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1,196 results on '"Fundación Mapfre"'

1. Ozone Therapy in Refractory Ischemic Heart Disease. (O3Cardio)

Author: Servicio Canario de Salud, Red de Investigación en Servicios de Salud en Enfermedades Crónicas, Fundación Canaria de Investigación Sanitaria, Colegio Oficial de Médicos de Las Palmas, Fundación MAPFRE Guanarteme, and Bernardino Clavo, MD, PhD, MD, PhD, Head of Research Unit
Published: 2022

2. Prehabilitation in Bariatric Surgery

Author: Fundación MAPFRE Guanarteme and Rosa María Sánchez Hernández, Attending Physician
Published: 2019

3. Effects of vincristine and monosodium glutamate on gastrointestinal motility and visceral sensitivity

Author: Fundación Mapfre, Ministerio de Ciencia e Innovación (España), Comunidad de Madrid, Ministerio de Ciencia, Innovación y Universidades (España), Grupo Español de Motilidad Digestiva, Asociación Española de Gastroenterología, Universidad Rey Juan Carlos, Lopez-Tofiño, Yolanda, de Sosa, F., Vera, Gema, López-Gómez, L., Herradón, Esperanza, López-Miranda, Visitación, Nurgali, K., Uranga, J. A., Abalo, Raquel, Fundación Mapfre, Ministerio de Ciencia e Innovación (España), Comunidad de Madrid, Ministerio de Ciencia, Innovación y Universidades (España), Grupo Español de Motilidad Digestiva, Asociación Española de Gastroenterología, Universidad Rey Juan Carlos, Lopez-Tofiño, Yolanda, de Sosa, F., Vera, Gema, López-Gómez, L., Herradón, Esperanza, López-Miranda, Visitación, Nurgali, K., Uranga, J. A., and Abalo, Raquel
Abstract: Background: Chemotherapy-induced adverse effects are an unresolved nightmare. In preclinical studies in rats, the food additive monosodium glutamate (MSG) improved some of the side effects caused by cisplatin, but its effects in other models of chemotherapy-treated animals are not well known. The aim of this study was to test if MSG may improve some of the adverse effects induced by vincristine in rats. Methods: Young male Wistar rats were exposed or not to MSG (4 g L) in drinking water from week 0 till 1 week after treatment (week 3). Rats received two cycles of five daily intraperitoneal (ip) injections (Monday to Friday, weeks 1 and 2) of either saline (2 mL kg) or vincristine (0.1 mg kg). Gastrointestinal motility was measured in vivo by radiological methods after the first and tenth ip administrations. On week 3, the threshold for mechanical somatic and colorectal sensitivity was recorded using Von Frey filaments applied to the paws and an intracolonic balloon, respectively. Finally, samples of the terminal ileum and distal colon were histologically evaluated in sections. Key Results: Vincristine reduced body weight gain, food intake, and upper gastrointestinal transit, caused somatic (but not visceral) hypersensitivity and increased the thickness of the submucosal and muscle layers of the small intestine. In vincristine-treated animals, MSG partially prevented gastrointestinal dysmotility and reduced visceral sensitivity but did not improve structural alterations of the small intestine. Conclusions & Inferences: MSG could be used as an adjuvant to conventional treatments to improve some gastrointestinal dysfunctions caused by chemotherapy.
Published: 2024

4. Unilateral focused ultrasound subthalamotomy in early Parkinson's disease: a pilot study

Author: Fundación de Investigación HM Hospitales, Fundación Mapfre, Zambon, Sociedad Española de Neurología, Martínez Fernández, Raúl, Natera Villalba, Elena, Rodriguez-Rojas, Rafael, Álamo, Marta del, Pineda-Pardo, José A., Obeso, Ignacio, Mata-Marín, David, Guida, Pasqualina, Jimenez-Castellanos, Tamara, Pérez-Bueno, Diana, Duque, Alicia, Máñez Miró, Jorge U., Gasca-Salas, Carmen, Matarazzo, Michele, Obeso, José A., Fundación de Investigación HM Hospitales, Fundación Mapfre, Zambon, Sociedad Española de Neurología, Martínez Fernández, Raúl, Natera Villalba, Elena, Rodriguez-Rojas, Rafael, Álamo, Marta del, Pineda-Pardo, José A., Obeso, Ignacio, Mata-Marín, David, Guida, Pasqualina, Jimenez-Castellanos, Tamara, Pérez-Bueno, Diana, Duque, Alicia, Máñez Miró, Jorge U., Gasca-Salas, Carmen, Matarazzo, Michele, and Obeso, José A.
Abstract: [Background] Unilateral focused ultrasound subthalamotomy (FUS-STN) improves motor features of Parkinson’s disease (PD) in moderately advanced patients. The less invasive nature of FUS makes its early application in PD feasible. We aim to assess the safety and efficacy of unilateral FUS-STN in patients with PD of less than 5 years from diagnosis (early PD)., [Methods] Prospective, open-label study. Eligible patients with early PD had highly asymmetrical cardinal features. The primary outcome was safety, defined as treatment-related adverse events at 6 months. Secondary outcomes included efficacy, assessed as motor improvement in the Movement Disorders Society-Unified Parkinson’s Disease Rating Scale (MDS-UPDRS), motor fluctuations, non-motor symptoms, daily living activities, quality of life, medication and patients’ impression of change., [Results] Twelve patients with PD (median age 52.0 (IQR 49.8–55.3) years, median time from diagnosis 3.0 (2.1–3.9) years) underwent unilateral FUS-STN. Within 2 weeks after treatment, five patients developed dyskinesia on the treated side, all resolved after levodopa dose adjustment. One patient developed mild contralateral motor weakness which fully resolved in 4 weeks. One patient developed dystonic foot and another hand and foot dystonia. The latter impaired gait and became functionally disabling initially. Both cases were well controlled with botulinum toxin injections. The off-medication motor MDS-UPDRS score for the treated side improved at 12 months by 68.7% (from 14.5 to 4.0, p=0.002), and the total motor MDS-UPDRS improved by 49.0% (from 26.5 to 13.0, p=0.002). Eleven patients (92%) reported global improvement 12 months after treatment., [Conclusion] Unilateral FUS-STN may be safe and effective to treat motor manifestations in patients with early PD. A larger confirmatory trial is warranted., [Trial registration number] NCT04692116.
Published: 2024

5. The role of veterinarians in zoonosis prevention: Advising families of immunocompromised children with pets

Author: Asociación Española de Pediatría, Ministerio de Ciencia e Innovación (España), Instituto de Salud Carlos III, European Commission, Fundación Mapfre, Comunidad de Madrid, García Sánchez, Paula [0000-0003-4866-6656], Romero-Trancón, David [0000-0002-5759-233X], Sainz, Talía [0000-0002-5301-0945], Calvo, Cristina [0000-0002-6503-3423], Iglesias, Irene [0000-0003-3472-6873], Perez-Hernando, Belén [0009-0004-2205-8446], Hurtado-Gallego, Jara [0000-0003-2509-857X], Alcolea, Sonia [0000-0003-1233-1723], Mendez-Echevarría, Ana [0000-0001-9078-0597], García Sánchez, Paula, Romero-Trancón, David, Sainz, Talía, Calvo, Cristina, Iglesias, Irene, Perez-Hernando, Belén, Hurtado-Gallego, Jara, Sánchez, Rocío, Alcolea, Sonia, Moya, Laura, Mendez-Echevarría, Ana, Asociación Española de Pediatría, Ministerio de Ciencia e Innovación (España), Instituto de Salud Carlos III, European Commission, Fundación Mapfre, Comunidad de Madrid, García Sánchez, Paula [0000-0003-4866-6656], Romero-Trancón, David [0000-0002-5759-233X], Sainz, Talía [0000-0002-5301-0945], Calvo, Cristina [0000-0002-6503-3423], Iglesias, Irene [0000-0003-3472-6873], Perez-Hernando, Belén [0009-0004-2205-8446], Hurtado-Gallego, Jara [0000-0003-2509-857X], Alcolea, Sonia [0000-0003-1233-1723], Mendez-Echevarría, Ana [0000-0001-9078-0597], García Sánchez, Paula, Romero-Trancón, David, Sainz, Talía, Calvo, Cristina, Iglesias, Irene, Perez-Hernando, Belén, Hurtado-Gallego, Jara, Sánchez, Rocío, Alcolea, Sonia, Moya, Laura, and Mendez-Echevarría, Ana
Abstract: Pet ownership is widespread, offering numerous benefits to individuals and families. However, the risk of zoonotic diseases must be carefully considered, especially for immunosuppressed patients. Knowledge gaps in preventive measures for zoonoses have been identified, underscoring the vital role of veterinarians in addressing this issue.
Published: 2024

6. Age, Origin and Functional Study of the Prevalent LDLR Mutation Causing Familial Hypercholesterolaemia in Gran Canaria

Author: Instituto de Salud Carlos III, European Commission, Fundación Canaria Instituto de Investigación Sanitaria de Canarias, Fundación Mapfre, Ministerio de Universidades (España), Suárez, Nicolás M. [0000-0001-8429-8374], Jebari-Benslaiman, Shifa [0000-0003-2079-6870], Brito-Casillas, Yeray [0000-0002-0707-7444], González-Lleo, Ana M. [0000-0001-8174-501X], Boronat, Mauro [0000-0001-8535-8543], Martín, César [0000-0002-4087-8729], Wägner, Ana M. [0000-0002-7663-9308], Suárez, Nicolás M., Jebari-Benslaiman, Shifa, Jiménez-Monzón, Roberto, Benito-Vicente, Asier, Brito-Casillas, Yeray, Garcés, Laida, González-Lleo, Ana M., Tugores, Antonio, Boronat, Mauro, Martín, César, Wägner, Ana M., Sánchez-Hernández, Rosa M., Instituto de Salud Carlos III, European Commission, Fundación Canaria Instituto de Investigación Sanitaria de Canarias, Fundación Mapfre, Ministerio de Universidades (España), Suárez, Nicolás M. [0000-0001-8429-8374], Jebari-Benslaiman, Shifa [0000-0003-2079-6870], Brito-Casillas, Yeray [0000-0002-0707-7444], González-Lleo, Ana M. [0000-0001-8174-501X], Boronat, Mauro [0000-0001-8535-8543], Martín, César [0000-0002-4087-8729], Wägner, Ana M. [0000-0002-7663-9308], Suárez, Nicolás M., Jebari-Benslaiman, Shifa, Jiménez-Monzón, Roberto, Benito-Vicente, Asier, Brito-Casillas, Yeray, Garcés, Laida, González-Lleo, Ana M., Tugores, Antonio, Boronat, Mauro, Martín, César, Wägner, Ana M., and Sánchez-Hernández, Rosa M.
Abstract: The p.(Tyr400_Phe402del) mutation in the LDL receptor (LDLR) gene is the most frequent cause of familial hypercholesterolaemia (FH) in Gran Canaria. The aim of this study was to determine the age and origin of this prevalent founder mutation and to explore its functional consequences. For this purpose, we obtained the haplotypic information of 14 microsatellite loci surrounding the mutation in one homozygous individual and 11 unrelated heterozygous family trios. Eight different mutation carrier haplotypes were identified, which were estimated to originate from a common ancestral haplotype 387 (110-1572) years ago. This estimation suggests that this mutation happened after the Spanish colonisation of the Canary Islands, which took place during the fifteenth century. Comprehensive functional studies of this mutation showed that the expressed LDL receptor was retained in the endoplasmic reticulum, preventing its migration to the cell surface, thus allowing us to classify this LDLR mutation as a class 2a, defective, pathogenic variant.
Published: 2023

7. Inborn errors of OAS-RNase L in SARS-CoV-2-related multisystem inflammatory syndrome in children

Author: Howard Hughes Medical Institute, Rockefeller University, St. Giles Foundation, National Institutes of Health (US), Instituto de Salud Carlos III, Ministerio de Ciencia e Innovación (España), Fundación Mapfre, Cabildo de Tenerife, Fundació La Marató de TV3, Centro de Investigación Biomédica en Red Enfermedades Raras (España), Consejo Superior de Investigaciones Científicas (España), European Commission, Pérez-Tur, Jordi [0000-0002-9111-1712], Lee, Danyel, Le Pen, Jeremie, Yatim, Ahmad, Dong, Beihua, Aquino, Yann, Ogishi, Masato, Pescarmona, Remi, Talouarn, Estelle, Rinchai, Darawan, Zhang, Peng, Perret, Magali, Rice, Charles M., Silverman, Robert H., Zhang, Shen-Ying, Casanova, Jean-Laurent, Liu, Zhiyong, Jordan, Iolanda, Bozdemir, Sefika Elmas, Bayhan, Gulsum Iclal, Beaufils, Camille, Bizien, Lucy, Bisiaux, Aurelie, Lei, Weite, Hasan, Milena, Chen, Jie, Gaughan, Christina, Asthana, Abhishek, Libri, Valentina, Luna, Joseph M., Jaffre, Fabrice, Hoffmann, H-Heinrich, Michailidis, Eleftherios, Moreews, Marion, Seeleuthner, Yoann, Bilguvar, Kaya, Mane, Shrikant, Flores, Carlos, Zhang, Yu, Arias, Andres A., Bailey, Rasheed, Schluter, Agatha, Milisavljevic, Baptiste, Bigio, Benedetta, Le Voyer, Tom, Materna, Marie, Gervais, Adrian, Moncada-Velez, Marcela, Pala, Francesca, Lazarov, Tomi, Levy, Romain, Neehus, Anna-Lena, Rosain, Jeremie, Peel, Jessica, Chan, Yi-Hao, Morin, Marie-Paule, Pino-Ramírez, Rosa María, Belkaya, Serkan, Lorenzo, Lazaro, Anton, Jordi, Delafontaine, Selket, Toubiana, Julie, Bajolle, Fanny, Fumado, Victoria, DeDiego, Marta L., Fidouh, Nadhira, Rozenberg, Flore, Pérez-Tur, Jordi, Chen, Shuibing, Evans, Todd, Geissmann, Frederic, Lebon, Pierre, Weiss, Susan R., Bonnet, Damien, Duval, Xavier, Pan-Hammarström, Qiang, Planas, Anna M., Meyts, Isabelle, Haerynck, Filomeen, Pujol, Aurora, Sancho-Shimizu, Vanessa, Dalgard, Clifford L., Bustamante, Jacinta, Puel, Anne, Boisson-Dupuis, Stéphanie, Boisson, Bertrand, Maniatis, Tom, Zhang, Qian, Bastard, Paul, Notarangelo, Luigi, Beziat, Vivien, Pérez de Diego, Rebeca, Rodriguez-Gallego, Carlos, Su, Helen C., Lifton, Richard P, Jouanguy, Emmanuelle, Cobat, Aurelie, Alsina, Laia, Keles, Sevgi, Haddad, Elie, Abel, Laurent, Belot, Alexandre, Quintana-Murci, Lluis, Howard Hughes Medical Institute, Rockefeller University, St. Giles Foundation, National Institutes of Health (US), Instituto de Salud Carlos III, Ministerio de Ciencia e Innovación (España), Fundación Mapfre, Cabildo de Tenerife, Fundació La Marató de TV3, Centro de Investigación Biomédica en Red Enfermedades Raras (España), Consejo Superior de Investigaciones Científicas (España), European Commission, Pérez-Tur, Jordi [0000-0002-9111-1712], Lee, Danyel, Le Pen, Jeremie, Yatim, Ahmad, Dong, Beihua, Aquino, Yann, Ogishi, Masato, Pescarmona, Remi, Talouarn, Estelle, Rinchai, Darawan, Zhang, Peng, Perret, Magali, Rice, Charles M., Silverman, Robert H., Zhang, Shen-Ying, Casanova, Jean-Laurent, Liu, Zhiyong, Jordan, Iolanda, Bozdemir, Sefika Elmas, Bayhan, Gulsum Iclal, Beaufils, Camille, Bizien, Lucy, Bisiaux, Aurelie, Lei, Weite, Hasan, Milena, Chen, Jie, Gaughan, Christina, Asthana, Abhishek, Libri, Valentina, Luna, Joseph M., Jaffre, Fabrice, Hoffmann, H-Heinrich, Michailidis, Eleftherios, Moreews, Marion, Seeleuthner, Yoann, Bilguvar, Kaya, Mane, Shrikant, Flores, Carlos, Zhang, Yu, Arias, Andres A., Bailey, Rasheed, Schluter, Agatha, Milisavljevic, Baptiste, Bigio, Benedetta, Le Voyer, Tom, Materna, Marie, Gervais, Adrian, Moncada-Velez, Marcela, Pala, Francesca, Lazarov, Tomi, Levy, Romain, Neehus, Anna-Lena, Rosain, Jeremie, Peel, Jessica, Chan, Yi-Hao, Morin, Marie-Paule, Pino-Ramírez, Rosa María, Belkaya, Serkan, Lorenzo, Lazaro, Anton, Jordi, Delafontaine, Selket, Toubiana, Julie, Bajolle, Fanny, Fumado, Victoria, DeDiego, Marta L., Fidouh, Nadhira, Rozenberg, Flore, Pérez-Tur, Jordi, Chen, Shuibing, Evans, Todd, Geissmann, Frederic, Lebon, Pierre, Weiss, Susan R., Bonnet, Damien, Duval, Xavier, Pan-Hammarström, Qiang, Planas, Anna M., Meyts, Isabelle, Haerynck, Filomeen, Pujol, Aurora, Sancho-Shimizu, Vanessa, Dalgard, Clifford L., Bustamante, Jacinta, Puel, Anne, Boisson-Dupuis, Stéphanie, Boisson, Bertrand, Maniatis, Tom, Zhang, Qian, Bastard, Paul, Notarangelo, Luigi, Beziat, Vivien, Pérez de Diego, Rebeca, Rodriguez-Gallego, Carlos, Su, Helen C., Lifton, Richard P, Jouanguy, Emmanuelle, Cobat, Aurelie, Alsina, Laia, Keles, Sevgi, Haddad, Elie, Abel, Laurent, Belot, Alexandre, and Quintana-Murci, Lluis
Abstract: Multisystem inflammatory syndrome in children (MIS-C) is a rare and severe condition that follows benign COVID-19. We report autosomal recessive deficiencies of OAS1, OAS2, or RNASEL in five unrelated children with MIS-C. The cytosolic double-stranded RNA (dsRNA)-sensing OAS1 and OAS2 generate 2'-5'-linked oligoadenylates (2-5A) that activate the single-stranded RNA-degrading ribonuclease L (RNase L). Monocytic cell lines and primary myeloid cells with OAS1, OAS2, or RNase L deficiencies produce excessive amounts of inflammatory cytokines upon dsRNA or severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) stimulation. Exogenous 2-5A suppresses cytokine production in OAS1-deficient but not RNase L-deficient cells. Cytokine production in RNase L-deficient cells is impaired by MDA5 or RIG-I deficiency and abolished by mitochondrial antiviral-signaling protein (MAVS) deficiency. Recessive OAS-RNase L deficiencies in these patients unleash the production of SARS-CoV-2-triggered, MAVS-mediated inflammatory cytokines by mononuclear phagocytes, thereby underlying MIS-C
Published: 2023

8. Full protection from SARS-CoV-2 brain infection and damage in susceptible transgenic mice conferred by MVA-CoV2-S vaccine candidate

Author: Consejo Superior de Investigaciones Científicas (España), Ministerio de Ciencia e Innovación (España), Agencia Estatal de Investigación (España), Instituto de Salud Carlos III, Junta de Andalucía, Ministerio de Sanidad (España), Banco Santander, Conferencia de Rectores de las Universidades Españolas, La Caixa, Ferrovial, Fundación Mapfre, European Commission, European Research Council, Villadiego, Javier, García-Arriaza, Juan, Ramírez Lorca, Reposo, García-Swinburn, Roberto, Cabello-Rivera, Daniel, Rosales-Nieves, Alicia E., Álvarez-Vergara, María I., Cala-Fernández, Fernando, García-Roldán, Ernesto, López-Ogáyar, Juan L., Zamora, Carmen, Astorgano, David, Albericio, Guillermo, Pérez Ramírez, Patricia, Muñoz-Cabello, Ana M., Pascual Bravo, Alberto, Esteban, Mariano, López-Barneo, José, Toledo-Aral, Juan José, Consejo Superior de Investigaciones Científicas (España), Ministerio de Ciencia e Innovación (España), Agencia Estatal de Investigación (España), Instituto de Salud Carlos III, Junta de Andalucía, Ministerio de Sanidad (España), Banco Santander, Conferencia de Rectores de las Universidades Españolas, La Caixa, Ferrovial, Fundación Mapfre, European Commission, European Research Council, Villadiego, Javier, García-Arriaza, Juan, Ramírez Lorca, Reposo, García-Swinburn, Roberto, Cabello-Rivera, Daniel, Rosales-Nieves, Alicia E., Álvarez-Vergara, María I., Cala-Fernández, Fernando, García-Roldán, Ernesto, López-Ogáyar, Juan L., Zamora, Carmen, Astorgano, David, Albericio, Guillermo, Pérez Ramírez, Patricia, Muñoz-Cabello, Ana M., Pascual Bravo, Alberto, Esteban, Mariano, López-Barneo, José, and Toledo-Aral, Juan José
Abstract: Vaccines against SARS-CoV-2 have been shown to be safe and effective but their protective efficacy against infection in the brain is yet unclear. Here, in the susceptible transgenic K18-hACE2 mouse model of severe coronavirus disease 2019 (COVID-19), we report a spatiotemporal description of SARS-CoV-2 infection and replication through the brain. SARS-CoV-2 brain replication occurs primarily in neurons, leading to neuronal loss, signs of glial activation and vascular damage in mice infected with SARS-CoV-2. One or two doses of a modified vaccinia virus Ankara (MVA) vector expressing the SARS-CoV-2 spike (S) protein (MVA-CoV2-S) conferred full protection against SARS-CoV-2 cerebral infection, preventing virus replication in all areas of the brain and its associated damage. This protection was maintained even after SARS-CoV-2 reinfection. These findings further support the use of MVA-CoV2-S as a promising vaccine candidate against SARS-CoV-2/COVID-19.
Published: 2023

9. Contractility of isolated colonic smooth muscle strips from rats treated with cancer chemotherapy: differential effects of cisplatin and vincristine

Author: Fundación Mapfre, Ministerio de Ciencia, Innovación y Universidades (España), Grupo Español de Motilidad Digestiva, Asociación Española de Gastroenterología, López-Tofiño, Y., Barragán del Caz, L. F., Benítez-Álvarez, D., Molero-Mateo, P., Nurgali, K., Vera, Gema, Bagües, Ana, Abalo, Raquel, Fundación Mapfre, Ministerio de Ciencia, Innovación y Universidades (España), Grupo Español de Motilidad Digestiva, Asociación Española de Gastroenterología, López-Tofiño, Y., Barragán del Caz, L. F., Benítez-Álvarez, D., Molero-Mateo, P., Nurgali, K., Vera, Gema, Bagües, Ana, and Abalo, Raquel
Abstract: Background: Certain antineoplastic drugs cause gastrointestinal disorders even after the end of treatment. Enteric neuropathy has been associated with some of these alterations. Our goal was to assess the impact of repeated treatment with cisplatin and vincristine on the contractility of circular and longitudinal muscle strips isolated from the rat colon. Methods: Two cohorts of male rats were used: in cohort 1, rats received one intraperitoneal (ip) injection of saline or cisplatin (2 mg kg week) on the first day of weeks 1–5; in cohort 2, rats received two cycles of five daily ip injections (Monday to Friday, weeks 1–2) of saline or vincristine (0.1 mg kg day). Body weight and food and water intake were monitored throughout the study. One week after treatment, responses of colonic smooth muscle strips to acetylcholine (10–10 M) and electrical field stimulation (EFS, 0.1–20 Hz), before and after atropine (10 M), were evaluated in an organ bath. Results: Both drugs decreased body weight gain. Compared to saline, cisplatin significantly decreased responses of both longitudinal and circular smooth muscle strips to EFS, whereas vincristine tended to increase them, although in a non-significant manner. No differences were observed in the muscle response to acetylcholine. Atropine abolished the contractile responses induced by acetylcholine, although those induced by EFS were only partially reduced in the presence of atropine. Conclusion: The findings suggest that although both drugs cause the development of enteric neuropathy, this seems to have a functional impact only in cisplatin-treated animals. Understanding the effects of chemotherapy on gastrointestinal motor function is vital for enhancing the quality of life of cancer patients.
Published: 2023

10. microRNAs-mediated regulation of insulin signaling in white adipose tissue during aging: Role of caloric restriction [Dataset]

Author: Comunidad de Madrid, Universidad Rey Juan Carlos, Ministerio de Economía y Competitividad (España), Ministerio de Ciencia e Innovación (España), Agencia Estatal de Investigación (España), Fundación Mapfre, Corrales, Patricia, Martin-Taboada, Marina, Vivas-García, Yurena, Torres, Lucia, Ramírez-Jiménez, Laura, López, Yamila, Horrillo, Daniel, Vila-Bedmar, Rocío, Barber-Cano, Eloisa, Izquierdo-Lahuerta, Adriana, Peña-Chilet, María, Martínez, Carmen, Dopazo, Joaquín, Ros, Manuel, Medina-Gómez, Gema, Comunidad de Madrid, Universidad Rey Juan Carlos, Ministerio de Economía y Competitividad (España), Ministerio de Ciencia e Innovación (España), Agencia Estatal de Investigación (España), Fundación Mapfre, Corrales, Patricia, Martin-Taboada, Marina, Vivas-García, Yurena, Torres, Lucia, Ramírez-Jiménez, Laura, López, Yamila, Horrillo, Daniel, Vila-Bedmar, Rocío, Barber-Cano, Eloisa, Izquierdo-Lahuerta, Adriana, Peña-Chilet, María, Martínez, Carmen, Dopazo, Joaquín, Ros, Manuel, and Medina-Gómez, Gema
Abstract: Caloric restriction is a non-pharmacological intervention known to ameliorate the metabolic defects associated with aging, including insulin resistance. The levels of miRNA expression may represent a predictive tool for aging-related alterations. In order to investigate the role of miRNAs underlying insulin resistance in adipose tissue during the early stages of aging, 3- and 12-month-old male animals fed ad libitum, and 12-month-old male animals fed with a 20% caloric restricted diet were used. In this work we demonstrate that specific miRNAs may contribute to the impaired insulin-stimulated glucose metabolism specifically in the subcutaneous white adipose tissue, through the regulation of target genes implicated in the insulin signaling cascade. Moreover, the expression of these miRNAs is modified by caloric restriction in middle-aged animals, in accordance with the improvement of the metabolic state. Overall, our work demonstrates that alterations in posttranscriptional gene expression because of miRNAs dysregulation might represent an endogenous mechanism by which insulin response in the subcutaneous fat depot is already affected at middle age. Importantly, caloric restriction could prevent this modulation, demonstrating that certain miRNAs could constitute potential biomarkers of age-related metabolic alterations.
Published: 2023

11. microRNAs-mediated regulation of insulin signaling in white adipose tissue during aging: Role of caloric restriction

Author: Comunidad de Madrid, Universidad Rey Juan Carlos, Ministerio de Economía y Competitividad (España), Ministerio de Ciencia e Innovación (España), Agencia Estatal de Investigación (España), Fundación Mapfre, Corrales, Patricia, Martin-Taboada, Marina, Vivas-García, Yurena, Torres, Lucia, Ramírez-Jiménez, Laura, López, Yamila, Horrillo, Daniel, Vila-Bedmar, Rocío, Barber-Cano, Eloisa, Izquierdo-Lahuerta, Adriana, Peña-Chilet, María, Martínez, Carmen, Dopazo, Joaquín, Ros, Manuel, Medina-Gómez, Gema, Comunidad de Madrid, Universidad Rey Juan Carlos, Ministerio de Economía y Competitividad (España), Ministerio de Ciencia e Innovación (España), Agencia Estatal de Investigación (España), Fundación Mapfre, Corrales, Patricia, Martin-Taboada, Marina, Vivas-García, Yurena, Torres, Lucia, Ramírez-Jiménez, Laura, López, Yamila, Horrillo, Daniel, Vila-Bedmar, Rocío, Barber-Cano, Eloisa, Izquierdo-Lahuerta, Adriana, Peña-Chilet, María, Martínez, Carmen, Dopazo, Joaquín, Ros, Manuel, and Medina-Gómez, Gema
Abstract: Caloric restriction is a non-pharmacological intervention known to ameliorate the metabolic defects associated with aging, including insulin resistance. The levels of miRNA expression may represent a predictive tool for aging-related alterations. In order to investigate the role of miRNAs underlying insulin resistance in adipose tissue during the early stages of aging, 3- and 12-month-old male animals fed ad libitum, and 12-month-old male animals fed with a 20% caloric restricted diet were used. In this work we demonstrate that specific miRNAs may contribute to the impaired insulin-stimulated glucose metabolism specifically in the subcutaneous white adipose tissue, through the regulation of target genes implicated in the insulin signaling cascade. Moreover, the expression of these miRNAs is modified by caloric restriction in middle-aged animals, in accordance with the improvement of the metabolic state. Overall, our work demonstrates that alterations in posttranscriptional gene expression because of miRNAs dysregulation might represent an endogenous mechanism by which insulin response in the subcutaneous fat depot is already affected at middle age. Importantly, caloric restriction could prevent this modulation, demonstrating that certain miRNAs could constitute potential biomarkers of age-related metabolic alterations.
Published: 2023

12. Immunocompromised Children and Young Patients Living with Pets: Gaps in Knowledge to Avoid Zoonosis

Author: Asociación Española de Pediatría, Fundación Mapfre, Instituto de Salud Carlos III, García Sánchez, Paula [0000-0003-4866-6656], Sainz, Talía [0000-0002-5301-0945], Calvo, Cristina [0000-0002-6503-3423], Iglesias, Irene [0000-0003-3472-6873], Bueno, David [0000-0003-3392-3285], Frauca, Esteban [0000-0002-4010-3018], Ramos-Boluda, Esther [0000-0001-6743-9198], Alcolea-Sanchez, A. [0000-0003-3418-455X], García-Guereta, Luis [0000-0003-4675-365X], Alonso-Melgar, Angel [0000-0001-7129-7196], Esperón, Fernando [0000-0002-8810-5071], Mendez-Echevarría, Ana [0000-0002-7455-9080], García Sánchez, Paula, Aguilar-Valero, E., Sainz, Talía, Calvo, Cristina, Iglesias, Irene, Bueno, David, Frauca, Esteban, Ramos-Boluda, Esther, Alcolea-Sanchez, A., García-Guereta, Luis, Alonso-Melgar, Angel, Esperón, Fernando, Mendez-Echevarría, Ana, Asociación Española de Pediatría, Fundación Mapfre, Instituto de Salud Carlos III, García Sánchez, Paula [0000-0003-4866-6656], Sainz, Talía [0000-0002-5301-0945], Calvo, Cristina [0000-0002-6503-3423], Iglesias, Irene [0000-0003-3472-6873], Bueno, David [0000-0003-3392-3285], Frauca, Esteban [0000-0002-4010-3018], Ramos-Boluda, Esther [0000-0001-6743-9198], Alcolea-Sanchez, A. [0000-0003-3418-455X], García-Guereta, Luis [0000-0003-4675-365X], Alonso-Melgar, Angel [0000-0001-7129-7196], Esperón, Fernando [0000-0002-8810-5071], Mendez-Echevarría, Ana [0000-0002-7455-9080], García Sánchez, Paula, Aguilar-Valero, E., Sainz, Talía, Calvo, Cristina, Iglesias, Irene, Bueno, David, Frauca, Esteban, Ramos-Boluda, Esther, Alcolea-Sanchez, A., García-Guereta, Luis, Alonso-Melgar, Angel, Esperón, Fernando, and Mendez-Echevarría, Ana
Abstract: Background and Objectives. Although pets are known to be benefcial for children, they could also imply risks for immunocompromised ones. We report the prevalence of children and young patients living with pets in a cohort of immunosuppressed pediatric patients and describe risk behaviors for acquiring zoonosis and compliance with veterinary recommendations. Methods. A cross-sectional, ob-servational study was performed in a large tertiary hospital in Madrid, including immunosuppressed patients from diferent regions of Spain. Te participants were asked to complete an online questionnaire. Results. Two hundred and eighty-four responses were received: 62.3% solid organ transplantation (177/284), 22.8% hematopoietic stem cell transplantation (65/284), and 14.8% inborn errors of immunity (42/284). Te median age was 11 years (interquartile range 5.9–15.4), and 55% were boys (156/284). Up to 45% (130/284) of the respondents lived with 201 pets (74% of them dogs and cats). Half of the patients owning dogs or cats did not comply with at least one of the recommendations regarding vaccination, deworming, feeding, and/or veterinarian recommended controls. Te poorest fndings were related to deworming regimens. Only 42.8% (117/273) of the participants received specifc recommendations from their healthcare professionals about companion animals. However, up to 97% of the families considering acquiring a pet did so when the professional did not contraindicate it (31/32), while 72% of the families having pets got rid of their pets when they were advised against animals (8/11). Conclusions. Pet ownership is frequent among immunocompromised children. Tey presented risky exposures for acquiring zoonoses, and basic veterinary recommendations were not frequently followed. Te opinion of professionals signifcantly infuenced the decision to acquire pets, but less than half of the families received recommendations in this regard.
Published: 2023

13. Assessing falls in the elderly population using G-STRIDE foot-mounted inertial sensor

Author: Ministerio de Ciencia e Innovación (España), European Commission, Fundación Mapfre, Neira Álvarez, Marta [0000-0002-5488-7749], Jiménez Ruíz, Antonio Ramón [0000-0001-9771-1930], García Villamil, Guillermo [0000-0002-3869-4410], Huertas-Hoyas, Elisabet [0000-0002-5840-541X], Espinoza Cerda, Maria Teresa [0000-0002-2468-7893], Pérez Delgado, Laura [0000-0001-7611-1434], Reina Robles, Elena, Del Ama Espinosa, Antonio José [0000-0001-6215-2593], Ruiz Ruiz, Luisa [0000-0003-0316-7781], García de Villa, Sara {0000-0002-7054-5810], Rodríguez Sánchez, Cristina, Neira Álvarez, Marta, Jiménez Ruíz, Antonio Ramón, García Villamil, Guillermo, Huertas-Hoyas, Elisabet, Espinoza Cerda, Maria Teresa, Pérez Delgado, Laura, Del Ama Espinosa, Antonio José, Ruiz Ruiz, Luisa, García de Villa, Sara, Ministerio de Ciencia e Innovación (España), European Commission, Fundación Mapfre, Neira Álvarez, Marta [0000-0002-5488-7749], Jiménez Ruíz, Antonio Ramón [0000-0001-9771-1930], García Villamil, Guillermo [0000-0002-3869-4410], Huertas-Hoyas, Elisabet [0000-0002-5840-541X], Espinoza Cerda, Maria Teresa [0000-0002-2468-7893], Pérez Delgado, Laura [0000-0001-7611-1434], Reina Robles, Elena, Del Ama Espinosa, Antonio José [0000-0001-6215-2593], Ruiz Ruiz, Luisa [0000-0003-0316-7781], García de Villa, Sara {0000-0002-7054-5810], Rodríguez Sánchez, Cristina, Neira Álvarez, Marta, Jiménez Ruíz, Antonio Ramón, García Villamil, Guillermo, Huertas-Hoyas, Elisabet, Espinoza Cerda, Maria Teresa, Pérez Delgado, Laura, Del Ama Espinosa, Antonio José, Ruiz Ruiz, Luisa, and García de Villa, Sara
Abstract: Falls are one of the main concerns in the elderly population due to their high prevalence and associated consequences. Guidelines for the management of the elder with falls are comprised of multidimensional assessments, especially gait and balance. Daily clinical practice needs for timely, effortless, and precise tools to assess gait. This work presents the clinical validation of the G-STRIDE system, a 6-axis inertial measurement unit (IMU) with onboard processing algorithms, that allows the calculation of walking-related metrics correlated with clinical markers of fall risk. A cross-sectional case-control study was conducted with 163 participants (falls and non-falls groups). All volunteers were assessed with clinical scales and conducted a 15-min walking test at a self-selected pace while wearing the G-STRIDE. G-STRIDE is a low-cost solution to facilitate the transfer to society and clinical evaluations. It is open hardware and flexible and, thus, has the advantage of providing runtime data processing. Walking descriptors were derived from the device, and a correlation analysis was conducted between walking and clinical variables. G-STRIDE allowed measuring walking parameters in non-restricted walking conditions (e.g. hallway). Walking parameters statistically discriminate between falls and non-falls groups. We found good/excellent estimation accuracy (ICC = 0.885; p<0.000) for walking speed, showing good/excellent correlation between gait speed and several clinical variables. G-STRIDE can calculate walking-related metrics that allow for discrimination between falls and non-falls groups, which correlates with clinical indicators of fall risk. A preliminary fall-risk assessment based on the walking parameters was found to improve the Timed Up and Go test in the identification of fallers.
Published: 2023

14. Optimized vaccine candidate MVA-S(3P) fully protects against SARS-CoV-2 infection in hamsters

Author: Instituto de Salud Carlos III, Ministerio de Sanidad (España), Conferencia de Rectores de las Universidades Españolas, Banco Santander, Consejo Superior de Investigaciones Científicas (España), Centro de Investigación Biomédica en Red de Enfermedades Infecciosas (España), European Commission, La Caixa, Ferrovial, Fundación Mapfre, Agencia Estatal de Investigación (España), Ministerio de Ciencia, Innovación y Universidades (España), KU Leuven, Research Foundation - Flanders, https://ror.org/02gfc7t72, Abdelnabi, Rana, Pérez, Patricia, Astorgano, David, Albericio, Guillermo, Kerstens, Winnie, Thibaut, Hendrik Jan, Coelmont, Lotte, Weynand, Birgit, Labiod, Nuria, Delgado, Rafael, Montenegro, Dolores, Puentes, Eugenia, Rodríguez, Esteban, Neyts, Johan, Dallmeier, Kai, Esteban, Mariano, García-Arriaza, Juan, Instituto de Salud Carlos III, Ministerio de Sanidad (España), Conferencia de Rectores de las Universidades Españolas, Banco Santander, Consejo Superior de Investigaciones Científicas (España), Centro de Investigación Biomédica en Red de Enfermedades Infecciosas (España), European Commission, La Caixa, Ferrovial, Fundación Mapfre, Agencia Estatal de Investigación (España), Ministerio de Ciencia, Innovación y Universidades (España), KU Leuven, Research Foundation - Flanders, https://ror.org/02gfc7t72, Abdelnabi, Rana, Pérez, Patricia, Astorgano, David, Albericio, Guillermo, Kerstens, Winnie, Thibaut, Hendrik Jan, Coelmont, Lotte, Weynand, Birgit, Labiod, Nuria, Delgado, Rafael, Montenegro, Dolores, Puentes, Eugenia, Rodríguez, Esteban, Neyts, Johan, Dallmeier, Kai, Esteban, Mariano, and García-Arriaza, Juan
Abstract: The development of novel optimized vaccines against coronavirus disease 2019 (COVID-19) that are capable of controlling the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic and the appearance of different variants of concern (VoC) is needed to fully prevent the transmission of the virus. In the present study, we describe the enhanced immunogenicity and efficacy elicited in hamsters by a modified vaccinia virus Ankara (MVA) vector expressing a full-length prefusion-stabilized SARS-CoV-2 spike (S) protein [termed MVA-S(3P)]. Hamsters vaccinated with one or two doses of MVA-S(3P) developed high titers of S-binding IgG antibodies and neutralizing antibodies against the ancestral Wuhan SARS-CoV-2 virus and VoC beta, gamma, and delta, as well as against omicron, although with a somewhat lower neutralization activity. After SARS-CoV-2 challenge, vaccinated hamsters did not lose body weight as compared to matched placebo (MVA-WT) controls. Consistently, vaccinated hamsters exhibited significantly reduced viral RNA in the lungs and nasal washes, and no infectious virus was detected in the lungs in comparison to controls. Furthermore, almost no lung histopathology was detected in MVA-S(3P)-vaccinated hamsters, which also showed significantly reduced levels of proinflammatory cytokines in the lungs compared to unvaccinated hamsters. These results reinforce the use of MVA-S(3P) as a vaccine candidate against COVID-19 in clinical trials.
Published: 2023

15. A combination of aerobic exercise at fatmax and low resistance training increases fat oxidation and maintains muscle mass, in women waiting for bariatric surgery

Author: Conferencia de Rectores de las Universidades Españolas, Consejo Superior de Investigaciones Científicas (España), Universidad Europea de Madrid, Fundación Mapfre, Picó-Sirvent, Inés, Manresa-Rocamora, Agustín, Aracil-Marco, Adolfo, Moya-Ramón, Manuel, Conferencia de Rectores de las Universidades Españolas, Consejo Superior de Investigaciones Científicas (España), Universidad Europea de Madrid, Fundación Mapfre, Picó-Sirvent, Inés, Manresa-Rocamora, Agustín, Aracil-Marco, Adolfo, and Moya-Ramón, Manuel
Abstract: [Purpose]: There is no consensus on the best exercise recommendation for women affected by severe obesity while they are waiting for bariatric surgery. For this reason, the effects of a combination of aerobic exercise performed at the intensity at which maximal fat oxidation is reached (Fatmax) with low-intensity resistance training were studied., [Materials and Methods]: Twenty sedentary middle-aged Caucasian women (43.2 ± 7.5 years, BMI = 46.5 ± 5.9 kg·m−2) were allocated to a control group (CG, n = 10) that followed solely the conventional preoperative care or to an experimental group (EG, n = 10) that, in addition, performed a 12-week individualized and supervised physical activity program (PAP) that combined aerobic training at Fatmax with low-intensity resistance training., [Results]: After the PAP, maximal fat oxidation during exercise increased in the EG (0.187 ± 0.068 vs 0.239 ± 0.080 g·min-1, p = 0.025, pre vs. post, respectively), but resting fat oxidation did not (0.088 ± 0.034 vs 0.092 ± 0.029 g·min-1, p = 0.685, pre vs. post, respectively). Additionally, the resting metabolic rate in the EG was also unchanged (1869 ± 406 vs. 1894 ± 336 kcal; p = 0.827, pre vs. post, respectively), probably because of the effects of resistance training on the maintenance of fat-free mass. No significant changes were observed in the CG., [Conclusion]: A PAP that combines aerobic exercise at Fatmax with low resistance training may counteract some of the deleterious side effects of the standard presurgical care of women waiting for bariatric surgery and increase maximal fat oxidation during exercise.
Published: 2022

16. Serum angiotensin-converting enzyme 2 as a potential biomarker for SARS-CoV-2 infection and vaccine efficacy

Author: Instituto de Salud Carlos III, Generalitat Valenciana, Instituto de Investigación Sanitaria y Biomédica de Alicante, Agencia Estatal de Investigación (España), Ministerio de Ciencia, Innovación y Universidades (España), European Commission, Consejo Superior de Investigaciones Científicas (España), Banco Santander, Ministerio de Sanidad (España), Conferencia de Rectores de las Universidades Españolas, Ferrovial, Fundación Mapfre, Ministerio de Economía y Competitividad (España), Lennol, Matthew P., García-Ayllón, María-Salud, Esteban, Mariano, García-Arriaza, Juan, Sáez-Valero, Javier, Instituto de Salud Carlos III, Generalitat Valenciana, Instituto de Investigación Sanitaria y Biomédica de Alicante, Agencia Estatal de Investigación (España), Ministerio de Ciencia, Innovación y Universidades (España), European Commission, Consejo Superior de Investigaciones Científicas (España), Banco Santander, Ministerio de Sanidad (España), Conferencia de Rectores de las Universidades Españolas, Ferrovial, Fundación Mapfre, Ministerio de Economía y Competitividad (España), Lennol, Matthew P., García-Ayllón, María-Salud, Esteban, Mariano, García-Arriaza, Juan, and Sáez-Valero, Javier
Abstract: Various species of the SARS-CoV-2 host cell receptor, the angiotensin-converting enzyme 2 (ACE2), are present in serum, which may result from virus entry and subsequent proteolytic processing of the membrane receptor. We have recently demonstrated changes of particular ACE2 species in virus infected humans, either cleaved fragments or circulating full-length species. Here, we further explore the potential of serum ACE2 as a biomarker to test SARS-CoV-2 infection and vaccine efficacy in virus susceptible transgenic K18-hACE2 mice expressing human ACE2. First, in serum samples derived from K18-hACE2 mice challenged with a lethal dose of SARS-CoV-2, we observed an increase in the levels of cleaved ACE2 fragment at day 2 post-challenge, which may represent the subsequent proteolytic processing through virus entry. These elevated levels were maintained until the death of the animals at day 6 post-challenge. The circulating full-length ACE2 form displayed a sizable peak at day 4, which declined at day 6 post-challenge. Noticeably, immunization with two doses of the MVA-CoV2-S vaccine candidate prevented ACE2 cleaved changes in serum of animals challenged with a lethal dose of SARS-CoV-2. The efficacy of the MVA-CoV2-S was extended to vaccinated mice after virus re-challenge. These findings highlight that ACE2 could be a potential serum biomarker for disease progression and vaccination against SARS-CoV-2.
Published: 2022

17. Balancing the Risks and Benefits of Pet Ownership in Pediatric Transplant Recipients

Author: Asociación Española de Pediatría, Fundación Mapfre, Instituto de Salud Carlos III, Ministerio de Ciencia e Innovación (España), European Commission, Iglesias, Irene [0000-0003-3472-6873], Falces-Romero, Iker [0000-0001-5888-7706], García Sánchez, Paula, Iglesias, Irene, Falces-Romero, Iker, Serrano-Villar, María, Calvo, Cristina, Alcolea, Sonia, Sainz, Talía, Mendez-Echevarría, Ana, Asociación Española de Pediatría, Fundación Mapfre, Instituto de Salud Carlos III, Ministerio de Ciencia e Innovación (España), European Commission, Iglesias, Irene [0000-0003-3472-6873], Falces-Romero, Iker [0000-0001-5888-7706], García Sánchez, Paula, Iglesias, Irene, Falces-Romero, Iker, Serrano-Villar, María, Calvo, Cristina, Alcolea, Sonia, Sainz, Talía, and Mendez-Echevarría, Ana
Abstract: In recent decades, the number of pediatric transplantations and their survival rates have increased. Psychological problems and poorer quality of life are notable among children undergoing transplantation and can have long-lasting consequences and affect immunosuppressive therapy adherence. Pet ownership and animal contact have been associated with physical, mental, and social health benefits. Despite these potential benefits, however, companion animals are known to be a source of infection, which is one of the main concerns for clinicians. Because of immunosuppression, these children are particularly vulnerable to infections. Zoonoses comprise a long list of infectious diseases and represent a major public health problem. Nevertheless, many families and most healthcare providers are unaware of these potential risks, and there is a worrisome lack of recommendations to manage the risk-benefit balance, which could pose a risk for acquiring a zoonosis. Furthermore, no data are available on the number of transplanted patients with pets, and this risk-benefit balance is difficult to adequately evaluate. In this document, we review the currently available evidence regarding the epidemiology of zoonotic infections in patients undergoing transplantation, focusing on pediatric patients from a risk-benefit perspective, to help inform decision-making for clinicians. Families and healthcare professionals should be aware of the risks, and clinicians should actively screen for pets and offer comprehensive information as part of routine clinical practice. A multidisciplinary approach will ensure proper care of patients and pets and will establish preventive measures to ensure patients are safe living with their pets.
Published: 2022

18. MVA-CoV2-S vaccine candidate confers full protection from SARS-CoV-2 brain infection and damage in susceptible transgenic mice

Author: Consejo Superior de Investigaciones Científicas (España), Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), Instituto de Salud Carlos III, Red de Terapia Celular (España), Junta de Andalucía, Ministerio de Sanidad (España), Banco Santander, Conferencia de Rectores de las Universidades Españolas, La Caixa, Ferrovial, Fundación Mapfre, European Research Council, European Commission, Villadiego, Javier [0000-0003-2131-9013], García-Swinburn, Roberto [0000-0002-8154-0265], Rosales-Nieves, Alicia E. [0000-0001-9119-1604], Muñoz-Cabello, Ana M. [0000-0002-8047-768X], Pascual Bravo, Alberto [0000-0001-5459-6207], Villadiego, Javier, García-Arriaza, Juan, Ramírez Lorca, Reposo, Cabello-Rivera, Daniel, Álvarez-Vergara, María I., Cala-Fernández, Fernando, García-Swinburn, Roberto, García-Roldán, Ernesto, López-Ogáyar, Juan L., Zamora, Carmen, Astorgano, David, Pérez Ramírez, Patricia, Rosales-Nieves, Alicia E., Muñoz-Cabello, Ana M., Pascual Bravo, Alberto, Esteban, Mariano, López-Barneo, José, Toledo-Aral, Juan José, Consejo Superior de Investigaciones Científicas (España), Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), Instituto de Salud Carlos III, Red de Terapia Celular (España), Junta de Andalucía, Ministerio de Sanidad (España), Banco Santander, Conferencia de Rectores de las Universidades Españolas, La Caixa, Ferrovial, Fundación Mapfre, European Research Council, European Commission, Villadiego, Javier [0000-0003-2131-9013], García-Swinburn, Roberto [0000-0002-8154-0265], Rosales-Nieves, Alicia E. [0000-0001-9119-1604], Muñoz-Cabello, Ana M. [0000-0002-8047-768X], Pascual Bravo, Alberto [0000-0001-5459-6207], Villadiego, Javier, García-Arriaza, Juan, Ramírez Lorca, Reposo, Cabello-Rivera, Daniel, Álvarez-Vergara, María I., Cala-Fernández, Fernando, García-Swinburn, Roberto, García-Roldán, Ernesto, López-Ogáyar, Juan L., Zamora, Carmen, Astorgano, David, Pérez Ramírez, Patricia, Rosales-Nieves, Alicia E., Muñoz-Cabello, Ana M., Pascual Bravo, Alberto, Esteban, Mariano, López-Barneo, José, and Toledo-Aral, Juan José
Abstract: The protective efficacy of vaccines against SARS-CoV-2 infection in the brain is yet unclear. Here, in the susceptible transgenic K18-hACE2 mouse model of severe COVID-19 disease, we report a detailed spatiotemporal description of the SARS-CoV-2 infection and replication in different areas of the brain. Remarkably, SARS-CoV-2 brain replication occurs primarily in neurons, producing important neuropathological alterations such as neuronal loss, incipient signs of neuroinflammation, and vascular damage in SARS-CoV-2 infected mice. Notably, one or two doses of a modified vaccinia virus Ankara (MVA) vector expressing the SARS-CoV-2 spike (S) protein (MVA-CoV2-S) conferred full protection against SARS-CoV-2 cerebral infection, preventing virus replication in all areas of the brain and its associated damage. This protection was maintained even after SARS-CoV-2 reinfection. To our knowledge, this is the first study of a COVID-19 vaccine candidate showing 100% efficacy against SARS-CoV-2 brain infection and damage, reinforcing the use of MVA-CoV2-S as a promising vaccine candidate against SARS-CoV-2/COVID-19, worth to move forward into clinical trials.
Published: 2022

19. A Single Dose of an MVA Vaccine Expressing a Prefusion-Stabilized SARS-CoV-2 Spike Protein Neutralizes Variants of Concern and Protects Mice From a Lethal SARS-CoV-2 Infection

Author: Ministerio de Sanidad (España), Instituto de Salud Carlos III, Banco Santander, Conferencia de Rectores de las Universidades Españolas, Consejo Superior de Investigaciones Científicas (España), Fundación la Caixa, Ferrovial, Fundación Mapfre, Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), European Commission, Pérez Ramírez, Patricia, Lázaro-Frías, Adrián, Zamora, Carmen, Sánchez-Cordón, P. J., Astorgano, David, Luczkowiak, Joanna, Delgado, Rafael, Casasnovas, José María, Esteban, Mariano, García-Arriaza, Juan, Ministerio de Sanidad (España), Instituto de Salud Carlos III, Banco Santander, Conferencia de Rectores de las Universidades Españolas, Consejo Superior de Investigaciones Científicas (España), Fundación la Caixa, Ferrovial, Fundación Mapfre, Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), European Commission, Pérez Ramírez, Patricia, Lázaro-Frías, Adrián, Zamora, Carmen, Sánchez-Cordón, P. J., Astorgano, David, Luczkowiak, Joanna, Delgado, Rafael, Casasnovas, José María, Esteban, Mariano, and García-Arriaza, Juan
Abstract: We generated an optimized COVID-19 vaccine candidate based on the modified vaccinia virus Ankara (MVA) vector expressing a full-length prefusion-stabilized SARS-CoV-2 spike (S) protein, termed MVA-CoV2-S(3P). The S(3P) protein was expressed at higher levels (2-fold) than the non-stabilized S in cells infected with the corresponding recombinant MVA viruses. One single dose of MVA-CoV2-S(3P) induced higher IgG and neutralizing antibody titers against parental SARS-CoV-2 and variants of concern than MVA-CoV2-S in wild-type C57BL/6 and in transgenic K18-hACE2 mice. In immunized C57BL/6 mice, two doses of MVA-CoV2-S or MVA-CoV2-S(3P) induced similar levels of SARS-CoV-2-specific B- and T-cell immune responses. Remarkably, a single administration of MVA-CoV2-S(3P) protected all K18-hACE2 mice from morbidity and mortality caused by SARS-CoV-2 infection, reducing SARS-CoV-2 viral loads, histopathological lesions, and levels of pro-inflammatory cytokines in the lungs. These results demonstrated that expression of a novel full-length prefusion-stabilized SARS-CoV-2 S protein by the MVA poxvirus vector enhanced immunogenicity and efficacy against SARS-CoV-2 in animal models, further supporting MVA-CoV2-S(3P) as an optimized vaccine candidate for clinical trials.
Published: 2022

20. Full efficacy and long-term immunogenicity induced by the SARS-CoV-2 vaccine candidate MVA-CoV2-S in mice

Author: Instituto de Salud Carlos III, Banco Santander, Conferencia de Rectores de las Universidades Españolas, Ministerio de Sanidad (España), Fundación la Caixa, Ferrovial, Fundación Mapfre, Consejo Superior de Investigaciones Científicas (España), Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), European Commission, Centro de Investigación en Sanidad Animal (España), CSIC - Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA), Lázaro-Frías, Adrián, Pérez Ramírez, Patricia, Zamora, Carmen, Sánchez-Cordón, P. J., Guzmán, María, Luczkowiak, Joanna, Delgado, Rafael, Casasnovas, José María, Esteban, Mariano, García-Arriaza, Juan, Instituto de Salud Carlos III, Banco Santander, Conferencia de Rectores de las Universidades Españolas, Ministerio de Sanidad (España), Fundación la Caixa, Ferrovial, Fundación Mapfre, Consejo Superior de Investigaciones Científicas (España), Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), European Commission, Centro de Investigación en Sanidad Animal (España), CSIC - Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA), Lázaro-Frías, Adrián, Pérez Ramírez, Patricia, Zamora, Carmen, Sánchez-Cordón, P. J., Guzmán, María, Luczkowiak, Joanna, Delgado, Rafael, Casasnovas, José María, Esteban, Mariano, and García-Arriaza, Juan
Abstract: Two doses of the MVA-CoV2-S vaccine candidate expressing the SARS-CoV-2 spike (S) protein protected K18-hACE2 transgenic mice from a lethal dose of SARS-CoV-2. This vaccination regimen prevented virus replication in the lungs, reduced lung pathology, and diminished levels of pro-inflammatory cytokines. High titers of IgG antibodies against S and receptor-binding domain (RBD) proteins and of neutralizing antibodies were induced against parental virus and variants of concern, markers that correlated with protection. Similar SARS-CoV-2-specific antibody responses were observed at prechallenge and postchallenge in the two-dose regimen, while the single-dose treatment does not avoid vaccine breakthrough infection. All vaccinated animals survived infection and were also protected to SARS-CoV-2 reinfection. Furthermore, two MVA-CoV2-S doses induced long-term memory S-specific humoral and cellular immune responses in C57BL/6 mice, 6 months after immunization. The efficacy and immunological benefits of the MVA-CoV2-S vaccine candidate against COVID-19 supports its consideration for human clinical trials.
Published: 2022

21. MVA-CoV2-S Vaccine Candidate Neutralizes Distinct Variants of Concern and Protects Against SARS-CoV-2 Infection in Hamsters

Author: Ministerio de Sanidad (España), Instituto de Salud Carlos III, Consejo Superior de Investigaciones Científicas (España), Fundación la Caixa, Banco Santander, Conferencia de Rectores de las Universidades Españolas, Ferrovial, Fundación Mapfre, Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), KU Leuven, European Commission, Boudewijns, Robbert, Pérez Ramírez, Patricia, Lázaro-Frías, Adrián, Van Looveren, Dominique, Vercruysse, Thomas, Thibaut, Hendrik Jan, Weynand, Birgit, Coelmont, Lotte, Neyts, Johan, Astorgano, David, Montenegro, Dolores, Puentes, Eugenia, Rodríguez, Esteban, Dallmeier, Kai, Esteban, Mariano, García-Arriaza, Juan, Ministerio de Sanidad (España), Instituto de Salud Carlos III, Consejo Superior de Investigaciones Científicas (España), Fundación la Caixa, Banco Santander, Conferencia de Rectores de las Universidades Españolas, Ferrovial, Fundación Mapfre, Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), KU Leuven, European Commission, Boudewijns, Robbert, Pérez Ramírez, Patricia, Lázaro-Frías, Adrián, Van Looveren, Dominique, Vercruysse, Thomas, Thibaut, Hendrik Jan, Weynand, Birgit, Coelmont, Lotte, Neyts, Johan, Astorgano, David, Montenegro, Dolores, Puentes, Eugenia, Rodríguez, Esteban, Dallmeier, Kai, Esteban, Mariano, and García-Arriaza, Juan
Abstract: To control the coronavirus disease 2019 (COVID-19) pandemic and the emergence of different variants of concern (VoCs), novel vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are needed. In this study, we report the potent immunogenicity and efficacy induced in hamsters by a vaccine candidate based on a modified vaccinia virus Ankara (MVA) vector expressing a human codon optimized full-length SARS-CoV-2 spike (S) protein (MVA-S). Immunization with one or two doses of MVA-S elicited high titers of S- and receptor-binding domain (RBD)-binding IgG antibodies and neutralizing antibodies against parental SARS-CoV-2 and VoC alpha, beta, gamma, delta, and omicron. After SARS-CoV-2 challenge, MVA-S-vaccinated hamsters showed a significantly strong reduction of viral RNA and infectious virus in the lungs compared to the MVA-WT control group. Moreover, a marked reduction in lung histopathology was also observed in MVA-S-vaccinated hamsters. These results favor the use of MVA-S as a potential vaccine candidate for SARS-CoV-2 in clinical trials.
Published: 2022

22. Striatal Blood-Brain Barrier Opening in Parkinson's Disease Dementia: A Pilot Exploratory Study

Author: Fundación Mapfre, Agencia Estatal de Investigación (España), Pineda-Pardo, José A., Gasca-Salas, Carmen, Fernández-Rodríguez, Beatriz, Rodríguez-Rojas, Rafael, Álamo, Marta del, Obeso, Ignacio, Hernández-Fernández, Frida, Trompeta, Clara, Martínez-Fernández, Raúl, Matarazzo, Michele, Mata-Marín, David, Guida, Pasqualina, Duque, Alicia, Albillo, David, Plaza de Las Heras, Isabel, Montero, Juan I., Foffani, Guglielmo, Toltsis, Gabriella, Rachmilevitch, Itay, Blesa, Javier, Obeso, José A., Fundación Mapfre, Agencia Estatal de Investigación (España), Pineda-Pardo, José A., Gasca-Salas, Carmen, Fernández-Rodríguez, Beatriz, Rodríguez-Rojas, Rafael, Álamo, Marta del, Obeso, Ignacio, Hernández-Fernández, Frida, Trompeta, Clara, Martínez-Fernández, Raúl, Matarazzo, Michele, Mata-Marín, David, Guida, Pasqualina, Duque, Alicia, Albillo, David, Plaza de Las Heras, Isabel, Montero, Juan I., Foffani, Guglielmo, Toltsis, Gabriella, Rachmilevitch, Itay, Blesa, Javier, and Obeso, José A.
Abstract: Parkinson's disease (PD) exhibits a high prevalence of dementia as disease severity and duration progress. Focused ultrasound (FUS) has been applied for transient blood-brain barrier (BBB) opening of cortical regions in neurodegenerative disorders. The striatum is a primary target for delivery of putative therapeutic agents in PD.
Published: 2022

23. Introducción a las fuentes etnográficas y la América indígena

Author: Andrés-Gallego, José, 1944-, Director Coordinador, Fundación Ignacio Larramendi, Editor, Digibis, S.L., Productor, Fundación MAPFRE América, Editor, Fundación MAPFRE América, Andrés-Gallego, José, 1944-, Director Coordinador, Fundación Ignacio Larramendi, Editor, Digibis, S.L., Productor, Fundación MAPFRE América, Editor, and Fundación MAPFRE América
Published: 2019

24. Esquimales

Author: Esteva Fabregat, Claudio, 1918-2017, Director de la colección, Andrés-Gallego, José, 1944-, Director Coordinador, Fundación Ignacio Larramendi, Editor, Digibis, S.L., Productor, Fundación MAPFRE América, Editor, Hernando de Larramendi Martínez, Ramón, 1965, Fundación MAPFRE América, Esteva Fabregat, Claudio, 1918-2017, Director de la colección, Andrés-Gallego, José, 1944-, Director Coordinador, Fundación Ignacio Larramendi, Editor, Digibis, S.L., Productor, Fundación MAPFRE América, Editor, Hernando de Larramendi Martínez, Ramón, 1965, and Fundación MAPFRE América
Published: 2019

25. The role of medicine in the growing expectation of healthy life of the population

Author: Antonio Huertas-Mejías and Presidente de Fundación Mapfre
Subjects: education.field_of_study, business.industry, Population, Medicine, General Medicine, education, business, Demography
Published: 2019

26. COVID-19 vaccine candidates based on modified vaccinia virus Ankara expressing the SARS-CoV-2 spike induce robust T- and B-cell immune responses and full efficacy in mice

Author: Ministerio de Sanidad, Consumo y Bienestar Social (España), Instituto de Salud Carlos III, Banco Santander, Conferencia de Rectores de las Universidades Españolas, Consejo Superior de Investigaciones Científicas (España), Ferrovial, Fundación Mapfre, European Commission, García-Arriaza, Juan, Garaigorta, Urtzi, Pérez Ramírez, Patricia, Lázaro-Frías, Adrián, Zamora, Carmen, Gastaminza, Pablo, Fresno, Carlos del, Casasnovas, José María, Sorzano, Carlos Óscar S., Sancho, David, Esteban, Mariano, Ministerio de Sanidad, Consumo y Bienestar Social (España), Instituto de Salud Carlos III, Banco Santander, Conferencia de Rectores de las Universidades Españolas, Consejo Superior de Investigaciones Científicas (España), Ferrovial, Fundación Mapfre, European Commission, García-Arriaza, Juan, Garaigorta, Urtzi, Pérez Ramírez, Patricia, Lázaro-Frías, Adrián, Zamora, Carmen, Gastaminza, Pablo, Fresno, Carlos del, Casasnovas, José María, Sorzano, Carlos Óscar S., Sancho, David, and Esteban, Mariano
Abstract: Vaccines against SARS-CoV-2, the causative agent of the COVID-19 pandemic, are urgently needed. We developed two COVID-19 vaccines based on modified vaccinia virus Ankara (MVA) vectors expressing the entire SARS-CoV-2 spike (S) protein (MVA-CoV2-S); their immunogenicity was evaluated in mice using DNA/MVA or MVA/MVA prime/boost immunizations. Both vaccines induced robust, broad and polyfunctional S-specific CD4+ (mainly Th1) and CD8+ T-cell responses, with a T effector memory phenotype. DNA/MVA immunizations elicited higher T-cell responses. All vaccine regimens triggered high titers of IgG antibodies specific for the S, as well as for the receptor-binding domain; the predominance of the IgG2c isotype was indicative of Th1 immunity. Notably, serum samples from vaccinated mice neutralized SARS-CoV-2 in cell cultures, and those from MVA/MVA immunizations showed a higher neutralizing capacity. Remarkably, one or two doses of MVA-CoV2-S protect humanized K18-hACE2 mice from a lethal dose of SARS-CoV-2. In addition, two doses of MVA-CoV2-S confer full inhibition of virus replication in the lungs. These results demonstrate the robust immunogenicity and full efficacy of MVA-based COVID-19 vaccines in animal models and support its translation to the clinic.
Published: 2021

27. Colecciones MAPFRE 1492 500 años, América hacia el futuro

Author: Andrés-Gallego, José, 1944-, Director Coordinador, Fundación Ignacio Larramendi, Editor, Digibis, S.L., Productor, Fundación MAPFRE América, Editor, Fundación MAPFRE América, Andrés-Gallego, José, 1944-, Director Coordinador, Fundación Ignacio Larramendi, Editor, Digibis, S.L., Productor, Fundación MAPFRE América, Editor, and Fundación MAPFRE América
Published: 2018

28. Impact of Life's Simple 7 on the incidence of major cardiovascular events in high-risk Spanish adults in the PREDIMED study cohort

Author: Instituto de Salud Carlos III, Ministerio de Sanidad, Servicios Sociales e Igualdad (España), Centro Nacional de Investigaciones Cardiovasculares (España), European Commission, Ministerio de Ciencia e Innovación (España), Fundación Mapfre, Junta de Andalucía, Generalitat de Catalunya, Generalitat Valenciana, Diputación Foral de Navarra, Díez-Espino, Javier, Buil-Cosiales, Pilar, Babio, Nancy, Toledo, Estefania, Corella, Dolores, Ros, Emilio, Fitó, Montserrat, Gómez-Gracia, Enrique, Estruch, Ramón, Fiol, Miquel, Lapetra, José, Alonso-Gómez, Ángel M., Serra-Majem, Lluis, Pintó, Xavier, Sorlí, José V., Muñoz, Miguel Ángel, Basora, Josep, Martínez-González, Miguel Ángel, Instituto de Salud Carlos III, Ministerio de Sanidad, Servicios Sociales e Igualdad (España), Centro Nacional de Investigaciones Cardiovasculares (España), European Commission, Ministerio de Ciencia e Innovación (España), Fundación Mapfre, Junta de Andalucía, Generalitat de Catalunya, Generalitat Valenciana, Diputación Foral de Navarra, Díez-Espino, Javier, Buil-Cosiales, Pilar, Babio, Nancy, Toledo, Estefania, Corella, Dolores, Ros, Emilio, Fitó, Montserrat, Gómez-Gracia, Enrique, Estruch, Ramón, Fiol, Miquel, Lapetra, José, Alonso-Gómez, Ángel M., Serra-Majem, Lluis, Pintó, Xavier, Sorlí, José V., Muñoz, Miguel Ángel, Basora, Josep, and Martínez-González, Miguel Ángel
Abstract: [EN] Introduction and objectives The Life's Simple 7 strategy of the American Heart Association proposes 7 metrics of ideal cardiovascular health: body mass index (BMI) < 25 mg/m2, not smoking, healthy diet, moderate physical activity ≥ 150 min/wk, total blood cholesterol < 200 mg/dL, systolic and diastolic blood pressures < 120 and < 80 mmHg, respectively, and fasting blood glucose < 100 mg/dL. It is important to assess the combined effect of these 7 metrics in the Spanish population. We prospectively analyzed the impact of baseline Life's Simple 7 metrics on the incidence of major cardiovascular events in the PREDIMED cohort (57.5% women, average baseline age, 67 years). Methods The healthy diet metric was defined as attaining ≥ 9 points on a validated 14-item Mediterranean diet adherence screener. An incident major cardiovascular event was defined as a composite of myocardial infarction, stroke, or cardiovascular death. Cox regression was used to calculate multivariable adjusted hazard ratios (HR) and their 95% confidence intervals (95%CI) for successive categories of health metrics. Results After a median follow-up of 4.8 years in 7447 participants, there were 288 major cardiovascular events. After adjustment for age, sex, center, and intervention group, HRs (95%CI) were 0.73 (0.54-0.99), 0.57 (0.41-0.78), and 0.34 (0.21-0.53) for participants with 2, 3, and ≥ 4 metrics, respectively, compared with participants with only 0 to 1 metrics. Conclusions In an elderly Spanish population at high cardiovascular risk, better adherence to Life's Simple 7 metrics was progressively associated with a substantially lower rate of major cardiovascular events., [ES] Introducción y objetivos La estrategia Life's Simple 7 de la American Heart Association propuso 7 métricas de salud cardiovascular ideal: índice de masa corporal (IMC) < 25, no fumar, dieta saludable, actividad física moderada ≥ 150 min a la semana, colesterol total < 200 mg/dl, presión arterial sistólica < 120 mmHg y diastólica < 80 mmHg y glucemia basal < 100 mg/dl. Resulta de gran interés valorar el efecto combinado de estas 7 metas. Se analizó prospectivamente el impacto de las métricas basales Life's Simple 7 en la incidencia de eventos cardiovasculares mayores en la cohorte PREDIMED (el 57,5% mujeres; media de edad inicial, 67 años). Métodos La métrica de dieta saludable se definió como alcanzar al menos 9 puntos en una escala validada de 14 puntos de adhesión a dieta mediterránea. Se definió evento cardiovascular mayor incidente como infarto de miocardio, ictus o muerte de causa cardiovascular. Se usó regresión de Cox para estimar hazard ratios (HR) ajustadas multivariables con intervalos de confianza del 95% (IC95%) para categorías sucesivas de métricas de salud cardiovascular. Resultados Tras seguir a 7.447 participantes durante una mediana de 4,8 años, se registraron 288 eventos. Respecto a los participantes con solo 0-1 métricas, tras ajustar por edad, sexo, centro y grupo de intervención, se observaron HR (IC95%) 0,73 (0,54-0,99), 0,57 (0,41-0,78) y 0,34 (0,21-0,53), para 2, 3 y 4 o más métricas respectivamente. Conclusiones En una población española con alto riesgo cardiovascular, la presencia de un mayor número de métricas se asoció progresivamente con una reducción sustancial en la tasa de eventos cardiovasculares mayores.
Published: 2020

29. Association between the 2018 WCRF/AICR and the Low-Risk Lifestyle Scores with Colorectal Cancer Risk in the Predimed Study

Author: Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y Nutrición (España), Instituto de Salud Carlos III, European Commission, Centro Nacional de Investigaciones Cardiovasculares (España), Ministerio de Ciencia e Innovación (España), Fundación Mapfre, Junta de Andalucía, Generalitat Valenciana, Generalitat de Catalunya, Nafarroako Gobernua, Fundación Patrimonio Comunal Olivarero, Hojiblanca, Institución Catalana de Investigación y Estudios Avanzados, California Walnut Commission, Borges, Morella Nuts, Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), Ministerio de Educación, Cultura y Deporte (España), Barrubés, Laura, Babio, Nancy, Hernández-Alonso, Pablo, Toledo, Estefania, Ramírez Sabio, Judith B., Estruch, Ramón, Ros, Emilio, Fitó, Montserrat, Alonso-Gómez, Ángel M., Fiol, Miquel, Lapetra, José, Serra-Majem, Lluis, Pintó, Xavier, Ruiz-Canela, Miguel, Corella, Dolores, Macías-González, Manuel, Salas-Salvadó, Jordi, Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y Nutrición (España), Instituto de Salud Carlos III, European Commission, Centro Nacional de Investigaciones Cardiovasculares (España), Ministerio de Ciencia e Innovación (España), Fundación Mapfre, Junta de Andalucía, Generalitat Valenciana, Generalitat de Catalunya, Nafarroako Gobernua, Fundación Patrimonio Comunal Olivarero, Hojiblanca, Institución Catalana de Investigación y Estudios Avanzados, California Walnut Commission, Borges, Morella Nuts, Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), Ministerio de Educación, Cultura y Deporte (España), Barrubés, Laura, Babio, Nancy, Hernández-Alonso, Pablo, Toledo, Estefania, Ramírez Sabio, Judith B., Estruch, Ramón, Ros, Emilio, Fitó, Montserrat, Alonso-Gómez, Ángel M., Fiol, Miquel, Lapetra, José, Serra-Majem, Lluis, Pintó, Xavier, Ruiz-Canela, Miguel, Corella, Dolores, Macías-González, Manuel, and Salas-Salvadó, Jordi
Abstract: Limited longitudinal studies have been conducted to evaluate colorectal cancer (CRC) incidence based on the updated 2018 World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) recommendations or other global lifestyle indices, and none in aged populations at high cardiovascular risk. We aimed to assess the association between CRC incidence and adherence to two emerging lifestyles indices (2018 WCRF/AICR score and another low-risk lifestyle (LRL) score comprising smoking status, alcohol consumption, physical activity, diet, and body mass index) in the Spanish PREvencion con DIeta MEDiterranea (PREDIMED) cohort. We studied 7216 elderly men and women at high cardiovascular risk. The 2018 WCRF/AICR and LRL scores were calculated. Multivariable Cox proportional regression models were fitted to estimate the HRs (hazard ratios) and 95% confidence intervals (CIs) for incident CRC events. During a median interquartile range (IQR) follow-up of 6.0 (4.4–7.3) years, 97 CRC events were considered. A significant linear association was observed between each 1-point increment in the WCRF/AICR score (score range from 0 to 7) and CRC risk (HR (95% CI) = 0.79 (0.63–0.99)). Similarly, each 1-point increment in the LRL score (score range from 0 to 5) was associated with a 22% reduction in CRC risk (0.78 (0.64–0.96)). Adhering to emergent lifestyle scores might substantially reduce CRC incidence in elderly individuals. Further longitudinal studies, which take different lifestyle indexes into account, are warranted in the future.
Published: 2020

30. Key factors controlling microbial community responses after a fire: Importance of severity and recurrence

Author: Ministerio de Economía y Competitividad (España), CSIC - Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA), European Commission, Fundación Mapfre, Ministerio de Educación (España), Lombao, Alba, Barreiro, Ana, Fontúrbel Lliteras, Mª Teresa, Martín Jiménez, Ángela, Carballas, Tarsy, Díaz-Raviña, Montserrat, Ministerio de Economía y Competitividad (España), CSIC - Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA), European Commission, Fundación Mapfre, Ministerio de Educación (España), Lombao, Alba, Barreiro, Ana, Fontúrbel Lliteras, Mª Teresa, Martín Jiménez, Ángela, Carballas, Tarsy, and Díaz-Raviña, Montserrat
Abstract: Wildfires are a major problem in Mediterranean forest ecosystems, affecting the same area year after year. Their severity is increasing, partly due to climate change and hence, every now and then, virulent fires of high severity spread ravage this region. The aim of this study was to evaluate the influence of fire regime (recurrence, severity) in soil microbial community structure analyzing the phospholipid fatty acid (PLFA) and the microbial functional diversity assessing the level physiological profiling technique (CLPP). Samples of a soil affected by a high severities wildfire and a soil affected by a low severity experimental fire were heated under laboratory conditions at different temperatures to simulate different fire severity. To simulate fire recurrence, the heating treatment was repeated after one month of incubation. The fire severity was estimated as the amount of heat supplied to samples by degree-hour methodology. A marked impact of fire regime on soil microorganisms was detected; the microbial community response varied depending on previous history of fire and the magnitude of changes in PLFA pattern and CLPP, was related to the amount of heat supplied to the samples. Wildfires had a greater impact on microbial community structure than subsequent soil heating in the laboratory. The total biomass and the biomass of specific groups of microorganisms decreased notably as a consequence of wildfire and minor changes were detected due to the experimental fire and soil heating under laboratory conditions. The results clearly showed the usefulness of PLFA pattern to study the effect of fire regimes and associated direct and indirect changes in soil microorganisms and in soil quality. The data also indicated that the degree-hour methodology rather than maximum temperature is adequate to simulate fire severity and evaluate the impact of thermal shock on soil ecosystems.
Published: 2020

31. Soil Heating at High Temperatures and Different Water Content: Effects on the Soil Microorganisms

Author: Ministerio de Economía y Competitividad (España), Fundación Mapfre, Ministerio de Educación (España), Barreiro, Ana, Lombao, Alba, Martín Jiménez, Ángela, Cancelo-González, J., Carballas, Tarsy, Díaz-Raviña, Montserrat, Ministerio de Economía y Competitividad (España), Fundación Mapfre, Ministerio de Educación (España), Barreiro, Ana, Lombao, Alba, Martín Jiménez, Ángela, Cancelo-González, J., Carballas, Tarsy, and Díaz-Raviña, Montserrat
Abstract: Soil properties determining the thermal transmissivity, the heat duration and temperatures reached during soil heating are key factors driving the fire-induced changes in soil microbial communities. The aim of the present study is to analyze, under laboratory conditions, the impact of the thermal shock (infrared lamps reaching temperatures of 100 °C, 200 °C and 400 °C) and moisture level (0%, 25% and 50% per soil volume) on the microbial properties of three soil mixtures from different sites. The results demonstrated that the initial water content was a determinant factor in the response of the microbial communities to soil heating treatments. Measures of fire impact included intensity and severity (temperature, duration), using the degree-hours method. Heating temperatures produced varying thermal shock and impacts on biomass, bacterial activity and microbial community structure.
Published: 2020

32. La obesidad puede promover la aparición de cepas virulentas del SARS-COV-2 : Implicaciones para tratamientos y estrategias de vacunación

Author: Fundación MAPFRE, Editor, Arbonés Mainar, José Miguel, autor, Fundación MAPFRE, Editor, and Arbonés Mainar, José Miguel, autor
Abstract: Premios: Ayudas a la Investidación Ignacio Larramendi, 2020-2020
Published: 2020

33. Proyecto PsiCOPvid, evaluación del Programa de Atención Psicológica Telefónica desarrollado durante la crisis del COVID-19

Author: Fundación MAPFRE, Editor, Muñoz Navarro, Roger, autor, Fundación MAPFRE, Editor, and Muñoz Navarro, Roger, autor
Abstract: Premios: Ayudas a la Investidación Ignacio Larramendi, 2020-2020
Published: 2020

34. Análisis y perfil genético de marcadores metabólicos, función cardiorrespiratoria y muscular, y su asociación con el riesgo de obesidad y lesión en deportistas profesionales, ecaliación durante la pandemia COVID19

Author: Fundación MAPFRE, Editor, Varillas Delgado, David, autor, Fundación MAPFRE, Editor, and Varillas Delgado, David, autor
Abstract: Premios: Ayudas a la Investidación Ignacio Larramendi, 2020-2020
Published: 2020

35. El sueño y el teletrabajo en tiempos de Covid

Author: Fundación MAPFRE, Editor, Estivill Domènech, Carla, autor, Fundación MAPFRE, Editor, and Estivill Domènech, Carla, autor
Abstract: Premios: Ayudas a la Investidación Ignacio Larramendi, 2020-2020
Published: 2020

36. Análisis del patrón de marcha mediante el diseño de un prototipo electrónico y una app de monitorización (G_STRIDE)

Author: Fundación MAPFRE, Editor, Rodríguez Sánchez, Cristina, autor, Fundación MAPFRE, Editor, and Rodríguez Sánchez, Cristina, autor
Abstract: Premios: Ayudas a la Investidación Ignacio Larramendi, 2020-2020
Published: 2020

37. Manejo de la obesidad infantil en el contexto de la atención primaria de salud : un enfoque basado en la intervención intensiva de componentes múltiples

Author: Fundación MAPFRE, Editor, Mendes, Larissa Loures, autor, Fundación MAPFRE, Editor, and Mendes, Larissa Loures, autor
Abstract: Premios: Ayudas a la Investidación Ignacio Larramendi, 2020-2020
Published: 2020

38. Sexting durante la pandemia Covid-19 : hacia un paradigma educativo basado en evidencias

Author: Fundación MAPFRE, Editor, Gómez Durán, Esperanza, autor, Fundación MAPFRE, Editor, and Gómez Durán, Esperanza, autor
Abstract: Premios: Ayudas a la Investidación Ignacio Larramendi, 2020-2020
Published: 2020

39. Randomized Trial of Focused Ultrasound Subthalamotomy for Parkinson's Disease

Author: Fundación HM Hospitales, Focused Ultrasound Foundation, Fundación Mapfre, Insightec, University of Virginia, Martínez-Fernández, Raúl, Máñez-Miró, Jorge U., Rodríguez-Rojas, Rafael, Álamo, Marta del, Shah, Binit B., Hernández-Fernández, Frida, Pineda-Pardo, José A., Monje, Mariana H. G., Fernández-Rodríguez, Beatriz, Sperling, Scott A., Mata-Marín, David, Guida, Pasqualina, Alonso-Frech, Fernando, Obeso, Ignacio, Gasca-Salas, Carmen, Vela-Desojo, Lydia, Elias, W Jeffrey, Obeso, José A., Fundación HM Hospitales, Focused Ultrasound Foundation, Fundación Mapfre, Insightec, University of Virginia, Martínez-Fernández, Raúl, Máñez-Miró, Jorge U., Rodríguez-Rojas, Rafael, Álamo, Marta del, Shah, Binit B., Hernández-Fernández, Frida, Pineda-Pardo, José A., Monje, Mariana H. G., Fernández-Rodríguez, Beatriz, Sperling, Scott A., Mata-Marín, David, Guida, Pasqualina, Alonso-Frech, Fernando, Obeso, Ignacio, Gasca-Salas, Carmen, Vela-Desojo, Lydia, Elias, W Jeffrey, and Obeso, José A.
Abstract: The subthalamic nucleus is the preferred neurosurgical target for deep-brain stimulation to treat cardinal motor features of Parkinson's disease. Focused ultrasound is an imaging-guided method for creating therapeutic lesions in deep-brain structures, including the subthalamic nucleus.
Published: 2020

40. La creación literaria en lengua sefardí

Author: Andrés-Gallego, José, 1944-, Director Coordinador, Fundación Ignacio Larramendi, Editor, Digibis, S.L., Productor, Fundación MAPFRE América, Editor, Fundación MAPFRE América, Andrés-Gallego, José, 1944-, Director Coordinador, Fundación Ignacio Larramendi, Editor, Digibis, S.L., Productor, Fundación MAPFRE América, Editor, and Fundación MAPFRE América
Published: 2017

41. Últimos reductos españoles en América

Author: Andrés-Gallego, José, 1944-, Director Coordinador, Fundación Ignacio Larramendi, Editor, Digibis, S.L., Productor, Fundación MAPFRE América, Editor, Fundación MAPFRE América, Andrés-Gallego, José, 1944-, Director Coordinador, Fundación Ignacio Larramendi, Editor, Digibis, S.L., Productor, Fundación MAPFRE América, Editor, and Fundación MAPFRE América
Published: 2017

42. España en Nuevo México

Author: Cutter, Andrea, Traductor, Gannon, Michael, 1927-2017, Director de la colección, Lyon, Eugene, 1929-, Director de la colección, Andrés-Gallego, José, 1944-, Director Coordinador, Fundación Ignacio Larramendi, Editor, Digibis, S.L., Productor, Fundación MAPFRE América, Editor, Fundación MAPFRE América, Cutter, Andrea, Traductor, Gannon, Michael, 1927-2017, Director de la colección, Lyon, Eugene, 1929-, Director de la colección, Andrés-Gallego, José, 1944-, Director Coordinador, Fundación Ignacio Larramendi, Editor, Digibis, S.L., Productor, Fundación MAPFRE América, Editor, and Fundación MAPFRE América
Published: 2017

43. La independencia de Chile : tradición, modernización y mito

Author: Andrés-Gallego, José, 1944-, Director Coordinador, Fundación Ignacio Larramendi, Editor, Digibis, S.L., Productor, Fundación MAPFRE América, Editor, Fundación MAPFRE América, Andrés-Gallego, José, 1944-, Director Coordinador, Fundación Ignacio Larramendi, Editor, Digibis, S.L., Productor, Fundación MAPFRE América, Editor, and Fundación MAPFRE América
Published: 2017

44. Los indios de Colombia

Author: Morales G., Jorge, Autor, Calle Restrepo, Horacio, Autor, Esteva Fabregat, Claudio, 1918-2017, Director de la colección, Andrés-Gallego, José, 1944-, Director Coordinador, Fundación Ignacio Larramendi, Editor, Digibis, S.L., Productor, Fundación MAPFRE América, Editor, Fundación MAPFRE América, Morales G., Jorge, Autor, Calle Restrepo, Horacio, Autor, Esteva Fabregat, Claudio, 1918-2017, Director de la colección, Andrés-Gallego, José, 1944-, Director Coordinador, Fundación Ignacio Larramendi, Editor, Digibis, S.L., Productor, Fundación MAPFRE América, Editor, and Fundación MAPFRE América
Published: 2017

45. El Brasil filipino : 60 años de presencia española en brasil (1580-1640)

Author: Andrés-Gallego, José, 1944-, Director Coordinador, Fundación Ignacio Larramendi, Editor, Digibis, S.L., Productor, Fundación MAPFRE América, Editor, Fundación MAPFRE América, Andrés-Gallego, José, 1944-, Director Coordinador, Fundación Ignacio Larramendi, Editor, Digibis, S.L., Productor, Fundación MAPFRE América, Editor, and Fundación MAPFRE América
Published: 2017

46. Literatura hispanoárabe

Author: Andrés-Gallego, José, 1944-, Director Coordinador, Fundación Ignacio Larramendi, Editor, Digibis, S.L., Productor, Fundación MAPFRE América, Editor, Fundación MAPFRE América, Andrés-Gallego, José, 1944-, Director Coordinador, Fundación Ignacio Larramendi, Editor, Digibis, S.L., Productor, Fundación MAPFRE América, Editor, and Fundación MAPFRE América
Published: 2017

47. La expulsión de los judíos de España

Author: Andrés-Gallego, José, 1944-, Director Coordinador, Fundación Ignacio Larramendi, Editor, Digibis, S.L., Productor, Fundación MAPFRE América, Editor, Fundación MAPFRE América, Andrés-Gallego, José, 1944-, Director Coordinador, Fundación Ignacio Larramendi, Editor, Digibis, S.L., Productor, Fundación MAPFRE América, Editor, and Fundación MAPFRE América
Published: 2017

48. Polémica y convivencia de las tres religiones

Author: Andrés-Gallego, José, 1944-, Director Coordinador, Hernando de Larramendi Martínez, Margarita, 1960-, Traductor, Fundación Ignacio Larramendi, Editor, Digibis, S.L., Productor, Fundación MAPFRE América, Editor, Fundación MAPFRE América, Andrés-Gallego, José, 1944-, Director Coordinador, Hernando de Larramendi Martínez, Margarita, 1960-, Traductor, Fundación Ignacio Larramendi, Editor, Digibis, S.L., Productor, Fundación MAPFRE América, Editor, and Fundación MAPFRE América
Published: 2017

49. La ciencia hispanojudía

Author: Andrés-Gallego, José, 1944-, Director Coordinador, Fundación Ignacio Larramendi, Editor, Digibis, S.L., Productor, Fundación MAPFRE América, Editor, Fundación MAPFRE América, Andrés-Gallego, José, 1944-, Director Coordinador, Fundación Ignacio Larramendi, Editor, Digibis, S.L., Productor, Fundación MAPFRE América, Editor, and Fundación MAPFRE América
Published: 2017

50. Diáspora sefardí

Author: Bel Bravo, María Antonia, Coordinadora, Kaplan, Yosef, Autor, Barnai, Jacob, Autor, Landau, Jacob M., Autor, Leibovici, Sarah, Autor, Vilar, Juan Bautista, 1941-2018, Autor, Andrés-Gallego, José, 1944-, Director Coordinador, Fundación Ignacio Larramendi, Editor, Digibis, S.L., Productor, Fundación MAPFRE América, Editor, Fundación MAPFRE América, Bel Bravo, María Antonia, Coordinadora, Kaplan, Yosef, Autor, Barnai, Jacob, Autor, Landau, Jacob M., Autor, Leibovici, Sarah, Autor, Vilar, Juan Bautista, 1941-2018, Autor, Andrés-Gallego, José, 1944-, Director Coordinador, Fundación Ignacio Larramendi, Editor, Digibis, S.L., Productor, Fundación MAPFRE América, Editor, and Fundación MAPFRE América
Published: 2017

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