27 results on '"G, Di Bartolomeo"'
Search Results
2. CORTESIA E SCELTE COLLETTIVE
- Author
-
G. DI BARTOLOMEO, PAPA S, Giovanni Di Bartolomeo e Stefano Papa, A. Bianchi, M. De Nicola, G. Di Bartolomeo, P. Di Giovanni, S. Papa, O. Trio, G., DI BARTOLOMEO, and Papa, S
- Subjects
Settore SECS-P/01 - Published
- 2008
3. Emergency response of Italian geologists to recent natural disasters
- Author
-
G. V. Graziano, C. Cencetti, G. Di Bartolomeo, CALCATERRA, DOMENICO, G. V., Graziano, Calcaterra, Domenico, C., Cencetti, and G., Di Bartolomeo
- Subjects
Emergency phase ,Geological risk ,Italian Geologists - Published
- 2011
4. [Untitled]
- Author
-
G. Di Bartolomeo, Jacob Engwerda, B. van Aarle, and Joseph Plasmans
- Subjects
Macroeconomics ,Economics and Econometrics ,Stylized fact ,Monetarism ,Policy making ,European integration ,Economics ,media_common.cataloged_instance ,European union ,Monetary hegemony ,Fiscal union ,Fiscal policy ,media_common - Abstract
The interaction of monetary and fiscal policies is a crucial issue in a highly integrated economic area such as the European Union. This paper analyzes the design of monetary and fiscal policies in the EMU. To do so, the paper starts with an overview of the most important aspects. Next, it analyzes monetary and fiscal policy interaction in a stylized model of a monetary union, in which monetary and fiscal policy design is modeled as a dynamic stabilization game. Macroeconomic policy making and adjustment are studied under alternative forms of cooperation and in both symmetric and asymmetric settings.
- Published
- 2002
5. Controllability in policy games: Policy neutrality and the theory of economic policy revisited
- Author
-
G. Di Bartolomeo, N Acocella, and Andrew Hughes Hallett
- Subjects
Controllability ,Policy studies ,Generalization ,Economic policy ,Economics, Econometrics and Finance (miscellaneous) ,Monetary policy ,LQ-policy games - policy neutrality - policy effectiveness - controllability - Tinbergen system ,Economics ,Context (language use) ,Neutrality ,Policy analysis ,Computer Science Applications ,Policy effectiveness - Abstract
Issues of policy effectiveness and policy neutrality are widespread in the economic literature. They have been raised in a number of specific contexts over the past 20 years, most notably with reference to monetary policy. However, the general conditions which ensure the non-neutrality of any or all the policy instruments available to a policymaker in a strategic context still remain to be derived. To do that, this paper provides a generalization of the classical theory of economic policy developed by Tinbergen, Theil and others to a strategic environment. Computational algorithms, so that neutrality and controllability can be tested in practice, are given. We show that many of the standard policy neutrality propositions of monetary theory and in wage bargaining models then drop out as special cases of our encompassing approach but with much simpler interpretations.
- Published
- 2006
6. Tinbergen and Theil Meet Nash: Controllability in Policy Games
- Author
-
Nicola Acocella and G. Di Bartolomeo
- Subjects
TheoryofComputation_MISCELLANEOUS ,Policy ineffectiveness ,Economics and Econometrics ,Policy games ,Static controllability ,Nash equilibrium existence ,jel:E61 ,Context (language use) ,Policy games, policy ineffectiveness, static controllability, Nash equilibrium existence ,Microeconomics ,symbols.namesake ,Economics ,Price of stability ,Classical theory ,jel:C72 ,TheoryofComputation_GENERAL ,jel:E52 ,Controllability ,Nash equilibrium ,Best response ,symbols ,Epsilon-equilibrium ,Mathematical economics ,Finance - Abstract
This paper generalizes the classical theory of economic policy developed by Tinbergen and Theil to a static LQ-strategic context between n players. We show how this generalized version of controllability can profitably be used to deal with policy ineffectiveness issues and Nash equilibrium existence.
- Published
- 2005
7. Coalitional behavior in an open-loop LQ-differential game for the EMU
- Author
-
Joseph Plasmans, G. Di Bartolomeo, B. van Aarle, and Jacob Engwerda
- Subjects
Microeconomics ,Bargaining power ,Price stabilization ,business.industry ,European central bank ,Differential game ,Open-loop controller ,Economics ,Distribution (economics) ,business ,Enforcement - Abstract
Publisher Summary This chapter discusses the coalitional behavior in an open-loop LQ-differential game for the EMU. The interaction of monetary and fiscal policies is a crucial issue in a highly integrated economic area like the EU. It is shown that when the coalition formation game is played without communication among the policy-makers, cooperation is either impossible or limited. In the simulation, the focus is on the priorities and bargaining power distribution of the policy-makers. It is assumed that both governments' priority is real output stabilization while the European Central Bank is mainly concerned about price stabilization. It is found that when the policy-makers can communicate, full cooperation becomes possible in equilibrium, whereas complete noncooperation is not sustainable in equilibrium. This contrast provides broad support for the view that institutions and international forums for discussion can play a crucial role in achieving international cooperation, even when these institutions are not endowed with enforcement powers.
- Published
- 2003
8. Coalitional behavior in an open-loop LQ-differential game for the EMU
- Author
-
B. van Aarle, G. Di Bartolomeo, Joseph Plasmans, and Jacob Engwerda
- Subjects
Microeconomics ,Focus (computing) ,Public economics ,Differential game ,Open-loop controller ,Economics ,TheoryofComputation_GENERAL ,ComputingMilieux_LEGALASPECTSOFCOMPUTING ,Institutional Shifts in Government and Governance in a Comparative and International Context - Abstract
Item does not contain fulltext The EMU is an highly integrated economic area where externalities occur. Therefore, in this context interaction of monetary and fiscal policies is a crucial issue. This paper fo-cuses on how coalitions among policy-makers are formed and what are their effects on the stabilization of output and price. We emphasize the role played by the institutional design of "cooperation forums" (as, e.g., the ECOFIN). If the coalition formation game is played without communication among the policy-makers full cooperation is either impossible or limited. On the other hand, if policy-makers can communicate, full cooperation becomes a possible equilibrium, while the complete non-cooperative solution is, in general, not a sustainable equilibrium. This contrast begins to provide broad support for the view that in-stitutions and international forums for discussions can play a crucial role in achieving in-ternational cooperation even when these institutions are not endowed with enforcement powers. 24 p.
- Published
- 2001
9. Density gradient separation of hematopoietic stem cells in autologous bone marrow transplantation
- Author
-
A, Iacone, A M, Quaglietta, D, D'Antonio, P, Accorsi, A, Dragani, F, Angrilli, A, Berardi, A, Angelini, P, Di Bartolomeo, and G, Di Bartolomeo
- Subjects
Leukemia ,Lymphoma ,Hematopoietic Stem Cell Transplantation ,Cell Separation ,Hematopoietic Stem Cells ,Transplantation, Autologous ,Cryoprotective Agents ,Centrifugation, Density Gradient ,Neoplastic Stem Cells ,Ficoll ,Humans ,Dimethyl Sulfoxide ,Cyclophosphamide ,Bone Marrow Transplantation - Abstract
Recently, the principles of density gradient cell separation have been transferred to the marrow fractionation, and the Ficoll technique by using a COBE 2991 blood cell processor has been developed and widely employed as well. This method is particularly useful in view of a chemical antineoplastic purging intended for autologous marrow transplantation. Forty marrows, which derived from patients suffering with leukemia and lymphoma, were fractionated with Ficoll on a COBE machine and in vitro purged with Mafosfamide at a dose of 50 micrograms/ml/1 x 10e7 MN cells. The density gradient separation enables to reduce the initial volume to 10%, the contaminating RBC to less than 1%, the total nucleated cells to 25% (greater than 80% of MNC) sparing about 80% of the CFU-GM. After purging, the surviving hemopoietic progenitor cells were 2.5%. The clinical effects of the fractionated purged cells were studied in 11 autotransplanted patients and compared with 14 transplants performed with untreated buffy-coat marrow derived cells. Ficoll cells produced less adverse effects at the time of reinfusion, while, as expected, the time of hematopoietic recovery was delayed in these patients (mafosfamide treated cells). These results confirm the usefulness of the gradient density cell separation to reduce the side effects of the DMSO and to make reliable the Mafosfamide purging manoeuvre, preventing the interference of contaminating RBC aldehyde dehydrogenase.
- Published
- 1991
10. Infection after autologous blood-derived stem cell transplantation
- Author
-
D, D'Antonio, A, Iacone, G, Fioritoni, A, Angelini, A, Dragani, S, Betti, P, Di Bartolomeo, G, Di Bartolomeo, P, Accorsi, and A M, Quaglietta
- Subjects
Adult ,Male ,Blood Transfusion, Autologous ,Adolescent ,Hematopoietic Stem Cell Transplantation ,Humans ,Female ,Middle Aged ,Infections ,Retrospective Studies - Abstract
Ten patients who underwent autologous blood-derived stem cell transplantation (APBSCT) were studied retrospectively to determine the frequency and outcome of transplant associated infections during the hemopoietic reconstitution. Six patients developed an infection after transplant. Severe bacterial infections were unfrequent and mostly caused by gram-positive cocci. In no case pneumonia was observed and this scarce morbility of infection could be the result of early engraftment. None of them died for infection. The frequency of infections in APBSCT patients appears lower than the one observed in autologous bone marrow transplant patients.
- Published
- 1990
11. Collection of peripheral blood stem cells in normal donors
- Author
-
A, Iacone, A M, Quaglietta, A, Dragani, A, Berardi, G, Di Bartolomeo, P, Accorsi, and P, Colamartino
- Subjects
Plateletpheresis ,Blood Component Removal ,Humans ,Blood Donors ,Cell Separation ,Hematopoietic Stem Cells ,Specimen Handling - Abstract
Although committed progenitor cells have been harvested during the standard plateletpheresis, only few experiences were specifically carried out in normal donors. The major drawback is the very low number of circulating haemopoietic stem cells and, besides a donor manipulation, a good harvesting technology is a fundamental prerequisite. To verify the effectiveness of an automate system, twenty normal volunteer donors were randomly assigned to four protocols of simultaneous PBSC and platelet collection. A Baxter separator CS 3000 was employed and we compared the yields and the efficiency of the modified Program 1 plus isoradial chamber (Protocol A), the modified Program 1 plus granulo chamber (Protocol B), the standard Program 3 plus isoradial chamber (Protocol C) and the standard Program 3 plus granulo chamber (Protocol D). The absolute yields for WBC (x10(9)), MNC (x10(9)), platelets (x10(11)) and CFU-GM (x10(4)) were respectively: 10.4, 10.1, 6.5 and 29.5 for Protocol A; 10.1, 9.9, 5.2 and 14.7 for Protocol B; 10.0, 9.9, 5.2, 14.7 for Protocol C, and 12.7, 12.4, 6.8 and 57.4 for Protocol D. The best CFU-GM efficiency was achieved with Protocol D (33%) vs. Protocol A (27.5%), Protocol B (14.5%) and Protocol C (27%). The above differences, although remarkable, were not statistically significant. Though preliminary, this study demonstrates the feasibility of a combined platelet and PBSC collection in normal donors.
- Published
- 1990
12. Pharmacological mobilization of haemopoietic progenitor cells in human peripheral blood
- Author
-
A, Berardi, L, Geraci, A M, Quaglietta, G, Di Bartolomeo, and A, Dragani
- Subjects
Adult ,Male ,Leucovorin ,Humans ,Prednisone ,Female ,Hematopoietic Stem Cells - Abstract
We investigated Prednisone (PRD) and Folinic Acid (FA) ability to recruit stem cells (CFU-S) into the circulating compartment, evaluating CFU-GM, BFU-E and CFU-GEMM count increases in peripheral blood (PB). Fifteen healthy donors were administered 75 mg PRD in one trial, and 15 mg FA p.o. through 5 consecutive days in another trial. We observed a significant expansion for BFU-E and CFU-GEMM compartments, though not parallelled by CFU-GM expansion. FA determined a significant increase in CFU-GM on the 5th day of administration, as well as in BFU-E on day 7. It fails to raise CFU-GEMM. The authors suggest a less empiric persuing for such attempts to optimize the use of non-chemotherapic drugs to recruit hemopoietic precursors into PB, so that these can suit to meet stem cell needs for autologous and allogeneic transplantations.
- Published
- 1990
13. [Electrocardiographic changes after resection of postinfarction left ventricular aneurysm]
- Author
-
L, Frabetti, C, Rapezzi, A, Capucci, M, Ferlito, G, Di Bartolomeo, and B, Magnani
- Subjects
Adult ,Heart Septal Defects, Ventricular ,Male ,Heart Ventricles ,Myocardial Infarction ,Arrhythmias, Cardiac ,Middle Aged ,Angina Pectoris ,Electrocardiography ,Heart Block ,Humans ,Female ,Heart Aneurysm ,Aged - Published
- 1982
14. Il rendimento scolastico: un’analisi dell’indagine PISA
- Author
-
Gabrielli G., Di Bartolomeo A., Gabrielli G., Di Bartolomeo A., De Santis G., Pirani E., Porcu M., Gabrielli, G., and Di Bartolomeo, A.
- Subjects
Scuola, indagine PISA, risultati scolastici - Abstract
Il libro affronta il complesso tema dell’istruzione sotto vari profili: come è organizzata in Italia, come è cambiata nel recente passato e come cambierà in futuro. Si analizzano in particolare gli aspetti problematici relativi alle risorse (come vengono investite e da parte di chi, nel settore pubblico e in quello privato), la valutazione dei risultati, la presenza degli stranieri, il trattamento di aspetti differenziali, la capacità della scuola di favorire la mobilità sociale e la sua utilità come investimento economico per le famiglie e gli individui.
- Published
- 2019
15. Sutureless and Rapid-Deployment Aortic Valve Replacement International Registry (SURD-IR): early results from 3343 patients
- Author
-
Tristan D. Yan, Kevin Phan, Kevin Teoh, Marco Di Eusanio, Gianluca Martinelli, Thierry Folliguet, Roberto Di Bartolomeo, Mattia Glauber, Carmelo Mignosa, Paolo Berretta, Malak Shrestha, Marco Solinas, Giuseppe Santarpino, Martin Misfeld, Bart Meuris, Alberto Albertini, Thierry Carrel, Utz Kappert, Emmanuel Villa, Martin Andreas, and Di Eusanio M, Phan K, Berretta P, Carrel TP, Andreas M, Santarpino G, Di Bartolomeo R, Folliguet T, Meuris B, Mignosa C, Martinelli G, Misfeld M, Glauber M, Kappert U, Shrestha M, Albertini A, Teoh K, Villa E, Yan T, Solinas M
- Subjects
Pulmonary and Respiratory Medicine ,Aortic valve ,Adult ,Male ,medicine.medical_specialty ,Canada ,Time Factors ,610 Medicine & health ,030204 cardiovascular system & hematology ,Prosthesis Design ,03 medical and health sciences ,0302 clinical medicine ,Postoperative Complications ,Aortic valve replacement ,medicine ,Humans ,Hospital Mortality ,Registries ,Aortic valve replacement, Rapid-deployment valve, Sutureless and Rapid-Deployment, Aortic Valve Replacement International Registry, Sutureless valve, The International Valvular Surgery Study Group ,Stroke ,Aged ,Retrospective Studies ,Aged, 80 and over ,business.industry ,Mortality rate ,Incidence (epidemiology) ,Incidence ,Australia ,Retrospective cohort study ,General Medicine ,Aortic Valve Stenosis ,Middle Aged ,medicine.disease ,Sutureless Surgical Procedures ,Surgery ,Europe ,Survival Rate ,medicine.anatomical_structure ,Treatment Outcome ,030228 respiratory system ,Concomitant ,Aortic Valve ,Female ,Cardiology and Cardiovascular Medicine ,business ,Atrioventricular block ,Follow-Up Studies - Abstract
OBJECTIVES The Sutureless and Rapid-Deployment Aortic Valve Replacement International Registry (SURD-IR) was established by a consortium of 18 research centres-the International Valvular Surgery Study Group (IVSSG)-to overcome limitations of the literature and provide adequately powered evidence on sutureless and rapid-deployment aortic valves replacement (SURD-AVR). METHODS Data from 3343 patients undergoing SURD-AVR over a 10-year period (2007-2017) were collected in the registry. The mean age of the patients was 76.8 ± 6.7 years, with 36.4% being 80 years or older. The average logistic EuroSCORE was 11.3 ± 9.7%. RESULTS Isolated SURD-AVR was performed in 70.7% (n = 2362) of patients using full sternotomy (35.3%) or less invasive approaches (64.8%). Overall hospital mortality was 2.1%, being 1.4% in patients who had isolated SURD-AVR and 3.5% in those who had concomitant procedures (P
- Published
- 2017
16. Integration and territorial Dimension
- Author
-
B.L.A.N.G.I.A.R.D.O. G. C., BONIFAZI C., BRACALENTI R., CONTI C., DI SCIULLO L., STROZZA, SALVATORE, Blangiardo G.C., Bonifazi C., Bracalenti R., Conti C., Costa G., Di Bartolomeo A., Di Sciullo L., Mondo L., Rottino F.M., Gabrielli D., Ghio D., Perez M., Quattrociocchi L., Schizzerotto A., Sciortino G., Spadea M.T., Strozza S., Zizza R., ISTAT, B. L. A. N. G. I. A. R. D. O. G., C., Bonifazi, C., Bracalenti, R., Conti, C., DI SCIULLO, L., and Strozza, Salvatore
- Subjects
Micro and macro indicator ,Italy ,Measures and indicators of integration ,Local level of analysi - Abstract
The article discusses the following topics: a) Local integration of immigrants in Italy froma a "macro" perspective: the decade-long research experience of the Cnel; b) Local aspects of integration: account of a "micro" experience; c) The contribution of local councils on immigration for the purposes of assessing levels of integration.
- Published
- 2013
17. Integration and Integration Guides
- Author
-
BONIFAZI C., GABRIELLI D. , SCIORTINO G., STROZZA, SALVATORE, Blangiardo G.C., Bonifazi C., Bracalenti R., Conti C., Costa G., Di Bartolomeo A., Di Sciullo L., Mondo L., Rottino F.M., Gabrielli D., Ghio D., Perez M., Quattrociocchi L., Schizzerotto A., Sciortino G., Spadea M.T., Strozza S., Zizza R., ISTAT, Bonifazi, C., GABRIELLI D., SCIORTINO G., and Strozza, Salvatore
- Subjects
Integration of immigrant ,Measures and indicators ,Sources of data - Abstract
The article analyzes the Italian experience in the field of measuring integration of immigrants: a) The beginnings, the activities of the Commission for the Integration Policies and aggregate indicators; Recent development, national and local surveys and individual indicators.
- Published
- 2013
18. Active Citizenship
- Author
-
BONIFAZI C., CONTI C., GHIO D., ROTTINO F. M., STROZZA, SALVATORE, Blangiardo G.C., Bonifazi C., Bracalenti R., Conti C., Costa G., Di Bartolomeo A., Di Sciullo L., Mondo L., Rottino F.M., Gabrielli D., Ghio D., Perez M., Quattrociocchi L., Schizzerotto A., Sciortino G., Spadea M.T., Strozza S., Zizza R., ISTAT, Bonifazi, C., Conti, C., Ghio, D., Rottino, F. M., and Strozza, Salvatore
- Subjects
Italy ,Statistical source ,Acquisition of citizenship ,Measures and indicator - Abstract
The article discusses the following topics: a) Italian legislation on citizenship and long-term residents; b) Acquisition of citizenship and naturalisation: from the regulation on migration statistics to the Zaragoza Declaration; c) Other indicators of active citizenship: situation and prospects in the case of Italy.
- Published
- 2013
19. Second Generation and Educational Attainment
- Author
-
CONTI C., DI BARTOLOMEO A., ROTTINO F. M., STROZZA, SALVATORE, Blangiardo G.C., Bonifazi C., Bracalenti R., Conti C., Costa G., Di Bartolomeo A., Di Sciullo L., Mondo L., Rottino F.M., Gabrielli D., Ghio D., Perez M., Quattrociocchi L., Schizzerotto A., Sciortino G., Spadea M.T., Strozza S., Zizza R., ISTAT, Conti, C., DI BARTOLOMEO, A., Rottino, F. M., and Strozza, Salvatore
- Subjects
Settore SPS/08 - Sociologia dei Processi Culturali e Comunicativi ,Statistical source ,Second generation ,Settore SPS/07 - Sociologia Generale ,Definition ,Multivariate and multilevel regressions ,Settore SECS-S/05 - Statistica Sociale ,Educational outcomes and achievement ,Measures and indicator ,Settore SECS-S/04 - Demografia - Abstract
The article discusses the following topics: a) Definitional issues of second generation of immigrants; b) From the definitions to the examination of the categories of interest in the main statistical sources; c) Foreign student at school: indicators of educational outcomes and achievement; d) Local and prospective experiences for measuring school inclusion.
- Published
- 2013
20. The Concept of Integration
- Author
-
BONIFAZI C., GABRIELLI D., SCIORTINO G., STROZZA, SALVATORE, Blangiardo G.C., Bonifazi C., Bracalenti R., Conti C., Costa G., Di Bartolomeo A., Di Sciullo L., Mondo L., Rottino F.M., Gabrielli D., Ghio D., Perez M., Quattrociocchi L., Schizzerotto A., Sciortino G., Spadea M.T., Strozza S., Zizza R., ISTAT, Bonifazi, C., Gabrielli, D., Sciortino, G., and Strozza, Salvatore
- Subjects
Integration - Abstract
The article describes the emergence of the concept of integration between North America and Europe
- Published
- 2013
21. Economia della cortesia: il valore economico del rispetto e della considerazione per gli altri Ed. Carocci 2008
- Author
-
Bianchi, A, DE NICOLA, M, DI BARTOLOMEO, G, DI GIOVANNI, P, Papa, S, Trio, O, A., Bianchi, M., DE NICOLA, G., DI BARTOLOMEO, P., DI GIOVANNI, Papa, S, and O., Trio
- Subjects
Settore SECS-P/01 - Published
- 2008
22. The fiscal response to the Italian COVID-19 crisis: A counterfactual analysis.
- Author
-
Di Bartolomeo G, D'Imperio P, and Felici F
- Abstract
The COVID-19 pandemic is an unprecedented worldwide event with a massive impact on the economic system. The first Western country that had to face the COVID-19 crisis was Italy, which therefore represents a natural "case study." By using the microdata and granular policy information available at the Italian Ministry of Economy and Finance, this paper provides a macroeconomic quantitative assessment of the initial emergency fiscal measures introduced in 2020 and an analysis of the impact of the COVID-19 shock during the lockdown. We find that emergency measures avoided an additional fall of GDP of about 4.4% in 2020. The impact of public interventions on the dynamics of investments is particularly significant., (© 2022 Elsevier Inc. All rights reserved.)
- Published
- 2022
- Full Text
- View/download PDF
23. Density gradient separation of hematopoietic stem cells in autologous bone marrow transplantation.
- Author
-
Iacone A, Quaglietta AM, D'Antonio D, Accorsi P, Dragani A, Angrilli F, Berardi A, Angelini A, Di Bartolomeo P, and Di Bartolomeo G
- Subjects
- Bone Marrow Transplantation adverse effects, Cryoprotective Agents adverse effects, Cyclophosphamide analogs & derivatives, Cyclophosphamide pharmacology, Dimethyl Sulfoxide adverse effects, Ficoll, Hematopoietic Stem Cell Transplantation, Humans, Leukemia pathology, Leukemia surgery, Lymphoma pathology, Lymphoma surgery, Neoplastic Stem Cells drug effects, Transplantation, Autologous, Bone Marrow Transplantation methods, Cell Separation instrumentation, Cell Separation methods, Centrifugation, Density Gradient instrumentation, Centrifugation, Density Gradient methods, Hematopoietic Stem Cells
- Abstract
Recently, the principles of density gradient cell separation have been transferred to the marrow fractionation, and the Ficoll technique by using a COBE 2991 blood cell processor has been developed and widely employed as well. This method is particularly useful in view of a chemical antineoplastic purging intended for autologous marrow transplantation. Forty marrows, which derived from patients suffering with leukemia and lymphoma, were fractionated with Ficoll on a COBE machine and in vitro purged with Mafosfamide at a dose of 50 micrograms/ml/1 x 10e7 MN cells. The density gradient separation enables to reduce the initial volume to 10%, the contaminating RBC to less than 1%, the total nucleated cells to 25% (greater than 80% of MNC) sparing about 80% of the CFU-GM. After purging, the surviving hemopoietic progenitor cells were 2.5%. The clinical effects of the fractionated purged cells were studied in 11 autotransplanted patients and compared with 14 transplants performed with untreated buffy-coat marrow derived cells. Ficoll cells produced less adverse effects at the time of reinfusion, while, as expected, the time of hematopoietic recovery was delayed in these patients (mafosfamide treated cells). These results confirm the usefulness of the gradient density cell separation to reduce the side effects of the DMSO and to make reliable the Mafosfamide purging manoeuvre, preventing the interference of contaminating RBC aldehyde dehydrogenase.
- Published
- 1991
24. Collection of peripheral blood stem cells in normal donors.
- Author
-
Iacone A, Quaglietta AM, Dragani A, Berardi A, Di Bartolomeo G, Accorsi P, and Colamartino P
- Subjects
- Blood Donors, Humans, Specimen Handling methods, Blood Component Removal methods, Cell Separation methods, Hematopoietic Stem Cells cytology, Plateletpheresis methods
- Abstract
Although committed progenitor cells have been harvested during the standard plateletpheresis, only few experiences were specifically carried out in normal donors. The major drawback is the very low number of circulating haemopoietic stem cells and, besides a donor manipulation, a good harvesting technology is a fundamental prerequisite. To verify the effectiveness of an automate system, twenty normal volunteer donors were randomly assigned to four protocols of simultaneous PBSC and platelet collection. A Baxter separator CS 3000 was employed and we compared the yields and the efficiency of the modified Program 1 plus isoradial chamber (Protocol A), the modified Program 1 plus granulo chamber (Protocol B), the standard Program 3 plus isoradial chamber (Protocol C) and the standard Program 3 plus granulo chamber (Protocol D). The absolute yields for WBC (x10(9)), MNC (x10(9)), platelets (x10(11)) and CFU-GM (x10(4)) were respectively: 10.4, 10.1, 6.5 and 29.5 for Protocol A; 10.1, 9.9, 5.2 and 14.7 for Protocol B; 10.0, 9.9, 5.2, 14.7 for Protocol C, and 12.7, 12.4, 6.8 and 57.4 for Protocol D. The best CFU-GM efficiency was achieved with Protocol D (33%) vs. Protocol A (27.5%), Protocol B (14.5%) and Protocol C (27%). The above differences, although remarkable, were not statistically significant. Though preliminary, this study demonstrates the feasibility of a combined platelet and PBSC collection in normal donors.
- Published
- 1990
25. Pharmacological mobilization of haemopoietic progenitor cells in human peripheral blood.
- Author
-
Berardi A, Geraci L, Quaglietta AM, Di Bartolomeo G, and Dragani A
- Subjects
- Adult, Female, Humans, Male, Hematopoietic Stem Cells drug effects, Leucovorin pharmacology, Prednisone pharmacology
- Abstract
We investigated Prednisone (PRD) and Folinic Acid (FA) ability to recruit stem cells (CFU-S) into the circulating compartment, evaluating CFU-GM, BFU-E and CFU-GEMM count increases in peripheral blood (PB). Fifteen healthy donors were administered 75 mg PRD in one trial, and 15 mg FA p.o. through 5 consecutive days in another trial. We observed a significant expansion for BFU-E and CFU-GEMM compartments, though not parallelled by CFU-GM expansion. FA determined a significant increase in CFU-GM on the 5th day of administration, as well as in BFU-E on day 7. It fails to raise CFU-GEMM. The authors suggest a less empiric persuing for such attempts to optimize the use of non-chemotherapic drugs to recruit hemopoietic precursors into PB, so that these can suit to meet stem cell needs for autologous and allogeneic transplantations.
- Published
- 1990
26. Infection after autologous blood-derived stem cell transplantation.
- Author
-
D'Antonio D, Iacone A, Fioritoni G, Angelini A, Dragani A, Betti S, Di Bartolomeo P, Di Bartolomeo G, Accorsi P, and Quaglietta AM
- Subjects
- Adolescent, Adult, Female, Humans, Male, Middle Aged, Retrospective Studies, Blood Transfusion, Autologous adverse effects, Hematopoietic Stem Cell Transplantation, Infections etiology
- Abstract
Ten patients who underwent autologous blood-derived stem cell transplantation (APBSCT) were studied retrospectively to determine the frequency and outcome of transplant associated infections during the hemopoietic reconstitution. Six patients developed an infection after transplant. Severe bacterial infections were unfrequent and mostly caused by gram-positive cocci. In no case pneumonia was observed and this scarce morbility of infection could be the result of early engraftment. None of them died for infection. The frequency of infections in APBSCT patients appears lower than the one observed in autologous bone marrow transplant patients.
- Published
- 1990
27. [Electrocardiographic changes after resection of postinfarction left ventricular aneurysm].
- Author
-
Frabetti L, Rapezzi C, Capucci A, Ferlito M, Di Bartolomeo G, and Magnani B
- Subjects
- Adult, Aged, Angina Pectoris etiology, Arrhythmias, Cardiac etiology, Electrocardiography, Female, Heart Aneurysm complications, Heart Aneurysm etiology, Heart Block etiology, Heart Septal Defects, Ventricular etiology, Heart Ventricles, Humans, Male, Middle Aged, Heart Aneurysm surgery, Myocardial Infarction complications
- Published
- 1982
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