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15 results on '"Furuta, Haruka"'

10. 副作用の軽減策を臨床ビッグデータから探す : オランザピン誘発高血糖のビタミンDによる予防

Author

Konaka, Yuina, Furuta, Haruka, Nagashima, Takuya, and Kaneko, Shuji

Subjects
ビタミンD, 有害事象, Adverse effects, atypical antipsychotics, olanzapine, vitamin D, hyperglycemia, 非定型統合失調症治療薬, 高血糖, オランザピン
Abstract

Every pharmaceutical agent has both directions of effects; that is, therapeutic main effects and undesirable adverse effects. Surveillance of adverse drug reactions has been performed in the post-marketing period by collecting self-reports of clinical cases in which some of adverse events are observed. FDA Adverse Event Reporting System (FAERS) is one of the publicly available databases of adverse event cases. To find a practical solution for reducing adverse events, we have shown that FAERS can be used for finding a drug combination in which the odds ratio of adverse events is statistically lowered with a concomitant drug. In the present study, we focused on the atypical antipsychotic olanzapine, which frequently causes hyperglycemia in patients. Our analysis of FAERS lead to a hypothesis that olanzapine-induced hyperglycemia is mitigated by concomitant use of vitamin D. Subsequent in vitro experiment using cultured myocytes demonstrated that olanzapine induces insulin resistance that can be prevented by vitamin D pretreatment., 薬には本来の効能である主作用と望ましくない有害作用(副作用)がある. この副作用は市販後にモニターされており, 有害事象のセルフレポートとして蓄積されている. 米国食品医薬品局FDAが公開している副作用報告データFAERSでは世界中で起こった有害事象例が検証できる. 我々はこれまで有害事象を減らす実際的な方策として, FAERSを用いて特定の副作用を軽減する併用薬を探索することが可能であることを示してきた. そこで本研究では, 非定型統合失調治療薬であるオランザピンの副作用として知られる高血糖に着目した. 我々が行ったFAERSの解析から, オランザピンが誘発する高血糖はビタミンDの併用によって改善するという仮説が導出された. さらに培養骨格筋細胞を用いた実験により, オランザピンが誘発するインスリン抵抗性がビタミンD前処置で改善されることが実証された.

Published
2018

11. IRS-2 deubiquitination by USP9X maintains anchorage-independent cell growth via Erk1/2 activation in prostate carcinoma cell line

Author

Furuta, Haruka, primary, Yoshihara, Hidehito, additional, Fukushima, Toshiaki, additional, Yoneyama, Yosuke, additional, Ito, Akihiro, additional, Worrall, Claire, additional, Girnita, Ada, additional, Girnita, Leonard, additional, Yoshida, Minoru, additional, Asano, Tomoichiro, additional, Komada, Masayuki, additional, Kataoka, Naoyuki, additional, Chida, Kazuhiro, additional, Hakuno, Fumihiko, additional, and Takahashi, Shin-Ichiro, additional

Published
2018
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15. Nedd4-induced monoubiquitination of IRS-2 enhances IGF signalling and mitogenic activity

Author

Fukushima, Toshiaki, primary, Yoshihara, Hidehito, additional, Furuta, Haruka, additional, Kamei, Hiroyasu, additional, Hakuno, Fumihiko, additional, Luan, Jing, additional, Duan, Cunming, additional, Saeki, Yasushi, additional, Tanaka, Keiji, additional, Iemura, Shun-Ichiro, additional, Natsume, Tohru, additional, Chida, Kazuhiro, additional, Nakatsu, Yusuke, additional, Kamata, Hideaki, additional, Asano, Tomoichiro, additional, and Takahashi, Shin-Ichiro, additional

Published
2015
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