Search

Your search keyword '"Fusco, Domenico"' showing total 286 results
Start Over Author "Fusco, Domenico"
286 results on '"Fusco, Domenico"'

12. Frailty modifies the effect of polypharmacy and multimorbidity on the risk of death among nursing home residents: Results from the SHELTER study

Author

Zazzara, Maria Beatrice, Villani, Emanuele Rocco, Palmer, Katie, Fialova, Daniela, Corsonello, Andrea, Soraci, Luca, Fusco, Domenico, Cipriani, Maria Camilla, Denkinger, Michael, Onder, Graziano, Liperoti, Rosa, Onder, Graziano (ORCID:0000-0003-3400-4491), Liperoti, Rosa (ORCID:0000-0003-3740-1687), Zazzara, Maria Beatrice, Villani, Emanuele Rocco, Palmer, Katie, Fialova, Daniela, Corsonello, Andrea, Soraci, Luca, Fusco, Domenico, Cipriani, Maria Camilla, Denkinger, Michael, Onder, Graziano, Liperoti, Rosa, Onder, Graziano (ORCID:0000-0003-3400-4491), and Liperoti, Rosa (ORCID:0000-0003-3740-1687)

Abstract

BackgroundFrailty, disability, and polypharmacy are prevalent in nursing home (NH) residents, often co-occurring with multimorbidity. There may be a complex interplay among them in terms of outcomes such as mortality. Aims of the study were to (i) assess whether nursing home residents with polypharmacy (5-9 medications) or hyperpolypharmacy (>= 10 drugs), have an increased risk of death and (ii) whether any association is modified by the co-presence of frailty or disability. MethodsCohort study with longitudinal mortality data including 4,023 residents from 50 European and 7 Israeli NH facilities (mean age = 83.6 years, 73.2% female) in The Services and Health for Elderly in Long Term care (SHELTER) cohort study. Participants were evaluated with the interRAI-LongTerm Care assessment tool. Frailty was evaluated with the FRAIL-NH scale. Hazard ratio (HR) of death over 12 months was assessed with stratified Cox proportional hazards models adjusted for demographics, facilities, and cognitive status. Results1,042 (25.9%) participants were not on polypharmacy, 49.8% (n = 2,002) were on polypharmacy, and 24.3% (n = 979) on hyperpolypharmacy. Frailty and disability mostly increased risk of death in the study population (frailty: HR = 1.85, 95%CI 1.49-2.28; disability: HR = 2.10, 95%CI 1.86-2.47). Among non-frail participants, multimorbidity (HR = 1.34, 95%CI = 1.01-1.82) and hyperpolypharmacy (HR = 1.61, 95%CI = 1.09-2.40) were associated with higher risk of death. Among frail participants, no other factors were associated with mortality. Polypharmacy and multimorbidity were not associated with mortality after stratification for disability. ConclusionsFrailty and disability are the strongest predictors of death in NH residents. Multimorbidity and hyperpolypharmacy increase mortality only in people without frailty. These findings may be relevant to identify patients who could benefit from tailored deprescription.

Published
2023

14. Frailty modifies the effect of polypharmacy and multimorbidity on the risk of death among nursing home residents: Results from the SHELTER study

Author

Zazzara, Maria Beatrice, primary, Villani, Emanuele Rocco, additional, Palmer, Katie, additional, Fialova, Daniela, additional, Corsonello, Andrea, additional, Soraci, Luca, additional, Fusco, Domenico, additional, Cipriani, Maria Camilla, additional, Denkinger, Michael, additional, Onder, Graziano, additional, and Liperoti, Rosa, additional

Published
2023
Full Text
View/download PDF

15. The Geriatrician: The Frontline Specialist in the Treatment of COVID-19 Patients

Author

Landi, Francesco, Barillaro, Christian, Bellieni, Andrea, Brandi, Vincenzo, Carfi, Angelo, Cipriani, Maria Camilla, D'Angelo, Emanuela, Falsiroli, Cinzia, Fusco, Domenico, Landi, Giovanni, Liperoti, Rosa, Lo Monaco, Maria Rita, Martone, Anna Maria, Marzetti, Emanuele, Pagano, Francesco Cosimo, Pais, Cristina, Russo, Andrea, Salini, Sara, Tosasto, Matteo, Tummolo, Anna Maria, Benvenuto, Francesca, Bramato, Giulia, Catalano, Lucia, Ciciarello, Francesca, Martis, Ilaria, Rocchi, Sara, Rota, Elisabetta, Salerno, Andrea, Tritto, Marcello, Sgadari, Antonio, Zuccàla, Giuseppe, and Bernabei, Roberto

Published
2020
Full Text
View/download PDF

19. Myelodysplasia

Author

Fusco, Domenico, primary, Bellieni, Andrea, additional, Di Capua, Beatrice, additional, and Colloca, Giuseppe, additional

Published
2022
Full Text
View/download PDF

20. Mirroring Emotions: Patients' Versus Caregivers' Perceptions of Sexual Experience in Parkinson's Disease

Author

Landi, Giovanni, primary, Monaco, Maria Rita Lo, additional, Stasio, Enrico Di, additional, Ricciardi, Diego, additional, Solito, Marcella, additional, Petracca, Martina, additional, Fusco, Domenico, additional, Rota, Elisabetta, additional, Salerno, Andrea, additional, Pagano, Francesco, additional, Liperoti, Rosa, additional, Bentivoglio, Anna Rita, additional, and Siveri, Maria Caterina, additional

Published
2021
Full Text
View/download PDF

24. Subacute onset dystonia in a woman affected by Parkinson's disease following SARS-COV-2 infection

Author

Lo Monaco, Maria Rita, Bentivoglio, Anna Rita, Fusco, Domenico, Calabresi, Paolo, Piano, Carla, Lo Monaco, Maria Rita (ORCID:0000-0002-1457-7981), Bentivoglio, Anna Rita (ORCID:0000-0002-9663-095X), Calabresi, Paolo (ORCID:0000-0003-0326-5509), Lo Monaco, Maria Rita, Bentivoglio, Anna Rita, Fusco, Domenico, Calabresi, Paolo, Piano, Carla, Lo Monaco, Maria Rita (ORCID:0000-0002-1457-7981), Bentivoglio, Anna Rita (ORCID:0000-0002-9663-095X), and Calabresi, Paolo (ORCID:0000-0003-0326-5509)

Abstract

N/A

Published
2021

25. Should face masks be worn to contain the spread of COVID-19 in the postlockdown phase?

Author

Landi, Francesco, Marzetti, Emanuele, Sanguinetti, Maurizio, Ciciarello, Francesca, Tritto, Marcello, Benvenuto, Francesca, Bramato, Giulia, Brandi, Vincenzo, Carfì, Angelo, D'Angelo, Emanuela, Fusco, Domenico, Lo Monaco, Maria Rita, Martone, Anna Maria, Pagano, Francesco Cosimo, Rocchi, Sara, Rota, Elisabetta, Russo, Andrea, Salerno, Andrea Maria, Cattani Franchi, Paola, Marchetti, Simona, Bernabei, Roberto, Landi, Francesco (ORCID:0000-0002-3472-1389), Marzetti, Emanuele (ORCID:0000-0001-9567-6983), Sanguinetti, Maurizio (ORCID:0000-0002-9780-7059), Lo Monaco, Maria Rita (ORCID:0000-0002-1457-7981), Pagano, Francesco, Salerno, Andrea, Cattani, Paola (ORCID:0000-0003-4678-4763), Bernabei On Behalf Of The Gemelli Against Covid-Geriatric Team, Roberto (ORCID:0000-0002-9197-004X), Landi, Francesco, Marzetti, Emanuele, Sanguinetti, Maurizio, Ciciarello, Francesca, Tritto, Marcello, Benvenuto, Francesca, Bramato, Giulia, Brandi, Vincenzo, Carfì, Angelo, D'Angelo, Emanuela, Fusco, Domenico, Lo Monaco, Maria Rita, Martone, Anna Maria, Pagano, Francesco Cosimo, Rocchi, Sara, Rota, Elisabetta, Russo, Andrea, Salerno, Andrea Maria, Cattani Franchi, Paola, Marchetti, Simona, Bernabei, Roberto, Landi, Francesco (ORCID:0000-0002-3472-1389), Marzetti, Emanuele (ORCID:0000-0001-9567-6983), Sanguinetti, Maurizio (ORCID:0000-0002-9780-7059), Lo Monaco, Maria Rita (ORCID:0000-0002-1457-7981), Pagano, Francesco, Salerno, Andrea, Cattani, Paola (ORCID:0000-0003-4678-4763), and Bernabei On Behalf Of The Gemelli Against Covid-Geriatric Team, Roberto (ORCID:0000-0002-9197-004X)

Abstract

Background: In East Asia, face masks are commonly worn to reduce viral spread. In Euope and North America, however, their use has been stigmatised for a long time, although this view has radically changed during the ongoing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic. Notwithstanding this, it is still unclear whether face masks worn by COVID-19 carriers may indeed prevent viral transmission and environmental contamination. The objective of this study was to evaluate the effectiveness of surgical face masks in filtering SARS-CoV-2.Methods: Four male patients with COVID-19 were recruited for the study. Two patients wore a surgical mask for 5 h, while two others did not. The spread of the virus in the environment was evaluated through the approved Allplex 2019-nCoV assay.Results: In the room with the two patients without surgical masks, the swab performed on the headboard and sides of the beds was positive for SARS-CoV-2 contamination. In the other room, where two patients were wearing surgical masks, all of the swabs obtained after 5 h tested negative.Conclusions: The results of the current study add to the growing body of literature supporting the use of face masks as a measure to contain the spread of SARS-CoV-2 by retaining potentially contagious droplets that can infect other people and/or contaminate surfaces. Based on the current evidence, face masks should therefore be considered a useful and low-cost device in addition to social distancing and hand hygiene during the postlockdown phase.

Published
2021

26. Different impact of definitions of sarcopenia in defining frailty status in a population of older women with early breast cancer

Author

Bellieni, Agnese, Fusco, Domenico, Sanchez, A. M., Franceschini, Gianluca, Di Capua, B., Allocca, E., Di Stasio, Enrico, Marazzi, Fabio, Tagliaferri, Luca, Masetti, Riccardo, Bernabei, Roberto, Colloca, Giuseppe Ferdinando, Bellieni A., Fusco D., Franceschini G. (ORCID:0000-0002-2950-3395), Di Stasio E. (ORCID:0000-0003-1047-4261), Marazzi F., Tagliaferri L. (ORCID:0000-0003-2308-0982), Masetti R. (ORCID:0000-0002-7520-9111), Bernabei R. (ORCID:0000-0002-9197-004X), Colloca G. F., Bellieni, Agnese, Fusco, Domenico, Sanchez, A. M., Franceschini, Gianluca, Di Capua, B., Allocca, E., Di Stasio, Enrico, Marazzi, Fabio, Tagliaferri, Luca, Masetti, Riccardo, Bernabei, Roberto, Colloca, Giuseppe Ferdinando, Bellieni A., Fusco D., Franceschini G. (ORCID:0000-0002-2950-3395), Di Stasio E. (ORCID:0000-0003-1047-4261), Marazzi F., Tagliaferri L. (ORCID:0000-0003-2308-0982), Masetti R. (ORCID:0000-0002-7520-9111), Bernabei R. (ORCID:0000-0002-9197-004X), and Colloca G. F.

Abstract

Sarcopenia is a geriatric syndrome characterized by losses of quantity and quality of skeletal muscle, which is associated with negative outcomes in older adults and in cancer patients. Different definitions of sarcopenia have been used, with quantitative data more frequently used in oncology, while functional measures have been advocated in the geriatric literature. Little is known about the correlation between frailty status as assessed by comprehensive geriatric assessment (CGA) and sarcopenia in cancer patients. We retrospectively analyzed data from 96 older women with early breast cancer who underwent CGAs and Dual X-ray Absorptiometry (DXA) scans for muscle mass assessment before cancer treatment at a single cancer center from 2016 to 2019 to explore the correlation between frailty status as assessed by CGA and sarcopenia using different definitions. Based on the results of the CGA, 35 patients (36.5%) were defined as frail. Using DXA Appendicular Skeletal Mass (ASM) or the Skeletal Muscle Index (SMI=ASM/heightˆ2), 41 patients were found to be sarcopenic (42.7%), with no significant difference in prevalence between frail and nonfrail subjects. Using the European Working Group on Sarcopenia in Older People (EWGSOP2) definition of sarcopenia (where both muscle function and mass are required), 58 patients were classified as “probably” sarcopenic; among these, 25 were sarcopenic and 17 “severely” sarcopenic. Only 13 patients satisfied both the requirements for being defined as sarcopenic and frail. Grade 3-4 treatment-related toxicities (according to Common Terminology Criteria for Adverse Events) were more common in sarcopenic and frail sarcopenic patients. Our data support the use of a definition of sarcopenia that includes both quantitative and functional data in order to identify frail patients who need tailored treatment.

Published
2021

27. Gender may be related to the side of the motor syndrome and cognition in idiopathic Parkinson's disease

Author

Bentivoglio, Anna Rita, Lo Monaco, Maria Rita, Liperoti, Rosa, Fusco, Domenico, Di Stasio, Enrico, Tondinelli, A., Marzullo, D., Maino, Alessandro, Cipriani, Maria Camilla, Silveri, Maria Caterina, Bentivoglio A. R. (ORCID:0000-0002-9663-095X), Lo Monaco M. R. (ORCID:0000-0002-1457-7981), Liperoti R. (ORCID:0000-0003-3740-1687), Fusco D., Di Stasio E. (ORCID:0000-0003-1047-4261), Maino A., Cipriani M. C., Silveri M. C. (ORCID:0000-0001-5012-0682), Bentivoglio, Anna Rita, Lo Monaco, Maria Rita, Liperoti, Rosa, Fusco, Domenico, Di Stasio, Enrico, Tondinelli, A., Marzullo, D., Maino, Alessandro, Cipriani, Maria Camilla, Silveri, Maria Caterina, Bentivoglio A. R. (ORCID:0000-0002-9663-095X), Lo Monaco M. R. (ORCID:0000-0002-1457-7981), Liperoti R. (ORCID:0000-0003-3740-1687), Fusco D., Di Stasio E. (ORCID:0000-0003-1047-4261), Maino A., Cipriani M. C., and Silveri M. C. (ORCID:0000-0001-5012-0682)

Abstract

Background: and Sex and cognitive profile may be related to the laterality of motor symptoms in idiopathic Parkinson's disease. Introduction: Parkinson's disease (PD) is well recognised as an inherently asymmetric disease with unilateral onset of motor symptoms. The laterality of motor symptoms may be linked to sex, clinical and demographic variables, and neuropsychological disorders. However, the available data are inconsistent. This study aimed to explore the potential association between the laterality of motor symptoms and clinical and demographic variables and deficits in specific cognitive domains. Material and methods: We retrospectively recruited 97 participants with idiopathic PD without dementia; 60 presented motor symptoms on the left side and 37 on the right side. Both groups were comparable in terms of age, age at disease onset, disease duration, and severity of the neurological deficits according to the Unified Parkinson's Disease Rating Scale and the Hoehn and Yahr scale. Results: Participants with left-side motor symptoms scored lower on the Schwab and England Activities of Daily Living scale. Our sample included more men than women (67% vs. 33%). Both sexes were not equally represented in the 2 groups: there were significantly more men than women in the group of patients with left-side motor symptoms (77% vs. 23%), whereas the percentages of men and women in the group of patients with right-side motor symptoms were similar (51% vs. 49%). Both groups performed similarly in all neuropsychological tasks, but women, independently of laterality, performed better than men in the naming task. Conclusion: We found a clear prevalence of men in the group of patients with left-side motor symptoms; this group also scored lower on the Schwab and England Scale. Female sex was predictive of better performance in the naming task. Sex should always be considered in disorders that cause asymmetric involvement of the brain, such as PD.

Published
2021

28. Perspectives and limits of cancer treatment in an oldest old population

Author

Di Capua, B., Bellieni, A., Fusco, Domenico, Gambacorta, Maria Antonietta, Tagliaferri, Luca, Villani, Emanuele Rocco, Bernabei, Roberto, Valentini, Vincenzo, Colloca, Giuseppe Ferdinando, Fusco D., Gambacorta M. A. (ORCID:0000-0001-5455-8737), Tagliaferri L. (ORCID:0000-0003-2308-0982), Villani E. R., Bernabei R. (ORCID:0000-0002-9197-004X), Valentini V. (ORCID:0000-0003-4637-6487), Colloca G. F., Di Capua, B., Bellieni, A., Fusco, Domenico, Gambacorta, Maria Antonietta, Tagliaferri, Luca, Villani, Emanuele Rocco, Bernabei, Roberto, Valentini, Vincenzo, Colloca, Giuseppe Ferdinando, Fusco D., Gambacorta M. A. (ORCID:0000-0001-5455-8737), Tagliaferri L. (ORCID:0000-0003-2308-0982), Villani E. R., Bernabei R. (ORCID:0000-0002-9197-004X), Valentini V. (ORCID:0000-0003-4637-6487), and Colloca G. F.

Abstract

Background: Population of oldest old will grow dramatically in the next future and cancer, physiologically related to aging, will be very prevalent among them. Lack of evidence is a huge problem to manage cancer in oldest old and will be more and more in the next years. Aims: Our purpose was to investigate the characteristics of a population of oldest old patients with cancer treated in the Radiation Oncology Unit of Fondazione Policlinico A. Gemelli IRCCS. Methods: We conducted a retrospective study. The primary outcome was to evaluate which characteristics of the population could influence the choice of oncological treatment (with radical or non-radical intent). Results: We identified a total of 348 patients: 140 were on follow-up; 177 were under treatment; 31 were considered not eligible for treatments. Patients under treatment had a high comorbidity index (mean Charlson Comorbidity Index 5.4), and a high prevalence of polypharmacy (mean number of drugs 5.6). More than half (53.1%) was treated with radical intent. Patients treated with radical intent were 1 year younger (87.1 years old vs 88.1 years old), more performant (ECOG 0.7 vs 1.3), and had less prevalence of metastatic neoplasia (6.4% vs 34.9%); comorbidities and drugs did not show differences in the two groups. Conclusion: Oldest old, usually not considered in international guidelines, are treated for oncological disease, often with radical intent. The treatment seems not to be tailored considering comorbidities but on performance status.

Published
2021

29. Different Impact of Definitions of Sarcopenia in Defining Frailty Status in a Population of Older Women with Early Breast Cancer. J Pers Med. 11(4):243. PMID: 33810556

Author

Biellini, A, Fusco, Domenico, Sanchez, Am, Franceschini, Gianluca, Di Capua, B, Allocca, E, Di Stasio, Enrico, Marazzi, Fabio, Tagliaferri, Luca, Masetti, Riccardo, Bernabei, Roberto, Colloca, Giuseppe Ferdinando, Fusco D, Franceschini G (ORCID:0000-0002-2950-3395), Di Stasio E (ORCID:0000-0003-1047-4261), Marazzi F, Tagliaferri L (ORCID:0000-0003-2308-0982), Masetti R (ORCID:0000-0002-7520-9111), Bernabei R (ORCID:0000-0002-9197-004X), Colloca GF., Biellini, A, Fusco, Domenico, Sanchez, Am, Franceschini, Gianluca, Di Capua, B, Allocca, E, Di Stasio, Enrico, Marazzi, Fabio, Tagliaferri, Luca, Masetti, Riccardo, Bernabei, Roberto, Colloca, Giuseppe Ferdinando, Fusco D, Franceschini G (ORCID:0000-0002-2950-3395), Di Stasio E (ORCID:0000-0003-1047-4261), Marazzi F, Tagliaferri L (ORCID:0000-0003-2308-0982), Masetti R (ORCID:0000-0002-7520-9111), Bernabei R (ORCID:0000-0002-9197-004X), and Colloca GF.

Abstract

Sarcopenia is a geriatric syndrome characterized by losses of quantity and quality of skeletal muscle, which is associated with negative outcomes in older adults and in cancer patients. Different definitions of sarcopenia have been used, with quantitative data more frequently used in oncology, while functional measures have been advocated in the geriatric literature. Little is known about the correlation between frailty status as assessed by comprehensive geriatric assessment (CGA) and sarcopenia in cancer patients. We retrospectively analyzed data from 96 older women with early breast cancer who underwent CGAs and Dual X-ray Absorptiometry (DXA) scans for muscle mass assessment before cancer treatment at a single cancer center from 2016 to 2019 to explore the correlation between frailty status as assessed by CGA and sarcopenia using different definitions. Based on the results of the CGA, 35 patients (36.5%) were defined as frail. Using DXA Appendicular Skeletal Mass (ASM) or the Skeletal Muscle Index (SMI=ASM/heightˆ2), 41 patients were found to be sarcopenic (42.7%), with no significant difference in prevalence between frail and nonfrail subjects. Using the European Working Group on Sarcopenia in Older People (EWGSOP2) definition of sarcopenia (where both muscle function and mass are required), 58 patients were classified as “probably” sarcopenic; among these, 25 were sarcopenic and 17 “severely” sarcopenic. Only 13 patients satisfied both the requirements for being defined as sarcopenic and frail. Grade 3-4 treatment-related toxicities (according to Common Terminology Criteria for Adverse Events) were more common in sarcopenic and frail sarcopenic patients. Our data support the use of a definition of sarcopenia that includes both quantitative and functional data in order to identify frail patients who need tailored treatment.

Published
2021

30. Gender may be related to the side of the motorsyndrome and cognition in idiopathic Parkinson’sdisease

Author

Bentivoglio, Anna Rita, Lo Monaco, Maria Rita, Liperoti, Rosa, Fusco, Domenico, Di Stasio, Enrico, Tondinelli, A, Maino, A, Marzullo, D, Cipriani, Maria Camilla, Silveri, Maria Caterina, Bentivoglio AR (ORCID:0000-0002-9663-095X), Lo Monaco MR (ORCID:0000-0002-1457-7981), Liperoti R (ORCID:0000-0003-3740-1687), Fusco D, Di Stasio E (ORCID:0000-0003-1047-4261), Cipriani MC, Silveri MC (ORCID:0000-0001-5012-0682), Bentivoglio, Anna Rita, Lo Monaco, Maria Rita, Liperoti, Rosa, Fusco, Domenico, Di Stasio, Enrico, Tondinelli, A, Maino, A, Marzullo, D, Cipriani, Maria Camilla, Silveri, Maria Caterina, Bentivoglio AR (ORCID:0000-0002-9663-095X), Lo Monaco MR (ORCID:0000-0002-1457-7981), Liperoti R (ORCID:0000-0003-3740-1687), Fusco D, Di Stasio E (ORCID:0000-0003-1047-4261), Cipriani MC, and Silveri MC (ORCID:0000-0001-5012-0682)

Abstract

Parkinson's disease s a well recognised

Published
2021

32. COVID-19 and intestinal inflammation: Role of fecal calprotectin

Author

Abbate, Valeria, Acampora, Nicola, Addolorato, Giovanni, Agostini, Fabiana, Ainora, Maria Elena, Akacha, Karim, Amato, Elena, Andreani, Francesca, Andriollo, Gloria, Annetta, Maria Giuseppina, Annicchiarico, Brigida Eleonora, Antonelli, Mariangela, Antonucci, Gabriele, Anzellotti, Gian Marco, Armuzzi, Alessandro, Baldi, Fabiana, Barattucci, Ilaria, Barillaro, Christian, Barone, Fabiana, Bellantone, Rocco Domenico Alfonso, Bellieni, Andrea, Bello, Giuseppe, Benicchi, Andrea, Benvenuto, Francesca, Berardini, Ludovica, Berloco, Filippo, Bernabei, Roberto, Bianchi, Antonio, Biasucci, Daniele Guerino, Biasucci, Luigi Marzio, Bibbò, Stefano, Bini, Alessandra, Bisanti, Alessandra, Biscetti, Federico, Bocci, Maria Grazia, Bonadia, Nicola, Bongiovanni, Filippo, Borghetti, Alberto, Bosco, Giulia, Bosello, Silvia, Bove, Vincenzo, Bramato, Giulia, Brandi, Vincenzo, Bruni, Teresa, Bruno, Carmine, Bruno, Dario, Bungaro, Maria Chiara, Buonomo, Alessandro, Burzo, Livia, Calabrese, Angelo, Calvello, Maria Rosaria, Cambieri, Andrea, Cambise, Chiara, Cammà, Giulia, Candelli, Marcello, Canistro, Gennaro, Cantanale, Antonello, Capalbo, Gennaro, Capaldi, Lorenzo, Capone, Emanuele, Capristo, Esmeralda, Carbone, Luigi, Cardone, Silvia, Carelli, Simone, Carfì, Angelo, Carnicelli, Annamaria, Caruso, Cristiano, Casciaro, Francesco Antonio, Catalano, Lucio, Cauda, Roberto, Cecchini, Andrea Leonardo, Cerrito, Lucia, Cesarano, Melania, Chiarito, Annalisa, Cianci, Rossella, Cicchinelli, Sara, Ciccullo, Arturo, Cicetti, Marta, Ciciarello, Francesca, Cingolani, Antonella, Cipriani, Maria Camilla, Consalvo, Maria Ludovica, Coppola, Gaetano, Corbo, Giuseppe Maria, Corsello, Andrea, Costante, Federico, Costanzi, Matteo, Covino, Marcello, Crupi, Davide, Cutuli, Salvatore Lucio, D'Addio, Stefano, D'Alessandro, Alessia, D'AlfonsoD'Angelo, Maria ElenaEmanuela, D'Aversa, Francesca, Damiano, Fernando, De Berardinis, Gian Maria, De Cunzo, Tommaso, De Gaetano, Donati Katleen, De Luca, Giulio, De Matteis, Giuseppe, De Pascale, Gennaro, De Santis, Paolo, De Siena, Martina, De Vito, Francesco, Del Gatto, Valeria, Del Giacomo, Paola, Del Zompo, Fabio, Dell'Anna, Antonio Maria, Polla, Davide Della, Di Gialleonardo, Luca, Di Giambenedetto, Simona, Di Luca, Roberta, Di Maurizio, Luca, Di Muro, Mariangela, Dusina, Alex, Eleuteri, Davide, Esperide, Alessandra, Fachechi, Daniele, Faliero, Domenico, Falsiroli, Cinzia, Fantoni, Massimo, Fedele, Annalaura, Feliciani, Daniela, Ferrante, Cristina, Ferrone, Giuliano, Festa, Rossano, Fiore, Maria Chiara, Flex, Andrea, Forte, Evelina, Franceschi, Francesco, Francesconi, Alessandra, Franza, Laura, Funaro, Barbara, Fuorlo, Mariella, Fusco, Domenico, Gabrielli, Maurizio, Gaetani, Eleonora, Galletta, Claudia, Gallo, Antonella, Gambassi, Giovanni, Garcovich, Matteo, Gasbarrini, Antonio, Gasparrini, Irene, Gelli, Silvia, Giampietro, Antonella, Gigante, Laura, Giuliano, Gabriele, Giuliano, Giorgia, Giupponi, Bianca, Gremese, Elisa, Grieco, Domenico Luca, Guerrera, Manuel, Guglielmi, Valeria, Guidone, Caterina, Gullì, Antonio, Iaconelli, Amerigo, Iafrati, Aurora, Ianiro, Gianluca, Iaquinta, Angela, Impagnatiello, Michele, Inchingolo, Riccardo, Intini, Enrica, Iorio, Raffaele, Izzi, Immacolata Maria, Jovanovic, Tamara, Kadhim, Cristina, La Macchia, Rosa, La Milia, Daniele Ignazio, Landi, Francesco, Landi, Giovanni, Landi, Rosario, Landolfi, Raffaele, Leo, Massimo, Leone, Paolo Maria, Levantesi, Laura, Liguori, Antonio, Liperoti, Rosa, Lizzio, Marco Maria, Monaco, Maria Rita Lo, Locantore, Pietro, Lombardi, Francesco, Lombardi, Gianmarco, Lopetuso, Loris, Loria, Valentina, Losito, Angela Raffaella, Lucia, Mothanje Barbara Patricia, Macagno, Francesco, Macerola, Noemi, Maggi, Giampaolo, Maiuro, Giuseppe, Mancarella, Francesco, Mangiola, Francesca, Manno, Alberto, Marchesini, Debora, Maresca, Gian Marco, Marrone, Giuseppe, Martis, Ilaria, Martone, Anna Maria, Marzetti, Emanuele, Mattana, Chiara, Matteo, Maria Valeria, Maviglia, Riccardo, Mazzarella, Ada, Memoli, Carmen, Miele, Luca, Migneco, Alessio, Mignini, Irene, Milani, Alessandro, Milardi, Domenico, Montalto, Massimo, Montemurro, Giuliano, Monti, Flavia, Montini, Luca, Morena, Tony Christian, Morra, Vincenzina, Morretta, Chiara, Moschese, Davide, Murace, Celeste Ambra, Murdolo, Martina, Murri, Rita, Napoli, Marco, Nardella, Elisabetta, Natalello, Gerlando, Natalini, Daniele, Navarra, Simone Maria, Nesci, Antonio, Nicoletti, Alberto, Nicoletti, Rocco, Nicoletti, Tommaso Filippo, Nicolò, Rebecca, Nicolotti, Nicola, Nista, Enrico Celestino, Nuzzo, Eugenia, Oggiano, Marco, Ojetti, Veronica, Pagano, Francesco Cosimo, Paiano, Gianfranco, Pais, Cristina, Pallavicini, Federico, Palombo, Andrea, Paolillo, Federico, Papa, Alfredo, Papanice, Domenico, Papparella, Luigi Giovanni, Paratore, Mattia, Parrinello, Giuseppe, Pasciuto, Giuliana, Pasculli, Pierpaolo, Pecorini, Giovanni, Perniola, Simone, Pero, Erika, Petricca, Luca, Petrucci, Martina, Picarelli, Chiara, Piccioni, Andrea, Piccolo, Annalisa, Piervincenzi, Edoardo, Pignataro, Giulia, Pignataro, Raffaele, Pintaudi, Gabriele, Pisapia, Luca, Pizzoferrato, Marco, Pizzolante, Fabrizio, Pola, Roberto, Policola, Caterina, Pompili, Maurizio, Pontecorvi, Flavia, Pontecorvi, Valerio, Ponziani, Francesca, Popolla, Valentina, Porceddu, Enrica, Porfidia, Angelo, Porro, Lucia Maria, Potenza, Annalisa, Pozzana, Francesca, Privitera, Giuseppe, Pugliese, Daniela, Pulcini, Gabriele, Racco, Simona, Raffaelli, Francesca, Ramunno, Vittoria, Rapaccini, Gian Ludovico, Richeldi, Luca, Rinninella, Emanuele, Rocchi, Sara, Romanò, Bruno, Romano, Stefano, Rosa, Federico, Rossi, Laura, Rossi, Raimondo, Rossini, Enrica, Rota, Elisabetta, Rovedi, Fabiana, Rubino, Carlotta, Rumi, Gabriele, Russo, Andrea, Sabia, Luca, Salerno, Andrea, Salini, Sara, Salvatore, Lucia, Samori, Dehara, Sandroni, Claudio, Sanguinetti, Maurizio, Santarelli, Luca, Santini, Paolo, Santolamazza, Danilo, Santoliquido, Angelo, Santopaolo, Francesco, Santoro, Michele Cosimo, Sardeo, Francesco, Sarnari, Caterina, Saviano, Angela, Saviano, Luisa, Scaldaferri, Franco, Scarascia, Roberta, Schepis, Tommaso, Schiavello, Francesca, Scoppettuolo, Giancarlo, Sedda, Davide, Sessa, Flaminio, Sestito, Luisa, Settanni, Carlo, Siciliano, Matteo, Siciliano, Valentina, Sicuranza, Rossella, Simeoni, Benedetta, Simonetti, Jacopo, Smargiassi, Andrea, Soave, Paolo Maurizio, Sonnino, Chiara, Staiti, Domenico, Stella, Claudia, Stella, Leonardo, Stival, Eleonora, Taddei, Eleonora, Talerico, Rossella, Tamburello, Elio, Tamburrini, Enrica, Tanzarella, Eloisa Sofia, Tarascio, Elena, Tarli, Claudia, Tersali, Alessandra, Tilli, Pietro, Timpano, Jacopo, Torelli, Enrico, Torrini, Flavia, Tosato, Matteo, Tosoni, Alberto, Tricoli, Luca, Tritto, Marcello, Tumbarello, Mario, Tummolo, Anita Maria, Vallecoccia, Maria Sole, Valletta, Federico, Varone, Francesco, Vassalli, Francesco, Ventura, Giulio, Verardi, Lucrezia, Vetrone, Lorenzo, Vetrugno, Giuseppe, Visconti, Elena, Visconti, Felicia, Viviani, Andrea, Zaccaria, Raffaella, Zaccone, Carmelina, Zelano, Lorenzo, Dal Verme, Lorenzo Zileri, Zuccalà, Giuseppe, and Troiani, Eliana

Published
2020
Full Text
View/download PDF

34. Different Impact of Definitions of Sarcopenia in Defining Frailty Status in a Population of Older Women with Early Breast Cancer

Author

Bellieni, Andrea, primary, Fusco, Domenico, additional, Sanchez, Alejandro Martin, additional, Franceschini, Gianluca, additional, Di Capua, Beatrice, additional, Allocca, Elena, additional, Di Stasio, Enrico, additional, Marazzi, Fabio, additional, Tagliaferri, Luca, additional, Masetti, Riccardo, additional, Bernabei, Roberto, additional, and Colloca, Giuseppe Ferdinando, additional

Published
2021
Full Text
View/download PDF

38. Assessment of neurological manifestations in hospitalized patients with COVID-19

Author

Luigetti, M., Iorio, R., Bentivoglio, A. R., Tricoli, L., Riso, V., Marotta, J., Piano, C., Primiano, G., Zileri Del Verme, L., Lo Monaco, M. R., Calabresi, P., Abbate, Valeria, Acampora, Nicola, Addolorato, Giovanni, Agostini, Fabiana, Ainora, Maria Elena, Akacha, Karim, Amato, Elena, Andreani, Francesca, Andriollo, Gloria, Annetta, Maria Giuseppina, Annicchiarico, Brigida Eleonora, Antonelli, Mariangela, Antonucci, Gabriele, Anzellotti, Gian Marco, Armuzzi, Alessandro, Baldi, Fabiana, Barattucci, Ilaria, Barillaro, Christian, Barone, Fabiana, Bellantone, Rocco Domenico Alfonso, Bellieni, Andrea, Bello, Giuseppe, Benicchi, Andrea, Benvenuto, Francesca, Berardini, Ludovica, Berloco, Filippo, Bernabei, Roberto, Bianchi, Antonio, Biasucci, Daniele Guerino, Biasucci, Luigi Marzio, Bibbò, Stefano, Bini, Alessandra, Bisanti, Alessandra, Biscetti, Federico, Bocci, Maria Grazia, Bonadia, Nicola, Bongiovanni, Filippo, Borghetti, Alberto, Bosco, Giulia, Bosello, Silvia, Bove, Vincenzo, Bramato, Giulia, Brandi, Vincenzo, Bruni, Teresa, Bruno, Carmine, Bruno, Dario, Bungaro, Maria Chiara, Buonomo, Alessandro, Burzo, Livia, Calabrese, Angelo, Calvello, Maria Rosaria, Cambieri, Andrea, Cambise, Chiara, Cammà, Giulia, Candelli, Marcello, Canistro, Gennaro, Cantanale, Antonello, Capalbo, Gennaro, Capaldi, Lorenzo, Capone, Emanuele, Capristo, Esmeralda, Carbone, Luigi, Cardone, Silvia, Carelli, Simone, Carfì, Angelo, Carnicelli, Annamaria, Caruso, Cristiano, Casciaro, Francesco Antonio, Catalano, Lucio, Cauda, Roberto, Cecchini, Andrea Leonardo, Cerrito, Lucia, Cesarano, Melania, Chiarito, Annalisa, Cianci, Rossella, Cicchinelli, Sara, Ciccullo, Arturo, Cicetti, Marta, Ciciarello, Francesca, Cingolani, Antonella, Cipriani, Maria Camilla, Consalvo, Maria Ludovica, Coppola, Gaetano, Corbo, Giuseppe Maria, Corsello, Andrea, Costante, Federico, Costanzi, Matteo, Covino, Marcello, Crupi, Davide, Cutuli, Salvatore Lucio, DAddio, Stefano, DAlessandro, Alessia, DAlfonso, Maria Elena, DAngelo, Emanuela, DAversa, Francesca, Damiano, Fernando, De Berardinis, Gian Maria, De Cunzo, Tommaso, De Gaetano, Donati Katleen, De Luca, Giulio, De Matteis, Giuseppe, De Pascale, Gennaro, De Santis, Paolo, De Siena, Martina, De Vito, Francesco, Del Gatto, Valeria, Del Giacomo, Paola, Del Zompo, Fabio, DellAnna, Antonio Maria, Della, Polla Davide, Di Gialleonardo, Luca, Di Giambenedetto, Simona, Di Luca, Roberta, Di Maurizio, Luca, Di Muro, Mariangela, Dusina, Alex, Eleuteri, Davide, Esperide, Alessandra, Fachechi, Daniele, Faliero, Domenico, Falsiroli, Cinzia, Fantoni, Massimo, Fedele, Annalaura, Feliciani, Daniela, Ferrante, Cristina, Ferrone, Giuliano, Festa, Rossano, Fiore, Maria Chiara, Flex, Andrea, Forte, Evelina, Franceschi, Francesco, Francesconi, Alessandra, Franza, Laura, Funaro, Barbara, Fuorlo, Mariella, Fusco, Domenico, Gabrielli, Maurizio, Gaetani, Eleonora, Galletta, Claudia, Gallo, Antonella, Gambassi, Giovanni, Garcovich, Matteo, Gasbarrini, Antonio, Gasparrini, Irene, Gelli, Silvia, Giampietro, Antonella, Gigante, Laura, Giuliano, Gabriele, Giuliano, Giorgia, Giupponi, Bianca, Gremese, Elisa, Grieco, Domenico Luca, Guerrera, Manuel, Guglielmi, Valeria, Guidone, Caterina, Gullì, Antonio, Iaconelli, Amerigo, Iafrati, Aurora, Ianiro, Gianluca, Iaquinta, Angela, Impagnatiello, Michele, Inchingolo, Riccardo, Intini, Enrica, Iorio, Raffaele, Izzi, Immacolata Maria, Jovanovic, Tamara, Kadhim, Cristina, La Macchia, Rosa, La Milia, Daniele Ignazio, Landi, Francesco, Landi, Giovanni, Landi, Rosario, Landolfi, Raffaele, Leo, Massimo, Leone, Paolo Maria, Levantesi, Laura, Liguori, Antonio, Liperoti, Rosa, Lizzio, Marco Maria, Lo Monaco Maria, Rita, Locantore, Pietro, Lombardi, Francesco, Lombardi, Gianmarco, Lopetuso, Loris, Loria, Valentina, Losito, Angela Raffaella, Lucia, Mothanje Barbara Patricia, Macagno, Francesco, Macerola, Noemi, Maggi, Giampaolo, Maiuro, Giuseppe, Mancarella, Francesco, Mangiola, Francesca, Manno, Alberto, Marchesini, Debora, Maresca, Gian Marco, Marrone, Giuseppe, Martis, Ilaria, Martone, Anna Maria, Marzetti, Emanuele, Mattana, Chiara, Matteo, Maria Valeria, Maviglia, Riccardo, Mazzarella, Ada, Memoli, Carmen, Miele, Luca, Migneco, Alessio, Mignini, Irene, Milani, Alessandro, Milardi, Domenico, Montalto, Massimo, Montemurro, Giuliano, Monti, Flavia, Montini, Luca, Morena, Tony Christian, Morra, Vincenzina, Morretta, Chiara, Moschese, Davide, Murace, Celeste Ambra, Murdolo, Martina, Murri, Rita, Napoli, Marco, Nardella, Elisabetta, Natalello, Gerlando, Natalini, Daniele, Navarra, Simone Maria, Nesci, Antonio, Nicoletti, Alberto, Nicoletti, Rocco, Nicoletti, Tommaso Filippo, Nicolò, Rebecca, Nicolotti, Nicola, Nista, Enrico Celestino, Nuzzo, Eugenia, Oggiano, Marco, Ojetti, Veronica, Pagano, Francesco Cosimo, Paiano, Gianfranco, Pais, Cristina, Pallavicini, Federico, Palombo, Andrea, Paolillo, Federico, Papa, Alfredo, Papanice, Domenico, Papparella, Luigi Giovanni, Paratore, Mattia, Parrinello, Giuseppe, Pasciuto, Giuliana, Pasculli, Pierpaolo, Pecorini, Giovanni, Perniola, Simone, Pero, Erika, Petricca, Luca, Petrucci, Martina, Picarelli, Chiara, Piccioni, Andrea, Piccolo, Annalisa, Piervincenzi, Edoardo, Pignataro, Giulia, Pignataro, Raffaele, Pintaudi, Gabriele, Pisapia, Luca, Pizzoferrato, Marco, Pizzolante, Fabrizio, Pola, Roberto, Policola, Caterina, Pompili, Maurizio, Pontecorvi, Flavia, Pontecorvi, Valerio, Ponziani, Francesca, Popolla, Valentina, Porceddu, Enrica, Porfidia, Angelo, Porro, Lucia Maria, Potenza, Annalisa, Pozzana, Francesca, Privitera, Giuseppe, Pugliese, Daniela, Pulcini, Gabriele, Racco, Simona, Raffaelli, Francesca, Ramunno, Vittoria, Rapaccini, Gian Ludovico, Richeldi, Luca, Rinninella, Emanuele, Rocchi, Sara, Romanò, Bruno, Romano, Stefano, Rosa, Federico, Rossi, Laura, Rossi, Raimondo, Rossini, Enrica, Rota, Elisabetta, Rovedi, Fabiana, Rubino, Carlotta, Rumi, Gabriele, Russo, Andrea, Sabia, Luca, Salerno, Andrea, Salini, Sara, Salvatore, Lucia, Samori, Dehara, Sandroni, Claudio, Sanguinetti, Maurizio, Santarelli, Luca, Santini, Paolo, Santolamazza, Danilo, Santoliquido, Angelo, Santopaolo, Francesco, Santoro, Michele Cosimo, Sardeo, Francesco, Sarnari, Caterina, Saviano, Angela, Saviano, Luisa, Scaldaferri, Franco, Scarascia, Roberta, Schepis, Tommaso, Schiavello, Francesca, Scoppettuolo, Giancarlo, Sedda, Davide, Sessa, Flaminio, Sestito, Luisa, Settanni, Carlo, Siciliano, Matteo, Siciliano, Valentina, Sicuranza, Rossella, Simeoni, Benedetta, Simonetti, Jacopo, Smargiassi, Andrea, Soave, Paolo Maurizio, Sonnino, Chiara, Staiti, Domenico, Stella, Claudia, Stella, Leonardo, Stival, Eleonora, Taddei, Eleonora, Talerico, Rossella, Tamburello, Elio, Tamburrini, Enrica, Tanzarella, Eloisa Sofia, Tarascio, Elena, Tarli, Claudia, Tersali, Alessandra, Tilli, Pietro, Timpano, Jacopo, Torelli, Enrico, Torrini, Flavia, Tosato, Matteo, Tosoni, Alberto, Tricoli, Luca, Tritto, Marcello, Tumbarello, Mario, Tummolo, Anita Maria, Vallecoccia, Maria Sole, Valletta, Federico, Varone, Francesco, Vassalli, Francesco, Ventura, Giulio, Verardi, Lucrezia, Vetrone, Lorenzo, Vetrugno, Giuseppe, Visconti, Elena, Visconti, Felicia, Viviani, Andrea, Zaccaria, Raffaella, Zaccone, Carmelina, Zelano, Lorenzo, Zileri Dal Verme, Lorenzo, and Zuccalà, Giuseppe

Subjects
Male, Hospitalized patients, muscle, Settore M-PSI/02 - PSICOBIOLOGIA E PSICOLOGIA FISIOLOGICA, neurological disorders, 0302 clinical medicine, Hyposmia, 030212 general & internal medicine, Respiratory system, education.field_of_study, Brain Diseases, Headache, virus diseases, Neuromuscular Diseases, Middle Aged, Hospitalization, medicine.anatomical_structure, Neurology, Female, medicine.symptom, Adult, medicine.medical_specialty, SARS‐CoV2, Coronavirus disease 2019 (COVID-19), Patients, Short Communication, Anosmia, precision medicine, Population, Encephalopathy, Short Communications, Clinical Neurology, Settore MED/26, 03 medical and health sciences, COVID‐19, Internal medicine, Throat, Influenza, Human, medicine, Humans, education, Aged, Retrospective Studies, business.industry, SARS-CoV-2, COVID-19, Hypoxia (medical), medicine.disease, respiratory tract diseases, body regions, Neurology (clinical), Nervous System Diseases, business, 030217 neurology & neurosurgery
Abstract

Background and purpose The objective of this study was to assess the neurological manifestations in a series of consecutive severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-positive patients, comparing their frequency with a population hospitalized in the same period for flu/respiratory symptoms, finally not related to SARS-CoV-2. Methods Patients with flu/respiratory symptoms admitted to Fondazione Policlinico Gemelli hospital from 14 March 2020 to 20 April 2020 were retrospectively enrolled. The frequency of neurological manifestations of patients with SARS-CoV-2 infection was compared with a control group. Results In all, 213 patients were found to be positive for SARS-CoV-2, after reverse transcriptase polymerase chain reaction on nasal or throat swabs, whilst 218 patients were found to be negative and were used as a control group. Regarding central nervous system manifestations, in SARS-CoV-2-positive patients a higher frequency of headache, hyposmia and encephalopathy always related to systemic conditions (fever or hypoxia) was observed. Furthermore, muscular involvement was more frequent in SARS-CoV-2 infection. Conclusions Patients with COVID-19 commonly have neurological manifestations but only hyposmia and muscle involvement seem more frequent compared with other flu diseases.

Published
2020

39. The “development of metabolic and functional markers of dementia in older people” (ODINO) study: Rationale, design and methods

Author

Picca, A., Ronconi, D., Coelho-Junior, H. J., Calvani, Riccardo, Marini, F., Biancolillo, A., Gervasoni, Jacopo, Primiano, A., Pais, C., Meloni, E., Fusco, Domenico, Lo Monaco, Maria Rita, Bernabei, Roberto, Camilla Cipriani, M., Marzetti, Emanuele, Liperoti, Rosa, Calvani R. (ORCID:0000-0001-5472-2365), Gervasoni J., Fusco D., Lo Monaco M. R. (ORCID:0000-0002-1457-7981), Bernabei R. (ORCID:0000-0002-9197-004X), Marzetti E. (ORCID:0000-0001-9567-6983), Liperoti R. (ORCID:0000-0003-3740-1687), Picca, A., Ronconi, D., Coelho-Junior, H. J., Calvani, Riccardo, Marini, F., Biancolillo, A., Gervasoni, Jacopo, Primiano, A., Pais, C., Meloni, E., Fusco, Domenico, Lo Monaco, Maria Rita, Bernabei, Roberto, Camilla Cipriani, M., Marzetti, Emanuele, Liperoti, Rosa, Calvani R. (ORCID:0000-0001-5472-2365), Gervasoni J., Fusco D., Lo Monaco M. R. (ORCID:0000-0002-1457-7981), Bernabei R. (ORCID:0000-0002-9197-004X), Marzetti E. (ORCID:0000-0001-9567-6983), and Liperoti R. (ORCID:0000-0003-3740-1687)

Abstract

Mild cognitive impairment (MCI), also termed mild neurocognitive disorder, includes a heterogeneous group of conditions characterized by declines in one or more cognitive domains greater than that expected during "normal" aging but not severe enough to impair functional abilities. MCI has been associated with an increased risk of developing dementia and even considered an early stage of it. Therefore, noninvasively accessible biomarkers of MCI are highly sought after for early identification of the condition. Systemic inflammation, metabolic perturbations, and declining physical performance have been described in people with MCI. However, whether biological and functional parameters differ across MCI neuropsychological subtypes is presently debated. Likewise, the predictive value of existing biomarkers toward MCI conversion into dementia is unclear. The "develOpment of metabolic and functional markers of Dementia IN Older people" (ODINO) study was conceived as a multi-dimensional investigation in which multi-marker discovery will be coupled with innovative statistical approaches to characterize patterns of systemic inflammation, metabolic perturbations, and physical performance in older adults with MCI. The ultimate aim of ODINO is to identify potential biomarkers specific for MCI subtypes and predictive of MCI conversion into Alzheimer's disease or other forms of dementia over a three-year follow-up. Here, we describe the rationale, design, and methods of ODINO.

Published
2020

40. The New Challenge of Geriatrics: Saving Frail Older People from the SARS-COV-2 Pandemic Infection

Author

Landi, Francesco, Barillaro, Christian, Bellieni, Agnese, Brandi, Vincenzo, Carfì, A, D'Angelo, M, Fusco, Domenico, Landi, G, Lo Monaco, Maria Rita, Martone, Anna Maria, Marzetti, Emanuele, Pagano, Francesco Cosimo, Pais, C, Russo, A, Salini, S, Tosato, Matteo, Tummolo, Aida Angela, Benvenuto, F, Bramato, Giulia, Catalano, Lucio, Ciciarello, Francesca, Martis, I, Rocchi, Sara, Rota, E, Salerno, Andrea Maria, Tritto, M, Sgadari, Antonio, Zuccala', Giuseppe, Bernabei, Roberto, Landi, F (ORCID:0000-0002-3472-1389), Barillaro, C, Bellieni, A, Brandi, V, Fusco, D, Lo Monaco, R (ORCID:0000-0002-1457-7981), Martone, A M, Marzetti, E (ORCID:0000-0001-9567-6983), Pagano, F, Tosato, M, Tummolo, A, Bramato, G, Catalano, L, Ciciarello, F, Rocchi, S, Salerno, A, Sgadari, A (ORCID:0000-0002-8296-043X), Zuccalà, G (ORCID:0000-0002-2567-2220), Bernabei, R (ORCID:0000-0002-9197-004X), Landi, Francesco, Barillaro, Christian, Bellieni, Agnese, Brandi, Vincenzo, Carfì, A, D'Angelo, M, Fusco, Domenico, Landi, G, Lo Monaco, Maria Rita, Martone, Anna Maria, Marzetti, Emanuele, Pagano, Francesco Cosimo, Pais, C, Russo, A, Salini, S, Tosato, Matteo, Tummolo, Aida Angela, Benvenuto, F, Bramato, Giulia, Catalano, Lucio, Ciciarello, Francesca, Martis, I, Rocchi, Sara, Rota, E, Salerno, Andrea Maria, Tritto, M, Sgadari, Antonio, Zuccala', Giuseppe, Bernabei, Roberto, Landi, F (ORCID:0000-0002-3472-1389), Barillaro, C, Bellieni, A, Brandi, V, Fusco, D, Lo Monaco, R (ORCID:0000-0002-1457-7981), Martone, A M, Marzetti, E (ORCID:0000-0001-9567-6983), Pagano, F, Tosato, M, Tummolo, A, Bramato, G, Catalano, L, Ciciarello, F, Rocchi, S, Salerno, A, Sgadari, A (ORCID:0000-0002-8296-043X), Zuccalà, G (ORCID:0000-0002-2567-2220), and Bernabei, R (ORCID:0000-0002-9197-004X)

Abstract

No abstract available

Published
2020

41. Tolerability of bevacizumab in elderly ovarian cancer patients (Turbo study): A case-control study of a real-life experience

Author

Amadio, G., Marchetti, Claudia, Villani, Emanuele Rocco, Fusco, Domenico, Stollagli, F., Bottoni, C., Distefano, Maria Grazia, Colloca, Giuseppe Ferdinando, Scambia, Giovanni, Fagotti, Anna, Marchetti C. (ORCID:0000-0001-7098-8956), Villani E. R., Fusco D., Distefano M., Colloca G., Scambia G. (ORCID:0000-0003-2758-1063), Fagotti A. (ORCID:0000-0001-5579-335X), Amadio, G., Marchetti, Claudia, Villani, Emanuele Rocco, Fusco, Domenico, Stollagli, F., Bottoni, C., Distefano, Maria Grazia, Colloca, Giuseppe Ferdinando, Scambia, Giovanni, Fagotti, Anna, Marchetti C. (ORCID:0000-0001-7098-8956), Villani E. R., Fusco D., Distefano M., Colloca G., Scambia G. (ORCID:0000-0003-2758-1063), and Fagotti A. (ORCID:0000-0001-5579-335X)

Abstract

Objective: Bevacizumab maintenance following platinum-based chemotherapy is an effective treatment for epithelial ovarian cancer (EOC), both in primary and recurrent disease. Our aim was to identify criteria to select elderly patients who can safely benefit from bevacizumab addition. Methods: This is a case-control study on patients with primary or recurrent EOC who received platinum-based chemotherapy plus bevacizumab, between January 2015 and December 2016. Patient characteristics, treatment details and adverse events were reviewed and analyzed in 2 settings: younger (<65 years, group 1) and elderly (≥65 years, group 2). A binary logistic model was applied to correlate clinical variables and severe (grade ≥3) toxicity risk. Results: Overall, 283 patients with EOC were included, with 72 (25.4%) older patients compared with 211 (74.6%) younger women. Bevacizumab had been administered to 234 patients (82.7%) as first-line treatment and in 49 (17.3%) with recurrent disease. At diagnosis, elderly patients presented with at least one comorbidity and were taking at least 1 medication in 84.7% and 80.6% of the cases respectively, compared with correspondingly 47.4% and 37.4% in group 1 (p<0.001). Nonetheless, the occurrence of serious (grade ≥3) adverse events did not increase among the older group. Creatinine serum levels >1.1 g/dL, estimated glomerular filtration rate (eGFR) ≤60 mL/min, ≥3 comorbidities were independently associated with a higher severe toxicity. Conclusions: Elderly patients with EOC can safely be treated with bevacizumab; factors other than age, as higher creatinine serum levels, eGFR and number of comorbidities should be considered to better estimate bevacizumab-related toxicity risk.

Published
2020

42. COVID-19 and intestinal inflammation: Role of fecal calprotectin

Author

Ojetti, Veronica, primary, Saviano, Angela, additional, Covino, Marcello, additional, Acampora, Nicola, additional, Troiani, Eliana, additional, Franceschi, Francesco, additional, Abbate, Valeria, additional, Addolorato, Giovanni, additional, Agostini, Fabiana, additional, Ainora, Maria Elena, additional, Akacha, Karim, additional, Amato, Elena, additional, Andreani, Francesca, additional, Andriollo, Gloria, additional, Annetta, Maria Giuseppina, additional, Annicchiarico, Brigida Eleonora, additional, Antonelli, Mariangela, additional, Antonucci, Gabriele, additional, Anzellotti, Gian Marco, additional, Armuzzi, Alessandro, additional, Baldi, Fabiana, additional, Barattucci, Ilaria, additional, Barillaro, Christian, additional, Barone, Fabiana, additional, Bellantone, Rocco Domenico Alfonso, additional, Bellieni, Andrea, additional, Bello, Giuseppe, additional, Benicchi, Andrea, additional, Benvenuto, Francesca, additional, Berardini, Ludovica, additional, Berloco, Filippo, additional, Bernabei, Roberto, additional, Bianchi, Antonio, additional, Biasucci, Daniele Guerino, additional, Biasucci, Luigi Marzio, additional, Bibbò, Stefano, additional, Bini, Alessandra, additional, Bisanti, Alessandra, additional, Biscetti, Federico, additional, Bocci, Maria Grazia, additional, Bonadia, Nicola, additional, Bongiovanni, Filippo, additional, Borghetti, Alberto, additional, Bosco, Giulia, additional, Bosello, Silvia, additional, Bove, Vincenzo, additional, Bramato, Giulia, additional, Brandi, Vincenzo, additional, Bruni, Teresa, additional, Bruno, Carmine, additional, Bruno, Dario, additional, Bungaro, Maria Chiara, additional, Buonomo, Alessandro, additional, Burzo, Livia, additional, Calabrese, Angelo, additional, Calvello, Maria Rosaria, additional, Cambieri, Andrea, additional, Cambise, Chiara, additional, Cammà, Giulia, additional, Candelli, Marcello, additional, Canistro, Gennaro, additional, Cantanale, Antonello, additional, Capalbo, Gennaro, additional, Capaldi, Lorenzo, additional, Capone, Emanuele, additional, Capristo, Esmeralda, additional, Carbone, Luigi, additional, Cardone, Silvia, additional, Carelli, Simone, additional, Carfì, Angelo, additional, Carnicelli, Annamaria, additional, Caruso, Cristiano, additional, Casciaro, Francesco Antonio, additional, Catalano, Lucio, additional, Cauda, Roberto, additional, Cecchini, Andrea Leonardo, additional, Cerrito, Lucia, additional, Cesarano, Melania, additional, Chiarito, Annalisa, additional, Cianci, Rossella, additional, Cicchinelli, Sara, additional, Ciccullo, Arturo, additional, Cicetti, Marta, additional, Ciciarello, Francesca, additional, Cingolani, Antonella, additional, Cipriani, Maria Camilla, additional, Consalvo, Maria Ludovica, additional, Coppola, Gaetano, additional, Corbo, Giuseppe Maria, additional, Corsello, Andrea, additional, Costante, Federico, additional, Costanzi, Matteo, additional, Crupi, Davide, additional, Cutuli, Salvatore Lucio, additional, D'Addio, Stefano, additional, D'Alessandro, Alessia, additional, D'AlfonsoD'Angelo, Maria ElenaEmanuela, additional, D'Aversa, Francesca, additional, Damiano, Fernando, additional, De Berardinis, Gian Maria, additional, De Cunzo, Tommaso, additional, De Gaetano, Donati Katleen, additional, De Luca, Giulio, additional, De Matteis, Giuseppe, additional, De Pascale, Gennaro, additional, De Santis, Paolo, additional, De Siena, Martina, additional, De Vito, Francesco, additional, Del Gatto, Valeria, additional, Del Giacomo, Paola, additional, Del Zompo, Fabio, additional, Dell'Anna, Antonio Maria, additional, Polla, Davide Della, additional, Di Gialleonardo, Luca, additional, Di Giambenedetto, Simona, additional, Di Luca, Roberta, additional, Di Maurizio, Luca, additional, Di Muro, Mariangela, additional, Dusina, Alex, additional, Eleuteri, Davide, additional, Esperide, Alessandra, additional, Fachechi, Daniele, additional, Faliero, Domenico, additional, Falsiroli, Cinzia, additional, Fantoni, Massimo, additional, Fedele, Annalaura, additional, Feliciani, Daniela, additional, Ferrante, Cristina, additional, Ferrone, Giuliano, additional, Festa, Rossano, additional, Fiore, Maria Chiara, additional, Flex, Andrea, additional, Forte, Evelina, additional, Francesconi, Alessandra, additional, Franza, Laura, additional, Funaro, Barbara, additional, Fuorlo, Mariella, additional, Fusco, Domenico, additional, Gabrielli, Maurizio, additional, Gaetani, Eleonora, additional, Galletta, Claudia, additional, Gallo, Antonella, additional, Gambassi, Giovanni, additional, Garcovich, Matteo, additional, Gasbarrini, Antonio, additional, Gasparrini, Irene, additional, Gelli, Silvia, additional, Giampietro, Antonella, additional, Gigante, Laura, additional, Giuliano, Gabriele, additional, Giuliano, Giorgia, additional, Giupponi, Bianca, additional, Gremese, Elisa, additional, Grieco, Domenico Luca, additional, Guerrera, Manuel, additional, Guglielmi, Valeria, additional, Guidone, Caterina, additional, Gullì, Antonio, additional, Iaconelli, Amerigo, additional, Iafrati, Aurora, additional, Ianiro, Gianluca, additional, Iaquinta, Angela, additional, Impagnatiello, Michele, additional, Inchingolo, Riccardo, additional, Intini, Enrica, additional, Iorio, Raffaele, additional, Izzi, Immacolata Maria, additional, Jovanovic, Tamara, additional, Kadhim, Cristina, additional, La Macchia, Rosa, additional, La Milia, Daniele Ignazio, additional, Landi, Francesco, additional, Landi, Giovanni, additional, Landi, Rosario, additional, Landolfi, Raffaele, additional, Leo, Massimo, additional, Leone, Paolo Maria, additional, Levantesi, Laura, additional, Liguori, Antonio, additional, Liperoti, Rosa, additional, Lizzio, Marco Maria, additional, Monaco, Maria Rita Lo, additional, Locantore, Pietro, additional, Lombardi, Francesco, additional, Lombardi, Gianmarco, additional, Lopetuso, Loris, additional, Loria, Valentina, additional, Losito, Angela Raffaella, additional, Lucia, Mothanje Barbara Patricia, additional, Macagno, Francesco, additional, Macerola, Noemi, additional, Maggi, Giampaolo, additional, Maiuro, Giuseppe, additional, Mancarella, Francesco, additional, Mangiola, Francesca, additional, Manno, Alberto, additional, Marchesini, Debora, additional, Maresca, Gian Marco, additional, Marrone, Giuseppe, additional, Martis, Ilaria, additional, Martone, Anna Maria, additional, Marzetti, Emanuele, additional, Mattana, Chiara, additional, Matteo, Maria Valeria, additional, Maviglia, Riccardo, additional, Mazzarella, Ada, additional, Memoli, Carmen, additional, Miele, Luca, additional, Migneco, Alessio, additional, Mignini, Irene, additional, Milani, Alessandro, additional, Milardi, Domenico, additional, Montalto, Massimo, additional, Montemurro, Giuliano, additional, Monti, Flavia, additional, Montini, Luca, additional, Morena, Tony Christian, additional, Morra, Vincenzina, additional, Morretta, Chiara, additional, Moschese, Davide, additional, Murace, Celeste Ambra, additional, Murdolo, Martina, additional, Murri, Rita, additional, Napoli, Marco, additional, Nardella, Elisabetta, additional, Natalello, Gerlando, additional, Natalini, Daniele, additional, Navarra, Simone Maria, additional, Nesci, Antonio, additional, Nicoletti, Alberto, additional, Nicoletti, Rocco, additional, Nicoletti, Tommaso Filippo, additional, Nicolò, Rebecca, additional, Nicolotti, Nicola, additional, Nista, Enrico Celestino, additional, Nuzzo, Eugenia, additional, Oggiano, Marco, additional, Ojetti, Veronica, additional, Pagano, Francesco Cosimo, additional, Paiano, Gianfranco, additional, Pais, Cristina, additional, Pallavicini, Federico, additional, Palombo, Andrea, additional, Paolillo, Federico, additional, Papa, Alfredo, additional, Papanice, Domenico, additional, Papparella, Luigi Giovanni, additional, Paratore, Mattia, additional, Parrinello, Giuseppe, additional, Pasciuto, Giuliana, additional, Pasculli, Pierpaolo, additional, Pecorini, Giovanni, additional, Perniola, Simone, additional, Pero, Erika, additional, Petricca, Luca, additional, Petrucci, Martina, additional, Picarelli, Chiara, additional, Piccioni, Andrea, additional, Piccolo, Annalisa, additional, Piervincenzi, Edoardo, additional, Pignataro, Giulia, additional, Pignataro, Raffaele, additional, Pintaudi, Gabriele, additional, Pisapia, Luca, additional, Pizzoferrato, Marco, additional, Pizzolante, Fabrizio, additional, Pola, Roberto, additional, Policola, Caterina, additional, Pompili, Maurizio, additional, Pontecorvi, Flavia, additional, Pontecorvi, Valerio, additional, Ponziani, Francesca, additional, Popolla, Valentina, additional, Porceddu, Enrica, additional, Porfidia, Angelo, additional, Porro, Lucia Maria, additional, Potenza, Annalisa, additional, Pozzana, Francesca, additional, Privitera, Giuseppe, additional, Pugliese, Daniela, additional, Pulcini, Gabriele, additional, Racco, Simona, additional, Raffaelli, Francesca, additional, Ramunno, Vittoria, additional, Rapaccini, Gian Ludovico, additional, Richeldi, Luca, additional, Rinninella, Emanuele, additional, Rocchi, Sara, additional, Romanò, Bruno, additional, Romano, Stefano, additional, Rosa, Federico, additional, Rossi, Laura, additional, Rossi, Raimondo, additional, Rossini, Enrica, additional, Rota, Elisabetta, additional, Rovedi, Fabiana, additional, Rubino, Carlotta, additional, Rumi, Gabriele, additional, Russo, Andrea, additional, Sabia, Luca, additional, Salerno, Andrea, additional, Salini, Sara, additional, Salvatore, Lucia, additional, Samori, Dehara, additional, Sandroni, Claudio, additional, Sanguinetti, Maurizio, additional, Santarelli, Luca, additional, Santini, Paolo, additional, Santolamazza, Danilo, additional, Santoliquido, Angelo, additional, Santopaolo, Francesco, additional, Santoro, Michele Cosimo, additional, Sardeo, Francesco, additional, Sarnari, Caterina, additional, Saviano, Luisa, additional, Scaldaferri, Franco, additional, Scarascia, Roberta, additional, Schepis, Tommaso, additional, Schiavello, Francesca, additional, Scoppettuolo, Giancarlo, additional, Sedda, Davide, additional, Sessa, Flaminio, additional, Sestito, Luisa, additional, Settanni, Carlo, additional, Siciliano, Matteo, additional, Siciliano, Valentina, additional, Sicuranza, Rossella, additional, Simeoni, Benedetta, additional, Simonetti, Jacopo, additional, Smargiassi, Andrea, additional, Soave, Paolo Maurizio, additional, Sonnino, Chiara, additional, Staiti, Domenico, additional, Stella, Claudia, additional, Stella, Leonardo, additional, Stival, Eleonora, additional, Taddei, Eleonora, additional, Talerico, Rossella, additional, Tamburello, Elio, additional, Tamburrini, Enrica, additional, Tanzarella, Eloisa Sofia, additional, Tarascio, Elena, additional, Tarli, Claudia, additional, Tersali, Alessandra, additional, Tilli, Pietro, additional, Timpano, Jacopo, additional, Torelli, Enrico, additional, Torrini, Flavia, additional, Tosato, Matteo, additional, Tosoni, Alberto, additional, Tricoli, Luca, additional, Tritto, Marcello, additional, Tumbarello, Mario, additional, Tummolo, Anita Maria, additional, Vallecoccia, Maria Sole, additional, Valletta, Federico, additional, Varone, Francesco, additional, Vassalli, Francesco, additional, Ventura, Giulio, additional, Verardi, Lucrezia, additional, Vetrone, Lorenzo, additional, Vetrugno, Giuseppe, additional, Visconti, Elena, additional, Visconti, Felicia, additional, Viviani, Andrea, additional, Zaccaria, Raffaella, additional, Zaccone, Carmelina, additional, Zelano, Lorenzo, additional, Dal Verme, Lorenzo Zileri, additional, and Zuccalà, Giuseppe, additional

Published
2020
Full Text
View/download PDF

47. What about the caregiver? A journey into Parkinson’s disease following the burden tracks

Author

Lo Monaco, Maria Rita, primary, Di Stasio, Enrico, additional, Ricciardi, Diego, additional, Solito, Marcella, additional, Petracca, Martina, additional, Fusco, Domenico, additional, Onder, Graziano, additional, Landi, Giovanni, additional, Zuccalà, Giuseppe, additional, Liperoti, Rosa, additional, Cipriani, Maria Camilla, additional, Brisi, Caterina, additional, Bernabei, Roberto, additional, Silveri, Maria Caterina, additional, and Bentivoglio, Anna Rita, additional

Published
2020
Full Text
View/download PDF

48. The “develOpment of metabolic and functional markers of Dementia IN Older people” (ODINO) Study: Rationale, Design and Methods

Author

Picca, Anna, primary, Ronconi, Daniela, additional, Coelho-Junior, Hélio J., additional, Calvani, Riccardo, additional, Marini, Federico, additional, Biancolillo, Alessandra, additional, Gervasoni, Jacopo, additional, Primiano, Aniello, additional, Pais, Cristina, additional, Meloni, Eleonora, additional, Fusco, Domenico, additional, Lo Monaco, Maria Rita, additional, Bernabei, Roberto, additional, Cipriani, Maria Camilla, additional, Marzetti, Emanuele, additional, and Liperoti, Rosa, additional

Published
2020
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results