175 results on '"Gérard Duménil"'
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2. THE CRISIS OF THE EARLY 21st CENTURY: GENERAL INTERPRETATION, RECENT DEVELOPMENTS, AND PERSPECTIVES
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Gérard Duménil and Dominique Lévy
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Economics as a science ,HB71-74 ,Political science (General) ,JA1-92 - Abstract
The current crisis is analyzed as a crisis of "neoliberalism," a social order established in the wake of the structural crisis of the 1970s, to the benefit of upper classes, that is, capitalist and managerial classes. The crisis was the expression of the inner contradictions of this social order. On the one hand, the quest for high income on the part of these classes led to the extraordinary expansion of financial mechanisms and globalization. On the other hand, the US macroeconomy followed an unsustainable trajectory of disequilibrium (as the deficit of foreign trade). This fragile trajectory was destabilized by the subprime crisis. Credit and demand policies were conducted. The crisis entered into a second phase whose main feature was the crisis of sovereign debt. The action (quantitative easing) of the Federal Reserve was spectacular in the United States. In Europe the lack of governance and solidarity slowed down the bailout of the most affected economies, but the consequences on the rate of exchange of the euro remained very limited. The crisis will be long in the old world, though the "national factor" in the United States, confronted with the loss of its international hegemony, could stimulate much more active policies. Many countries in the periphery are now growing more rapidly, defining a new international configuration.
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- 2011
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3. MARXIAN POLITICAL ECONOMY: LEGACY AND RENEWAL
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Gérard Duménil and Dominique Lévy
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Economics as a science ,HB71-74 ,Political science (General) ,JA1-92 - Abstract
The article discusses the relevance of a reference to the framework(s) of analysis of capitalism developed by Marx during the second half of the 19th century in the analysis of contemporary capitalism. The perspective is simultaneously the history of modern human societies and, more technically, the economy of capitalism. The contention is that, in both instances, a Marxian political economy provides the foundations of our understanding, but a number of adjustments are also required. The analysis of modern corporations in Volume III of Capital, with the separation of ownership and management, must be prolonged to present-day institutional features and mechanisms. The homogeneity of wage labor must be broken to incorporate the class foundations of the social divide between managers and other categories of production or clerical workers. The new framework allows for the reassertion of the role of class struggle as the engine of history. Concerning basic concepts, such as the theories of value and capital, or mechanisms, such as competition, the business cycle, and technical and distributional tendencies, the issue is the use of contemporary theoretical and empirical tools, introducing to a process of "sophistication" rather than "revision."
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- 2010
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4. Neoliberalismo: neo-imperialismo Neoliberalism: neo-imperialism
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Gérard Duménil and Dominique Lévy
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Neoliberalismo ,Imperialismo ,Hegemonia ,Neoliberalism ,Imperialism ,Profitability ,Hegemony ,External disequilibria ,Economic history and conditions ,HC10-1085 ,Economics as a science ,HB71-74 - Abstract
O neoliberalismo é uma nova fase do capitalismo, que se impôs a partir do começo dos anos 1980. Considerando seus traços mais gerais nos países do Centro, como nos Estados Unidos e na Europa, destacam-se três características: uma dinâmica mais favorável da mudança tecnológica e da rentabilidade, a criação de rendas a favor das classes mais abastadas, e a redução da taxa de acumulação. O imperialismo na era neoliberal pode se caracterizar pela hegemonia dos Estados Unidos, que drenam fluxos enormes de renda do resto do mundo. Mas esse domínio é solapado pelos desequilíbrios externos crescentes do país, a expressão de uma onda extraordinária de consumo por parte das famílias.Neoliberalism is a new phase of capitalism which was asserted at the beginning of the 1980s. Considering its more general features as in the United States and Europe, it can be characterized by: a more favorable dynamic of technical change and profitability, the creation of income flows to the benefit of the most accommodated classes of the population, and diminished rates of accumulation. A central feature of imperialism in the neoliberal era is U.S. hegemony, a country which is draining huge flows of income from the rest of the world. This domination is, however, undermined by increasing external disequilibria, the expression of an extraordinary wave of consumption from households.
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- 2007
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5. NEOLIBERALISMO-NEOMILITARISMO
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Gérard Duménil and Dominique Lévy
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neoliberalismo ,globalización ,militarismo ,complejo militar-industrial ,Social Sciences ,Economic history and conditions ,HC10-1085 - Abstract
La nueva estrategia militar de los americanos responde a motivaciones políticas, pero también debe entenderse en relación con la situación económica. La economía americana no está en una situación de crisis permanente desde los años setenta aunque las tasas de crecimiento se mantienen comparativamente débiles y existe la amenaza de crisis financiera debida a los factores domésticos y al riesgo de contagio proveniente de la periferia. La participación del gasto militar en el PNN es bajo, y los americanos mantienen capacidad para financiar nuevas guerras. La nueva carrera militar debe ser entendida con un componente del sistema general de las hegemonía americana considerando los intereses de este país en el extranjero
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- 2003
6. Ser keynesiano en el corto plazo y clásico en el largo plazo
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Gérard Duménil and Dominique Lévy
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Economic theory. Demography ,HB1-3840 ,Economic history and conditions ,HC10-1085 - Published
- 1999
7. Capitalisme managérial. Le pourquoi et le comment dans la formation des revenus
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Gérard Duménil and Dominique Lévy
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Economics and Econometrics ,Philosophy ,Sociology and Political Science - Published
- 2022
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8. CHAPTER 5 The Changing Patterns of Income Inequality in the United States, 1917–2017
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Gérard Duménil and Dominique Lévy
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- 2022
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9. The dynamics of capital accumulation in managerial capitalism
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Dominique Lévy and Gérard Duménil
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Capital accumulation ,Economics ,Capitalism ,Neoclassical economics - Published
- 2021
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10. Being Keynesian in the Short Term and Classical in the Long Term: The Traverse to Classical Long-Term Equilibrium
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Gérard Duménil and Dominique Lévy
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- 2021
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11. Synthesis and antileishmanial activities of 4,5-di-substituted acridines as compared to their 4-mono-substituted homologues
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Carole, Di Giorgio, Michel, De Méo, Julien, Chiron, Florence, Delmas, Anna, Nikoyan, Séverine, Jean, Gérard, Dumenil, Pierre, Timon-David, and Jean-Pierre, Galy
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- 2005
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12. Technology and Distribution in Managerial Capitalism: The Chain of Historical Trajectories à la Marx and Countertendential Traverses
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Dominique Lévy and Gérard Duménil
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Sociology and Political Science ,business.industry ,05 social sciences ,Distribution (economics) ,Capitalism ,Neoclassical economics ,0506 political science ,Chain (algebraic topology) ,0502 economics and business ,050602 political science & public administration ,Sociology ,050207 economics ,Social science ,business - Published
- 2016
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13. Thomas Piketty's Historical Macroeconomics: A Critical Analysis
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Gérard Duménil and Dominique Lévy
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Macroeconomics ,050208 finance ,Inequality ,media_common.quotation_subject ,05 social sciences ,Economics, Econometrics and Finance (miscellaneous) ,Measures of national income and output ,Urban land ,Fixed capital ,Capital (economics) ,0502 economics and business ,Political Science and International Relations ,Economics ,National wealth ,050207 economics ,Redistribution of income and wealth ,Productivity ,media_common - Abstract
There has been a great deal of interest in the data on income and wealth inequality collected by Thomas Piketty. This paper does not question that data; rather, it questions the framework of Piketty's analysis, both theoretically and empirically—namely the alleged upward tendency of the ratio of wealth to national income and the rise of wealth inequality. First, in the mechanism put forward, wealth can only grow as a result of savings, thus ruling out any form of price effect (as in urban land). Second, Piketty’s second law defines an asymptotical trajectory, in which variables grow in parallel, something incompatible with the rise of the ratio between two variables. In addition, Piketty’s model does not match data for the USA. The historical profile of the ratio of wealth/national income is actually the inverted image of the productivity of capital (the ratio of output/firms’ fixed capital). Doubts are also expressed concerning the dramatic fall of the ratio of wealth/national income in Europe ar...
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- 2016
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14. Le managérialisme est un mode de production
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Dominique Lévy and Gérard Duménil
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Economics and Econometrics ,Philosophy ,Sociology and Political Science - Abstract
Dans cet entretien consacre a leur livre Managerial Capitalism : Ownership, management and the coming new mode of production (Pluto Press, 2018), G. Dumenil et D. Levy reviennent sur les implications de leur analyse du capitalisme managerial pour l’etude du capitalisme historique, de ses structures de classes fondamentales, et de ses alliances de pouvoirs variables. La these du marxisme traditionnel identifiant les managers a une fraction de classe capitaliste s’en trouve critiquee, de meme que les presupposes vehicules par le concept de « capitalisme d’Etat ». Invites a revenir plus precisement sur leur distinction entre modes de production et « ordres sociaux », comme configurations variables de hierarchies de pouvoirs et d’alliances de classe, les auteurs clarifient les raisons pour lesquelles ils introduisent une nouvelle categorie de mode de production managerial qui impose de repenser le mode de production capitaliste lui-meme suivant une logique de « l’hybridite ». Celle-ci permet de complexifier les tendances du capitalisme historique sur la longue duree, d’approfondir l’analyse de classe du capitalisme managerial, et d’y specifier differentiellement, par rapport au « compromis » d’apres-guerre (caracterise par une alliance entre managers et classes populaires sous la direction des premiers), le dernier ordre social en date caracterise par une alliance « au sommet » entre managers et capitalistes (au detriment des classes populaires) : le neoliberalisme.
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- 2020
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15. Managerial Capitalism
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Gérard Duménil and Dominique Lévy
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- 2018
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16. Marxian Transformation Problem
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Duncan Foley and Gérard Duménil
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- 2018
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17. Managerial Capitalism : Ownership, Management and the Coming New Mode of Production
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Gérard Duménil, Dominique Lévy, Gérard Duménil, and Dominique Lévy
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- Marxian economics, Management--Political aspects, Social classes, Capitalism, Production (Economic theory), Social Class, E´conomie marxiste, Gestion--Aspect politique, Classes sociales, Production
- Abstract
The debate around growing inequality is raging amongst economists, and Marxists are finding new ways to map-out the modern economy. Managerial Capitalism introduces a new way of understanding the changing structure of our economy through the emergence and behaviour of a new class – managers. In the post war years as social democracy reigned, managers tended to form compromises with workers. However, under neoliberalism, allegiances have shifted. Today, a new alliance is forming between managers and capitalist owners, changing the nature of the hierarchy of power under capitalism. Additionally, the authors argue, this is happening much faster and universally than was previously thought. By applying Marx's basic concepts to the reality of the system today, through the use of extensive data sets as well as firmly rooting the argument in its historical context, Managerial Capitalism updates Marxism for the twenty-first century, through showing how the modes of production today are shaped by a new class, that must be understood if it is to be challenged.
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- 2018
18. Welche Geschichte erzählen Pikettys Daten?
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Gérard Duménil and Dominique Lévy
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General Medicine - Published
- 2015
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19. A Reply to William Lazonick’s Comment on our 'Neoliberal Managerial Capitalism: Another Reading of the Piketty, Saez, and Zucman Data'
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Dominique Lévy and Gérard Duménil
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Economics and Econometrics ,Sociology and Political Science ,media_common.quotation_subject ,Neoliberalism ,Context (language use) ,Neoclassical economics ,Capitalism ,Social class ,Shareholder value ,Social order ,Economic inequality ,Income distribution ,Political Science and International Relations ,Economics ,Economic system ,media_common - Abstract
This paper is a reply to William Lazonick’s criticism of our analysis of managerial capitalism and its later phase in neoliberalism, based on the data on income distribution put forward by T. Piketty, E. Saez, and G. Zucman. Two of these criticisms are the expressions of basic misunderstandings. First, we do not believe the managerial revolution occurred against the will of capitalist classes, although, in various later decades, the income and wealth of these classes were dramatically diminished in the New Deal and after World War II. Second, we see in the maximization of shareholder value a central feature of neoliberal capitalism, as Lazonick does. The difference is that we address this feature in the broader context of variegated tendencies jointly expressing the class nature of neoliberalism, a social order targeted toward maximizing the income and wealth of upper classes. What Lazonick says of the taxation of stock options stresses some of the ambiguous features of the distinction between “w...
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- 2015
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20. Neoliberal Managerial Capitalism
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Dominique Lévy and Gérard Duménil
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Economics and Econometrics ,Hegemony ,Sociology and Political Science ,Inequality ,media_common.quotation_subject ,Neoliberalism ,Mode of production ,Capitalism ,Managerialism ,Market economy ,Political Science and International Relations ,Great Depression ,Economics ,Upper class ,media_common - Abstract
The paper first documents income and wealth inequalities since World War I in the United States, a pattern in three stages, with a reduction of inequality since the Great Depression from the high predepression levels, stagnation at diminished levels up to 1980, and a dramatic restoration in neoliberalism. Underlying these three phases, we show the continuous transformation of the composition of the income of the top 1 percent to the benefit of “wages,” testifying to the progress of the managerial aspect of production relations. These trends manifest the ongoing transition toward managerialism, a postcapitalist mode of production with managers as upper class. In the hybrid social formation of managerial capitalism, a tripolar class pattern prevails, namely, capitalists, managers, and popular classes. The three subperiods are interpreted in relation to the configuration (in social orders) of class dominations and alliances, in the first financial hegemony (domination of capitalist classes in allian...
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- 2015
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21. The Neoliberal (Counter-)Revolution
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Gérard Duménil and Dominique Lévy
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- 2017
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22. A reply to Amitava Dutt: the role of aggregate demand in the long run
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Gérard Duménil and Dominique Lévy
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Economics and Econometrics ,Mechanical equilibrium ,law ,Fundamental difference ,Economics ,Investment function ,Neoclassical economics ,Aggregate demand ,Term (time) ,law.invention - Abstract
In an article in this journal, Amitava Dutt comments on our 1999 paper, ‘Being Keynesian in the Short Term and Classical in the Long Term: The Traverse to Classical Long-term Equilibrium’, contending that aggregate demand may affect the long-term equilibrium. We agree to some extent but contend that these mechanisms do not question the fundamental difference between the classical-Marxian perspective (in which u gravitates in the long term around uˉuˉ ) and the post-Keynesian perspective (in which the long-term equilibrium position of u depends on the level of aggregate demand). The basic controversy harks back to Harrod’s investment function, in which the only long-term equilibrium is u = uˉuˉ . We solve the problem of Harrodian instability in reference to the action of monetary authorities and governments. Dutt’s defence of the post-Keynesian investment function is unconvincing.
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- 2014
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23. Le capitalisme managérial
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Gérard Duménil and Dominique Lévy
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General Engineering ,General Earth and Planetary Sciences ,General Environmental Science - Published
- 2019
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24. MODELING MONETARY MACROECONOMICS: KALECKI RECONSIDERED
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Dominique Lévy and Gérard Duménil
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Macroeconomics ,Economics and Econometrics ,Business cycle ,Economics ,Procyclical and countercyclical ,Monetary economics ,Investment (macroeconomics) - Abstract
This study is devoted to the financing of demand out of income and borrowing, a crucial aspect of Kalecki's analysis of investment. If the demand for loans moves procyclically, short-term equilibrium is unstable. The borrowing of non-financial agents must be checked by the action of central banks. Models in which both procyclical and countercyclical mechanisms are considered provide the basis of monetary macroeconomics. Money is neither endogenous nor exogenous but co-determined by the behaviors of financial and non-financial agents. The succession of phases in which the stability of the short-term equilibrium is ensured or not defines an important aspect of the business cycle.
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- 2011
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25. Unproductive Labor as Profit-Rate-Maximizing Labor
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Dominique Lévy and Gérard Duménil
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Labor relations ,Labour economics ,Surplus value ,Physical capital ,Capital accumulation ,Sociology and Political Science ,Economics ,Marxist philosophy ,Capital intensity ,Capitalism ,Profit (economics) - Abstract
Too often, Marxist economists approach the notion of “unproductive labor” negatively. Unproductive labor within enterprises is, however, not useless. Its purpose is the maximization of the profit rate. In Marx's analysis of capital, the entire process is divided into the valorization of capital (the extraction of surplus value) and the circulation of capital. Unproductive labor does not create new value or surplus value, but contributes to the two aspects, increasing surplus value and accelerating the circulation of capital. Thus, the profit rate—the aim of capitalist production—is increased. In Capital, these tasks are introduced as performed by the capitalist, but Marx also explains that, within modern corporations, they are delegated to a salaried personnel: managerial and clerical (also commercial) personnel. As a result of the strong polarization in the division of labor between the two components, managerial and clerical, this analysis leads to a Marxian theory of managerial capitalism.
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- 2011
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26. Les canaux de l’extraction du surtravail dans le capitalisme managerial : hauts salaires et revenus du capital
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Gérard Duménil and Dominique Lévy
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Economics and Econometrics ,Philosophy ,Sociology and Political Science - Abstract
Dans les societes contemporaines avancees, notamment aux Etats-Unis, qui montrent la voie, le principal canal d’extraction du surtravail est devenu le paiement de hauts salaires aux cadres des secteurs prive et public. Correlativement, la hausse des inegalites de revenus au cours des dernieres decennies est surtout due a la croissance des inegalites salariales. Ces tendances manifestent le developpement graduel de relations propres a un nouveau mode de production, le managerialisme, dont la classe dominante est celle des cadres. La notion de « capitalisme managerial » est l’expression de l’hybridite des relations de production actuelles. Les principes fondamentaux de la theorie de l’histoire de Marx sont ainsi preserves au prix d’une « revision » majeure. Ces transformations expliquent pourquoi et comment les propheties du Manifeste relatives a la disparition des societes de classe ne se sont pas realisees : le capitalisme se metamorphose dans une nouvelle societe de classe.
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- 2018
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27. A NOTE ON THE FORMAL TREATMENT OF EXPLOITATION IN A MODEL WITH HETEROGENOUS LABOR
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Gérard Duménil, Dominique Lévy, and Duncan K. Foley
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Value theory ,Microeconomics ,Economics and Econometrics ,Economic data ,Order (exchange) ,Generalization ,Interpretation (philosophy) ,Aggregate (data warehouse) ,Economics ,Purchasing power ,Exchange value - Abstract
The paper presents a formal generalization of Marx's analysis of exploitation and prices in economies in which categories of labor are distinguished according to their unequal ability to create exchange value. Measures of exploitation of categories of labor which are consistent with both the Price of Net Product-Unallocated Purchasing Power (PNP-UPP) (New Interpretation) and the traditional interpretation of Marx's theory of value are defined which aggregate consistently over labor categories and sectors. In order to measure rates of exploitation from real economic data some additional assumption about relative rates of exploitation (which Marx often explicitly assumes to be equal) is required.
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- 2009
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28. Neoliberalism: neo-imperialism
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Dominique Lévy, Gérard Duménil, EconomiX, Université Paris Nanterre (UPN)-Centre National de la Recherche Scientifique (CNRS), Paris-Jourdan Sciences Economiques (PJSE), École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-École des hautes études en sciences sociales (EHESS)-École des Ponts ParisTech (ENPC)-Centre National de la Recherche Scientifique (CNRS), Paris School of Economics (PSE), École des Ponts ParisTech (ENPC)-École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris 1 Panthéon-Sorbonne (UP1)-Centre National de la Recherche Scientifique (CNRS)-École des hautes études en sciences sociales (EHESS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), École normale supérieure - Paris (ENS-PSL), Université Paris 1 Panthéon-Sorbonne (UP1)-École normale supérieure - Paris (ENS-PSL), and Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-École des hautes études en sciences sociales (EHESS)-École des Ponts ParisTech (ENPC)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)
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Hegemony ,Extraordinary wave ,media_common.quotation_subject ,Population ,Neoliberalism ,Neoliberalismo ,Technical change ,0502 economics and business ,Economics ,Hegemonia ,Profitability ,050207 economics ,education ,media_common ,Consumption (economics) ,education.field_of_study ,05 social sciences ,1. No poverty ,Imperialismo ,Imperialism ,Capitalism ,[SHS.ECO]Humanities and Social Sciences/Economics and Finance ,External disequilibria ,Political economy ,8. Economic growth ,Profitability index ,050203 business & management - Abstract
O neoliberalismo é uma nova fase do capitalismo, que se impôs a partir do começo dos anos 1980. Considerando seus traços mais gerais nos países do Centro, como nos Estados Unidos e na Europa, destacam-se três características: uma dinâmica mais favorável da mudança tecnológica e da rentabilidade, a criação de rendas a favor das classes mais abastadas, e a redução da taxa de acumulação. O imperialismo na era neoliberal pode se caracterizar pela hegemonia dos Estados Unidos, que drenam fluxos enormes de renda do resto do mundo. Mas esse domínio é solapado pelos desequilíbrios externos crescentes do país, a expressão de uma onda extraordinária de consumo por parte das famílias. Neoliberalism is a new phase of capitalism which was asserted at the beginning of the 1980s. Considering its more general features as in the United States and Europe, it can be characterized by: a more favorable dynamic of technical change and profitability, the creation of income flows to the benefit of the most accommodated classes of the population, and diminished rates of accumulation. A central feature of imperialism in the neoliberal era is U.S. hegemony, a country which is draining huge flows of income from the rest of the world. This domination is, however, undermined by increasing external disequilibria, the expression of an extraordinary wave of consumption from households.
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- 2007
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29. The Crisis of Neoliberalism
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Gérard Duménil, Gérard Duménil, and Dominique Lévy
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- 2013
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30. Distribution and Genotoxic Effects After Successive Exposure to Different Uranium Oxide Particles Inhaled by Rats
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Sandrine Frelon, Marjorie Monleau, Marie Donnadieu-Claraz, François Paquet, Michel De Méo, Gérard Duménil, V. Chazel, Laboratoire de radiotoxicologie et radiobiologie expérimentale (IRSN/PSE-SANTE/SESANE/LRTOX), Service de recherche sur les effets biologiques et Sanitaires des rayonnements ionisants (IRSN/PSE-SANTE/SESANE), Institut de Radioprotection et de Sûreté Nucléaire (IRSN)-Institut de Radioprotection et de Sûreté Nucléaire (IRSN), Université de la Méditerranée - Aix-Marseille 2, Laboratoire de radiotoxicologie et radiobiologie expérimentale (LRTOX), and Institut de Radioprotection et de Sûreté Nucléaire (IRSN)
- Subjects
Male ,aerosol ,[SDV]Life Sciences [q-bio] ,Health, Toxicology and Mutagenesis ,tissue distribution ,drinking ,animal cell ,010501 environmental sciences ,Kidney ,Toxicology ,01 natural sciences ,Rats, Sprague-Dawley ,Eating ,chemistry.chemical_compound ,dose response ,Uranium oxide ,rat ,animal ,Inhalation exposure ,Inhalation Exposure ,inhalation ,Air Pollutants ,0303 health sciences ,Sprague Dawley rat ,Inhalation ,mutagenic agent ,germfree animal ,drug effect ,article ,Drug Synergism ,Uranium ,Occupational ,Specific Pathogen-Free Organisms ,unclassified drug ,3. Good health ,Dose–response relationship ,bioaccumulation ,priority journal ,classification ,Environmental chemistry ,Bioaccumulation ,Comet Assay ,Drug ,uranium peroxide ,animal experiment ,Uranium dioxide ,chemistry.chemical_element ,Air Pollutants, Occupational ,complex mixtures ,long term exposure ,lung ,Dose-Response Relationship ,body weight ,03 medical and health sciences ,Animals ,controlled study ,030304 developmental biology ,0105 earth and related environmental sciences ,uranium derivative ,Aerosols ,nonhuman ,Dose-Response Relationship, Drug ,drug potentiation ,genotoxicity ,air pollutant ,Radiochemistry ,uranium dioxide ,Uranium Compounds ,Rats ,Comet assay ,chemistry ,exposure ,pathology ,Sprague-Dawley ,gastrointestinal tract ,Mutagens - Abstract
In nuclear fuel cycle facilities, workers may inhale airborne uranium compounds that lead to internal contamination, with various exposure scenarios depending on the workplace. These exposures can be chronic, repeated, or acute, and can involve many different compounds. The effect of uranium after multiple scenarios of exposure is unknown. The aim of this study, therefore, was to investigate the genotoxic and biokinetics consequences of exposure to depleted insoluble uranium dioxide (UO 2 ) by repeated or acute inhalation on subsequent acute inhalation of moderately soluble uranium peroxide (UO 4 ) in rats. The results show that UO 2 repeated preexposure by inhalation increases the genotoxic effects of UO 4 inhalation, assessed by comet assay, in different cell types, when UO 4 exposure alone has no effect. At the same time, the study of UO 4 bioaccumulation showed that the UO 4 biokinetics in the kidneys, gastrointestinal tract, and excreta, but not in the lungs, were slightly modified by previous UO 2 exposures. All these results show that both genotoxic and biokinetics effects of uranium may depend on preexposure and that repeated exposure induces a potentiation effect compared with acute exposure. Copyright © Informa Healthcare.
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- 2006
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31. Genotoxic and Inflammatory Effects of Depleted Uranium Particles Inhaled by Rats
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Marjorie Monleau, Gérard Duménil, V. Chazel, Michel De Méo, François Paquet, Marie Donnadieu-Claraz, Laboratoire de radiotoxicologie et radiobiologie expérimentale (IRSN/PSE-SANTE/SESANE/LRTOX), Service de recherche sur les effets biologiques et Sanitaires des rayonnements ionisants (IRSN/PSE-SANTE/SESANE), Institut de Radioprotection et de Sûreté Nucléaire (IRSN)-Institut de Radioprotection et de Sûreté Nucléaire (IRSN), Université de la Méditerranée - Aix-Marseille 2, Laboratoire de radiotoxicologie et radiobiologie expérimentale (LRTOX), and Institut de Radioprotection et de Sûreté Nucléaire (IRSN)
- Subjects
Male ,[SDV]Life Sciences [q-bio] ,Gene Expression ,radiation exposure ,animal cell ,010501 environmental sciences ,Pharmacology ,Kidney ,Toxicology ,medicine.disease_cause ,Bronchoalveolar Lavage ,01 natural sciences ,Rats, Sprague-Dawley ,Fibrosis ,cytokine ,kidney cell ,oxidative stress ,rat ,correlation function ,lung alveolus cell ,DNA strand breakage ,Inhalation Exposure ,0303 health sciences ,Inhalation ,Chemistry ,nephrotoxicity ,article ,Specific Pathogen-Free Organisms ,3. Good health ,hydroperoxide ,Uranium ,Cytokines ,Comet Assay ,medicine.symptom ,radiation dose ,Bronchoalveolar Lavage Fluid ,Radioactive Pollutants ,DNA damage ,animal experiment ,Industrial Waste ,Inflammation ,Respiratory Mucosa ,animal tissue ,in vivo study ,03 medical and health sciences ,In vivo ,medicine ,Animalia ,Animals ,controlled study ,protein expression ,030304 developmental biology ,0105 earth and related environmental sciences ,lung toxicity ,nonhuman ,animal model ,solubility ,genotoxicity ,uranium dioxide ,Epithelial Cells ,DNA ,Hydrogen Peroxide ,medicine.disease ,Rats ,Comet assay ,inflammation ,13. Climate action ,Immunology ,Sprague-Dawley ,Oxidative stress ,Genotoxicity ,Mutagens - Abstract
Depleted uranium (DU) is a radioactive heavy metal coming from the nuclear industry and used in numerous military applications. Uranium inhalation can lead to the development of fibrosis and neoplasia in the lungs. As little is known concerning the molecular processes leading to these pathological effects, some of the events in terms of genotoxicity and inflammation were investigated in rats exposed to DU by inhalation. Our results show that exposure to DU by inhalation resulted in DNA strand breaks in broncho-alveolar lavage (BAL) cells and in increase of inflammatory cytokine expression and production of hydroperoxides in lung tissue suggesting that the DNA damage was in part a consequence of the inflammatory processes and oxidative stress. The effects seemed to be linked to the doses, were independent of the solubility of uranium compounds and correlating with the type of inhalation. Repeated inhalations seemed to induce an effect of potentiation in BAL cells and also in kidney cells. Comet assay in neutral conditions revealed that DNA damage in BAL cells was composed partly by double strands breaks suggesting that radiation could contribute to DU genotoxic effects in vivo. All these in vivo results contribute to a better understanding of the pathological effect of DU inhalation. © The Author 2005. Published by Oxford University Press on behalf of the Society of Toxicology. All rights reserved.
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- 2005
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32. El imperialismo en la era neoliberal
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Gérard Duménil and Dominique Lévy
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- 2005
33. The economics of US imperialism at the turn of the 21st century
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Dominique Lévy and Gérard Duménil
- Subjects
Rate of return ,Economics and Econometrics ,education.field_of_study ,Sociology and Political Science ,Population ,Foreign direct investment ,Portfolio investment ,External debt ,Market economy ,Political Science and International Relations ,Economics ,Remuneration ,Dividend ,education ,Stock (geology) - Abstract
At the turn of the 21st century, US imperialism appears very strong. The paper focuses on economic mechanisms. Both direct investment abroad and portfolio investment contribute extensively to the remuneration of capital in the United States, under the form of interest, dividends and profits of transnational corporations retained abroad. The rates of return on these investments are high, in particular when compared to the returns of foreigners when they invest in the United States. The major contradiction results from the growing external trade imbalance. The outflow of dollars to the rest of the world is invested back in the country by foreigners. Their stock of assets on the United States is now the double of the stock of assets of this country on the rest of the world; the flow of income paid to foreigners is equal to that received from the rest of the world. These deficits are due to the tremendous wave of consumption by the richest fraction of the population, which followed the restoration of the inco...
- Published
- 2004
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34. The Real and Financial Components of Profitability (United States, 1952–2000)
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Dominique Lévy and Gérard Duménil
- Subjects
Finance ,Economics and Econometrics ,Profit rate ,business.industry ,05 social sciences ,0506 political science ,Competition (economics) ,Philosophy ,0502 economics and business ,Value (economics) ,050602 political science & public administration ,Economics ,Profitability index ,Stock market ,Prices of production ,050207 economics ,Real interest rate ,business ,Financial sector - Abstract
Financial relations considerably alter the profile of the profit rate of nonfinancial corporations. Large rates are maintained to the end of the 1970s. Conversely, rates are diminished during the 1980s and 1990s. The average value of the profit rate of the financial sector is similar, though lower during the 1970s, due to low real interest rates and a stagnating stock market. The opposite is true during the neoliberal decades.
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- 2004
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35. Implication of nitro group reduction in the mutagenic and chromosome damaging activities of 22 new 5-nitroisoquinolines by the Salmonella mutagenicity test and the cytokinesis-blocked micronucleus assay
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Marcel Castegnaro, P Rathelot, M.P. De Méo, M Galas, J. Pompili, P Vanelle, Thierry Orsière, and Gérard Duménil
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Adult ,Male ,Ribosomal Proteins ,Salmonella typhimurium ,congenital, hereditary, and neonatal diseases and abnormalities ,Salmonella ,Adolescent ,Stereochemistry ,DNA damage ,Nitro compound ,Toxicology ,medicine.disease_cause ,Rats, Sprague-Dawley ,Nitroreductase ,medicine ,Animals ,Humans ,Lymphocytes ,Aged ,Chromosome Aberrations ,chemistry.chemical_classification ,Micronucleus Tests ,Dose-Response Relationship, Drug ,Ribosomal Protein S9 ,General Medicine ,Middle Aged ,Isoquinolines ,Nitro Compounds ,Molecular biology ,Rats ,chemistry ,Reducing Agents ,Acetyltransferase ,Micronucleus test ,Female ,Micronucleus ,Genotoxicity ,Mutagens ,Food Science - Abstract
The mutagenic (MUT) and chromosome-damaging (CHR) activities of 22 potential antimalarial drugs (5-nitroisoquinoline derivatives) were evaluated by the Salmonella test and the cytokinesis-blocked micronucleus assay (CBMN). The Salmonella mutagenicity test was performed with and without metabolic activation (S9 mix) in S. typhimurium strains TA100 and YG1042 (an overproducing nitroreductase and O -acetyltransferase TA100 strain). The CBMN was carried out on human lymphocytes without metabolic activation. Four concentrations were tested: 1, 10, 100 and 1000 ng/ml. MUT was expressed as minimal mutagenic concentrations (MMC, μ m ) and CHR was expressed as minimal chromosome-damaging concentrations (MCDC, n m ) to compare both activities. All the 5-nitroisoquinoline compounds were mutagenic in TA100. MMC ranged from 0.1 to 52.9 μ m in TA100. A statistically significant decrease in MMC was observed in YG1042 (8×10 −3 to 3.5 μ m ), implicating reduction of the nitro group. Modulation of MUT by S9 mix was not significant in TA100 and YG1042. CHR was detected in 13 products for at least one concentration. Among the chromosome-damaging compounds, the MCDC ranged from 2.9×10 −3 to 3.6 n m . No relationship was found between MUT and CHR, suggesting two distinct pathways of DNA damage.
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- 2003
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36. The profit rate: where and how much did it fall? Did it recover? (USA 1948-2000)
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Dominique Lévy and Gérard Duménil
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Net profit ,Profit rate ,Economics and Econometrics ,05 social sciences ,0506 political science ,Philosophy ,Economy ,Gross profit ,0502 economics and business ,Profit margin ,Economics ,050602 political science & public administration ,050207 economics ,Humanities - Abstract
Resume La baisse du taux de profit depuis la Seconde Guerre mondiale est maintenant un phenomene largement reconnu, et l’existence d’une nouvelle tendance a la hausse est desormais identifice. Cette etude propose de nouvelles estimations du taux de profit dans une definition proche de celle utilisee par Marx au livre III du Capital, ou les profits correspondent a la plus-value totale, et une definition plus proche de la pratique des entreprises, prenant en compte les interets, les impots et les stocks. On montre que les taux de profit d’un sous-ensemble de branches (comme les Chemins de fer), dont le rapport capital-travail est particulierement eleve et qu’on nomme branches hautement capitalistiques, sont tout a fait differents de ceux des autres branches, tant en niveau qu’en tendance (leur taux de profit est tres bas et n’a pas baisse). La baisse du taux de profit et sa remontee partielle peuvent etre plus clairement saisies, lorsque ces branches sont eliminees. Au total, entre 1948 et 1982, le taux de profit fut divise par un coefficient compris entre 2 et 7, selon les secteurs et les definitions du taux de profit consideres. En 2000, le taux profit n’a encore retrouve que la moitie de sa valeur de 1948. On montre enfin que la baisse de la productivite du capital fut le principal facteur de la chute du taux de profit, bien que la baisse de la part des profits ait egalement contribue a cette evolution.
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- 2002
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37. Manufacturing and global turbulence: Brenner's misinterpretation of profit rate differentials
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Gérard Duménil and Dominique Lévy
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Economics and Econometrics ,Philosophy ,Profit rate ,Market economy ,business.industry ,Manufacturing ,Economics ,Capital intensity ,Marxist philosophy ,Classical economics ,business ,Profit (economics) ,Technical change - Abstract
Robert Brenner's analysis of the structural crisis of the late 20th century, in his Economics of Global Turbulence, is based on the observation of the decline of the profit rate, as is common among Marxist economists. Instead of the usual reference to the features of technical change, Brenner explains the decline of the profit rate in the whole economy by its fall within manufacturing industries, resulting from excess international competition. Brenner's basic insight is based on the observation that, after World War II, in the United States, the profit rate of manufacturing industries was larger than in other U.S. industries, and declined considerably more. This observation follows from a misinterpretation of profit rate differentials. Actually, the profit rate of manufacturing industries was not significantly different from that of most other industries, with the exception of a group of very capital intensive industries such as railroads, which accounts for only 13 percent of total output. This difference, which remains to be explained, has nothing to do with international competition.
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- 2002
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38. The crisis of the early 21st Century: Marxian perspectives
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Dominique Lévy and Gérard Duménil
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Economy ,Keynesian economics ,Debt ,media_common.quotation_subject ,Financial fragility ,Economics ,Monetary reform ,Global imbalances ,Asset (economics) ,Post-Keynesian economics ,Capitalism ,Public finance ,media_common - Abstract
The current crisis is one of the great crises punctuating the long history of capitalism, and to be properly understood it is vital to take into account its ongoing structural transformation. This book offers plural perspectives on the Great Recession, placing the analysis of finance, class and gender at the center of the debate. It begins with a comprehensive insight into the crisis, before moving on to focus on debt, asset inflation and financial fragility. Following chapters discuss global imbalances, structural monetary reform and the management of public finance, including a investigation of the Italian experience. The book concludes with novel contributions on the gender dimension of the crisis and the analogies between a nuclear and financial chain reaction.
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- 2014
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39. La grande bifurcation
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Dominique Lévy and Gérard Duménil
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- 2014
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40. À propos de la grande bifurcation. En finir avec le néolibéralisme
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Gérard Duménil, Dominique Lévy, Bruno Tinel, Centre d'économie de la Sorbonne (CES), Université Panthéon-Sorbonne (UP1)-Centre National de la Recherche Scientifique (CNRS), Paris School of Economics (PSE), Paris-Jourdan Sciences Economiques (PSE), Centre National de la Recherche Scientifique (CNRS)-École des Ponts ParisTech (ENPC)-École des hautes études en sciences sociales (EHESS)-Institut National de la Recherche Agronomique (INRA)-École normale supérieure - Paris (ENS Paris), Centre National de la Recherche Scientifique (CNRS)-Université Panthéon-Sorbonne (UP1), and École normale supérieure - Paris (ENS Paris)-Institut National de la Recherche Agronomique (INRA)-École des hautes études en sciences sociales (EHESS)-École des Ponts ParisTech (ENPC)-Centre National de la Recherche Scientifique (CNRS)
- Subjects
Economics and Econometrics ,European level ,Sociology and Political Science ,Neoliberalism (international relations) ,World War II ,neoliberalism ,[SHS.ECO]Humanities and Social Sciences/Economics and Finance ,classes ,structures of ownership ,Power (social and political) ,Philosophy ,Social order ,Alliance ,crisis ,Economy ,Sociology ,capitalism - Abstract
International audience; Bruno Tinel questions Duménil and Lévy (DL) about their new book, La Découverte. Besides the paths currently taken by the United-States and Europe in the wake of the 2008 crisis --the continuation of a dynamics weighted in favour of upper classes --there is an alternative path to the left that is here opened up : hence the "bifurcation". DL go further in their Marxist-inspired diagnosis. Neoliberalism is described as a social order strategically biased to the power and income of capitalist classes and their allies, the managerial classes. The book draws a contrast between American-English neoliberalism and the configurations observed in Europe. A series of new findings provides the basis for a concrete analysis of the worldwide structures of ownership and control ; the crisis in Europe is investigated by way of the contrasting trajectories of France and Germany, while special emphasis is placed on the Spanish economy. DL argue that, as was the case in the decades immediately following World War II, a new alliance between popular and managerial classes is required, to be established at a European level, but with the aim of transcending the latter level.
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- 2014
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41. The expression of genes induced in melanocytes by exposure to 365-nm UVA: study by cDNA arrays and real-time quantitative RT-PCR
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Thierry Orsière, Laurence Bellon, J.L. Bergé-Lefranc, Chantal Bideau, Michel De Méo, Alain Botta, Gérard Duménil, Gilles Halimi, and Séverine Jean
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DNA Repair ,Ultraviolet Rays ,DNA damage ,Biophysics ,Biology ,Polymerase Chain Reaction ,Biochemistry ,Structural Biology ,Gene expression ,Genetics ,medicine ,Humans ,Gene ,Transcription factor ,Oligonucleotide Array Sequence Analysis ,Regulation of gene expression ,Reverse Transcriptase Polymerase Chain Reaction ,Gadd45 ,Melanoma ,Cell Differentiation ,medicine.disease ,Molecular biology ,Real-time polymerase chain reaction ,Gene Expression Regulation ,Genes ,Melanocytes ,sense organs ,Cell Division - Abstract
Ultraviolet A radiation (UVA; 320–400 nm) constitutes more than 90% of the terrestrial UV solar energy. This type of radiation generates reactive oxygen species and consequently induces DNA damage. UVA irradiation is now considered to be an important carcinogen agent especially in the development of melanoma. UVA radiation is known to activate several pathways in mammalian cells. We have used cDNA arrays to analyze differential gene expression in primary cultures of human melanocytes in response to 365-nm UVA. Among 588 genes studied, 11 were overexpressed. These genes included genes involved in cell cycle regulation (GADD45, CIP1/WAF1), in stress response (HSP70, HSP40, HSP86), in apoptosis (GADD153, tristetraproline) and genes encoding transcription factors (EGR-1, ETR-101, c-JUN, ATF4). This coordinate gene regulation was confirmed by real-time quantitative RT-PCR.
- Published
- 2001
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42. Brenner on Competition
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Dominique Lévy, Gérard Duménil, and Mark Glick
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Economics and Econometrics ,History ,Profit rate ,Sociology and Political Science ,05 social sciences ,0506 political science ,Competition (economics) ,Extension (metaphysics) ,Market economy ,0502 economics and business ,050602 political science & public administration ,Economics ,050207 economics ,Falling (sensation) - Abstract
This paper criticizes Brenner's emphasis on competition within Manufacturing in his analysis of the falling profit rate, and the subsequent extension of this fall to the entire economy. His assumptions concerning price competition appear arbitrary and proofs are deficient. Brenner cannot escape the reliance on the rise of wages, contrary to what he contends in his criticism of profit-squeeze theory. Several basic theoretical issues, such as adjustment by prices (as in neoclassical models) or by quantities produced (as in Keynesian models), partial or general analysis are not treated properly. For Marx, the decline of the profit rate causes competitive wars; the inverse relationship is posited by Brenner.
- Published
- 2001
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43. Costs and benefits of neoliberalism. A class analysis
- Author
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Dominique Lévy and Gérard Duménil
- Subjects
Economics and Econometrics ,Hegemony ,Class analysis ,Sociology and Political Science ,Compromise ,media_common.quotation_subject ,World War II ,Debt ,Political economy ,Political Science and International Relations ,Unemployment ,Economics ,Great Depression ,Ideology ,media_common - Abstract
Neoliberalism is the ideological expression of the return to hegemony of the financial fraction of ruling classes. The meaning of this movement can only be understood from a historical perspective. Modern finance, linked to the real economy, appeared in the wake of the structural crisis of the late nineteenth century. It lost its unrivalled domination, when the Keynesian compromise was ushered in by the succession of the great depression and World War II. Its return to power followed the crisis which began in the 1970s. The class character of neoliberalism is evident from an examination of the available figures. It prolonged the deficient profit rates of non-financial corporations and, thus, slow growth and unemployment. It was responsible for the deficits and the growing indebtedness of the states, as well as for the crisis of the debt of Third World countries, etc. But not enough attention has been paid to the benefits that finance gleaned from its return to hegemony during the crisis: the stunning rise...
- Published
- 2001
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44. The Conservation of Value: A Rejoinder to Alan Freeman
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Dominique Lévy and Gérard Duménil
- Subjects
Economics and Econometrics ,Keynesian economics ,Disequilibrium ,05 social sciences ,Devaluation ,Neoclassical economics ,Fixed capital ,Technical change ,0506 political science ,Philosophy ,Physical capital ,0502 economics and business ,Economics ,medicine ,050602 political science & public administration ,Criticism ,medicine.symptom ,050207 economics ,Labor theory of value - Abstract
This paper is a critique of Alan Freeman's theory of sequential values. In this approach value is conserved from period to period independently of technical change and disequilibrium, contrary to the traditional view that values are reevaluated at each period depending on the existing conditions of production. Our main criticism is that sequential values fail to account for the devaluation of capital, when the economy is considered globally. Devaluation is possible for individual commodities in Freeman's framework, but the loss of value is always compensated by a corresponding gain for another commodity. The paper also points out a number of puzzling properties of sequential values, in particular the compatibility of increasing values with rising labor productivity. The unusual treatment of fixed capital, in which fixed capital is assimilated to an imperishable raw material, also raises serious problems for Freeman.
- Published
- 2000
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45. Being Keynesian in the Short Term and Classical in the Long Term: The Traverse to Classical Long-Term Equilibrium
- Author
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Dominique Lévy and Gérard Duménil
- Subjects
Inflation ,Economics and Econometrics ,Traverse ,Capital (economics) ,Keynesian economics ,media_common.quotation_subject ,Monetary policy ,Economics ,Capacity utilization ,Prices of production ,Investment (macroeconomics) ,Term (time) ,media_common - Abstract
We analyse the relationship between the Keynesian (post-Keynesian, Kaleckian) and classical perspectives, emphasizing the distinction between two time frames, short term and long term. A model is presented in which the traverse to a long-term classical equilibrium, with prices of production, is obtained as a sequence of short-term Keynesian equilibria (in which outputs are adjusted to demands). In the short term, prices and capital stocks are constant; they are only adjusted in the long term. Prices respond to disequilibria concerning capacity utilization rates. Investment is subject to a financing constraint, in which the provision of loans by the banking system is involved. Loans are modified in response to inflation (monetary policy).
- Published
- 1999
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46. The protective activity of α-hederine against H2O2 genotoxicity in HepG2 cells by alkaline comet assay
- Author
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M De Méo, C Mba Gachou, Michèle Laget, H. Guiraud-Dauriac, Gérard Duménil, and R. Elias
- Subjects
Antioxidant ,Health, Toxicology and Mutagenesis ,medicine.medical_treatment ,Protective Agents ,medicine.disease_cause ,chemistry.chemical_compound ,Tumor Cells, Cultured ,Genetics ,medicine ,Humans ,Oleanolic Acid ,Electrophoresis, Agar Gel ,Dose-Response Relationship, Drug ,biology ,Mutagenicity Tests ,Cell Membrane ,Proteins ,DNA, Neoplasm ,Hydrogen Peroxide ,Glutathione ,Saponins ,Carbohydrate ,Catalase ,Molecular biology ,Comet assay ,chemistry ,Biochemistry ,Toxicity ,biology.protein ,Oxidation-Reduction ,Antimutagen ,Genotoxicity ,DNA Damage - Abstract
This study was designed to evaluate the protective effect of alpha-hederine (alpha-hed) against H2O2-mediated DNA damage on HepG2 cell line by the alkaline comet assay. For the protective effect of alpha-hed study, cells were treated according to three protocols: pre-treatment, simultaneous treatment and post-treatment. The effect of alpha-hed on catalase activity was evaluated after treating the cells with 3.36 mg/ml of 3-amino-1,2,4-triazole (AMT) singly or in combination with alpha-hed (1.5 or 3 microg/ml) and H2O2 (8.8 microM) during 1 h. The catalase activity was also biochemically measured after treating cells with alpha-hed at 1.5, 3, or 15 microg/ml during 1 h. Additionally, the influence of alpha-hed on membrane RedOx potential, pool of reduced glutathione and total protein content was evaluated by flow cytometry. In the pre-treatment, the two concentrations of alpha-hed (1.5 and 3 microg/ml) decreased the lesions induced by H2O2 (8.8 microM) significantly. This decrease was about 57.2% and 66.1%, respectively. Similar results were observed when cells were treated with alpha-hed and H2O2 simultaneously. The decrease of H2O2-induced lesions was about 78.2% and 83.2% (alpha-hed 1.5 and 3 microg/ml, respectively). In the post-treatment protocol, this decrease was not significant. The combination of AMT and H2O2 induced more DNA damage than H2O2 alone (tail moment (TM) means was 31.4% and 21.8%, respectively). When alpha-hed was added to this mixture, TM means were reduced significantly (17.4% for alpha-hed 1. 5 microg/ml and 15.5% for alpha-hed 3 microg/ml). Up to 6.9 microg/ml, alpha-hed enhanced catalase activity (60.5%), followed by a decrease of the activity. Total protein content and membrane RedOx potential were slightly increased up to 11 microg/ml (14% and 3.6%, respectively) followed by a drop and a plateau. Pool of reduced glutathione remained unchanged up to 10 microg/ml then dropped and reached a plateau. In conclusion, alpha-hed could exert its protective effect against H2O2-mediated DNA damage by scavenging free radicals or by enhancing the catalase activity.
- Published
- 1999
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47. Brenner on Distribution
- Author
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Dominique Lévy and Gérard Duménil
- Subjects
History ,Profit rate ,Sociology and Political Science ,business.industry ,Political Science and International Relations ,Distribution (economics) ,Sociology ,business ,General Economics, Econometrics and Finance ,Mathematical economics ,Social Sciences (miscellaneous) ,Implicit personality theory - Abstract
This paper discusses one important component of the analysis of the decline of the profit rate in recent decades in Robert Brenner's Economics of Global Turbulence. Our single focus in this paper is Brenner's implicit theory of distribution.
- Published
- 1999
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48. Evaluation of the mutagenicity and antimutagenicity of forty-two 3-substituted flavones in the Ames test
- Author
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C. Beudot, Michèle Laget, Guy Balansard, M De Méo, R. Elias, Gérard Duménil, D. Dauzonne, and H. Guiraud
- Subjects
Flavonoids ,Salmonella typhimurium ,chemistry.chemical_classification ,endocrine system ,Mutagenicity Tests ,Chemistry ,Stereochemistry ,Health, Toxicology and Mutagenesis ,fungi ,Mutagenesis ,food and beverages ,Antimutagenic Agents ,Flavones ,Ames test ,Toxicology ,Nitroreductase ,chemistry.chemical_compound ,Polyphenol ,Acetyltransferase ,Genetics ,Pyrene ,Antimutagen ,Mutagens - Abstract
The mutagenic and antimutagenic activities of forty-two synthetic flavones were assessed by the Ames test. The tested flavones included twenty-three 3-nitroflavones, eighteen 3-aminoflavones and the 3-chloroflavone. The mutagenicity was evaluated with Salmonella typhimurium TA100 and YG1042 (an overproducing nitroreductase and O -acetyltransferase TA100 strain) with and without metabolic activation (S9 mix). The antimutagenicity of the non mutagenic derivatives was evaluated against 11 known reference mutagens. A total of 39 synthetic flavones were mutagenic. The mutagenic activities ranged from 0.1 rev/nmole (4′-chloro-6-methoxy-3-nitroflavone) to 6240 rev/nmole (4′-methoxy-3,3′-diaminoflavone). Two differences were found between the 3-amino and the 3-nitroflavones: (i) the mutagenicity of the 3-aminoflavones required the presence of the metabolic activation; (ii) the 3-amino derivatives were more mutagenic than their 3-nitro counterparts. Increased mutagenicity, as assessed with strain YG1042, was limited to 17/39 derivatives. The mutagenic activity was induced by the presence of the double bond at the 2,3-position for conjugation of the lone-pair electron with the carbonyl group on the `C' ring. This mutagenicity was modulated by substituents at the 2′-position. Additional mutagenicity was brought by the aminoaromatic and nitroaromatic group reduction by bacterial nitroreductases and by the S9 mix; it was modulated by different substituents on the aromatic rings of the flavones. Three flavones: 3-chloroflavone ( 1C ), 4′-hydroxy-3-nitroflavone ( 23N ) and 2′,3-diaminoflavone ( 2A ) showed antimutagenic properties. Compound 1C was efficient against benzo( a )pyrene (BaP), 2-aminofluorene (2AF), 2-aminoanthracene (2AA), 4-nitroquinoline-1-oxide (4NQO) and 1-methyl-3′-nitro-1-nitrosoguanidine (MNNG). Compound 23N inhibited the mutagenicity of BaP and MNNG. The antimutagenic activity of 2A was limited to MNNG.
- Published
- 1998
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49. Capital Allocation Under a Financial Constraint: The Classical Investment Function
- Author
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Dominique Lévy and Gérard Duménil
- Subjects
Microeconomics ,Economics and Econometrics ,Rational expectations ,Return on investment ,Capital (economics) ,Economics ,Capital employed ,Profitability index ,Investment function ,Investment (macroeconomics) ,Capital allocation line - Abstract
In the modern literature on investment, a distinction is normally made between neo-Classical and Keynesian theories of investment. An earlier original approach can, however, be located in the works of Smith, Ricardo, and Marx. In this Classical tradition, investment is subject to a capital constraint, and capitalists allocate their capital according to the relative profitability of the various industries. We show that this behaviour is rational in a model in which capitalists optimize over an infinite horizon and form rational expectations: inter-industry mobility can be expressed as an adjustment behaviour such that investments, ΔKi are proportional to profitability differentials: ΔKi = Ai (r¯i−r¯)
- Published
- 1998
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50. Evaluation of a flow cytofluorometric method for rapid determination of amphotericin B susceptibility of yeast isolates
- Author
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Christiane Chastin, F Peyron, H. Guiraud-Dauriac, P Regli, M El Mzibri, A Favel, and Gérard Duménil
- Subjects
Antifungal Agents ,Time Factors ,Microbial Sensitivity Tests ,Microbiology ,Flow cytometry ,Amphotericin B ,medicine ,Pharmacology (medical) ,IC50 ,Candida ,Pharmacology ,Reproducibility ,Chromatography ,biology ,medicine.diagnostic_test ,Computers ,Fungi imperfecti ,Flow Cytometry ,biology.organism_classification ,Yeast ,Fluorescence intensity ,Infectious Diseases ,Evaluation Studies as Topic ,Candida spp ,Regression Analysis ,Research Article ,medicine.drug - Abstract
A rapid-flow cytofluorometric susceptibility test for in vitro amphotericin B testing of yeasts was evaluated and compared to the National Committee for Clinical Laboratory Standards (NCCLS) M27-T reference broth macrodilution method. The flow cytofluorometric method is based on the detection of decreased green fluorescence intensity of cells stained with DiOC5(3), a membrane potential-sensitive cationic dye, after drug treatment. Testing was performed on 134 clinical isolates (Candida spp. and Torulopsis glabrata). From the dose-response curve obtained for each isolate, three endpoints were calculated by computer analysis (the concentrations at which the fluorescence intensity was reduced by 50, 80, and 90%, i.e., 50% inhibitory concentration [IC50], IC80, and IC90, respectively). A regression analysis correlating these endpoints with the M27-T MICs showed that the best agreement was obtained with IC80. The flow cytofluorometric method showed good reproducibility with control strains. These initial results suggest that the flow cytofluorometric method is a valid alternative to the NCCLS reference method.
- Published
- 1997
- Full Text
- View/download PDF
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