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2. Early Experience with the New Ovation Alto Stent Graft in Endovascular Abdominal Aortic Aneurysm Repair

Author

G. Palasciano, Giuseppe Galzerano, Claudia Panzano, Edoardo Pasqui, Gianmarco de Donato, and Alessandro Cappelli

Subjects
medicine.medical_specialty, Aortic aneurysm, O-ring, Endovascular, RD1-811, business.industry, medicine.medical_treatment, Short Report, Stent, medicine.disease, Abdominal aortic aneurysm, Surgery, Polymer based stent graft, RC666-701, medicine, Diseases of the circulatory (Cardiovascular) system, EVAR, Cardiology and Cardiovascular Medicine, business
Abstract

Introduction Since 2010, the Ovation Abdominal Stent Graft System has offered a new sealing concept, achieved by a sealing ring filled with polymer 13 mm from the renal arteries. In the latest version, called Ovation Alto, the sealing ring is relocated 6 mm closer to the top of the fabric. This study describes the early clinical outcomes, after CE Mark approval in August 2020, of endovascular aneurysm repair with the Alto endograft. Report Eleven patients underwent endovascular aneurysm repair with implantation of Ovation Alto endografts. All patients were male, and the median age was 75 (IQR 5.5) years. Hostile proximal aortic neck (, Highlights • This paper describes the early clinical outcomes with the Ovation Alto stent graft, after CE Mark approval in August 2020. • Procedural technical success and a six month success of 100%. • Technical improvements are that the stent graft may now accommodate a more comprehensive range of anatomies on label.

Published
2022

3. Unexpected discovery of massive liver echinococcosis. A clinical, morphological, and functional diagnosis

Author

L. Bonfrate, F. Giuliante, G. Palasciano, J.T. LaMont, and P. Portincasa, M.D., Ph.D.

Subjects
Liver mass, Ultrasonography, Zoonosis, Hydatidosis, Specialties of internal medicine, RC581-951
Abstract

We report a case of symptomatic massive liver echinococcosis due to Echinococcus granulosus, unexpectedly found in a 34 year old woman living in Apulia, Italy. Based on size (max diameter 18 cm), clinical presentation, geographical area, and natural history of echinococcosis, we estimate that the initial infection should have occurred 9-20 yrs before. Presenting symptoms were those of typical mass effect with RUQ pain, pruritus, malaise, and recent weight loss. Abdominal ultrasound diagnosis of probable echinococcal cyst was subsequentely confirmed by positive serology and further detailed by radiological imaging. The cyst was massively occupying subdiaphragmatic liver segments and extending to the omentum and the stomach. The characteristics of the lesion were compatible with the WHO 2003 classification type CE2l, indicating a large active fertile cyst with daughter cysts. The cyst was successfully treated with medical therapy followed by surgery. The prevalence, diagnostic workup, management, and costs of echinococcosis are discussed in this case presentation.

Published
2013
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4. Long- and short-range correlations and their event-scale dependence in high-multiplicity pp collisions at s=13 TeV

Author

Acharya, S. Adamova, D. Adler, A. Adolfsson, J. Aglieri Rinella, G. Agnello, M. Agrawal, N. Ahammed, Z. Ahmad, S. Ahn, S. U. Akbar, Z. Akindinov, A. Al-Turany, M. and Albuquerque, D. S. D. Aleksandrov, D. Alessandro, B. and Alfanda, H. M. Alfaro Molina, R. Ali, B. Ali, Y. Alici, A. Alizadehvandchali, N. Alkin, A. Alme, J. Alt, T. and Altenkamper, L. Altsybeev, I. Anaam, M. N. Andrei, C. and Andreou, D. Andronic, A. Anguelov, V. Anticic, T. and Antinori, F. Antonioli, P. Anuj, C. Apadula, N. and Aphecetche, L. Appelshaeuser, H. Arcelli, S. Arnaldi, R. and Arratia, M. Arsene, I. C. Arslandok, M. Augustinus, A. and Averbeck, R. Aziz, S. Azmi, M. D. Badala, A. Baek, Y. W. and Bai, X. Bailhache, R. Bala, R. Balbino, A. and Baldisseri, A. Ball, M. Banerjee, D. Barbera, R. and Barioglio, L. Barlou, M. Barnafoeldi, G. G. Barnby, L. S. and Barret, V. Bartels, C. Barth, K. Bartsch, E. and Baruffaldi, F. Bastid, N. Basu, S. Batigne, G. Batyunya, B. Bauri, D. Bazo Alba, J. L. Bearden, I. G. Beattie, C. and Belikov, I. Bell Hechavarria, A. D. C. Bellini, F. and Bellwied, R. Belokurova, S. Belyaev, V. Bencedi, G. and Beole, S. Bercuci, A. Berdnikov, Y. Berdnikova, A. and Berenyi, D. Bergmann, L. Besoiu, M. G. Betev, L. and Bhaduri, P. P. Bhasin, A. Bhat, I. R. Bhat, M. A. and Bhattacharjee, B. Bhattacharya, P. Bianchi, A. Bianchi, L. and Bianchi, N. Bielcik, J. Bielcikova, J. Bilandzic, A. and Biro, G. Biswas, S. Blair, J. T. Blau, D. Blidaru, M. B. and Blume, C. Boca, G. Bock, F. Bogdanov, A. Boi, S. and Bok, J. Boldizsar, L. Bolozdynya, A. Bombara, M. Bond, P. M. Bonomi, G. Borel, H. Borissov, A. Bossi, H. and Botta, E. Bratrud, L. Braun-Munzinger, P. Bregant, M. and Broz, M. Bruno, G. E. Buckland, M. D. Budnikov, D. and Buesching, H. Bufalino, S. Bugnon, O. Buhler, P. Buncic, P. Buthelezi, Z. Butt, J. B. Bysiak, S. A. Caffarri, D. and Caliva, A. Calvo Villar, E. Camacho, J. M. M. Camacho, R. S. Camerini, P. Canedo, F. D. M. Capon, A. A. and Carnesecchi, F. Caron, R. Castillo Castellanos, J. Casula, E. A. R. Catalano, F. Ceballos Sanchez, C. Chakraborty, P. and Chandra, S. Chang, W. Chapeland, S. Chartier, M. and Chattopadhyay, S. Chattopadhyay, S. Chauvin, A. Chavez, T. G. Cheshkov, C. Cheynis, B. Chibante Barroso, V. and Chinellato, D. D. Cho, S. Chochula, P. Christakoglou, P. and Christensen, C. H. Christiansen, P. Chujo, T. Cicalo, C. and Cifarelli, L. Cindolo, F. Ciupek, M. R. Clai, G. and Cleymans, J. Colamaria, F. Colburn, J. S. Colella, D. and Collu, A. Colocci, M. Concas, M. Conesa Balbastre, G. and Conesa del Valle, Z. Contin, G. Contreras, J. G. Cormier, T. M. Cortese, P. Cosentino, M. R. Costa, F. Costanza, S. and Crochet, P. Cuautle, E. Cui, P. Cunqueiro, L. and Dainese, A. Damas, F. P. A. Danisch, M. C. Danu, A. Das, I. Das, P. Das, P. Das, S. Dash, S. De, S. De Caro, A. de Cataldo, G. De Cilladi, L. de Cuveland, J. and De Falco, A. De Gruttola, D. De Marco, N. De Martin, C. and De Pasquale, S. Deb, S. Degenhardt, H. F. Deja, K. R. and Dello Stritto, L. Delsanto, S. Deng, W. Dhankher, P. Di Bari, D. Di Mauro, A. Diaz, R. A. Dietel, T. Ding, Y. and Divia, R. Dixit, D. U. Djuvsland, O. Dmitrieva, U. and Do, J. Dobrin, A. Doenigus, B. Dordic, O. Dubey, A. K. and Dubla, A. Dudi, S. Dukhishyam, M. Dupieux, P. Eder, T. M. Ehlers, R. J. Eikeland, V. N. Elia, D. Erazmus, B. and Ercolessi, F. Erhardt, F. Erokhin, A. Ersdal, M. R. and Espagnon, B. Eulisse, G. Evans, D. Evdokimov, S. and Fabbietti, L. Faggin, M. Faivre, J. Fan, F. Fantoni, A. and Fasel, M. Fecchio, P. Feliciello, A. Feofilov, G. and Fernandez Tellez, A. Ferrero, A. Ferretti, A. Festanti, A. and Feuillard, V. J. G. Figiel, J. Filchagin, S. Finogeev, D. Fionda, F. M. Fiorenza, G. Flor, F. Flores, A. N. and Foertsch, S. Foka, P. Fokin, S. Fragiacomo, E. Fuchs, U. and Funicello, N. Furget, C. Furs, A. Fusco Girard, M. and Gaardhoje, J. J. Gagliardi, M. Gago, A. M. Gal, A. and Galvan, C. D. Ganoti, P. Garabatos, C. Garcia, J. R. A. and Garcia-Solis, E. Garg, K. Gargiulo, C. Garibli, A. and Garner, K. Gasik, P. Gauger, E. F. Gay Ducati, M. B. and Germain, M. Ghosh, J. Ghosh, P. Ghosh, S. K. Giacalone, M. Gianotti, P. Giubellino, P. Giubilato, P. Glaenzer, A. M. C. Glaessel, P. Gonzalez, V. Gonzalez-Trueba, L. H. and Gorbunov, S. Goerlich, L. Gotovac, S. Grabski, V. and Graczykowski, L. K. Graham, K. L. Greiner, L. Grelli, A. and Grigoras, C. Grigoriev, V. Grigoryan, A. Grigoryan, S. and Groettvik, O. S. Grosa, F. Grosse-Oetringhaus, J. F. Grosso, R. Guernane, R. Guilbaud, M. Guittiere, M. Gulbrandsen, K. Gunji, T. Gupta, A. Gupta, R. Guzman, I. B. and Haake, R. Habib, M. K. Hadjidakis, C. Hamagaki, H. and Hamar, G. Hamid, M. Hannigan, R. Haque, M. R. and Harlenderova, A. Harris, J. W. Harton, A. Hasenbichler, J. A. Hassan, H. Hatzifotiadou, D. Hauer, P. Havener, L. B. and Hayashi, S. Heckel, S. T. Hellbaer, E. Helstrup, H. and Herman, T. Hernandez, E. G. Herrera Corral, G. Herrmann, F. and Hetland, K. F. Hillemanns, H. Hills, C. Hippolyte, B. and Hohlweger, B. Honermann, J. Hong, G. H. Horak, D. and Hornung, S. Hosokawa, R. Hristov, P. Huang, C. Hughes, C. Huhn, P. Humanic, T. J. Hushnud, H. Husova, L. A. and Hussain, N. Hutter, D. Iddon, J. P. Ilkaev, R. Ilyas, H. and Inaba, M. Innocenti, G. M. Ippolitov, M. Isakov, A. and Islam, M. S. Ivanov, M. Ivanov, V. Izucheev, V. Jacak, B. Jacazio, N. Jacobs, P. M. Jadlovska, S. Jadlovsky, J. and Jaelani, S. Jahnke, C. Jakubowska, M. J. Janik, M. A. and Janson, T. Jercic, M. Jevons, O. Jin, M. Jonas, F. and Jones, P. G. Jung, J. Jung, M. Junique, A. Jusko, A. and Kalinak, P. Kalweit, A. Kaplin, V. Kar, S. Karasu Uysal, A. Karatovic, D. Karavichev, O. Karavicheva, T. and Karczmarczyk, P. Karpechev, E. Kazantsev, A. Kebschull, U. and Keidel, R. Keil, M. Ketzer, B. Khabanova, Z. Khan, A. M. Khan, S. Khanzadeev, A. Kharlov, Y. Khatun, A. and Khuntia, A. Kileng, B. Kim, B. Kim, D. Kim, D. J. and Kim, E. J. Kim, H. Kim, J. Kim, J. S. Kim, J. Kim, J. Kim, J. Kim, M. Kim, S. Kim, T. Kirsch, S. and Kisel, I. Kiselev, S. Kisiel, A. Klay, J. L. Klein, J. and Klein, S. Klein-Boesing, C. Kleiner, M. Klemenz, T. and Kluge, A. Knospe, A. G. Kobdaj, C. Koehler, M. K. and Kollegger, T. Kondratyev, A. Kondratyeva, N. Kondratyuk, E. and Konig, J. Konigstorfer, S. A. Konopka, P. J. Kornakov, G. Koryciak, S. D. Koska, L. Kovalenko, O. Kovalenko, V. and Kowalski, M. Kralik, I. Kravcakova, A. Kreis, L. and Krivda, M. Krizek, F. Krizkova Gajdosova, K. Kroesen, M. and Krueger, M. Kryshen, E. Krzewicki, M. Kucera, V. Kuhn, C. Kuijer, P. G. Kumaoka, T. Kumar, L. Kundu, S. and Kurashvili, P. Kurepin, A. Kurepin, A. B. Kuryakin, A. and Kushpil, S. Kvapil, J. Kweon, M. J. Kwon, J. Y. Kwon, Y. and La Pointe, S. L. La Rocca, P. Lai, Y. S. Lakrathok, A. and Lamanna, M. Langoy, R. Lapidus, K. Larionov, P. and Laudi, E. Lautner, L. Lavicka, R. Lazareva, T. Lea, R. and Lee, J. Lehrbach, J. Lemmon, R. C. Leon Monzon, I. and Lesser, E. D. Lettrich, M. Levai, P. Li, X. Li, X. L. and Lien, J. Lietava, R. Lim, B. Lim, S. H. and Lindenstruth, V. Lindner, A. Lippmann, C. Liu, A. Liu, J. Lofnes, I. M. Loginov, V. Loizides, C. Loncar, P. and Lopez, J. A. Lopez, X. Lopez Torres, E. Luhder, J. R. and Lunardon, M. Luparello, G. Ma, Y. G. Maevskaya, A. and Mager, M. Mahmood, S. M. Mahmoud, T. Maire, A. Majka, R. D. Malaev, M. Malik, Q. W. Malinina, L. Mal'Kevich, D. and Mallick, N. Malzacher, P. Mandaglio, G. Manko, V. and Manso, F. Manzari, V. Mao, Y. Mares, J. Margagliotti, G. V. Margotti, A. Marin, A. Markert, C. Marquard, M. and Martin, N. A. Martinengo, P. Martinez, J. L. Martinez, M. I. and Martinez Garcia, G. Masciocchi, S. Masera, M. Masoni, A. and Massacrier, L. Mastroserio, A. Mathis, A. M. Matonoha, O. Matuoka, P. F. T. Matyja, A. Mayer, C. Mazuecos, A. L. Mazzaschi, F. Mazzilli, M. Mazzoni, M. A. Mechler, A. F. Meddi, F. Melikyan, Y. Menchaca-Rocha, A. Mengke, C. and Meninno, E. Menon, A. S. Meres, M. Mhlanga, S. and Miake, Y. Micheletti, L. Migliorin, L. C. Mihaylov, D. L. and Mikhaylov, K. Mishra, A. N. Miskowiec, D. Modak, A. and Mohammadi, N. Mohanty, A. P. Mohanty, B. Mohisin Khan, M. and Moravcova, Z. Mordasini, C. Moreira De Godoy, D. A. and Moreno, L. A. P. Morozov, I. Morsch, A. Mrnjavac, T. and Muccifora, V. Mudnic, E. Muehlheim, D. Muhuri, S. and Mulligan, J. D. Mulliri, A. Munhoz, M. G. Munzer, R. H. and Murakami, H. Murray, S. Musa, L. Musinsky, J. Myers, C. J. Myrhca, J. W. Naik, B. Nair, R. Nandi, B. K. and Nania, R. Nappi, E. Naru, M. U. Nassirpour, A. F. and Nattrass, C. Nazarenko, S. Neagu, A. Nellen, L. Nesbo, S. V. Neskovic, G. Nesterov, D. Nielsen, B. S. Nikolaev, S. Nikulin, S. Nikulin, V. Noferini, F. Noh, S. and Nomokonov, P. Norman, J. Novitzky, N. Nowakowski, P. and Nyanin, A. Nystrand, J. Ogino, M. Ohlson, A. Oleniacz, J. Oliveira Da Silva, A. C. Oliver, M. H. Onnerstad, A. and Oppedisano, C. Ortiz Velasquez, A. Osako, T. Oskarsson, A. and Otwinowski, J. Oyama, K. Pachmayer, Y. Padhan, S. and Pagano, D. Paic, G. Palasciano, A. Pan, J. Panebianco, S. Pareek, P. Park, J. Parkkila, J. E. Parmar, S. and Pathak, S. P. Paul, B. Pazzini, J. Pei, H. Peitzmann, T. and Peng, X. Pereira, L. G. Pereira Da Costa, H. Peresunko, D. Perez, G. M. Perrin, S. Pestov, Y. Petracek, V. and Petrovici, M. Pezzi, R. P. Piano, S. Pikna, M. Pillot, P. Pinazza, O. Pinsky, L. Pinto, C. Pisano, S. and Ploskon, M. Planinic, M. Pliquett, F. Poghosyan, M. G. and Polichtchouk, B. Poljak, N. Pop, A. Porteboeuf-Houssais, S. and Porter, J. Pozdniakov, V. Prasad, S. K. Preghenella, R. and Prino, F. Pruneau, C. A. Pshenichnov, I. Puccio, M. and Qiu, S. Quaglia, L. Quishpe, R. E. Ragoni, S. and Rakotozafindrabe, A. Ramello, L. Rami, F. Ramirez, S. A. R. and Ramos, A. G. T. Raniwala, R. Raniwala, S. Raesaenen, S. S. Rath, R. Ravasenga, I. Read, K. F. Redelbach, A. R. and Redlich, K. Rehman, A. Reichelt, P. Reidt, F. and Renfordt, R. Rescakova, Z. Reygers, K. Riabov, A. and Riabov, V. Richert, T. Richter, M. Riedler, P. Riegler, W. Riggi, F. Ristea, C. Rode, S. P. Rodriguez Cahuantzi, M. Roed, K. Rogalev, R. Rogochaya, E. Rogoschinski, T. S. Rohr, D. Roehrich, D. Rojas, P. F. Rokita, P. S. and Ronchetti, F. Rosano, A. Rosas, E. D. Rossi, A. Rotondi, A. Roy, A. Roy, P. Rubini, N. Rueda, O. V. Rui, R. and Rumyantsev, B. Rustamov, A. Ryabinkin, E. Ryabov, Y. and Rybicki, A. Rytkonen, H. Rzesa, W. Saarimaki, O. A. M. and Sadek, R. Sadovsky, S. Saetre, J. Safarik, K. Saha, S. K. Saha, S. Sahoo, B. Sahoo, P. Sahoo, R. Sahoo, S. and Sahu, D. Sahu, P. K. Saini, J. Sakai, S. Sambyal, S. and Samsonov, V. Sarkar, D. Sarkar, N. Sarma, P. Sarti, V. M. Sas, M. H. P. Schambach, J. Scheid, H. S. Schiaua, C. Schicker, R. Schmah, A. Schmidt, C. Schmidt, H. R. and Schmidt, M. O. Schmidt, M. Schmidt, N. V. Schmier, A. R. and Schotter, R. Schukraft, J. Schutz, Y. Schwarz, K. and Schweda, K. Scioli, G. Scomparin, E. Seger, J. E. and Sekiguchi, Y. Sekihata, D. Selyuzhenkov, I. Senyukov, S. and Seo, J. J. Serebryakov, D. Serksnyte, L. Sevcenco, A. and Shabanov, A. Shabetai, A. Shahoyan, R. Shaikh, W. and Shangaraev, A. Sharma, A. Sharma, H. Sharma, M. Sharma, N. Sharma, S. Sheibani, O. Sheikh, A. I. Shigaki, K. and Shimomura, M. Shirinkin, S. Shou, Q. Sibiriak, Y. and Siddhanta, S. Siemiarczuk, T. Silva, T. F. D. Silvermyr, D. and Simatovic, G. Simonetti, G. Singh, B. Singh, R. and Singh, R. Singh, R. Singh, V. K. Singhal, V. Sinha, T. and Sitar, B. Sitta, M. Skaali, T. B. Skorodumovs, G. and Slupecki, M. Smirnov, N. Snellings, R. J. M. Soncco, C. and Song, J. Songmoolnak, A. Soramel, F. Sorensen, S. and Sputowska, I. Stachel, J. Stan, I. Steffanic, P. J. and Stiefelmaier, S. F. Stocco, D. Storetvedt, M. M. and Stylianidis, C. P. Suaide, A. A. P. Sugitate, T. Suire, C. and Suljic, M. Sultanov, R. Sumbera, M. Sumberia, V. and Sumowidagdo, S. Swain, S. Szabo, A. Szarka, I. Tabassam, U. Taghavi, S. F. Taillepied, G. Takahashi, J. Tambave, G. J. Tang, S. Tang, Z. Tarhini, M. Tarzila, M. G. and Tauro, A. Tejeda Munoz, G. Telesca, A. Terlizzi, L. and Terrevoli, C. Tersimonov, G. Thakur, S. Thomas, D. and Tieulent, R. Tikhonov, A. Timmins, A. R. Tkacik, M. and Toia, A. Topilskaya, N. Toppi, M. Torales-Acosta, F. and Torres, S. R. Trifiro, A. Tripathy, S. Tripathy, T. and Trogolo, S. Trombetta, G. Tropp, L. Trubnikov, V. and Trzaska, W. H. Trzcinski, T. P. Trzeciak, B. A. Tumkin, A. and Turrisi, R. Tveter, T. S. Ullaland, K. Umaka, E. N. and Uras, A. Urioni, M. Usai, G. L. Vala, M. Valle, N. and Vallero, S. van der Kolk, N. van Doremalen, L. V. R. van Leeuwen, M. Vande Vyvre, P. Varga, D. Varga, Z. and Varga-Kofarago, M. Vargas, A. Vasileiou, M. Vasiliev, A. and Vazquez Doce, O. Vechernin, V. Vercellin, E. Vergara Limon, S. Vermunt, L. Vertesi, R. Verweij, M. Vickovic, L. and Vilakazi, Z. Villalobos Baillie, O. Vino, G. Vinogradov, A. and Virgili, T. Vislavicius, V. Vodopyanov, A. Volkel, B. and Voelkl, M. A. Voloshin, K. Voloshin, S. A. Volpe, G. and von Haller, B. Vorobyev, I. Voscek, D. Vrlakova, J. and Wagner, B. Weber, M. Wegrzynek, A. Wenzel, S. C. and Wessels, J. P. Wiechula, J. Wikne, J. Wilk, G. and Wilkinson, J. Willems, G. A. Willsher, E. Windelband, B. and Winn, M. Witt, W. E. Wright, J. R. Wu, Y. Xu, R. and Yalcin, S. Yamaguchi, Y. Yamakawa, K. Yang, S. Yano, S. and Yin, Z. Yokoyama, H. Yoo, I. -K. Yoon, J. H. Yuan, S. Yuncu, A. Yurchenko, V. Zaccolo, V. Zaman, A. and Zampolli, C. Zanoli, H. J. C. Zardoshti, N. Zarochentsev, A. and Zavada, P. Zaviyalov, N. Zbroszczyk, H. Zhalov, M. and Zhang, S. Zhang, X. Zhang, Y. Zherebchevskii, V. Zhi, Y. and Zhou, D. Zhou, Y. Zhu, J. Zhu, Y. Zichichi, A. and Zinovjev, G. Zurlo, N.

Subjects
Nuclear Experiment
Abstract

Two-particle angular correlations are measured in high-multiplicity proton-proton collisions at = 13 TeV by the ALICE Collaboration. The yields of particle pairs at short-(eta similar to 0) and long-range (1.6 < || < 1.8) in pseudorapidity are extracted on the near-side ( 0). They are reported as a function of transverse momentum (p(T)) in the range 1 < p(T)< 4 GeV/c. Furthermore, the event-scale dependence is studied for the first time by requiring the presence of high-p(T) leading particles or jets for varying p(T) thresholds. The results demonstrate that the long-range “ridge” yield, possibly related to the collective behavior of the system, is present in events with high-p(T) processes as well. The magnitudes of the short- and long-range yields are found to grow with the event scale. The results are compared to EPOS LHC and PYTHIA 8 calculations, with and without string-shoving interactions. It is found that while both models describe the qualitative trends in the data, calculations from EPOS LHC show a better quantitative agreement for the p(T) dependency, while overestimating the event-scale dependency.

Published
2021

5. Kaon-proton strong interaction at low relative momentum via femtoscopy in Pb-Pb collisions at the LHC

Author

Acharya, S. Adamova, D. Adler, A. Adolfsson, J. Rinella, G. Aglieri Agnello, M. Agrawal, N. Ahammed, Z. Ahmad, S. and Ahn, S. U. Ahuja, I Akbar, Z. Akindinov, A. and Al-Turany, M. Alam, S. N. Aleksandrov, D. Alessandro, B. and Alfanda, H. M. Alfaro Molina, R. Ali, B. Ali, Y. Alici, A. Alizadehvandchali, N. Alkin, A. Alme, J. Alt, T. and Altenkamper, L. Altsybeev, I Anaam, M. N. Andrei, C. and Andreou, D. Andronic, A. Angeletti, M. Anguelov, V and Antinori, F. Antonioli, P. Anuj, C. Apadula, N. and Aphecetche, L. Appelshaeuser, H. Arcelli, S. Arnaldi, R. and Arsene, I. C. Arslandok, M. Augustinus, A. Averbeck, R. and Aziz, S. Azmi, M. D. Badala, A. Baek, Y. W. Bai, X. and Bailhache, R. Bailung, Y. Bala, R. Balbino, A. and Baldisseri, A. Balis, B. Ball, M. Banerjee, D. Barbera, R. Barioglio, L. Barlou, M. Barnafoldi, G. G. Barnby, L. S. Barret, V Bartels, C. Barth, K. Bartsch, E. and Baruffaldi, F. Bastid, N. Basu, S. Batigne, G. Batyunya, B. Bauri, D. Bazo Alba, J. L. Bearden, I. G. Beattie, C. and Belikov, I Hechavarria, A. D. C. Bell Bellini, F. and Bellwied, R. Belokurova, S. Belyaev, V Bencedi, G. and Beole, S. Bercuci, A. Berdnikov, Y. Berdnikova, A. and Berenyi, D. Bergmann, L. Besoiu, M. G. Betev, L. and Bhaduri, P. P. Bhasin, A. Bhat, I. R. Bhat, M. A. and Bhattacharjee, B. Bhattacharya, P. Bianchi, L. Bianchi, N. and Bielcik, J. Bielcikova, J. Biernat, J. Bilandzic, A. and Biro, G. Biswas, S. Blair, J. T. Blau, D. Blidaru, M. B. and Blume, C. Boca, G. Bock, F. Bogdanov, A. Boi, S. and Bok, J. Boldizsar, L. Bolozdynya, A. Bombara, M. Bond, P. M. Bonomi, G. Borel, H. Borissov, A. Bossi, H. and Botta, E. Bratrud, L. Braun-Munzinger, P. Bregant, M. and Broz, M. Bruno, G. E. Buckland, M. D. Budnikov, D. and Buesching, H. Bufalino, S. Bugnon, O. Buhler, P. and Buthelezi, Z. Butt, J. B. Bysiak, S. A. Caffarri, D. and Cai, M. Caines, H. Caliva, A. Calvo Villar, E. Camacho, J. M. M. Camacho, R. S. Camerini, P. Canedo, F. D. M. and Carnesecchi, F. Caron, R. Castellanos, J. Castillo Casula, E. A. R. Catalano, F. Ceballos Sanchez, C. Chakraborty, P. and Chandra, S. Chapeland, S. Chartier, M. Chattopadhyay, S. and Chattopadhyay, S. Chauvin, A. Chavez, T. G. Cheshkov, C. and Cheynis, B. Barroso, V. Chibante Chinellato, D. D. Cho, S. Chochula, P. Christakoglou, P. Christensen, C. H. and Christiansen, P. Chujo, T. Cicalo, C. Cifarelli, L. and Cindolo, F. Ciupek, M. R. Clai, G. Cleymans, J. and Colamaria, F. Colburn, J. S. Colella, D. Collu, A. and Colocci, M. Concas, M. Balbastre, G. Conesa del Valle, Z. Conesa Contin, G. Contreras, J. G. Coquet, M. L. and Cormier, T. M. Cortese, P. Cosentino, M. R. Costa, F. and Costanza, S. Crochet, P. Cuautle, E. Cui, P. Cunqueiro, L. Dainese, A. Damas, F. P. A. Danisch, M. C. Danu, A. and Das, I Das, P. Das, P. Das, S. Dash, S. De, S. and De Caro, A. de Cataldo, G. De Cilladi, L. de Cuveland, J. De Falco, A. De Gruttola, D. De Marco, N. De Martin, C. De Pasquale, S. Deb, S. Degenhardt, H. F. Deja, K. R. and Dello Stritto, L. Delsanto, S. Deng, W. Dhankher, P. and Di Bari, D. Di Mauro, A. Diaz, R. A. Dietel, T. Ding, Y. and Divia, R. Djuvsland, O. Dixit, D. U. Dmitrieva, U. and Do, J. Dobrin, A. Donigus, B. Dordic, O. Dubey, A. K. and Dubla, A. Dudi, S. Dukhishyam, M. Dupieux, P. and Dzalaiova, N. Eder, T. M. Ehlers, R. J. Eikeland, V. N. and Elia, D. Erazmus, B. Ercolessi, F. Erhardt, F. Erokhin, A. Ersdal, M. R. Espagnon, B. Eulisse, G. Evans, D. and Evdokimov, S. Fabbietti, L. Faggin, M. Faivre, J. Fan, F. Fantoni, A. Fasel, M. Fecchio, P. Feliciello, A. and Feofilov, G. Fernandez Tellez, A. Ferrero, A. Ferretti, A. and Feuillard, V. J. G. Figiel, J. Filchagin, S. Finogeev, D. Fionda, F. M. Fiorenza, G. Flor, F. Flores, A. N. and Foertsch, S. Foka, P. Fokin, S. Fragiacomo, E. Frajna, E. Fuchs, U. Funicello, N. Furget, C. Furs, A. and Gaardhoje, J. J. Gagliardi, M. Gago, A. M. Gal, A. and Galvan, C. D. Ganoti, P. Garabatos, C. Garcia, J. R. A. and Garcia-Solis, E. Garg, K. Gargiulo, C. Garibli, A. and Garner, K. Gasik, P. Gauger, E. F. Gautam, A. Gay Ducati, M. B. Germain, M. Ghosh, J. Ghosh, P. Ghosh, S. K. Giacalone, M. Gianotti, P. Giubellino, P. Giubilato, P. Glaenzer, A. M. C. Glassel, P. Goh, D. J. Q. and Gonzalez, V Gonzalez-Trueba, L. H. Gorbunov, S. Gorgon, M. and Gorlich, L. Gotovac, S. Grabski, V Graczykowski, L. K. and Greiner, L. Grelli, A. Grigoras, C. Grigoriev, V and Grigoryan, A. Grigoryan, S. Groettvik, O. S. Grosa, F. and Grosse-Oetringhaus, J. F. Grosso, R. Guardiano, G. G. and Guernane, R. Guilbaud, M. Gulbrandsen, K. Gunji, T. and Gupta, A. Gupta, R. Guzman, I. B. Guzman, S. P. Gyulai, L. Habib, M. K. Hadjidakis, C. Halimoglu, G. Hamagaki, H. Hamar, G. Hamid, M. Hannigan, R. Haque, M. R. and Harlenderova, A. Harris, J. W. Harton, A. Hasenbichler, J. A. Hassan, H. Hatzifotiadou, D. Hauer, P. Havener, L. B. and Hayashi, S. Heckel, S. T. Hellbar, E. Helstrup, H. and Herman, T. Hernandez, E. G. Herrera Corral, G. Herrmann, F. and Hetland, K. F. Hillemanns, H. Hills, C. Hippolyte, B. and Hofman, B. Hohlweger, B. Honermann, J. Hong, G. H. and Horak, D. Hornung, S. Horzyk, A. Hosokawa, R. Hristov, P. Huang, C. Hughes, C. Huhn, P. Humanic, T. J. and Hushnud, H. Husova, L. A. Hutson, A. Hutter, D. Iddon, J. P. Ilkaev, R. Ilyas, H. Inaba, M. Innocenti, G. M. and Ippolitov, M. Isakov, A. Islam, M. S. Ivanov, M. and Ivanov, V Izucheev, V Jablonski, M. Jacak, B. Jacazio, N. Jacobs, P. M. Jadlovska, S. Jadlovsky, J. Jaelani, S. and Jahnke, C. Jakubowska, M. J. Janik, M. A. Janson, T. and Jercic, M. Jevons, O. Jonas, F. Jones, P. G. Jowett, J. M. Jung, J. Jung, M. Junique, A. Jusko, A. Kaewjai, J. Kalinak, P. Kalweit, A. Kaplin, V Kar, S. Uysal, A. Karasu Karatovic, D. Karavichev, O. Karavicheva, T. and Karczmarczyk, P. Karpechev, E. Kazantsev, A. Kebschull, U. and Keidel, R. Keijdener, D. L. D. Keil, M. Ketzer, B. and Khabanova, Z. Khan, A. M. Khan, S. Khanzadeev, A. and Kharlov, Y. Khatun, A. Khuntia, A. Kileng, B. Kim, B. and Kim, D. Kim, D. J. Kim, E. J. Kim, J. Kim, J. S. and Kim, J. Kim, J. Kim, J. Kim, M. Kim, S. Kim, T. and Kirsch, S. Kisel, I Kiselev, S. Kisiel, A. Kitowski, J. P. Klay, J. L. Klein, J. Klein, S. Klein-Bosing, C. and Kleiner, M. Klemenz, T. Kluge, A. Knospe, A. G. Kobdaj, C. Kohler, M. K. Kollegger, T. Kondratyev, A. and Kondratyeva, N. Kondratyuk, E. Konig, J. Konigstorfer, S. A. and Konopka, P. J. Kornakov, G. Koryciak, S. D. Koska, L. and Kotliarov, A. Kovalenko, O. Kovalenko, V Kowalski, M. and Kralik, I Kravcakova, A. Kreis, L. Krivda, M. and Krizek, F. Gajdosova, K. Krizkova Kroesen, M. Krueger, M. and Kryshen, E. Krzewicki, M. Kuhn, C. Kuijer, P. G. and Kumaoka, T. Kumar, D. Kumar, L. Kumar, N. Kundu, S. and Kurashvili, P. Kurepin, A. Kurepin, A. B. Kuryakin, A. and Kushpil, S. Kvapil, J. Kweon, M. J. Kwon, J. Y. Kwon, Y. and La Pointe, S. L. La Rocca, P. Lai, Y. S. Lakrathok, A. and Lamanna, M. Langoy, R. Lapidus, K. Larionov, P. and Laudi, E. Lautner, L. Lavicka, R. Lazareva, T. Lea, R. and Lee, J. Lehrbach, J. Lemmon, R. C. Leon Monzon, I and Lesser, E. D. Lettrich, M. Levai, P. Li, X. Li, X. L. and Lien, J. Lietava, R. Lim, B. Lim, S. H. and Lindenstruth, V Lindner, A. Lippmann, C. Liu, A. Liu, J. and Lofnes, I. M. Loginov, V Loizides, C. Loncar, P. and Lopez, J. A. Lopez, X. Lopez Torres, E. Luhder, J. R. and Lunardon, M. Luparello, G. Ma, Y. G. Maevskaya, A. and Mager, M. Mahmoud, T. Maire, A. Malaev, M. Malik, Q. W. and Malinina, L. Mal'Kevich, D. Mallick, N. Malzacher, P. and Mandaglio, G. Manko, V Manso, F. Manzari, V Mao, Y. and Mares, J. Margagliotti, V, G. Margotti, A. Marin, A. and Markert, C. Marquard, M. Martin, N. A. Martinengo, P. and Martinez, J. L. Martinez, I, M. Garcia, G. Martinez and Masciocchi, S. Masera, M. Masoni, A. Massacrier, L. and Mastroserio, A. Mathis, A. M. Matonoha, O. Matuoka, P. F. T. and Matyja, A. Mayer, C. Mazuecos, A. L. Mazzaschi, F. and Mazzilli, M. Mazzoni, M. A. Mdhluli, J. E. Mechler, A. F. and Meddi, F. Melikyan, Y. Menchaca-Rocha, A. Meninno, E. and Menon, A. S. Meres, M. Mhlanga, S. Miake, Y. and Micheletti, L. Migliorin, L. C. Mihaylov, D. L. Mikhaylov, K. Mishra, A. N. Modak, A. Mohanty, A. P. Mohanty, B. and Khan, M. Mohisin Moravcova, Z. Mordasini, C. De Godoy, D. A. Moreira Moreno, L. A. P. Morozov, I Morsch, A. and Mrnjavac, T. Muccifora, V Mudnic, E. Muehlheim, D. and Muhuri, S. Mulligan, J. D. Mulliri, A. Munhoz, M. G. and Munzer, R. H. Murakami, H. Murray, S. Musa, L. Musinsky, J. Myers, C. J. Myrcha, J. W. Naik, B. Nair, R. and Nandi, B. K. Nania, R. Nappi, E. Naru, M. U. Nassirpour, A. F. Nath, A. Nattrass, C. Neagu, A. Nellen, L. and Nesbo, V, S. Neskovic, G. Nesterov, D. Nielsen, B. S. and Nikolaev, S. Nikulin, S. Nikulin, V Noferini, F. Noh, S. and Nomokonov, P. Norman, J. Novitzky, N. Nowakowski, P. and Nyanin, A. Nystrand, J. Ogino, M. Ohlson, A. Okorokov, V. A. Oleniacz, J. Da Silva, A. C. Oliveira Oliver, M. H. and Onnerstad, A. Oppedisano, C. Ortiz Velasquez, A. Osako, T. Oskarsson, A. Otwinowski, J. Oyama, K. Pachmayer, Y. and Padhan, S. Pagano, D. Paic, G. Palasciano, A. Pan, J. Panebianco, S. Pareek, P. Park, J. Parkkila, J. E. and Pathak, S. P. Patra, R. N. Paul, B. Pazzini, J. Pei, H. Peitzmann, T. Peng, X. Pereira, L. G. Da Costa, H. Pereira Peresunko, D. Perez, G. M. Perrin, S. Pestov, Y. and Petracek, V Petrovici, M. Pezzi, R. P. Piano, S. and Pikna, M. Pillot, P. Pinazza, O. Pinsky, L. Pinto, C. and Pisano, S. Planinic, M. Pliquett, F. Poghosyan, M. G. and Polichtchouk, B. Politano, S. Poljak, N. Pop, A. and Porteboeuf-Houssais, S. Porter, J. Pozdniakov, V Prasad, S. K. Preghenella, R. Prino, F. Pruneau, C. A. Pshenichnov, I Puccio, M. Qiu, S. Quaglia, L. Quishpe, R. E. and Ragoni, S. Rakotozafindrabe, A. Ramello, L. Rami, F. and Ramirez, S. A. R. Ramos, A. G. T. Rancien, T. A. Raniwala, R. Raniwala, S. Rasanen, S. S. Rath, R. Ravasenga, I and Read, K. F. Redelbach, A. R. Redlich, K. Rehman, A. and Reichelt, P. Reidt, F. Reme-ness, H. A. Renfordt, R. and Rescakova, Z. Reygers, K. Riabov, A. Riabov, V Richert, T. Richter, M. Riegler, W. Riggi, F. Ristea, C. and Rode, S. P. Rodriguez Cahuantzi, M. Roed, K. Rogalev, R. and Rogochaya, E. Rogoschinski, T. S. Rohr, D. Roherich, D. and Rojas, P. F. Rokita, P. S. Ronchetti, F. Rosano, A. and Rosas, E. D. Rossi, A. Rotondi, A. Roy, A. Roy, P. and Roy, S. Rubini, N. Rueda, V, O. Rui, R. Rumyantsev, B. and Russek, P. G. Rustamov, A. Ryabinkin, E. Ryabov, Y. and Rybicki, A. Rytkonen, H. Rzesa, W. Saarimaki, O. A. M. and Sadek, R. Sadovsky, S. Saetre, J. Safarik, K. Saha, S. K. Saha, S. Sahoo, B. Sahoo, P. Sahoo, R. Sahoo, S. and Sahu, D. Sahu, P. K. Saini, J. Sakai, S. Sambyal, S. and Samsonov, V Sarkar, D. Sarkar, N. Sarma, P. Sarti, V. M. Sas, M. H. P. Schambach, J. Scheid, H. S. Schiaua, C. Schicker, R. Schmah, A. Schmidt, C. Schmidt, H. R. and Schmidt, M. O. Schmidt, M. Schmidt, V, N. Schmier, A. R. and Schotter, R. Schukraft, J. Schutz, Y. Schwarz, K. and Schweda, K. Scioli, G. Scomparin, E. Seger, J. E. and Sekiguchi, Y. Sekihata, D. Selyuzhenkov, I Senyukov, S. and Seo, J. J. Serebryakov, D. Sevcenco, A. Shaba, T. J. and Shabanov, A. Shabetai, A. Shahoyan, R. Shaikh, W. and Shangaraev, A. Sharma, A. Sharma, H. Sharma, M. Sharma, N. Sharma, S. Sheibani, O. Shigaki, K. Shimomura, M. and Shirinkin, S. Shou, Q. Sibiriak, Y. Siddhanta, S. and Siemiarczuk, T. Silva, T. F. Silvermyr, D. Simonetti, G. and Singh, B. Singh, R. Singh, R. Singh, R. Singh, V. K. and Singhal, V Sinha, T. Sitar, B. Sitta, M. Skaali, T. B. and Skorodumovs, G. Slupecki, M. Smirnov, N. Snellings, R. J. M. Soncco, C. Song, J. Songmoolnak, A. Soramel, F. and Sorensen, S. Sputowska, I Stachel, J. Stan, I and Steffanic, P. J. Stiefelmaier, S. F. Stocco, D. Storehaug, I and Storetvedt, M. M. Stylianidis, C. P. Suaide, A. A. P. and Sugitate, T. Suire, C. Suljic, M. Sultanov, R. Sumbera, M. Sumberia, V Sumowidagdo, S. Swain, S. Szabo, A. and Szarka, I Tabassam, U. Taghavi, S. F. Taillepied, G. and Takahashi, J. Tambave, G. J. Tang, S. Tang, Z. Tarhini, M. Tarzila, M. G. Tauro, A. Tejeda Munoz, G. Telesca, A. and Terlizzi, L. Terrevoli, C. Tersimonov, G. Thakur, S. and Thomas, D. Tieulent, R. Tikhonov, A. Timmins, A. R. and Tkacik, M. Toia, A. Topilskaya, N. Toppi, M. and Torales-Acosta, F. Tork, T. Torres, R. C. Torres, S. R. and Trifiro, A. Tripathy, S. Tripathy, T. Trogolo, S. and Trombetta, G. Trubnikov, V Trzaska, W. H. Trzcinski, T. P. and Trzeciak, B. A. Tumkin, A. Turrisi, R. Tveter, T. S. and Ullaland, K. Uras, A. Urioni, M. Usai, G. L. Vala, M. and Valle, N. Vallero, S. van der Kolk, N. van Doremalen, L. V. R. van Leeuwen, M. Vande Vyvre, P. Varga, D. Varga, Z. Varga-Kofarago, M. Vargas, A. Vasileiou, M. Vasiliev, A. Doce, O. Vazquez Vechernin, V. Vercellin, E. Vergara Limon, S. Vermunt, L. Vertesi, R. Verweij, M. Vickovic, L. Vilakazi, Z. Baillie, O. Villalobos Vino, G. and Vinogradov, A. Virgili, T. Vislavicius, V. Vodopyanov, A. and Volkel, B. Voelkl, M. A. Voloshin, K. Voloshin, S. A. and Volpe, G. von Haller, B. Vorobyev, I Voscek, D. and Vozniuk, N. Vrlakova, J. Wagner, B. Wang, C. Wang, D. and Weber, M. Weelden, V, R. J. G. Wegrzynek, A. Wenzel, S. C. Wessels, J. P. Wiechula, J. Wikne, J. Wilk, G. and Wilkinson, J. Willems, G. A. Windelband, B. Winn, M. and Witt, W. E. Wright, J. R. Wu, W. Wu, Y. Xu, R. and Yalcin, S. Yamaguchi, Y. Yamakawa, K. Yang, S. Yano, S. and Yin, Z. Yokoyama, H. Yoo, I-K Yoon, J. H. Yuan, S. and Yuncu, A. Zaccolo, V Zaman, A. Zampolli, C. Zanoli, H. J. C. Zardoshti, N. Zarochentsev, A. Zavada, P. and Zaviyalov, N. Zbroszczyk, H. Zhalov, M. Zhang, S. Zhang, X. Zhang, Y. Zherebchevskii, V Zhi, Y. Zhou, D. and Zhou, Y. Zhu, J. Zhu, Y. Zichichi, A. Zinovjev, G. and Zurlo, N. ALICE Collaboration

Subjects
High Energy Physics::Experiment, Nuclear Experiment
Abstract

In quantum scattering processes between two particles, aspects characterizing the strong and Coulomb forces can be observed in kinematic distributions of the particle pairs. The sensitivity to the interaction potential reaches a maximum at low relative momentum and vanishing distance between the two particles. Ultrarelativistic heavy-ion collisions at the LHC provide an abundant source of many hadron species and can be employed as a measurement method of scattering parameters that is complementary to scattering experiments. This study confirms that momentum correlations of particles produced in Pb-Pb collisions at the LHC provide an accurate measurement of kaon-proton scattering parameters at low relative momentum, allowing precise access to the K- p -> K- p process. This work also validates the femtoscopic measurement in ultrarelativistic heavy-ion collisions as an alternative to scattering experiments and a complementary tool to the study of exotic atoms with comparable precision. In this work, the first femtoscopic measurement of momentum correlations of K- p (K+(p) over bar) and K+p (K-(p) over bar) pairs in Pb-Pb collisions at centre-of-mass energy per nucleon pair of root sNN = 5.02 TeV registered by the ALICE experiment is reported. The components of the K- p complex scattering length are extracted and found to be Rf(0) = -0.91 +/- 0.03(stat)(-0.03)(+0.17) (syst) and Sf(0) = 0.92 +/- 0.05(stat)(-0.33)(+0.12)(syst). The results are compared with chiral effective field theory predictions as well as with existing data from dedicated scattering and exotic kaonic atom experiments. (C) 2021 ALICE, European Organization for Nuclear Research. Published by Elsevier B.V.

Published
2021

6. Measurements of mixed harmonic cumulants in Pb-Pb collisions at root s(NN)=5.02 TeV

Author

Acharya, S. Adamova, D. Adler, A. Adolfsson, J. Rinella, G. Aglieri Agnello, M. Agrawal, N. Ahammed, Z. Ahmad, S. and Ahn, S. U. Akbar, Z. Akindinov, A. Al-Turany, M. and Aleksandrov, D. Alessandro, B. Alfanda, H. M. Alfaro Molina, R. Ali, B. Ali, Y. Alici, A. Alizadehvandchali, N. and Alkin, A. Alme, J. Alt, T. Altenkamper, L. Altsybeev, I and Anaam, M. N. Andrei, C. Andreou, D. Andronic, A. and Anguelov, V Antinori, F. Antonioli, P. Anuj, C. Apadula, N. Aphecetche, L. Appelshaeuser, H. Arcelli, S. Arnaldi, R. Arsene, I. C. Arslandok, M. Augustinus, A. Averbeck, R. Aziz, S. Azmi, M. D. Badala, A. Baek, Y. W. Bai, X. Bailhache, R. Bailung, Y. Bala, R. Balbino, A. and Baldisseri, A. Ball, M. Banerjee, D. Barbera, R. and Barioglio, L. Barlou, M. Barnafoldi, G. G. Barnby, L. S. and Barret, V Bartels, C. Barth, K. Bartsch, E. Baruffaldi, F. Bastid, N. Basu, S. Batigne, G. Batyunya, B. and Bauri, D. Bazo Alba, J. L. Bearden, I. G. Beattie, C. and Belikov, I Hechavarria, A. D. C. Bell Bellini, F. Bellwied, R. Belokurova, S. Belyaev, V Bencedi, G. Beole, S. and Bercuci, A. Berdnikov, Y. Berdnikova, A. Berenyi, D. and Bergmann, L. Besoiu, M. G. Betev, L. Bhaduri, P. P. and Bhasin, A. Bhat, I. R. Bhat, M. A. Bhattacharjee, B. and Bhattacharya, P. Bianchi, L. Bianchi, N. Bielcik, J. and Bielcikova, J. Biernat, J. Bilandzic, A. Biro, G. and Biswas, S. Blair, J. T. Blau, D. Blidaru, M. B. Blume, C. Boca, G. Bock, F. Bogdanov, A. Boi, S. Bok, J. and Boldizsar, L. Bolozdynya, A. Bombara, M. Bond, P. M. and Bonomi, G. Borel, H. Borissov, A. Bossi, H. Botta, E. and Bratrud, L. Braun-Munzinger, P. Bregant, M. Broz, M. and Bruno, G. E. Buckland, M. D. Budnikov, D. Buesching, H. and Bufalino, S. Bugnon, O. Buhler, P. Buthelezi, Z. Butt, J. B. Bysiak, S. A. Caffarri, D. Cai, M. Caliva, A. and Calvo Villar, E. Camacho, J. M. M. Camacho, R. S. Camerini, P. Canedo, F. D. M. Capon, A. A. Carnesecchi, F. Caron, R. Castellanos, J. Castillo Casula, E. A. R. 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Yalcin, S. Yamaguchi, Y. and Yamakawa, K. Yang, S. Yano, S. Yin, Z. Yokoyama, H. and Yoo, I-K Yoon, J. H. Yuan, S. Yuncu, A. Zaccolo, V and Zaman, A. Zampolli, C. Zanoli, H. J. C. Zardoshti, N. and Zarochentsev, A. Zavada, P. Zaviyalov, N. Zbroszczyk, H. and Zhalov, M. Zhang, S. Zhang, X. Zhang, Y. and Zherebchevskii, V Zhi, Y. Zhou, D. Zhou, Y. Zhu, J. and Zhu, Y. Zichichi, A. Zinovjev, G. Zurlo, N. ALICE Collaboration

Abstract

Correlations between moments of different flow coefficients are measured in Pb-Pb collisions at root s(NN) = 5.02 TeV recorded with the ALICE detector. These new measurements are based on multiparticle mixed harmonic cumulants calculated using charged particles in the pseudorapidity region vertical bar eta vertical bar < 0.8 with the transverse momentum range 0.2 < p(T) < 5.0 GeV/c. The centrality dependence of correlations between two flow coefficients as well as the correlations between three flow coefficients, both in terms of their second moments, are shown. In addition, a collection of mixed harmonic cumulants involving higher moments of v(2) and v(3) is measured for the first time, where the characteristic signature of negative, positive and negative signs of four-, six- and eight-particle cumulants are observed, respectively. The measurements are compared to the hydrodynamic calculations using iEBE-VISHNU with AMPT and TRENTo initial conditions. It is shown that the measurements carried out using the LHC Run 2 data in 2015 have the precision to explore the details of initial-state fluctuations and probe the nonlinear hydrodynamic response of v(2) and v(3) to their corresponding initial anisotropy coefficients epsilon(2) and epsilon(3). These new studies on correlations between three flow coefficients as well as correlations between higher moments of two different flow coefficients will pave the way to tighten constraints on initial-state models and help to extract precise information on the dynamic evolution of the hot and dense matter created in heavy-ion collisions at the LHC. (C) 2021 The Author. Published by Elsevier B.V.

Published
2021

7. Measurement of the Cross Sections of Xi(0)(c) and Xi(+)(c) Baryons and of the Branching-Fraction Ratio BRo (Xi(0)(c) -> Xi(-) e(+) nu(e))/BR(Xi(0)(c) -> Xi(-) pi(+)) in pp Collisions at root s=13 TeV

Author

Acharya, S. Adamova, D. Adler, A. Adolfsson, J. Rinella, G. Aglieri Agnello, M. Agrawal, N. Ahammed, Z. Ahmad, S. and Ahn, S. U. Ahuja, I. Akbar, Z. Akindinov, A. and Al-Turany, M. Alam, S. N. Aleksandrov, D. Alessandro, B. and Alfanda, H. M. Molina, R. Alfaro Ali, B. Ali, Y. Alici, A. Alizadehvandchali, N. Alkin, A. Alme, J. Alt, T. and Altenkamper, L. Altsybeev, I. Anaam, M. N. Andrei, C. and Andreou, D. Andronic, A. Angeletti, M. Anguelov, V. and Antinori, F. Antonioli, P. Anuj, C. Apadula, N. and Aphecetche, L. Appelshauser, H. Arcelli, S. Arnaldi, R. and Arsene, I. C. Arslandok, M. Augustinus, A. Averbeck, R. and Aziz, S. Azmi, M. D. Badala, A. Baek, Y. W. Bai, X. and Bailhache, R. Bailung, Y. Bala, R. Balbino, A. and Baldisseri, A. Balis, B. Ball, M. Banerjee, D. Barbera, R. Barioglio, L. Barlou, M. Barnafoldi, G. G. Barnby, L. S. Barret, V. Bartels, C. Barth, K. Bartsch, E. and Baruffaldi, F. Bastid, N. Basu, S. Batigne, G. Batyunya, B. Bauri, D. Alba, J. L. Bazo Bearden, I. G. Beattie, C. and Belikov, I. Hechavarria, A. D. C. Bell Bellini, F. and Bellwied, R. Belokurova, S. Belyaev, V. Bencedi, G. and Beole, S. Bercuci, A. Berdnikov, Y. Berdnikova, A. and Berenyi, D. Bergmann, L. Besoiu, M. G. Betev, L. and Bhaduri, P. P. Bhasin, A. Bhat, I. R. Bhat, M. A. and Bhattacharjee, B. Bhattacharya, P. Bianchi, L. Bianchi, N. and Bielcik, J. Bielcikova, J. Biernat, J. Bilandzic, A. and Biro, G. Biswas, S. Blair, J. T. Blau, D. Blidaru, M. B. and Blume, C. Boca, G. Bock, F. Bogdanov, A. Boi, S. and Bok, J. Boldizsar, L. Bolozdynya, A. Bombara, M. Bond, P. M. Bonomi, G. Borel, H. Borissov, A. Bossi, H. and Botta, E. Bratrud, L. Braun-Munzinger, P. Bregant, M. and Broz, M. Bruno, G. E. Buckland, M. D. Budnikov, D. and Buesching, H. Bufalino, S. Bugnon, O. Buhler, P. and Buthelezi, Z. Butt, J. B. Bysiak, S. A. Caffarri, D. and Cai, M. Caines, H. Caliva, A. Villar, E. Calvo Camacho, J. M. M. Camacho, R. S. Camerini, P. Canedo, F. D. M. and Carnesecchi, F. Caron, R. Castellanos, J. Castillo Casula, E. A. R. Catalano, F. Sanchez, C. Ceballos Chakraborty, P. and Chandra, S. Chapeland, S. Chartier, M. Chattopadhyay, S. and Chattopadhyay, S. Chauvin, A. Chavez, T. G. Cheshkov, C. and Cheynis, B. Barroso, V. Chibante Chinellato, D. D. Cho, S. Chochula, P. Christakoglou, P. Christensen, C. H. and Christiansen, P. Chujo, T. Cicalo, C. Cifarelli, L. and Cindolo, F. Ciupek, M. R. Clai, G. Cleymans, J. and Colamaria, F. Colburn, J. S. Colella, D. Collu, A. and Colocci, M. Concas, M. Balbastre, G. Conesa del Valle, Z. Conesa Contin, G. Contreras, J. G. Coquet, M. L. and Cormier, T. M. Cortese, P. Cosentino, M. R. Costa, F. and Costanza, S. Crochet, P. Cruz-Torres, R. Cuautle, E. and Cui, P. Cunqueiro, L. Dainese, A. Damas, F. P. A. and Danisch, M. C. Danu, A. Das, I. Das, P. Das, P. Das, S. Dash, S. De, S. De Caro, A. de Cataldo, G. De Cilladi, L. de Cuveland, J. De Falco, A. De Gruttola, D. and De Marco, N. De Martin, C. De Pasquale, S. Deb, S. and Degenhardt, H. F. Deja, K. R. Dello Stritto, L. Delsanto, S. and Deng, W. Dhankher, P. Di Bari, D. Di Mauro, A. Diaz, R. A. Dietel, T. Ding, Y. Divia, R. Dixit, D. U. and Djuvsland, O. Dmitrieva, U. Do, J. Dobrin, A. Donigus, B. Dordic, O. Dubey, A. K. Dubla, A. Dudi, S. and Dukhishyam, M. Dupieux, P. Dzalaiova, N. Eder, T. M. and Ehlers, R. J. Eikeland, V. N. Elia, D. Erazmus, B. and Ercolessi, F. Erhardt, F. Erokhin, A. Ersdal, M. R. and Espagnon, B. Eulisse, G. Evans, D. Evdokimov, S. and Fabbietti, L. Faggin, M. Faivre, J. Fan, F. Fantoni, A. and Fasel, M. Fecchio, P. Feliciello, A. Feofilov, G. and Tellez, A. Fernandez Ferrero, A. Ferretti, A. Feuillard, V. J. G. Figiel, J. Filchagin, S. Finogeev, D. Fionda, F. M. Fiorenza, G. Flor, F. Flores, A. N. Foertsch, S. and Foka, P. Fokin, S. Fragiacomo, E. Frajna, E. Fuchs, U. and Funicello, N. Furget, C. Furs, A. Gaardhoje, J. J. and Gagliardi, M. Gago, A. M. Gal, A. Galvan, C. D. Ganoti, P. Garabatos, C. Garcia, J. R. A. 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Langoy, R. Lapidus, K. and Larionov, P. Laudi, E. Lautner, L. Lavicka, R. Lazareva, T. Lea, R. Lee, J. Lehrbach, J. Lemmon, R. C. and Monzon, I. Leon Lesser, E. D. Lettrich, M. Levai, P. Li, X. Li, X. L. Lien, J. Lietava, R. Lim, B. Lim, S. H. and Lindenstruth, V. Lindner, A. Lippmann, C. Liu, A. and Liu, J. Lofnes, I. M. Loginov, V. Loizides, C. Loncar, P. Lopez, J. A. Lopez, X. Torres, E. Lopez Luhder, J. R. and Lunardon, M. Luparello, G. Ma, Y. G. Maevskaya, A. and Mager, M. Mahmoud, T. Maire, A. Malaev, M. Malik, Q. W. and Malinina, L. Mal'Kevich, D. Mallick, N. Malzacher, P. and Mandaglio, G. Manko, V. Manso, F. Manzari, V. Mao, Y. Mares, J. Margagliotti, G. V. Margotti, A. Marin, A. and Markert, C. Marquard, M. Martin, N. A. Martinengo, P. and Martinez, J. L. Martinez, M. I. Garcia, G. Martinez and Masciocchi, S. Masera, M. Masoni, A. Massacrier, L. and Mastroserio, A. Mathis, A. M. Matonoha, O. Matuoka, P. F. T. and Matyja, A. Mayer, C. Mazuecos, A. L. Mazzaschi, F. and Mazzilli, M. Mazzoni, M. A. Mdhluli, J. E. Mechler, A. F. and Meddi, F. Melikyan, Y. Menchaca-Rocha, A. Meninno, E. and Menon, A. S. Meres, M. Mhlanga, S. Miake, Y. and Micheletti, L. Migliorin, L. C. Mihaylov, D. L. Mikhaylov, K. Mishra, A. N. Miskowiec, D. Modak, A. Mohanty, A. P. and Mohanty, B. Khan, M. Mohisin Moravcova, Z. Mordasini, C. and De Godoy, D. A. Moreira Moreno, L. A. P. Morozov, I. and Morsch, A. Mrnjavac, T. Muccifora, V. Mudnic, E. and Muhlheim, D. Muhuri, S. Mulligan, J. D. Mulliri, A. and Munhoz, M. G. Munzer, R. H. Murakami, H. Murray, S. and Musa, L. Musinsky, J. Myers, C. J. Myrcha, J. W. Naik, B. Nair, R. Nandi, B. K. Nania, R. Nappi, E. Naru, M. U. Nassirpour, A. F. Nath, A. Nattrass, C. Neagu, A. and Nellen, L. Nesbo, S. V. Neskovic, G. Nesterov, D. and Nielsen, B. S. Nikolaev, S. Nikulin, S. Nikulin, V. and Noferini, F. Noh, S. Nomokonov, P. Norman, J. Novitzky, N. Nowakowski, P. Nyanin, A. Nystrand, J. Ogino, M. and Ohlson, A. Okorokov, V. A. Oleniacz, J. Da Silva, A. C. Oliveira Oliver, M. H. Onnerstad, A. Oppedisano, C. and Ortiz Velasquez, A. Osako, T. Oskarsson, A. Otwinowski, J. and Oyama, K. Pachmayer, Y. Padhan, S. Pagano, D. Paic, G. Palasciano, A. Pan, J. Panebianco, S. Pareek, P. and Park, J. Parkkila, J. E. Pathak, S. P. Patra, R. N. and Paul, B. Pazzini, J. Pei, H. Peitzmann, T. Peng, X. and Pereira, L. G. Pereira Da Costa, H. Peresunko, D. Perez, G. M. Perrin, S. Pestov, Y. Petracek, V. Petrovici, M. and Pezzi, R. P. Piano, S. Pikna, M. Pillot, P. Pinazza, O. and Pinsky, L. Pinto, C. Pisano, S. Ploskon, M. and Planinic, M. Pliquett, F. Poghosyan, M. G. Polichtchouk, B. and Politano, S. Poljak, N. Pop, A. Porteboeuf-Houssais, S. and Porter, J. Pozdniakov, V. Prasad, S. K. Preghenella, R. and Prino, F. Pruneau, C. A. Pshenichnov, I. Puccio, M. and Qiu, S. Quaglia, L. Quishpe, R. E. Ragoni, S. and Rakotozafindrabe, A. Ramello, L. Rami, F. Ramirez, S. A. R. and Ramos, A. G. T. Rancien, T. A. Raniwala, R. Raniwala, S. and Rasanen, S. S. Rath, R. Ravasenga, I. Read, K. F. and Redelbach, A. R. Redlich, K. Rehman, A. Reichelt, P. and Reidt, F. Reme-ness, H. A. Renfordt, R. Rescakova, Z. and Reygers, K. Riabov, A. Riabov, V. Richert, T. Richter, M. Riegler, W. Riggi, F. Ristea, C. Rode, S. P. and Rodriguez Cahuantzi, M. Roed, K. Rogalev, R. Rogochaya, E. and Rogoschinski, T. S. Rohr, D. Rohrich, D. Rojas, P. F. and Torres, S. Rojas Rokita, P. S. Ronchetti, F. Rosano, A. and Rosas, E. D. Rossi, A. Rotondi, A. Roy, A. Roy, P. and Roy, S. Rubini, N. Rueda, O. V. Rui, R. Rumyantsev, B. Russek, P. G. Rustamov, A. Ryabinkin, E. Ryabov, Y. and Rybicki, A. Rytkonen, H. Rzesa, W. Saarimaki, O. A. M. and Sadek, R. Sadovsky, S. Saetre, J. Safarik, K. Saha, S. K. Saha, S. Sahoo, B. Sahoo, P. Sahoo, R. Sahoo, S. Sahu, D. Sahu, P. K. Saini, J. Sakai, S. Sambyal, S. Samsonov, V. Sarkar, D. Sarkar, N. Sarma, P. and Sarti, V. M. Sas, M. H. P. Schambach, J. Scheid, H. S. and Schiaua, C. Schicker, R. Schmah, A. Schmidt, C. Schmidt, H. R. Schmidt, M. O. Schmidt, M. Schmidt, N. V. Schmier, A. R. Schotter, R. Schukraft, J. Schutz, Y. Schwarz, K. and Schweda, K. Scioli, G. Scomparin, E. Seger, J. E. and Sekiguchi, Y. Sekihata, D. Selyuzhenkov, I. Senyukov, S. and Seo, J. J. Serebryakov, D. Serksnyte, L. Sevcenco, A. and Shaba, T. J. Shabanov, A. Shabetai, A. Shahoyan, R. and Shaikh, W. Shangaraev, A. Sharma, A. Sharma, H. Sharma, M. Sharma, N. Sharma, S. Sheibani, O. Shigaki, K. and Shimomura, M. Shirinkin, S. Shou, Q. Sibiriak, Y. and Siddhanta, S. Siemiarczuk, T. Silva, T. F. Silvermyr, D. and Simonetti, G. Singh, B. Singh, R. Singh, R. Singh, R. and Singh, V. K. Singhal, V. Sinha, T. Sitar, B. Sitta, M. Skaali, T. B. Skorodumovs, G. Slupecki, M. Smirnov, N. Snellings, R. J. M. Soncco, C. Song, J. Songmoolnak, A. Soramel, F. Sorensen, S. Sputowska, I. Stachel, J. and Stan, I. Steffanic, P. J. Stiefelmaier, S. F. Stocco, D. and Storehaug, I. Storetvedt, M. M. Stylianidis, C. P. and Suaide, A. A. P. Sugitate, T. Suire, C. Suljic, M. and Sultanov, R. Sumbera, M. Sumberia, V. Sumowidagdo, S. and Swain, S. Szabo, A. Szarka, I. Tabassam, U. Taghavi, S. F. Taillepied, G. Takahashi, J. Tambave, G. J. Tang, S. and Tang, Z. Tarhini, M. Tarzila, M. G. Tauro, A. Tejeda Munoz, G. Telesca, A. Terlizzi, L. Terrevoli, C. and Tersimonov, G. Thakur, S. Thomas, D. Tieulent, R. and Tikhonov, A. Timmins, A. R. Tkacik, M. Toia, A. and Topilskaya, N. Toppi, M. Torales-Acosta, F. Tork, T. and Trifiro, A. Tripathy, S. Tripathy, T. Trogolo, S. and Trombetta, G. Trubnikov, V. Trzaska, W. H. Trzcinski, T. P. and Trzeciak, B. A. Tumkin, A. Turrisi, R. Tveter, T. S. and Ullaland, K. Uras, A. Urioni, M. Usai, G. L. Vala, M. and Valle, N. Vallero, S. van der Kolk, N. van Doremalen, L. V. R. van Leeuwen, M. Vyvre, P. Vande Varga, D. Varga, Z. Varga-Kofarago, M. Vargas, A. Vasileiou, M. Vasiliev, A. Doce, O. Vazquez Vechernin, V. Vercellin, E. Limon, S. Vergara Vermunt, L. Vertesi, R. Verweij, M. Vickovic, L. Vilakazi, Z. Baillie, O. Villalobos Vino, G. and Vinogradov, A. Virgili, T. Vislavicius, V. Vodopyanov, A. and Volkel, B. Volkl, M. A. Voloshin, K. Voloshin, S. A. and Volpe, G. von Haller, B. Vorobyev, I. Voscek, D. and Vrlakova, J. Wagner, B. Wang, C. Wang, D. Weber, M. and Weelden, R. J. G. V. Wegrzynek, A. Wenzel, S. C. Wessels, J. P. Wiechula, J. Wikne, J. Wilk, G. Wilkinson, J. and Willems, G. A. Windelband, B. Winn, M. Witt, W. E. and Wright, J. R. Wu, W. Wu, Y. Xu, R. Yalcin, S. and Yamaguchi, Y. Yamakawa, K. Yang, S. Yano, S. Yin, Z. and Yokoyama, H. Yoo, I-K. Yoon, J. H. Yuan, S. Yuncu, A. and Zaccolo, V. Zaman, A. Zampolli, C. Zanoli, H. J. C. and Zardoshti, N. Zarochentsev, A. Zavada, P. Zaviyalov, N. and Zbroszczyk, H. Zhalov, M. Zhang, S. Zhang, X. Zhang, Y. and Zherebchevskii, V. Zhi, Y. Zhou, D. Zhou, Y. Zhu, J. and Zhu, Y. Zichichi, A. Zinovjev, G. Zurlo, N. A Large Ion Collider Experiment

Subjects
Nuclear Theory, High Energy Physics::Phenomenology, High Energy Physics::Experiment, Nuclear Experiment
Abstract

The p(T)-differential cross sections of prompt charm-strange baryons Xi(0)(c) and Xi(+)(c) were measured at midrapidity (vertical bar y vertical bar < 0.5) in proton-proton (pp) collisions at a center-of-mass energy root s = 13 TeV with the ALICE detector at the LHC. The Xi(0)(c) baryon was reconstructed via both the semileptonic decay (Xi(-)e(+)nu(e)) and the hadronic decay (Xi(-)pi(+)) channels. The Xi(+)(c) baryon was reconstructed via the hadronic decay (Xi(-)pi(+)pi(+)) channel. The branching-fraction ratio BR (Xi(0)(c) -> Xi(-)e(+)nu(e))/BR(Xi(0)(c) -> Xi(-)pi(+)) = 1.38 +/- 0.14(stat) +/- 0.22(syst) was measured with a total uncertainty reduced by a factor of about 3 with respect to the current world average reported by the Particle Data Group. The transverse momentum (p(T)) dependence of the Xi(0)(c)- and Xi(+)(c)-baryon production relative to the D-0 meson and to the Sigma(0,+,+,+)(c)- and Lambda(+)(c)-baryon production are reported. The baryon-to-meson ratio increases toward low p(T) up to a value of approximately 0.3. The measurements are compared with various models that take different hadronization mechanisms into consideration. The results provide stringent constraints to these theoretical calculations and additional evidence that different processes are involved in charm hadronization in electron-positron (e(+)e(-)) and hadronic collisions.

Published
2021

8. Focusing on Diabetic Ulcers

Author

C, Setacci, D, Benevento, G, De Donato, E, Viviani, U M, Bracale, L, Del Guercio, G, Palasciano, and F, Setacci

Subjects
Letter to Editor
Abstract

Foot ulcers associated with Diabetes mellitus require immediate attention due to risk of amputation if left untreated. Herein we focus on the mitigating risk factors and physiopathology of the diabetic foot, recounting our own surgical approach and revascularization procedures.

Published
2020

9. A comparison of clinical outcomes of abdominal aortic aneurysm patients with favorable and hostile neck angulation treated by endovascular repair with the Treovance stent graft

Author

Feras Abdallah, Carlo Setacci, Domenico Benevento, David Murray, Raman Uberoi, Zoltán Szeberin, G. Palasciano, and Mario Lescan

Subjects
Male, medicine.medical_specialty, Time Factors, Post hoc, medicine.medical_treatment, Subgroup analysis, 030204 cardiovascular system & hematology, Prosthesis Design, 03 medical and health sciences, Blood Vessel Prosthesis Implantation, 0302 clinical medicine, Aneurysm, Postoperative Complications, Maximum diameter, Risk Factors, medicine.artery, medicine, 80 and over, Humans, Abdominal, Angulation, Aorta, Endovascular, Aged, Aged, 80 and over, Aortic Aneurysm, Abdominal, Endovascular Procedures, Female, Product Surveillance, Postmarketing, Prospective Studies, Registries, Treatment Outcome, Blood Vessel Prosthesis, Stents, 030212 general & internal medicine, business.industry, Significant difference, Stent, medicine.disease, Abdominal aortic aneurysm, Surgery, Aortic Aneurysm, Product Surveillance, Postmarketing, Cardiology and Cardiovascular Medicine, business
Abstract

Objective The objective of this study was to compare outcomes of patients with favorable neck angulation (FNA) and hostile neck angulation (HNA) treated with the Treovance stent graft (Terumo Aortic [formerly Bolton Medical], Sunrise, Fla). Methods Patients with abdominal aortic aneurysms suitable for endovascular repair with Treovance were included in the RATIONALE postmarket surveillance registry. A post hoc subgroup analysis compared patients with infrarenal neck angles Results After 1 year, 179 FNA (89.5%) and 21 HNA (10.5%) patients were analyzed. Both groups were similar in terms of sex (male, 92.7% FNA and 95.2% HNA) and age (73.0 years vs 72.6 years), but the HNA group had more Asian or other race representation (7.3% vs 19.0%) and more patients assigned to American Society of Anesthesiologists class 3 and class 4 (57.6% vs 66.7%). Mean suprarenal angles (standard deviation) were 13.1 (±13.5) degrees vs 29.0 (±16.4) degrees; mean infrarenal angles were 23.2 (±16.4) degrees vs 65.4 (±4.6) degrees, respectively. Aneurysm sac size maximum diameter was 58.1 (±9.8) mm vs 62.0 (±14.1) mm. There was a significant difference in unplanned adjunctive procedures (2.2% vs 19.0%; P = .01). Mean procedural duration was also significantly different for HNA patients, who underwent protracted operations (111.3 [±47.3] minutes vs 153.5 [±44.5] minutes; P Conclusions Patients with high neck angulation treated with Treovance underwent more complex procedures but showed equally good technical success and 1-year clinical success parameters.

Published
2020

11. Poster session Thursday 6 December - AM: Other myocardial diseases

Author

Z. Ojaghi-Haghighi, A. Mostafavi, H. Moladoust, F. Noohi, M. Maleki, M. Esmaeilzadeh, N. Samiei, S. Hosseini, R. Jasaityte, A. Teske, P. Claus, B. Verheyden, F. Rademakers, J. D'hooge, A. Patrianakos, A. Zacharaki, A. Kalogerakis, E. Nyktari, P. Maniatakis, F. Parthenakis, P. Vardas, J. M. Hilde, I. Skjoerten, S. Humerfelt, V. Hansteen, M. Melsom, J. Hisdal, K. Steine, R. Ippolito, P. Gripari, D. Muraru, R. Esposito, G. Kocabay, G. Tamborini, M. Galderisi, F. Maffessanti, L. Badano, M. Pepi, S. Yurdakul, F. Oner, T. Sahin, B. Avci, Y. Tayyareci, H. Direskeneli, S. Aytekin, T. Filali, B. Jedaida, D. Lahidheb, M. Gommidh, H. Mahfoudhi, N. Hajlaoui, R. Dahmani, W. Fehri, H. Haouala, V. Andova, L. Georgievska-Ismail, E. Srbinovska-Kostovska, Y. Gardinger, J. Joanna Hlebowicz, O. Ola Bjorgell, M. Magnus Dencker, M.-T. Liao, C.-T. Tsai, J.-L. Lin, K. Piestrzeniewicz, K. Luczak, M. Maciejewski, J. Komorowski, J. Jankiewicz-Wika, J. Drozdz, M. F. Ismail, A. Alasfar, M. Elassal, S. El-Sayed, M. Ibraheim, P. Dobrowolski, A. Klisiewicz, E. Florczak, A. Prejbisz, E. Szwench, J. Rybicka, A. Januszewicz, P. Hoffman, M. Santos Furtado, K. Nogueira, A. Arruda, A. C. Rodrigues, F. Carvalho, M. Silva, A. Cardoso, E. Lira-Filho, J. Pinheiro, J. L. Andrade, M. Mohammed, C. Zito, M. Cusma-Piccione, G. Di Bella, N. Taha, D. Zagari, A. Oteri, A. Quattrone, I. Boretti, S. Carerj, O. Obremska, B. Boratynska, P. Poczatek, Z. Zon, M. Magott, K. Klinger, O. Szenczi, Z. Szelid, P. Soos, Z. Bagyura, E. Edes, P. Jozan, B. Merkely, J. Ahn, D. Kim, D. Jeon, I. Kim, F. Baeza Garzon, M. Delgado, D. Mesa, M. Ruiz, J. S. De Lezo, M. Pan, C. Leon, F. Castillo, M. Morenate, F. Toledano, L. Zhong, E. Lim, N. Shanmugam, S. Law, B. Ong, K. Katwadi, R. Tan, Y. Chua, R. Liew, Z. Ding, H. Von Bibra, C. Leclerque, T. Schuster, P.-M. Schumm-Draeger, M. Bonios, A. Kaladaridou, O. Papadopoulou, A. Tasoulis, C. Pamboucas, A. Ntalianis, J. Nanas, S. Toumanidis, D. Silva, N. Cortez-Dias, P. Carrilho-Ferreira, R. Placido, C. Jorge, C. Calisto, S. Robalo Martins, J. Carvalho De Sousa, F. Pinto, A. Nunes Diogo, M. Przewlocka-Kosmala, A. Orda, B. Karolko, A. Mysiak, W. Kosmala, S. Moral Torres, J. Rodriguez-Palomares, V. Pineda, D. Gruosso, A. Evangelista, D. Garcia-Dorado, J. Figueras, E. Cambronero, M. J. Corbi, A. Valle, J. Cordoba, C. Llanos, M. Fernandez, I. Lopez, V. Hidalgo, M. Barambio, J. Jimenez, A. D'andrea, L. Riegler, R. Cocchia, M. Russo, E. Bossone, R. Calabro, A. Iniesta Manjavacas, S. Valbuena Lopez, T. Lopez Fernandez, S. Garcia-Blas, F. De Torres Alba, J. G. De Diego, U. Ramirez Valdiris, J. Mesa Garcia, M. Moreno Yanguela, J. Lopez-Sendon, B. Logstrup, H. Andersen, L. Thuesen, E. Christiansen, K. Terp, K. Klaaborg, S. Poulsen, A. Cacicedo, S. Velasco, U. Aguirre, J. Onaindia, I. Rodriguez, G. Oria, A. Subinas, G. Zugazabeitia, A. Romero, E. Laraudogoitia Zaldumbide, S. Weisz, J. Magne, R. Dulgheru, M. Rosca, L. Pierard, P. Lancellotti, V. Auffret, E. Donal, M. Bedossa, D. Boulmier, M. Laurent, J. Verhoye, H. Le Breton, S. Van Hall, T. Herbrand, U. Ketterer, S. Keymel, Y. Boering, T. Rassaf, C. Meyer, T. Zeus, M. Kelm, J. Balzer, M. Floria, S. Seldrum, M. Mariciuc, G. Laurence, M. Buche, P. Eucher, Y. Louagie, J. Jamart, B. Marchandise, E. Schroeder, A. Venkatesh, A. Sahlen, J. Johnson, L. Brodin, R. Winter, K. Shahgaldi, A. Manouras, L. Fusini, M. Muratori, F. Alamanni, A. Bartorelli, C. Ferrari, E. Caiani, E. Yaroslavskaya, V. Kuznetsov, G. Pushkarev, D. Krinochkin, I. Zyrianov, C. Ciobotaru, Y. Kobayashi, K. Yamamoto, E. Hirose, A. Hirohata, T. Ohe, P. Jhund, T. Cunningham, V. Murday, I. Findlay, P. Sonecki, I. Rangel, C. Sousa, A. Goncalves, A. Correia, A. Vigario, E. Martins, J. Silva-Cardoso, F. Macedo, M. Maciel, D. Lovric, J. Samardzic, D. Milicic, V. Reskovic, Z. Baricevic, I. Ivanac, J. Separovic Hanzevacki, K. Kim, J. Song, H. Jeong, H. Yoon, Y. Ahn, M. Jeong, J. Cho, J. Park, J. Kang, A. Iorio, B. Pinamonti, M. Bobbo, M. Merlo, G. Barbati, L. Massa, G. Faganello, A. Di Lenarda, G. Sinagra, F. Heggemann, K. Hamm, F. Streitner, T. Sueselbeck, T. Papavassiliu, M. Borggrefe, D. Haghi, F. Ferreira, A. Galrinho, R. Soares, L. Branco, J. Abreu, J. Feliciano, A. Papoila, M. Alves, A. Leal, R. Ferreira, A. Reynaud, L. H. Lund, E. Oger, E. Drouet, C. Hage, F. Bauer, C. Linde, J. Daubert, F. Schnell, P. Lentz, G. Kervio, G. Leurent, P. Mabo, F. Carre, A. Rodrigues, M. Roque, D. Becker, S. Barros, F. Kay, T. Emerick, P. Sampaio-Barros, J. Andrade, S. Yamada, K. Okada, H. Iwano, H. Nishino, M. Nakabachi, S. Yokoyama, S. Kaga, T. Mikami, H. Tsutsui, R. Mincu, S. Magda, S. Dumitrache Rujinski, T. Constantinescu, S. Mihaila, A. Ciobanu, M. Florescu, D. Vinereanu, T. Ashcheulova, O. Kovalyova, E. Ardeleanu, D. Gurgus, A. Gruici, R. Suciu, I. Ana, L. Bergenzaun, H. Ohlin, P. Gudmundsson, R. Willenheimer, M. Chew, A. Charalampopoulos, L. Howard, R. Davies, W. Gin-Sing, I. Tzoulaki, I. Grapsa, S. Gibbs, P. Massabuau, L. Weinert, O. Lairez, M. Berry, M. Sotaquira, P. Vaida, R. Lang, I. Khan, D. Waterhouse, S. Asegdom, M. Alqaseer, D. Foley, B. Mcadam, P. Colonna, E. Michelotto, W. Genco, M. Rubino, S. Pugliese, A. Belfiore, M. Sorino, M. Trisorio Liuzzi, G. Antonelli, G. Palasciano, A. Duszanska, I. Skoczylas, W. Streb, T. Kukulski, L. Polonski, Z. Kalarus, A. Fleig, K. Seitz, S. Secades, M. Martin, C. Corros, M. Rodriguez, J. De La Hera, A. Garcia, E. Velasco, E. Fernandez, V. Barriales, J. Lambert, D. R. Zwas, S. Hoss, D. Leibowitz, R. Beeri, C. Lotan, D. Gilon, K. Wierzbowska-Drabik, N. Roszczyk, M. Sobczak, M. Plewka, L. Chrzanowski, P. Lipiec, J. Kasprzak, K. Wita, K. Mizia-Stec, W. Wrobel, E. Plonska-Gosciniak, T. Pinho, Y. Wang, H. Houle, A. J. Madureira, J. Zamorano, M. J. Maciel, R. Ancona, S. Comenale Pinto, P. Caso, M. Coppola, O. Rapisarda, R. Calabro', R. Cadenas Chamorro, T. Lopez, J. Gomez, M. Moreno, P. Salinas, C. Jimenez Rubio, S. Valbuena, A. Manjavacas, F. De Torres, T. Vaugrenard, O. Huttin, A. Rouge, J. Schwartz, P. Zinzius, B. Popovic, J. Sellal, E. Aliot, Y. Juilliere, C. Selton-Suty, J. Looi, A. Lee, M. Hsiung, W. Song, R. Wong, M. J. Underwood, F. Fang, Q. Lin, Y. Lam, C. Yu, A. Vitarelli, B. Nguyen, L. Capotosto, G. D-Alessandro, M. D-Ascanio, A. Rafique, E. Gang, F. Barilla, R. Siegel, A. Kydd, F. Khan, W. Watson, L. Mccormick, M. Virdee, D. Dutka, S. Ranjbar, M. Karvandi, S. Hassantash, J. Grapsa, I. Efthimiadis, T. Pakrashi, D. Dawson, P. Punjabi, P. Nihoyannopoulos, M. Henein, S. Soderberg, E. Tossavainen, P. Lindqvist, H. Bellsham-Revell, A. Bell, O. Miller, J. Simpson, E. Altekin, M. Kucuk, A. Yanikoglu, S. Karakas, A. Er, D. Ozel, C. Ermis, I. Demir, G. Bajraktari, G. Di Salvo, L. Baldini, F. Del Gaizo, A. Rea, V. Pergola, G. Pacileo, B. Fadel, J.-S. Seo, G.-N. Choi, H.-Y. Jin, S.-H. Seol, J.-S. Jang, T.-H. Yang, D.-K. Kim, D.-S. Kim, E. Papadopoulou, S. Hatzidou, J. Agrios, C. Pamboukas, A. Antoniou, P. Gargiulo, S. Dellegrottaglie, D. Bruzzese, O. Scala, C. D'amore, D. Ruggiero, C. Marciano, E. Vassallo, E. Pirozzi, P. Perrone Filardi, V. Mor-Avi, N. Kachenoura, J. Lodato, S. Port, S. Chandra, B. Freed, N. Bhave, B. Newby, A. Patel, G. Dwivedi, M. Alam, K. Boczar, B. Chow, G. Staskiewicz, E. Czekajska-Chehab, S. Uhlig, A. Tomaszewski, J. Przegalinski, R. Maciejewski, A. Drop, G. Di Giammarco, C. Canosa, M. Foschi, G. Liberti, M. Bedir, D. Marinelli, S. Masuyama, R. Rabozzi, S. Vijayan, H. Miller, R. Muthusamy, S. Smith, L. Gargani, P. Pang, E. Davis, A. Schumacher, R. Sicari, E. Picano, A. Chmiel, M. Mizia, M. Haberka, K. Gieszczyk, A. Sikora - Puz, B. Lasota, O. Trojnarska, S. Grajek, Z. Gasior, A. Koumoulidis, I. Vlasseros, D. Tousoulis, V. Katsi, A. Avgeropoulou, M. Divani, C. Stefanadis, and I. Kallikazaros

Subjects
medicine.medical_specialty, business.industry, Internal medicine, Cardiology, medicine, Radiology, Nuclear Medicine and imaging, General Medicine, Function (mathematics), Cardiology and Cardiovascular Medicine, Independent predictor, business, Ventricular geometry
Published
2012
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13. Erectile dysfunction and alcohol intake

Author

G. Dachille, M. Lamuraglia, M. Leone, A. Pagliarulo, G. Palasciano, M.T. Salerno, and G.M. Ludovico

Subjects
03 medical and health sciences, 0302 clinical medicine, 030220 oncology & carcinogenesis, 030232 urology & nephrology, General Medicine
Abstract

The objective of this work is to evaluate in a selection of patients with erectile dysfunction the influence of alcohol consumption and the response to alcohol abstinence with and without sildenafil association. Materials and Methods. In a population of 150 consecutive patients with erectile dysfunction we studied 50 patients aged between 22 and 77 years (mean 56±14 SD). These 50 patients were divided into three different treatment groups and were screened for three different levels of alcohol risk with two questionnaires. All patients were evaluated with an International Index Erectile Dysfunction (IIEF) questionnaire before and after one month of treatment. Results. The 50 patients included 14 patients with high alcohol risk, 34 patients with low alcohol risk and only 2 patients with no alcohol risk. After one month, 29 patients responded to the therapy, and 21 did not respond. The IIEF questionnaire presented a statistically significant difference between the different risk groups before and after treatment (p≤0.05). All the patients were examined with a penile Doppler Ultrasound. Only 10 of them had an abnormal diastolic peak velocity (PDV) and only 1 presented both pathologic systolic peak velocity (PSV) and PDV. These 11 patients did not respond to therapies and 10 of them were at high alcohol risk. The alcohol consumption risk was directly correlated with PDV (p=0.00001; R=0.4). Conclusions. The results of this study demonstrated a significant relationship between alcohol consumption and erectile dysfunction. This underlines the important therapeutic issue of alcohol abstinence in treating patients with erectile dysfunction.

Published
2008
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16. Renal aneurysms: surgical vs. endovascular treatment

Author

E, Chisci, F, Setacci, G, de Donato, A, Cappelli, G, Palasciano, and C, Setacci

Subjects
Evidence-Based Medicine, Renal Artery, Treatment Outcome, Elective Surgical Procedures, Risk Factors, Patient Selection, Endovascular Procedures, Humans, Aneurysm, Ruptured, Aneurysm, Risk Assessment, Vascular Surgical Procedures
Abstract

Renal artery aneurysms (RAA) are rare (general population incidence is 0.09%). At this time, the appropriateness of the type of intervention ‑ surgical or endovascular ‑ is based on single center experiences rather than large randomized trials. Endovascular therapy offers less morbidity but surgery has excellent long-term results. In reality, the choice of the treatment relies on the operative risk. A patient with a RAA and good surgical risk should be offered open surgery. If the patient is deemed to be at high risk from surgery then the choice of the type of endovascular treatment (stent grafting, coil/glue embolization, multilayer stenting) should be based on the location and shape of the RAA. RAA should be treated by surgeons/interventionalists who have demonstrated expertise in renal artery procedures.

Published
2011

17. Erectile dysfunction and alcohol intake

Author

G, Dachille, M, Lamuraglia, M, Leone, A, Pagliarulo, G, Palasciano, M T, Salerno, and G M, Ludovico

Abstract

The objective of this work is to evaluate in a selection of patients with erectile dysfunction the influence of alcohol consumption and the response to alcohol abstinence with and without sildenafil association. Materials and Methods. In a population of 150 consecutive patients with erectile dysfunction we studied 50 patients aged between 22 and 77 years (mean 56±14 SD). These 50 patients were divided into three different treatment groups and were screened for three different levels of alcohol risk with two questionnaires. All patients were evaluated with an International Index Erectile Dysfunction (IIEF) questionnaire before and after one month of treatment. RESULTS. The 50 patients included 14 patients with high alcohol risk, 34 patients with low alcohol risk and only 2 patients with no alcohol risk. After one month, 29 patients responded to the therapy, and 21 did not respond. The IIEF questionnaire presented a statistically significant difference between the different risk groups before and after treatment (p≤0.05). All the patients were examined with a penile Doppler Ultrasound. Only 10 of them had an abnormal diastolic peak velocity (PDV) and only 1 presented both pathologic systolic peak velocity (PSV) and PDV. These 11 patients did not respond to therapies and 10 of them were at high alcohol risk. The alcohol consumption risk was directly correlated with PDV (p=0.00001; R2=0.4). CONCLUSIONS. The results of this study demonstrated a significant relationship between alcohol consumption and erectile dysfunction. This underlines the important therapeutic issue of alcohol abstinence in treating patients with erectile dysfunction.

Published
2010

18. Beneficial effects of oral tilactase on patients with hypolactasia

Author

P, Portincasa, A, Di Ciaula, M, Vacca, R, Montelli, D Q-H, Wang, and G, Palasciano

Subjects
Adult, Aged, 80 and over, Male, Adolescent, Administration, Oral, Middle Aged, beta-Galactosidase, Abdominal Pain, Young Adult, Lactose Intolerance, Breath Tests, Humans, Female, Gastrointestinal Transit, Aged, Hydrogen
Abstract

A lactose-free diet is commonly prescribed to subjects with hypolactasia. We tested the effectiveness of a single ingestion of tilactase (a beta-D-galactosidase from Aspergillus oryzae) in adults with hypolactasia, previously assessed by lactose H(2)-breath test.After measurement of orocecal transit time (OCTT, by lactulose H(2)-breath test) and lactose H(2)-breath testing plus placebo, a total of 134 subjects were positive to hypolactasia and underwent lactose H(2)-breath testing plus either low (6750 U) or standard (11,250 U) doses of tilactase. The appearance of gastrointestinal symptoms during the tests was monitored.OCTT was longer in malabsorbers (subjects without bloating, abdominal pain and/or diarrhoea, n = 25) than in intolerants (bloating, abdominal pain and/or diarrhoea, n = 109, P0.02). Malabsorbers had longer time to H(2) peak (P0.03), lower H(2) peak levels (P0.002) and smaller integrated H(2) excretion levels (P0.005) than intolerants. After tilactase ingestion, integrated H(2) levels were decreased by 75% (low dose) and 87% (standard dose) in malabsorbers, and by 74% (low dose) and 88% (standard dose) in intolerants. In the latter group, total symptom score were decreased by 76% (low dose) and by 88% (standard dose) (P0.0001).A single oral administration of tilactase is highly effective in decreasing symptoms and hydrogen excretion of hypolactasia assessed by lactose H(2)-breath test. If confirmed by long-term observations, ingestion of tilactase might be a better option than exclusion diets in intolerant subjects with hypolactasia.

Published
2008

19. Aquaporins in the hepatobiliary tract. Which, where and what they do in health and disease

Author

P, Portincasa, G, Palasciano, M, Svelto, and G, Calamita

Subjects
Biliary Tract Diseases, Liver Diseases, Hepatocytes, Humans, Biological Transport, Kidney Diseases, Aquaporins, Biliary Tract
Abstract

The biological importance of the aquaporin family of water channels was recently acknowledged by the 2003 Nobel Prize for Chemistry awarded to the discovering scientist Peter Agre. Among the pleiotropic roles exerted by aquaporins in nature in both health and disease, the review addresses the latest acquisitions about the expression and regulation, as well as physiology and pathophysiology of aquaporins in the hepatobiliary tract. Of note, at least seven out of the thirteen mammalian aquaporins are expressed in the liver, bile ducts and gallbladder. Aquaporins are essential for bile water secretion and reabsorption, as well as for plasma glycerol uptake by the hepatocyte and its conversion to glucose during starvation. Novel data are emerging regarding the physio-pathological involvement of aquaporins in multiple diseases such as cholestases, liver cirrhosis, obesity and insulin resistance, fatty liver, gallstone formation and even microparasite invasion of intrahepatic bile ducts. This body of knowledge represents the mainstay of present and future research in a rapidly expanding field.

Published
2008

20. [Angiotensin converting enzyme inhibitors, angiotensin receptor blockers and combined therapy in microalbuminuric patients with one or more cardiovascular risk factors. Protocol of the Long-term Impact of RAS Inhibition on Cardiorenal Outcomes randomized trial (LIRICO).]

Author

A, Maione, A, Nicolucci, J C, Craig, G, Tognoni, A, Moschetta, G, Palasciano, G, Pugliese, D A, Procaccini, L, Gesualdo, F, Pellegrini, and G F M, Strippoli

Subjects
Angiotensin Receptor Antagonists, Cardiovascular Diseases, Risk Factors, Humans, Angiotensin-Converting Enzyme Inhibitors, Prospective Studies, Angiotensin II Type 1 Receptor Blockers
Abstract

Angiotensin converting enzyme inhibitors (ACE-i) and angiotensin II receptor blockers (ARB) are considered to be equally effective for patients with diabetic kidney disease, while only ACE-i have been shown to determine a significant reduction in the risk of all-cause mortality, predominantly cardiovascular, in these patients. Studies on the cardio-renal efficacy of combined therapy with ACE-i and ARB are not available or not conclusive, in a population with cardiovascular risk with micro- or macroalbuminuria. In this paper, we present the protocol of a randomized controlled clinical trial that will address the question. The LIRICO (Long-term Impact of RAS Inhibition on Cardiorenal Outcomes) study will evaluate the comparative efficacy for cardiovascular and renal outcomes of combined therapy with ACE-i and ARB versus monotherapy with ACE-i or ARB in micro/macroalbuminuric individuals at cardio-renal risk. The study will enrol 2100 patients allocated to monotherapy with ACE-i, ARB or combined treatment with ACE-i + ARB. The LIRICO study is a randomized comparative trial, with PROBE (Prospective Randomized Open Blinded End-Point) design. The study has been approved and funded by the Agenzia Italiana del Farmaco (AIFA) within the 2005 funding plan for independent research on drugs. Availability of funding for this study provides, for the first time in our Country, an opportunity to organize a collaborative national network of nephrology, internal medicine and diabetology outpatient clinics to develop a large multicentre trial collaboration. The results of this trial will establish the optimal therapy for micro/macroalbuminuric individuals with cardiovascular and renal risk.

Published
2007

21. Renovascular hypertension. 8 years experience of a vascular surgery centre

Author

G, de Donato, C, Setacci, E, Chisci, F, Setacci, and G, Palasciano

Subjects
Male, Hypertension, Renovascular, Treatment Outcome, Humans, Female, Stents, Endarterectomy, Middle Aged, Renal Artery Obstruction, Angioplasty, Balloon, Aged, Follow-Up Studies, Retrospective Studies
Abstract

The aim of this study was to evaluate the technical success and clinical outcome of surgical revascularization, angioplasty and/or stenting for renal artery stenosis (RAS) in patients with renovascular hypertension (RVH). The secondary aim was to identify independent negative predictors of blood pressure control after successful renal revascularization.From January 1998 to July 2006, we treated 97 cases of RAS in 83 RVH patients. Inclusion criteria were RASor =80% associated with hypertension refractory to medical control with at least three drugs including a diuretic. Therapeutic options were surgical revascularization in 15 cases (11 renal endarterectomies, 4 aortorenal bypasses) and endoluminal treatment in 82 (14 balloon angioplasties, 68 stents).Technical success was 100% for both surgical and endovascular procedures; 13 cases of restenosis (or =80%) were detected: 12 (14.6%) in the endoluminal group and one (6.6%) in the surgical group (P=0.68). During the follow-up period (average 37 months, range 6-94), blood pressure control improved in 43% of patients, disease stabilized in 37% and the natural course of RVH deteriorated in 20%. Multivariate Cox regression analysis showed that only a long history of antihypertensive drug use was a predictor of inefficacy of blood pressure control after revascularization (P0.04).The complete resolution of RVH associated with severe RAS appears unrealistic in several cases. Early and long-term results in terms of technical success and restenosis were acceptable and similar for surgical and endovascular renal intervention. An early diagnosis of RVH could improve the control of hypertension after successful renal revascularization.

Published
2007

22. Gallstone disease: Symptoms and diagnosis of gallbladder stones

Author

P, Portincasa, A, Moschetta, M, Petruzzelli, G, Palasciano, A, Di Ciaula, and A, Pezzolla

Subjects
Cholangiopancreatography, Endoscopic Retrograde, Diagnosis, Differential, Colic, Cholangiopancreatography, Magnetic Resonance, Abdomen, Cholecystitis, Bile, Humans, Gallstones, Sensitivity and Specificity, Ultrasonography
Abstract

The clinical aspects and the diagnostic features of gallstone disease are described. The natural history of silent gallstones is overviewed, and the risk of developing symptoms and complications is also discussed. The importance of colicky pain as a specific gallstone symptom is highlighted, and the role of both laboratory tests and diagnostic investigations for differential diagnosis is discussed. Finally, we describe the diagnostic features of gallbladder stone disease, including indications, sensitivity, specificity, and limitations of different test investigations under special circumstances.

Published
2006

23. [Acute pneumonia caused by aspiration of hydrocarbons in a fire-eater]

Author

L, Vimercati, A, Lorusso, S, Bruno, A, Carrus, S, Cappello, A, Belfiore, P, Portincasa, G, Palasciano, and G, Assennato

Subjects
Adult, Kerosene, Male, Occupational Diseases, Acute Disease, Humans, Pneumonia, Fires
Abstract

Accidental aspiration of fuel in fire eaters can cause an acute chemical pneumonitis known as 'fire-eater's pneumonia". We report a case in a 29 year-old fire-eater. Six hours after aspiration of kerosene, he developed fever up to 39,5 degrees C, dyspnea, cough and chest pain. Chest radiograph showed infiltrates in the middle and lower parts of the lungs and left pleural effusion. He was treated with an antibiotic and antipiretic therapy and then with corticosteroids. The acute stage lasted four weeks and the patient recovered without sequelae within 3 months. Hazard related to main fuels used for fire eating is discussed.

Published
2006

24. Extracorporeal blood oxygenation and ozonation (EBOO): A controlled trial in patients with peripheral artery disease

Author

I Ciari, Velio Bocci, Francesca Maccari, M. Di Paolo, F. Cappelletti, Francesco Galli, Diana Salvo, E. Gaggiotti, M Biagioli, Simone Meini, G Palasciano, and N. Di Paolo

Subjects
Male, medicine.medical_specialty, EBOO, Arterial disease, 030232 urology & nephrology, Biomedical Engineering, Medicine (miscellaneous), Bioengineering, Arterial Occlusive Diseases, 030204 cardiovascular system & hematology, Severity of Illness Index, Extracorporeal, law.invention, Biomaterials, 03 medical and health sciences, 0302 clinical medicine, Extracorporeal Membrane Oxygenation, Ozone, Randomized controlled trial, law, Skin Ulcer, medicine, Humans, In patient, Aged, Aged, 80 and over, Peripheral Vascular Diseases, business.industry, Extracorporeal circulation, General Medicine, Middle Aged, Ozone therapy, Epoprostenol, Surgery, Treatment Outcome, Anesthesia, Blood oxygenation, Female, business
Abstract

Background Since 1990 our group has been using extracorporeal circulation to ozonate blood by an original method, known as extracorporeal blood oxygenation and ozonation (EBOO), with the aim of amplifying the results observed with ozone autohemotherapy. Objective To verify the hypothesis that EBOO improves the skin lesions typical of peripheral artery disease (PAD) patients. Methods Twenty-eight patients with PAD were randomized to receive EBOO or intravenous prostacyclin in a controlled clinical trial. The primary efficacy parameters were regression of skin lesions and pain, and improvement in quality of life and vascularisation. Results Patients treated with EBOO showed highly significant regression of skin lesions with respect to patients treated with prostacyclin. Other parameters that were significantly different in the two groups of patients were pain, pruritus, heavy legs and well-being. No significant differences in vascularisation of the lower limbs before and after treatment were found in either group. No side effects or complications were recorded during the 210 EBOO treatments. Conclusion EBOO was much more effective than prostacyclin for treating skin lesions in PAD patients and also had a positive effect on patient general condition without any apparent change in arterial circulation. This suggests other mechanisms of action of EBOO.

Published
2005

25. [Quality guide in nephrology and dialysis]

Author

C, Manno, V, Palmieri, M, Virgilio, G, Palasciano, and F P, Schena

Subjects
Manuals as Topic, Nephrology, Renal Dialysis, Ambulatory Care Facilities
Abstract

The Quality Guide, a strategic tool for any nephrologist wishing to initiate a quality policy in his own renal unit, describes to the organisation of total quality management. This article gives a short description of a Quality Guide in Nephrology and Dialysis. According to ISO 9004:2000 Norms, the Quality Guide can be subdivided into four sections: Managerial Accountability, Resource Management; Implementation of Services; Analysis, Evaluation and Continuous Quality Improvement. The quality cycle begins by identifying the customers, who added to the resources constitute the input that will be transformed by the service into output (results). By measuring customer satisfaction the results will be evaluated and analyzed to allow continuous improvement of the service. In conclusion, the drafting of the Guide by all staff members involved has a twofold value: it organizes the quality management within the renal unit and certifies the quality level guaranteed to the customer.

Published
2004

26. Structural and oxidative modifications of erythrocyte ghosts in patients with primary biliary cirrhosis: relation with the disease stage and effect of bile acid treatment

Author

I, Grattagliano, A M, Giudetti, V, Grattagliano, V O, Palmieri, G V, Gnoni, G, Lapadula, G, Palasciano, and G, Vendemiale

Subjects
Adult, Cholesterol, Liver Cirrhosis, Biliary, Erythrocyte Membrane, Ursodeoxycholic Acid, Humans, Female, Blood Proteins, Middle Aged, Lipids, Oxidation-Reduction, Severity of Illness Index, Follow-Up Studies
Abstract

Erythrocyte membrane modifications in patients with cholestasis are supposed to reflect those of hepatocytes.Erythrocyte membrane composition (cholesterol, phospholipids, fatty acids, protein sulphydrils and carbonyls) was assessed and related to the stage of liver disease in patients with primary biliary cirrhosis before and after 1 year of ursodeoxycholate treatment.Compared with controls, patients showed lower levels of protein sulphydrils (28.9 +/- 7.1 vs. 65.6 +/- 1.8 nmol mg(-1) prot) and accumulation of carbonyls (4.7 +/- 1.7 vs. 1.4 +/- 0.1 nmol mg(-1) prot). Phosphatidylethanolamine level was lower in stage III-IV cirrhosis while phosphatidylcholine and cholesterol levels were higher; as a consequence the phosphatidylcholine/sphingomyelin ratio was higher than in controls (4.25 +/- 0.55 in the I-II stage and 2.89 +/- 0.44 in the stage III-IV vs. 1.61 +/- 0.30). These changes were particularly evident in patients with more advanced stages of liver disease. Protein sulphydrils and carbonyls, phosphatidylethanolamine and cholesterol levels correlated (P0.05) with the histological stage of the liver disease, serum and membrane cholesterol levels were significantly related (r=0.66, P0.05). One year of ursodeoxycholate administration was accompanied by major changes of the membrane lipid composition, partial reversal of protein oxidation, and improvement of serum parameters.This study indicates that major alterations in protein status and lipid composition occur in erythrocyte membrane of patients with primary biliary cirrhosis. These changes were more pronounced in patients with advanced liver disease. Ursodeoxycholate was able to revert in part serum and erythrocyte alterations, especially in patients with early stages of liver disease.

Published
2003

27. Experimental observations and clinical implications of fasting and diet supplementation in fatty livers

Author

I, Grattagliano, P, Portincasa, P, Caraceni, V O, Palmieri, M, Domenicali, M, Bernardi, and G, Palasciano

Subjects
Fatty Liver, Disease Models, Animal, Oxidative Stress, Dietary Supplements, Animals, Humans, Fasting, Obesity, Energy Metabolism, Diet Therapy
Abstract

Fatty accumulation per se does not appear to affect liver function; however, interest has recently renewed to fatty liver because of the clinical relevance of non alcoholic steato-hepatitis (NASH) and for the increased risk of post-transplant failure in grafted livers with steatosis. Clinical and experimental studies have doubtless demonstrated that oxidative stress ensues in steatotic livers. Mitochondria represent the preferential target of the oxidative injury associated to fatty degeneration and show reduced content of glutathione, higher levels of oxidative products and damages to enzymes involved in the process of ATP synthesis, which become more evident under stressing conditions. Although obese patients with fatty liver are advantaged by weight loss, clinical and experimental observations suggest that fatty livers poorly tolerate excessive food deprivation. These observations represent the rationale for treatment strategies based on the supplementation of antioxidants and energetic substrates rather than solely a diet restriction. This review focuses on data emerging from a series of investigations performed in rats with fatty livers induced by a choline-deficient diet, which resembles human steatosis due to an excessive intake of carbohydrates, and aims to give the cue for the development of therapeutic options able to preserve hepatic function after transplantation of steatotic organs.

Published
2003

28. Interleukins 1 beta and 6 induce functional alteration of rat colonic motility: an in vitro study

Author

L, Natale, A L, Piepoli, M A, De Salvia, G, De Salvatore, C I, Mitolo, A, Marzullo, P, Portincasa, A, Moschetta, G, Palasciano, and D, Mitolo-Chieppa

Subjects
Male, Neurotransmitter Agents, Colon, Interleukin-6, Cholinergic Agents, Neural Conduction, Muscle, Smooth, Rats, Electrophysiology, Rats, Sprague-Dawley, Tachykinins, Animals, Carbachol, Intestinal Mucosa, Gastrointestinal Motility, Miotics, Interleukin-1, Muscle Contraction
Abstract

In rodents, interleukins administration induces intestinal changes similar to those found in inflammatory bowel disease. We investigated the effects of in vivo subchronic treatment with IL-1 beta and IL-6 on rat colonic mucosa and circular smooth muscle.We evaluated transmucosal electrical parameters (Ussing chambers) and early changes of in vitro direct contractility induced by carbachol and tachykinins. Alterations in excitatory and inhibitory neurotransmission were studied with electrical field stimulation (EFS).Treatment with interleukins induces inflammation proved by fever, early signs of colonic histological damage and changes in mucosal ion transport. Concentration response-curve to carbachol was significantly lower in treated rats (P0.02) with significant difference in Emax between control (1.67+/-0.17 g) and treated preparations (1.20+/-0.13 g) (P0.05). Concentration response-curve to NK2 agonist was significantly lower in the treated rats (P0.005) with a significant difference in Emax between the control (0.26+/-0.04 g) and treated preparations (0.12+/-0.02 g) (P0.02). None of the drugs used induces changes in EC50. The contractile reflex response to electrically induced distension was significantly higher in the treated rats and more reduced after administration of atropine. Adding NK2 receptor antagonist resulted in a further reduction being observed in the treated and control rats (P=NS). Relaxation by EFS on cholinergic tone was not different between treatments, although pretreatment with L-NNA resulted in greater relaxation in the treated (-21.7%) than in the control rats (-14.8%).Early inflammation induced by a subchronic treatment with ILs causes changes in mucosal ionic transport parameters, a reduction in the direct contractile response, and an alteration in the neurotransmission (by an enhancing cholinergic component) that may affect the physiological pattern of colonic motility and the sensory reflex.

Published
2003

29. Sphingomyelin protects against apoptosis and hyperproliferation induced by deoxycholate: potential implications for colon cancer

Author

A, Moschetta, P, Portincasa, K J, van Erpecum, L, Debellis, G P, Vanberge-Henegouwen, and G, Palasciano

Subjects
Enzyme Precursors, Time Factors, Dose-Response Relationship, Drug, Caspase 3, Caspases, Colonic Neoplasms, Humans, Apoptosis, Caco-2 Cells, Cell Division, Deoxycholic Acid, Sphingomyelins
Abstract

High fecal deoxycholate levels may promote colonic cancer. Phospholipids protect against bile salt-induced cytotoxicity. We therefore aimed to examine whether the dietary phospholipid sphingomyelin could decrease hyperproliferation induced by deoxycholate. In CaCo2 cells, hyperproliferation (by bromodeoxyuridine assay), phosphorylation state of cellular proteins, and apoptosis with concomitant caspase-3 activity were evaluated after incubation with 50-500 microM deoxycholate, with or without sphingomyelin. At 2 and 4 hr of incubation, deoxycholate induced dose-dependent apoptosis, with concomitant caspase-3 activation. At 16 hr, apoptosis had decreased markedly, but there was dose-dependent hyperproliferation (with changed phosphorylation status of cellular proteins) at this time point. Sphingomyelin dose-dependently reduced deoxycholate-induced apoptosis and hyperproliferation. In conclusion, sphingomyelin reduces deoxycholate-induced hyperproliferation and apoptosis. These findings may have implications for colonic cancer prevention by dietary modification.

Published
2003

30. Diffuse gastrointestinal dysmotility by ultrasonography, manometry and breath tests in colonic inertia

Author

P, Portincasa, A, Moschetta, M, Giampaolo, and G, Palasciano

Subjects
Adult, Colonic Diseases, Breath Tests, Manometry, Humans, Female, Gastrointestinal Motility, Ultrasonography
Abstract

Patients with colonic inertia, the most severe form of chronic functional constipation, may present with a more diffuse panenteric motility disorder. We describe a case of a woman with severe longstanding colonic inertia associated with chronic functional dyspepsia and defective gastric, gallbladder and small intestinal motility, as confirmed by several diagnostic tests including two breath tests with the 13C-stable isotope. A subclinical form of authonomic sympathetic neuropathy was diagnosed, providing a possible pathophysiological explanation for the presence of simultaneous multiple motility defects of the gastrointestinal tract.

Published
2001

31. Changes of gallbladder and gastric dynamics in patients with acute hepatitis A

Author

P, Portincasa, A, Moschetta, A, Di Ciaula, V O, Palmieri, M, Milella, G, Pastore, and G, Palasciano

Subjects
Adult, Male, Gallbladder Emptying, Gastric Emptying, Acute Disease, Appetite, Gallbladder, Humans, Female, Dyspepsia, Hepatitis A, Gastrointestinal Motility
Abstract

Transient alterations of gallbladder morphology and dynamics have been reported in patients with during acute hepatitis A. The presence of dyspepsia also suggests involvement of gastric motility. During a 60-day follow-up, we investigated gallbladder and gastric motility in relation to dyspepsia in acute viral hepatitis A patients. Twenty patients were assessed at referral (day 0) and at days 7, 21, 42 and 60 and compared with 20 healthy volunteers. Gallbladder morphology and motility and gastric motility were assessed in the fasting and postprandial period by functional ultrasonography using a liquid test meal. Dyspeptic symptoms were scored. At day 0, fasting gallbladder volume was 5.9 +/- 1.3 mL, 32.6 +/- 4.6 mL, and 21.5 +/- 1.9 mL (mean +/- SE) in patients with gallbladder sludge (n = 7), without sludge (n = 13) and controls, respectively (P0.05 in sludge vs. no sludge and controls; P0.05 in no sludge vs. controls, ANOVA). Small fasting gallbladder volume in patients with sludge increased and sludge disappeared within 7 days. At day 0, patients with sludge also had increased thickness of fasting gallbladder wall and increased serum transaminase levels compared with patients without sludge and controls. Gallbladder contraction was similar in patients and controls. However, patients had delayed gastric emptying, which positively correlated with dyspepsia score. Gallbladder morphological changes observed in the acute phase of hepatitis A are transient and are associated with hepatocellular damage. Gastric emptying is delayed during the first week of disease and is associated with dyspeptic symptoms.

Published
2001

32. Review article: in vitro studies of gall-bladder smooth muscle function. Relevance in cholesterol gallstone disease

Author

P, Portincasa, F, Minerva, A, Moschetta, N, Venneman, G P, Vanberge-Henegouwen, and G, Palasciano

Subjects
Bile Acids and Salts, Cholesterol, Cholelithiasis, Gallbladder, Humans, Muscle, Smooth, Gastrointestinal Motility, Postprandial Period, Muscle Contraction
Abstract

The interplay between contraction and relaxation in the gall-bladder muscularis leads to appropriate gall-bladder emptying and refilling during fasting and in the postprandial state in vivo. Several studies in both human and animal models have focused on cellular and molecular events in the gall-bladder wall in health and disease in vitro. Principal methods to study gall-bladder smooth muscle function include receptor binding studies (at the level of plasmamembranes or histological sections), phase contrast microscopy (at the level of isolated smooth muscle cells), and tensiometry (at the level of smooth muscle strips or the whole gall-bladder). At a very early stage, cholesterol gallstone disease is characterized by exposure of the gall-bladder wall to excess of biliary cholesterol and the cytotoxic effect of the bile salt deoxycholate. On a long-term basis, a form of gall-bladder leiomyopathy develops with defects involving the mechanisms of signal transduction at the level of plasmamembranes. The end-stage result is pathological contraction and/or relaxation of smooth musculature, impaired gall-bladder motility and gall-bladder stasis, all key factors in the pathogenesis of biliary cholesterol crystallization and gallstones.

Published
2000

33. Gallbladder motility and cholesterol crystallization in bile from patients with pigment and cholesterol gallstones

Author

P, Portincasa, A, Di Ciaula, G, Vendemiale, V, Palmieri, A, Moschetta, G P, Vanberge-Henegouwen, and G, Palasciano

Subjects
Adult, Male, Gallbladder, Muscle, Smooth, Fasting, Middle Aged, Postprandial Period, Lipids, Cholesterol, Cholelithiasis, Reference Values, Bile, Humans, Cholecystectomy, Female, Bile Pigments, Crystallization, Aged, Ultrasonography
Abstract

Little is known about gallbladder motility in patients with black pigment stones when compared to cholesterol gallstone patients, or about their relationship to biliary composition, crystallization and stone characteristics.Fasting and postprandial gallbladder volumes were studied by ultrasonography in 49 gallstone patients with pigment (n = 14) or cholesterol (n = 35) stones and 30 healthy controls. After cholecystectomy stone composition, gallbladder wall inflammation, cholesterol saturation index and appearance of platelike cholesterol crystals in bile were evaluated in gallstone patients.Fasting gallbladder volume was significantly (P0.05) increased in cholesterol stone patients (31.7 +/- 1.9 mL) but not in pigment stone patients (21.9 +/- 3.1 mL), compared to controls (21.0 +/- 1.5 mL). Postprandial emptying was delayed in patients (half-emptying time: 31 +/- 2 min, 35 +/- 3 min, 24 +/- 2 min in cholesterol stone patients, pigment stone patients and controls, respectively, P0.05) and incomplete (residual volume: 43.2 +/- 2.7%, 40.0 +/- 4.3%, 15.8 +/- 1.6% min in cholesterol stone patients, pigment stone patients and controls, respectively, P0.05). The inflammation of the gallbladder wall was mild or absent in all cases. Biliary cholesterol saturation index was 152.3 +/- 8.5% and 92.9 +/- 4.8% in patients with cholesterol and pigment stones, respectively (P0.01). Whereas cholesterol crystals never appeared during 21 days in biles from patients with pigment stones, crystal observation time in patients with cholesterol gallstone was 5 days (median) and was significantly shorter in patients with multiple (4 days) than in patients with solitary (12 days) cholesterol stones (P = 0.0019).Patients with black pigment stones who do not have excess cholesterol and do not grow cholesterol crystals in bile have decreased gallbladder emptying, although to a lesser extent than patients with cholesterol stones. Thus, gallbladder stasis is likely to put a subset of subjects at risk for the formation of pigment gallstones, and pathogenic mechanisms need to be further investigated.

Published
2000

35. [Short bowel syndrome]

Author

N, Calomino, M, Malerba, G, Oliva, G, Palasciano, and F, Salvestrini

Subjects
Aged, 80 and over, Short Bowel Syndrome, Parenteral Nutrition, Enteral Nutrition, Humans, Aged
Abstract

In the last year at the Department of Surgery of the University of Siena two patients presenting a clinical feature of intestinal infarct have been operated. In these patients a wide intestinal resection has been performed. After this surgical operation, a patient had a residual tract of 40 cm of bowel and the other 50 cm. It was not possible during operation to preserve the Bauin valve in a case; in the other, this valve has been sacrificed during a previous operation for cecal neoplasm. In the postoperative period, patients were transferred temporarily in the intensive care unit, and after some days they returned to the department where total parenteral nutrition with progressive decreasing mixture in calories over time was administered. Enteral nutrition was also started and the quantity of water, calories and azote was slavly increased. In a second time an oral diet was started up to completely weaning from parenteral and then enteral nutrition. At present, these patients are enlisted in quarterly follow-up and are completely stabilized. They are independent from artificial nutrition and they have a good quality of life.

Published
1999

36. [Short bowel syndrome. Still a current problem]

Author

N, Calomino, M, Malerba, G, Oliva, G, Palasciano, A, Cappelli, F, Salvestrini, and G, Tanzini

Subjects
Aged, 80 and over, Intestines, Male, Postoperative Care, Short Bowel Syndrome, Parenteral Nutrition, Ischemia, Colonic Neoplasms, Humans, Parenteral Nutrition, Total, Colectomy, Aged
Abstract

In the last year the Authors operated two patients presenting with a clinical feature of intestinal infarct. A wide intestinal resection was performed and patients had a residual tract of 40 cm and 50 cm of bowel respectively, later manifesting as short bowel syndrome. It was not possible during the operation to preserve the Baubin valve in one case, in the other one the value had been sacrificed during a previous operation for right colonic malignancy. In the postoperative period, patients were temporarily transferred to the intensive care unit, returning in the surgery ward after few days, and counting total parenteral nutrition with progressive decreasing mixture in calories. Contemporarly enteral nutrition was started slowly increasing the quantity of water, calories and azote administration. In a second time oral diet was started up to completely weaning parenteral and enteral nutrition. At the present patients are enlisted in quarterly follow-up, completely stabilized, and independent from artificial nutrition with a good quality of life. Furthermore a saving of sanitary costs was obtained.

Published
1997

37. An update on the pathogenesis and treatment of cholesterol gallstones

Author

P, Portincasa, P, van de Meeberg, K J, van Erpecum, G, Palasciano, and G P, VanBerge-Henegouwen

Subjects
Cholesterol, Cholelithiasis, Gallbladder, Humans, Gastrointestinal Transit
Abstract

The primum movens in cholesterol gallstone formation is hepatic cholesterol hypersecretion and chronic supersaturation of bile. A cascade of events will then include: (i) multiple biochemical defects: increased total biliary proteins (and qualitative shift to cholesterol crystallization-promoting factors), increased proportions of hydrophobic bile salts, increased mucin secretion, and rapid nucleation/crystallization of cholesterol from cholesterol-enriched biliary vesicles; (ii) multiple motility defects: impaired gallbladder contractility in vitro and gallbladder stasis in vivo, delayed intestinal transit. A genetic predisposition (together with environmental factors) might also be important. Therapy should be offered to patients with symptomatic gallstones. Cholecystectomy remains the only radical therapy for cholelithiasis. For a subgroup of patients with symptomatic, uncomplicated cholesterol stones who are unwilling to undergo surgery, or who have a significant surgical risk, alternative non-invasive therapies include: (i) oral litholysis of small stones by bile salts, (ii) fragmentation of 1-3 medium-sized stones by extracorporeal shock-wave lithotripsy, and (iii) topical dissolution of multiple stones by methyl tertbutyl ether. A major disadvantage of all non-surgical therapies, however, is the 50% recurrence rate of stones at 5 years. A number of prokinetic agents can improve gallbladder and/or intestine transit, two important contributing factors in gallstone disease. In selected patients, administration of these agents might enhance the clearance of cholesterol crystals/gallstones or might impede/delay gallstone formation and recurrence.

Published
1997

38. [Renal peripelvic multicystic lymphangiectasia: is echographic diagnosis possible?]

Author

M, Battaglia, P, Ditonno, G, Carrieri, G A, Saracino, G, Palasciano, P, Martino, and F P, Selvaggi

Subjects
Diagnosis, Differential, Polycystic Kidney Diseases, Lymphangiectasis, Humans, Hydronephrosis, Ultrasonography
Abstract

We describe the role of US, in the diagnosis of LMPR and in differentiating LMPR from other renal disease, such as hydronephrosis and parapelvic cysts. In 10 patients mild to moderate hydronephrosis showed at the US, bilateral in 8 cases, was not confirmed at IVP and CT scan evaluation. Instead, compression of the collecting system by multiple cysts arising from the renal sinus was revealed by CT scan in 8 cases and by IVP in 2. At the U.S. the profile of the calices appeared irregular, differing from the features of hydronephrosis; furthermore calices were adjacent each other, separated only by a thin membrane. All patients were asymptomatic. The examination of the cystic liquor and wall, obtained percutaneously or during surgical procedures, showed the lymphatic origin of them. We cannot provide definitive data regarding how to differentiate LMPR from hydronephrosis at U.S.. In asymptomatic patients the U.S. evidence of dilated calices with irregular profile and thin membrane separating each other, can strongly suggest the diagnosis of LMPR.

Published
1996

39. Tauroursodeoxycholic acid, ursodeoxycholic acid and gallbladder motility in gallstone patients and healthy subjects

Author

P, Portincasa, A, DiCiaula, V, Palmieri, A, Velardi, G P, Van Berge-Henegouwen, and G, Palasciano

Subjects
Adult, Male, Gallbladder Emptying, Time Factors, Ursodeoxycholic Acid, Gallbladder, Postprandial Period, Taurochenodeoxycholic Acid, Gastrointestinal Agents, Isomerism, Cholelithiasis, Case-Control Studies, Humans, Female
Abstract

Fasting and postprandial gallbladder volumes have been measured by sonography both in healthy subjects and gallstone patients ingesting: (a) tauroursodeoxycholic acid; (b) ursodeoxycholic acid; (c) placebo. Each bile salt was given at a dose of 10 mg kg-1. Sonography was repeated in gallstone patients fed tauroursodeoxycholic acid or ursodeoxycholic acid (10 mg kg-1 day-1) for 1 month. Gallstone patients had gallbladder stasis (increase in fasting and residual volumes) and decreased postprandial emptying. Acute ingestion of tauroursodeoxycholic acid or ursodeoxycholic acid did not modify postprandial gallbladder emptying in both groups of subjects. After one month's therapy with tauroursodeoxycholic acid or ursodeoxycholic acid, fasting gallbladder volume further increased in gallstone patients, although gallbladder emptying remained unchanged. Thus, therapeutic doses of tauroursodeoxycholic acid or ursodeoxycholic acid do not acutely modify postprandial gallbladder emptying in either healthy subjects or gallstone patients. Chronic treatment with either bile salts results in an increase in fasting gallbladder volume without interfering with the extent of postprandial gallbladder emptying.

Published
1996

40. Enhancement of gallbladder emptying in gallstone patients after oral cholestyramine

Author

P, Portincasa, A, Di Ciaula, V O, Palmieri, G, Baldassarre, and G, Palasciano

Subjects
Adult, Aged, 80 and over, Male, Gallbladder Emptying, Cholelithiasis, Cholestyramine Resin, Administration, Oral, Humans, Female, Middle Aged, Aged
Abstract

To evaluate whether a low dose of oral cholestyramine improves gallbladder emptying in gallstone patients.Gallbladder volumes were assessed by sonography in 36 patients with cholesterol gallstones and 18 healthy controls. On three different days subjects ingested: 1) test meal alone, 2) test meal plus cholestyramine (4 g), and 3) cholestyramine alone (4 g).Fasting gallbladder volume (mean +/- SE, 25.9 +/- 1.8 ml and 19.2 +/- 1.3 ml for patients and controls, respectively, p0.05) and postprandial gallbladder residual volume (48.7 +/- 3.9% and 21.6 +/- 2.8% of fasting volume in patients and controls, respectively, p0.001) were larger in patients than controls, indicating impaired gallbladder emptying. Gallstone patients were divided into 19 "contractors" and 17 "hypocontractors" (residual gallbladder volume smaller or greater than mean +/- 2 SD of controls). Compared with the test meal alone, the addition of cholestyramine induced a further decrease of residual volume in contractors (from 30.4 +/- 2.1% to 19.8 +/- 1.9%, p0.001), hypocontractors (from 69.3 +/- 3.9% to 56.7 +/- 7.4%, p0.05), and controls (from 21.6 +/- 2.8% to 5.0 +/- 1.0%, p0.0004). Two hours after test meal plus cholestyramine gallbladder volume was still markedly reduced in both patients and controls. Fasting gallbladder volume 24 h after test meal plus cholestyramine was decreased in patients and in controls. The ingestion of cholestyramine alone initiated gallbladder evacuation comparable to that of test meal in both contractors and hypocontractors.A low dose of cholestyramine in combination with test meal induces a considerable decrement of gallbladder volume compared with test meal alone in gallstone patients. Cholestyramine alone causes a decrease of gallbladder volume which is comparable to that observed in response to test meal alone.

Published
1994

41. Sonographic evaluation of gallstone burden in humans

Author

P, Portincasa, A, Di Ciaula, V, Palmieri, G, Vendemiale, E, Altomare, and G, Palasciano

Subjects
Male, Cholelithiasis, Humans, Cholecystectomy, Female, Prospective Studies, Middle Aged, Algorithms, Ultrasonography
Abstract

A prospective blind study was performed to compare sonographic with postoperative findings of gallstone burden in 34 patients (10 males, 24 females; mean age 52 years). Gallstone size was assessed in single calculi (n = 15) by measuring the largest diameter by ultrasonography (US). The ellipsoid algorithm was used to estimate US volume for both single and multiple gallstones. After cholecystectomy, diameters were measured in single stones; stone volume was assessed by the ellipsoid formula (single stones) and fluid displacement (single and multiple stones). Stone volumes assessed by the ellipsoid formula and fluid displacement correlated closely (r = 0.98; p0.0001, n = 15). In the case of single gallstones, the mean length assessed by US was 25.3 +/- 3.2 mm and compared well with the value measured "in vitro" (24.8 +/- 3.1 mm). A highly significant and positive relationship existed between the sonographic size and the true stone size (r = 0.93; p0.0001, n = 15). Stone volumes assessed "in vivo" and by fluid displacement were comparable and correlated for both single (US: 6.6 +/- 1.3 vs fluid displacement: 5.8 +/- 1.4 ml; r = 0.79; p0.0005, n = 15) and multiple stones (US: 3.8 +/- 0.8 vs fluid displacement: 3.7 +/- 0.8 ml; r = 0.85; p0.0001, n = 19).(ABSTRACT TRUNCATED AT 250 WORDS)

Published
1994

43. Crystalline lactulose in the therapy of hepatic cirrhosis. Evaluation of clinical and immunological parameters. Preliminary results

Author

G, Vendemiale, G, Palasciano, F, Cirelli, M, Altamura, A, De Vincentiis, and E, Altomare

Subjects
Adult, Liver Cirrhosis, Male, Blood Bactericidal Activity, Suspensions, Ammonia, Humans, Bilirubin, Female, Middle Aged, Crystallization, Lactulose, Aged
Abstract

Crystalline lactulose (Laevolac Cristalli, CAS 4618-18-2), a pure form of the disaccharide widely employed in the therapy of complications of liver cirrhosis, was administered, after a pharmacological wash-out of 10 days and following a randomized design, to 10 cirrhotic patients for 30 days at the dosage of 60 g/d, while another 10 subjects with similar characteristics received no treatment. Besides the parameters usually monitored for the evaluation of liver function and state of hepatic encephalopathy, immunological patterns such as lymphocyte subpopulations CD3, CD4, CD8, CD16(NK), CD25 and antibacterial activity against Ty2 strain of Salmonella typhi were evaluated. At the end of the study (day 30) a significant decrease of blood ammonia was observed, as expected, only in the group treated with lactulose with respect to the control group, as well as a significant increase of CD16 and antibacterial activity (1/3); an enhanced level of CD25, although not significant, was also noticed in the treated group with respect to the control group. These findings seem to show an effect of activation on cell-mediated immune system depressed during liver cirrhosis, produced by lactulose. Further studies are needed to confirm these data and to clarify the possible mechanisms involved.

Published
1992

44. Gallbladder volume in adults, and relationship to age, sex, body mass index, and gallstones: a sonographic population study

Author

G, Palasciano, G, Serio, P, Portincasa, V, Palmieri, M, Fanelli, A, Velardi, B, Calo' Gabrieli, and V, Vinciguerra

Subjects
Adult, Male, Aging, Sex Characteristics, Gallbladder, Fasting, Middle Aged, Body Mass Index, Cholelithiasis, Humans, Female, Obesity, Aged, Ultrasonography
Abstract

The influence of gender, age, body size, cholelithiasis, and obesity on fasting gallbladder volume (GBV) was investigated by real-time ultrasonography in a general population cohort of subjects whose ages were between 30 and 69 yr, living in Bari, a Southeastern Italian city. Of the 2076 subjects analyzed, 1246 (60%) were males and 830 (40%) were females (mean age 50 yr). Among them, 1703 subjects were healthy, 108 had gallstones, and 265 were obese. Fasting GBV in healthy individuals was larger in males (M) than in females (F) [M, 18.7 +/- 0.3 (SEM) ml vs. F, 17.0 +/- 0.3 ml; p less than 0.001] and obese (M, 23.4 +/- 1.5 ml vs. 19.7 +/- 0.9 ml; p less than 0.05). The trend was similar in gallstone patients, but it was not statistically significant (M, 23.0 +/- 2.0 ml vs. F, 18.8 +/- 1.5 ml; t = 1.64). Gallbladder size correlated positively with body size in the lean healthy population (p less than 0.01), increased with age in healthy nonobese males (p less than 0.01), and was smaller in healthy males than in males with gallstones (0.01 less than p less than 0.02) and obese, in both sexes (p less than 0.01). We conclude that fasting GBV 1) is larger in lean healthy and obese males than females, 2) increases with age in lean males and with body size in healthy lean females, and 3) is greater in patients with gallstones and in obese subjects, and this might partially account for the defective gallbladder motor function reported in these patients.

Published
1992

45. The effect of the H2-antagonist niperotidine on intragastric acidity in healthy subjects undergoing 24-hour pH-monitoring

Author

G, Palasciano, V, Maggi, and P, Portincasa

Subjects
Adult, Male, Time Factors, Dioxoles, Gastric Acidity Determination, Hydrogen-Ion Concentration, Middle Aged, Gastric Acid, Placebos, Eating, Double-Blind Method, Histamine H2 Antagonists, Humans, Female, Furans, Monitoring, Physiologic
Abstract

The effects of niperotidine, a novel histamine H2-receptor antagonist, on nocturnal gastric acid secretion in healthy volunteers, have been investigated. Twenty subjects were randomly assigned to the placebo (M:F = 7:3; Age 34 +/- SD3 yrs) or to the niperotidine-treated group (M:F = 7:3; Age: 37 +/- 6 yrs) in which 460 mg were administered at 22.00. Intragastric acidity was assessed by means of 24-hour pH-measurement (10.00-22.00) using sensitive antimony monocrystalline electrodes. The percentage of daytime gastric acidity (prandial and interprandial) was similar in both groups (median; interquartile range): placebo group 87.5; 69.5-90.1 vs niperotidine 85.8; 59-89.1. Niperotidine increased the intragastric pH during the period 22.00-10.00. The percentage of time above pH 4 was higher in the treated group (28.4; 14.8-50.7% vs 7.4; 1.4-10.7%; p less than 0.02). The duration of niperotidine action was 5 to 7 hours. The nocturnal pH frequency curve after niperotidine was shifted toward alkaline values with a decrease of acidity in the pH range 1-2 (p less than 0.04). We conclude that a bedtime dose of niperotidine inhibits nocturnal gastric acid secretion in healthy subjects.

Published
1990

46. The effect of a novel CCK-antagonist (lorglumide) on human and guinea pig gallbladder strips: a tensiometric study

Author

P, Portincasa, R, Brandonisio, A, Di Ciaula, V, Maggi, M, Chiloiro, and G, Palasciano

Subjects
Adult, Male, Dose-Response Relationship, Drug, Guinea Pigs, Gallbladder, Muscle, Smooth, Middle Aged, Sincalide, Proglumide, Species Specificity, Animals, Humans, Receptors, Cholecystokinin, Aged, Muscle Contraction
Abstract

The effect of a novel CCK-antagonist (lorglumide, CR 1409) was evaluated by "in vitro" tensiometric studies on 16 human (gallstone patients) and 12 guinea pig gallbladder smooth muscle strips. In the animal experiments, increasing doses of lorglumide (0.2-6.5 uM) caused a rightward shift of the dose-response curves of CCK-OP, with an increase of the ED50 from 8.2 nM +/- 1.62 SEM, n = 12; to 100 nM +/- 12, n = 4) without affecting the maximal effect (Emax). Schild plot gave an affinity constant of 7.19. In human gallbladders, the effect of lorglumide was also present (ED50 increased from 47 nM +/- 8 SEM, n = 16; to 300 nM +/- 10 SEM, n = 4) coexisting with a large inter-sample variation for CCK-OP ED50s and maximal contractions, most likely due to the histological changes of the wall in chronic cholecystitis. The affinity constant was similar to that found in animal experiments. We confirm the studies previously reported in animals on the existence of a competitive antagonism of lorglumide on CCK gallbladder receptors. Moreover, our results on gallbladders from gallstone patients show that lorglumide is a highly effective antagonist of CCK-induced contractions despite the presence of chronic cholecystitis. Our study might help for a better comprehension of the role of these new anti-CCK drugs in the treatment of biliary pain.

Published
1990

47. Isolation and functional characterization of rat pancreatic acini

Author

V O, Palmieri, A, Velardi, N, Morelli, P, Portincasa, D, Patimo, and G, Palasciano

Subjects
Male, Amylases, Animals, Carbachol, Cell Separation, Pancreas, Sincalide, Rats
Abstract

The Authors describe an optimized procedure for the isolation of rat pancreatic acini and the preliminary results concerning the functional characterization of the cells. Isolation is carried out by two sequential digestive steps in a KREBS modified medium containing collagenase, separated by an intermediate step in which acini separation is fostered by incubation in a Ca++ free medium containing the Ca++ chelator EDTA. Final separation is obtained through the application of mechanical forces by aspirating the suspension in plastic pipettes. The choice of the collagenase, the duration and the entity of the mechanical dissociation strength are the main modifications to the classic procedure and allow to obtain a very high yield of cells maintaining their ability to secrete enzymes for a long period (6-7 hours). Functional characterization is completed mainly by the determination of the amylase release stimulated by increasing doses of cholecystokinin.

Published
1990

48. Fluorimetric study of intracellular Ca++ homeostasis in isolated rat pancreatic acini

Author

V O, Palmieri, A, Velardi, N, Morelli, M, Tomanelli, V, Maggi, and G, Palasciano

Subjects
Intracellular Fluid, Animals, Homeostasis, Calcium, Carbachol, Fluorometry, Rats, Inbred Strains, Cholecystokinin, Fura-2, Pancreas, Rats
Abstract

A fluorimetric method for the study of intracellular Ca++ metabolism in rat pancreatic acini is described. Following previous reports on the utilization of the new intracellularly trapped fluorescent dye fura2 in human lymphocytes, the authors point out the relevance of the cellular and fura2 concentration as critical issues for an accurate evaluation of Ca++ homeostasis. A dose-response curve to both carbamoylcholine and cholecystokinin is reported, demonstrating the ability of the cells to respond to hormonal stimulation with a transient Ca++ peak. The almost complete absence of noise in the recorded traces allow to carry out an evaluation of the intracellular mechanism related to Ca++ mobilization with a very high sensitivity.

Published
1990

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