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3. Results from the European Union MAPEC_LIFE cohort study on air pollution and chromosomal damage in children: are public health policies sufficiently protective?

Author

Ceretti, E., Donato, F., Zani, C., Villarini, M., Verani, M., De Donno, A., Bonetta, S., Feretti, D., Carducci, A., Idolo, A., Carraro, E., Covolo, L., Moretti, M., Palomba, G., Grassi, T., Bonetti, A., Bonizzoni, S., Biggeri, A., Gelatti, U., Festa, A., Viola, G. C. V., Zerbini, I., Fatigoni, C., Levorato, S., Monarca, S., Salvatori, T., Vannini, S., Donzelli, G., Bagordo, F., De Giorgi, M., Guido, M., Panico, A., Serio, F., Tumolo, M. R., Gea, M., Gilli, G., Pignata, C., Schiliro, T., Romanazzi, V., Furia, C., Bruni, B., and Casini, B.

Subjects
medicine.medical_specialty, Buccal swab, Air pollution, 010501 environmental sciences, medicine.disease_cause, 01 natural sciences, 03 medical and health sciences, symbols.namesake, 0302 clinical medicine, Environmental health, Epidemiology, medicine, media_common.cataloged_instance, Air quality policy, 030212 general & internal medicine, Poisson regression, European union, Air pollution exposure, Biomarkers of early effects, Children, Chromosomal damage, Air quality index, 0105 earth and related environmental sciences, media_common, Pollutant, business.industry, Pollution, symbols, business, Cohort study
Abstract

Following publication of the original article [1], the typesetters have missed to add the below listed study group author names in XML in author group section. The study group authors have been added to the author group and are presented correctly in this correction article. A minor change has been made to the electronic supplementary files by removing the yellow highlights and included in this correction. Study Group Authors: Andrea Festa1 Gaia Claudia Viviana Viola1 Ilaria Zerbini1 Cristina Fatigoni2 Sara Levorato2 Silvano Monarca2 Tania Salvatori2 Samuele Vannini2 Gabriele Donzelli3 Francesco Bagordo4 Mattia De Giorgi4 Marcello Guido4 Alessandra Panico4 Francesca Serio4 Maria Rosaria Tumolo4 Silvia Bonetta5 Marta Gea5 Giorgio Gilli5 Cristina Pignata5 Tiziana Schilirò5 Valeria Romanazzi5 Camilla Furia6 Beatrice Bruni7 Beatrice Casini7 Study Group Author Affiliations: 1Department of Medical and Surgical Specialties, Radiological Science and Public Health, University of Brescia, 11 Viale Europa, 25123 Brescia, Italy 2Department of Pharmaceutical Sciences, Unit of Public Health, University of Perugia, Via del Giochetto, 06122 Perugia, Italy 3Department of Biology, University of Pisa, 35/39 Via S. Zeno, 56127 Pisa, Italy 4Department of Biological and Environmental Science and Technology, University of Salento, 165 Via Monteroni, 73100 Lecce, Italy 5Department of Public Health and Pediatrics, University of Torino, 94 Piazza Polonia, 10126 Turin, Italy 6Brescia Municipality, 1 Piazza Repubblica, 25100 Brescia, Italy 7Department of Translational Research, N.T.M.S., University of Pisa, 35/39 Via S. Zeno, 56127 Pisa, Italy Author details 1 Department of Medical and Surgical Specialties, Radiological Science and Public Health, University of Brescia, 11 Viale Europa, 25123 Brescia, Italy. 2 Department of Pharmaceutical Sciences, Unit of Public Health, University of Perugia, Via del Giochetto, 06122 Perugia, Italy. 3 Department of Biology, University of Pisa, 35/39 Via S. Zeno, 56127 Pisa, Italy. 4 Department of Biological and Environmental Science and Technology, University of Salento, 165 Via Monteroni, 73100 Lecce, Italy. 5 Department of Public Health and Pediatrics, University of Torino, 94 Piazza Polonia, 10126 Turin, Italy. 6 Multi-sector and Technological Service Centre - CSMT Gestione S.c.a.r.l, 45 Via Branze, 25123 Brescia, Italy. 7 Brescia Municipality, 1 Piazza Repubblica, 25100 Brescia, Italy. 8 Department of Statistic, Computer Science, Applications, University of Florence, 59 Viale Morgagni, 50134 Florence, Italy.

Published
2020

4. Correction to: Results from the European Union MAPEC_LIFE cohort study on air pollution and chromosomal damage in children: are public health policies sufficiently protective? (Environmental Sciences Europe, (2020), 32, 1, (74), 10.1186/s12302-020-00352-3)

Author

Ceretti, E., Donato, F., Zani, C., Villarini, M., Verani, M., De Donno, A., Bonetta, S., Feretti, D., Carducci, A., Idolo, A., Carraro, E., Covolo, L., Moretti, M., Palomba, G., Grassi, T., Bonetti, A., Bonizzoni, S., Biggeri, A., Gelatti, U., Festa, A., Viola, G. C. V., Zerbini, I., Fatigoni, C., Levorato, S., Monarca, S., Salvatori, T., Vannini, S., Donzelli, G., Bagordo, F., De Giorgi, M., Guido, M., Panico, A., Serio, F., Tumolo, M. R., Gea, M., Gilli, G., Pignata, C., Schiliro, T., Romanazzi, V., Furia, C., Bruni, B., and Casini, B.

Subjects
air pollution, chromosomal damage, public health policies, air pollution, public health policies, chromosomal damage
Published
2020

6. Mutagenic and genotoxic effects induced by PM0.5 of different Italian towns in human cells and bacteria: The MAPEC_LIFE study

Author

Bonetta, Sara, primary, Bonetta, Silvia, additional, Schilirò, Tiziana, additional, Ceretti, Elisabetta, additional, Feretti, Donatella, additional, Covolo, Loredana, additional, Vannini, Samuele, additional, Villarini, Milena, additional, Moretti, Massimo, additional, Verani, Marco, additional, Carducci, Annalaura, additional, Bagordo, Francesco, additional, De Donno, Antonella, additional, Bonizzoni, Silvia, additional, Bonetti, Alberto, additional, Pignata, Cristina, additional, Carraro, Elisabetta, additional, Gelatti, Umberto, additional, Gilli, G., additional, Romanazzi, V., additional, Gea, M., additional, Festa, A., additional, Viola, G.C.V., additional, Zani, C., additional, Zerbini, I., additional, Donato, F., additional, Monarca, S., additional, Fatigoni, C., additional, Levorato, S., additional, Salvatori, T., additional, Donzelli, G., additional, Palomba, G., additional, Casini, B., additional, De Giorgi, M., additional, Devoti, G., additional, Grassi, T., additional, Idolo, A., additional, Panico, A., additional, Serio, F., additional, Furia, C., additional, and Colombi, P., additional

Published
2019
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7. Are 6-8 year old Italian children moving away from the Mediterranean diet?

Author

Zani, Claudia, Ceretti, Elisabetta, Grioni, S., Viola, Gaia Claudia Viviana, Donato, Francesco, Feretti, Donatella, Festa, Andrea, Bonizzoni, S., Bonetti, A., Monarca, S., Villarini, M., Levorato, S., Carducci, A., Verani, M., Casini, B., De Donno, A., Grassi, T., Bagordo, F., Carraro, E., Bonetta, S. i., Bonetta, S. a., Gelatti, Umberto, Covolo, Loredana, Levaggi, Rosella, Limina, Rosa Maria, Mazzoleni, Giovanna, Zerbini, Ilaria, Furia, C., Colombi, P., Braga, F., Fatigoni, C., Moretti, M., Vannini, S., Bruni, B., Caponi, E., Donzelli, G., Idolo, A., Guido, M., Devoti, G., Tumolo, M. R., Serio, F., Romanazzi, V., Pignata, C., Schilirò, T., Gilli, G., Zani, C, Ceretti, E, Grioni, S, Viola, G. C. V, Donato, F, Feretti, D, Festa, A, Bonizzoni, S, Bonetti, A, Monarca, S, Villarini, M, Levorato, S, Carducci, A, Verani, M, Casini, B, DE DONNO, Maria Antonella, Grassi, Tiziana, Bagordo, Francesco, Carraro, E, Bonetta, Si, Bonetta, Sa, Gelatti, U, Covolo, L., Levaggi, R., Limina, R. M., Mazzoleni, G., Zerbini, I., Furia, C., Colombi, P., Braga, F., Fatigoni, C., Moretti, M., Vannini, S., Bruni, B., Caponi, E., Donzelli, G., Idolo, Adele, Guido, Marcello, Devoti, G., Tumolo, M. R., Serio, Francesca, Romanazzi, V., Pignata, C., Schilirò, T., and Gilli, G.

Subjects
Medicine (all), Mediterranean diet, Food-frequency questionnaire, Italian mediterranean index, Food-frequency questionnaire, Mediterranean diet, Italian Mediterranean Index, Italian Mediterranean Index
Abstract

The Mediterranean diet (MD) is considered one of the healthiest dietary models, as it decreases the risk of chronic diseases and may modulate the organism's early response to environmental pollution. In recent decades, Mediterranean countries have been replacing their traditional diet with other less healthy eating habits, especially among children and teenagers.

Published
2016

8. Feasibility and reliability of a questionnaire for evaluation of the exposure to indoor and outdoor air pollutants, diet and physical activity in 6-8-year-old children

Author

Zani, C, Donato, F, Grioni, S, Viola, G. C. V, Ceretti, E, Feretti, D, Festa, A, Bonizzoni, S, Bonetti, A, Monarca, S, Villarini, M, Levorato, S, Carducci, A, Verani, M, Casini, B, Carraro, E, Gilli, G, Bonetta, S, Gelatti, U, Covolo, L, Levaggi, R, Limina, RM, Mazzoleni, G, Zerbini, I, Furia, C, Marrese, MR, Colombi, P, Mario, E, Braga, F, Fatigoni, C, Moretti, M, Vannini, S, Bruni, B, Caponi, E, Donzelli, G, Tumolo, MR, Romanazzi, V, Pignata, C, Schilirò T., DE DONNO, Maria Antonella, GRASSI, Tiziana, IDOLO, ADELE, BAGORDO, Francesco, GUIDO, Marcello, DEVOTI, Gabriele, SERIO, FRANCESCA, Zani, C, Donato, F, Grioni, S, Viola, G. C. V, Ceretti, E, Feretti, D, Festa, A, Bonizzoni, S, Bonetti, A, Monarca, S, Villarini, M, Levorato, S, Carducci, A, Verani, M, Casini, B, DE DONNO, Maria Antonella, Grassi, Tiziana, Idolo, Adele, Carraro, E, Gilli, G, Bonetta, S, Gelatti, U, Covolo, L, Levaggi, R, Limina, Rm, Mazzoleni, G, Zerbini, I, Furia, C, Marrese, Mr, Colombi, P, Mario, E, Braga, F, Fatigoni, C, Moretti, M, Vannini, S, Bruni, B, Caponi, E, Donzelli, G, Bagordo, Francesco, Guido, Marcello, Devoti, Gabriele, Tumolo, Mr, Serio, Francesca, Romanazzi, V, Pignata, C, and Schilirò, T.

Subjects
Male, Reproducibility of Result, Environmental Exposure, Health Survey, Motor Activity, Reliability, Food-frequency questionnaire, Diet, Health Statu, Feasibility Studie, Italy, Parent, Air Pollution, Indoor, Surveys and Questionnaires, Female, Repeatability, Child, Children, Environmental Monitoring, Human
Abstract

The MAPEC-Life project aims to study the biological effects of early exposure to air pollutants on the oral mucosa cells of school-age children in five Italian cities. A questionnaire was created to evaluate the association between outdoor and indoor airborne pollutants, lifestyle, diet and biomarker effects. The feasibility and reliability of the questionnaire were evaluated.

Published
2015

9. monitoring air pollution effects on children for supporting public health policy: the protocol of the prospective cohort MAPEC study

Author

Feretti, D., Ceretti, E., Moretti, M., Carducci, A., Bonetta, S., Marrese, M. R., Bonetti, A., Covolo, L., Villarini, M., Verani, M., Schilirò, T., Limina, R. M., Monarca, S., Casini, B., Carraro, E., Zani, C., Mazzoleni, G., Levaggi, R., Gelatti, U., Compiani, S., Donato, F., Festa, A., Viola, G. C. V., Zerbini, I., Idolo, A., Serio, F., Tumolo, M. R., Dominici, L., Fatigoni, C., Levorato, S., Peverini, M., Vannini, S., Bruni, B., Caponi, E., Donzelli, G., Gilli, G., Pignata, C., Bonizzoni, S., Furia, C., Braga, F., Codenotti, R., Colombi, P., Lini, D., Mario, E., DE DONNO, Maria Antonella, BAGORDO, Francesco, GRASSI, Tiziana, GUIDO, Marcello, VERRI, Tiziano, Feretti, D., Ceretti, E., DE DONNO, Maria Antonella, Moretti, M., Carducci, A., Bonetta, S., Marrese, M. R., Bonetti, A., Covolo, L., Bagordo, Francesco, Villarini, M., Verani, M., Schilirò, T., Limina, R. M., Grassi, Tiziana, Monarca, S., Casini, B., Carraro, E., Zani, C., Mazzoleni, G., Levaggi, R., Gelatti, U., Compiani, S., Donato, F., Festa, A., Viola, G. C. V., Zerbini, I., Guido, Marcello, Idolo, A., Serio, F., Tumolo, M. R., Verri, Tiziano, Dominici, L., Fatigoni, C., Levorato, S., Peverini, M., Vannini, S., Bruni, B., Caponi, E., Donzelli, G., Gilli, G., Pignata, C., Bonizzoni, S., Furia, C., Braga, F., Codenotti, R., Colombi, P., Lini, D., Mario, E., Feretti, D, Ceretti, E, Moretti, M, Carducci, A, Bonetta, S, Marrese, M. R, Bonetti, A, Covolo, L, Villarini, M, Verani, M, Schilirò, T, Limina, R. M, Monarca, S, Casini, B, Carraro, E, Zani, C, Mazzoleni, G, and Levaggi, R

Subjects
COMET ASSAY, air pollution, Air pollution, SALMONELLA MUTAGENICITY, environmental pollution, Public health, child health, Mutagenesis, mucosa buccal cell, medicine.disease_cause, MICRONUCLEUS FREQUENCY, Epidemiology, Environmental monitoring, Protocol, Prospective Studies, Child, ENVIRONMENTAL-POLLUTANTS, Health Policy, Absolute risk reduction, General Medicine, PERIPHERAL-BLOOD LYMPHOCYTES, Public Health, mucosa buccal cells, Human, Environmental Monitoring, medicine.medical_specialty, EUROPEAN COHORTS, AMBIENT AIR, DNA damage, PUBLIC HEALTH, children, early biological effect, Air Pollution, Humans, Medicine (all), Environmental health, medicine, EXPOSURE, Socioeconomic status, Health policy, Pollutant, GENETIC-DAMAGE, business.industry, IN-VITRO, Prospective Studie, business
Abstract

Introduction Genotoxic biomarkers have been studied largely in adult population, but few studies so far have investigated them in children exposed to air pollution. Children are a high-risk group as regards the health effects of air pollution and some studies suggest that early exposure during childhood can play an important role in the development of chronic diseases in adulthood. The objective of the project is to evaluate the associations between the concentration of urban air pollutants and biomarkers of early biological effect in children, and to propose a model for estimating the global risk of early biological effects due to air pollutants and other factors in children. Methods and analysis Two biomarkers of early biological effects, DNA damage by the comet assay and the micronuclei (MN) test, will be investigated in oral mucosa cells of 6–8-year-old children. Concurrently, some toxic airborne pollutants (polycyclic aromatic hydrocarbon (PAH) and nitro-PAH) and in vitro air mutagenicity and toxicity in ultra-fine air particulates (PM0.5) will be evaluated. Furthermore, demographic and socioeconomic variables, other sources of exposures to air pollutants and lifestyle variables will be assessed by a structured questionnaire. The associations between sociodemographic, environmental and other exposure variables and biomarkers of early biological effect using univariate and multivariate models will be analysed. A tentative model for calculating the global absolute risk of having early biological effects caused by air pollution and other variables will be proposed. Ethics and dissemination The project has been approved by the Ethics Committees of the local Health Authorities. The results will be communicated to local Public Health Agencies, for supporting educational programmes and health policy strategies. LIFE+2012 Environment Policy and Governance. LIFE12 ENV/IT/000614.

Published
2014

10. Exposure to air pollution and lifestyles of children partecipating in the MAPEC_LIFE (Monitoring Air Pollution Effects on Children for Supporting Public Health Policy) study

Author

Grassi, T, DONNO A, De, Bagordo, F, Ceretti, E, Zani, C, Moretti, M, Levorato, S, Carducci, A, Verani, M, Bonetta, S, Bonizzoni, S, Bonetti, A, Guido, M, Devoti, G, Gelatti, U, Bruni, B, Carraro, E, Casini, B, Codenotti, R, Colombi, T, Covolo, L, Crottini, S, De Giorgi, M, Donato, F, Donzelli, G, Fatigoni, C, Feretti, D, Festa, A, Furia, C, Gaffurini, L, Gilli, G, Idolo, A, Limina, Rm, Monarca, S, Pignata, C, Romanazzi, V, Salvatori, T, Schilirò, T, Serio, F, Vannini, S, Verri, T, Villarini, M, Viola, Gcv, Zagni, L, and Zerbini, I

Published
2016

11. The MAPEC_LIFE Study: indoor/outdoor air pollution exposure and lifestyles of the prospective cohort

Author

DONNO A, De, Bagordo, F, Zani, C, Ceretti, E, Villarini, M, Vannini, S, Carducci, A, Casini, B, Bonetta, S, Schilirò, T, Bonizzoni, S, Bonetti, A, Grassi, T, Guido, M, Devoti, G, Gelatti, U, Serio, F., Idolo, A., De Giorgi, M., Tumolo, M. R., Verri, T., Covolo, L., Donato, F., Feretti, D., Festa, A., Limina, R. M., Viola, G. C., Zerbini, I., Fatigoni, C., Levorato, S., Monarca, S., Moretti, M., Salvatori, T., Donzelli, G., Verani, M., Bruni, B., Bonetta, Si., Carraro, E., Gilli, G., Pignata, C., Romanazzi, V., Furia, C., Codenotti, R., Colombi, P., Crottini, S., Gaffurini, L., and Zagni, L.

Published
2016

12. Monitoring air pollution effects in children for supporting public health policy: the MAPEC_LIFE study

Author

Ceretti, Elisabetta, Bonizzoni, S, Bonetti, A, Monarca, S, Carducci, A, DONNO MA, De, Carraro, E, Gelatti, Umberto, MAPEC_LIFE STUDY GROUP, The, Covolo, Loredana, Donato, Francesco, Feretti, Donatella, Festa, Andrea, Limina, Rosa Maria, Viola, Gaia Claudia Viviana, Zani, Claudia, Zerbini, Ilaria, Levaggi, Rosella, Mazzoleni, Giovanna, and Furia, C.

Subjects
Environmental health
Published
2014

13. The MAPEC_LIFE study (LIFE12 ENV/IT/000614): monitoring air pollution effects in children for supporting public health policy

Author

MARCO VERANI, annalaura carducci, BEATRICE CASINI, Marrese, M. R., Bonetti, A., Monarca, S., Donno, M. A., Carraro, E., Gelatti, U., Caponi, Elisa, Donzelli, Gabriele, Bruni, Beatrice, Ceretti, E., Covolo, L., Donato, F., Feretti, D., Festa, A., Limina, R. M., Viola, G. C. V., Zani, C., Zerbini, I., Levaggi, R., Mazzoleni, G., Bonizzoni, S., Furia, C., Codenotti, R., Colombi, P., Crottini, S., Mario, E., Dominici, L., Fatigoni, C., Levorato, S., Moretti, M., Vannini, S., Villarini, M., Bagordo, F., Grassi, T., Guido, M., and Idolo, A.

Published
2014

22. Monitoraggio degli effetti dell’inquinamento atmosferico sui bambini a sostegno delle strategie di sanità pubblica: il progetto MAPEC_LIFE

Author

Donato, F., Bonizzoni, S., Bonetti, A., Monarca, S., annalaura carducci, Donno, M. A., Carraro, E., Gelatti, U., Ceretti, E., Covolo, L., Feretti, D., Festa, A., Levaggi, R., Limina, R. M., Mazzoleni, G., Viola, G. C. V., Zani, C., Zerbini, I., Furia, C., Marrese, M. R., Codenotti, R., Colombi, P., Crottini, S., Mario, E., Dominici, L., Fatigoni, C., Levorato, S., Moretti, M., Vannini, S., Villarini, M., Bruni, B., Caponi, Elisa, BEATRICE CASINI, MARCO VERANI, Bagordo, F., Grassi, T., Guido, M., Idolo, A., Verri, T., Bonetta, S., Gilli, G., Pignata, C., and Schilirò, T.

23. The MAPEC LIFE study: monitoring air pollution effects in children for supporting public health policy

Author

Ceretti, E., Marrese, M. R., Bonetti, A., Monarca, S., annalaura carducci, Donno, M. A., Carraro, E., Gelatti, U., Covolo, L., Donato, F., Feretti, D., Festa, A., Limina, R. M., Viola, G. C. V., Zani, C., Zerbini, I., Bonizzoni, S., Furia, C., Codenotti, R., Colombi, P., Crottini, S., Mario, E., Dominici, L., Fatigoni, C., Villarini, M., Caponi, Elisa, BEATRICE CASINI, MARCO VERANI, Bagordo, F., Grassi, T., Guido, M., Idolo, A., Bonetta, S., Gilli, G., Pignata, C., and Schilirò, T.

25. Mutagenic and genotoxic effects induced by PM0.5 of different Italian towns in human cells and bacteria: The MAPEC_LIFE study

Author

Bonetta, Sara, Bonetta, Silvia, Schiliro', Tiziana, Elisabetta, Ceretti, Donatella, Feretti, Loredana, Covolo, Samuele, Vannini, Milena, Villarini, Massimo, Moretti, Marco, Verani, Annalaura, Carducci, Francesco, Bagordo, Antonella De Donno, Silvia, Bonizzoni, Alberto, Bonetti, Pignata, Cristina, Carraro, Elisabetta, Umberto, Gelatti, MAPEC_LIFE Study Group, Gilli, G., Romanazzi, V., Gea, M., Festa, A., Viola, G. C. V., Zani, C., Zerbini, I., Donato, F., Monarca, S., Fatigoni, C., Levorato, S., Salvatori, T., Donzelli, G., Palomba, G., Casini, B., Giorgi, De, Devoti, M., Grassi, G., Idolo, T., Panico, A., Serio, A., Furia, F., Colombi, C., Bonetta, Sara, Bonetta, Silvia, Schilirò, Tiziana, Ceretti, Elisabetta, Feretti, Donatella, Covolo, Loredana, Vannini, Samuele, Villarini, Milena, Moretti, Massimo, Verani, Marco, Carducci, Annalaura, Bagordo, Francesco, De Donno, Antonella, Bonizzoni, Silvia, Bonetti, Alberto, Pignata, Cristina, Carraro, Elisabetta, Gelatti, Umberto, Gilli, G., Romanazzi, V., Gea, M., Festa, A., Viola, G. C. V., Zani, C., Zerbini, I., Donato, F., Monarca, S., Fatigoni, C., Levorato, Maria Chiara, Salvatori, T., Donzelli, G., Palomba, G., Casini, B., De Giorgi, M., Devoti, G., Grassi, T., Idolo, A., Panico, A., Serio, F., Furia, C., and Colombi, P.

Subjects
Veterinary medicine, Genotoxicity, Mutagenicity, Nitro-PAHs, PAHs, PM0.5, Toxicology, Pollution, Health, Toxicology and Mutagenesis, 010504 meteorology & atmospheric sciences, PM, 010501 environmental sciences, medicine.disease_cause, 01 natural sciences, Ames test, nitro-PAHs, Salmonella, Bioassay, Polycyclic Aromatic Hydrocarbon, Child, media_common, General Medicine, Particulates, Citie, Italy, Air Pollutant, Health, PM0.5, mutagenicity, genotoxicity,comet assy, PAHs, nitro-PAHs, comet assy, Human, Nitro-PAH, media_common.quotation_subject, Biology, medicine, Toxicology and Mutagenesis, Particle Size, A549 Cell, 0105 earth and related environmental sciences, Pollutant, Epithelial Cell, genotoxicity, mutagenicity, PAH, 0.5, biology.organism_classification, Comet assay, Mutagenicity Test, Particulate Matter, Season, Bacteria, DNA Damage
Abstract

Particulate matter (PM) is considered an atmospheric pollutant that mostly affects human health. The finest fractions of PM (PM2.5 or less) play a major role in causing chronic diseases. The aim of this study was to investigate the genotoxic effects of PM0.5 collected in five Italian towns using different bioassays. The role of chemical composition on the genotoxicity induced was also evaluated. The present study was included in the multicentre MAPEC_LIFE project, which aimed to evaluate the associations between air pollution exposure and early biological effects in Italian children. PM10 samples were collected in 2 seasons (winter and spring) using a high-volume multistage cascade impactor. The results showed that PM0.5 represents a very high proportion of PM10 (range 10–63%). PM0.5 organic extracts were chemically analysed (PAHs, nitro-PAHs) and tested by the comet assay (A549 and BEAS-2B cells), MN test (A549 cells) and Ames test on Salmonella strains (TA100, TA98, TA98NR and YG1021). The highest concentrations of PAHs and nitro-PAHs in PM0.5 were observed in the Torino, Brescia and Pisa samples in winter. The Ames test showed low mutagenic activity. The highest net revertants/m3 were observed in the Torino and Brescia samples (winter), and the mutagenic effect was associated with PM0.5 (p < 0.01), PAH and nitro-PAH (p < 0.05) concentrations. The YG1021 strain showed the highest sensitivity to PM0.5 samples. No genotoxic effect of PM0.5 extracts was observed using A549 cells except for some samples in winter (comet assay), while BEAS-2B cells showed light DNA damage in the Torino, Brescia and Pisa samples in winter, highlighting the higher sensitivity of BEAS-2B cells, which was consistent with the Ames test (p < 0.01). The results obtained showed that it is important to further investigate the finest fractions of PM, which represent a relevant percentage of PM10, taking into account the chemical composition and the biological effects induced. Results highlighted the importance to further investigate the finest fractions of PM, which represent a relevant percentage of PM10, taking into account its chemical composition and the biological effects induced.

Published
2019

26. Buccal micronucleus cytome assay in primary school children: A descriptive analysis of the MAPEC_LIFE multicenter cohort study

Author

Andrea Festa, Milena Villarini, Roberta Codenotti, Francesco Donato, G. Palomba, Gabriele Donzelli, Camilla Furia, Donatella Feretti, Sara Levorato, Samuele Vannini, S. Bonizzoni, Marcello Guido, Licia Zagni, Valeria Romanazzi, Umberto Gelatti, Silvia Bonetta, Annalaura Carducci, Massimo Moretti, Tania Salvatori, Tiziana Schilirò, Loredana Covolo, Gaia Claudia Viviana Viola, Paolo Colombi, Elisabetta Carraro, Claudia Zani, Francesco Bagordo, A. Bonetti, Elisabetta Ceretti, Adele Idolo, Silvano Monarca, Mattia De Giorgi, Marta Gea, Giorgio Gilli, Cristina Pignata, Francesca Di Serio, Antonella De Donno, Tiziana Grassi, Cristina Fatigoni, Marco Verani, Tiziano Verri, Sara Bonetta, Alessandra Panico, Ilaria Zerbini, Villarini, M., Levorato, S., Salvatori, T., Ceretti, E., Bonetta, S., Carducci, A., Grassi, T., Vannini, S., Donato, F., Verani, M., De Donno, A., Bonizzoni, S., Bonetti, A., Moretti, M., Gelatti, U., Fatigoni, C., Monarca, S., Covolo, L., Feretti, D., Festa, A., Viola, Gcv., Zani, C., Zerbini, I., Gilli, G., Carraro, E., Schilirò, T., Pignata, C., Gea, M., Romanazzi, V., Donzelli, G., Palomba, G., Bagordo, F., De Giorgi, M., Guido, M., Idolo, A., Panico, A., Serio, F., Verri, T., Furia, C., Colombi, P., Codenotti, R., and Zagni, L.

Subjects
0301 basic medicine, Male, Buccal micronucleus cytome assay, Buccal swab, Air pollution, Buccal micronucleus cytome assay, Children, Early biological effects, MAPEC_LIFE study, Socio-economic factors, Public Health, Environmental and Occupational Health, MAPEC_LIFE study, Early biological effects, Cohort Studies, 03 medical and health sciences, Air Pollution, Medicine, Humans, Child, Children, Air pollution, Socio-economic factors, Public Health, Environmental and Occupational Health, Micronucleus Tests, Schools, business.industry, Environmental and Occupational Health, Mouth Mucosa, Buccal administration, Environmental Exposure, 030104 developmental biology, Italy, Micronucleus test, Cohort, Female, Public Health, Seasons, Winter season, Micronucleus, business, Life study, Children, Air pollution, Socio-economic factors, Early biological effects, Buccal micronucleus cytome assay, MAPEC_LIFE study, Demography, Cohort study
Abstract

Background Recent data support the hypothesis that genetic damage occurring early in life during childhood can play an important role in the development of chronic diseases in adulthood, including cancer. Objectives The objective of this paper, part of the MAPEC_LIFE project, is to describe the frequency of micronuclei and meta-nuclear alterations in exfoliated buccal cells of 6–8year-old Italian children recruited in five Italian towns (i.e., Brescia, Torino, Pisa, Perugia and Lecce) with different air pollution levels. Methods About 200 children per town were recruited from primary schools. Biological samples were collected twice from the same children, in two different seasons (winter 2014-15 and late spring 2015). Cytogenetic damage was evaluated by the buccal micronucleus cytome assay. Results Overall,n = 1046 children represent the final cohort of the MAPEC_LIFE study. On the whole, the results showed a higher mean MN frequency in winter (0.42 ± 0.54‰) than late-spring (0.22 ± 0.34‰). MN frequency observed among the five Italian towns showed a trend that follows broadly the levels of air pollution in Italy: the highest MN frequency was observed in Brescia during both seasons, the lowest in Lecce (winter) and Perugia (late-spring). Conclusions To the best of our knowledge, the number of recruited children included in the analysis (n = 1046) is the highest compared to previous studies evaluating the frequency of MN in exfoliated buccal cells so far. MN frequency was associated with winter season and living in towns at various levels of air pollution, suggesting an important role of this exposure in determining early cytogenetic effects.

Published
2018

27. Air pollution biological effects in children living in Lecce (Italy) by Buccal micronucleus cytome assay (the MAPEC_LIFE study)

Author

Rosa Maria Limina, Tania Salvatori, Gianpaolo Donzelli, Elisabetta Carraro, Cristina Fatigoni, Tiziana Schilirò, Cristina Pignata, Claudia Zani, L. Gaffurini, Silvano Monarca, Annalaura Carducci, Milena Villarini, Marco Verani, Valeria Romanazzi, Francesca Di Serio, Tiziano Verri, Samuele Vannini, Beatrice Casini, Si. Bonetta, G. Devoti, Francesco Bagordo, C. Furia, S. Crottini, A. Bonetti, Adele Idolo, M. De Giorgi, Sara Bonetta, Gaia Claudia Viviana Viola, Elisabetta Ceretti, Maria Rosaria Tumolo, Francesco Donato, S. Bonizzoni, Donatella Feretti, Beatrice Bruni, Marcello Guido, Andrea Festa, A. De Donno, Tiziana Grassi, Loredana Covolo, Umberto Gelatti, R. Codenotti, Ilaria Zerbini, Licia Zagni, Massimo Moretti, Giorgio Gilli, P. Colombi, S. Levorato, DE DONNO, Maria Antonella, Grassi, Tiziana, Ceretti, E., Viola, G. C. V., Levorato, S., Vannini, S., Salvatori, T., Carducci, A., Verani, M., Bonetta, S. A., Carraro, E., Bonizzoni, S., Bonetti, A., Bagordo, Francesco, Serio, Francesca, Idolo, Adele, Gelatti, U., Bonetta, S. i., Bruni, B., Casini, B., Codenotti, R., Colombi, P., Covolo, L., Crottini, S., De Giorgi, M., Devoti, G., Donato, F., Donzelli, G., Fatigoni, C., Feretti, D., Festa, A., Furia, C., Gaffurini, L., Gilli, G., Guido, Marcello, Limina, R. M., Monarca, S., Moretti, M., Pignata, C., Romanazzi, V., Schilirò, T., Tumolo, M. R., Verri, Tiziano, Villarini, M., Zagni, L., Zani, C., and Zerbini, I.

Subjects
0301 basic medicine, Monitoring, Geography, Planning and Development, Buccal swab, Air pollution, Early Biological Effects, Management, Monitoring, Policy and Law, MAPEC_LIFE study, medicine.disease_cause, Buccal mucosa, 03 medical and health sciences, Air pollutants, Environmental protection, Environmental health, Air Pollution, medicine, Renewable Energy, Children, Public health policy, Planning and Development, Geography, Sustainability and the Environment, Policy and Law, Renewable Energy, Sustainability and the Environment, business.industry, MAPEC-LIFE Study, Micronucleus Cytome Assay, Buccal administration, Management, 030104 developmental biology, Micronucleus test, Micronucleus, business, air pollution, children, early biological effects, MAPEC_LIFE study, micronucleus cytome assay
Abstract

The aim of the MAPEC_LIFE (Monitoring Air Pollution Effects on Children for Supporting Public Health Policy) study is to evaluate the associations between the concentrations of air pollutants and early biological effects in children living in five Italian towns (Brescia, Torino, Lecce, Perugia and Pisa) characterised by varying levels of air pollution. This paper presents the results of micronucleus cytome assays performed on the oral mucosa cells of subjects living in Lecce (Puglia, Italy) and their relationship to factors associated with indoor/outdoor exposure and lifestyles. The study was conducted on 6-8-year-old schoolchildren living in Lecce. The micronucleus cytome assay was performed on exfoliated buccal cells collected from the oral mucosa of children using a soft-bristled toothbrush. Micronuclei were evaluated only in normal differentiated cells. Overall, 43.0% of the samples tested were positive, with an average frequency of 0.28 MN/1000 differentiated cells. Data analysis shows positive associations between the frequency of MN in the children’s buccal mucosa cells and obesity, heavy traffic and smoking mothers, while outdoor sports seem to have the opposite effect. These data will be integrated with data from the other cities involved in the MAPEC_LIFE study and could be used

Published
2016

28. Prevalence and associated factors of aspiration and severe dysphagia in asymptomatic patients in the late period after open partial laryngectomy: a videofluoroscopic evaluation.

Author

Freitas AS, Santos IC, Furia C, Dornelas R, Silva ACAE, Dias FL, and Salles GF

Subjects
Deglutition, Fluoroscopy, Humans, Laryngectomy adverse effects, Laryngectomy methods, Prevalence, Serum Albumin, Weight Loss, Deglutition Disorders diagnostic imaging, Deglutition Disorders epidemiology
Abstract

Purpose: This study aimed to evaluate late and asymptomatic patients after open partial horizontal laryngectomy (OPHL), investigating the clinical-surgical and socio-demographic factors associated with aspiration and severe dysphagia., Methods: One-thousand videofluoroscopic swallowing studies were performed in 100 asymptomatic patients in the late period after OPHL(median 6.5 years). Aspiration and severe dysphagia were, respectively, assessed by the Penetration-Aspiration scale (PAS) and by the Dynamic Imaging Grade of Swallowing Toxicity (DIGEST) classification. Associated factors were investigated by multivariate logistic regressions., Results: 34% (95% CI 24.3-47.6%) of patients presented aspiration and 23% (95% CI 15.3-34.6%) had severe or life-threatening dysphagia (DIGEST grades 3-4). On logistic regression, the presence of aspiration was associated with lower preoperative serum albumin (odds ratio [OR]: 0.22; 95% CI 0.07-0.64; p = 0.005, for each 1 g/dL increment); a greater weight loss in early postoperative period (OR: 1.19, 95% CI 1.05-1.35; p = 0.008, for each 1 kg loss); older age at surgery (OR: 1.08; 95% CI 1.01-1.17, for each 1-year older); and with the presence of diabetes (OR: 5.16; 95% CI 1.09-27.47; p = 0.039)., Conclusion: Deglutition abnormalities are frequent in asymptomatic patients later after OPHL. Older patients, with lower preoperative serum albumin levels, with greater postoperative weight loss, and with diabetes compose the clinical profile at risk for having worse swallowing function in the late period after OPHL., (© 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)

Published
2022
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29. The Relationship Between Spiritual Life and Quality of Life in People with Intellectual Disability and/or Low-Functioning Autism Spectrum Disorders.

Author

Bertelli MO, Del Furia C, Bonadiman M, Rondini E, Banks R, and Lassi S

Subjects
Humans, Religion, Autism Spectrum Disorder psychology, Intellectual Disability psychology, Quality of Life, Spirituality
Abstract

Spirituality seems to represent a relevant domain in the person-centred care planning and outcome assessment for persons with intellectual disability and low-functioning autism spectrum disorder. Despite this, the impact of spirituality on subjective well-being and quality of life (QoL) has been scarcely investigated. The aim of the present study was to map the international scientific literature in order to identify the reasons of such misconsideration and the key points for future research and practice implementation. The relationship between spirituality and QoL depends on a complexity of factors, ranging from QoL theoretical models to services' organisation. Personal attitude, family members, health and social-care personnel, training, faith and life communities, and even different religions seem to deserve an in-depth analysis.

Published
2020
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30. Stiff Substrates Increase Inflammation-Induced Endothelial Monolayer Tension and Permeability.

Author

Urbano RL, Furia C, Basehore S, and Clyne AM

Subjects
Animals, Biomechanical Phenomena, Endothelial Cells drug effects, Inflammation metabolism, Inflammation pathology, Permeability drug effects, Signal Transduction drug effects, Swine, Thrombin pharmacology, Tumor Necrosis Factor-alpha pharmacology, Vasoconstriction drug effects, rho-Associated Kinases metabolism, Endothelial Cells metabolism, Endothelial Cells pathology, Stress, Mechanical, Vascular Stiffness drug effects
Abstract

Arterial stiffness and inflammation are associated with atherosclerosis, and each have individually been shown to increase endothelial monolayer tension and permeability. The objective of this study was to determine if substrate stiffness enhanced endothelial monolayer tension and permeability in response to inflammatory cytokines. Porcine aortic endothelial cells were cultured at confluence on polyacrylamide gels of varying stiffness and treated with either tumor necrosis factor-α (TNFα) or thrombin. Monolayer tension was measured through vinculin localization at the cell membrane, traction force microscopy, and phosphorylated myosin light chain quantity and actin fiber colocalization. Cell permeability was measured by cell-cell junction confocal microscopy and a dextran permeability assay. When treated with TNFα or thrombin, endothelial monolayers on stiffer substrates showed increased traction forces, vinculin at the cell membrane, and vinculin phosphorylation, suggesting elevated monolayer tension. Interestingly, VE-cadherin shifted toward a smaller molecular weight in endothelial monolayers on softer substrates, which may relate to increased VE-cadherin endocytosis and degradation. Phosphorylated myosin light chain colocalization with actin stress fibers increased in endothelial monolayers treated with TNFα or thrombin on stiffer substrates, indicating elevated cell monolayer contractility. Endothelial monolayers also developed focal adherens intercellular junctions and became more permeable when cultured on stiffer substrates in the presence of the inflammatory cytokines. Whereas each of these effects was likely mitigated by Rho/ROCK, Rho/ROCK pathway inhibition via Y27632 disrupted cell-cell junction morphology, showing that cell contractility is required to maintain adherens junction integrity. These data suggest that stiff substrates change intercellular junction protein localization and degradation, which may counteract the inflammation-induced increase in endothelial monolayer tension and thereby moderate inflammation-induced junction loss and associated endothelial monolayer permeability on stiffer substrates., (Copyright © 2017 Biophysical Society. Published by Elsevier Inc. All rights reserved.)

Published
2017
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31. Speech intelligibility after glossectomy and speech rehabilitation.

Author

Furia CL, Kowalski LP, Latorre MR, Angelis EC, Martins NM, Barros AP, and Ribeiro KC

Subjects
Adult, Aged, Carcinoma, Squamous Cell pathology, Female, Follow-Up Studies, Humans, Male, Middle Aged, Neoplasm Staging, Phonetics, Speech Production Measurement, Tongue Neoplasms pathology, Articulation Disorders rehabilitation, Carcinoma, Squamous Cell surgery, Glossectomy rehabilitation, Postoperative Complications rehabilitation, Speech Intelligibility, Speech Therapy, Tongue Neoplasms surgery
Abstract

Background: Oral tumor resections cause articulation deficiencies, depending on the site, extent of resection, type of reconstruction, and tongue stump mobility., Objectives: To evaluate the speech intelligibility of patients undergoing total, subtotal, or partial glossectomy, before and after speech therapy., Patients and Methods: Twenty-seven patients (24 men and 3 women), aged 34 to 77 years (mean age, 56.5 years), underwent glossectomy. Tumor stages were T1 in 3 patients, T2 in 4, T3 in 8, T4 in 11, and TX in 1; node stages, N0 in 15 patients, N1 in 5, N2a-c in 6, and N3 in 1. No patient had metastases (M0). Patients were divided into 3 groups by extent of tongue resection, ie, total (group 1; n = 6), subtotal (group 2; n = 9), and partial (group 3; n = 12). Different phonological tasks were recorded and analyzed by 3 experienced judges, including sustained 7 oral vowels, vowel in a syllable, and the sequence vowel-consonant-vowel (VCV). The intelligibility of spontaneous speech (sequence story) was scored from 1 to 4 in consensus. All patients underwent a therapeutic program to activate articulatory adaptations, compensations, and maximization of the remaining structures for 3 to 6 months. The tasks were recorded after speech therapy. To compare mean changes, analyses of variance and Wilcoxon tests were used., Results: Patients of groups 1 and 2 significantly improved their speech intelligibility (P<.05). Group 1 improved vowels, VCV, and spontaneous speech; group 2, syllable, VCV, and spontaneous speech. Group 3 demonstrated better intelligibility in the pretherapy phase, but the improvement after therapy was not significant., Conclusions: Speech therapy was effective in improving speech intelligibility of patients undergoing glossectomy, even after major resection. Different pretherapy ability between groups was seen, with improvement of speech intelligibility in groups 1 and 2. The improvement of speech intelligibility in group 3 was not statistically significant, possibly because of the small and heterogeneous sample.

Published
2001

32. Video fluoroscopic evaluation after glossectomy.

Author

Furia CL, Carrara-de Angelis E, Martins NM, Barros AP, Carneiro B, and Kowalski LP

Subjects
Adult, Aged, Aged, 80 and over, Barium Sulfate, Child, Contrast Media, Deglutition Disorders rehabilitation, Female, Humans, Male, Middle Aged, Postoperative Complications rehabilitation, Surgical Flaps, Deglutition Disorders diagnosis, Fluoroscopy, Glossectomy, Postoperative Complications diagnosis, Tongue Neoplasms surgery, Video Recording
Abstract

Background: The swallowing deficits that result from oral or oropharyngeal resections vary considerably depending on the site, extension of the resection, and type of reconstruction. Most patients will experience some degree of dysphagia despite the reconstructive effort. Furthermore, a glossectomy is frequently associated with voice and speech difficulties., Objectives: To characterize swallowing in patients who underwent a glossectomy and to define the limits and the compensatory movements using video fluoroscopic analysis., Design and Setting: Video fluoroscopic evaluation of 15 patients who underwent glossectomies at the Centro de Tratamento e Pesquisa Hospital do Cancer A. C. Camargo, S*ao Paulo, Brazil., Patients: We examined 15 patients: 5 who underwent a partial glossectomy, 2 who underwent a subtotal glossectomy, and 8 who underwent a total glossectomy with laryngeal preservation and reconstruction with myocutaneous flaps (9 pectoralis major flaps and 1 latissimus dorsi flap). The 15 patients were enrolled in a program that included voice, speech, and swallowing rehabilitation., Results: All patients who underwent a partial glossectomy had difficulties with formation and anteroposterior propulsion of the bolus in the oral cavity and an increase in oral transit time, which was more evident with materials of thicker consistencies. All patients who underwent a total or subtotal glossectomy with laryngeal preservation had an increase in oral transit time and stasis of food in the oral cavity, the pharynx, and the superior esophageal sphincter. Of the 15 patients, 2 had moderate and asymptomatic aspiration. These 2 patients had swallowing compensations, such as increased buccal, mandibular, pharyngeal, and laryngeal activity and voluntary protection of the larynx during swallowing., Conclusions: This study demonstrates the effectiveness of swallowing in patients who were enrolled in voice, speech, and swallowing rehabilitation after undergoing a partial or total glossectomy. An increase in oral transit time was detected in all patients. Only 2 of the 10 patients who underwent a total glossectomy had persistent asymptomatic aspiration.

Published
2000
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