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In Costa Rica, a land tax valuation model provided by the Technical Standardization Body (ONT) of the Ministry of Finance is used. This model considers homogeneous areas that include properties with similar characteristics and review factors that have not been recently updated. The objective of this article is to determine the effect of the distance to the train station and mobile coverage on the value of land in Oreamuno, Costa Rica, as a proposal to be included in the mass valuation model of the ONT. A multiple regression econometric model was used to establish the functional relationship between the value of the property and its characteristics, through the Ordinary Least Squares (OLS) method, using 10 variables applied to 200 references initially. The results allow demonstrating that other variables such as “Distance to the train station” and “Mobile coverage” are representative for determining the value of properties, in addition to those commonly used by the ONT model. The research allows concluding that the land valuation models should be updated periodically and should include variables related to improvements in technology and access roads, since these increase the market value of properties and improve the social development of localities in study.

Black broom (Sarothamnus scoparius) is a bush that grows abundantly in the region of Extremadura. The potential use of this lignocellulosic material as raw material for the preparation of activated carbon by physical activation is investigated. The activated carbons are characterised by means of chemical analysis, N2 adsorption at 77 K, mercury porosimetry and helium and mercury densities. It has been observed that the activation in CO2 atmosphere leads to better textural properties than those obtained when air was used as activating agent. The effects of the activation procedure on the textural properties of the samples are favoured with the increase in the activation temperature.La retama negra (Sarothamnus scoparius) es un arbusto que crece en forma abundante en la región extremeña. En el presente estudio se investiga su posible utilización como material de partida en la preparación de carbón activado. Ésta se lleva a cabo por el método de activación física. Los carbones son caracterizados mediante análisis químico, adsorción de N2 a 77 K, porosimetría de mercurio y medida de densidades por desplazamiento de helio y de mercurio. Se ha constatado que activando en CO2 se preparan carbones activados que poseen unas mejores propiedades texturales que los obtenidos utilizando aire. Los efectos de la activación sobre las propiedades texturales de los carbones se favorecen con la subida de la temperatura de activación.

El pasado 27 de octubre falleció Clemencia, su muerte prematura para lo que hubiésemos deseado; reiteró nuevamente cómo cada ser humano tiene su propio camino, ya corto, ya extenso y durante el debe construir su historia y su legado para la sociedad. Obtuvo su título de licenciada en enfermería en 1969 en la Pontificia Universidad Javeriana y desde entonces trasegó con el ejercicio de la enfermería; práctica que fue asumida por Clemencia con responsabilidad, compromiso, entereza, calidad y visión futurista.

La conmemoración de los 75 años de creación del primer programa de enfermería vinculado con la Universidad Nacional de Colombia se convierte en momento ideal para la reflexión en torno a su discurrir histórico, a los compromisos actuales y al futuro deseable para nuestra facultad. Dado que en esta ponencia es imposible presentar de manera profunda y detallada todas las etapas de desarrollo; se desarrollará un resumen muy general de algunos apartes de la historia; situación que le imprime a esta primera parte del trabajo un carácter de generalización y por ello se apreciará la ausencia de algunos elementos que en cada momento han sido significativos. En la segunda parte del trabajo se presentará, también de manera general, el plan de desarrollo que se encuentra en proceso de construcción en la facultad, el que se ha de constituir en el documento orientador de nuestro trabajo para los próximos años.

Hoy en día la enfermería tiene el reto de seguir construyéndose en el ámbito profesional y disciplinar, dejando atrás el sello tradicional de lo femenino para continuar su proceso de desarrollo y cambio en términos de su propia esencia; el cuidado de la salud y de la vida del ser humano.

Son múltiples los factores que se han vinculado con el desarrollo de la profesión de enfermería, tanto en su desempeño como en la formación académica, en cada momento histórico en particular. La estructura económico- política, las organizaciones de poder, los conflictos nacionales e internacionales, los papeles del género femenino y de clase social, los avances científicos, tecnológicos y técnicos, el sistema educativo y sanitario, las diferentes categorías socio-profesionales y las propias metas de desarrollo de la profesión han sido determinantes en la evolución que hasta el momento actual ha logrado nuestra profesión.

La reseña de la carrera se presenta en dos momentos históricos. El primero, desde su vinculaci6n a la Universidad como programa anexo a la Facultad de Medicina y el segundo, a partir de la Facultad de Enfermería, hasta la fecha.

Abstract Background Elucidating the activation pattern of molecular pathways across a given tumour type is a key challenge necessary for understanding the heterogeneity in clinical response and for developing novel more effective therapies. Gene expression signatures of molecular pathway activation derived from perturbation experiments in model systems as well as structural models of molecular interactions ("model signatures") constitute an important resource for estimating corresponding activation levels in tumours. However, relatively few strategies for estimating pathway activity from such model signatures exist and only few studies have used activation patterns of pathways to refine molecular classifications of cancer. Methods Here we propose a novel network-based method for estimating pathway activation in tumours from model signatures. We find that although the pathway networks inferred from cancer expression data are highly consistent with the prior information contained in the model signatures, that they also exhibit a highly modular structure and that estimation of pathway activity is dependent on this modular structure. We apply our methodology to a panel of 438 estrogen receptor negative (ER-) and 785 estrogen receptor positive (ER+) breast cancers to infer activation patterns of important cancer related molecular pathways. Results We show that in ER negative basal and HER2+ breast cancer, gene expression modules reflecting T-cell helper-1 (Th1) and T-cell helper-2 (Th2) mediated immune responses play antagonistic roles as major risk factors for distant metastasis. Using Boolean interaction Cox-regression models to identify non-linear pathway combinations associated with clinical outcome, we show that simultaneous high activation of Th1 and low activation of a TGF-beta pathway module defines a subtype of particularly good prognosis and that this classification provides a better prognostic model than those based on the individual pathways. In ER+ breast cancer, we find that simultaneous high MYC and RAS activity confers significantly worse prognosis than either high MYC or high RAS activity alone. We further validate these novel prognostic classifications in independent sets of 173 ER- and 567 ER+ breast cancers. Conclusion We have proposed a novel method for pathway activity estimation in tumours and have shown that pathway modules antagonize or synergize to delineate novel prognostic subtypes. Specifically, our results suggest that simultaneous modulation of T-helper differentiation and TGF-beta pathways may improve clinical outcome of hormone insensitive breast cancers over treatments that target only one of these pathways.

Background: Predictors of permanent pacemaker implantation (PPMI) after self-expanding transcatheter aortic valve implant (TAVI) were described. Is unknown if PPMI predictors remain in the era of high implants using the cusp overlap (COP)., Methods: Single-center, prospective, consecutive case series of patients undergoing self-expanding TAVI with the COP approach. The status of PPMI and other clinical events were ascertained at 30 days., Results: A total of 261 patients were included (84% with Evolut, n = 219). Implant depth >4 mm was infrequent (13.8%). TAVI depth (OR 1.259; p = 0.005), first or second-degree auriculo-ventricular block (OR 3.406; p = 0.033), right-bundle (OR 15.477; p < 0.0001), and incomplete left-bundle branch block (OR 7.964; p = 0.036) were found to be independent predictors of PPMI. The risk of PPMI with deep implant and no electrical disturbances was 3%, and 0% with high implant and no prior electrical disturbances. Those who received PPMI had no statistically significant increased risk of death, myocardial infarction, stroke, bleeding events, or vascular complications at 30 days, but longer hospital stay (mean difference 1.43 days more, p = 0.003)., Conclusions: Implant depth and prior conduction abnormalities remain the main predictors of PPMI using self-expanding TAVI in the COP era. Patients with high implants and no prior conduction abnormalities may be candidates for early discharge after uneventful self-expanding TAVI, while the rest may need inpatient monitoring regardless of achieving a high implant. The need for PPMI was associated with longer hospital stays., (© 2024 Wiley Periodicals LLC.)

Introduction: Metabolic and bariatric surgery (MBS) has experienced considerable growth, addressing the challenges of obesity and its complications. The lack of a comprehensive bibliometric analysis in Latin America motivates this study, highlighting the need to understand the evolution of research in this area and its impact on clinical decision-making and health policies., Methodology: A cross-sectional bibliometric study was carried out using the Scopus database. A structured search strategy was designed to identify articles related to bariatric surgery with authors affiliated with Latin American countries. Inclusion and exclusion criteria were applied, followed by a descriptive and bibliometric analysis of the scientific production found., Results: A total of 3553 documents published between 1991 and 2024 were included. There was an annual growth of 11%, with an average age of documents of 7.5 years. A concentration was observed in some countries, notably Brazil, Mexico, and Chile. Although scientific output increased, the average number of citations per article showed a downward trend since 2003., Discussion: Despite the growth in scientific production, the quality and relevance of research is questioned, especially given the decrease in the impact received. It highlights the lack of meaningful regional collaboration, which could limit the sharing of knowledge and resources. Questions are raised about gaps in research capacity and the economic and development implications are discussed., Conclusions: This study provides valuable information to strengthen future research in bariatric surgery in Latin America. It highlights the importance of promoting regional and international collaboration and improving research training in countries with less participation. Clinical intervention strategies can benefit from better understanding research trends and adopting evidence-based practices in a more informed manner., (© 2024. The Author(s).)

Over the course of revising the genus Rinorea (Violaceae) from Colombia, field observations and herbarium studies revealed seven new species. Several of the new species described here belong to species complexes that required examination of herbarium material from across the Neotropics. Each of the new species described here have oppositely arranged leaves and belong to Rinoreasect.Pubiflorae, a section restricted to the Neotropics. Two new species are segregated from the R.ovalifolia species complex: Rinoreachiribiquetensis from Chiribiquete National Park in the Colombian Amazon and Rinoreastevensii from the Orinoco River near the border of Colombia and Venezuela. Two new species are segregated from the Rinoreahirsuta species complex: Rinoreagaleanoae-bernalii and Rinoreacogolloi , both from the eastern slopes of the Andean Central Cordillera along the mid-Magdalena River Valley in Colombia. From the widely distributed R.pubiflora species complex, we segregated one new species, Rinoreacallejasii , from southeast Panama and the Chocó in Colombia. In addition to these five new taxa segregated from widely distributed species complexes, we discovered two previously unknown species with affinities to other Neotropical Rinorea . Rinoreaaymardii is described from the Alto Orinoco-Casiquiare Biosphere Reserve in Venezuela and most closely resembles R.melanodonta from Colombia. Rinoreabetancurii is segregated from R.macrocarpa and occurs in the Amazonian Regions of Colombia, Brazil, Peru and Venezuela. In this study, we provide descriptions, illustrations and distribution maps of the new species and make preliminary assessments of the risk of extinction using the IUCN Red List Categories and Criteria. We also furnish an identification key to the species of Rinoreasect.Pubiflorae in Colombia., Competing Interests: The authors have declared that no competing interests exist., (Saúl E. Hoyos-Gómez, Ricardo Callejas Posada, Gregory A. Wahlert.)

Background: Neighbors are an important component of personal social network (PSN) and despite their peripheral role and being considered as familiar strangers, they typically provide instrumental support. For people who is discharged after long-term psychiatric hospitalizations, neighbors would offer other types of social support and play a different role fostering the process of becoming full member of a given community., Aims: To analyze the effects of neighboring on both, those who have had long-term psychiatric hospitalizations and their neighbors., Method: Data was collected between 2020 and 2021, including interviews with formal care staff of three housing support experiences in Argentina, and short testimonies from formerly discharged mental health service users living in the community and their neighbors. We analyzed the data using the Framework Method with a focus on the different aspects of social support and equity and reciprocity theories., Results: Results suggest that emotional support was a frequent function displayed by neighbors toward people with a history of long-term psychiatric hospitalizations, which differs from typical neighboring relationships., Conclusions: Despite reciprocity was observed, users and neighbors displayed an unbalanced helping relationship.

The structural, vibrational, and electronic properties of new inorganic X-phosphide nanotubes ( ch -XPNT), with X = Al, Ga, or In and chirality of (5,5), are investigated. These new NTs display cap-hole ends, with the cap-hole features induced by the nonpassivated ends. Studies are based on density functional theory (DFT) using the M06-2X, PBE, and B3LYP functionals together with the LanL2DZ basis set. All nanostructures have been relaxed by minimizing the total energy, assuming a nonmagnetic nature and a total neutral charge. Note that the cap-hole NTs are terminated by a 10-atom ring, which in turn favors the geometrical ordering and yields stable structures. The (5,5) ch -XPNT are highly electrophilic and nonpolar, in addition to having high solvation energy values. Let us remark that solvation energies are produced by the intermolecular forces that involve the induced dipoles. Structural and vibrational results show that the X-P bonds are single bonds. Finally, results suggest that the inorganic nanotubes are structurally stable with semiconductor features, which means that their functionalization may yield interesting future applications., Competing Interests: The authors declare no competing financial interest., (© 2024 The Authors. Published by American Chemical Society.)

Background: Lockdowns have been one of the government's primary measures to control COVID-19, especially during the initial waves of the pandemic, but there is concern on the impact of lockdowns on people's mental health. Confinement is still today the reality of many people with severe mental illness in many places of the world., Objective: Given that the general population experienced confinement during the COVID-19 pandemic, we sought to explore if that affected perceptions about long-term psychiatric hospitalizations., Methods: About 134 residents from middle-class neighborhoods in urban settings in the Province of Buenos Aires, Argentina, were surveyed. Participants were asked if they felt emotionally affected by the pandemic and lockdown, and about their perceptions of long-term psychiatric hospitalizations. Association between personal emotional impact by the pandemic or lockdown with perceptions about long-term psychiatric hospitalization were analyzed using chi-square test. Qualitative analysis of pandemic and lockdown effects was held., Results: Respondents tended to overlap the emotional effects of the pandemic and the lockdown. Some responses explicitly referred to confinement. No association was observed between emotional impact by the pandemic or lockdown and perceptions about long-term psychiatric hospitalization among the sample. The general population's perceptions of long-term psychiatric hospitalization do not appear to be affected by the first-hand experience of confinement, which suggest persistence of stigma, and the need to reconsider public policies and actions that attempt to impact on it.

Objectives: Prostate cancer (PCa) is the most common adenocarcinoma in men >50 y of age. It has a long latency period, which provides time for preventive strategies like incorporating healthy eating habits. Yerba mate (YM) intake has been associated with numerous health benefits. Since YM is one of the most popular infusions in Argentina, the of this study was to examine the influence of YM on PCa development., Methods: We carried out an in vivo model of PCa through subcutaneous inoculation of transgenic adenocarcinoma of the mouse prostate-C1 cells in C57BL/6 mice. Subsequently, the animals were divided into two groups: mate (25 mg/mL of YM in drinking water, n = 15), and control (only drinking water, n = 15). We also developed an in vitro model to study the direct effects of YM on three human PCa cell lines: lymph node carcinoma of the prostate (LNCaP), PC-3, and DU-145., Results: Our in vivo model showed that YM intake slightly reduced body weight, increased the latency of tumor appearance (P <0.01), and diminished the tumor volume (P <0.05) compared with the control group. In agreement, the expression of proliferating cell nuclear antigen, and nuclear estrogen receptor α were lower in the tumors of the mate animals (P <0.05). In vitro, YM decreased the viability, proliferation, and adhesion of the three tumor cell lines (P < 0.001) and retarded the migration of LNCaP (P <0.05) and DU-145 (P <0.005), without modifying the migration of PC-3 cells., Conclusions: YM showed anticancer effects in vitro and in vivo and were more effective on the androgen-sensitive cell line (LNCaP)., (Copyright © 2022 Elsevier Inc. All rights reserved.)

The topographic gradients of the Tropical Andes may have triggered species divergence by different mechanisms. Topography separates species' geographical ranges and offers climatic heterogeneity, which could potentially foster local adaptation to specific climatic conditions and result in narrowly distributed endemic species. Such a pattern is found in the Andean centered palm genus Aiphanes . To test the extent to which geographic barriers and climatic heterogeneity can explain distribution patterns in Aiphanes , we sampled 34 out of 36 currently recognized species in that genus and sequenced them by Sanger sequencing and/or sequence target capture sequencing. We generated Bayesian, likelihood, and species-tree phylogenies, with which we explored climatic trait evolution from current climatic occupation. We also estimated species distribution models to test the relative roles of geographical and climatic divergence in their evolution. We found that Aiphanes originated in the Miocene in Andean environments and possibly in mid-elevation habitats. Diversification is related to the occupation of the adjacent high and low elevation habitats tracking high annual precipitation and low precipitation seasonality (moist habitats). Different species in different clades repeatedly occupy all the different temperatures offered by the elevation gradient from 0 to 3,000 m in different geographically isolated areas. A pattern of conserved adaptation to moist environments is consistent among the clades. Our results stress the evolutionary roles of niche truncation of wide thermal tolerance by physical range fragmentation, coupled with water-related niche conservatism, to colonize the topographic gradient., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2022 Sanín, Borchsenius, Paris, Carvalho-Madrigal, Gómez Hoyos, Cardona, Arcila Marín, Ospina, Hoyos-Gómez, Manrique and Bernal.)

Introduction: Housing is one of the main supports needed to guarantee community life of people who had long-term psychiatric hospitalizations. In Argentina, housing support experiences have been developed for decades, although their systematization is scarce. The objective of this paper is to describe three housing support experiences developed in the province of Buenos Aires, Argentina, which have continuity over time for more than 20 years., Materials and Methods: Document analysis and interviews with workers from the three experiences were carried out, as part of a broader project on community life and neighborhood relations of people discharged after long-term psychiatric hospitalizations. The material was analyzed qualitatively, using a time dimension and a structure and functioning one which included financing, technical resources, housing devices and support provided., Results: Although the types of support provided are somehow similar between the three experiences, heterogeneity in structure and functioning is observed., Discussion and Conclusions: Despite the fact that the human rights framework proposes the provision of flexible and adequate support according to the needs of people, it is worth reflection on whether the reduced systematization of experiences such as those presented is due to the difficulties of the heterogeneity mentioned, or is due to a scarce evaluation culture that obstacles the learning from those experiences.

Background: The Atlantic Forest is one of the most threatened biomes in the world. Despite that, this biome still includes many areas that are poorly known floristically, including several protected areas, such as the "Floresta Nacional do Rio Preto" ("Flona do Rio Preto"), located in the Brazilian State of Espírito Santo. This study used a published vascular plant species list for this protected area from the "Catálogo de Plantas das Unidades de Conservação do Brasil" as the basis to synthesise the species richness, endemism, conservation and new species occurrences found in the "Flona do Rio Preto"., New Information: The published list of vascular plants was based on field expeditions conducted between 2018 and 2020 and data obtained from herbarium collections available in online databases. Overall, 722 species were documented for the "Flona do Rio Preto", 711 of which are native to Brazil and 349 are endemic to the Atlantic Forest. In addition, 60 species are geographically disjunct between the Atlantic and the Amazon Forests. Most of the documented species are woody and more than 50% of these are trees. Twenty-three species are threatened (CR, EN and VU), while five are Data Deficient (DD). Thirty-two species are new records for the State of Espírito Santo. Our results expand the knowledge of the flora of the Atlantic Forest and provide support for the development of new conservation policies for this protected area., (Anderson Alves-Araújo, Marina M Moreira, Tatiana T Carrijo, Lúcia G Lohmann, Adriana Q Lobão, Alana F Scheidegger, Aline D Firmino, Aline Vieira de Melo Silva, Álvaro Nepomuceno, Amélia C Tuler, André MA Amorim, André LC Moreira, Braz AP Cosenza, Brenno G Sossai, Christian Silva, Claudia R Lopes, Daniele Monteiro, Dayvid R Couto, Duane F Lima, Eduardo C Dalcin, Eliana Ramos, Elton J Lírio, Fatima Salimena, Felipe Alves de Oliveira, Fernanda RM Fraga, Filipe Torres-Leite, Guilherme M Antar, Gustavo H Shimizu, Haroldo C Lima, Herison Medeiros, Jaquelini Luber, Jheniffer A Christ, João Lanna, João Paulo F Zorzanelli, Joelcio Freitas, José FB Pastore, José IM Melo, Juliana Paula-Souza, Juliana RPM Oliveira, Leandro C Pederneiras, Leandro Freitas, Leandro L Giacomin, Leonardo D Meireles, Luis AE Silva, Luiz JS Pinto, Luiz Menini Neto, Marcelo Trovó, Mário L Garbin, Marli P Morim, Michel Ribeiro, Nelson TL Pena, Paulo H Labiak, Pedro H Cardoso, Pedro L Viana, Pedro LR Moraes, Quélita S Moraes, Raquel F Zorzanelli, Renara N Amaral, Renata C Asprino, Renato Goldenberg, Ricardo Magnago, Ricardo S Couto, Sandrine C Dutra, Saúl E Hoyos-Gómez, Tamara AF Vieira, Thiago B Flores, Valquíria F Dutra, Víctor S Miranda, Vitor C Manhães, Rafaela C Forzza.)

Objectives: The aim of the study was to investigate the efficacy of intravenous (IV) smart pumps with drug libraries and dose error reduction system (DERS) to intercept programming errors entailing high risk for patients in an adult intensive care unit (ICU)., Methods: A 2-year retrospective study was conducted in the adult ICU of the Hospital Juárez de México in Mexico City to evaluate the impact of IV smart pump/DERS (Hospira MedNet) technology implementation. We conducted a descriptive analysis of the reports generated by the system's software from April 2014 through May 2016. Our study focused on the upper hard limit alerts and used the systems' variance reports and IV Medication Harm Index methodology to determine the severity of the averted overdoses for medications with the highest number of edits., Results: The system monitored 124,229 infusion programs and averted on 36,942 deviations of the preset safe limits. Upper hard limit alerts accounted for 26.4% of pump reprogramming events. One hundred sixty-six significant administration errors were intercepted and prevented, and IV Medication Harm Index analysis identified 83 of them as highest-risk averted overdoses with insulin accounting for 51.8% of those. The rate of compliance with the safety software during the study period was 69.8%., Conclusions: Our study contributes additional evidence of the impact of IV smart pump/DERS technology. These pumps effectively intercepted severe infusion errors and significantly prevented adverse drug events related to dosing. Our results support the implementation of this technology in ICUs as a minimum safety standard and could help drive an IV infusion safety initiative in Mexico., Competing Interests: The authors disclose no conflict of interest., (Copyright © 2017 Wolters Kluwer Health, Inc. All rights reserved.)

The oral squamous cell carcinoma (OSCC), which has a high morbidity rate, affects patients worldwide. Changes in SPINK7 in precancerous lesions could promote oncogenesis. Our aim was to evaluate SPINK7 as a potential molecular biomarker which predicts OSCC stages, compared to: HER2, TP53, RB1, NFKB and CYP4B1. This study used oral biopsies from three patient groups: dysplasia (n = 33), less invasive (n = 28) and highly invasive OSCC (n = 18). The control group consisted of clinically suspicious cases later to be confirmed as normal mucosa (n = 20). Gene levels of SPINK7, P53, RB, NFKB and CYP4B1 were quantified by qPCR. SPINK7 levels were correlated with a cohort of 330 patients from the TCGA. Also, SPINK7, HER2, TP53, and RB1, were evaluated by immunohistofluorescence. One-way Kruskal-Wallis test and Dunn's post-hoc with a p < 0.05 significance was used to analyze data. In OSCC, the SPINK7 expression had down regulated while P53, RB, NFKB and CYP4B1 had up regulated (p < 0.001). SPINK7 had also diminished in TCGA patients (p = 2.10e-6). In less invasive OSCC, SPINK7 and HER2 proteins had decreased while TP53 and RB1 had increased with respect to the other groups (p < 0.05). The changes of SPINK7 accompanied by HER2, P53 and RB1 can be used to classify the molecular stage of OSCC lesions allowing a diagnosis at molecular and histopathological levels.

Background: The use of smart pump technology has shown to be profitable in the intensive care unit (ICU) because it avoids costs from prevented medication errors and allows for savings on disposables and medications by establishing standardized concentrations and dosing units. Objective : The objective of the study is to evaluate the economic impact of the implementation of smart infusion pumps in the consumption of intravenous (IV) solutions in an ICU. Methods: A retrospective observational study was conducted with a pre-post design. The study occurred in the adult ICU of the Hospital Juárez de México. The pattern of consumption of IV solutions (sodium chloride 9%, Hartmann's solution, dextrose 5% and 10%, sodium chloride 0.9% with dextrose 5%) was analyzed preimplementation and postimplementation of 50 Plum A+™ pumps with Hospira MedNet™ security software. Using the TreeAge Pro 2016 software, deterministic and probabilistic analyses were carried out (10 000 Monte Carlo simulations) to confirm the robustness of the annual consumption comparison and the associated expenses before and after implementing smart technology. Results : The implementation of the smart pumps reduced the annual consumption of IV solutions to 8994 units (18%) and 3649 liters (22.3%). In the first year, MXN$55 850.97 were saved. From an institutional perspective and with a probability of 0.63, the use of MedNet™ technology proved to be a lower cost alternative (17.1% saved) with respect to the conventional infusion systems. Conclusion : The implementation of smart infusion pumps allows savings, specifically for the IV solutions used in ICU., Competing Interests: Declaration of Conflicting Interests: The author(s) declared the following potential conflicts of interest with respect to the research, authorship, and/or publication of this article: Erika Palacios-Rosas, Isaac F. Soria-Cedillo, Fabiola Puértolas-Balint, Rebecca Ibarra-Pérez, Sergio E. Zamora-Gómez, Elizabeth Lozano-Cruz, Marcos A. Amezcua-Gutiérrez, and Lucila I. Castro-Pastrana have no conflicts of interest that are directly relevant to the content of this article.

We studied the epidemiologic triad-related factors influencing human papilloma virus (HPV) persistence in Mexican women with systemic lupus erythematosus (SLE). Patients aged ≥18 years with SLE (American College of Rheumatology criteria), with and without HPV persistence, were selected. Groups were analyzed by (1) host: clinical disease characteristics; (2) agent: (I) infectious (prevalence, incidence, HPV genotype and co-infections (≥2 HPV genotypes or mycoplasmas)), (II) chemical (contraceptives and immunosuppressive drugs) and (III) physical (vitamin D deficiency) and (3) environment. A total of 121 SLE patients were selected over a two-year period. (1) Host: mean age 45.8 years and disease duration 12.7 years. (2) Agent: (I) infectious. HPV infection prevalence in the second sample was 26.4%, high-risk HPV genotypes 21.5% and co-infections 7.4%. HPV infection incidence was 13.2%, persistence 13.2% and clearance 15.7%. (II) Chemical: use of oral hormonal contraceptives 5% and immunosuppressive treatment 97.5%. (III) Physical: Vitamin D levels were similar in both groups. (3) Environment: (I) natural. A total of 60.6% of patients were residents of Puebla City. (II) Social: The mean education level was 10.9. Poverty levels were: III degree 52.4%, IV degree 28% and II degree 17%. (III) Cultural behavioral: Onset of sexual life was 20.5 years, 10% had ≥3 sexual partners and 51.2% were postmenopausal. In conclusion, no factor of the epidemiologic triad was associated with HPV infection prevalence.

Introduction: Human vitamin D levels have been increasingly related to a wide range of clinical outcomes. There is a large amount of reports on its associations, especially with obstetric complications, including preeclampsia and gestational diabetes. These results are scarcely consistent and there is still a lack of quality intervention studies to confirm the role of vitamin D in those outcomes. Objective: To review the available scientific evidence on the role of maternal vitamin D in the development of preeclampsia., Materials and Methods: The methodology used followed the recommendations of the Cochrane guide for the preparation of systematic reviews, and for metaanalysis, the Guide of the Metaanalysis of Observational Studies in Epidemiology group (MOOSE). The search included both observational studies and controlled clinical trials., Results: Low vitamin D levels, measured by the 25-hydroxyvitamin D test, are common in pregnancy. The results of this systematic review and metaanalysis suggest an inverse ratio between vitamin D levels and the development of preeclampsia. There was heterogeneity among the studies with regard to the design, population, geographic location, definitions of exposure, and the outcome. We excluded randomized controlled trials from this meta-analysis., Conclusion: The inverse association we found suggests that the higher the levels of vitamin D the lesser the probability of developing preeclampsia, in spite of the heterogeneity of the global measurement in this type of analysis.

Introduction: Cancer is a burden in the world, especially for the least developed countries. The Population Registries of Cancer are fundamental in order to know the territorial profiles of cancer, and to evaluate the impact of their control programs., Objective: To estimate the incidence and mortality from cancer in the Metropolitan Area of ​​Bucaramanga in the period 2008-2012., Methods: A descriptive population study of cancer incidence and mortality in the Metropolitan Area of ​​Bucaramanga was conducted. Primary invasive cancer cases from the 2008-2012 period was obtained from the RPC-AMB base. Population and death data were provided by the National Administrative Department of Statistics (DANE, for its initials in Spanish). Crude rates of global and specific incidence and mortality were estimated by sex, and standardized incidence and mortality rates., Results: During the five-year period, 8,775 incidents of cancer were recorded (excluding non-melanoma skin cancer). The global standardized incidence rates per 100,000 person-years were 151.7 in men and 157.2 in women. The main locations were prostate, stomach and colorectal, in men; breast, thyroid and colorectal in women. The standardized mortality rate per 100,000 person-years was 94.8 in men and 78.0 in women., Conclusion: The incidence and mortality rates in most locations are lower than the national ones and those in the previous quinquennium in the Metropolitan Area of ​​Bucaramanga. Thyroid cancer, colorectal cancer, and leukemia show a tendency to increase, which demands further investigation., Competing Interests: Conflict of interest: The authors declare that they have no conflicts of interest. Interests or values ​​different from the usual ones in an investigation have not influenced the elaboration of this manuscript.

Wild plant species with potential for use as ornamental green foliage are often reported. Nevertheless, there are few studies evaluating morphological and anatomical aspects associated with this use. Preliminary trials suggest that the species of Sphaeradenia (Sander ex Mast.) Harling, a Cyclantaceae that occurs from Costa Rica to Peru, is suitable to be used as fresh foliage because of attractiveness of their leaves in vase and its durability without showing tissue damage, compared with other genera of this family. Through the study of anatomical characters, it is possible to predict the potential of a species that can serve as ornamental foliage. In this study, three foliar anatomical features (thickness of the cuticle and leaf, and percentage of fibers in the mesophyll) of seven Cyclanthaceae species were evaluated, using anatomical techniques and image analysis with the LUCIA® and ImageJ softwares. Statistical analysis of the results suggests that this high durability is associated with the thickness of the cuticle and mesophyll, but not with the amount of fibers in the leaf.

Studies regarding stigma towards mental illness in Argentina blossomed after the first National Mental Health Law was passed in 2010. Methodological limitations and contradictory results regarding community perceptions of stigma hinder comparisons across domestic and international contexts but some lessons may still be gleaned. We examine this research and derive recommendations for future research and actions to reduce stigma. These include tackling culture-specific aspects of stigma, increasing education of the general population, making more community-based services available and exposing mental health professionals to people with mental illness who are on community paths to recovery., Competing Interests: Conflict of interest statement: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

The latitudinal extension of southern South America imposes a thermal gradient that affects the structure of marine and freshwater fish assemblages and the biology of the species through direct exposure to the temperature gradients or by means of a web of historical and ecological relationships. We have reviewed biological and ecological data of marine and freshwater fishes from the southern Neotropics, including Patagonia, and report several examples of dependence on temperature, from glacial times to today's climate change. We were able to identify historic and present effects on the diversity of fish assemblages, isolation, southern limits for the distribution of species, and morphological variation among populations. There is a wide range of characteristics that exemplify an adaptation to low temperatures, including biochemical peculiarities, physiological adjustments, and alternative life history patterns, and these appear in both freshwater and marine, and native and exotic fishes. The consequences of stable temperature regimes in both the ocean and thermal streams deserve special mention as these shape specialists under conditions of low selective pressure. At present, habitat use and interactions among species are being subject to changes as consequences of water temperature, and some of these are already evident in the northern and southern hemispheres.

The aim of this work is based in the premise that inorganic arsenic (AsIII) and trivalentmethylated metabolites monomethylarsonous (MMAIII) and dimethylarsinous (DMAIII) participate in DNA damage through the generation of reactive oxygen species (ROS). We have utilized two lymphoblastic lines, Raji (B cells) and Jurkat (T cells), which were treated with the trivalent arsenic species (dose: 0-100 microM) and analyzed by two assays (comet assay and flow cytometry) in the determination of DNA damage and ROS effects in vivo. The results showed that the damage to the DNA and the generation of ROS are different in both cellular lines with respect to the dose of organic arsenic, and the order of damage is MMAIII>DMAIII>AsIII. This fact suggests that the DMAIII is not always the more cytotoxic intermediary xenobiotic, as has already been reported in another study.