284 results on '"Fukumori, Akio"'
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2. Intramembrane Proteolysis of GXGD-type Aspartyl Proteases Is Slowed by a Familial Alzheimer Disease-like Mutation*
3. Ribavirin Treatment for Severe Schizophrenia with Anti-Borna Disease Virus 1 Antibodies 30 Years after Onset
4. APLP2 is predominantly cleaved by β‐secretase and γ‐secretase in the human brain
5. Data Science for QSAR for Protease activity
6. An Alzheimer‐associated TREM2 variant occurs at the ADAM cleavage site and affects shedding and phagocytic function
7. Substrate recruitment of γ‐secretase and mechanism of clinical presenilin mutations revealed by photoaffinity mapping
8. Generation and deposition of Aβ43 by the virtually inactive presenilin‐1 L435F mutant contradicts the presenilin loss‐of‐function hypothesis of Alzheimer's disease
9. Active site geometry stabilization of a presenilin homolog by the lipid bilayer promotes intramembrane proteolysis
10. Author response: Active site geometry stabilization of a presenilin homolog by the lipid bilayer promotes intramembrane proteolysis
11. Active site geometry stabilization of a presenilin homolog by the lipid bilayer promotes intramembrane proteolysis
12. ELISA Evaluation of Tau Accumulation in the Brains of Patients with Alzheimer Disease
13. Additional file 1 of Deletion of B-cell translocation gene 2 (BTG2) alters the responses of glial cells in white matter to chronic cerebral hypoperfusion
14. Isotype analysis of human anti-Borna disease virus antibodies in Japanese psychiatric and general population
15. Upregulated expression of a subset of genes in APP ; ob / ob mice: Evidence of an interaction between diabetes‐linked obesity and Alzheimer’s disease
16. Presenilin-dependent gamma- secretase on plasma membrane and endosomes is functionally distinct
17. Characterization of Tau ELISAs for Evaluating Tau Accumulation in the Brains With Alzheimer’s Disease
18. Important functional role of residue x of the presenilin GxGD protease active site motif for APP substrate cleavage specificity and substrate selectivity of γ-secretase
19. Development of new screening system for Alzheimer disease, in vitro Aβ sink assay, to identify the dissociation of soluble Aβ from fibrils
20. Substrate recruitment by γ-secretase
21. Pathogenic Aβ generation in familial Alzheimer’s disease: novel mechanistic insights and therapeutic implications
22. Interaction between APOE genotype and diabetes in cognitive decline
23. Increased levels of Aβ42 decrease the lifespan of ob/ob mice with dysregulation of microglia and astrocytes
24. Requirement for small side chain residues within the GxGD-motif of presenilin for γ-secretase substrate cleavage
25. Inhibition of endocytosis activates alternative degradation pathway of βAPP in cultured cells
26. Aβ induces endoplasmic reticulum stress causing possible proteasome impairment via the endoplasmic reticulum–associated degradation pathway
27. Aβ43‐producing PS1 FAD mutants cause altered substrate interactions and respond to γ‐secretase modulation
28. P3-068: INCREASED LEVELS OF Aβ42 DECREASE THE LIFE SPAN OF OB/OB MICE WITH DYSREGULATION OF MICROGLIA AND ASTROCYTES
29. Atherogenic LOX-1 signaling is controlled by SPPL2-mediated intramembrane proteolysis
30. Upregulated expression of a subset of genes in APP;ob/ob mice: Evidence of an interaction between diabetes‐linked obesity and Alzheimer's disease.
31. Increased levels of Aβ42 decrease the lifespan of ob/ob mice with dysregulation of microglia and astrocytes.
32. Making the final cut: pathogenic amyloid-β peptide generation by γ-secretase
33. Two Neuropsychiatric Cases Seropositive for Bornavirus Improved by Ribavirin
34. Identifizierung von Substratbindestellen in der γ-Sekretase
35. Purification, pharmacological modulation, and biochemical characterization of interactors of endogenous human [gamma]-secretase
36. Semagacestat Is a Pseudo-Inhibitor of γ-Secretase
37. Substrate determinants of signal peptide peptidase-like 2a (SPPL2a)-mediated intramembrane proteolysis of the invariant chain CD74
38. Proteolytic Processing of Neuregulin 1 Type III by Three Intramembrane-cleaving Proteases
39. Cleavage and cell adhesion properties of human epithelial cell adhesion molecule (HEPCAM).
40. Cleavage and Cell Adhesion Properties of Human Epithelial Cell Adhesion Molecule (HEPCAM)
41. Rare variants in β-Amyloid precursor protein (APP) and Parkinson’s disease
42. The Yeast ER-Intramembrane Protease Ypf1 Refines Nutrient Sensing by Regulating Transporter Abundance
43. Shedding of glycan‐modifying enzymes by signal peptide peptidase‐like 3 (SPPL3) regulates cellular N‐glycosylation
44. Regulated Intramembrane Proteolysis and Degradation of Murine Epithelial Cell Adhesion Molecule mEpCAM
45. Foamy Virus Envelope Protein Is a Substrate for Signal Peptide Peptidase-like 3 (SPPL3)
46. Correction: Differential Regulation of Amyloid Precursor Protein/Presenilin 1 Interaction during Ab40/42 Production Detected Using Fusion Constructs
47. Differential Regulation of Amyloid Precursor Protein/Presenilin 1 Interaction during Ab40/42 Production Detected Using Fusion Constructs
48. Generation of Alzheimer Disease-associated Amyloid β42/43 Peptide by γ-Secretase Can Be Inhibited Directly by Modulation of Membrane Thickness
49. Novel γ-Secretase Enzyme Modulators Directly Target Presenilin Protein
50. O1-05-07: Gamma-secretase modulator resistance can be overcome for many pathogenic presenilin mutants by second-generation compounds
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