104 results on '"Gómez-Peralta F"'
Search Results
2. Assessment of frailty in the person with type 2 diabetes mellitus: Expert analysis
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Romera-Liebana, L., Urbina-Juez, A., Micó-Pérez, R.M., Mediavilla Bravo, J.J., Marco Martinez, A., Gómez-Peralta, F., Cubo-Romano, P., and Formiga, F.
- Published
- 2023
- Full Text
- View/download PDF
3. Valoración de la fragilidad en la persona con diabetes mellitus tipo 2: análisis de expertos
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Romera-Liebana, L., Urbina-Juez, A., Micó-Pérez, R.M., Mediavilla Bravo, J.J., Marco Martinez, A., Gómez-Peralta, F., Cubo-Romano, P., and Formiga, F.
- Published
- 2023
- Full Text
- View/download PDF
4. Executive summary on the treatment of type 2 diabetes mellitus in elderly or frail individuals. 2022 update of the 2018 consensus document “Treatment of type 2 diabetes mellitus in the elderly”
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Gómez-Peralta, F., Carrasco-Sánchez, F.J., Pérez, A., Escalada, J., Álvarez-Guisasola, F., Miranda-Fernández-Santos, C., Mediavilla-Bravo, J.J., and Gómez-Huelgas, R.
- Published
- 2022
- Full Text
- View/download PDF
5. Resumen ejecutivo sobre el tratamiento de la diabetes mellitus tipo 2 en personas de edad avanzada o frágiles. Actualización 2022 del documento de consenso 2018 «Tratamiento de la diabetes mellitus tipo 2 en el paciente anciano»
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Gómez-Peralta, F., Carrasco-Sánchez, F.J., Pérez, A., Escalada, J., Álvarez-Guisasola, F., Miranda-Fernández-Santos, C., Mediavilla-Bravo, J.J., and Gómez-Huelgas, R.
- Published
- 2022
- Full Text
- View/download PDF
6. Evaluation of knowledge, barriers, and attitudes in the management of type 2 diabetes in elderly patients: A Delphi study on primary and hospital care
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Gómez-Huelgas, R., Gómez-Peralta, F., and Cos, F.X.
- Published
- 2022
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- View/download PDF
7. Evaluación de conocimientos, barreras y actitudes en el manejo de la diabetes tipo 2 en pacientes de edad avanzada: estudio Delphi en atención primaria y hospitalaria
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Gómez-Huelgas, R., Gómez-Peralta, F., and Cos, F.X.
- Published
- 2022
- Full Text
- View/download PDF
8. When does diabetes start? Early detection and intervention in type 2 diabetes mellitus
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Gómez-Peralta, F., Abreu, C., Cos, X., and Gómez-Huelgas, R.
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- 2020
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- View/download PDF
9. ¿Cuándo empieza la diabetes? Detección e intervención tempranas en diabetes mellitus tipo 2
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Gómez-Peralta, F., Abreu, C., Cos, X., and Gómez-Huelgas, R.
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- 2020
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- View/download PDF
10. Treatment of type 2 diabetes mellitus in elderly patients
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Gómez-Huelgas, R., Gómez Peralta, F., Rodríguez Mañas, L., Formiga, F., Puig Domingo, M., Mediavilla Bravo, J.J., Miranda, C., and Ena, J.
- Published
- 2018
- Full Text
- View/download PDF
11. Tratamiento de la diabetes mellitus tipo 2 en el paciente anciano
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Gómez-Huelgas, R., Gómez Peralta, F., Rodríguez Mañas, L., Formiga, F., Puig Domingo, M., Mediavilla Bravo, J.J., Miranda, C., and Ena, J.
- Published
- 2018
- Full Text
- View/download PDF
12. Valoración de la fragilidad en la persona con diabetes mellitus tipo 2: análisis de expertos
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Cubo-Romano, P., primary, Gómez-Peralta, F., additional, Formiga, F., additional, Romera-Liebana, L., additional, Mediavilla Bravo, J.J., additional, Marco Martinez, A., additional, Urbina-Juez, A., additional, and Micó-Pérez, R., additional
- Published
- 2023
- Full Text
- View/download PDF
13. Position statement of the SEMI, SED, redGDPS, SEC, SEEDO, SEEN, SEMERGEN y SEMFYC
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Gómez Huelgas, R., Gómez Peralta, F., Carrillo Fernández, L., Galve, E., Casanueva, F.F., Puig Domingo, M., Mediavilla Bravo, J.J., Orozco Beltrán, D., Ena Muñoz, J., Menéndez Torre, E., Artola Menendez, S., Mazón Ramos, P., Monereo Megías, S., Caixas Pedrágos, A., López Simarro, F., and Álvarez Guisasola, F.
- Published
- 2015
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- View/download PDF
14. Hacia un manejo integral del paciente con diabetes y obesidad. Posicionamiento de la SEMI, SED, redGDPS, SEC, SEEDO, SEEN, SEMERGEN y SEMFYC
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Gómez Huelgas, R., Gómez Peralta, F., Carrillo Fernández, L., Galve, E., Casanueva, F.F., Puig Domingo, M., Mediavilla Bravo, J.J., Orozco Beltrán, D., Muñoz, J. Ena, Menéndez Torre, E., Artola Menendez, S., Mazón Ramos, P., Monereo Megías, S., Caixas Pedrágos, A., López Simarro, F., and Álvarez Guisasola, F.
- Published
- 2015
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- View/download PDF
15. IDF2022-0312 Physical activity patterns in type 1 diabetes in Spain. The SED1 study
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Gomez-Peralta, F., Menéndez, E., Conde, S., Conget, I., and Novials, A.
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- 2023
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16. IDF2022-0315 Efficacy of the insulin pen cap Insulclock® in type 1 diabetes mellitus (T1DM): A multicenter, randomized clinical trial
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Gomez-Peralta, F., Abreu, C., Fernández-Rubio, E., Cotovad, L., Pujante, P., Gaztambide, S., Bellido, D., Menéndez-Torre, E., Ruiz-Valdepeñas, S., Bello, H., Valledor, X., and Pérez-González, J.
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- 2023
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17. POSA331 Patient Preferences for Diabetes Management in Spain - A Discrete Choice Experiment
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Muñoz, Á, primary, Gómez-Peralta, F, additional, Mareque, M, additional, Maderuelo, M, additional, and Casado, MÁ, additional
- Published
- 2022
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18. Executive summary: Position document: Evaluation and management of hypoglycemia in the patient with diabetes mellitus 2020. Diabetes Mellitus Working Group of the Spanish Society of Endocrinology and Nutrition
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Reyes-García R, Mezquita-Raya P, Moreno-Pérez Ó, Muñoz-Torres M, Merino-Torres JF, Márquez Pardo R, Jódar-Gimeno E, Escalada San Martín J, Gargallo-Fernández M, Soto-Gonzalez A, González Pérez de Villar N, Bellido Guerrero D, Gómez-Peralta F, de Luis Román D, López de la Torre Casares M, and Spanish Society of Endocrinology and Nutrition (SEEN)
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Diabetes mellitus ,Evidencia ,Hipoglucemia ,Hypoglycemia ,Evidence - Abstract
OBJECTIVE: To provide practical recommendations for the evaluation and management of hypoglycemia in patients with diabetes mellitus. PARTICIPANTS: Members of the Diabetes Mellitus Working Group of the Spanish Society of Endocrinology and Nutrition (SEEN). METHODS: The recommendations were made based on the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) system to establish both the strength of the recommendations and the level of evidence. A systematic search was made in MEDLINE (PubMed) for the available evidence on each subject, and articles written in English and Spanish with an inclusion date up to 30 November 2019 were reviewed. This executive summary takes account of the evidence incorporated since 2013. CONCLUSIONS: The document establishes practical evidence-based recommendations regarding the evaluation and management of hypoglycemia in patients with diabetes mellitus.
- Published
- 2021
19. 129TiP Metformin (MF) in the prevention of hyperglycemia (HG) in patients (pts) with PIK3CA-mutated, hormone receptor (HR)[+]/HER2[–] advanced breast cancer (ABC) treated with alpelisib (ALP) plus fulvestrant (F): METALLICA
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Llombart Cussac, A., primary, Pérez-Garcia, J.M., additional, Blanch, S., additional, Tolosa, P., additional, Ruiz Borrego, M., additional, Gion Cortes, M., additional, Fernádez, A., additional, Urruticoechea, A., additional, Galve, E., additional, Cueva Banuelos, J.F., additional, Ponce, J., additional, Alonso, J.L., additional, Capelán, M., additional, Martínez, E., additional, Bermejo De Las Heras, B., additional, Rojas, B., additional, Martos, T., additional, López, A., additional, Gómez-Peralta, F., additional, and Cortés, J., additional
- Published
- 2021
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20. Glycaemic control in patients with type 2 diabetes switching from premixed insulin to long-acting basal insulin analogue plus oral antidiabetic drugs: an observational study
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Gómez-Peralta, F., Carramiñana-Barrera, F., Félix-Redondo, F. J., and Fraile-Gómez, J.
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- 2012
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21. [Treatment of type 2 diabetes mellitus in elderly patients]
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Gómez-Huelgas R, Gómez Peralta F, Rodríguez Mañas L, Formiga F, Puig Domingo M, Mediavilla Bravo JJ, Miranda C, and Ena J
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musculoskeletal diseases ,Diabetes Mellitus, Type 2 ,Consensus Development Conferences as Topic ,Humans ,Algorithms ,Aged - Abstract
The prevalence of type 2 diabetes mellitus (DM2) increases markedly with age. Anti diabetic treatment and the objectives of glycaemic control in elderly patients with DM2 should be individualised according to their biopsychosocial characteristics. In elderly patients for whom the benefits of intensive antidiabetic treatment are limited, the basic objectives should be to improve the quality of life, preserve functionality and avoid adverse effects, especially hypoglycaemia. Treatment of DM2 in the elderly was the subject of a consensus document published in 2012 and endorsed by several Spanish scientific societies. Since then, new therapeutic groups and evidence have emerged that warrant an update to this consensus document. The present document focuses on the therapeutic aspects of DM2 in elderly patients, understood as being older than 75 years or frail. (C) 2017 Elsevier Espana, S.L.U. and Sociedad Espanola de Medicina Interna (SEMI). All rights reserved.
- Published
- 2018
22. Metformin-associated lactic acidosis, a ghost or a murderer?
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Gómez-Peralta, F., primary and Abreu, C., additional
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- 2019
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23. Acidosis láctica asociada a metformina, ¿un fantasma o un asesino?
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Gómez-Peralta, F., primary and Abreu, C., additional
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- 2019
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24. Tratamiento de la diabetes mellitus tipo 2 en el paciente anciano
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Gómez-Huelgas, R., primary, Gómez Peralta, F., additional, Rodríguez Mañas, L., additional, Formiga, F., additional, Puig Domingo, M., additional, Mediavilla Bravo, J.J., additional, Miranda, C., additional, and Ena, J., additional
- Published
- 2018
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- View/download PDF
25. Diabetes y cirugía II: Principios generales de tratamiento
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Santos, E., primary, Gómez Peralta, F., additional, and Salvador, J., additional
- Published
- 2017
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26. Diabetes y cirugía II: Principios generales de tratamiento
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Santos, E. (E.), Gómez-Peralta, F. (F.), Salvador, J. (J.), Santos, E. (E.), Gómez-Peralta, F. (F.), and Salvador, J. (J.)
- Abstract
El manejo terapéutico y de control metabólico del paciente diabético durante el acto quirúrgico posee una trascendencia esencial para reducir la posibilidad de desarrollo de complica- ciones. El mantenimiento de un adecuado estado de hidratación y la administración continua de insulina por vía intravenosa constituyen uno de los pilares básicos del tratamiento intraoperatorio. La posibilidad de variar las dosis de insulina a lo largo de la intervención justifica la necesidad de realizar controles frecuentes de glucemia. Algunas situaciones especiales como la cirugía urgente o la realización de un by pass aorto-coronario requieren esquemas terapéuticos específicos. En todos los casos la valoración entre cirujano, anestesista y endocrinólogo representa la base sobre la que se sustentan los protocolos ter- apéuticos del control de un paciente diabético antes, durante y después del acto quirúrgico. Se debe tener en cuenta que, pese a la realización de protocolos de actuación generales, el tratamiento siempre debe ser individualizado debido a la gran cantidad de factores que pueden influir en el control metabólico., The therapeutic management and metabolic control during surgery has an important significance in order to reduce the course of complications. Maintaining an appropriate hydration state and continuous insulin intravenous administration represents a basic mainstay of surgical management. The possibility of changing insulin doses all through the surgical operation justify the need of frequent blood glucose checking. Some types of surgery, such as emergency surgery or coronary by-pass require specific therapeutic schemes. As a whole the coordination among surgeon, anaesthesiologist and endocrinologist constitutes the basis of the perioperative diabetic management. It must be noticed that this management must be always individualized since multiple factors may influence glycemic control.
- Published
- 2015
27. Position statement: hypoglycemia management in patients with diabetes mellitus. Diabetes Mellitus Working Group of the Spanish Society of Endocrinology and Nutrition
- Author
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Mezquita-Raya P, Reyes-García R, Moreno-Pérez Ó, Muñoz-Torres M, Merino-Torres JF, Gorgojo-Martínez JJ, Jódar-Gimeno E, Escalada San Martín J, Gargallo-Fernández M, Soto-Gonzalez A, González Pérez de Villar N, Becerra Fernández A, Bellido Guerrero D, Botella-Serrano M, Gómez-Peralta F, and López de la Torre Casares M
- Subjects
Diabetes mellitus ,Consensus statement ,Posicionamiento ,Hipoglucemia ,Hypoglycemia - Abstract
OBJECTIVE: To provide practical recommendations for evaluation and management of hypoglycemia in patients with diabetes mellitus. PARTICIPANTS: Members of the Diabetes Mellitus Working Group of the Spanish Society of Endocrinology and Nutrition. METHODS: Recommendations were formulated according to the Grading of Recommendations, Assessment, Development, and Evaluation system to describe both the strength of recommendations and the quality of evidence. A systematic search was made in MEDLINE (PubMed). Papers in English and Spanish with publication date before 15 February 2013 were included. For recommendations about drugs only those approved by the European Medicines Agency were included. After formulation of recommendations, they were discussed by the Working Group. CONCLUSIONS: The document provides evidence-based practical recommendations for evaluation and management of hypoglycemia in patients with diabetes mellitus.
- Published
- 2013
28. Diabetes y cirugía II: Principios generales de tratamiento
- Author
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Santos, E. (E.), Gómez-Peralta, F. (F.), and Salvador, J. (Javier)
- Subjects
Hyperglucemia ,Diabetes ,Insulin resistance ,Insulinorresistencia ,Estrés quirúrgico ,Surgical stress ,Cirugía ,Insulina ,Insulin ,Surgery ,Ciencias de la Salud [Materias Investigacion] ,Insulinodeficiencia ,Hiperglucemia ,Insulin deficiency - Abstract
El manejo terapéutico y de control metabólico del paciente diabético durante el acto quirúrgico posee una trascendencia esencial para reducir la posibilidad de desarrollo de complica- ciones. El mantenimiento de un adecuado estado de hidratación y la administración continua de insulina por vía intravenosa constituyen uno de los pilares básicos del tratamiento intraoperatorio. La posibilidad de variar las dosis de insulina a lo largo de la intervención justifica la necesidad de realizar controles frecuentes de glucemia. Algunas situaciones especiales como la cirugía urgente o la realización de un by pass aorto-coronario requieren esquemas terapéuticos específicos. En todos los casos la valoración entre cirujano, anestesista y endocrinólogo representa la base sobre la que se sustentan los protocolos ter- apéuticos del control de un paciente diabético antes, durante y después del acto quirúrgico. Se debe tener en cuenta que, pese a la realización de protocolos de actuación generales, el tratamiento siempre debe ser individualizado debido a la gran cantidad de factores que pueden influir en el control metabólico. The therapeutic management and metabolic control during surgery has an important significance in order to reduce the course of complications. Maintaining an appropriate hydration state and continuous insulin intravenous administration represents a basic mainstay of surgical management. The possibility of changing insulin doses all through the surgical operation justify the need of frequent blood glucose checking. Some types of surgery, such as emergency surgery or coronary by-pass require specific therapeutic schemes. As a whole the coordination among surgeon, anaesthesiologist and endocrinologist constitutes the basis of the perioperative diabetic management. It must be noticed that this management must be always individualized since multiple factors may influence glycemic control.
- Published
- 2002
29. Diagnóstico diferencial de la hiperandrogenemia mediante inhibición hipofiso-ovárica y estimulación hipofiso-adrenal
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Salvador, J. (Javier), Sopena, M. (Marcos), Esparza, M.L. (M. L.), Alvarez, R. (Rosa), Diez-Goñi, N. (Nieves), Gómez-Peralta, F. (F.), Calleja, A. (Amparo), and Moncada, E. (Emilio)
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Hipofiso-adrenal ,Hiperandrogenemia ,Hipofiso-ovárica ,Diagnóstico diferencial - Published
- 1999
30. Profile of semaglutide in the management of type 2 diabetes: design, development, and place in therapy
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Gomez-Peralta F and Abreu C
- Subjects
semaglutide ,Type 2 Diabetes ,pharmacological treatment ,safety ,clinical practice. ,Therapeutics. Pharmacology ,RM1-950 - Abstract
Fernando Gomez-Peralta, Cristina Abreu Endocrinology and Nutrition Unit, Hospital General de Segovia, Segovia, Spain Abstract: Type 2 diabetes mellitus (T2DM) has become one of the leading causes of morbidity and mortality in developed countries. Low efficacy, weight gain, and hypoglycemia are the main pitfalls of previous treatments for T2DM. New therapies have been designed with the aim of improving the results in efficacy and quality of life. Glucagon-like peptide 1 (GLP-1) receptor agonists (GLP-1 RA) increase glucose-dependent insulin secretion, decrease gastric emptying, and reduce postprandial glucagon secretion. The last GLP-1 RA approved by the US Food and Drug Administration and European Medicines Agency was semaglutide. This review describes its pharmacology, core clinical data coming from the randomized controlled trials included in the development program, proven cardiovascular benefits, safety issues, and precautions for the use of semaglutide in special populations. Additionally, an overview of the positioning of semaglutide in T2DM therapy and practical issues regarding semaglutide initiation are offered. Keywords: semaglutide, type 2 diabetes, pharmacological treatment, safety, clinical practice
- Published
- 2019
31. Indicaciones y contraindicaciones de la nutrición enteral y parenteral
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Santos Mazo, E., primary, Gómez Peralta, F., additional, Lacasa Arregui, C., additional, and Silva Froján, C., additional
- Published
- 2004
- Full Text
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32. Protocolo diagnóstico de la sospecha de astenia de origen endocrino
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Gómez Peralta, F., primary, Santos Mazo, E., additional, Galofré Ferrater, J.C., additional, and Salvador Rodríguez, J., additional
- Published
- 2004
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33. Paciente varón de 49 años con obesidad y astenia
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Santos Palacios, S., primary, Santos Mazo, E., additional, Gómez Peralta, F., additional, and Salvador Rodríguez, J., additional
- Published
- 2004
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34. Desnutrición. Hipovitaminosis
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Silva Froján, C., primary, Payeras Mas, F., additional, and Gómez Peralta, F., additional
- Published
- 2004
- Full Text
- View/download PDF
35. 40(th) EASD Annual Meeting of the European Association for the Study of Diabetes : Munich, Germany, 5-9 September 2004
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S. Artigas, A V Dreval, Mark I. McCarthy, C Watson, Peter H. Bennett, M Quint, Y Ikeda, E Alpert, F Schiele, H Sekihara, Erik Gylfe, P Lowe, J Kuhlmann, Alain Golay, V Longo, Shahidul Alam Khan Akm., L G Mantovani, M Zawodniak-Szalapska, G Winkler, T Harrity, L Virág, U Johne, Kuo S-W., Linda C Tapsell, J Rodriguez, Michel Komajda, K Kankova, Carole A. Cull, M Sporna, E Estilles, U Ribel, M C Spruce, E Buzzigoli, T Prazak, J K McLaughlin, M K Lingohr, M Lim, F Calara, A Siebenhofer, G Meregalli, Roberto Anichini, A D Baron, R Kurashvili, P C Butler, G I Fantus, T. E. De Gooyer, Park Y-M., R. Walther, S Heinrich, Agnieszka Zawiejska, S Mukherjee, Nikolaos Papanas, G Wong, Ian D. Caterson, David M. Maahs, Shuichi Kaneko, Alexandra E. Butler, Francisco Javier Ampudia-Blasco, O N Kong, Attali J-R., C A Hedman, K Oshinyemi, Nicolle Müller, I C Cranston, N Okumus, M V Vlaiculescu, Balasubramanian Ravikumar, W W Cheatham, K Mukasa, K B Biswas, Annunziata Lapolla, Phil McEwan, G Mader, Gilles Chassot, Dragi Anevski, Werner A. Scherbaum, M Donath, C Hesselmann, R A Gandhi, David E. Moller, Ezio Bonifacio, C Garcia, V Ifandi, P Hornnes, Nieuwenhoven Fav., C Puech, S Pérez-Del-Pulgar, Kim S-R., G Hines, C Rubio Terrés, Michael Gaster, N. Hosszufalusi, A Scholze, Andrew A. Young, Stavros Liatis, F Hariri, S Tan, Paul Valensi, Allan E. Karlsen, J Kim, E. Moberg, J Kaiser, L Berman, G Nelson, A Altkrüger, P Kothare, D B Cook, S Doran, G. van Dijk, Shahnaz Shahinfar, Kim C-S., P Stahl, M Manousaki, S Sigrist, S K Lim, M. P. Stern, A Guberti, C Rezzani, J McKenney, Karl Thomaseth, Sofia Carlsson, M Julia, R Brillante, I Rubesova, T Darkow, E Matsumoto, Wendy M. Macfarlane, M Di Martino, G Bardini, Rossella Menghini, D Duhot, E Farcasiu, Annalisa Natalicchio, I Lindner, J Buvat, Christian L. Brand, Harry Dorchy, Iwona Pietrzak, Z T Luo, P Home, M Ekelund, Jesper Gromada, Kristine Færch, F Piarulli, H Kim, R Mentel, Zsuzsanna K. Zsengellér, Dullaart Rpf., Anton Luger, Thomas A. Pearson, V Manicardi, P Rösen, Feng Y-M., R Morganti, Lars Hansen, Demuth H-U., Haruo Kasai, A Shostak, Rudi Steffensen, G Taylor, Markolf Hanefeld, C Santini, E Hamaguchi, Roberto Miccoli, F Storms, M Cooper, Y Lee, Allison E. Aiello, P Smith, T Suehiro, K Treece, M Waluś, Timothy A Welborn, Simone Baltrusch, E Kontela, S Chai, J Crean, H Yokoyama, Johan G. Eriksson, Rafael Hernández Hernández, J Rodríguez-Saldaña, M P Tornero, G Formoso, D. Lovell, E Bingham, A Mylonakis, M Manteghetti, D Fedele, Antonio Martín-Duce, Ralph A. DeFronzo, D Salcedo, Kurt Højlund, Antonio Petrone, Sheu Whh., C Gutierrez, Flavia Pricci, S Kurita, Z G Abbas, M M Benedetti, Philippe A. Halban, Daniel J. Cox, O Ljungkvist, Justine Davies, J Palsgaard, Lars Sjöström, E Bosi, L Janin-Manificat, W. F. Kelly, M. Fernandez, E Colak, O V Mulyarchik, B Kronshage, F Lang, M Erfurth, Takashi Kadowaki, N Jendrike, U Walter, J Wishart, Y. Neye, D Kim, N Furuhashi, M Barsotti, D Florow, L Ke, L Borgquist, N C Jackson, Ffolliott M. Fisher, V Baskar, K Yoshioka, Bryan A. Wolf, G Chabrier, R Skoumal, Livio Luzi, H Kose, I Pharisien, B. Klein, H Winiarska, M C Johnson, L Griffiths, Nonna Kravchun, C Combe, Baptist Gallwitz, J Zdychova, L Skorda, Jorma Ilonen, W Gao, I N Steen, A Terrinoni, P D Ambery, W Kern, C M Kusminski, Cho M-H., Paolo Pozzilli, Louise G. Grunnet, E Schönle, David R Matthews, Robert W. Taylor, Y Cohen, Kim H-S., M P Eccles, N B Tutuncu, D McDowell, Richard M. Bergenstal, K Takamatsu, T Steiner, Jaan Palgi, Valdemar Grill, N Niculescu, G Federici, S Lehto, P. M. McKeigue, M Barone, Michael E. Trautmann, S Smirnov, J Mannion, M Eto, C Rousseau, M Conti, C S Ernest, Antonio Ceriello, D H Schweitzer, Jung E-D., Andreas Festa, Avijit Lahiri, A Shepelkevich, A Murro, A Kollmann, Jonathan R.S. Arch, R Landgraf, Son H-Y., I Engelsberger, E Agardh, S Rodríguez-Mulero, P J Kraml, K Lee, D. F. Du Toit, E Kim, G Fadini, Williams Ajk., Philip Home, M B Antcieferov, C Perlemoine, D Perrea, Song X-L., D Ruggieri, Krister Bokvist, Heidi Sørensen, Bilbao, G Yoshino, J P Taylor, Shen H-M., S M Furier, R Urquhart, J Wohlgelernter, Jianping Weng, T. Baba, Q Hong, C Silva, Castaigne J-P., M Felaco, X X Zhang, M Jaroň, Milla Rosengård-Bärlund, J G Papp, Toshio Miyata, Lervang H-H., Park M-K., I Kinalska, A Long, Oomen Phn., N Kogawa, Ippolita Patrizia Patera, S. Karadeniz, Dinesh Selvarajah, D S Chung, A Wensaas, Richard Imrich, M Recasens, J Ruxer, O Buchea, E Wilpart, S P Stepanenko, Le Ttd., H Ohgawara, Mariaconsuelo Valentini, A Mondok, M Peltonen, Marianne O. Larsen, K Chatzianagnostou, Agneta Ståhle, A L Ferrari, L Bordier, F Maingrette, A Matsuda, G Vukomanovic, Jakob D. Wikstrom, T Yamakita, E Gorostiaga, J Jin, B Gopalan, Heinz Drexel, S Hewitt, Rury R. Holman, C Dieterle, T L Ruchti, N Asatiani, M Sidira, A Iezzi, A J Sommerfield, D Châtenet, M L Olsen, R Bergemann, C Koehler, T L Kuraeva, B Balas, Christian Berne, E Santos-Mazo, G Smith, A Siejka, R Kožnarová, A Mattina, S Sheikh, A Adomeit, M Rasmussen, J. Fagerudd, N Busciantella Ricci, Nuria Vilarrasa, E Hammar, T L Thoms, L Aydın, Ron G. Rosenfeld, A Nikolajuk, R Gos, C L Morgan, H L Yu, D Dheelchand, S Ramrath, N Boudriga, Jerome I. Rotter, C Jahannault, W M Weston, Folke Lindgärde, M Hertlova, D Knight, A Monroy-Mayorga, E Pardini, A Chamson-Reig, B Franke, Janie McCluskey, Joseph Bryan, C Nikolopoulou, Christie M. Ballantyne, Fausto Santeusanio, L Pegoraro, M Lee, A Klimenko, S Jaiveer, K. Pettersson-Fernholm, Michael A. 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Dell'Antonio, G, Maestroni, A, Ruggieri, D, Luzi, L, Piemonti, L, Zerbini, G, Anafaroglu, I, Tutuncu, N, Sultana, M, Siddiqua, N, Iwasaki, T, Nakajima, A, Yoneda, M, Mukasa, K, Tanaka, S, and Sekihara, H
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0303 health sciences ,medicine.medical_specialty ,business.industry ,EASD ,Endocrinology, Diabetes and Metabolism ,Human physiology ,medicine.disease ,03 medical and health sciences ,0302 clinical medicine ,Diabetes mellitus ,Family medicine ,Internal Medicine ,Medicine ,business ,030217 neurology & neurosurgery ,030304 developmental biology - Published
- 2004
36. Impact of Continuous Glucose Monitoring and its Glucometrics in Clinical Practice in Spain and Future Perspectives: A Narrative Review.
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Gómez-Peralta F, Leiva-Gea I, Duque N, Artime E, and Rubio de Santos M
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- Humans, Spain, COVID-19, Hypoglycemia, Child, Adult, SARS-CoV-2, Continuous Glucose Monitoring, Diabetes Mellitus, Type 1 blood, Blood Glucose Self-Monitoring, Blood Glucose analysis
- Abstract
Introduction: Continuous glucose monitoring (CGM) devices allow for 24-h real-time measurement of interstitial glucose levels and have changed the interaction between people with diabetes and their health care providers. The large amount of data generated by CGM can be analyzed and evaluated using a set of standardized parameters, collectively named glucometrics. This review aims to provide a summary of the existing evidence on the use of glucometrics data and its impact on clinical practice based on published studies involving adults and children with type 1 diabetes (T1D) in Spain., Methods: The PubMed and MEDES (Spanish Medical literature) databases were searched covering the years 2018-2022 and including clinical and observational studies, consensus guidelines, and meta-analyses on CGM and glucometrics conducted in Spain., Results: A total of 16 observational studies were found on the use of CGM in Spain, which have shown that cases of severe hypoglycemia in children with T1D were greatly reduced after the introduction of CGM, resulting in a significant reduction in costs. Real-world data from Spain shows that CGM is associated with improved glycemic markers (increased time in range, reduced time below and above range, and glycemic variability), and that there is a relationship between glycemic variability and hypoglycemia. Also, CGM and analysis of glucometrics proved highly useful during the COVID-19 pandemic. New glucometrics, such as the glycemic risk index, or new mathematical approaches to the analysis of CGM-derived glucose data, such as "glucodensities," could help patients to achieve better glycemic control in the future., Conclusion: By using glucometrics in clinical practice, clinicians can better assess glycemic control and a patient's individual response to treatment., (© 2024. The Author(s).)
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- 2024
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37. Diabetes Management Based on the Phenotype and Stage of the Disease: An Expert Proposal from the AGORA Diabetes Collaborative Group.
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Gómez-Peralta F, Pinés-Corrales PJ, Santos E, Cuesta M, González-Albarrán O, Azriel S, and On Behalf The Agora Diabetes Collaborative Group
- Abstract
Diabetes is a complex and rapidly growing disease with heterogeneous clinical presentations. Recent advances in molecular and genetic technologies have led to the identification of various subtypes of diabetes. These advancements offer the potential for a more precise, individualized approach to treatment, known as precision medicine. Recognizing high-risk phenotypes and intervening early and intensively is crucial. A staging system for type 1 diabetes has been proposed and accepted globally. In this article, we will explore the different methods for categorizing and classifying type 2 diabetes (T2D) based on clinical characteristics, progression patterns, risk of complications, and the use of molecular techniques for patient grouping. We, as a team of experts, will also present an easy-to-follow treatment plan and guidance for non-specialists, particularly primary care physicians, that integrates the classification and staging of diabetes. This will help ensure that the most suitable therapy is applied to the different types of T2D at each stage of the disease's progression.
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- 2024
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38. Revolutionizing the management of diabetes: The promise of connected insulin pens and caps.
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Gómez-Peralta F and Abreu C
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- Humans, Hypoglycemic Agents administration & dosage, Hypoglycemic Agents therapeutic use, Diabetes Mellitus drug therapy, Diabetes Mellitus therapy, Insulin Infusion Systems, Diabetes Mellitus, Type 1 drug therapy, Diabetes Mellitus, Type 1 blood, Equipment Design, Insulin administration & dosage, Insulin therapeutic use
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- 2024
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39. Nocturnal Glucose Profile According to Timing of Dinner Rapid Insulin and Basal and Rapid Insulin Type: An Insulclock ® Connected Insulin Cap-Based Real-World Study.
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Gómez-Peralta F, Valledor X, Abreu C, Fernández-Rubio E, Cotovad L, Pujante P, Azriel S, Pérez-González J, Vallejo A, Ruiz-Valdepeñas L, and Corcoy R
- Abstract
Background: A study to assess the glucose levels of people with type 1 diabetes (T1D) overnight, based on the insulin type and timing., Methods: A real-world, retrospective study of T1D, using multiple daily insulin injections. Continuous glucose monitoring and insulin injection data were collected for ten hours after dinner using the Insulclock
® connected cap. Meal events were identified using the ROC detection methodology. The timing of the rapid insulin, second injections, and the type of insulin analogs used, were evaluated., Results: The nocturnal profiles (n = 775, 49 subjects) were analyzed. A higher glucose AUC of over 180 mg/dL was observed in subjects with delayed injections (number; %; mg/dL × h): -45-15 min (n = 136; 17.5%, 175.9 ± 271.0); -15-0 min (n = 231; 29.8%, 164.0 ± 2 37.1); 0 + 45 min (n = 408; 52.6%, 203.6 ± 260.9), ( p = 0.049). The use of ultrarapid insulin (FiAsp® ) (URI) vs. rapid insulin (RI) analogs was associated with less hypoglycemia events (7.1 vs. 13.6%; p = 0.005) and TBR70 (1.7 ± 6.9 vs. 4.6 ± 13.9%; p = 0.003). Users of glargine U300 vs. degludec had a higher TIR (70.7 vs. 58.5%) (adjusted R-squared: 0.22, p < 0.001). The use of a correction injection (n = 144, 18.6%) was associated with a higher number of hypoglycemia events (18.1 vs. 9.5%; p = 0.003), TBR70 (5.5 ± 14.2 vs. 3.0 ± 11.1%; p = 0.003), a glucose AUC of over 180 mg/dL (226.1 ± 257.8 vs. 178.0 ± 255.3 mg/dL × h; p = 0.001), and a lower TIR (56.0 ± 27.4 vs. 62.7 ± 29.6 mg/dL × h; p = 0.004)., Conclusion: The dinner rapid insulin timing, insulin type, and the use of correction injections affect the nocturnal glucose profile in T1D.- Published
- 2024
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40. Preventing alpelisib-related hyperglycaemia in HR+/HER2-/ PIK3CA -mutated advanced breast cancer using metformin (METALLICA): a multicentre, open-label, single-arm, phase 2 trial.
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Llombart-Cussac A, Pérez-Garcia JM, Ruiz Borrego M, Tolosa P, Blanch S, Fernández-Ortega A, Urruticoechea A, Blancas I, Saura C, Rojas B, Bermejo B, Ponce Lorenzo J, Gion M, Cortez-Castedo P, Llabres E, Galve E, Cueva JF, López A, Alonso-Romero JL, González-Santiago S, Martínez de Dueñas E, Ciruelos E, Martrat G, Gener P, Alcalá-López D, Sampayo-Cordero M, Gómez-Peralta F, and Cortés J
- Abstract
Background: Hyperglycaemia is an early and frequent adverse event during alpelisib treatment. METALLICA aimed to evaluate prophylactic metformin to prevent or reduce hyperglycaemia occurrence in patients with HR+/HER2-/ PIK3CA -mutated advanced breast cancer (ABC)., Methods: Between August 13th, 2020 and March 23rd, 2022, this 2-cohort, phase 2, multicentre, single-arm trial (NCT04300790) enrolled patients with HR+/HER2-/PIK3CA-mutated ABC: cohort A, normal glycaemia (fasting plasma glucose <100 mg/dL [<5.6 mmol/L] and HbA1c <5.7%), and cohort B, prediabetes (fasting plasma glucose 100-140 mg/dL [5.6-7.8 mmol/L] and/or haemoglobin A1C [HbA1c] 5.7-6.4%). Participants were at least 18 years old, with Eastern Cooperative Oncology Group performance status of 0-1, and up to two prior lines of endocrine therapy (ET) for ABC. Alpelisib plus ET were administered in 28-day cycles after initiation of prophylactic metformin plus ET. Primary endpoint was the incidence of grade 3-4 hyperglycaemia over the first 8 weeks. Secondary endpoints included safety, progression-free survival (PFS), objective response rate (ORR), and clinical benefit rate (CBR). The primary objective for cohort A and B is met with ≤7 (14.6%) and ≤4 (20%) patients with grade 3-4 hyperglycaemia over the first 8 weeks, respectively., Findings: 233 patients were screened, and 68 (20.2%) patients were enrolled in cohorts A (n = 48) and B (n = 20). Median follow-up was 7.8 months (IQR 1.4-19.6). Over the first 8 weeks, one (2.1%) of 48 patients in cohort A (95% CI: 0.5-11.1; P < 0.0001), and three (15.0%) of 20 patients in cohort B (95% CI: 5.6-37.8; P = 0.016) had grade 3-4 hyperglycaemia. Serious treatment-related adverse events occurred in seven patients (10.3%). The most common were rash (two [2.9%]), vomiting (two [2.9%]), and diarrhoea (two [2.9%]). Discontinuation of alpelisib caused by AEs was reported in nine patients (13.2%), none caused by hyperglycaemia. At data cutoff (15 June, 2022), no treatment-related deaths were observed. In the full analysis set, median PFS was 7.3 months (95% CI: 5.9-not reached), ORR was 20.6% (95% CI: 11.7-32.1%), and CBR was 52.9% (95% CI: 40.4-65.2)., Interpretation: In HR+/HER2-/ PIK3CA -mutated ABC, prophylactic metformin before alpelisib plus endocrine treatment has low incidence and severity of alpelicib-induced hyperglycaemia., Funding: Novartis Pharmaceuticals., Competing Interests: ALC reports research support from Roche, Agendia, Lilly, Pfizer, Novartis, Merck Sharp & Dohme, Gilead, and Daichii-Sanyo; a consulting or advisory role with Lilly, Roche, Pfizer, and Novartis. Speakers’ bureaus for Lilly, AstraZeneca, Merck Sharp & Dohme; travel support from Roche, Pfizer, AstraZeneca; and stock or other ownership in MEDSIR and Initia-Research. JMPG reports a consulting or advisory role with Lilly, Roche, Eisai, Daichii Sankyo, AstraZeneca, Seattle Genetics; and employment at MEDSIR. MRB reports research support and participating in an advisory board of Novartis. PT reports a consulting or advisory role with AstraZeneca, Daiichi-Sankyo, Novartis and Seagen. Speakers’ bureaus for Pfizer, Novartis, Lilly, AstraZeneca, Daiichi-Sankyo and Seagen. IB reports grants and research support to the Institution: AstraZeneca, Lilly, Pfizer and Roche; honoraria and advisor colaboration: AstraZeneca, Roche, Novartis, Eisai, Celgene, Pfizer, Lilly, Pierre-Fabre, Bristol-Myers Squibb, Daiichi Sankyo, Grünenthal, Seagen and Veracyte and support for attending meetings and/or travel: AstraZeneca, Roche, Novartis, Pfizer, Lilly, Pierre-Fabre, Bristol-Myers Squibb and Daiichi Sankyo. BR reports travel support from Roche and Lilly. AFO reports travel support from Novartis. CS reports research support, consulting or advisory role from Genentech, AstraZeneca, Aragon Pharmaceuticals, Bayer Pharma, Byondis, Boehringer Ingelheim, Bristol-Myers Squibb, Cytomx Therapeutics, Daiichi Sankyo, F. Hoffmann-La Roche, Eisai, Genomic Health, GlaxoSmithKline, Innoup Farma, Eli Lilly, Macrogenics, Menarini Ricerche, Merck Sharp & Dohme, Merus, Millennium Pharmaceuticals, Novartis, Pfizer, Pierre Fabre, PintPharma, Puma Biotechnology, Sanofi, Seattle Genetics, Zymeworks. JPL reports honoraria from Seagen, Novartis, Pfizer, AstraZeneca/Daiichi Sankyo, Eli Lilly, Roche; and a consulting or advisory role with Seagen, Novartis, AstraZeneca/Daiichi Sankyo, Roche. EL reports honoraria from Ipsen, MSD, Pfizer, AstraZeneca/Daiichi Sankyo and Roche. EG reports honoraria from Roche/Genentech, Pfizer, Novartis, AstraZeneca, Seagen; a consulting or advisory role with AstraZeneca, Seagen, PharmaMar, Gilead Sciences; and speakers’ bureaus for Pfizer, Novartis, Roche. SGS reports honoraria for speaking from Novartis and GSK; Advisory role from Lilly, Seagen and Astra Zeneca; and travel expenses from Clovis and Pfizer outside the submitted work. EC reports consultancy and speakers’ bureaus for Novartis, Pfizer, Roche, Lilly, Celgene; and personal fees from Novartis, Pfizer, Roche, Lilly, Celgene, during the conduct of the study. JFC reports honoraria from Roche, AstraZeneca, Teva, Celgene, Pfizer, GSK, Novartis; and a consulting or advisory role with Roche, AstraZeneca, Pfizer, GSK, Novartis. MSC reports advisory Board of MEDSIR, Optimapharm; Speaker's Bureau in MEDSIR, Optimapharm; and Funding from MEDSIR, Optimapharm, FGP has taken part in advisory panels for Sanofi and Novo Nordisk; has received research support from Sanofi, Novo Nordisk, Boehringer Ingelheim Pharmaceuticals and Lilly; and has acted as a speaker for Sanofi, Novo Nordisk, Boehringer Ingelheim Pharmaceuticals, AstraZeneca Pharmaceuticals LP, Bristol-Myers Squibb Co. and Lilly. JC reports research support from ARIAD, Astrazeneca, Baxalta GMBH/Servier Affaires, Bayer, Eisai, Guardanth health, Merck Sharp & Dohme, Pfizer, Puma, Queen Mary University of London, Roche, Piqur; honoraria from Novartis, Eisai, Celgene, Pfizer, Roche, Samsung, Eli Lilly, Merck Sharp & Dohme Daiichi Sankyo; a consulting or advisory role with Celgene, Cellestia Biotech, AstraZeneca, Roche, Seattle Genetics, Daiichi Sankyo, ERYTECH Pharma, Polyphor, Athenex, Lilly, SERVIER, Merck Sharp & Dohme, GlaxoSmithKline, Leuko, Clovis Oncology, Bioasis, Boehringer Ingelheim, Ellipses Pharma, HiberCell, Bioinven, GEMoaB, Gilead Sciences, Menarini, Zymeworks, Reveal Genomics; stock or other ownership in Leuko, MEDSIR, Nektar; and travel support from Roche, Pfizer, Eisai, Novartis, Daiichi Sankyo. AU, EMD, SB, BB, MGC, PCC, AL, JLAR report no competing interests. JMPG, GM, PG, DAL, and MSC are employed by MEDSIR., (© 2024 Published by Elsevier Ltd.)
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- 2024
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41. Metabolic and Clinical Outcomes in Type 1 Diabetes in the COVID-19 Pre- and Post-Vaccination Periods in Spain: The COVID-SED1 Study.
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Gómez-Peralta F, Menéndez E, Conde S, Abellán-Galiana P, Brito M, Beléndez M, and Pérez A
- Abstract
Aims: To evaluate the metabolic and clinical outcomes in the Spanish type 1 diabetes mellitus (T1D) population before and after COVID-19 vaccination. Methods: A retrospective observational study was carried out in Spanish public hospitals previously enrolled in the SED1 study. Adults and children with T1D were included and their clinical electronic records were reviewed. Clinical, laboratory, and glucometric parameters from continuous glucose monitoring (CGM) data corresponding to the periods before and after administering the first COVID-19 vaccination were analyzed. Results: A total of 26 centers and 228 patients participated in this new phase of the SED1 study and 187 were finally evaluable (mean age 37.5 ± 15.6 years, 56.7% women). Overall, 94.6% of the sample was vaccinated, and this percentage increased with higher levels of education ( p -value = 0.027). In the pre- and post-vaccination periods, respectively, the number of patients with acute hyperglycemic decompensation was 6/161 (3.7%) and 7/161 (4.3%) ( p = 1) and with acute hypoglycemic decompensation was 6/161 (3.7%) and 6/161 (3.7%) ( p = 1). The HbA1c level was lower in the post-vaccination period(mean ± SD, mg/dL): pre-vaccination 7.4 ± 0.9; post-vaccination 7.2 ± 1.0, (-0.19; p -value = 0.0006). A total of 31.9% of patients (95% CI: 24.7-39.7) in the pre-vaccination period and 45.0% (IC95%: 37.1-53.1) in the post-vaccine period had HbA1c < 7% ( p -value < 0.001). Glucometrics from CGM data also showed numerical improvements post-vaccination. Conclusions: The COVID-19 vaccination was highly accepted in the Spanish T1D population, with hesitancy about the COVID-19 vaccine being higher in those with lower educational levels. A mildly better glycemic control was observed in the post-vaccination period.
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- 2024
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42. Ultrarapid Insulin Use Can Reduce Postprandial Hyperglycemia and Late Hypoglycemia, Even in Delayed Insulin Injections: A Connected Insulin Cap-Based Real-World Study.
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Gómez-Peralta F, Valledor X, López-Picado A, Abreu C, Fernández-Rubio E, Cotovad L, Pujante P, García-Fernández E, Azriel S, Corcoy R, Pérez-González J, and Ruiz-Valdepeñas L
- Subjects
- Humans, Insulin therapeutic use, Hypoglycemic Agents therapeutic use, Blood Glucose Self-Monitoring methods, Retrospective Studies, Blood Glucose, Insulin, Regular, Human, Postprandial Period, Cross-Over Studies, Diabetes Mellitus, Type 1 drug therapy, Hypoglycemia chemically induced, Hypoglycemia prevention & control, Hyperglycemia prevention & control
- Abstract
Objectives: Reaching optimal postprandial glucose dynamics is a daily challenge for people with type 1 diabetes (T1D). This study aimed to analyze the postprandial hyperglycemic excursion (PHEs) and late postprandial hypoglycemia (LPH) risk according to prandial insulin time and type. Research Design and Methods: Real-world, retrospective study in T1D using multiple daily injections (MDI) analyzing 5 h of paired continuous glucose monitoring and insulin injections data collected from the connected cap Insulclock
® . Meal events were identified using the rate of change detection methodology. Postprandial glucometrics and LPH (glucose <70 mg/dL 2-5 h after a meal) were evaluated according to insulin injection time and rapid (RI) or ultrarapid analog, Fiasp® (URI), use. Results: Meal glycemic excursions ( n = 2488), RI: 1211, 48.7%; UR: 1277, 51.3%, in 82 people were analyzed according to injection time around the PHE: -45 to -15 min; -15 to 0 min; and 0 to +45 min. In 63% of the meals, insulin was injected after the PHE started. Lower PHE was observed with URI versus RI (glucose peak-baseline; mg/dL; mean ± standard deviation): 106.7 ± 35.2 versus 111.2 ± 40.3 ( P = 0.003), particularly in 0/+45 injections: 111.6 ± 40.2 versus 118.1 ± 43.3; ( P = 0.002). One third (29.1%) of participants added a second (correction) injection. The use of URI and avoiding a second injection were independently associated with less LPH risk, even in delayed injections (0/+45), (-36%, odds ratio [OR] 0.641; confidence interval [CI]: 0.462-0.909; P = 0.012) and -56% (OR 0.641; CI: 0.462-0.909 P = 0.038), respectively. Conclusions: URI analog use as prandial insulin reduces postprandial hyper- and hypoglycemia, even in delayed injections.- Published
- 2024
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43. GLP-1 receptor agonists and SGLT2 inhibitors: The need to shed light on their safety risks real dimension and possible mechanisms.
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Gómez-Peralta F, Abreu C, and Rizzo M
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- Humans, Glucagon-Like Peptide-1 Receptor agonists, Hypoglycemic Agents adverse effects, Sodium-Glucose Transporter 2 Inhibitors adverse effects, Diabetes Mellitus, Type 2 complications, Diabetes Mellitus, Type 2 drug therapy, Dipeptidyl-Peptidase IV Inhibitors
- Abstract
Competing Interests: Declaration of competing interest This Commentary has been written independently and the authors did not receive any financial or professional help for its preparation. The authors have given lectures, received honoraria and research support, and participated in conferences, advisory boards, and clinical trials sponsored by many pharmaceutical companies. Yet, the industry had no role in this article, which reflects only the opinion of the authors.
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- 2023
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44. Usefulness of circulating EPAC1 as biomarkers of therapeutic response to GLP-1 receptor agonists.
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Hernández C, Gómez-Peralta F, Simó-Servat O, García-Ramírez M, Abreu C, Gómez-Rodríguez S, and Simó R
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- Biomarkers, Cholesterol, LDL, Glucagon-Like Peptide 1 therapeutic use, Glycated Hemoglobin metabolism, Guanine Nucleotide Exchange Factors, Humans, Hypoglycemic Agents therapeutic use, Liraglutide therapeutic use, Pilot Projects, Diabetes Mellitus, Type 2, Glucagon-Like Peptide-1 Receptor agonists
- Abstract
Aims: The response to Glucagon-like peptide-1 receptor agonists (GLP-1RAs) is highly varia-ble among patients. Thus, the identification of predictive biomarkers of therapeutic response to GLP-1 RA could help us to optimize the use of this class of drugs. GLP-1RAs increase exchange proteins directly activated by cAMP (EPAC). The aim of the present study was to assess whether the increase of EPAC1 after GLP-1RAs treatment could be a biomarker of clinical response., Methods: After showing that GLP-1 (10 ng/mL) significantly increased the expression of EPAC1 in human endo-thelial vascular cells (HUVEC), a pilot clinical study was planned. For this purpose 49 patients with type 2 diabetes who started treatment with liraglutide were included. EPAC1 concentration was determined by ELISA before and at one month of liraglutide treatment., Results: We found that serum concentration of EPAC1 increased significantly after treatment with liraglutide. Only in those patients in whom EPAC1 increased (64%), a significant decrease in HbA1c, LDL-C, body mass index (BMI), and waist circumference was shown., Conclusions: This pilot study suggests that the increase of circulating EPAC1 after GLP-1RAs treatment could be a useful biomarker to predict clinical GLP1-RAs response., (© 2022. Springer-Verlag Italia S.r.l., part of Springer Nature.)
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- 2022
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45. Executive summary of the consensus statement of: Clinical recommendations for sport practice in people with diabetes (RECORD Guide). Update 2021. Diabetes Mellitus Area of the Spanish Society of Endocrinology and Nutrition (SEEN).
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Gargallo-Fernández M, Escalada-San Martín J, Chico-Ballesteros A, Lecumberri-Pascual E, Tejera-Pérez C, Fernández-García JC, Rozas-Moreno P, Marco-Martínez A, Gómez-Peralta F, and López-Fernández J
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- Humans, Consensus, Diabetes Mellitus therapy, Endocrinology
- Abstract
Objective: To guide professionals involved in the care of people with diabetes mellitus who practice sport., Participants: Members of the Diabetes Mellitus Working Group of the Spanish Society of Endocrinology and Nutrition., Methods: A group of experts in each area covered by the statement carried out a bibliographic review of the available evidence for each topic, based on which recommendations were subsequently agreed upon within the Diabetes Mellitus Working Group., Conclusions: The statement provides practical recommendations for the management of diabetes mellitus during sports practice., (Copyright © 2021 SEEN and SED. Published by Elsevier España, S.L.U. All rights reserved.)
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- 2022
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46. Clinical Research on Type 2 Diabetes: A Promising and Multifaceted Landscape.
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Gómez-Peralta F and Abreu C
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Type 2 diabetes constitutes an imposing epidemiological, economic, and scientific global challenge [...].
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- 2022
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47. Perceptions about the Management of Patients with DM2 and COVID-19 in the Hospital Care Setting.
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Gómez-Huelgas R and Gómez-Peralta F
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Background: COVID-19 entails a higher rate of complications in subjects with type 2 diabetes mellitus (T2DM). Likewise, COVID-19 infection can cause alterations in glucose metabolism that may lead to worse control. The aim of the study was to analyse the perceptions of a large group of Spanish physicians about the relationship between COVID-19 and T2DM, as well as the management, monitoring, and treatment of both diseases., Methods: A cross-sectional multicenter national project was conducted based on a survey which included opinion, attitude, and behavior (OAB) questions. Physicians specialised in internal medicine or endocrinology, whose usual clinical practices included the management of T2DM, responded to the survey between March and April 2021., Results: A total of 112 participants responded to the survey, from which 64.3% believed that COVID-19 entailed a higher risk of glycaemic decompensation irrespective of the presence of previously known T2DM. Obesity was considered a risk factor for poor control of T2DM by 57.7% and for a worse course of COVID-19 by 61.0%. Treatment intensification in not-on-target patients was considered by 57.1% in the presence of COVID-19 and by 73.2% in the absence of COVID-19. No participants considered the suspension of dipeptidyl peptidase 4 inhibitors (DPP-4i) in ambulatory patients, 85.7% declared that this therapeutic approach in hospitalized patients should be kept, and 88.4% supported the option of maintaining DPP-4i when corticosteroids were prescribed., Conclusion: The physicians involved in the management of T2DM and COVID-19 are aware of the bidirectional relationship between both conditions. However, the monitoring and therapeutic management of patients with T2DM who are infected by SARS-CoV-2 needs improvement through the following of the current recommendations and available evidence.
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- 2022
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48. Patient Preferences for Pharmacological Diabetes Treatment Among People with Diabetes in Spain: A Discrete Choice Experiment.
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Gómez-Peralta F, Mareque M, Muñoz Á, Maderuelo M, and Casado MÁ
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Introduction: The aim of the project was to describe the preferences related to the medication attributes of people with diabetes mellitus (DM) treated in Spain., Methods: The project was carried out in four different phases. In phase A, a Steering Committee defined and selected a total of 18 attributes for treating DM and grouped them into four categories: health outcomes, adverse events, treatment characteristics and cost of treatment. In phase B, a questionnaire according to a discrete choice experiment (DCE) methodology was developed. In phase C, the online DCE survey was sent to members of associations of people with DM from the Spanish Diabetes Federation (FEDE). Finally, in phase D, the results were discussed in a deliberative process., Results: Of the 238 participants who completed the questionnaire (May-September 2020), 231 were included (mean age, 58 years; males, 62%). The DCE results showed that the best-valued category was health outcomes (39.67%), followed by adverse events (26.85%), treatment characteristics (21.70%) and treatment costs (11.77%). Ten of 18 attributes had a significant effect on participants' choice (p < 0.05) and the highest relative importance value: blood pressure reduction (12.82%), hypoglycaemia (12.77%), HbA
1c level reduction (8.54%), cost of the medication (8.13%), needle/tablet size (7.20%), weight change (6.72%), risk of genitourinary infections (6.36%), gastrointestinal problems (5.82%), improved kidney function (5.53%) and administration route (5.41%)., Conclusions: People with DM prefer a treatment that generates benefits in measurable health effects (reducing blood pressure and HbA1c level, while not risking hypoglycaemia) and a convenient route of administration. Considering the preferences of people with DM could generate better clinical results and therapeutic adherence, reducing morbidity, mortality and disease burden., (© 2021. The Author(s).)- Published
- 2022
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49. Clinical characteristics and management of type 1 diabetes in Spain. The SED1 study.
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Gómez-Peralta F, Menéndez E, Conde S, Conget I, and Novials A
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- Adult, Blood Glucose, Blood Glucose Self-Monitoring, Child, Cross-Sectional Studies, Female, Glycated Hemoglobin analysis, Humans, Hypoglycemic Agents therapeutic use, Infusions, Subcutaneous, Insulin Infusion Systems, Male, Spain epidemiology, Diabetes Mellitus, Type 1 drug therapy, Diabetes Mellitus, Type 1 epidemiology
- Abstract
Objectives: To determine the sociodemographic and clinical profile of a representative sample of people with type 1 diabetes mellitus (DM1) in Spain and identify factors associated with glycemic control., Material and Methods: A cross-sectional observational study was carried out in adults and children with DM1 treated in 75 Spanish public hospitals, geographically distributed in order to be representative of the Spanish population. Within each center, the patients were included on a consecutive basis as they visited the clinic. They were interviewed, and their clinical histories were reviewed. A descriptive statistical analysis was made, and factors associated with HbA
1c were analysed using multivariate linear regression analysis., Results: A total of 647 patients were included: 55.3% females, aged 36.6 ± 14.4 years, 97.2% Caucasians, BMI 24.7 ± 4.4 kg/m2 (12.1% ≥ 30 kg/m2 ), and 74.0% had secondary / university education. A total of 20.2% were active smokers. The mean time from the diagnosis of DM1 was 17.9 ± 12.0 years. A total of 48.7% presented comorbidities: 19.3% retinopathy and 16.4% hypothyroidism. As regards treatment for DM1, 76.5% received basal-bolus insulin therapy and 20.7% continuous subcutaneous insulin infusion (CSII); 51.0% of the patients used an insulin/carbohydrate ratio (ICR), with 4.6 ± 1.6 self-monitored capillary blood glucose (SMCBG) measurements a day, and 24.8% used continuous glucose monitoring (CGM). The mean HbA1c value was 7.6 ± 1.1% (30% below 7%). Metabolic control improved (lower HbA1c ) with more daily SMCBG (B = -0.053; p = 0.009), a higher educational level (B = 0.461; P < 0.001), greater number of hypoglycemia episodes (B = -0.253; P = 0.018) and carbohydrate counting (B = -0.190; P = 0.048), and worsened the longer the duration of the disease (B = 0.010; P = 0.010), higher total dose of insulin (B = 0.010; P < 0.0001), poorer adherence to diet (B = 0.650; P < 0.0001) and a family history of DM (B = -0.233; P = 0.007)., Conclusions: The management of patients with DM1 in Spain, as well as the treatment they receive, is similar to that seen in other Western countries. Blood glucose control is associated with educational level, disease duration, and the characteristics of treatment and self-care., (Copyright © 2021 SEEN and SED. Published by Elsevier España, S.L.U. All rights reserved.)- Published
- 2021
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50. Executive summary of the consensus statement of: Clinical recommendations for sport practice in people with diabetes (RECORD Guide). Update 2021. Diabetes Mellitus Area of the Spanish Society of Endocrinology and Nutrition (SEEN).
- Author
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Gargallo-Fernández M, Escalada-San Martín J, Chico-Ballesteros A, Lecumberri-Pascual E, Tejera-Pérez C, Fernández-García JC, Rozas-Moreno P, Marco-Martínez A, Gómez-Peralta F, and López-Fernández J
- Published
- 2021
- Full Text
- View/download PDF
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