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1. Optimization of smartphone psychotherapy for depression and anxiety among patients with cancer using the multiphase optimization strategy (MOST) framework and decentralized clinical trial system (SMartphone Intervention to LEssen depression/Anxiety and GAIN resilience: SMILE AGAIN project): a protocol for a randomized controlled trial

Author

Uchida, Megumi, Furukawa, Toshiaki A, Yamaguchi, Takuhiro, Imai, Fuminobu, Momino, Kanae, Katsuki, Fujika, Sakurai, Naomi, Miyaji, Tempei, Horikoshi, Masaru, Iwata, Hiroji, Zenda, Sadamoto, Iwatani, Tsuguo, Ogawa, Asao, Inoue, Akira, Abe, Masakazu, Toyama, Tatsuya, Uchitomi, Yosuke, Matsuoka, Hiromichi, Noma, Hisashi, and Akechi, Tatsuo

Published
2023
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5. Time for united action on depression: a Lancet–World Psychiatric Association Commission

Author

Herrman, Helen, Patel, Vikram, Kieling, Christian, Berk, Michael, Buchweitz, Claudia, Cuijpers, Pim, Furukawa, Toshiaki A, Kessler, Ronald C, Kohrt, Brandon A, Maj, Mario, McGorry, Patrick, Reynolds, Charles F, III, Weissman, Myrna M, Chibanda, Dixon, Dowrick, Christopher, Howard, Louise M, Hoven, Christina W, Knapp, Martin, Mayberg, Helen S, Penninx, Brenda W J H, Xiao, Shuiyuan, Trivedi, Madhukar, Uher, Rudolf, Vijayakumar, Lakshmi, and Wolpert, Miranda

Published
2022
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9. Optimizing smartphone psychotherapy for depressive symptoms in patients with cancer: Multiphase optimization strategy using a decentralized multicenter randomized clinical trial (J‐SUPPORT 2001 Study).

Author

Akechi, Tatsuo, Furukawa, Toshiaki A., Noma, Hisashi, Iwata, Hiroji, Toyama, Tatsuya, Higaki, Kenji, Matsuoka, Hiromichi, Zenda, Sadamoto, Iwatani, Tsuguo, Akahane, Kazuhisa, Inoue, Akira, Sagara, Yasuaki, Uchida, Megumi, Imai, Fuminobu, Momino, Kanae, Imaizumi, Gen, Yamaguchi, Takuhiro, Mashiko, Tomoe, Miyaji, Tempei, and Horikoshi, Masaru

Subjects
*MENTAL depression, *PSYCHOTHERAPY, *COGNITIVE therapy, *CANCER patients, *CLINICAL trials
Abstract

Aim: Patients with cancer experience various forms of psychological distress, including depressive symptoms, which can impact quality of life, elevate morbidity risk, and increase medical costs. Psychotherapy and pharmacotherapy are effective for reducing depressive symptoms among patients with cancer, but most patients prefer psychotherapy. This study aimed to develop an efficient and effective smartphone psychotherapy component to address depressive symptom. Methods: This was a decentralized, parallel‐group, multicenter, open, individually randomized, fully factorial trial. Patients aged ≥20 years with cancer were randomized by the presence/absence of three cognitive‐behavioral therapy (CBT) skills (behavioral activation [BA], assertiveness training [AT], and problem‐solving [PS]) on a smartphone app. All participants received psychoeducation (PE). The primary outcome was change in the patient health questionnaire‐9 (PHQ‐9) total score between baseline and week 8. Secondary outcomes included anxiety. Results: In total, 359 participants were randomized. Primary outcome data at week 8 were obtained for 355 participants (99%). The week 8 PHQ‐9 total score was significantly reduced from baseline for all participants by −1.41 points (95% confidence interval [CI] −1.89, −0.92), but between‐group differences in change scores were not significant (BA: −0.04, 95% CI −0.75, 0.67; AT: −0.16, 95% CI −0.87, 0.55; PS: −0.19, 95% CI −0.90, 0.52). Conclusion: As the presence of any of the three intervention components did not contribute to a significant additive reduction of depressive symptoms, we cannot make evidence‐based recommendations regarding the use of specific smartphone psychotherapy. [ABSTRACT FROM AUTHOR]

Published
2024
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11. Optimal sampling in derivation studies was associated with improved discrimination in external validation for heart failure prognostic models

Author

Iwakami, Naotsugu, Nagai, Toshiyuki, Furukawa, Toshiaki A., Tajika, Aran, Onishi, Akira, Nishimura, Kunihiro, Ogata, Soshiro, Nakai, Michikazu, Takegami, Misa, Nakano, Hiroki, Kawasaki, Yohei, Alba, Ana Carolina, Guyatt, Gordon Henry, Shiraishi, Yasuyuki, Kohsaka, Shun, Kohno, Takashi, Goda, Ayumi, Mizuno, Atsushi, Yoshikawa, Tsutomu, and Anzai, Toshihisa

Published
2020
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16. Fingertip advanced glycation end products and psychotic symptoms among adolescents

Author

Miyashita, Mitsuhiro, Yamasaki, Syudo, Ando, Shuntaro, Suzuki, Kazuhiro, Toriumi, Kazuya, Horiuchi, Yasue, Yoshikawa, Akane, Imai, Atsushi, Nagase, Yukihiro, Miyano, Yasuhiro, Inoue, Tomoko, Endo, Kaori, Morimoto, Yuko, Morita, Masaya, Kiyono, Tomoki, Usami, Satoshi, Okazaki, Yuji, Furukawa, Toshiaki A., Hiraiwa-Hasegawa, Mariko, Itokawa, Masanari, Kasai, Kiyoto, Nishida, Atsushi, and Arai, Makoto

Published
2021
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21. Uncovering associations between gender nonconformity, psychosocial factors, and mental health in adolescents: a birth cohort study.

Author

Narita, Zui, DeVylder, Jordan, Yamasaki, Syudo, Ando, Shuntaro, Endo, Kaori, Miyashita, Mitsuhiro, Yamaguchi, Satoshi, Usami, Satoshi, Stanyon, Daniel, Knowles, Gemma, Hiraiwa-Hasegawa, Mariko, Furukawa, Toshiaki A, Kasai, Kiyoto, and Nishida, Atsushi

Subjects
GENDER-nonconforming people, STATISTICAL correlation, MENTAL health, GENDER identity, RESEARCH funding, STATISTICAL sampling, DESCRIPTIVE statistics, FAMILY relations, LONELINESS, LONGITUDINAL method, SURVEYS, CRIME victims, RESEARCH, CONFIDENCE intervals, FACTOR analysis, MENTAL depression, PSYCHOSOCIAL factors, ADOLESCENCE
Abstract

Background: Little information is available on the association between gender nonconformity during adolescence and subsequent mental health. While the distress related to gender nonconformity may be socially produced rather than attributed to individual-level factors, further research is needed to better understand the role of psychosocial factors in this context. Method: We analyzed data from the Tokyo Teen Cohort, obtained through random sampling of adolescents born between 2002 and 2004. We used inverse probability weighting to examine the association of gender nonconformity at ages 12 and 14 as a time-varying variable with subsequent mental health at age 16, while accounting for time-fixed and time-varying confounders. Furthermore, we used a weighting approach to investigate the mediating role of modifiable psychosocial factors in this association, addressing exposure-mediator and mediator–mediator interactions. Results: A total of 3171 participants were analyzed. Persistent gender nonconforming behavior at ages 12 and 14 was associated with subsequent depression (β = 2.02, 95% confidence interval [CI] 0.85 to 3.19) and psychotic experiences (β = 0.33, 95% CI 0.14 to 0.52) at age 16. The results remained robust in sensitivity analyses. Approximately 30% of the association between gender nonconformity and depression was consistently mediated by a set of psychosocial factors, namely loneliness, bullying victimization, and relationships with mother, father, and friends. Conclusions: Persistent gender nonconformity during adolescence is associated with subsequent mental health. Psychosocial factors play a vital mediating role in this association, highlighting the essential need for social intervention and change to reduce stigmatization and ameliorate mental health challenges. [ABSTRACT FROM AUTHOR]

Published
2024
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22. Uncovering associations between gender nonconformity, psychosocial factors, and mental health in adolescents: a birth cohort study

Author

Narita, Zui, primary, DeVylder, Jordan, additional, Yamasaki, Syudo, additional, Ando, Shuntaro, additional, Endo, Kaori, additional, Miyashita, Mitsuhiro, additional, Yamaguchi, Satoshi, additional, Usami, Satoshi, additional, Stanyon, Daniel, additional, Knowles, Gemma, additional, Hiraiwa-Hasegawa, Mariko, additional, Furukawa, Toshiaki A, additional, Kasai, Kiyoto, additional, and Nishida, Atsushi, additional

Published
2023
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26. Psychosocial interventions for the prevention of self-harm repetition: protocol for a systematic review and network meta-analysis

Author

Orri, Massimiliano, primary, Gifuni, Anthony J, additional, Ougrin, Dennis, additional, Boruff, Jill, additional, Cipriani, Andrea, additional, Furukawa, Toshiaki A, additional, Schaffer, Dalia, additional, Del Giovane, Cinzia, additional, Inja, Ayla, additional, Turecki, Gustavo, additional, Geoffroy, Marie-Claude, additional, and Cortese, Samuele, additional

Published
2023
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27. Imiquimod for Cervical and Vaginal Intraepithelial Neoplasia

Author

Inayama, Yoshihide, primary, Takamatsu, Shiro, additional, Hamanishi, Junzo, additional, Mizuno, Kayoko, additional, Horinouchi, Noboru, additional, Yamanoi, Koji, additional, Taki, Mana, additional, Murakami, Ryusuke, additional, Yamaguchi, Ken, additional, Kosaka, Kenzo, additional, Efthimiou, Orestis, additional, Kawakami, Koji, additional, Furukawa, Toshiaki A., additional, and Mandai, Masaki, additional

Published
2023
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31. Imiquimod for Cervical and Vaginal Intraepithelial Neoplasia: A Systematic Review and Meta-analysis

Author

Inayama, Yoshihide, Takamatsu, Shiro, Hamanishi, Junzo, Mizuno, Kayoko, Horinouchi, Noboru, Yamanoi, Koji, Taki, Mana, Murakami, Ryusuke, Yamaguchi, Ken, Kosaka, Kenzo, Efthimiou, Orestis, Kawakami, Koji, Furukawa, Toshiaki A, and Mandai, Masaki

Subjects
360 Social problems & social services, 610 Medicine & health
Abstract

OBJECTIVE To evaluate the treatment efficacy and the risk of adverse events of imiquimod for cervical intraepithelial neoplasia (CIN) and vaginal intraepithelial neoplasia (VAIN), compared with placebo or no intervention. DATA SOURCES We searched Cochrane, PubMed, ISRCTN registry, ClinicalTrials.gov, and the World Health Organization International Clinical Trials Registry Platform up to November 23, 2022. METHODS OF STUDY SELECTION We included randomized controlled trials and prospective nonrandomized studies with control arms that investigated the efficacy of imiquimod for histologically confirmed CIN or VAIN. The primary outcomes were histologic regression of the disease (primary efficacy outcome) and treatment discontinuation due to side effects (primary safety outcome). We estimated pooled odds ratios (ORs) of imiquimod, compared with placebo or no intervention. We also conducted a meta-analysis of the proportions of patients with adverse events in the imiquimod arms. TABULATION, INTEGRATION, AND RESULTS Four studies contributed to the pooled OR for the primary efficacy outcome. An additional four studies were available for meta-analyses of proportions in the imiquimod arm. Imiquimod was associated with increased probability of regression (pooled OR 4.05, 95% CI 2.08-7.89). Pooled OR for CIN in the three studies was 4.27 (95% CI 2.11-8.66); results of one study were available for VAIN (OR, 2.67, 95% CI 0.36-19.71). Pooled probability for primary safety outcome in the imiquimod arm was 0.07 (95% CI 0.03-0.14). The pooled probabilities (95% CI) of secondary outcomes were 0.51 (0.20-0.81) for fever, 0.53 (0.31-0.73) for arthralgia or myalgia, 0.31 (0.18-0.47) for abdominal pain, 0.28 (0.09-0.61) for abnormal vaginal discharge or genital bleeding, 0.48 (0.16-0.82) for vulvovaginal pain, and 0.02 (0.01-0.06) for vaginal ulceration. CONCLUSION Imiquimod was found to be effective for CIN, whereas data on VAIN were limited. Although local and systemic complications are common, treatment discontinuation is infrequent. Thus, imiquimod is potentially an alternative therapy to surgery for CIN. SYSTEMATIC REVIEW REGISTRATION PROSPERO, CRD42022377982.

Published
2023

32. Development of a model to predict combined antidepressant medication and psychotherapy treatment response for depression among veterans

Author

Bossarte, Robert M., primary, Ross, Eric L., additional, Liu, Howard, additional, Turner, Brett, additional, Bryant, Corey, additional, Zainal, Nur Hani, additional, Puac-Polanco, Victor, additional, Ziobrowski, Hannah N., additional, Cui, Ruifeng, additional, Cipriani, Andrea, additional, Furukawa, Toshiaki A., additional, Leung, Lucinda B., additional, Joormann, Jutta, additional, Nierenberg, Andrew A., additional, Oslin, David W., additional, Pigeon, Wilfred R., additional, Post, Edward P., additional, Zaslavsky, Alan M., additional, Zubizarreta, Jose R., additional, Luedtke, Alex, additional, Kennedy, Chris J., additional, and Kessler, Ronald C., additional

Published
2023
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33. Measuring the performance of prediction models to personalize treatment choice

Author

Efthimiou, Orestis, Hoogland, Jeroen, Debray, Thomas P A, Seo, Michael, Furukawa, Toshiaki A, Egger, Matthias, White, Ian R, and Epidemiology and Data Science

Subjects
Statistics and Probability, Epidemiology, 360 Social problems & social services, 360 Soziale Probleme, Sozialdienste, 610 Medicine & health, 610 Medizin und Gesundheit
Abstract

When data are available from individual patients receiving either a treatment or a control intervention in a randomized trial, various statistical and machine learning methods can be used to develop models for predicting future outcomes under the two conditions, and thus to predict treatment effect at the patient level. These predictions can subsequently guide personalized treatment choices. Although several methods for validating prediction models are available, little attention has been given to measuring the performance of predictions of personalized treatment effect. In this article, we propose a range of measures that can be used to this end. We start by defining two dimensions of model accuracy for treatment effects, for a single outcome: discrimination for benefit and calibration for benefit. We then amalgamate these two dimensions into an additional concept, decision accuracy, which quantifies the model's ability to identify patients for whom the benefit from treatment exceeds a given threshold. Subsequently, we propose a series of performance measures related to these dimensions and discuss estimating procedures, focusing on randomized data. Our methods are applicable for continuous or binary outcomes, for any type of prediction model, as long as it uses baseline covariates to predict outcomes under treatment and control. We illustrate all methods using two simulated datasets and a real dataset from a trial in depression. We implement all methods in the R package predieval. Results suggest that the proposed measures can be useful in evaluating and comparing the performance of competing models in predicting individualized treatment effect.

Published
2023

34. Variability in antidepressant response lower for SSRIs and in recent studies

Author

Furukawa, Toshiaki A. and Mulsant, Benoit H.

Subjects
Medical research, Medicine, Experimental, Antidepressants, Tricyclic, Depression, Mental, Serotonin uptake inhibitors, Pharmaceuticals and cosmetics industries, Health, Psychology and mental health
Abstract

* A meta-analysis compared variability in response to antidepressants and placebo in patients with depression, also assessing variability based on depression severity, antidepressant class, and date of study publication. * The primary analysis found there was 14% more variability in antidepressant response compared with placebo response. * Depression severity did not moderate variability in response, while there was lower variability in response to selective serotonin reuptake inhibitors and in more recent studies., A meta-analysis based on 87 antidepressant trials has concluded that there is significantly more variability in participant response to antidepressants than to placebo. The results of the analysis lend support [...]

Published
2020

35. Trends in Prescribing Antipsychotics for Children and Adolescents in Japan: A Descriptive Epidemiological Study Using a Large-Scale Pharmacy Dataset.

Author

Nakane, Sayuri, Tanaka-Mizuno, Sachiko, Nishiyama, Chika, Kochi, Kenji, Yamamoto-Sasaki, Madoka, Takeuchi, Masato, Ogawa, Yusuke, Doi, Yuko, Arai, Masaru, Fujii, Yosuke, Matsunaga, Toshiyuki, Furukawa, Toshiaki A., and Kawakami, Koji

Subjects
CONCOMITANT drugs, ANTIPSYCHOTIC agents, PHARMACY, TEENAGERS, PSYCHIATRIC drugs
Abstract

Little is known about antipsychotic prescription patterns among children and adolescents in Japan, particularly in outpatient settings. We investigated the prevalence and trends of antipsychotic prescription for outpatients aged ≤ 17 years receiving a first antipsychotic prescription from 2006 to 2012 based on a large-scale dispensation dataset. Measurements included age, sex, department of diagnosis and treatment, type of prescription (monotherapy or polytherapy), antipsychotic dosage, and concomitant psychotropic drugs. Of the 10,511 patients, 65.1% were aged 13–17 years, and 52.9% were males. Second-generation antipsychotic monotherapy prescriptions increased from 53.8% in 2006 to 78.3% in 2012. Risperidone was the most frequently prescribed antipsychotic, followed by aripiprazole and olanzapine. Approximately 25.0% of patients were prescribed an initial dose less than recommended. Second-generation antipsychotic monotherapy is currently the most frequent prescription pattern among outpatients aged ≤ 17 years receiving an initial antipsychotic prescription. [ABSTRACT FROM AUTHOR]

Published
2023
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41. Behavioral change stage might moderate the impact of multifaceted interventions on non‐attendance from medical care among patients with type 2 diabetes: The Japan Diabetes Outcome Intervention Trial‐2 Large‐Scale Trial 007 (J‐DOIT2‐LT007)

Author

Bouchi, Ryotaro, Noda, Mitsuhiko, Hayashino, Yasuaki, Goto, Atsushi, Yamazaki, Katsuya, Suzuki, Hikari, Furukawa, Toshiaki A, Izumi, Kazuo, and Kobayashi, Masashi

Subjects
MEDICAL care, TYPE 2 diabetes, DIABETES, PEOPLE with diabetes, MEDICAL societies
Abstract

Aims/Introduction: Non‐attendance from regular medical care is a major problem in diabetes patients. This study aimed to examine the impact of a multifaceted lifestyle intervention by face‐to‐face approach (FFA) on non‐attendance from regular medical care in comparison with that by telephone from the technical support center (TSC). Materials and Methods: This was secondary analysis from a 1‐year, prospective, cluster randomized, intervention study. Patients with type 2 diabetes, who were regularly visiting primary care physicians cluster‐randomized into the control or intervention (TSC or FFA according to resource availability of the district medical associations) groups, were consecutively recruited. The primary end‐point was non‐attendance from regular medical care. The interaction between the type of intervention (TSC vs FFA) and behavioral change stage (pre‐ vs post‐action stage) in diet and exercise for the dropout rate was assessed. Results: Among the 1,915 participants (mean age 56 ± 6 years; 36% women) enrolled, 828, 564 and 264 patients belonged to the control, TSC and FFA groups, respectively. We found evidence suggestive of an interaction between the intervention type and behavioral change stage in diet (P = 0.042) and exercise (P = 0.038) after adjusting for covariates. The hazard ratios (95% confidence interval) of FFA to TSC were 0.21 (0.05–0.93) and 7.69 (0.50–117.78) in the pre‐action and post‐action stages for diet, respectively, whereas they were 0.20 (0.05–0.92) and 4.75 (0.29–73.70) in the pre‐action and post‐action stages for exercise. Conclusions: Among diabetes patients, the impact of multifaceted intervention on non‐attendance from medical care might differ by the behavioral change stage. [ABSTRACT FROM AUTHOR]

Published
2023
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44. Humor-ing the Local: Multivocal Performance in Stand-Up Comedy in Hawai'i

Author

Furukawa, Toshiaki

Abstract

This dissertation takes a discursive approach to Hawai'i stand-up comedy, which is a highly dramaturgical genre, and it examines the cultural specificity of Hawaii comedy in an explicitly interactional context. This culturally-specific performative genre is a discursive site where comedians and their audiences jointly construct multivocal humor through a body of shared knowledge and ideology about linguistic forms, styles, and identities. The dissertation conceptualizes how language, interaction, and social structure are ideologically mediated by one another, and it examines how the comedians use various codes, such as Pidgin and English, and other historically loaded semiotic resources, such as place names, in the moment-by-moment development of performance. Using these inferentially rich semiotic resources, the Local comedians--Frank DeLima, Andy Bumatai, Augie T, Bo Irvine, and others--build interpersonal relationships with their Local and non-Local audiences, invoke intertextual links with past and relevant texts about Hawai'i and its relation to the continental United States, and successfully draw laughter from their audiences. My data collection included obtaining not only performance but also meta-performance data to demonstrate the way the comedians and their audiences conduct multilingual categorial work to make sense of the cultural specificity of Hawai'i humor. Based on meta-performance data taken from interviews and focus groups, the dissertation also investigates the reception of Hawai'i comedy in order to expand this relatively underdeveloped area in sociolinguistics and discourse analysis. A claim is made that multilingual, multiracial, multicultural Hawai'i comedy constitutes an ideological niche and complicates our understanding of sociolinguistic and discourse analytic ideas such as performativity, multivocality, and stylization. [The dissertation citations contained here are published with the permission of ProQuest LLC. Further reproduction is prohibited without permission. Copies of dissertations may be obtained by Telephone (800) 1-800-521-0600. Web page: http://www.proquest.com/en-US/products/dissertations/individuals.shtml.]

Published
2011

46. Development of a model to predict antidepressant treatment response for depression among Veterans

Author

Puac-Polanco, Victor, primary, Ziobrowski, Hannah N., additional, Ross, Eric L., additional, Liu, Howard, additional, Turner, Brett, additional, Cui, Ruifeng, additional, Leung, Lucinda B., additional, Bossarte, Robert M., additional, Bryant, Corey, additional, Joormann, Jutta, additional, Nierenberg, Andrew A., additional, Oslin, David W., additional, Pigeon, Wilfred R., additional, Post, Edward P., additional, Zainal, Nur Hani, additional, Zaslavsky, Alan M., additional, Zubizarreta, Jose R., additional, Luedtke, Alex, additional, Kennedy, Chris J., additional, Cipriani, Andrea, additional, Furukawa, Toshiaki A., additional, and Kessler, Ronald C., additional

Published
2022
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48. Optimization of smartphone psychotherapy for depression and anxiety among patients with cancer using the multiphase optimization strategy (MOST) framework and decentralized clinical trial system (SMartphone Intervention to LEssen depression/Anxiety and GAIN resilience: SMILE AGAIN project): A protocol for a randomized controlled trial

Author

Uchida, Megumi, primary, Furukawa, Toshiaki A, additional, Yamaguchi, Takuhiro, additional, Imai, Fuminobu, additional, Momino, Kanae, additional, Katsuki, Fujika, additional, Sakurai, Naomi, additional, Miyaji, Tempei, additional, Horikoshi, Masaru, additional, Iwata, Hiroji, additional, Zenda, Sadamoto, additional, Iwatani, Tsuguo, additional, Ogawa, Asao, additional, Inoue, Akira, additional, Abe, Masakazu, additional, Toyama, Tatsuya, additional, Uchitomi, Yosuke, additional, Matsuoka, Hiromichi Matsuoka;, additional, Noma, Hisashi, additional, and Akechi, Tatsuo, additional

Published
2022
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