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BACKGROUND: Systemic amyloidosis belongs to a group of rare diseases due to extracellular amyloid deposition; it can be classified as primary, secondary or hereditary and there are multiple clinical manifestations depending on the organ affected by amyloid deposition, including heart, kidneys, gastrointestinal tract, musculoskeletal system, nervous system and skin. CLINICAL CASE: A 48-year-old female patient, with no known pathological history, consulted the emergency room due to a one-year history of paresthesias in the upper and lower extremities accompanied by a feeling of weakness, gait disturbance, weight loss, liquid stools, macroglossia, periorbital edema and nodular lesions in the abdomen. The skin biopsy showed the presence of amyloid, which was supported by the positivity of Congo red stain, confirming the diagnosis of systemic amyloidosis and finding an association with multiple myeloma after documenting the Bence-Jones protein and monoclonal involvement of lambda light chains. Chemotherapy was started and treatment was successfully completed. CONCLUSIONS: Systemic amyloidosis is a rare disease that implies a diagnostic challenge. Skin involvement allows clinical suspicion of the disease to make a timely diagnosis and multidisciplinary approach, avoiding complications associated with the amyloid deposition in other organs. [ABSTRACT FROM AUTHOR]

BACKGROUND: Eczema herpeticum is characterized by a monomorphous vesicular rash, produced by the cutaneous dissemination of herpes simplex virus infection. CLINICAL CASE: An elderly female patient with erythrodermic psoriasis who developed eczema herpeticum, a rare complication of this disease and at this age. CONCLUSIONS: Eczema herpeticum may occur at any age, even in older adults, and associated with all types of dermatoses that alter the skin barrier, such as psoriasis; In addition, it may have an atypical manifestation with the absence of vesicles, as in this case. [ABSTRACT FROM AUTHOR]