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151 results on '"Futagami, Masayuki"'

3. Ovarian Mesonephric-like Adenocarcinoma Recurring With a Rhabdomyosarcoma Component: A Case Report

Author

Yamamoto, Akiko, primary, Nagai, Takeshi, additional, Sukeda, Aoi, additional, Kajiwara, Manami, additional, Fukunaga, Masaharu, additional, Sasaki, Toru, additional, Kinoshita, Yuta, additional, Hayashi, Motoshige, additional, Hayashi, Shigehiro, additional, Ono, Masataka, additional, Futagami, Masayuki, additional, and Nishi, Hirotaka, additional

Published
2023
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5. Protocol for a Prospective Cohort Study to Evaluate Changes in Sexuality in Patients With Primary Cervical Cancer Using Patient-Reported Outcomes (JGOG9004, SARAH Study), and Our Approaches to Solving the Unmet Needs of Patients With Gynecological Cancer

Author

Sakai, Hitomi, primary, Itani, Yoshio, additional, Kobayashi, Yoichi, additional, Asai-Sato, Mikiko, additional, Tasaki, Kazuto, additional, Nagao, Shoji, additional, Futagami, Masayuki, additional, Yamamoto, Makoto, additional, Fujimoto, Etsuko, additional, Ikeda, Yuji, additional, Yokota, Megumi, additional, Hayashi, Nobutaka, additional, Matsuura, Motoki, additional, Nagasawa, Takayuki, additional, Ishidera, Yumi, additional, Sato, Shinya, additional, Hamano, Tetsutaro, additional, Suzuki, Nao, additional, and Yoshida, Yoshio, additional

Published
2023
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7. Ovarian Mesonephric-like Adenocarcinoma Recurring With a Rhabdomyosarcoma Component: A Case Report

Author

Yamamoto, Akiko, Nagai, Takeshi, Sukeda, Aoi, Kajiwara, Manami, Fukunaga, Masaharu, Sasaki, Toru, Kinoshita, Yuta, Hayashi, Motoshige, Hayashi, Shigehiro, Ono, Masataka, Futagami, Masayuki, and Nishi, Hirotaka

Abstract

Mesonephric-like adenocarcinoma (MLA) has recently been described as a tumor of the endometrium or ovaries, which, morphologically and immunohistochemically, resembles mesonephric adenocarcinoma arising mostly in the uterine cervix. Herein, we report, to our knowledge, the first case of ovarian MLA that developed into an extremely rapidly growing recurrent mesonephric-like carcinosarcoma, as confirmed by a genomic profiling test. A 51-year-old woman underwent chemotherapy with complete debulking surgery for ovarian carcinoma. Pathologically, the patient was diagnosed with stage IVB ovarian MLA. Subsequent to 15 months of complete remission, an enhanced computed tomography scan revealed a solid tumor of 10 cm diameter in the abdominal cavity. Secondary surgery was terminated with a 2 cm2tumor biopsy specimen collection considering perioperative complications. Histologically, the tumor consisted of short spindle cells, and immunohistochemical staining revealed a rhabdomyosarcomatous profile without an epithelial component. Despite treatment for the sarcoma, she died 3 months after the detection of the tumor. The genomic profiling of the primary ovarian carcinoma and secondary resected tumor biopsy specimens revealed an identical KRASmutation in both. Therefore, we concluded that the ovarian MLA recurred with a rhabdomyosarcoma component.

Published
2024
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8. Retrospective comparative study of robot‐assisted surgery, laparoscopic surgery, and laparotomy for endometrial cancer in patients with a low risk of recurrence.

Author

Hayashi, Shigehiro, Yamanaka, Zenta, Kojima, Junya, Ono, Masataka, Sasaki, Toru, Yamamoto, Akiko, Ono, Masanori, Futagami, Masayuki, and Nishi, Hirotaka

Subjects
STATISTICS, SURGICAL blood loss, SURGICAL robots, MULTIVARIATE analysis, CANCER relapse, LAPAROSCOPIC surgery, RETROSPECTIVE studies, TREATMENT effectiveness, RISK assessment, COMPARATIVE studies, ENDOMETRIAL tumors, ABDOMINAL surgery, DESCRIPTIVE statistics, PROGRESSION-free survival, BLOOD loss estimation, OVERALL survival, DISEASE risk factors, EVALUATION
Abstract

Aim: Minimally invasive surgeries for endometrial cancer are increasing worldwide. In Japan, some articles have examined surgical outcomes, but only a few have addressed oncological outcomes. This study aims to compare robot surgery, laparoscopic surgery, and laparotomy in terms of surgical and oncological outcomes within a low‐risk group for endometrial cancer recurrence. Methods: This study included patients with endometrial cancer deemed to be at low risk of recurrence and who underwent surgery between January 2011 and December 2020. We studied 99 patients who underwent robot surgery, 85 patients who underwent laparotomy, and 77 patients who underwent laparoscopic surgery. Surgical and oncological outcomes were compared retrospectively for these groups of patients. Results: The median follow‐up period was 47, 61, and 60 months in the laparotomy, laparoscopy, and robotic groups, respectively. The three groups had similar perioperative and pathological data. No significant differences in overall survival and disease‐free survival were observed among the groups. Univariate and multivariate analyses conducted on the overall study population for disease‐free survival and overall survival showed that the surgical approach did not have any influence. Minimally invasive surgery groups had longer operating times compared to the laparotomy group, but they had significantly less blood loss. The number of resected pelvic lymph nodes was similar, and the complication rate was not significant. Conclusions: Robot‐assisted surgery and laparoscopic surgery were found to be less invasive and showed similar oncologic outcomes compared to laparotomy surgery for endometrial cancer in patients with a low risk of recurrence. [ABSTRACT FROM AUTHOR]

Published
2024
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9. Effectiveness of the Traditional Japanese Medicine Goshajinkigan in Preventing Paclitaxel-Induced Peripheral Neuropathy: A Multicenter Randomized Comparative Trial.

Author

Matsumura, Yukiko, Futagami, Masayuki, Baba, Tsukasa, Soeda, Shu, Watari, Hidemichi, Terada, Yukihiro, Tokunaga, Hideki, Nagase, Satoru, Nakanishi, Toru, Kaiho, Michiko, and Yokoyama, Yoshihito

Abstract

Objective: Development of chemotherapy-induced peripheral neuropathy (CIPN) poses significant challenges in cancer treatment, often leading to dose reductions or treatment discontinuation. Goshajinkigan (GJG), a traditional Japanese medicine, has shown promise for alleviating CIPN symptoms. This multicenter, randomized controlled trial aimed to prospectively examine the efficacy of GJG in preventing paclitaxel-induced peripheral neuropathy. Methods: This study enrolled 55 patients with ovarian cancer undergoing first-line chemotherapy using paclitaxel and carboplatin. The participants were randomized into Groups A (GJG initiation after onset of grade 2 neuropathy) and B (prophylactic administration of GJG from 1 week before chemotherapy). The primary endpoints were the proportion with a maximum sensory neuropathy grade and visual analog scale (VAS) scores. The secondary endpoints were the rate of chemotherapy completion and paclitaxel dose reduction due to neurotoxicity. Results: Prophylactic GJG administration (Group B) resulted in significant benefits. While both groups had a similar incidence of grade 2 sensory neuropathy, all patients in Group B with grade 2 neuropathy completed treatment without requiring additional analgesics. Group B exhibited lower VAS scores by the end of the study, reduced reliance on adjuvant analgesics (27.3% vs 66.7% in Group A), and significantly less frequent persistent CIPN 6 months post-chemotherapy (18.2% vs 55.6% in Group A). No differences were observed in the chemotherapy completion rates or CIPN-related changes between the groups. Conclusion: GJG, when administered prophylactically, showed potential for mitigating CIPN symptoms during paclitaxel chemotherapy. While promising, further research with placebo controls and objective measures is essential to comprehensively validate these findings. [ABSTRACT FROM AUTHOR]

Published
2024
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10. Comparison of older and younger patients with ovarian cancer: A post hoc study (JGOG3016‐A3) of the treatment strength and prognostic outcomes of conventional or dose‐dense chemotherapy

Author

Itani, Yoshio, primary, Sakai, Hitomi, additional, Hamano, Tetsutaro, additional, Asai‐Sato, Mikiko, additional, Futagami, Masayuki, additional, Fujimura, Masaki, additional, Aoki, Yoichi, additional, Suzuki, Nao, additional, Yoshida, Yoshio, additional, and Enomoto, Takayuki, additional

Published
2023
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11. Perioperative heart rate variability analysis to evaluate autonomic activity in gynecologic patients

Author

Annells, Azusa, Futagami, Masayuki, Osawa, Yuki, Oishi, Maika, Washima, Haruka, Sugimoto, Rina, Tsushima, Ryuto, Takenoko, Kenichi, Kurotaki, Saki, Taguchi, Tomoko, Maeda, Jyuria, Kadonosawa, Yuka, Ebina, Anna, Akaishi, Asami, Miura, Rie, Matsumura, Yukiko, and Yokoyama, Yoshihito

Subjects
gynecologic surgery, heart rate variability, visual analog scale, menopausal patients, autonomic activity
Abstract

ackground: Women often experience medically unexplained symptoms as they age, and their possible causesinclude changes in autonomic activity. Heart rate variability is a relevant marker for autonomic function. Methods: The autonomic activities of patients who underwent gynecologic surgery were prospectively measured andevaluated by menopausal status. Parameters included the standard deviation of the mean R-to-R intervals （SDNN）and index of the sympathetic nervous system（ SNS） function. Patients also evaluated the severity of their headache,hot flashes, anxiety, irritability, fatigue and shoulder stiffness using the visual analog scale （VAS-P, VAS-H, VAS-A,VAS-I, VAS-F and VAS-S, respectively）. Measurements were conducted shortly before, immediately after, and 1week after surgery. Results: The study cohort （N = 101） consisted of 14 premenopausal, 39 surgically menopausal, and 48 naturallymenopausal patients. At 1 week after surgery, surgically menopausal patients had significantly smaller mean SDNNthan premenopausal patients. Surgically menopausal patients also showed significant correlation between the SNSindex and VAS-I and VAS-F. Conclusions: The SNS index in surgically menopausal patients can be a promising tool for evaluating the severityof menopausal symptoms. Parasympathetic nerve activity decreased immediately after the operation in the surgicalmenopausal group. Therefore, early hormone replacement therapy may be necessary in surgical menopause group.

Published
2022

12. A phase II study of irinotecan and pegylated liposomal doxorubicin in platinum-resistant recurrent ovarian cancer (Tohoku Gynecologic Cancer Unit 104 study)

Author

Shoji, Tadahiro, Takatori, Eriko, Omi, Hideo, Kagabu, Masahiro, Honda, Tatsuya, Futagami, Masayuki, Yokoyama, Yoshihito, Kaiho, Michiko, Tokunaga, Hideki, Otsuki, Takeo, Takano, Tadao, Yaegashi, Nobuo, Kojimahara, Takanobu, Ohta, Tsuyoshi, Nagase, Satoru, Soeda, Shu, Watanebe, Takafumi, Nishiyama, Hiroshi, and Sugiyama, Toru

Published
2017
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16. Investigation of the clinicopathological features of squamous cell carcinoma of the vulva: a retrospective survey of the Tohoku Gynecologic Cancer Unit

Author

Futagami, Masayuki, Yokoyama, Yoshihito, Iino, Kaori, Aoki, Masahiko, Shoji, Tadahiro, Sugiyama, Toru, Ariga, Hisanori, Tokunaga, Hideki, Takano, Tadao, Watanabe, Yoh, Yaegashi, Nobuo, Jingu, Keiichi, Sato, Naoki, Terada, Yukihiro, Anbai, Akira, Ohta, Tsuyoshi, Kurachi, Hirohisa, Kuroda, Yuuki, Nishiyama, Hiroshi, Fujimori, Keiya, Watanabe, Takafumi, Sato, Hisashi, Tase, Toru, Wada, Hitoshi, and Mizunuma, Hideki

Published
2015
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18. Renal metastasis of ovarian granulosa cell tumor

Author

Togashi, Kyo, primary, Yoneyama, Tohru, additional, Sutoh Yoneyama, Mihoko, additional, Yamamoto, Hayato, additional, Hatakeyama, Shingo, additional, Yoneyama, Takahiro, additional, Hashimoto, Yasuhiro, additional, Futagami, Masayuki, additional, and Ohyama, Chikara, additional

Published
2022
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22. Quantitative evaluation of chemotherapy‑induced peripheral neuropathy by using intraepidermal electrical stimulation

Author

Oyama, Fumie, primary, Futagami, Masayuki, additional, Oikiri, Hiroe, additional, Takabayashi, Anna, additional, Akaishi, Asami, additional, Kodama, Tomoe, additional, Matsumoto, Mami, additional, Kanamori, Masahiro, additional, Oishi, Maika, additional, Miura, Rie, additional, Hirakawa, Hachidai, additional, and Yokoyama, Yoshihito, additional

Published
2020
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26. Clinical and reproductive outcomes of fertility‑sparing surgery in stage�I epithelial ovarian cancer

Author

Watanabe, Takafumi, primary, Soeda, Shu, additional, Nishiyama, Hiroshi, additional, Kiko, Yuichiroh, additional, Tokunaga, Hideki, additional, Shigeta, Shogo, additional, Yaegashi, Nobuo, additional, Yamada, Hidekazu, additional, Ohta, Tsuyoshi, additional, Nagase, Satoru, additional, Shoji, Tadahiro, additional, Kagabu, Masahiro, additional, Baba, Tsukasa, additional, Shimizu, Dai, additional, Sato, Naoki, additional, Terada, Yukihiro, additional, Futagami, Masayuki, additional, Yokoyama, Yoshihito, additional, and Fujimori, Keiya, additional

Published
2019
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30. Clinicopathologic features, treatment, prognosis and prognostic factors of neuroendocrine carcinoma of the endometrium: a retrospective analysis of 42 cases from the Kansai Clinical Oncology Group/Intergroup study in Japan

Author

Matsumoto, Harunobu, primary, Shimokawa, Mototsugu, additional, Nasu, Kaei, additional, Shikama, Ayumi, additional, Shiozaki, Takaya, additional, Futagami, Masayuki, additional, Kai, Kentaro, additional, Nagano, Hiroaki, additional, Mori, Taisuke, additional, Yano, Mitsutake, additional, Sugino, Norihiro, additional, Fujimoto, Etsuko, additional, Yoshioka, Norihito, additional, Nakagawa, Satoshi, additional, Shimada, Muneaki, additional, Tokunaga, Hideki, additional, Yamada, Yuki, additional, Tsuruta, Tomohiko, additional, Tasaki, Kazuto, additional, Nishikawa, Ryutaro, additional, Kuji, Shiho, additional, Motohashi, Takashi, additional, Ito, Kimihiko, additional, Yamada, Takashi, additional, and Teramoto, Norihiro, additional

Published
2019
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31. Multicenter Clinicopathological Study of High-Grade Serous Carcinoma Presenting as Primary Peritoneal Carcinoma

Author

Komiyama, Shinichi, primary, Nishijima, Yoshihiro, additional, Kondo, Haruhiro, additional, Nomura, Hiroyuki, additional, Yamaguchi, Satoshi, additional, Futagami, Masayuki, additional, Arai, Hiroharu, additional, Yokoyama, Yoshihito, additional, Suzuki, Nao, additional, Mikami, Mikio, additional, Kubushiro, Kaneyuki, additional, Aoki, Daisuke, additional, Udagawa, Yasuhiro, additional, and Nishimura, Ryuichiro, additional

Published
2018
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33. Clinical and reproductive outcomes of fertility-sparing surgery in stage I epithelial ovarian cancer.

Author

Watanabe, Takafumi, Soeda, Shu, Nishiyama, Hiroshi, Kiko, Yuichiroh, Tokunaga, Hideki, Shigeta, Shogo, Yaegashi, Nobuo, Yamada, Hidekazu, Ohta, Tsuyoshi, Nagase, Satoru, Shoji, Tadahiro, Kagabu, Masahiro, Baba, Tsukasa, Shimizu, Dai, Sato, Naoki, Terada, Yukihiro, Futagami, Masayuki, Yokoyama, Yoshihito, and Fujimori, Keiya

Subjects
OVARIAN epithelial cancer, OVARIAN function tests, GYNECOLOGIC cancer, LOG-rank test, STATISTICAL significance
Abstract

The aim of the present study was to evaluate the oncologic safety and reproductive outcome in patients with stage I epithelial ovarian cancer (EOC) treated with fertility-sparing surgery (FSS). Women aged ≤40 years with stage I EOC who had undergone FSS between 2000 and 2010 were retrospectively reviewed. Survival was examined using the Kaplan-Meier method and statistical significance was analyzed using the log-rank test. A total of 29 EOC patients (stage IA, n=14; stage IC1 n=6; stage IC3, n=9) from seven participating institutions belonging to the Tohoku Gynecologic Cancer Unit were enrolled. After a median follow-up duration of 60.6 months (range, 6–135 months), five patients (17.2%) experienced tumor recurrence. The respective five-year relapse-free survival (RFS) and overall survival (OS) rates were 90.9 and 100% for stage IA/IC1, and 43.8 and 87.5% for stage IC3. Significant differences in RFS were observed between stage IA/IC1 and IC3 patients (P=0.026). However, there was no significant difference in OS between patients with 1A/1C1 and those with 1C3 (P=0.712). After FSS, seven pregnancies occurred in five patients, which resulted in the birth of six healthy children. The results of the present study confirmed that FSS may be an acceptable treatment method for stage IA and IC1 EOC, exhibiting a favorable reproductive outcome. However, the safety of FSS for treating stage IC3 EOC is uncertain and warrants further investigation. [ABSTRACT FROM AUTHOR]

Published
2020
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34. Differences in the sensitivity of ovarian cancer to photodynamic therapy and the mechanisms for those differences

Author

Yokoyama, Yoshihito, Shigeto, Tatsuhiko, Miura, Rie, Kobayashi, Asami, Mizunuma, Makito, Yamauchi, Aisa, Futagami, Masayuki, Mizunuma, Hideki, Yokoyama, Yoshihito, Shigeto, Tatsuhiko, Miura, Rie, Kobayashi, Asami, Mizunuma, Makito, Yamauchi, Aisa, Futagami, Masayuki, and Mizunuma, Hideki

Abstract

Protoporphyrin IX (PpIX) levels are crucial to the antitumor action of photodynamic therapy (PDT). In the present study, the underling molecular mechanisms for the variation in PpIX levels in ovarian cancer cells were investigated. Five ovarian cancer cell lines were subcutaneously grafted onto the backs of nude mice. Once tumors had developed, 5-aminolevulinic acid methyl ester hydrochloride (methyl-ALA) was administered intraperitoneally and the tumor was irradiated twice/week. PpIX levels in the tumor were assayed using high-performance liquid chromatography. Enzymes involved in heme synthesis and degradation were screened using a microarray technique. Expression of the glutathione transferase Omega-1 (GSTO1) gene involved in the conversion of PpIX into heme in cells was quantified using the reverse transcription-quantitative polymerase chain reaction. In HTOA, HRA and DISS cells, PDT resulted in significant tumor shrinkage in comparison with the controls. In MCAS and TOV21G cells, no significant alterations in tumor growth were identified compared with the untreated cells. PpIX levels increased significantly in HTOA, DISS and HRA cells compared with in MCAS and TOV21G cells. A comparison of genetic profiles using PDT-sensitive DISS cells and PDT-resistant MCAS cells indicated that MCAS cells exhibited significantly increased levels of delta-aminolevulinate synthase (a rate-limiting enzyme in heme synthesis), heme oxygenase 2 (an enzyme that degrades heme into biliverdin), and biliverdin reductase B (an enzyme that reduces biliverdin into bilirubin) in comparison with DISS cells. The level of GSTO1 expression in HTOA, HRA and DISS cells was similar to 2.5-fold that in MCAS and TOV21G cells. Sensitivity to PDT is related to PpIX levels in cells. The results of the present study suggested that PpIX tends not to accumulate in PDT-resistant cells despite active heme synthesis and degradation, and that high levels of GSTO1 expression are associated with increased sens

Published
2017

39. Paclitaxel and Carboplatin in Patients With Completely or Optimally Resected Carcinosarcoma of the Uterus: A Phase II Trial by the Japanese Uterine Sarcoma Group and the Tohoku Gynecologic Cancer Unit

Author

Otsuki, Ai, primary, Watanabe, Yoh, additional, Nomura, Hiroyuki, additional, Futagami, Masayuki, additional, Yokoyama, Yoshihito, additional, Shibata, Kiyosumi, additional, Kamoi, Seiryu, additional, Arakawa, Atsushi, additional, Nishiyama, Hiroshi, additional, Katsuta, Takahiro, additional, Kudaka, Wataru, additional, Shimada, Muneaki, additional, Sato, Naoki, additional, Kotera, Kouhei, additional, Katabuchi, Hidetaka, additional, and Yaegashi, Nobuo, additional

Published
2015
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42. L-type Amino Acid Transporter 1 Expression Increases in Well-Differentiated but Decreases in Poorly Differentiated Endometrial Endometrioid Adenocarcinoma and Shows an Inverse Correlation With p53 Expression

Author

Watanabe, Jun, primary, Yokoyama, Yoshihito, additional, Futagami, Masayuki, additional, Mizunuma, Hideki, additional, Yoshioka, Haruhiko, additional, Washiya, Kiyotada, additional, Hana, Kiyomi, additional, Endou, Hitoshi, additional, and Okayasu, Isao, additional

Published
2014
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45. Redistribution of resistance and sensitivity to platinum during the observation period following treatment of epithelial ovarian cancer

Author

YOKOYAMA, YOSHIHITO, primary, FUTAGAMI, MASAYUKI, additional, WATANABE, JUN, additional, SATO, NAOKI, additional, TERADA, YUKIHIRO, additional, MIURA, FUMIHARU, additional, SUGIYAMA, TORU, additional, TAKANO, TADAO, additional, YAEGASHI, NOBUO, additional, KOJIMAHARA, TAKANOBU, additional, KURACHI, HIROHISA, additional, NISHIYAMA, HIROSHI, additional, FUJIMORI, KEIYA, additional, TASE, TORU, additional, and MIZUNUMA, HIDEKI, additional

Published
2013
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46. A Case of Small Cell Carcinoma of the Vagina

Author

Tamura, Ryosuke, primary, Yokoyama, Yoshihito, additional, Kobayashi, Asami, additional, Osawa, Yuuki, additional, Shigeto, Tatsuhiko, additional, Futagami, Masayuki, additional, and Mizunuma, Hideki, additional

Published
2013
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47. Investigation of the clinicopathological features of fallopian tube malignancy

Author

YOKOYAMA, YOSHIHITO, primary, FUTAGAMI, MASAYUKI, additional, FUJIMOTO, TOSHIO, additional, TERADA, YUKIHIRO, additional, TAKATORI, ERIKO, additional, SUGIYAMA, TORU, additional, OTSUKI, TAKEO, additional, YAEGASHI, NOBUO, additional, KOJIMAHARA, TAKANOBU, additional, KURACHI, HIROHISA, additional, NISHIYAMA, HIROSHI, additional, FUJIMORI, KEIYA, additional, TASE, TORU, additional, and MIZUNUMA, HIDEKI, additional

Published
2013
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48. Loss of ARID1A Expression Is an Early Molecular Event in Tumor Progression From Ovarian Endometriotic Cyst to Clear Cell and Endometrioid Carcinoma

Author

Ayhan, Ayse, primary, Mao, Tsui-Lien, additional, Seckin, Tamer, additional, Wu, Chen-Hsuan, additional, Guan, Bin, additional, Ogawa, Hiroshi, additional, Futagami, Masayuki, additional, Mizukami, Hiroki, additional, Yokoyama, Yoshihito, additional, Kurman, Robert J., additional, and Shih, Ie-Ming, additional

Published
2012
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