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1. Long-term functional outcomes and surgical retreatment after thulium laser enucleation of the prostate: A 10-year follow-up study

Author

Manfredi, Celeste, primary, Napolitano, Luigi, additional, Ditonno, Francesco, additional, Fusco, Giovanni Maria, additional, Quattrone, Carmelo, additional, Sio, Marco De, additional, Romis, Luca, additional, Riccardo, Filippo, additional, Nugnes, Maria Rosaria, additional, Lauro, Giovanni Di, additional, and Trama, Francesco, additional

Published
2024
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2. Sexual Dysfunctions and Gynecomastia in Male Rheumatological Patients Treated with Methotrexate: A Systematic Review.

Author

Napolitano, Luigi, Abate, Marco, Di Bello, Francesco, Morra, Simone, Cirillo, Luigi, Fusco, Giovanni Maria, Califano, Gianluigi, Collà Ruvolo, Claudia, Creta, Massimiliano, La Rocca, Roberto, Crocetto, Felice, Barone, Biagio, Pantano, Ilenia, Russo, Pierluigi, Arcaniolo, Davide, and Manfredi, Celeste

Subjects
IMPOTENCE, SEXUAL dysfunction, RHEUMATISM, RANDOMIZED controlled trials, GYNECOMASTIA, RHEUMATOID arthritis
Abstract

Objectives: The aim of the current review was to elucidate the clinical context and presentation of sexual dysfunction (SD) and gynecomastia in rheumatological patients undergoing methotrexate treatment. Moreover, we aimed also to make physicians aware of the occurrence of these side effects, to adequately inform the patient before starting treatment. Methods: Systematic review (PROSPERO id: CRD42022358275) was performed according to preferred reporting items for systematic reviews and meta-analyses. Studies (1 January 1995 to 31 May 2022) were identified by highly sensitive searches of electronic databases (Medline, Embase, Cochrane Library databases). Key terms included: (("sexual dysfunction" OR "erectile dysfunction" OR "impotence") AND ("methotrexate" OR "MTX")) and (("gynecomastia" OR "male breast") AND ("methotrexate" OR "MTX")). Results: A total of seven papers (seven case reports), involving a total of eleven patients (min one, max three), were included in the final analysis. The age of the patients ranged from 19 to 68 years (median: 50.9 years). Rheumatoid arthritis (RA) was the most frequent rheumatic disease reported (n = 8, 72.7%). No patients reported erectile dysfunction (ED) and/or gynecomastia before using MTX. Time to onset of SD and gynecomastia after MTX ranged from 2 to 104 weeks (median: 22.7 weeks). ED (n = 5, 45.4%) and gynecomastia (n = 3, 27.2%) were the most common forms of presentation. Conclusions: Future prospective controlled studies with a large sample size and long follow-up as well as randomized controlled trials are needed to confirm this association, investigate its pathophysiological basis, assess the safest dosages, evaluate the most appropriate management, and provide clear recommendations. [ABSTRACT FROM AUTHOR]

Published
2024
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3. The role of lipidic balance on erectile dysfunction in prostate cancer patients undergoing robotic surgery.

Author

Di Bello, Francesco, Fraia, Agostino, Pezone, Gabriele, Collà Ruvolo, Claudia, Di Mauro, Ernesto, Cirillo, Luigi, Fusco, Giovanni Maria, Morra, Simone, Aprea, Salvatore, La Rocca, Roberto, Califano, Gianluigi, Creta, Massimiliano, Longo, Nicola, and Napolitano, Luigi

Subjects
PROSTATE cancer patients, SURGICAL robots, RADICAL prostatectomy, IMPOTENCE, REGRESSION analysis
Abstract

Objective: New indices of dyslipidemia, such as the Atherogenic Index of Plasma (AIP) or Castelli Risk Index I and II (CR‐I/II), have been tested to predict erectile dysfunction (ED). The aim of this study was to assess the role of these lipidic scores in predicting severe ED and erectile function (EF) worsening in patients who underwent robot‐assisted radical prostatectomy (RARP). Methods: Data from 1249 prostate cancer patients who underwent RARP at our single tertiary academic referral center from September 2021 to April 2023 were reviewed. RARP patients with a complete lipid panel were included in the final analysis. Two independent multivariable logistic regression models (LRMs) were fitted to identify predictors of ED severity and worsening in RARP patients. Results: Among the 357 RARP patients, the median age was 70 (interquartile range [IQR]: 65–74), and the median BMI was 28.4 (IQR: 26–30.4). According to the preoperative IIEF5, 115 (32.2%), 86 (24.5%), 26 (7.3%), and 40 (11.2%) were mild, mild‐moderate, moderate, and severe ED patients, respectively. After multivariable LRMs predicting severe ED, only the nerve‐sparing (NS) approach (odds ratio [OR]: 0.09) as well as the preoperative IIEF5 score (OR: 0.32) were independent predictors (p < 0.001). After LRMs predicting EF worsening, only preoperative IIEF5 was an independent predictor (OR: 1.42, p < 0.001). Conclusion: The power of novel lipidic scores in predicting severe ED and EF worsening in RARP patients was low, and they should not be routinely applied as a screening method in this patient subgroup. Only preoperative IIEF5 and nerve‐sparing approaches are relevant in EF prediction after RARP. [ABSTRACT FROM AUTHOR]

Published
2024
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4. Telemedicine and social media: A contemporary analysis of the most shared content by internet users

Author

Mirone, Vincenzo, primary, Di Bello, Francesco, additional, Morra, Simone, additional, Califano, Gianluigi, additional, Cirillo, Luigi, additional, Abate, Marco, additional, Fusco, Giovanni Maria, additional, Luzzago, Stefano, additional, Mirone, Claudia, additional, Napolitano, Luigi, additional, La Rocca, Roberto, additional, Creta, Massimiliano, additional, Celentano, Giuseppe, additional, Capece, Marco, additional, Musi, Gennaro, additional, Mangiapia, Francesco, additional, Longo, Nicola, additional, and Collà Ruvolo, Claudia, additional

Published
2024
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5. Carbapenem-Resistant Enterobacteriaceae in Urinary Tract Infections: From Biological Insights to Emerging Therapeutic Alternatives

Author

Bologna, Eugenio, primary, Licari, Leslie Claire, additional, Manfredi, Celeste, additional, Ditonno, Francesco, additional, Cirillo, Luigi, additional, Fusco, Giovanni Maria, additional, Abate, Marco, additional, Passaro, Francesco, additional, Di Mauro, Ernesto, additional, Crocetto, Felice, additional, Pandolfo, Savio Domenico, additional, Aveta, Achille, additional, Cilio, Simone, additional, Di Filippo, Isabella, additional, Barone, Biagio, additional, Franco, Antonio, additional, Arcaniolo, Davide, additional, La Rocca, Roberto, additional, Pinchera, Biagio, additional, and Napolitano, Luigi, additional

Published
2024
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6. A mobile health application for prostate cancer antigen dosage: is it time to say goodbye to classic screening methods?

Author

Di Bello, Francesco, primary, di Mauro, Ernesto, additional, Fusco, Giovanni Maria, additional, Falcone, Alfonso, additional, Pezone, Gabriele, additional, Ruvolo, Claudia Collà, additional, Califano, Gianluigi, additional, Fraia, Agostino, additional, Passaro, Francesco, additional, Pepillo, Francesco, additional, Ranieri, Alessandro, additional, Alvino, Pierluigi, additional, Mastrangelo, Francesco, additional, Turco, Carmine, additional, Cirillo, Luigi, additional, Franzese, Corrado Aniello, additional, La Rocca, Roberto, additional, Creta, Massimiliano, additional, Longo, Nicola, additional, and Napolitano, Luigi, additional

Published
2023
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7. Thromboembolic Events after COVID-19 Vaccination: An Italian Retrospective Real-World Safety Study

Author

Bernardi, Francesca Futura, primary, Mascolo, Annamaria, additional, Sarno, Marina, additional, Capoluongo, Nicolina, additional, Trama, Ugo, additional, Ruggiero, Rosanna, additional, Sportiello, Liberata, additional, Fusco, Giovanni Maria, additional, Bisogno, Massimo, additional, Coscioni, Enrico, additional, Iervolino, Anna, additional, Di Micco, Pierpaolo, additional, Capuano, Annalisa, additional, and Perrella, Alessandro, additional

Published
2023
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8. Thromboembolic Events after COVID-19 Vaccination: An Italian Retrospective Real-World Safety Study

Author

Bernardi, Francesca furtura, primary, Mascolo, Annamaria, additional, Sarno, Marina, additional, Capoluongo, Nicolina, additional, Trama, Ugo, additional, Ruggiero, Rosanna, additional, Sportiello, Liberata, additional, Fusco, Giovanni Maria, additional, Bisogno, Massimo, additional, Coscioni, Enrico, additional, Di micco, Pierpaolo, additional, Capuano, Annalisa, additional, and Perrella, Alessandro, additional

Published
2023
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9. A mobile health application for prostate cancer antigen dosage: is it time to say goodbye to classic screening methods?

Author

Di Bello, Francesco, di Mauro, Ernesto, Fusco, Giovanni Maria, Falcone, Alfonso, Pezone, Gabriele, Ruvolo, Claudia Collà, Califano, Gianluigi, Fraia, Agostino, Passaro, Francesco, Pepillo, Francesco, Ranieri, Alessandro, Alvino, Pierluigi, Mastrangelo, Francesco, Turco, Carmine, Cirillo, Luigi, Franzese, Corrado Aniello, Rocca, Roberto La, Creta, Massimiliano, Longo, Nicola, and Napolitano, Luigi

Published
2024
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10. Recreation use of phosphodiesterase type 5 inhibitors, the other side of erectile dysfunction

Author

Fusco, Giovanni Maria, primary, Cirillo, Luigi, additional, Mastrangelo, Francesco, additional, Romano, Francesco, additional, Di Mauro, Ernesto, additional, Cacace, Gianluigi, additional, Spena, Gianluca, additional, Iannicelli, Annamaria, additional, Franzese, Corrado Aniello, additional, Mirone, Vincenzo, additional, La Rocca, Roberto, additional, and Napolitano, Luigi, additional

Published
2023
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11. Telemedicine and YouTube™: Video quality analysis before and after COVID-19 pandemic

Author

Mirone, Vincenzo, primary, Abate, Marco, additional, Fusco, Giovanni Maria, additional, Cirillo, Luigi, additional, Napolitano, Luigi, additional, Morra, Simone, additional, Di Bello, Francesco, additional, Califano, Gianluigi, additional, Mirone, Claudia, additional, La Rocca, Roberto, additional, Creta, Massimiliano, additional, Celentano, Giuseppe, additional, Capece, Marco, additional, Mangiapia, Francesco, additional, Longo, Nicola, additional, and Collà Ruvolo, Claudia, additional

Published
2023
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12. Sexual dysfunctions of rheumatological patients are a neglected issue: Results from a national survey of Italian Society of Rheumatology

Author

Napolitano, Luigi, primary, Pantano, Ilenia, additional, Romano, Lorenzo, additional, Cirillo, Luigi, additional, Manfredi, Celeste, additional, Matrangelo, Francesco, additional, Fusco, Giovanni Maria, additional, Mauro, Daniele, additional, Spirito, Lorenzo, additional, La Rocca, Roberto, additional, Arcaniolo, Davide, additional, Franzese, Corrado Aniello, additional, Sciorio, Carmine, additional, Romano, Marco, additional, De Sio, Marco, additional, Mirone, Vincenzo, additional, and Ciccia, Francesco, additional

Published
2023
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13. Cytoreductive Nephrectomy and Metastatic Renal Cell Carcinoma: State of the Art and Future Perspectives

Author

Napolitano, Luigi, primary, Manfredi, Celeste, additional, Cirillo, Luigi, additional, Fusco, Giovanni Maria, additional, Passaro, Francesco, additional, Abate, Marco, additional, La Rocca, Roberto, additional, Mastrangelo, Francesco, additional, Spirito, Lorenzo, additional, Pandolfo, Savio Domenico, additional, Crocetto, Felice, additional, Arcaniolo, Davide, additional, and Barone, Biagio, additional

Published
2023
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14. Sexual dysfunction: Time for a multidisciplinary approach?

Author

Cirillo, Luigi, primary, Fusco, Giovanni Maria, additional, Di Bello, Francesco, additional, Morgera, Vincenzo, additional, Cacace, Gianluigi, additional, Di Mauro, Ernesto, additional, Mastrangelo, Francesco, additional, Romano, Lorenzo, additional, Calace, Francesco Paolo, additional, La Rocca, Roberto, additional, and Napolitano, Luigi, additional

Published
2023
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15. Mobile health applications in kidney stone disease management: A reliable support for patients?

Author

Cirillo, Luigi, primary, Manfredi, Celeste, additional, Barone, Biagio, additional, Morgera, Vincenzo, additional, Cacace, Gianluigi, additional, Mastrangelo, Francesco, additional, Di Bello, Francesco, additional, Abate, Marco, additional, Arcaniolo, Davide, additional, Spirito, Lorenzo, additional, Crocetto, Felice, additional, La Rocca, Roberto, additional, Creta, Massimiliano, additional, Calace, Francesco Paolo, additional, Fusco, Giovanni Maria, additional, and Napolitano, Luigi, additional

Published
2023
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16. Perceptions and attitudes toward the use of telemedicine for the postoperative outpatient urological care during the COVID-19 pandemic in an Academic Hospital in Southern Italy

Author

Mirone, Vincenzo, primary, Celentano, Giuseppe, additional, Collà Ruvolo, Claudia, additional, Cirillo, Luigi, additional, Fusco, Giovanni Maria, additional, Abate, Marco, additional, Morra, Simone, additional, Di Bello, Francesco, additional, Califano, Gianluigi, additional, Mirone, Claudia, additional, Cacace, Gianluigi, additional, Morgera, Vincenzo, additional, La Rocca, Roberto, additional, Capece, Marco, additional, Longo, Nicola, additional, Napolitano, Luigi, additional, and Creta, Massimiliano, additional

Published
2022
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17. Male infertility, what Mobile Health Applications “know”: quality analysis and adherence to European Association of Urology Guidelines

Author

Fusco, Giovanni Maria, primary, Cirillo, Luigi, additional, Abate, Marco, additional, Morra, Simone, additional, Morgera, Vincenzo, additional, Barone, Biagio, additional, Crocetto, Felice, additional, Cacace, Gianluigi, additional, Di Bello, Francesco, additional, Spirito, Lorenzo, additional, Manfredi, Celeste, additional, Arcaniolo, Davide, additional, Palmieri, Alessandro, additional, Imbimbo, Ciro, additional, Mirone, Vincenzo, additional, and Napolitano, Luigi, additional

Published
2022
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18. How artificial intelligence during the pandemic modified the role of a biomarker as d-dimer.

Author

Di Micco, Pierpaolo, Bernardi, Francesca Futura, Fusco, Giovanni Maria, and Perrella, Alessandro

Abstract

Artificial intelligence (AI) was introduced in medicine to make some difficult decision-making regarding diagnostics and/or treatments easy. Its application derives from the improvement of information obtained with computer sciences and informatics, in particular with information derived by algorithms obtained with special informatics support as machine learning. The scenario of hospital changes induced by the COVID-19 pandemic makes easy the application of AI for some clinical updates. Being lung failure with pulmonary embolism is the most common cause of death for inpatients with COVID-19, some biomarkers such as the d-dimer are constantly used associated with other clinical features in order to improve medical assistance. For this reason, d-dimer during the pandemic changed its traditional use for predictive negative value in patients with suspected pulmonary embolism and took relevance for its values giving the chance to change the intensity of anticoagulation for several inpatients. In most cases, according to data reported from several cohorts, these changes improved the morbidity and mortality of a significant percentage of inpatients with COVID-19. The International medical prevention registry on venous thromboembolism and d-dimer and modified sepsis-induced coagulopathy scores were the most used scores derived from AI and dedicated to these clinical aspects in inpatients with COVID-19. Therefore, this review was dedicated to flexible changes that we can use after d-dimer values in different clinical scenarios that vary from disseminated intravascular coagulation to pulmonary embolism to COVID-19. [ABSTRACT FROM AUTHOR]

Published
2023
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19. Preoperative Fibrinogen-to-Albumin Ratio as Potential Predictor of Bladder Cancer: A Monocentric Retrospective Study

Author

Barone, Biagio, primary, Napolitano, Luigi, additional, Reccia, Pasquale, additional, De Luca, Luigi, additional, Morra, Simone, additional, Turco, Carmine, additional, Melchionna, Alberto, additional, Caputo, Vincenzo Francesco, additional, Cirillo, Luigi, additional, Fusco, Giovanni Maria, additional, Mastrangelo, Francesco, additional, Calace, Francesco Paolo, additional, Amicuzi, Ugo, additional, Morgera, Vincenzo, additional, Romano, Lorenzo, additional, Trivellato, Massimiliano, additional, Mattiello, Gennaro, additional, Sicignano, Enrico, additional, Passaro, Francesco, additional, Ferretti, Gianpiero, additional, Giampaglia, Gaetano, additional, Capone, Federico, additional, Manfredi, Celeste, additional, and Crocetto, Felice, additional

Published
2022
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21. Premature ejaculation in the era of mobile health application: A current analysis and evaluation of adherence to EAU guidelines

Author

Napolitano, Luigi, primary, Cirillo, Luigi, additional, Fusco, Giovanni Maria, additional, Abate, Marco, additional, Falcone, Alfonso, additional, Morgera, Vincenzo, additional, Cacace, Gianluigi, additional, De Luca, Luigi, additional, Reccia, Pasquale, additional, Mirone, Claudia, additional, Crocetto, Felice, additional, Celentano, Giuseppe, additional, Morra, Simone, additional, Barone, Biagio, additional, Imbimbo, Ciro, additional, Longo, Nicola, additional, Mirone, Vincenzo, additional, and La Rocca, Roberto, additional

Published
2022
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22. Preoperative monocyte-to-lymphocyte ratio as a potential predictor of bladder cancer

Author

Napolitano, Luigi, primary, Barone, Biagio, additional, Reccia, Pasquale, additional, De Luca, Luigi, additional, Morra, Simone, additional, Turco, Carmine, additional, Melchionna, Alberto, additional, Morgera, Vincenzo, additional, Cirillo, Luigi, additional, Fusco, Giovanni Maria, additional, Mirto, Benito Fabio, additional, Napodano, Giorgio, additional, Del Biondo, Dario, additional, Prezioso, Domenico, additional, Imbimbo, Ciro, additional, and Crocetto, Felice, additional

Published
2022
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23. Oral Preparation of Hyaluronic Acid, Chondroitin Sulfate, Curcumin, and Quercetin (Ialuril® Soft Gels) for the Prevention of LUTS after Intravesical Chemotherapy

Author

Manfredi, Celeste, primary, Spirito, Lorenzo, additional, Calace, Francesco Paolo, additional, Balsamo, Raffaele, additional, Terribile, Marco, additional, Stizzo, Marco, additional, Romano, Lorenzo, additional, Napolitano, Luigi, additional, Califano, Gianluigi, additional, Cirillo, Luigi, additional, Fusco, Giovanni Maria, additional, Rosati, Claudia, additional, Quattrone, Carmelo, additional, Sciorio, Carmine, additional, Creta, Massimiliano, additional, Longo, Nicola, additional, De Sio, Marco, additional, and Arcaniolo, Davide, additional

Published
2022
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24. Erectile dysfunction and mobile phone applications: Quality, content and adherence to European Association guidelines on male sexual dysfunction

Author

Napolitano, Luigi, primary, Fusco, Giovanni Maria, additional, Cirillo, Luigi, additional, Abate, Marco, additional, Mirone, Claudia, additional, Barone, Biagio, additional, Celentano, Giuseppe, additional, La Rocca, Roberto, additional, Mirone, Vincenzo, additional, Creta, Massimiliano, additional, and Capece, Marco, additional

Published
2022
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25. Male Sexual Dysfunction and Infertility in Spinal Cord Injury Patients: State-of-the-Art and Future Perspectives

Author

Di Bello, Francesco, primary, Creta, Massimiliano, additional, Napolitano, Luigi, additional, Califano, Gianluigi, additional, Passaro, Francesco, additional, Morra, Simone, additional, Giovanni, Angelo di, additional, Fusco, Giovanni Maria, additional, Cirillo, Luigi, additional, Abate, Marco, additional, Morgera, Vincenzo, additional, Cacace, Gianluigi, additional, De Luca, Luigi, additional, Spena, Gianluca, additional, Collà Ruvolo, Claudia, additional, Calace, Francesco Paolo, additional, Manfredi, Celeste, additional, La Rocca, Roberto, additional, Celentano, Giuseppe, additional, Turco, Carmine, additional, Capece, Marco, additional, D’Alterio, Carlo, additional, Giordano, Alessandro, additional, Mauro, Ernesto di, additional, Trama, Francesco, additional, Amicuzi, Ugo, additional, Arcaniolo, Davide, additional, Fusco, Ferdinando, additional, and Longo, Nicola, additional

Published
2022
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26. Metastasis-Directed Radiation Therapy with Consolidative Intent for Oligometastatic Urothelial Carcinoma: A Systematic Review and Meta-Analysis

Author

Longo, Nicola, primary, Celentano, Giuseppe, additional, Napolitano, Luigi, additional, La Rocca, Roberto, additional, Capece, Marco, additional, Califano, Gianluigi, additional, Collà Ruvolo, Claudia, additional, Mangiapia, Francesco, additional, Fusco, Ferdinando, additional, Morra, Simone, additional, Turco, Carmine, additional, Di Bello, Francesco, additional, Fusco, Giovanni Maria, additional, Cirillo, Luigi, additional, Cacciapuoti, Crescenzo, additional, Spirito, Lorenzo, additional, Calogero, Armando, additional, Sica, Antonello, additional, Sagnelli, Caterina, additional, and Creta, Massimiliano, additional

Published
2022
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27. Lower urinary tract symptoms and mental health during COVID-19 pandemic

Author

Barone, Biagio, primary, De Luca, Luigi, additional, Napolitano, Luigi, additional, Reccia, Pasquale, additional, Crocetto, Felice, additional, Creta, Massimiliano, additional, Vitale, Raffaele, additional, Caputo, Vincenzo Francesco, additional, Martino, Raffaele, additional, Cirillo, Luigi, additional, Fusco, Giovanni Maria, additional, Trivellato, Massimiliano, additional, Celentano, Giuseppe, additional, La Rocca, Roberto, additional, Prezioso, Domenico, additional, and Longo, Nicola, additional

Published
2022
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28. The Role of Testosterone in the Elderly: What Do We Know?

Author

Barone, Biagio, primary, Napolitano, Luigi, additional, Abate, Marco, additional, Cirillo, Luigi, additional, Reccia, Pasquale, additional, Passaro, Francesco, additional, Turco, Carmine, additional, Morra, Simone, additional, Mastrangelo, Francesco, additional, Scarpato, Antonio, additional, Amicuzi, Ugo, additional, Morgera, Vincenzo, additional, Romano, Lorenzo, additional, Calace, Francesco Paolo, additional, Pandolfo, Savio Domenico, additional, De Luca, Luigi, additional, Aveta, Achille, additional, Sicignano, Enrico, additional, Trivellato, Massimiliano, additional, Spena, Gianluca, additional, D’Alterio, Carlo, additional, Fusco, Giovanni Maria, additional, Vitale, Raffaele, additional, Arcaniolo, Davide, additional, and Crocetto, Felice, additional

Published
2022
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29. Telementoring for communication between residents and faculty physicians: Results from a survey on attitudes and perceptions in an Academic Tertiary Urology Referral Department in Italy

Author

Mirone, Vincenzo, primary, Creta, Massimiliano, additional, Capece, Marco, additional, Celentano, Giuseppe, additional, Califano, Gianluigi, additional, Collà Ruvolo, Claudia, additional, Spirito, Lorenzo, additional, Fusco, Giovanni Maria, additional, Cirillo, Luigi, additional, Longo, Nicola, additional, Fusco, Ferdinando, additional, Mirone, Claudia, additional, La Rocca, Roberto, additional, and Napolitano, Luigi, additional

Published
2021
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30. Impact of Circadian Desynchrony on Spermatogenesis: A Mini Review

Author

Fusco, Ferdinando, primary, Longo, Nicola, additional, De Sio, Marco, additional, Arcaniolo, Davide, additional, Celentano, Giuseppe, additional, Capece, Marco, additional, La Rocca, Roberto, additional, Mangiapia, Francesco, additional, Califano, Gianluigi, additional, Morra, Simone, additional, Turco, Carmine, additional, Spena, Gianluca, additional, Spirito, Lorenzo, additional, Fusco, Giovanni Maria, additional, Cirillo, Luigi, additional, De Luca, Luigi, additional, Napolitano, Luigi, additional, Mirone, Vincenzo, additional, and Creta, Massimiliano, additional

Published
2021
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32. Oral Preparation of Hyaluronic Acid, Chondroitin Sulfate, Curcumin, and Quercetin (Ialuril ® Soft Gels) for the Prevention of LUTS after Intravesical Chemotherapy.

Author

Manfredi, Celeste, Spirito, Lorenzo, Calace, Francesco Paolo, Balsamo, Raffaele, Terribile, Marco, Stizzo, Marco, Romano, Lorenzo, Napolitano, Luigi, Califano, Gianluigi, Cirillo, Luigi, Fusco, Giovanni Maria, Rosati, Claudia, Quattrone, Carmelo, Sciorio, Carmine, Creta, Massimiliano, Longo, Nicola, De Sio, Marco, and Arcaniolo, Davide

Subjects
QUERCETIN, HYALURONIC acid, CHONDROITIN sulfates, ORAL drug administration, CURCUMIN, CANCER chemotherapy, MITOMYCIN C
Abstract

Intravesical chemotherapy may cause chemical cystitis and related lower urinary tract symptoms (LUTS). The aims of this study were to evaluate the efficacy and safety of an oral preparation of hyaluronic acid (HA), chondroitin sulfate (CS), curcumin, and quercetin (Ialuril® Soft Gels) to reduce the severity of LUTS in patients with a history of bladder cancer (BCa) undergoing intravesical chemotherapy. We designed a monocentric, randomized, double-blind, placebo-controlled pilot trial. Patients referred to our institute between November 2016 and March 2018 were enrolled. All subjects had non-muscle-invasive BCa and received intravesical chemotherapy with mitomycin C (MMC). Patients were randomized 1:1 in two groups (intervention vs. control). All subjects underwent oral administration (Ialuril® Soft Gels or placebo) starting one week before the first weekly instillation and ending 30 days after the last one, subsequently starting one week before each monthly instillation and ending 14 days after it. International prostate symptom score (IPSS) and 0-100 visual analogue scale (VAS) were used to assess the efficacy of the treatment. Adverse events were also described. Patients were evaluated at baseline and after 1, 4, 7, and 13 months of intravesical chemotherapy. A total of 34 patients were enrolled. The median IPSS score was significantly lower in the intervention group compared to the control group at 4 (13 vs. 17 points; p = 0.038), 7 (10 vs. 18 points; p < 0.001), and 13 (10 vs. 17 points; p = 0.002) months. The median VAS score was significantly lower in the intervention group compared to the control group at 7 (22 vs. 37 points; p = 0.021) and 13 (20 vs. 35 points; p = 0.024) months. No AE specifically related to supplement or placebo was recorded. Oral formulation of HA, CS, quercetin, and curcumin could be an effective and safe supportive therapy against chemical cystitis in patients receiving intravesical chemotherapy for BCa. [ABSTRACT FROM AUTHOR]

Published
2022
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33. Abnormal presentation of a bilateral, synchronous and plurimetastatic medium and large cell testicular lymphoma: A case report.

Author

Di Domenico, Dante, Barone, Biagio, Del Biondo, Dario, Napolitano, Luigi, Fusco, Giovanni Maria, Cirillo, Luigi, Reccia, Pasquale, De Luca, Luigi, Zito, Aniello Rosario, Napodano, Giorgio, Amato, Carmen, Stanislao, Irene, Viscusi, Vincenzo, and Crocetto, Felice

Subjects
TESTICULAR cancer, NON-Hodgkin's lymphoma, LYMPHOMAS, SYMPTOMS, COMPUTED tomography, IMPOTENCE
Abstract

Primary testicular lymphoma (PTL) accounts for 1-2% of all cases of non-Hodgkin's lymphoma, with a higher incidence in patients aged >60 years. The most common histological subtype is diffuse large-cell B lymphoma. By contrast, the bilateral synchronous and multimetastatic clinical presentation is a rare and unusual clinical presentation. In testicular masses, orchiectomy is essential for histopathological evaluation of the disease and definition of the immunophenotypic structure. The present study reported the case of a paucisymptomatic 54-year-old patient, who presented with erectile dysfunction and increasing testicular volume. Although clinical assessment and ultrasound examination showed an abnormal structure, highly suspicious for testicular cancer, the subsequent bilateral radical orchiectomy permitted the diagnosis of an unusual and rare PTL with multiple metastases reported at the PET/CT scan. In conclusion, the rare and aggressive disease represented by PTL requires a multidisciplinary approach and an aggressive treatment in order to provide the best care for patients affected. [ABSTRACT FROM AUTHOR]

Published
2022
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34. Cytoreductive Nephrectomy and Metastatic Renal Cell Carcinoma: State of the Art and Future Perspectives

Author

Luigi Napolitano, Celeste Manfredi, Luigi Cirillo, Giovanni Maria Fusco, Francesco Passaro, Marco Abate, Roberto La Rocca, Francesco Mastrangelo, Lorenzo Spirito, Savio Domenico Pandolfo, Felice Crocetto, Davide Arcaniolo, Biagio Barone, Napolitano, Luigi, Manfredi, Celeste, Cirillo, Luigi, Fusco, Giovanni Maria, Passaro, Francesco, Abate, Marco, La Rocca, Roberto, Mastrangelo, Francesco, Spirito, Lorenzo, Pandolfo, Savio Domenico, Crocetto, Felice, Arcaniolo, Davide, and Barone, Biagio

Subjects
renal cell carcinoma, target therapy, General Medicine, metastatic renal cell carcinoma, cytoreductive nephrectomy
Abstract

In the past decades, several treatments have been proposed for the management of metastatic renal cell carcinoma (mRCC). Among these, cytoreductive nephrectomy (CN) represents a controversial and open issue in the era of targeted therapy and novel immunotherapy with immune checkpoint inhibitors. Two important studies, CARMENA and SURTIME, analyzed therapy with sunitinib with or without CN, and immediate CN followed by sunitinib versus a deferred CN after three cycles of sunitinib, respectively. CARMENA showed the non-inferiority of sunitinib alone versus sunitinib plus CN, whereas SURTIME showed no difference in progression-free survival (PFS), but a better median OS among patients with deferred CN. Therefore, more prospective clinical trials and appropriate patient identification are necessary to support CN in this new scenario. This review provides a snapshot of the current evidence for CN in mRCC, discusses the management strategies, and offers perspectives on the direction of future research.

Published
2023

35. Abnormal presentation of a bilateral, synchronous and plurimetastatic medium and large cell testicular lymphoma: A case report

Author

Dante Di Domenico, Biagio Barone, Dario Del Biondo, Luigi Napolitano, Giovanni Fusco, Luigi Cirillo, Pasquale Reccia, Luigi De Luca, Aniello Zito, Giorgio Napodano, Carmen Amato, Irene Stanislao, Vincenzo Viscusi, Felice Crocetto, Di Domenico, Dante, Barone, Biagio, Del Biondo, Dario, Napolitano, Luigi, Fusco, Giovanni Maria, Cirillo, Luigi, Reccia, Pasquale, De Luca, Luigi, Zito, Aniello Rosario, Napodano, Giorgio, Amato, Carmen, Stanislao, Irene, Viscusi, Vincenzo, and Crocetto, Felice

Subjects
Cancer Research, Oncology, case report, lymphoma, bilateral, metastatic, testicular cancer
Abstract

Primary testicular lymphoma (PTL) accounts for 1-2% of all cases of non-Hodgkin's lymphoma, with a higher incidence in patients aged >60 years. The most common histological subtype is diffuse large-cell B lymphoma. By contrast, the bilateral synchronous and multimetastatic clinical presentation is a rare and unusual clinical presentation. In testicular masses, orchiectomy is essential for histopathological evaluation of the disease and definition of the immunophenotypic structure. The present study reported the case of a paucisymptomatic 54-year-old patient, who presented with erectile dysfunction and increasing testicular volume. Although clinical assessment and ultrasound examination showed an abnormal structure, highly suspicious for testicular cancer, the subsequent bilateral radical orchiectomy permitted the diagnosis of an unusual and rare PTL with multiple metastases reported at the PET/CT scan. In conclusion, the rare and aggressive disease represented by PTL requires a multidisciplinary approach and an aggressive treatment in order to provide the best care for patients affected.

Published
2022
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36. Male Sexual Dysfunction and Infertility in Spinal Cord Injury Patients: State-of-the-Art and Future Perspectives

Author

Francesco Di Bello, Massimiliano Creta, Luigi Napolitano, Gianluigi Califano, Francesco Passaro, Simone Morra, Angelo di Giovanni, Giovanni Maria Fusco, Luigi Cirillo, Marco Abate, Vincenzo Morgera, Gianluigi Cacace, Luigi De Luca, Gianluca Spena, Claudia Collà Ruvolo, Francesco Paolo Calace, Celeste Manfredi, Roberto La Rocca, Giuseppe Celentano, Carmine Turco, Marco Capece, Carlo D’Alterio, Alessandro Giordano, Ernesto di Mauro, Francesco Trama, Ugo Amicuzi, Davide Arcaniolo, Ferdinando Fusco, Nicola Longo, Di Bello, F, Creta, M, Napolitano, L, Califano, G, Passaro, F, Morra, S, Giovanni, Ad, Fusco, Gm, Cirillo, L, Abate, M, Morgera, V, Cacace, G, De Luca, L, Spena, G, Collà Ruvolo, C, Calace, Fp, Manfredi, C, La Rocca, R, Celentano, G, Turco, C, Capece, M, D'Alterio, C, Giordano, A, Mauro, Ed, Trama, F, Amicuzi, U, Arcaniolo, D, Fusco, F, Longo, N, Di Bello, Francesco, Creta, Massimiliano, Napolitano, Luigi, Califano, Gianluigi, Passaro, Francesco, Morra, Simone, Giovanni, Angelo di, Fusco, Giovanni Maria, Cirillo, Luigi, Abate, Marco, Morgera, Vincenzo, Cacace, Gianluigi, De Luca, Luigi, Spena, Gianluca, Collà Ruvolo, Claudia, Calace, Francesco Paolo, Manfredi, Celeste, La Rocca, Roberto, Celentano, Giuseppe, Turco, Carmine, Capece, Marco, D’Alterio, Carlo, Giordano, Alessandro, Mauro, Ernesto di, Trama, Francesco, Amicuzi, Ugo, Arcaniolo, Davide, Fusco, Ferdinando, and Longo, Nicola

Subjects
andrology, spinal cord injury, male infertility, sexual dysfunction, erectile dysfunction, pathophysiology, personalized treatment, Medicine (miscellaneous)
Abstract

Spinal cord injury (SCI) is a relevant medical and social problem. According to the World Health Organization, the commonly estimated worldwide annual incidence of SCI is 40 to 80 cases per million population. After the SCI experience, most men present with sexual dysfunction (erectile dysfunction (ED) and ejaculatory dysfunction), fertility problems (such as impaired spermatogenesis, abnormalities in sperm viability, motility, and morphology), and systemic disorders such as genitourinary infection and endocrine imbalances. The best options available for managing the ejaculatory disorders in patients suffering from SCI are penile vibratory stimulation (PVS) and electroejaculation (EEJ). Furthermore, the treatment of ED in SCI patients consists of medical therapies including phosphodiesterase 5 inhibitors (PDE5i), intracavernosal injections (ICI), vacuum erection devices (VEDs), and surgical as penile prosthesis (PP). This review provides a snapshot of the current evidence for the mechanisms of sexual dysfunction and infertility in SCI patients, discusses the best management strategies for these conditions, and offers our perspective on the direction of future research.

Published
2022

37. Male infertility, what Mobile Health Applications 'know': quality analysis and adherence to European Association of Urology Guidelines

Author

Giovanni Maria Fusco, Luigi Cirillo, Marco Abate, Simone Morra, Vincenzo Morgera, Biagio Barone, Felice Crocetto, Gianluigi Cacace, Francesco Di Bello, Lorenzo Spirito, Celeste Manfredi, Davide Arcaniolo, Alessandro Palmieri, Ciro Imbimbo, Vincenzo Mirone, Luigi Napolitano, Fusco, Giovanni Maria, Cirillo, Luigi, Abate, Marco, Morra, Simone, Morgera, Vincenzo, Barone, Biagio, Crocetto, Felice, Cacace, Gianluigi, Di Bello, Francesco, Spirito, Lorenzo, Manfredi, Celeste, Arcaniolo, Davide, Palmieri, Alessandro, Imbimbo, Ciro, Mirone, Vincenzo, and Napolitano, Luigi

Subjects
Urology
Abstract

Introduction: Male infertility (MI) is one of the most important worrying topics for the fertile age population. Nowadays, several mobile health applications (MHAs) have been developed to help and assist patients suffering from male infertility (MI), but their quality and adherence to the guidelines is not solved issue yet. Materials and methods: On 2nd July 2022, an observational cross-sectional descriptive study of all MHAs on male infertility was conducted: a search on both the iTunes App Store and Google Play Store was performed. Our group reviewed all MHAs, evaluating the quality, using Mobile Application Rating Scale (MARS), and the adherence to European Association of Urology guidelines, with a special tool created for this manuscript. Results: In the final analysis we included 10 MHAs: 20% (n = 2) from the iTunes App Store and 80% (n = 8) from the Google Play Store. Across the sample, 80% (n = 8) of the apps provided general information on MI, 60% (n = 6) focused on diagnosis and 50% (n = 5) focused on treatment options, respectively. According to MARS tool, the mean score was 2.18 (0.78), 3.78 (0.36), 3.0 (0.53), 3.19 (0.45), 2.18 (0.54) for Engagement, Functionality, Aesthetic, Information and Subjective quality, respectively. According to EAU Adherence Score, the highest score was reported by “Infertilità” with 12/15 points while the lowest score was reported by “Fertility Diet Guide”, 0/15 points. Conclusions: Nowadays, MHAs present in the market are not a reliable source of information on MI. An ideal MHAs should be based on scientific evidence, user friendly, respecting privacy and security laws, making patients feel capable and confident to change personal behavior or attitudes.

Published
2022

38. Perceptions and attitudes toward the use of telemedicine for the postoperative outpatient urological care during the COVID-19 pandemic in an Academic Hospital in Southern Italy

Author

Vincenzo Mirone, Giuseppe Celentano, Claudia Collà Ruvolo, Luigi Cirillo, Giovanni Maria Fusco, Marco Abate, Simone Morra, Francesco Di Bello, Gianluigi Califano, Claudia Mirone, Gianluigi Cacace, Vincenzo Morgera, Roberto La Rocca, Marco Capece, Nicola Longo, Luigi Napolitano, Massimiliano Creta, Mirone, Vincenzo, Celentano, Giuseppe, Collà Ruvolo, Claudia, Cirillo, Luigi, Fusco, Giovanni Maria, Abate, Marco, Morra, Simone, Di Bello, Francesco, Califano, Gianluigi, Mirone, Claudia, Cacace, Gianluigi, Morgera, Vincenzo, La Rocca, Roberto, Capece, Marco, Longo, Nicola, Napolitano, Luigi, and Creta, Massimiliano

Subjects
Italy, SARS-CoV-2, Patient Satisfaction, Urology, Outpatients, Humans, COVID-19, Pandemics, Telemedicine, Hospitals
Abstract

Introduction: Telemedicine is a most used tools in various medical and surgical scenarios. The aim of the present study was to explore attitudes and perceptions by urologic patients toward the use of telemedicine in the context of patient-physicians communication during the post-operative follow-up in a large academic tertiary urology referral department in Italy. Materials and methods: An anonymous questionnaire consisting of 15 multiple choice questions was designed including three sections: respondents’ demographics, attitudes, and perceptions towards the use of telemedicine. Invitations to participate to this anonymous questionnaire was given to outpatients attended at Urology Department, University of Naples Federico II. Results: In total 697 responses were received (participation rate 73%). The frequency of telemedicine use was described as frequently, occasional, rarely, and never by 41.6%, 30.4%, 15.1%, and 12.6% of respondents, respectively. WhatsApp messenger used by 59.5% of respondents and telephone call (34.3%) were the most common type of tools. Satisfaction in using telemedicine was reported as very satisfied, satisfied, neutral, dissatisfied, and very dissatisfied by 39.6%,41.4%,10%,7% and 2% of respondents respectively. Overall, 43.7%% of participants individuated limited interaction and risk of misdiagnosis as the major limit of telemedicine. Conclusions: Telemedicine represents the future of medical practice due to several benefits as well as convenience, increased access to care and decreased healthcare costs.

Published
2022

39. Impact of Circadian Desynchrony on Spermatogenesis: A Mini Review

Author

Ferdinando Fusco, Nicola Longo, Marco De Sio, Davide Arcaniolo, Giuseppe Celentano, Marco Capece, Roberto La Rocca, Francesco Mangiapia, Gianluigi Califano, Simone Morra, Carmine Turco, Gianluca Spena, Lorenzo Spirito, Giovanni Maria Fusco, Luigi Cirillo, Luigi De Luca, Luigi Napolitano, Vincenzo Mirone, Massimiliano Creta, Fusco, Ferdinando, Longo, Nicola, De Sio, Marco, Arcaniolo, Davide, Celentano, Giuseppe, Capece, Marco, La Rocca, Roberto, Mangiapia, Francesco, Califano, Gianluigi, Morra, Simone, Turco, Carmine, Spena, Gianluca, Spirito, Lorenzo, Fusco, Giovanni Maria, Cirillo, Luigi, De Luca, Luigi, Napolitano, Luigi, Mirone, Vincenzo, Creta, Massimiliano, Fusco, F., Longo, N., De Sio, M., Arcaniolo, D., Celentano, G., Capece, M., La Rocca, R., Mangiapia, F., Califano, G., Morra, S., Turco, C., Spena, G., Spirito, L., Fusco, G. M., Cirillo, L., De Luca, L., Napolitano, L., Mirone, V., and Creta, M.

Subjects
Male, circadian rhythm, fertility, Mini Review, Endocrinology, Diabetes and Metabolism, clock gene, circadian desynchrony, Chronobiology Disorders, RC648-665, spermatogenesis, Diseases of the endocrine glands. Clinical endocrinology, circadian desynchrony, circadian rhythms, clock genes, spermatogenesis, fertility, Semen Analysis, Endocrinology, circadian rhythms, clock genes, Animals, Humans, Gonadal Steroid Hormones, Infertility, Male
Abstract

The purpose of this mini review is to provide data about pre-clinical and clinical evidence exploring the impact of circadian desynchrony on spermatogenesis. Several lines of evidence exist demonstrating that disruption of circadian rhythms may interfere with male fertility. Experimental knock-out or knock-down of clock genes, physiologically involved in the regulation of circadian rhythms, are associated with impairments of fertility pathways in both animal and human models. Moreover, disruption of circadian rhythms, due to reduction of sleep duration and/or alteration of its architecture can negatively interfere in humans with circulating levels of male sexual hormones as well as with semen parameters. Unfortunately, current evidence remains low due to study heterogeneity.

Published
2021
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