data were discussed. [ABSTRACT FROM AUTHOR]
- Published
- 2017
- Full Text
- View/download PDF
40. Psychogenic polydipsia associated with sertraline treatment: a case report.
- Author
-
Okyar, Esra, Bozatlı, Leyla, Görker, Işık, and Okyar, Serap
- Published
- 2019
- Full Text
- View/download PDF
41. Başlık İleri Derecede Prematüre Yenidoğanların Düzeltilmiş 1-3 Yaşında Nörogelişimsel ve Psikiyatrik Değerlendirmesi
- Author
-
Görker, Işık, primary, Vatansever, Ülfet, additional, and Acunaş, Betül, additional
- Published
- 2011
- Full Text
- View/download PDF
42. İleri derecede erken doğmuş yenidoğanların düzeltilmiş 1-3 yaşlarındaki nörogelişimsel ve psikiyatrik değerlendirmesi
- Author
-
Görker, Işık, primary, Vatansever, Ülfet, additional, and Acunaş, Betül, additional
- Published
- 2011
- Full Text
- View/download PDF
43. Effect of neonatal resuscitation courses on long-term neurodevelopmental outcomes of newborn infants with perinatal asphyxia
- Author
-
Duran, Rıdvan, primary, Görker, Işık, additional, Küçükuğurluoğlu, Yasemin, additional, AladağÇiftdemir, Nükhet, additional, Vatansever Özbek, Ülfet, additional, and Acunaş, Betül, additional
- Published
- 2011
- Full Text
- View/download PDF
44. PP-100. The effect of the neonatal resuscitation program courses on the long-term neurodevelopmental outcome of newborn infants with perinatal asphyxia
- Author
-
Duran, Ridvan, primary, Görker, Işık, additional, Küçükuğurluoğlu, Yasemin, additional, Ciftdemir, Nukhet Aladag, additional, Ozbek, Ulfet Vatansever, additional, and Acunas, Betul, additional
- Published
- 2010
- Full Text
- View/download PDF
45. Serotonin-Selective Reuptake Inhibitor-Induced Enuresis in Three Pediatric Cases
- Author
-
Hergüner, Sabri, primary, Kılınçaslan, Ayşe, additional, Görker, Işık, additional, and Tüzün, Ümran, additional
- Published
- 2007
- Full Text
- View/download PDF
46. Relationship between Psychiatric Symptoms in Expectant Parents and Postpartum Depression and Infantile Colic: a Multicenter Follow-up Study.
- Author
-
ÇAK, H. Tuna, KARABEKİROĞLU, Koray, KÜLTÜR, Ebru ÇENGEL, TARAKÇIOĞLU, Mahmut Cem, KAYA, Rahime, SAY, Gökçe Nur, GÖRKER, Işık, SAPMAZ, Dicle, KARABEKİROĞLU, Aytül, MEMİK, Nursu ÇAKIN, YÜCE, Murat, KÖSE, Sezen, ÖZBARAN, Burcu, ÖZDEMİR, Dilşad FOTO, SARI, Burcu AKIN, EROL, Serpil ÖZKOÇ, EVİNÇ, Gülin, CENGİZ, Hakan, and VAROL, Füsun
- Subjects
MENTAL illness ,EXPECTANT parents ,POSTPARTUM depression ,INFANTILE colic ,SOCIAL support ,FOLLOW-up studies (Medicine) ,EDINBURGH Postnatal Depression Scale - Abstract
Objective: The aim of this study is to evaluate the relationship between postpartum depression (PPD), infantile colic (IC) and different psychosocial variables, psychiatric symptoms, attachment style and perceived social support in expectant parents. Method: Two hundred forty-five expectant mothers and 150 expectant fathers were first interviewed between 22 and 34 weeks of pregnancy. Each expectant parent filled out a sociodemographic data form, Adult Attachment Style Scale (AASS), State Anxiety Inventory (SAI), Edinburgh Postnatal Depression Scale (EPDS), Multidimensional Scale of Perceived Social Support (MSPSS) and Brief Symptom Inventory (BSI. A second interview was conducted between 4 and 24 weeks postpartum. The mothers filled out a data form consisting of health, nutrition, sleep, and crying problems of the infant, as well as EPDS and SAI, while fathers filled out SAI. Results: One in every four mothers had PPD symptoms above the threshold on EPDS. Maternal and paternal insecure attachment style, maternal psychiatric symptoms, and postpartum anxiety level were found to be the predictors of PPD. One of every five infants had IC, and maternal education level, hostility score, and PPD symptoms, along with paternal insecure attachment style and psychiatric symptoms, were the main predictors of IC. Conclusion: Results about PPD and IC regarding maternal variables are consistent with the literature. In addition, paternal insecure attachment style was found to be an important risk factor for both PPD and IC. Fathers should also be included in further studies exploring PPD or IC. [ABSTRACT FROM AUTHOR]
- Published
- 2015
47. Selective Serotonin Reuptake Inhibitors for Treatment of Selective Mutism.
- Author
-
Çöpür, Mazlum, Görker, Işık, and Demir, Türkay
- Subjects
- *
SEROTONIN uptake inhibitors , *MUTISM , *HEALTH outcome assessment , *TREATMENT effectiveness , *CITALOPRAM - Abstract
Some authors suggest that selective mutism should be considered as a variant of social phobia or a disorder in the obsessive-compulsive spectrum. Recent studies indicate that pharmacological treatments may be effective in the treatment of selective mutism. In this article, four cases who were treated with citalopram and escitalopram are presented. The results indicate that the drugs were well tolerated, and the level of social and verbal interactions improved significantly. These findings have shown that citalopram and escitalopram can be considered in medication of selective mutism; nevertheless, it is essential that research be done with more cases than previous ones, in order to prove their accuracy [ABSTRACT FROM AUTHOR]
- Published
- 2012
- Full Text
- View/download PDF
48. Effect of neonatal resuscitation courses on long-term neurodevelopmental outcomes of newborn infants with perinatal asphyxia.
- Author
-
Duran, Rıdvan, Görker, Işık, Küçükuğurluoğlu, Yasemin, AladağÇiftdemir, Nükhet, Vatansever Özbek, Ülfet, and Acunaş, Betül
- Subjects
- *
CEREBRAL palsy , *SEIZURES diagnosis , *SPASMS , *ASPHYXIA , *DEVELOPMENTAL disabilities , *ANALYSIS of variance , *BRAIN injuries , *CHI-squared test , *CARDIOPULMONARY resuscitation , *ELECTROENCEPHALOGRAPHY , *GOODNESS-of-fit tests , *LONGITUDINAL method , *STATISTICS , *DATA analysis , *REPEATED measures design , *DATA analysis software , *DESCRIPTIVE statistics , *DIAGNOSIS , *THERAPEUTICS , *DISABILITIES - Abstract
Background: In previous studies, it has been demonstrated that Neonatal Resuscitation Program (NRP) courses improve the early outcomes of infants with perinatal asphyxia, but there has been no evidence to demonstrate the effect of NRP on long-term outcomes of perinatal asphyxia. The goal of the present study was to determine the effect of NRP courses on the long-term neurodevelopmental outcome of perinatal asphyxia. Methods: This prospective study included infants referred to the Neonatal Unit during the years 2003-2005. Those patients who were referred before NRP courses (pretraining period) were designated as group 1, those who were referred after the first NRP course (transition period) as group 2, and those who were referred after the second NRP course (post-training period) as group 3. Neurodevelopmental outcomes were assessed and compared at 4-6 years of age. Results: The study involved 40 patients: 23 in group 1, nine in group 2 and eight in group 3. The number of patients who had been diagnosed with cerebral palsy was 13 in group 1, two in group 2, and one in group 3, which was a significant decrease. The number of patients with seizures and electroencephalography abnormality was 12 and 14 in group 1, three and two in group 2, and one and one in group 3, respectively, which was also a significant decrease. Conclusions: NRP courses have positive effects on short-term as well as long-term neurodevelopmental outcomes of infants with perinatal asphyxia. Further studies are required to determine the effects of NRP courses on minor deficits, such as cognitive and behavioral disturbances. [ABSTRACT FROM AUTHOR]
- Published
- 2012
- Full Text
- View/download PDF
49. Improvement of stuttering with use of methylphenidate in a child who was diagnosed with concomitant stuttering and ADHD.
- Author
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BOZATLI, Leyla, BERBEROĞLU, Kıvanç Kudret, CEYLAN, Cansın, and GÖRKER, Işık
- Abstract
Copyright of Anatolian Journal of Psychiatry / Anadolu Psikiyatri Dergisi is the property of Anatolian Journal of Psychiatry and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2016
- Full Text
- View/download PDF
50. Arka Çukur Cerrahi Girişimi Sonrası Serebellar Mutizm Olgusu.
- Author
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GÖRKER, Işık, ÇOBANOĞLU, Sabahattin, and ŞAN, Volkan
- Subjects
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BRAIN tumors , *NEUROLOGICAL disorders , *SURGICAL complications , *POSTERIOR cranial fossa , *SURGERY ,COMPLICATIONS - Abstract
Cerebellar mutism consisting of disruption speech output, hypotonia, ataxia, and emotional lability occurs after surgery for posterior fossa tumors. Although the mutism is transient, speech rarely normalizes and this condition is associated with adverse neurological, cognitive and psychiatric abnormalities. Possible mechanisms for its etiology include direct injury from surgical trauma, vasospasm, edema and hydrocephalus causing delayed injury to the cerebellar vermis, brainstem and dentate nuclei. In this study, the case of an adolescent patient, who had an astrocytoma and showed symptoms of cerebellar mutism, apathy, ataxi, hemiparesis and visual impairment after posterior fossa surgery, is presented. [ABSTRACT FROM AUTHOR]
- Published
- 2012
- Full Text
- View/download PDF
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