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12. Abstract P2-15-12: Effect of Bevacizumab and Eribulin for metastatic breast cancer in the real world evaluated using the propensity score matching analysis (PSMA) and inverse probability of treatment weighting analysis (IPTWA)

Author

Matsui, Koshi, primary, Earashi, Mitsuharu, additional, Nagata, Takuya, additional, Yoshikawa, Akemi, additional, Fukushima, Wataru, additional, Nozaki, Zensei, additional, Tanada, Yasuko, additional, Oyama, Kaeko, additional, Shimada, Katsuo, additional, Kiyohara, Kaoru, additional, Shimizu, Tetsuro, additional, Iwata, Keiko, additional, Yoshida, Toru, additional, Maeda, Kiichi, additional, Nakakura, Akiyoshi, additional, Morita, Satoshi, additional, and Fujii, Tsutomu, additional

Published
2020
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15. Extract of curry powder and its components protect against diesel exhaust particle-induced inflammatory responses in human airway epithelial cells

Author

Honda, Akiko, primary, Ito, Sho, additional, Tanaka, Michitaka, additional, Sawahara, Takahiro, additional, Hayashi, Tomohiro, additional, Fukushima, Wataru, additional, Kitamura, Gaku, additional, Kudo, Hitomi, additional, Chowdhury, Pratiti Home, additional, Okano, Hitoshi, additional, Onishi, Toshinori, additional, Kawaryu, Yusuke, additional, Higashihara, Makoto, additional, Nakayama, Hideki, additional, Ueda, Kayo, additional, and Takano, Hirohisa, additional

Published
2019
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17. Synergistic effect of carbon nuclei and polyaromatic hydrocarbons on respiratory and immune responses

Author

Chowdhury, Pratiti H., Kitamura, Gaku, Honda, Akiko, Sawahara, Takahiro, Hayashi, Tomohiro, Fukushima, Wataru, Kudo, Hitomi, Ito, Sho, Yoshida, Seiichi, Ichinose, Takamichi, Ueda, Kayo, and Takano, Hirohisa

Subjects
antigen‐presenting cell, respiratory health, polyaromatic hydrocarbon, Antigen-Presenting Cells, Bone Marrow Cells, Epithelial Cells, Respiratory Mucosa, Phenanthrenes, complex mixtures, immune response, Carbon, Mice, Benzo(a)pyrene, Animals, Cytokines, Humans, Particulate Matter, Lymphocytes, Polycyclic Aromatic Hydrocarbons, Spleen, Naphthoquinones, Vehicle Emissions
Abstract

Particulate matter with aerodynamic diameter ≤2.5 μm (PM₂.₅) is generally composed of carbon nuclei associated with various organic carbons, metals, ions and biological materials. Among these components, polyaromatic hydrocarbons (PAHs) such as benzo(a)pyrene (BaP) and quinones have detrimental effects on airway epithelial cells and immunodisrupting effects, which leads to the exacerbation of respiratory allergies. The effects of PAHs and the carbon nuclei, separately as well as in combination, remain to be established. We investigated the effects of BaP, 9, 10‐phenanthroquinone (9, 10‐PQ), and 1, 2‐napthoquinone (1, 2‐NQ) and their combined effects with heated diesel exhaust particle (H‐DEP) as carbon nuclei of typical PM₂.₅. We exposed human airway epithelial cells (BEAS‐2B), murine bone marrow‐derived antigen‐presenting cells (APCs), and murine splenocytes to BaP, 9, 10‐PQ, or 1, 2‐NQ in the presence and absence of H‐DEP. Several important inflammatory cytokines and cell surface molecules were measured. PAHs alone did not have apparent cytotoxic effects on BEAS‐2B, whereas combined exposure with H‐DEP induced noticeable detrimental effects which mainly reflected the action of H‐DEP itself. BaP increased CD86 expression as an APC surface molecule regardless of the presence or absence of H‐DEP. None of the BaP, 9, 10‐PQ, or 1, 2‐NQ exposure alone or their combined exposure with H‐DEP resulted in any significant activation of splenocytes. These results suggest that PAHs and carbon nuclei show additive effects, and that BaP with the carbon nuclei may contribute to exacerbations of allergic respiratory diseases including asthma by PM₂.₅, especially via antigen‐presenting cell activation.

Published
2016

18. Biological factor related to Asian sand dust particles contributes to the exacerbation of asthma

Author

Honda, Akiko, Sawahara, Takahiro, Hayashi, Tomohiro, Tsuji, Kenshi, Fukushima, Wataru, Oishi, Mizuki, Kitamura, Gaku, Kudo, Hitomi, Ito, Sho, Yoshida, Seiichi, Ichinose, Takamichi, Ueda, Kayo, and Takano, Hirohisa

Subjects
Male, bone‐marrow‐derived antigen presenting cells, Asia, Antigen-Presenting Cells, Dust, Epithelial Cells, Silicon Dioxide, behavioral disciplines and activities, Asthma, Asian sand dust particles, Mice, mental disorders, Benzo(a)pyrene, Animals, Cytokines, Humans, Bjerkandera adusta, Polycyclic Aromatic Hydrocarbons, Coriolaceae, Spleen, Cell Proliferation
Abstract

Epidemiologic studies have revealed that Asian sand dust particles (ASDs) can affect respiratory and immune health represented by asthma. Factors responsible for the exacerbation of asthma remain unclear. The fungus Bjerkandera adusta (B.ad) and polycyclic aromatic hydrocarbons such as benzo[a]pyrene (BaP) have been identified in ASDs collected from the atmosphere when an ASD event occurred. We investigated the effects of B.ad and BaP related to ASDs on respiratory and immune systems. Bone marrow-derived antigen-presenting cells (APCs) and splenocytes from atopic prone NC/Nga mice and human airway epithelial cells were exposed to the B.ad or to BaP in the presence and absence of heated-ASDs (H-ASDs). B.ad and BaP in both the presence and absence of H-ASDs increased the expression of cell surface molecules on APCs. H-ASDs alone slightly activated APCs. The expressions induced by B.ad were higher than those induced by BaP in the presence and absence of H-ASDs. There were no remarkable effects on the activation of splenocytes or the proinflammatory responses in airway epithelial cells. These results suggest that B.ad rather than BaP contributes to the exacerbation of asthma regardless of the presence or absence of sand particles, particularly by the activation of the immune system via APCs. Copyright © 2016 John WileySons, Ltd.

Published
2016

19. Synergistic effect of carbon nuclei and polyaromatic hydrocarbons on respiratory and immune responses

Author

Chowdhury, Pratiti H., primary, Kitamura, Gaku, additional, Honda, Akiko, additional, Sawahara, Takahiro, additional, Hayashi, Tomohiro, additional, Fukushima, Wataru, additional, Kudo, Hitomi, additional, Ito, Sho, additional, Yoshida, Seiichi, additional, Ichinose, Takamichi, additional, Ueda, Kayo, additional, and Takano, Hirohisa, additional

Published
2017
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20. Biological factor related to Asian sand dust particles contributes to the exacerbation of asthma

Author

20454324, 60444717, 60281698, Honda, Akiko, Sawahara, Takahiro, Hayashi, Tomohiro, Tsuji, Kenshi, Fukushima, Wataru, Oishi, Mizuki, Kitamura, Gaku, Kudo, Hitomi, Ito, Sho, Yoshida, Seiichi, Ichinose, Takamichi, Ueda, Kayo, Takano, Hirohisa, 20454324, 60444717, 60281698, Honda, Akiko, Sawahara, Takahiro, Hayashi, Tomohiro, Tsuji, Kenshi, Fukushima, Wataru, Oishi, Mizuki, Kitamura, Gaku, Kudo, Hitomi, Ito, Sho, Yoshida, Seiichi, Ichinose, Takamichi, Ueda, Kayo, and Takano, Hirohisa

Abstract

Epidemiologic studies have revealed that Asian sand dust particles (ASDs) can affect respiratory and immune health represented by asthma. Factors responsible for the exacerbation of asthma remain unclear. The fungus Bjerkandera adusta (B.ad) and polycyclic aromatic hydrocarbons such as benzo[a]pyrene (BaP) have been identified in ASDs collected from the atmosphere when an ASD event occurred. We investigated the effects of B.ad and BaP related to ASDs on respiratory and immune systems. Bone marrow‐derived antigen‐presenting cells (APCs) and splenocytes from atopic prone NC/Nga mice and human airway epithelial cells were exposed to the B.ad or to BaP in the presence and absence of heated‐ASDs (H‐ASDs). B.ad and BaP in both the presence and absence of H‐ASDs increased the expression of cell surface molecules on APCs. H‐ASDs alone slightly activated APCs. The expressions induced by B.ad were higher than those induced by BaP in the presence and absence of H‐ASDs. There were no remarkable effects on the activation of splenocytes or the proinflammatory responses in airway epithelial cells. These results suggest that B.ad rather than BaP contributes to the exacerbation of asthma regardless of the presence or absence of sand particles, particularly by the activation of the immune system via APCs.

Published
2017

21. Synergistic effect of carbon nuclei and polyaromatic hydrocarbons on respiratory and immune responses

Author

20454324, 60444717, 60281698, Chowdhury, Pratiti H., Kitamura, Gaku, Honda, Akiko, Sawahara, Takahiro, Hayashi, Tomohiro, Fukushima, Wataru, Kudo, Hitomi, Ito, Sho, Yoshida, Seiichi, Ichinose, Takamichi, Ueda, Kayo, Takano, Hirohisa, 20454324, 60444717, 60281698, Chowdhury, Pratiti H., Kitamura, Gaku, Honda, Akiko, Sawahara, Takahiro, Hayashi, Tomohiro, Fukushima, Wataru, Kudo, Hitomi, Ito, Sho, Yoshida, Seiichi, Ichinose, Takamichi, Ueda, Kayo, and Takano, Hirohisa

Published
2017

29. Biological factor related to Asian sand dust particles contributes to the exacerbation of asthma.

Author

Honda, Akiko, Sawahara, Takahiro, Hayashi, Tomohiro, Tsuji, Kenshi, Fukushima, Wataru, Oishi, Mizuki, Kitamura, Gaku, Kudo, Hitomi, Ito, Sho, Yoshida, Seiichi, Ichinose, Takamichi, Ueda, Kayo, and Takano, Hirohisa

Subjects
DISEASE exacerbation, ASTHMA treatment, POLYCYCLIC aromatic hydrocarbon analysis, DUST storms & the environment, EPITHELIAL cells, DISEASES
Abstract

Epidemiologic studies have revealed that Asian sand dust particles (ASDs) can affect respiratory and immune health represented by asthma. Factors responsible for the exacerbation of asthma remain unclear. The fungus Bjerkandera adusta ( B.ad) and polycyclic aromatic hydrocarbons such as benzo[ a]pyrene (BaP) have been identified in ASDs collected from the atmosphere when an ASD event occurred. We investigated the effects of B.ad and BaP related to ASDs on respiratory and immune systems. Bone marrow-derived antigen-presenting cells (APCs) and splenocytes from atopic prone NC/Nga mice and human airway epithelial cells were exposed to the B.ad or to BaP in the presence and absence of heated-ASDs (H-ASDs). B.ad and BaP in both the presence and absence of H-ASDs increased the expression of cell surface molecules on APCs. H-ASDs alone slightly activated APCs. The expressions induced by B.ad were higher than those induced by BaP in the presence and absence of H-ASDs. There were no remarkable effects on the activation of splenocytes or the proinflammatory responses in airway epithelial cells. These results suggest that B.ad rather than BaP contributes to the exacerbation of asthma regardless of the presence or absence of sand particles, particularly by the activation of the immune system via APCs. Copyright © 2016 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]

Published
2017
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30. Effects of Components of PM2.5 Collected in Japan on the Respiratory and Immune Systems.

Author

Honda, Akiko, Fukushima, Wataru, Tsuji, Kenshi, Hayashi, Tomohiro, Kashima, Yuji, Takahashi, Katsuyuki, and Ueda, Kayo

Subjects
*IMMUNE system, *PARTICULATE matter, *RESPIRATORY diseases, *DISEASE exacerbation, *EPITHELIAL cells
Abstract

Epidemiologic studies have reported that particulate matter with aerodynamic diameters ≤2.5 mm (PM2.5) affect respiratory diseases, including asthma. The components and/or factors of PM2.5 that contribute to the exacerbation of asthma have not been identified. We investigated the effects of extracts of PM2.5 collected in Japan on the respiratory and immune systems. PM2.5 was collected from an industrial area and an urban area in December 2013. Airway epithelial cells and immune cells were exposed to aqueous or organic extracts of PM2.5. Exposure to extracts from both areas, especially to organic extracts rather than aqueous extracts, caused a pro-inflammatory response via interleukin (IL) 6 production from airway epithelial cells, and it induced the maturation/activation of bone marrow-derived antigen-presenting cells via dendritic and epithelial cell (DEC) 205 and cluster of differentiation (CD) 86 expression and proportional changes in the constitution of the splenocytes. The extracts collected from the industrial area tended to show greater effects than those from the urban area. These results suggest that organic components of PM2.5 affect the respiratory and immune systems. These effects can differ by the collection areas. In addition, IL-6, DEC205, and CD86 can be predictive biomarkers for the respiratory and immune effects of ambient PM2.5. [ABSTRACT FROM AUTHOR]

Published
2017
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31. Effects of hydrogen peroxide on mucociliary transport in human airway epithelial cells.

Author

20454324, 60281698, Honda, Akiko, Murayama, Rumiko, Matsuda, Yugo, Tsuji, Kenshi, Sawahara, Takahiro, Fukushima, Wataru, Hayashi, Tomohiro, Shimada, Akinori, Takano, Hirohisa, 20454324, 60281698, Honda, Akiko, Murayama, Rumiko, Matsuda, Yugo, Tsuji, Kenshi, Sawahara, Takahiro, Fukushima, Wataru, Hayashi, Tomohiro, Shimada, Akinori, and Takano, Hirohisa

Abstract

The effects of environmental pollutants on airway clearance have not been well elucidated. This study examined mucociliary transport using different sized-fluorescent particles on polarized human airway epithelial cells which were maintained in an air-liquid interface (ALI) culture system. The effects of hydrogen peroxide (H2O2) exposure on mucociliary transport were also investigated. The movement of fluorescent particles with diameters of 10-14 and 2.5-4.5 µm was observed by fluorescent microscopy as an index of the mucociliary transport. The mixture of the particles with two different sizes was propelled concentrically on the apical surface by the interaction of ciliary activity and mucus in the control condition, whereas H2O2 exposure for 24 h significantly inhibited the movement of the particles. The particle sizes did not affect their movement after the control or H2O2 exposure. These results suggest that particle tracking on polarized human airway epithelial cells is a useful experimental tool for the evaluation of the effect of environmental pollutants on mucociliary transport. In addition, reactive oxygen species may impair mucociliary transport, leading to the airway damage and exacerbation of respiratory diseases.

Published
2014

36. A Case of Giant Rectal Cancer with Rhabdoid Feature

Author

Takeshita, Masaki, primary, Kadoya, Naotaka, additional, Syouji, Masatoshi, additional, Amaya, Kouji, additional, Yoshikawa, Akemi, additional, Nojima, Naomi, additional, Fukushima, Wataru, additional, Izumi, Ryouhei, additional, and Saitoh, Katsuhiko, additional

Published
2011
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37. Massive pneumoretroperitoneum arising from emphysematous cholecystitis: a case report and the literature review.

Author

Yasumichi Yagi, Shozo Sasaki, Itsuro Terada, Akemi Yoshikawa, Wataru Fukushima, Hirohisa Kitagawa, Takashi Fujimura, Ryohei Izumi, Katsuhiko Saito, Yagi, Yasumichi, Sasaki, Shozo, Terada, Itsuro, Yoshikawa, Akemi, Fukushima, Wataru, Kitagawa, Hirohisa, Fujimura, Takashi, Izumi, Ryohei, and Saito, Katsuhiko

Subjects
CHOLECYSTECTOMY, CHOLECYSTITIS, IRRIGATION (Medicine), KLEBSIELLA, SEPSIS, SYMPTOMS, PNEUMOPERITONEUM, KLEBSIELLA infections, DISEASE complications
Abstract

Background: Emphysematous cholecystitis is a severe variant of acute cholecystitis caused by anaerobic bacteria. Although intraperitoneal air as a complication has been described in association with emphysematous cholecystitis, pneumoretroperitoneum arising from emphysematous cholecystitis is extremely rare. Herein, we describe a rare case of pneumoretroperitoneum arising from emphysematous cholecystitis that was successfully treated with emergency surgery.Case Presentation: An 84-year-old male was transported to the Emergency Department of our hospital for acute abdomen. Computed tomography revealed acute cholecystitis accompanied by emphysematous change. Computed tomography also revealed massive pneumoretroperitoneum complicated with pneumobilia and gas in the hepatoduodenal ligament. Clinical findings fulfilled the diagnostic criteria for systemic inflammatory response syndrome and sepsis. Emergency surgery was carried out with a diagnosis of both emphysematous cholecystitis and gastrointestinal perforation. Intraoperative findings revealed acute gangrenous cholecystitis and pneumoretroperitoneum presenting with an odor-free foamy abscess along the loose connective tissue behind the ascending colon and mesocolon. No evidence of gastrointestinal perforation was found during surgery. Therefore, cholecystectomy and lavage drainage were performed. Bacterial culture examination isolated a single species of anaerobe, Klebsiella pneumoniae, which was considered to be the cause of emphysematous cholecystitis, pneumobilia, and pneumoretroperitoneum.Conclusions: Emphysematous cholecystitis should be considered as a possible cause of pneumoretroperitoneum. The present case is the first report of massive pneumoretroperitoneum extending to the dorsal side of the ascending mesocolon as a complication of emphysematous cholecystitis. [ABSTRACT FROM AUTHOR]

Published
2015
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43. A case of fluminant breast cancer with meningeal carcinomatosis.

Author

TAJIMA, Hidehiro, primary, IZUMI, Ryohei, additional, TAKESHITA, Masaki, additional, NAGAI, Noboru, additional, MATSUMURA, Akihiro, additional, MURAOKA, Keiichi, additional, FUKUSHIMA, Wataru, additional, KADOYA, Naotaka, additional, HIROSAWA, Hisashi, additional, HINO, Yusuke, additional, and SAITO, Katsuhiko, additional

Published
2002
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50. Evaluation of the Effects of Hepatic Arterial Infusion and Transcatheter Arterial Embolization Therapy for Metastatic Colorectal Liver Cancers on the Differences in Vascularity of the Hepatic Metastases.

Author

Kadoya, Naotaka, primary, Izumi, Ryouhei, additional, Hirosawa, Hisashi, additional, Fukushima, Wataru, additional, Muraoka, Keiichi, additional, Itoh, Hiroshi, additional, Terada, Itsuro, additional, Yamazaki, Tohru, additional, and Amaya, Kouji, additional

Published
2000
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