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11. The Global academic research organization network: Data sharing to cure diseases and enable learning health systems.

Author

Fukushima, Masanori, Austin, Christopher, Sato, Norihiro, Maruyama, Tatsuya, Navarro, Eileen, Rocca, Mitra, Demotes, Jacques, Haendel, Melissa, Volchenboum, Samuel L, Cowperthwaite, Matthew, Silverstein, Jonathan C, Webb, Chris, Sim, Ida, Chase, Marianne, Speakman, John, Augustine, Erika, Ford, Daniel E, and Kush, Rebecca

Subjects
data sharing, global, harmonization, registry, standards
Abstract

Introduction:Global data sharing is essential. This is the premise of the Academic Research Organization (ARO) Council, which was initiated in Japan in 2013 and has since been expanding throughout Asia and into Europe and the United States. The volume of data is growing exponentially, providing not only challenges but also the clear opportunity to understand and treat diseases in ways not previously considered. Harnessing the knowledge within the data in a successful way can provide researchers and clinicians with new ideas for therapies while avoiding repeats of failed experiments. This knowledge transfer from research into clinical care is at the heart of a learning health system. Methods:The ARO Council wishes to form a worldwide complementary system for the benefit of all patients and investigators, catalyzing more efficient and innovative medical research processes. Thus, they have organized Global ARO Network Workshops to bring interested parties together, focusing on the aspects necessary to make such a global effort successful. One such workshop was held in Austin, Texas, in November 2017. Representatives from Japan, Taiwan, Singapore, Europe, and the United States reported on their efforts to encourage data sharing and to use research to inform care through learning health systems. Results:This experience report summarizes presentations and discussions at the Global ARO Network Workshop held in November 2017 in Austin, TX, with representatives from Japan, Korea, Singapore, Taiwan, Europe, and the United States. Themes and recommendations to progress their efforts are explored. Standardization and harmonization are at the heart of these discussions to enable data sharing. In addition, the transformation of clinical research processes through disruptive innovation, while ensuring integrity and ethics, will be key to achieving the ARO Council goal to overcome diseases such that people not only live longer but also are healthier and happier as they age. Conclusions:The achievement of global learning health systems will require further exploration, consensus-building, funding aligned with incentives for data sharing, standardization, harmonization, and actions that support global interests for the benefit of patients.

Published
2019

12. Nationwide registry for patients with neuroendocrine neoplasm of pancreas, gastrointestinal tract, lungs, bronchi, or thymus in Japan

Author

Masui, Toshihiko, Ito, Tetsuhide, Komoto, Izumi, Kojima, Shinsuke, Kasai, Yosuke, Tanabe, Minoru, Hara, Kazuo, Hirano, Satoshi, Okusaka, Takuji, Ichikawa, Yasushi, Kinugasa, Yusuke, Kokudo, Norihiro, Kudo, Atsushi, Sakurai, Akihiro, Sugihara, Kenichi, Date, Hiroshi, Haruma, Ken, Hijioka, Susumu, Hirata, Koichi, Yamano, Hiroo, Sakamine, Motohiro, Kikuchi, Takashi, Fukushima, Masanori, Imamura, Masayuki, and Uemoto, Shinji

Published
2022
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14. Total bile acids levels as a stratification tool for screening portopulmonary hypertension in patients with decompensated cirrhosis.

Author

Tajima, Kazuaki, Miuma, Satoshi, Miyaaki, Hisamitsu, Matsuo, Satoshi, Shimakura, Akane, Mori, Tomotaka, Takahashi, Kosuke, Nakao, Yasuhiko, Fukushima, Masanori, Haraguchi, Masafumi, Sasaki, Ryu, Ozawa, Eisuke, and Nakao, Kazuhiko

Subjects
TRICUSPID valve insufficiency, LOGISTIC regression analysis, MULTIPLE regression analysis, URSODEOXYCHOLIC acid, BILE acids
Abstract

Aim: Echocardiography is necessary for portopulmonary hypertension diagnosis, and identifying patients with cirrhosis who require it is challenging. In this study, we aimed to investigate the utility of the total bile acid (TBA) levels as a screening tool for identifying patients with decompensated cirrhosis who should undergo echocardiography for portopulmonary hypertension diagnosis. Methods: We evaluated 135 patients with decompensated cirrhosis who underwent liver transplantation. Subsequently, factors contributing to tricuspid regurgitation pressure gradient (TRPG) elevation (≥30 mmHg) were analyzed using preoperative data, including the TBA levels. Results: The median age of patients was 58 years (61 women), and 45 and 90 patients had Child–Turcotte–Pugh grades of B and C, respectively. The median TRPG level was 21 mmHg, and 17 patients (12.6%) showed TRPG elevation. Multiple logistic regression analysis revealed that elevated TBA (odds ratio 4.322; p = 0.013) and main pulmonary artery diameter ≥33 mm (odds ratio 4.333; p = 0.016) were significantly associated with TRPG elevation. The TBA cut‐off value (167.7 μmol/L) showed a high diagnostic performance, with 70.6% sensitivity and 64.4% specificity. Ursodeoxycholic acid (UDCA) administration increased the TBA levels dose‐dependently. Analysis stratified by UDCA use revealed that in patients not taking UDCA (n = 59), elevated TBA levels and younger age significantly contributed to TRPG elevation. However, in those taking UDCA (n = 76), this contribution disappeared, suggesting that UDCA consumption reduced TBA levels' efficiency in diagnosing TRPG elevation. Conclusions: The TBA levels may be a potential screening tool for TRPG elevation; however, caution is warranted when interpreting cases treated with UDCA. [ABSTRACT FROM AUTHOR]

Published
2024
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22. Are transmembrane 6 superfamily member 2 gene polymorphisms associated with steatohepatitis after pancreaticoduodenectomy?

Author

Mori, Tomotaka, Ozawa, Eisuke, Sasaki, Ryu, Shimakura, Akane, Takahashi, Kosuke, Kido, Yoko, Kanda, Yasuko, Matsuo, Satoshi, Tajima, Kazuaki, Beppu, Asami, Nakao, Yasuhiko, Fukushima, Masanori, Haraguchi, Masafumi, Miuma, Satoshi, Miyaaki, Hisamitsu, Adachi, Tomohiko, Eguchi, Susumu, Okano, Shinji, and Nakao, Kazuhiko

Subjects
FATTY liver, NON-alcoholic fatty liver disease, GENETIC polymorphisms, PANCREATICODUODENECTOMY, HEPATIC fibrosis
Abstract

Aim: After pancreaticoduodenectomy, 20–40% of patients develop steatotic liver disease (SLD), and steatohepatitis can be a problem. Although patatin‐like phospholipase domain‐containing 3 protein (PNPLA3) and transmembrane 6 superfamily member 2 (TM6SF2) polymorphisms are involved in SLD and steatohepatitis development, whether this is the case after pancreaticoduodenectomy is unclear. Methods and Results: Forty‐three patients with pancreatic cancer who underwent pancreaticoduodenectomy at our hospital between April 1, 2018, and March 31, 2021, were included. We extracted DNA from noncancerous areas of residual specimens after pancreaticoduodenectomy and determined PNPLA3 and TM6SF2 gene polymorphisms using real‐time polymerase chain reaction. SLD was defined as a liver with an attenuation value of ≤40 HU or a liver‐to‐spleen ratio of ≤0.9 on computed tomography. We defined high hepatic fibrosis indexes (HFI) instead of steatohepatitis as a Fibrosis‐4 index of ≥2.67 or nonalcoholic fatty liver disease fibrosis score of ≥0.675 in patients with SLD. The cumulative incidence of SLD (P = 0.299) and high HFI (P = 0.987) after pancreaticoduodenectomy were not significantly different between the PNPLA3 homozygous and minor allele groups. The incidences of high HFI at 1 year after pancreaticoduodenectomy were 16.8% and 27.0% in the TM6SF2 major homozygous and minor allele groups, respectively, with a significant difference in the cumulative incidence (P = 0.046). Conclusion: The TM6SF2 minor allele may contribute to steatohepatitis development after pancreaticoduodenectomy. [ABSTRACT FROM AUTHOR]

Published
2024
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25. Comparative study of the effect of neuromuscular electrical stimulation and oral administration of branched-chain amino acid on preventing sarcopenia in patients after living-donor liver transplantation: study protocol for an open-label randomized controlled trial

Author

Haraguchi, Masafumi, Ichinose, Kunihiro, Miyaaki, Hisamitsu, Hanada, Masatoshi, Fukushima, Masanori, Sasaki, Ryu, Miuma, Satoshi, Hara, Takanobu, Kugiyama, Tota, Soyama, Akihiko, Hidaka, Masaaki, Tsuji, Ayumi, Yano, Rintaro, Sekino, Motohiro, Takahata, Hideaki, Eguchi, Susumu, and Nakao, Kazuhiko

Published
2021
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27. Patient-reported health-related quality of life up to three years after the treatment with permanent brachytherapy: Outcome of the large-scale, prospective longitudinal study in Japanese–Prostate Cancer Outcome Study by Permanent I-125 Seed Implantation (J-POPS)

Author

Koga, Hirofumi, Naito, Seiji, Ishiyama, Hiromichi, Yorozu, Atsunori, Saito, Shiro, Kojima, Shinsuke, Higashide, Satoshi, Kikuchi, Takashi, Nakamura, Katsumasa, Dokiya, Takushi, and Fukushima, Masanori

Published
2019
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34. Nationwide Japanese Prostate Cancer Outcome Study of Permanent Iodine-125 Seed Implantation (J-POPS): first analysis on survival

Author

Ito, Kazuto, Saito, Shiro, Yorozu, Atsunori, Kojima, Shinsuke, Kikuchi, Takashi, Higashide, Satoshi, Aoki, Manabu, Koga, Hirofumi, Satoh, Takefumi, Ohashi, Toshio, Nakamura, Katsumasa, Katayama, Norihisa, Tanaka, Nobumichi, Nakano, Masahiro, Shigematsu, Naoyuki, Dokiya, Takushi, Fukushima, Masanori, and For the J-POPS Investigators

Published
2018
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48. Comparison of the novel Franseen needle versus the fine‐needle aspiration needle in endoscopic ultrasound‐guided tissue acquisition for cancer gene panel testing: A propensity score‐matching analysis.

Author

Mori, Tomotaka, Ozawa, Eisuke, Shimakura, Akane, Takahashi, Kosuke, Matsuo, Satoshi, Tajima, Kazuaki, Nakao, Yasuhiko, Fukushima, Masanori, Sasaki, Ryu, Miuma, Satoshi, Miyaaki, Hisamitsu, Okano, Shinji, and Nakao, Kazuhiko

Subjects
CANCER genes, NEEDLE biopsy, TISSUES, MULTIVARIATE analysis, ODDS ratio
Abstract

Background and Aim: Reports have indicated that a surface area of 4 mm2 or more of collected tissue sections could provide the recommended total DNA for the OncoGuide NCC Oncopanel system, which is a cancer gene panel test developed in Japan. We wished to compare the percentage of tissue sections collected by endoscopic ultrasound‐assisted tissue acquisition (EUS‐TA) with surface areas of ≥4 mm2 between a conventional needle, namely the EZ Shot 3 Plus (Olympus Medical Japan, Tokyo, Japan) (EZ3), and the recent SonoTip TopGain (MediGlobe, Rohrdorf, Germany) (TopGain). Method: From April 2010 to December 2021, among 693 EUS‐TA cases, EZ3 was used in 390 cases and TopGain in 45. The EZ3 and TopGain groups were matched in a 1:1 ratio with a tolerance of 0.2, with 35 patients each matched using propensity score analysis. Results: The TopGain group had a significantly higher percentage of cases with a tissue area of ≥4 mm2 than the EZ3 group (42.9% vs 68.6%, P = 0.030). Multivariate analysis revealed an association between TopGain and tissue areas of ≥4 mm2 (odds ratio 2.996, 95% confidence interval 1.068–8.403, P = 0.037). Conclusions: EUS‐TA using TopGain significantly collected more ≥4 mm2 tissue area compared with EZ3, suggesting its usefulness for cancer gene panel testing. [ABSTRACT FROM AUTHOR]

Published
2023
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