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14 results on '"Gómez-Llorente, Yacob"'

1. Structural model of the dimeric Parkinson’s protein LRRK2 reveals a compact architecture involving distant interdomain contacts

Author

Guaitoli, Giambattista, Raimondi, Francesco, Gilsbach, Bernd K., Gómez-Llorente, Yacob, Deyaert, Egon, Renzi, Fabiana, Li, Xianting, Schaffner, Adam, Jagtap, Pravin Kumar Ankush, Boldt, Karsten, von Zweydorf, Felix, Gotthardt, Katja, Lorimer, Donald D., Yue, Zhenyu, Burgin, Alex, Janjic, Nebojsa, Sattler, Michael, Versées, Wim, Ueffing, Marius, Ubarretxena-Belandia, Iban, Kortholt, Arjan, and Gloeckner, Christian Johannes

Published
2016

6. Structural basis for active single and double ring complexes in human mitochondrial Hsp60-Hsp10 chaperonin

Author

United States-Israel Binational Science Foundation, Council for Higher Education (Israel), Fundación Biofísica Bizkaia, Eusko Jaurlaritza, Azem, Abdussalam [0000-0002-2288-2986], Hirsch, Joel A. [0000-0001-7544-8668], Ubarretxena, Iban [0000-0003-4082-4349], Gómez-Llorente, Yacob, Jebara, Fady, Patra, Malay, Malik, Radhika, Nisemblat, Shahar, Chomsky-Hecht, Orna, Parnas, Avital, Azem, Abdussalam, Hirsch, Joel A., Ubarretxena, Iban, United States-Israel Binational Science Foundation, Council for Higher Education (Israel), Fundación Biofísica Bizkaia, Eusko Jaurlaritza, Azem, Abdussalam [0000-0002-2288-2986], Hirsch, Joel A. [0000-0001-7544-8668], Ubarretxena, Iban [0000-0003-4082-4349], Gómez-Llorente, Yacob, Jebara, Fady, Patra, Malay, Malik, Radhika, Nisemblat, Shahar, Chomsky-Hecht, Orna, Parnas, Avital, Azem, Abdussalam, Hirsch, Joel A., and Ubarretxena, Iban

Abstract

mHsp60-mHsp10 assists the folding of mitochondrial matrix proteins without the negative ATP binding inter-ring cooperativity of GroEL-GroES. Here we report the crystal structure of an ATP (ADP:BeF3-bound) ground-state mimic double-ring mHsp6014-(mHsp107)2 football complex, and the cryo-EM structures of the ADP-bound successor mHsp6014-(mHsp107)2 complex, and a single-ring mHsp607-mHsp107 half-football. The structures explain the nucleotide dependence of mHsp60 ring formation, and reveal an inter-ring nucleotide symmetry consistent with the absence of negative cooperativity. In the ground-state a two-fold symmetric H-bond and a salt bridge stitch the double-rings together, whereas only the H-bond remains as the equatorial gap increases in an ADP football poised to split into half-footballs. Refolding assays demonstrate obligate single- and double-ring mHsp60 variants are active, and complementation analysis in bacteria shows the single-ring variant is as efficient as wild-type mHsp60. Our work provides a structural basis for active single- and double-ring complexes coexisting in the mHsp60-mHsp10 chaperonin reaction cycle.

Published
2020

8. Estudios estructurales en la proteína helicasa MCM de 'Methanobacterium thermoautotrophicum'

Author

Gómez Llorente, Yacob, San Martín Pastrana, Carmen, Carazo García, José María, and Universidad Autónoma de Madrid. Departamento de Biología Molecular

Subjects
Proteínas - Estructura - Tesis Doctorales
Abstract

Tesis Doctoral inédita leída en la Universidad Autónoma de Madrid, Facultad de Ciencias, Departamento de Biología Molecular. Fecha de lectura: 23-10-2007

Published
2007

10. G protein Gating of a Kir3.1-Prokaryotic Kir Channel Chimera Functionally Reconstituted in Planar Lipid Bilayers

Author

Leal-Pinto, Edgar, primary, Gómez-Llorente, Yacob, additional, Sundaram, Shobana, additional, Tang, Qiong-Yao, additional, Ivanova-Nikolova, Tatyana, additional, Mahajan, Rahul, additional, Baki, Lia, additional, Zhang, Zhe, additional, Chavez, Jose, additional, Ubarretxena-Belandia, Iban, additional, and Logothetis, Diomedes E., additional

Published
2011
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