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323 results on '"Furuhama, Kazuhisa"'

26. Radioactive Contamination of a Pig Raised at a Farm within 20 km of the Fukushima Daiichi Nuclear Power Plant

Author

Yamada, Kazutaka, Yamaguchi, Toshiro, Sawano, Kaita, Kishimoto, Miori, and Furuhama, Kazuhisa

Subjects
pig, food safety, pork, caesium, Fukushima, radioactive contamination
Abstract

application/pdf, 福島第一原子力発電所から20km圏内で飼育されていた交雑種豚が，事故17日後に清浄区域へ移動し，移動41日後に試料が採材された。Ge半導体検出器を用いて，バラ，モモ，ロース及び心臓のγ線スペクトルを測定したところ，放射性セシウムの存在が確認された。被検豚は移動前後ともに豚舎で飼育され，生涯汚染のない輸入飼料で飼養されていた。牛肉の放射能汚染の原因は汚染された稲藁と報道されているが，稲藁だけが汚染の原因ではない可能性がある。次世代のために，食の安全の観点から牛肉のみならず他の畜産物についても監視が必要である。

Published
2012

27. Possible role of cysteine-S-conjugate β-lyase in species differences in cisplatin nephrotoxicity

Author

Katayama, Rieko, Nagata, Saori, Iida, Hiroko, Yamagishi, Norio, Yamashita, Tetsuro, and Furuhama, Kazuhisa

Subjects
Species difference, Cisplatin, Nephrotoxicity, Cysteine-S-conjugate β-lyase, Platinum
Abstract

To better understand species differences in cisplatin nephrotoxicity, we focused on renal cysteine-S-conjugate β-lyase (C-S lyase), which may play a crucial role in the metabolism of platinum (Pt)-cysteine conjugates. Aminooxyacetic acid hemihydrochloride (AOAA), an inhibitor of C-S lyase, reduced renal injuries due to cisplatin in rats, suggesting involvement of C-S lyase. On day 5 following a bolus cisplatin injection, three species showed in vivo nephrotoxic potentials in the order of rats > mice = rabbits (the highest to lowest), based on body surface. The levels of renal Pt residue at the nephrotoxic dose were in order of rabbits > rats > mice. Meanwhile, the activity of endogenous (basal) mitochondrial aspartate aminotransferase (AST), one of the C-S lyases, in the renal cortex of naive animals was rats > mice = rabbits. In a qualitative Western blot analysis, expression of mitochondrial C-S lyase in the kidney was observed at approximately 37 kDa in all five species used. In in vitro studies, the cytotoxicity of cisplatin was dependent on the expression level of C-S lyase mRNA in the respective renal cells. These results demonstrate that species differences in cisplatin nephrotoxicity are attributable to an interaction of renal Pt transition with C-S lyase activity.

Published
2011

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