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1. Clinical and laboratory predictors of mpox severity and duration: an Italian multicentre cohort study (mpox-Icona)

Author

Antinori, Andrea, Antinori, Spinello, Baiguera, Chiara, Baldin, Gianmaria, Bassetti, Matteo, Biasioli, Lorenzo, Bonfanti, Paolo, Brucci, Giorgia, Bruzzesi, Elena, Candela, Caterina, Cascio, Antonio, Castagna, Antonella, Monforte, Antonella d'Arminio, Delama, Andrea, D'Ettorre, Gabriella, Farinacci, Damiano, Fusco, Francesco Maria, Gismondo, Maria Rita, Gori, Andrea, Lanini, Simone, Lanzafame, Massimiliano, Lapadula, Giuseppe, Lichtner, Miriam, Maci, Chiara, Mancarella, Giulia, Mancon, Alessandro, Marchetti, Giulia, Matusali, Giulia, Mazzotta, Valentina, Nicastri, Emanuele, Nozza, Silvia, Pandolfo, Alessandro, Panzo, Francesca, Piconi, Stefania, Pinnetti, Carmela, Pipitò, Luca, Raccagni, Angelo Roberto, Raimondi, Alessandro, Ridolfi, Marco, Rizzardini, Giuliano, Rodanò, Alessandra, Rossotti, Roberto, Sambo, Margherita, Sangiovanni, Vincenzo, Sangiovanni, Nadia, Tamburrini, Enrica, Tavelli, Alessandro, Tesoro, Daniele, Vita, Serena, Moschese, Davide, Mileto, Davide, Di Biagio, Antonio, and Monforte, Antonella d’Arminio

Published
2024
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3. Risk of COVID-19 in-hospital mortality in people living with HIV compared to general population according to age and CD4 strata: data from the ICONA network

Author

Giacomelli, Andrea, Gagliardini, Roberta, Tavelli, Alessandro, De Benedittis, Sara, Mazzotta, Valentina, Rizzardini, Giuliano, Mondi, Annalisa, Augello, Matteo, Antinori, Spinello, Vergori, Alessandra, Gori, Andrea, Menozzi, Marianna, Taramasso, Lucia, Fusco, Francesco Maria, De Vito, Andrea, Mancarella, Giulia, Marchetti, Giulia, D'Arminio Monforte, Antonella, Antinori, Andrea, and Cozzi-Lepri, Alessandro

Published
2023
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4. FRI-442 Disease progression and persistent alanine aminotransferase elevation in HCV/HIV persons after DAA-related eradication: role of HBV and HDV co-infections

Author

Rossotti, Roberto, primary, Tavelli, Alessandro, additional, Malagnino, Vincenzo, additional, Svicher, Valentina, additional, Quiros-Roldan, Eugenia, additional, Bandera, Alessandra, additional, Fusco, Francesco Maria, additional, Capparuccia, Marco Rivano, additional, Gaeta, Giovanni Battista, additional, Mazzotta, Valentina, additional, Puoti, Massimo, additional, and Monforte, Antonella D'Arminio, additional

Published
2024
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5. The World Health Organization Pandemic Agreement draft: Considerations by the ESCMID Emerging Infections Task Force (EITaF)

Author

Granata, Guido, primary, Astorri, Roberta, additional, Broens, Els M., additional, Callaby, Helen, additional, Cunha, Flávia, additional, Di Caro, Antonino, additional, Fusco, Francesco Maria, additional, Greub, Gilbert, additional, Grobusch, Martin P., additional, Koopmans, Marion, additional, Pereira do Vale, Ana, additional, Pisapia, Raffaella, additional, Rovers, Chantal P., additional, Tostmann, Alma, additional, Tunali, Varol, additional, de Valdoleiros, Sofia R., additional, and Petersen, Eskild, additional

Published
2024
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6. Parietal intrahemispheric source connectivity of resting-state electroencephalographic alpha rhythms is abnormal in Naïve HIV patients

Author

Babiloni, Claudio, Del Percio, Claudio, Lizio, Roberta, Lopez, Susanna, Pennica, Alfredo, Roma, Paolo, Correr, Valentina, Cucciolla, Federica, Toma, Ginevra, Soricelli, Andrea, Di Campli, Francesco, Aceti, Antonio, Teti, Elisabetta, Sarmati, Loredana, Crocetti, Gloria, Ferri, Raffaele, Lorenzo, Ivan, Galli, Massimo, Negri, Cristina, Angarano, Gioacchino, Saracino, Annalisa, Lepore, Luciana, Di Pietro, Massimo, Fusco, Francesco Maria, Vullo, Vincenzo, D’Ettorre, Gabriella, Pagliano, Pasquale, Di Flumeri, Giusy, Celesia, Benedetto Maurizio, Gentilini Cacciola, Elio, Di Perri, Giovanni, Calcagno, Andrea, Stocchi, Fabrizio, Ferracuti, Stefano, Onorati, Paolo, Andreoni, Massimo, and Noce, Giuseppe

Published
2022
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7. Predictors of Mortality and Orotracheal Intubation in Patients with Pulmonary Barotrauma Due to COVID-19: An Italian Multicenter Observational Study during Two Years of the Pandemic

Author

Tetaj, Nardi, primary, De Pascale, Gennaro, additional, Antonelli, Massimo, additional, Vargas, Joel, additional, Savino, Martina, additional, Pugliese, Francesco, additional, Alessandri, Francesco, additional, Giordano, Giovanni, additional, Tozzi, Pierfrancesco, additional, Rocco, Monica, additional, Biava, Anna Maria, additional, Maggi, Luigi, additional, Pisapia, Raffaella, additional, Fusco, Francesco Maria, additional, Stazi, Giulia Valeria, additional, Garotto, Gabriele, additional, Marini, Maria Cristina, additional, Piselli, Pierluca, additional, Beccacece, Alessia, additional, Mariano, Andrea, additional, Giancola, Maria Letizia, additional, Ianniello, Stefania, additional, Vaia, Francesco, additional, Girardi, Enrico, additional, Antinori, Andrea, additional, Bocci, Maria Grazia, additional, Marchioni, Luisa, additional, and Nicastri, Emanuele, additional

Published
2024
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8. Use of hydroxychloroquine in hospitalised COVID-19 patients is associated with reduced mortality: Findings from the observational multicentre Italian CORIST study

Author

Castelnuovo, Augusto Di, Costanzo, Simona, Antinori, Andrea, Berselli, Nausicaa, Blandi, Lorenzo, Bruno, Raffaele, Cauda, Roberto, Guaraldi, Giovanni, Menicanti, Lorenzo, My, Ilaria, Parruti, Giustino, Patti, Giuseppe, Perlini, Stefano, Santilli, Francesca, Signorelli, Carlo, Spinoni, Enrico, Stefanini, Giulio G., Vergori, Alessandra, Ageno, Walter, Agodi, Antonella, Aiello, Luca, Agostoni, Piergiuseppe, Moghazi, Samir Al, Astuto, Marinella, Aucella, Filippo, Barbieri, Greta, Bartoloni, Alessandro, Bonaccio, Marialaura, Bonfanti, Paolo, Cacciatore, Francesco, Caiano, Lucia, Cannata, Francesco, Carrozzi, Laura, Cascio, Antonio, Ciccullo, Arturo, Cingolani, Antonella, Cipollone, Francesco, Colomba, Claudia, Crosta, Francesca, Pra, Chiara Dal, Danzi, Gian Battista, D'Ardes, Damiano, Donati, Katleen de Gaetano, Giacomo, Paola Del, Gennaro, Francesco Di, Di Tano, Giuseppe, D'Offizi, Giampiero, Filippini, Tommaso, Fusco, Francesco Maria, Gentile, Ivan, Gialluisi, Alessandro, Gini, Giancarlo, Grandone, Elvira, Grisafi, Leonardo, Guarnieri, Gabriella, Lamonica, Silvia, Landi, Francesco, Leone, Armando, Maccagni, Gloria, Maccarella, Sandro, Madaro, Andrea, Mapelli, Massimo, Maragna, Riccardo, Marra, Lorenzo, Maresca, Giulio, Marotta, Claudia, Mastroianni, Franco, Mazzitelli, Maria, Mengozzi, Alessandro, Menichetti, Francesco, Meschiari, Marianna, Minutolo, Filippo, Montineri, Arturo, Mussinelli, Roberta, Mussini, Cristina, Musso, Maria, Odone, Anna, Olivieri, Marco, Pasi, Emanuela, Petri, Francesco, Pinchera, Biagio, Pivato, Carlo A., Poletti, Venerino, Ravaglia, Claudia, Rinaldi, Massimo, Rognoni, Andrea, Rossato, Marco, Rossi, Ilaria, Rossi, Marianna, Sabena, Anna, Salinaro, Francesco, Sangiovanni, Vincenzo, Sanrocco, Carlo, Scorzolini, Laura, Sgariglia, Raffaella, Simeone, Paola Giustina, Spinicci, Michele, Trecarichi, Enrico Maria, Venezia, Amedeo, Veronesi, Giovanni, Vettor, Roberto, Vianello, Andrea, Vinceti, Marco, Vocciante, Laura, De Caterina, Raffaele, and Iacoviello, Licia

Published
2020
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9. RAAS inhibitors are not associated with mortality in COVID-19 patients: Findings from an observational multicenter study in Italy and a meta-analysis of 19 studies

Author

Di Castelnuovo, Augusto, Costanzo, Simona, Antinori, Andrea, Berselli, Nausicaa, Blandi, Lorenzo, Bonaccio, Marialaura, Cauda, Roberto, Gialluisi, Alessandro, Guaraldi, Giovanni, Menicanti, Lorenzo, Mennuni, Marco, Mussinelli, Roberta, My, Ilaria, Parruti, Giustino, Patti, Giuseppe, Perlini, Stefano, Santilli, Francesca, Signorelli, Carlo, Stefanini, Giulio G., Vergori, Alessandra, Abete, Pasquale, Ageno, Walter, Agostoni, Piergiuseppe, Aiello, Luca, Al Moghazi, Samir, Arboretti, Rosa, Aucella, Filippo, Barbieri, Greta, Barchitta, Martina, Bartoloni, Alessandro, Bonfanti, Paolo, Cacciatore, Francesco, Caiano, Lucia, Carrozzi, Laura, Cascio, Antonio, Castiglione, Giacomo, Cianfrone, Stefania, Ciccullo, Arturo, Cingolani, Antonella, Cipollone, Francesco, Colomba, Claudia, Colombo, Crizia, Cozzi, Ottavia, Crisetti, Annalisa, Crosta, Francesca, Danzi, Gian Battista, D'Ardes, Damiano, de Gaetano Donati, Katleen, Di Gennaro, Francesco, Di Tano, Giuseppe, D'Offizi, Gianpiero, Fusco, Francesco Maria, Gentile, Ivan, Graziani, Emauele, Guarnieri, Gabriella, Larizza, Giovanni, Leone, Armando, Lio, Veronica, Lucia, Mothanje Barbara, Maccagni, Gloria, Madaro, Ferruccio, Maitan, Stefano, Mancarella, Sandro, Manuele, Rosa, Mapelli, Massimo, Maragna, Riccardo, Marcucci, Rossella, Maresca, Giulio, Marongiu, Silvia, Marotta, Claudia, Marra, Lorenzo, Mastroianni, Franco, Mazzitelli, Maria, Mengozzi, Alessandro, Menichetti, Francesco, Meschiari, Marianna, Milic, Jovana, Minutolo, Filippo, Molena, Beatrice, Mussini, Cristina, Musso, Maria, Odone, Anna, Olivieri, Marco, Palimodde, Antonella, Pasi, Emanuela, Pesavento, Raffaele, Petri, Francesco, Pinchera, Biagio, Pivato, Carlo A., Poletti, Venerino, Ravaglia, Claudia, Rossato, Marco, Rossi, Marianna, Sabena, Anna, Salinaro, Francesco, Sangiovanni, Vincenzo, Sanrocco, Carlo, Scoppettuolo, Giancarlo, Scorzolini, Laura, Sgariglia, Raffaella, Simeone, Paola Giustina, Trecarichi, Enrico Maria, Vettor, Roberto, Vianello, Andrea, Vinceti, Marco, Virano, Alexandra, Vocciante, Laura, De Caterina, Raffaele, and Iacoviello, Licia

Published
2020
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10. Long-term outcomes of bictegravir/emtricitabine/tenofovir alafenamide as first-line therapy and as switch strategy in virologically suppressed persons with HIV: data from the ICONA cohort.

Author

Monforte, Antonella d'Arminio, Tavelli, Alessandro, Biagio, Antonio Di, Sarmati, Loredana, Marchetti, Giulia C, Bai, Francesca, Cingolani, Antonella, Roldan, Eugenio Quiros, Mussini, Cristina, Lichtner, Miriam, Vergori, Alessandra, Piconi, Stefania, Orofino, Giancarlo, Fusco, Francesco Maria, Bandera, Alessandra, Nozza, Silvia, Castagna, Antonella, Antinori, Andrea, and Group, the ICONA Foundation Study

Subjects
TENOFOVIR, HIV, EMTRICITABINE, TERMINATION of treatment, HIV infections, TREATMENT failure
Abstract

Objectives To assess the effectiveness of bictegravir/emtricitabine/tenofovir alafenamide (BIC/FTC/TAF) among people poorly represented in clinical trials and potentially at higher risk of suboptimal response to ART. Methods Observational cohort study on persons with HIV (PWH) enrolled in ICONA who started BIC/FTC/TAF as initial therapy or as switching regimen while virologically suppressed. Primary endpoint was time to treatment failure (TF): new AIDS/death or virological failure (VF) or discontinuation for toxicity/failure. Secondary endpoints were time to treatment discontinuation for toxicity (TDT) and to VF. Groups of interest were those aged >50 years, female sex, and advanced HIV disease at first ART start. Probability of the events overall and according to groups and adjusted HR for every endpoint were calculated by Kaplan–Meier curves and Cox regression models. Results Nine hundred and thirty-three ART-naive and 1655 ART-experienced PWH initiated BIC/FTC/TAF. Over a median follow-up of 69.8 weeks, 89 (9.6%) PWH at their first regimen experienced TF. PWH aged >50 years had 1.83-fold (95% CI: 1.19–2.83) higher risk of TF; PWH with advanced HIV disease had 2.21-fold (95% CI: 1.53–3.82) higher risk; there were no differences in TF according to sex. Over a median follow-up of 146.3 weeks, 109 (6.6%) out of 1655 switching PWH experienced TF; no differences were found in the risk of TF, TDT and VF according to groups of interest. Conclusions Overall, BIC/FTC/TAF is well tolerated and virologically effective in the real-world scenario for ART-naive and -experienced PWH. Older ART-naive PWH and those with advanced HIV disease may respond less well as the burden of diseases might compromise treatment efficacy. [ABSTRACT FROM AUTHOR]

Published
2024
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11. Dysregulation of lipid metabolism and pathological inflammation in patients with COVID-19

Author

Caterino, Marianna, Gelzo, Monica, Sol, Stefano, Fedele, Roberta, Annunziata, Anna, Calabrese, Cecilia, Fiorentino, Giuseppe, D’Abbraccio, Maurizio, Dell’Isola, Chiara, Fusco, Francesco Maria, Parrella, Roberto, Fabbrocini, Gabriella, Gentile, Ivan, Andolfo, Immacolata, Capasso, Mario, Costanzo, Michele, Daniele, Aurora, Marchese, Emanuela, Polito, Rita, Russo, Roberta, Missero, Caterina, Ruoppolo, Margherita, and Castaldo, Giuseppe

Published
2021
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12. The world health organization pandemic agreement draft: considerations by the European Society of Clinical Microbiology and Infectious Diseases Emerging Infections Task Force

Author

Granata, Guido, Astorri, Roberta, Broens, Els M., Callaby, Helen, Cunha, Flávia, Di Caro, Antonino, Fusco, Francesco Maria, Greub, Gilbert, Grobusch, Martin P., Koopmans, Marion, Pereira do Vale, Ana, Pisapia, Raffaella, Rovers, Chantal P., Tostmann, Alma, Tunali, Varol, de Valdoleiros, Sofia R., and Petersen, Eskild

Published
2024
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15. Enabling Rapid Response to the 2014–2016 Ebola Epidemic: The Experience and the Results of the National Institute for Infectious Diseases Lazzaro Spallanzani

Author

Nicastri, Emanuele, Castilletti, Concetta, Biava, Mirella, Fusco, Francesco Maria, Petrosillo, Nicola, Puro, Vincenzo, Lauria, Francesco Nicola, Capobianchi, Maria Rosaria, Di Caro, Antonino, Ippolito, Giuseppe, COHEN, IRUN R., Series editor, LAJTHA, ABEL, Series editor, LAMBRIS, JOHN D., Series editor, PAOLETTI, RODOLFO, Series editor, Rezza, Giovanni, editor, and Ippolito, Giuseppe, editor

Published
2017
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16. Limited Weight Impact After Switching From Boosted Protease Inhibitors to Dolutegravir in Persons With Human Immunodeficiency Virus With High Cardiovascular Risk: A Post Hoc Analysis of the 96-Week NEAT-022 Randomized Trial

Author

Waters, Laura, Assoumou, Lambert, González-Cordón, Ana, Rusconi, Stefano, Domingo, Pere, Gompels, Mark, de Wit, Stephane, Raffi, François, Stephan, Christoph, Masiá, Mar, Rockstroh, Jürgen, Katlama, Christine, Behrens, Georg M N, Moyle, Graeme, Johnson, Margaret, Fox, Julie, Stellbrink, Hans-Jürgen, Guaraldi, Giovanni, Florence, Eric, Esser, Stefan, Gatell, José M, Pozniak, Anton, Martínez, Esteban, Vandekerckhove, Linos, Caluwé, Els, Necsoi, Coca, Frankenhuijsen, Maartje Van, Allavena, Clotilde, Reliquet, Véronique, Boutoille, David, Cavellec, Morane, André-Garnier, Elisabeth, Rodallec, Audrey, Tourneau, Thierry Le, Connault, Jérôme, Molina, Jean-Michel, Ferret, Samuel, Previlon, Miresta, Yazdanpanah, Yazdan, Landman, Roland, Joly, Véronique, Pinto, Adriana, Caby, Fabienne, Ktorza, Nadine, Schneider, Luminita, Wolf, Timo, Schüttfort, Gundolf, Wasmuth, Jan-Christian, Schwarze-Zander, Carolynne, Boesecke, Christoph, Hoffmann, Christian, Sabranski, Michael, Esser, Stephan, Jablonka, Robert, Wiehler, Heidi, Stoll, Matthias, Ahrenstorf, Gerrit, Nardini, Giulia, Beghetto, Barbara, Montforte, Antonella D’Arminio, Bini, Teresa, Cogliandro, Viola, Di Pietro, Massimo, Fusco, Francesco Maria, Galli, Massimo, Giacomelli, Andrea, Meraviglia, Paola, Torres, Berta, Mateo, Gracia, Gutierrez, Mar, Portilla, Joaquin, Merino, Esperanza, Reus, Sergio, Boix, Vicente, Gutiérrez, Félix, Padilla, Sergio, Clotet, Bonaventura, Negredo, Eugenia, Bonjoch, Anna, Casado, José L, Bañón-Escandell, Sara, Saban, Jose, Duque, Africa, Podzamczer, Daniel, Saumoy, Maria, Acerete, Laura, Gonzalez-Garcia, Juan, Bernardino, José Ignacio, Arribas, José Ramón, Hontañón, Victor, Pagani, Nicole, Bracchi, Margherita, Vera, Jaime, Clarke, Amanda, Adams, Tanya, Richardson, Celia, Winston, Alan, Mora-Peris, Borja, Mullaney, Scott, Esteban, Nahum de, Milinkovic, Ana, Pett, Sarah, Tiraboschi, Juan Manuel, Youle, Mike, Orkin, Chloe, Rackstraw, Simon, Hand, James, Jennings, Louise, Nicholls, Jane, and Johnston, Sarah

Subjects
Microbiology (medical), Infectious Diseases, Medizin
Abstract

BackgroundIn the NEAT022 trial, virologically suppressed persons with human immunodeficiency virus (HIV) at high cardiovascular risk switching from protease inhibitors to dolutegravir either immediately (DTG-I) or after 48 weeks (DTG-D) showed noninferior virological suppression and significant lipid and cardiovascular disease risk reductions on switching to dolutegravir relative to continuing protease inhibitors.MethodsIn post hoc analysis, major endpoints were 48-week and 96-week weight and body mass index (BMI) changes. Factors associated with weight/BMI changes within the first 48 weeks of DTG exposure, proportion of participants by category of percentage weight change, proportions of BMI categories over time, and impact on metabolic outcomes were also assessed.ResultsBetween May 2014 and November 2015, 204 (DTG-I) and 208 (DTG-D) participants were included. Weight significantly increased (mean, +0.810 kg DTG-I arm, and +0.979 kg DTG-D arm) in the first 48 weeks postswitch, but remained stable from 48 to 96 weeks in DTG-I arm. Switching from darunavir, White race, total to high-density lipoprotein cholesterol ratio ConclusionsSwitching from protease inhibitors to dolutegravir in persons with HIV with high cardiovascular risk led to modest weight gain limited to the first 48 weeks, which involved preferentially normal-weight or underweight persons and was not associated with negative metabolic outcomes.Clinical Trials RegistrationNCT02098837 and EudraCT 2013-003704-39.

Published
2022

18. Unexpected effects of COVID-19 outbreak: adaption of Anti-Retroviral Therapy (ART) delivery policies improved adherence in a population of People Living With HIV (PLWH)

Author

Fusco, Francesco Maria, Sangiovanni, Nadia, Papa, Nunzia, Mattera Iacono, Valentina, Cuomo, Nunzia, Viglietti, Rosaria, Tambaro, Orsola, Borrelli, Francesco, Pisapia, Raffaella, Carleo, Maria Aurora, Rizzo, Viviana, Spatarella, Micaela, Esposito, Vincenzo, and Sangiovanni, Vincenzo

Subjects
Original Articles
Abstract

BACKGROUND: Adherence to Anti-Retroviral Therapy (ART) is crucial for People Living With HIV (PLWH). In Italy, ART is delivered by Hospital Pharmacies, on a renewable prescription from the hospital physician. The measurement of package-refill (the rate of ART packages actually collected out of those to be collected in order to comply with therapy) is an effective tool to evaluate the adherence. During COVID-19 outbreak, at “D. Cotugno” hospital in Naples, Italy, the ART delivery policies have been adapted, in order to reduce the number of patients’ access. We analysed the impact of these changes on the pill-refill of ART in January-August 2020, compared with 2018–2019. METHODS: “D. Cotugno” hospital is a mono-specialistic Infectious Diseases hospital, caring for about 2500 PLWH. Since February 2020, the hospital was almost entirely dedicated to COVID-19 patients. All out-patient activities were interrupted, except for those dedicated to HIV/AIDS patients. In this preliminary study we included all patients assigned to one of the three Medical Divisions dedicated to HIV, who were already under treatment since at least 2017. Rate of package-refill was obtained by the Hospital Pharmacy registry, demographic and clinical data were derived from clinical database. During COVID-19, many measures were adopted in order to increase safety of PLWH attending to hospital. Among these, medical prescription validity increased from 4 to 6 months, and number of packages to be collected increased from 2 to 4, adopting a multi-month dispensing strategy. Package-refill is adequate if at least 95% of ART have been actually collected; partial and inadequate if 75%–94% or less than 75% of ART, respectively, have been collected. Package-refill was measured during the first year of COVID-19 (March 2020 – February 2021), compared to the same period in the two years before RESULTS: A total of 594 PLWH were included. PLWH with optimal pill-refill significantly increased in 2020–21 compared to 2018–2020 (62% vs 55%, p 0.013). DISCUSSION: Due to COVID-19, we would have expected a reduction in ART deliveries. Surprisingly, the opposite occurred. The increase of pill-refill rates may be due to different reasons, but we hypothesized that the adaption of delivery policies, with a higher number of packages allowed to be collected, strongly contributed to this result. This study suggests that multi-month dispensing policies may contribute to the improvement of adherence among PLWH.

Published
2023

21. Epidemiology of HCV and HBV in a High Endemic Area of Southern Italy: Opportunities from the COVID-19 Pandemic—Standardized National Screening or One Tailored to Local Epidemiology?

Author

Nevola, Riccardo, primary, Messina, Vincenzo, additional, Marrone, Aldo, additional, Coppola, Nicola, additional, Rescigno, Carolina, additional, Esposito, Vincenzo, additional, Sangiovanni, Vincenzo, additional, Claar, Ernesto, additional, Pisaturo, Mariantonietta, additional, Fusco, Francesco Maria, additional, Rosario, Pietro, additional, Izzi, Antonio, additional, Pisapia, Raffaella, additional, Rosato, Valerio, additional, Maggi, Paolo, additional, and Adinolfi, Luigi Elio, additional

Published
2022
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22. Personal Protective Equipment Management and Policies: European Network for Highly Infectious Diseases Data from 48 Isolation Facilities in 16 European Countries

Author

De Iaco, Giuseppina, Puro, Vincenzo, Fusco, Francesco Maria, Schilling, Stefan, Maltezou, Helena C., Brouqui, Philippe, Gottschalk, René, Bannister, Barbara, Brodt, Hans-Reinhard, Siikamaki, Heli, Perronne, Christian, Brantsæter, Arne Broch, Fjellet, Anne Lise, and Ippolito, Giuseppe

Published
2012
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23. Evolving epidemiology of HIV/AIDS in Campania region, 2011–2018: Is HIV/AIDS population in Campania different?

Author

Fusco, Francesco Maria, primary, Sangiovanni, Nadia, additional, Mascolo, Silvia, additional, Carleo, Maria Aurora, additional, Sardo, Massimo, additional, Viglietti, Rosaria, additional, Parrella, Giovanni, additional, Tambaro, Orsola, additional, Iodice, Valentina, additional, Di Flumeri, Giusy, additional, Menna, Anna, additional, Galano, Assunta, additional, Laudiero, Anna, additional, Mariniello, Antonietta, additional, De Cenzo, Milena, additional, Manzillo, Elio, additional, Esposito, Vincenzo, additional, Chirianni, Antonio, additional, and Sangiovanni, Vincenzo, additional

Published
2022
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24. Enabling Rapid Response to the 2014–2016 Ebola Epidemic: The Experience and the Results of the National Institute for Infectious Diseases Lazzaro Spallanzani

Author

Nicastri, Emanuele, primary, Castilletti, Concetta, additional, Biava, Mirella, additional, Fusco, Francesco Maria, additional, Petrosillo, Nicola, additional, Puro, Vincenzo, additional, Lauria, Francesco Nicola, additional, Capobianchi, Maria Rosaria, additional, Di Caro, Antonino, additional, and Ippolito, Giuseppe, additional

Published
2016
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26. The Serum Metabolome of Moderate and Severe COVID-19 Patients Reflects Possible Liver Alterations Involving Carbon and Nitrogen Metabolism

Author

Caterino, Marianna, primary, Costanzo, Michele, additional, Fedele, Roberta, additional, Cevenini, Armando, additional, Gelzo, Monica, additional, Di Minno, Alessandro, additional, Andolfo, Immacolata, additional, Capasso, Mario, additional, Russo, Roberta, additional, Annunziata, Anna, additional, Calabrese, Cecilia, additional, Fiorentino, Giuseppe, additional, D’Abbraccio, Maurizio, additional, Dell’Isola, Chiara, additional, Fusco, Francesco Maria, additional, Parrella, Roberto, additional, Fabbrocini, Gabriella, additional, Gentile, Ivan, additional, Castaldo, Giuseppe, additional, and Ruoppolo, Margherita, additional

Published
2021
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28. Switching from boosted PIs to dolutegravir decreases soluble CD14 and adiponectin in high cardiovascular risk people living with HIV

Author

Assoumou, Lambert, Moyle, Graeme, Waters, Laura, Johnson, Margaret, Domingo, Pere, Fox, Julie, Stellbrink, Hans-Jürgen, Guaraldi, Giovanni, Masiá, Mar, Gompels, Mark, De Wit, Stephane, Florence, Eric, Esser, Stefan, Raffi, François, Behrens, Georg, Pozniak, Anton, Gatell, José M., Martínez, Esteban, Vandekerckhove, Linos, Caluwé, Els, Necsoi, Coca, Van Frankenhuijsen, Maartje, Allavena, Clotilde, Reliquet, Véronique, Boutoille, David, Cavellec, Morane, André-Garnier, Elisabeth, Rodallec, Audrey, Le Tourneau, Thierry, Connault, Jérôme, Molina, Jean-Michel, Ferret, Samuel, Previlon, Miresta, Yazdanpanah, Yazdan, Landman, Roland, Joly, Véronique, Pinto, Adriana, Katlama, Christine, Caby, Fabienne, Ktorza, Nadine, Schneider, Luminita, Stephan, Christoph, Wolf, Timo, Schüttfort, Gundolf, Rockstroh, Juergen, Wasmuth, Jan-Christian, Schwarze-Zander, Carolynne, Boesecke, Christoph, Stellbrink, Hans-Jurgen, Hoffmann, Christian, Sabranski, Michael, Jablonka, Robert, Wiehler, Heidi, Stoll, Matthias, Ahrenstorf, Gerrit, Nardini, Giulia, Beghetto, Barbara, Montforte, Antonella D'Arminio, Bini, Teresa, Cogliandro, Viola, Di Pietro, Massimo, Fusco, Francesco Maria, Galli, Massimo, Rusconi, Stefano, Giacomelli, Andrea, Meraviglia, Paola, Martinez, Esteban, González-Cordón, Ana, Gatell, José Maria, Torres, Berta, Mateo, Gracia, Gutierrez, Mar, Portilla, Joaquin, Merino, Esperanza, Reus, Sergio, Boix, Vicente, Masia, Mar, Gutiérrez, Félix, Padilla, Sergio, Clotet, Bonaventura, Negredo, Eugenia, Bonjoch, Anna, Casado, José L, Bañón-Escandell, Sara, Saban, Jose, Duque, Africa, Podzamczer, Daniel, Saumoy, Maria, Acerete, Laura, Gonzalez-Garcia, Juan, Bernardino, José Ignacio, Arribas, José Ramón, Hontañón, Victor, Pagani, Nicole, Bracchi, Margherita, Vera, Jaime, Clarke, Amanda, Adams, Tanya, Richardson, Celia, Winston, Alan, Mora-Peris, Borja, Mullaney, Scott, De Esteban, Nahum, Milinkovic, Ana, Pett, Sarah, Tiraboschi, Juan Manuel, Youle, Mike, Orkin, Chloe, Rackstraw, Simon, Hand, James, Jennings, Louise, Nicholls, Jane, Johnston, Sarah, and NEAT022 Study Grp

Subjects
Microbiology (medical), medicine.medical_specialty, Pyridones, Lipopolysaccharide Receptors, Medizin, HIV Infections, Inflammation, Piperazines, chemistry.chemical_compound, Insulin resistance, Risk Factors, Internal medicine, Oxazines, medicine, Humans, Pharmacology (medical), Endothelial dysfunction, Biology, Pharmacology, Ritonavir, biology, Adiponectin, business.industry, Pharmacology. Therapy, C-reactive protein, medicine.disease, Infectious Diseases, Endocrinology, chemistry, Cardiovascular Diseases, Heart Disease Risk Factors, Heart failure, Dolutegravir, biology.protein, Human medicine, medicine.symptom, business, Heterocyclic Compounds, 3-Ring, Weight gain
Abstract

Background Switching from boosted PIs to dolutegravir in people living with HIV (PLWH) with high cardiovascular risk improved plasma lipids at 48 weeks in the NEAT022 trial. Whether this strategy may have an impact on cardiovascular biomarkers is unknown. Methods We assessed 48 week changes in biomarkers associated with inflammation, endothelial dysfunction, monocyte immune activation, oxidation, insulin resistance, hypercoagulability, heart failure, myocardial injury, and glomerular and tubular kidney injury. Results Of 415 PLWH randomized in the NEAT022 study, 313 (75.4%) remained on allocated therapy and had paired samples available. Soluble CD14 (–11%, P Conclusions Switching from boosted PIs to dolutegravir in PLWH with high cardiovascular risk led to soluble CD14 and adiponectin reductions at 48 weeks. While decreasing soluble CD14 may entail favourable health effects in PLWH, adiponectin reduction may reflect less insulin sensitivity associated with weight gain.

Published
2021

29. Disentangling the Association of Hydroxychloroquine Treatment with Mortality in Covid-19 Hospitalized Patients through Hierarchical Clustering

Author

Di Castelnuovo, Augusto, primary, Gialluisi, Alessandro, additional, Antinori, Andrea, additional, Berselli, Nausicaa, additional, Blandi, Lorenzo, additional, Bonaccio, Marialaura, additional, Bruno, Raffaele, additional, Cauda, Roberto, additional, Costanzo, Simona, additional, Guaraldi, Giovanni, additional, Menicanti, Lorenzo, additional, Mennuni, Marco, additional, My, Ilaria, additional, Parruti, Giustino, additional, Patti, Giuseppe, additional, Perlini, Stefano, additional, Santilli, Francesca, additional, Signorelli, Carlo, additional, Stefanini, Giulio, additional, Vergori, Alessandra, additional, Ageno, Walter, additional, Agodi, Antonella, additional, Agostoni, Piergiuseppe, additional, Aiello, Luca, additional, Al Moghazi, Samir, additional, Arboretti, Rosa, additional, Aucella, Filippo, additional, Barbieri, Greta, additional, Barchitta, Martina, additional, Bonfanti, Paolo, additional, Cacciatore, Francesco, additional, Caiano, Lucia, additional, Cannata, Francesco, additional, Carrozzi, Laura, additional, Cascio, Antonio, additional, Castiglione, Giacomo, additional, Ciccullo, Arturo, additional, Cingolani, Antonella, additional, Cipollone, Francesco, additional, Colomba, Claudia, additional, Colombo, Crizia, additional, Crisetti, Annalisa, additional, Crosta, Francesca, additional, Danzi, Gian Battista, additional, D'Ardes, Damiano, additional, de Gaetano Donati, Katleen, additional, Di Gennaro, Francesco, additional, Di Tano, Giuseppe, additional, D'Offizi, Gianpiero, additional, Fusco, Francesco Maria, additional, Gaudiosi, Carlo, additional, Gentile, Ivan, additional, Gianfagna1, Francesco, additional, Giuliano, Gabriele, additional, Graziani, Emauele, additional, Guarnieri, Gabriella, additional, Langella, Valerio, additional, Larizza, Giovanni, additional, Leone, Armando, additional, Maccagni, Gloria, additional, Magni, Federica, additional, Maitan, Stefano, additional, Mancarella, Sandro, additional, Manuele, Rosa, additional, Mapelli, Massimo, additional, Maragna, Riccardo, additional, Marcucci, Rossella, additional, Maresca, Giulio, additional, Marongiu, Silvia, additional, Marotta, Claudia, additional, Marra, Lorenzo, additional, Mastroianni, Franco, additional, Mengozzi, Alessandro, additional, Meschiari, Marianna, additional, Milic, Jovana, additional, Minutolo, Filippo, additional, Mussinelli, Roberta, additional, Mussini, Cristina, additional, Musso, Maria, additional, Odone, Anna, additional, Olivieri, Marco, additional, Palimodde, Antonella, additional, Pasi, Emanuela, additional, Pesavento, Raffaele, additional, Petri, Francesco, additional, Pivato, Carlo A, additional, Poletti, Venerino, additional, Ravaglia, Claudia, additional, Righetti, Giulia, additional, Rognoni, Andrea, additional, Rossato, Marco, additional, Rossi, Ilaria, additional, Rossi, Marianna, additional, Sabena, Anna, additional, Salinaro, Francesco, additional, Sangiovanni, Vincenzo, additional, Sanrocco, Carlo, additional, Schiano Moriello, Nicola, additional, Scorzolini, Laura, additional, Sgariglia, Raffaella, additional, Simeone, Paola Giustina, additional, Spinicci, Michele, additional, Tamburrini, Enrica, additional, Torti, Carlo, additional, Trecarichi, Enrico Maria, additional, Vettor, Roberto, additional, Vianello, Andrea, additional, Vinceti, Marco, additional, Virdis, Agostino, additional, De Caterina, Raffaele, additional, and Iacoviello, Licia, additional

Published
2021
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30. Heparin in COVID-19 Patients Is Associated with Reduced In-Hospital Mortality: The Multicenter Italian CORIST Study

Author

Di Castelnuovo, Augusto, primary, Costanzo, Simona, primary, Antinori, Andrea, additional, Berselli, Nausicaa, additional, Blandi, Lorenzo, additional, Bonaccio, Marialaura, additional, Cauda, Roberto, additional, Guaraldi, Giovanni, additional, Menicanti, Lorenzo, additional, Mennuni, Marco, additional, Parruti, Giustino, additional, Patti, Giuseppe, additional, Santilli, Francesca, additional, Signorelli, Carlo, additional, Vergori, Alessandra, additional, Abete, Pasquale, additional, Ageno, Walter, additional, Agodi, Antonella, additional, Agostoni, Piergiuseppe, additional, Aiello, Luca, additional, Al Moghazi, Samir, additional, Arboretti, Rosa, additional, Astuto, Marinella, additional, Aucella, Filippo, additional, Barbieri, Greta, additional, Bartoloni, Alessandro, additional, Bonfanti, Paolo, additional, Cacciatore, Francesco, additional, Caiano, Lucia, additional, Carrozzi, Laura, additional, Cascio, Antonio, additional, Ciccullo, Arturo, additional, Cingolani, Antonella, additional, Cipollone, Francesco, additional, Colomba, Claudia, additional, Colombo, Crizia, additional, Crosta, Francesca, additional, Danzi, Gian Battista, additional, D'Ardes, Damiano, additional, de Gaetano Donati, Katleen, additional, Di Gennaro, Francesco, additional, Di Tano, Giuseppe, additional, D'Offizi, Gianpiero, additional, Fantoni, Massimo, additional, Fusco, Francesco Maria, additional, Gentile, Ivan, additional, Gianfagna, Francesco, additional, Grandone, Elvira, additional, Graziani, Emauele, additional, Grisafi, Leonardo, additional, Guarnieri, Gabriella, additional, Larizza, Giovanni, additional, Leone, Armando, additional, Maccagni, Gloria, additional, Madaro, Ferruccio, additional, Maitan, Stefano, additional, Mancarella, Sandro, additional, Mapelli, Massimo, additional, Maragna, Riccardo, additional, Marcucci, Rossella, additional, Maresca, Giulio, additional, Marongiu, Silvia, additional, Marotta, Claudia, additional, Marra, Lorenzo, additional, Mastroianni, Franco, additional, Mazzitelli, Maria, additional, Mengozzi, Alessandro, additional, Menichetti, Francesco, additional, Meschiari, Marianna, additional, Milic, Jovana, additional, Minutolo, Filippo, additional, Molena, Beatrice, additional, Montineri, Arturo, additional, Mussini, Cristina, additional, Musso, Maria, additional, Niola, Daniela, additional, Odone, Anna, additional, Olivieri, Marco, additional, Palimodde, Antonella, additional, Parisi, Roberta, additional, Pasi, Emanuela, additional, Pesavento, Raffaele, additional, Petri, Francesco, additional, Pinchera, Biagio, additional, Poletti, Venerino, additional, Ravaglia, Claudia, additional, Rognoni, Andrea, additional, Rossato, Marco, additional, Rossi, Marianna, additional, Sangiovanni, Vincenzo, additional, Sanrocco, Carlo, additional, Scorzolini, Laura, additional, Sgariglia, Raffaella, additional, Simeone, Paola Giustina, additional, Taddei, Eleonora, additional, Torti, Carlo, additional, Vettor, Roberto, additional, Vianello, Andrea, additional, Vinceti, Marco, additional, Virano, Alexandra, additional, Vocciante, Laura, additional, De Caterina, Raffaele, additional, and Iacoviello, Licia, additional

Published
2021
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31. COVID-19 infections among Healthcare Workers in an Infectious Diseases specialized setting in Naples, Southern Italy: results of a cross-sectional surveillance study

Author

Fusco, Francesco Maria, Pisaturo, Mariantonietta, Iodice, Valentina, Bellopede, Raffaele, Tambaro, Orsola, Parrella, Giovanni, Di Flumeri, Giusy, Viglietti, Rosaria, Pisapia, Raffaella, Carleo, Maria Aurora, Boccardi, Martina, Atripaldi, Luigi, Chignoli, Bruno, Maturo, Nicola, Rescigno, Carolina, Esposito, Vincenzo, Dell’Aversano, Raffaele, Sangiovanni, Vincenzo, and Punzi, Rodolfo

Subjects
Adult, Male, Emergency Medical Services, Infectious Disease Transmission, Patient-to-Professional, health care facilities, manpower, and services, Health Personnel, education, Pneumonia, Viral, SARS.CoV-2, Article, Betacoronavirus, Prevalence, Humans, Pandemics, Infection Control, Surveillance, SARS-CoV-2, Healthcare Workers, virus diseases, COVID-19, Middle Aged, Cross-Sectional Studies, Italy, Population Surveillance, Female, Coronavirus Infections
Abstract

A coronavirus disease 2019 (COVID-19) surveillance study was performed in March-April 2020 among asymptomatic healthcare workers (HCWs) at a specialist infectious diseases hospital in Naples, Italy. All HCWs underwent two rounds of molecular and serological testing for severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). One hundred and fifteen HCWs were tested; of these, two cases of infection were identified by reverse transcriptase polymerase chain reaction and two HCWs were SARS-CoV-2 immunoglobulin G seropositive. The overall prevalence of current or probable previous infection was 3.4%. The infection rate among HCWs was reasonably low. Most of the infected HCWs had been asymptomatic for the preceding 30 days, which supports the need for periodic screening of HCWs for COVID-19.

Published
2020

34. Highly infectious diseases in the Mediterranean Sea area: Inventory of isolation capabilities and recommendations for appropriate isolation

Author

Fusco, Francesco Maria, Brouqui, Philippe, Ippolito, Giuseppe, Vetter, G., Kojouharova, M., Parmakova, K., Skinhoej, P., Siikamaki, H., Perronne, C., Schilling, S., Gottschalk, R., Brodt, H. R., Maltezou, H. C., Adrami, O., Lambert, J., Puro, V., De Iaco, G., Hemmer, R., Borg, Michael Angelo, Fjellet, A. L., Brantsæter, A. B., Horban, A., Strle, F., Trilla, A., Bannister, B., Carson, G., EuroNHID Working Group, National Institute for Infectious Diseases, Microbes évolution phylogénie et infections (MEPHI), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Service des Maladies Infectieuses et Tropicales [CHU Raymond Poincaré], Hôpital Raymond Poincaré [AP-HP], ANR-10-IAHU-0003,Méditerranée Infection,I.H.U. Méditerranée Infection(2010), and EuroNHID Working Group

Subjects
Paper, Isolation (health care), Middle East respiratory syndrome coronavirus, 0211 other engineering and technologies, 02 engineering and technology, Communicable diseases, medicine.disease_cause, Microbiology, Communicable diseases -- Transmission -- Mediterranean Region, Mediterrània (Regió), lcsh:Infectious and parasitic diseases, 03 medical and health sciences, Globalization, 0302 clinical medicine, Mediterranean sea, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Epidemics -- Prevention, Mediterranean Sea, medicine, Epidèmies, highly infectious diseases, Social conflict, lcsh:RC109-216, 030212 general & internal medicine, Communicable diseases -- Mediterranean Region -- Prevention, Socioeconomics, Epidemics, 021110 strategic, defence & security studies, Public health, outbreak, Mediterranean Region, Isolation (Hospital care) -- Mediterranean Region, Outbreak, Nosocomial infections -- Prevention, Malalties infeccioses, [SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology, Salut pública, preparedness, 3. Good health, Infectious Diseases, Geography, Preparedness, isolation capabilities
Abstract

Epidemics such as viral haemorrhagic fevers, severe acute respiratory syndrome, Middle East respiratory syndrome coronavirus or yet unknown ones have few chances of disappearing. Globalization, worldwide travel, climate change, social conflicts and wars, among others, are likely to favor the emergence of epidemics. Preparedness of hospitals to prevent the spread of these outbreaks is among the prioritized political programmes of many countries. The EuroNHID network has in the past drawn a map of features and equipment of hospitals across Europe to take care of highly contagious patients. We update the data regarding isolation capabilities and recommendations, with an emphasis on Mediterranean countries., peer-reviewed

Published
2018

35. Burden of Disease in PWH Harboring a Multidrug-Resistant Virus: Data From the PRESTIGIO Registry.

Author

Galli, Laura, Parisi, Maria Rita, Poli, Andrea, Menozzi, Marianna, Fiscon, Marta, Garlassi, Elisa, Francisci, Daniela, Biagio, Antonio Di, Sterrantino, Gaetana, Fornabaio, Chiara, Antoni, Anna Degli, Angarano, Gioacchino, Fusco, Francesco Maria, Monforte, Antonella D'Arminio, Corbelli, Giulio Maria, Santoro, Maria Mercedes, Zazzi, Maurizio, Castagna, Antonella, and Group, PRESTIGIO Study

Subjects
MULTIDRUG-resistant tuberculosis, NON-nucleoside reverse transcriptase inhibitors, NUCLEOSIDE reverse transcriptase inhibitors, DISEASE incidence
Abstract

Background Currently, no data are available on the burden of morbidity and mortality in people with HIV-1 (PWH) harboring a 4-class drug-resistant (4DR) virus (nucleoside reverse transcriptase inhibitors, non-nucleoside reverse transcriptase inhibitors, protease inhibitors, integrase strand transfer inhibitors). The study aimed to assess the incidence of clinical events and death in this population. Methods This was a cohort study on PWH from the PRESTIGIO Registry with a documented 4DR virus. Burden of disease was defined as the occurrence of any new event including an AIDS-defining event (ADE) or non-AIDS-defining event (NADE) or death from any cause after 4DR evidence (baseline). Cox regression models evaluated factors associated with the risk of new clinical events/death. Results Among 148 PWH followed for a median (interquartile range) of 47 (32–84) months after 4DR evidence, 38 PWH had 62 new events or died from any cause (incidence rate, 9.12/100 person-years of follow-up; 95% CI = 6.85–11.39): 12 deaths (6 AIDS-related and 6 non-AIDS-related), 18 ADEs, 32 NADEs; 20 of the 38 NADEs (45%) of the incident clinical events were malignancies. The 4-year cumulative incidence of death was 6% (95% CI, 3%–13%), and that of ≥1 event or death was 22% (95% CI, 16%–31%). A higher risk of new clinical events/death was more likely in PWH with previous clinical events (adjusted hazard ratio [aHR], 2.67; 95% CI, 1.07–6.67) and marginally associated with lower baseline CD4+/CD8+ ratio (aHR, 0.82; 95% CI, 0.65–1.02). Conclusions PWH harboring 4DR have a high burden of disease with a worrying incidence of malignancies, strongly advising for close prevention and monitoring interventions as well as access to innovative therapeutic strategies, especially in people with a history of clinical events and low CD4+/CD8+ ratio. [ABSTRACT FROM AUTHOR]

Published
2020
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36. COVID-19 among healthcare workers in a specialist infectious diseases setting in Naples, Southern Italy: results of a cross-sectional surveillance study.

Author

Fusco, F.M., Pisaturo, M., Iodice, V., Bellopede, R., Tambaro, O., Parrella, G., Di Flumeri, G., Viglietti, R., Pisapia, R., Carleo, M.A., Boccardi, M., Atripaldi, L., Chignoli, B., Maturo, N., Rescigno, C., Esposito, V., Dell'Aversano, R., Sangiovanni, V., Punzi, R., and Fusco, Francesco Maria

Abstract

A coronavirus disease 2019 (COVID-19) surveillance study was performed in March-April 2020 among asymptomatic healthcare workers (HCWs) at a specialist infectious diseases hospital in Naples, Italy. All HCWs underwent two rounds of molecular and serological testing for severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). One hundred and fifteen HCWs were tested; of these, two cases of infection were identified by reverse transcriptase polymerase chain reaction and two HCWs were SARS-CoV-2 immunoglobulin G seropositive. The overall prevalence of current or probable previous infection was 3.4%. The infection rate among HCWs was reasonably low. Most of the infected HCWs had been asymptomatic for the preceding 30 days, which supports the need for periodic screening of HCWs for COVID-19. [ABSTRACT FROM AUTHOR]

Published
2020
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39. Non-randomised Ebola trials-lessons for optimal outbreak research

Author

Bates, Matthew, Zumla, Alimuddin, Ippolito, Giuseppe, Lanini, Simone, Brouqui, Philippe, Di Caro, Antonino, Vairo, Francesco, Fusco, Francesco Maria, Krishna, Sanjeev, Capobianchi, Maria Rosaria, Kyobe-Bosa, Henry, Puro, Vincenzo, Woelfel, Roman, Avsic-Zupanc, Tatjana, Ioannidis, John P. A., Portella, Gina, Kremsner, Peter, Dar, Osman, University College of London [London] (UCL), Department for Infectious Diseases, National Institute for Infectious Diseases ‘‘Lazarro Spallanzani’’, Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergentes (URMITE), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR48, INSB-INSB-Centre National de la Recherche Scientifique (CNRS), Hôpital Nord [CHU - APHM], Laboratory of microbiology and biorepository, INMI L. Spallanzani, Clinical Department, Institute for Infection and Immunity [Londres, UK], St George's, University of London, Laboratory of virology, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Biomedical Research Institute, Foundation for Research and Technology, Department of Medicine, Tufts University School of Medicine, Center for Genetic Epidemiology and Modeling and Tufts CTSI, Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Stanford Prevention Research Center, Stanford Medicine, Stanford University-Stanford University, Institut des sciences biologiques (INSB-CNRS)-Institut des sciences biologiques (INSB-CNRS)-Centre National de la Recherche Scientifique (CNRS), and University of Ioannina

Subjects
[SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, ComputingMilieux_MISCELLANEOUS
Abstract

International audience; no abstract

Published
2016

41. Clinical presentation and outcome of twenty cases of Invasive Meningococcal Disease due to Serogroup C – Clonal complex 11 in the Florence province, Italy, 2015–2016

Author

Fusco, Francesco Maria, primary, Baragli, Filippo, additional, Del Pin, Barbara, additional, Spina, Rosario, additional, Calamai, Italo, additional, Pecile, Patrizia, additional, Riccobono, Eleonora, additional, Nieddu, Francesco, additional, Moriondo, Maria, additional, Miglietta, Alessandro, additional, Voller, Fabio, additional, Fazio, Cecilia, additional, Stefanelli, Paola, additional, and Di Pietro, Massimo, additional

Published
2017
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42. Three cases of Zika virus imported in Italy: need for a clinical awareness and evidence-based knowledge

Author

Nicastri, Emanuele, primary, Pisapia, Raffaella, additional, Corpolongo, Angela, additional, Fusco, Francesco Maria, additional, Cicalini, Stefania, additional, Scognamiglio, Paola, additional, Castilletti, Concetta, additional, Bordi, Licia, additional, Di Caro, Antonino, additional, Capobianchi, Maria Rosaria, additional, Puro, Vincenzo, additional, and Ippolito, Giuseppe, additional

Published
2016
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43. Non-randomised Ebola trials—lessons for optimal outbreak research

Author

Ippolito, Giuseppe, primary, Lanini, Simone, additional, Brouqui, Philippe, additional, Di Caro, Antonino, additional, Vairo, Francesco, additional, Fusco, Francesco Maria, additional, Krishna, Sanjeev, additional, Capobianchi, Maria Rosaria, additional, Kyobe-Bosa, Henry, additional, Puro, Vincenzo, additional, Wölfel, Roman, additional, Avsic-Zupanc, Tatjana, additional, Ioannidis, John P A, additional, Portella, Gina, additional, Kremsner, Peter, additional, Dar, Osman, additional, Bates, Matthew, additional, and Zumla, Alimuddin, additional

Published
2016
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44. Ebola: missed opportunities for Europe–Africa research

Author

Ippolito, Giuseppe, primary, Lanini, Simone, additional, Brouqui, Philippe, additional, Di Caro, Antonino, additional, Vairo, Francesco, additional, Abdulla, Salim, additional, Fusco, Francesco Maria, additional, Krishna, Sanjeev, additional, Capobianchi, Maria Rosaria, additional, Kyobe-Bosa, Henry, additional, Lewis, David J M, additional, Puro, Vincenzo, additional, Wolfel, Roman, additional, Avsic-Zupanc, Tatjana, additional, Dar, Osman, additional, Mwaba, Peter, additional, Bates, Matthew, additional, Heymann, David, additional, and Zumla, Alimuddin, additional

Published
2015
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45. Reasons for switching ART: Comparison of data collected in 2012-2013 and 2014-2015 in Florence, Italy.

Author

Fusco, Francesco Maria, Burla, Maria Chiara, Esposti, Anna Degli, Pierotti, Piera, Rabatti, Loredana, and Vichi, Francesca

Subjects
THERAPEUTICS, HIV infections, ANTIRETROVIRAL agents, DRUG tolerance, COMORBIDITY, RETROSPECTIVE studies
Abstract

Persons living with HIV should remain on antiretroviral therapy (ART) indefinitely; however, a switch in the drug regimen is often necessary. In order to investigate if reasons for switching ART changed over time, we retrospectively analyzed reasons for switching and characteristics of switches among patients at Santa Maria Annunziata Hospital (OSMA), Florence area, Tuscany, Italy, over two periods (November 2012-October 2013 and November 2014-October 2015). The reasons for switching were classified as: simplification; virologic failure; occurrence of co-morbidities; and drug tolerability/toxicity issues. In period 1 (2012-2013), 18% patients changed their regimen vs. 13.5% in period 2 (2014-2015) (p = 0.019). Among reasons for switching, switches for simplification significantly increased from 41% in period 1 to 53% in period 2 (p = 0.004), with an increasing use of single tablet regimens (p = 0.002); no other statistically significant differences were found in other reasons for switching in periods 1 and 2. Characteristics of patients and of switches were analyzed and described. According to our data, the main reason for switching is now simplification, reflecting the recent changes in recommendations aimed to enhance adherence and quality of life, and to minimize, at the same time, drug toxicity and side effects. [ABSTRACT FROM AUTHOR]

Published
2018
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46. The added value of long-lasting preparedness for the management of a patient with Ebola

Author

Di Caro, Antonino, primary, Puro, Vincenzo, additional, Fusco, Francesco Maria, additional, Capobianchi, Maria Rosaria, additional, Lanini, Simone, additional, Lauria, Francesco Nicola, additional, Meschi, Silvia, additional, Nisii, Carla, additional, Petrosillo, Nicola, additional, Nicastri, Emanuele, additional, Pittalis, Silvia, additional, Travaglini, Damiano, additional, Vairo, Francesco, additional, and Ippolito, Giuseppe, additional

Published
2015
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47. Diagnostic issues and capabilities in 48 isolation facilities in 16 European countries: data from EuroNHID surveys

Author

Thiberville, Simon-Djamel, primary, Schilling, Stefan, additional, De Iaco, Giuseppina, additional, Fusco, Francesco Maria, additional, Thomson, Gail, additional, Maltezou, Helen C, additional, Gottschalk, Rene, additional, Brodt, Reinhard H, additional, Bannister, Barbara, additional, Puro, Vincenzo, additional, Ippolito, Giuseppe, additional, and Brouqui, Philippe, additional

Published
2012
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48. Influenza A (H1N1) in Rome, Italy in family: three case reports

Author

Lisena, Francesco, primary, Bordi, Licia, additional, Carletti, Fabrizio, additional, Castilletti, Concetta, additional, Ferraro, Federica, additional, Lalle, Eleonora, additional, Lanini, Simone, additional, Ruscitti, Luca Enrico, additional, and Fusco, Francesco Maria, additional

Published
2009
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50. Isolation Facilities for Highly Infectious Diseases in Europe – A Cross-Sectional Analysis in 16 Countries.

Author

Schilling, Stefan, Fusco, Francesco Maria, De Iaco, Giuseppina, Bannister, Barbara, Maltezou, Helena C., Carson, Gail, Gottschalk, Rene, Brodt, Hans-Reinhard, Brouqui, Philippe, Puro, Vincenzo, and Ippolito, Giuseppe

Subjects
*PREVENTION of infectious disease transmission, *WORLD health, *STANDARDIZATION
Abstract

Background: Highly Infectious Diseases (HIDs) are (i) easily transmissible form person to person; (ii) cause a life-threatening illness with no or few treatment options; and (iii) pose a threat for both personnel and the public. Hence, even suspected HID cases should be managed in specialised facilities minimizing infection risks but allowing state-of-the-art critical care. Consensus statements on the operational management of isolation facilities have been published recently. The study presented was set up to compare the operational management, resources, and technical equipment among European isolation facilities. Due to differences in geography, population density, and national response plans it was hypothesized that adherence to recommendations will vary. Methods and Findings: Until mid of 2010 the European Network for Highly Infectious Diseases conducted a cross-sectional analysis of isolation facilities in Europe, recruiting 48 isolation facilities in 16 countries. Three checklists were disseminated, assessing 44 items and 148 specific questions. The median feedback rate for specific questions was 97.9% (n = 47/48) (range: n = 7/48 (14.6%) to n = 48/48 (100%). Although all facilities enrolled were nominated specialised facilities' serving countries or regions, their design, equipment and personnel management varied. Eighteen facilities fulfilled the definition of a High Level Isolation Unit'. In contrast, 24 facilities could not operate independently from their co-located hospital, and five could not ensure access to equipment essential for infection control. Data presented are not representative for the EU in general, as only 16/27 (59.3%) of all Member States agreed to participate. Another limitation of this study is the time elapsed between data collection and publication; e.g. in Germany one additional facility opened in the meantime. Conclusion: There are disparities both within and between European countries regarding the design and equipment of isolation facilities. With regard to the International Health Regulations, terminology, capacities and equipment should be standardised. [ABSTRACT FROM AUTHOR]

Published
2014
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