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2 results on '"Gökçe Canan Taşkın"'

1. Phthalocyanine-chalcone conjugates

Author

Fallia Aribi, Jérémie Fournier-dit-Chabert, Sebile Işık Büyükekşi, Khalil Bennis, Derya Topkaya, Ayşe Gül Gürek, Vefa Ahsen, Devrim Atilla, Charlene Vey, Gökçe Canan Taşkın, Mélissa Cucca, Florian Albrieux, Sinem Tuncel Kostakoğlu, Sylvie Ducki, Serkan Alpugan, Fabienne Dumoulin, Department of chemistry - Gebze Technical University, Gebze Teknik Üniversitesi [Gebze], Institut de Chimie de Clermont-Ferrand (ICCF), Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-SIGMA Clermont (SIGMA Clermont)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Centre Commun de Spectrometrie de Masse (CCSM), Institut de Chimie et Biochimie Moléculaires et Supramoléculaires (ICBMS), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut de Chimie du CNRS (INC)-École Supérieure Chimie Physique Électronique de Lyon-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut de Chimie du CNRS (INC)-École Supérieure Chimie Physique Électronique de Lyon-Centre National de la Recherche Scientifique (CNRS), Université de Lyon-Université de Lyon-École Supérieure de Chimie Physique Électronique de Lyon (CPE)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), and Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)

Subjects
Chalcone, 010405 organic chemistry, Chemistry, photosensitizer, medicine.medical_treatment, chalcone, Photodynamic therapy, vascular disruption, General Chemistry, 010402 general chemistry, Grafting, Photochemistry, 01 natural sciences, 0104 chemical sciences, chemistry.chemical_compound, phthalocyanine, photodynamic therapy, medicine, Phthalocyanine, [CHIM]Chemical Sciences, Photosensitizer, Conjugate
Abstract

International audience; A phthalocyanine-chalcone conjugate was previously reported to retain the full photodynamic activity of the phthalocyanine and a slightly lowered antivascular effect of the chalcone. Assuming that it was due to an insufficient release of the chalcone, we described here several grafting modes applied to the preparation of phthalocyanine-chalcone conjugates.

Published
2016
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2. Axially Paraben Substituted Silicon(Iv) Phthalocyanines Towards Dental Pathogen Streptococcus Mutans: Synthesis, Photophysical, Photochemical And In Vitro Properties

Author

Vesselin Kussovski, Vanya Mantareva, Gökçe Canan Taşkın, Ivan Angelov, Fatma Yuksel, Mahmut Durmuş, and Devrim Atilla

Subjects
biology, Methylparaben, Chemistry, Singlet oxygen, General Chemical Engineering, General Physics and Astronomy, General Chemistry, Photochemistry, biology.organism_classification, Streptococcus mutans, Paraben, chemistry.chemical_compound, Phthalocyanine, Ethylparaben, Photodegradation, Propylparaben
Abstract

A series of silicon(IV) phthalocyanines axially substituted with methylparaben, ethylparaben, propylparaben and butylparaben groups were synthesized and studied as photosensitizers for antimicrobial photodynamic therapy. The absorption, fluorescence, photodegradation and singlet oxygen generation properties of the synthesized Si(IV) phthalocyanines were studied. In vitro antibacterial photodynamic therapy was investigated against cariogenic pathogenic bacterium Streptococcus mutans. Axially propylparaben substituted Si(IV) phthalocyanine showed significant photodynamic efficacy (log 4) at concentration of 10 mu M and mild irradiation (60 mW cm(-2), 50J cm(-2), LED 637 nm). The low inactivation capacity was observed for the other studied Si(IV) phthalocyanines. The uptake and localization properties of axially propylparaben substituted Si(IV) phthalocyanine showed a sufficient level of accumulation in planktonic cultured bacterium and a complete penetration depth into the biomass of the 48-h bacterial biofilm. (C) 2015 Elsevier B.V. All rights reserved.

Published
2015

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