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271 results on '"Furano, A V"'

23. Recombination creates novel L1 (LINE-1) elements in Rattus norvegicus

Author

Hayward, Bruce E., Zavanelli, Mary, and Furano, Anthony V.

Subjects
Rattus norvegicus -- Genetic aspects, Gene mutations -- Analysis, Genetic recombination -- Analysis, Transposons -- Analysis, Biological sciences
Abstract

Mammalian L1 (long interspersed repeated DNA, LINE-1) retrotransposons consist of a 5[prime] untranslated region (UTR) with regulatory properties, two protein encoding regions (ORF I, ORF II, which encodes a reverse transcriptase) and a 3[prime] UTR. L1 elements have been evolving in mammals for >100 million years and this process continues to generate novel L1 subfamilies in modern species. Here we characterized the youngest known subfamily in Rattus norvegicus, [L1.sub.mlvi2], and unexpectedly found that this element has a dual ancestry. While its 3[prime] UTR shares the same lineage as its nearest chronologically antecedent subfamilies, [L1.sub.3] and [L1.sub.4], its ORF I sequence does not. The [L1.sub.mlvi2] ORF I was derived from an ancestral ORF I sequence that was the evolutionary precursor of the [L1.sub.3] and [L1.sub.4] ORF I. We suggest that an ancestral ORF I sequence was recruited into the modern [L1.sub.mlvi2] subfamily by recombination that possibly could have resulted from template strand switching by the reverse transcriptase during L1 replication. This mechanism could also account for some of the structural features of rodent L1 5[prime] UTR and ORF I sequences including one of the more dramatic features of L1 evolution in mammals, namely the repeated acquisition of novel 5[prime] UTRs.

Published
1997

35. CpG dinucleotides and the mutation rate of non-CpG DNA

Author

Walser, Jean-Claude, Ponger, Loic, and Furano, Anthony V.

Subjects
Nucleotide sequence -- Analysis, Mutation (Biology) -- Analysis, Nucleotides -- Composition, Retrotransposons -- Analysis, Health
Abstract

The sequence divergences of several different retrotransposon sequences are measured to determine the base substitution rate and the mutation rate of the CpG dinucleotides and non-CpG DNA. The mutation rate of non-CpG DNA is shown to be completely dependent on the varying content of local CpG.

Published
2008

36. The insertional history of an active family of L1 retrotransposons in humans

Author

Boissinot, Stephane, Entezam, Ali, Young, Lynn, Munson, Peter J., and Furano, Anthony V.

Subjects
Human genetics -- Research, Retrotransposons -- Research, Health
Abstract

A non-biased method is used to clone Ta-1 retrotransposon-containing loci from representative of four ethnic populations. 227 distinct Ta-1 loci are obtained and an additional 67 loci in the human genome database are identified.

Published
2004

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