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The use of genome-wide association results combined with other genomic approaches may uncover genes and metabolic pathways related to complex traits. In this study, the phenotypic and genotypic data of 1475 Nellore (Bos indicus) cattle and 941,033 single nucleotide polymorphisms (SNPs) were used for genome-wide association study (GWAS) and copy number variations (CNVs) analysis in order to identify candidate genes and putative pathways involved with the feed conversion ratio (FCR). The GWAS was based on the Bayes B approach analyzing genomic windows with multiple regression models to estimate the proportion of genetic variance explained by each window. The CNVs were detected with PennCNV software using the log R ratio and B allele frequency data. CNV regions (CNVRs) were identified with CNVRuler and a linear regression was used to associate CNVRs and the FCR. Functional annotation of associated genomic regions was performed with the Database for Annotation, Visualization and Integrated Discovery (DAVID) and the metabolic pathways were obtained from the Kyoto Encyclopedia of Genes and Genomes (KEGG). We showed five genomic windows distributed over chromosomes 4, 6, 7, 8, and 24 that explain 12 % of the total genetic variance for FCR, and detected 12 CNVRs (chromosomes 1, 5, 7, 10, and 12) significantly associated [false discovery rate (FDR) < 0.05] with the FCR. Significant genomic regions (GWAS and CNV) harbor candidate genes involved in pathways related to energetic, lipid, and protein metabolism. The metabolic pathways found in this study are related to processes directly connected to feed efficiency in beef cattle. It was observed that, even though different genomic regions and genes were found between the two approaches (GWAS and CNV), the metabolic processes covered were related to each other. Therefore, a combination of the approaches complement each other and lead to a better understanding of the FCR.

Submitted by Vitor Silverio Rodrigues (vitorsrodrigues@reitoria.unesp.br) on 2014-05-27T11:25:56Z No. of bitstreams: 0 Made available in DSpace on 2014-05-27T11:25:56Z (GMT). No. of bitstreams: 0 Previous issue date: 2011-07-01 The purpose of this paper is to establish criteria that could guide the diagnosis, prognosis and treatment of canine mammary neoplasias. It was elaborated during the Mammary Pathology Meeting: Diagnosis, Prognosis and Treatment of the Canine Mammary Neoplasm, held on November 6 th and 7 th, 2010 in Belo Horizonte - MG, Brazil, sponsored by the Laboratory of Comparative Pathology - UFMG, with the support of the Brazilian Association of Veterinary Pathology (ABPV) and Brazilian Association of Veterinary Oncology (ABROVET). Academics from several regions of Brazil were present and contributed to this work. Laboratório de Patologia Comparada Departamento de Patologia Geral ICB/UFMG, Belo Horizonte - MG Hospital Veterinário Escola de Veterinária UFMG, Belo Horizonte - MG Escola de Medicina Veterinária e Zootecnia UFT Araguaína -TO e Hospital Veterinário, UNIFRAN, Franca - SP Departamento de Medicina Veterinária UFLA, Lavras - MG Faculdade de Ciências da Saúde UNIVALE, Governador Valadares - MG Departamento de Patologia e Clínicas Escola de Medicina Veterinária UFBA, Salvador - BA Departamento de Patologia Veterinária Faculdade de Ciências Agrárias e Veterinárias UNESP, Jaboticabal - SP Departamento de Clínica e Cirurgia Veterinária Faculdade de Ciências Agrárias e Veterinárias UNESP, Jaboticabal - SP Departamento de Clínica Veterinária Faculdade de Medicina Veterinária e Zootecnia UNESP, Botucatu - SP Departamento de Patologia Animal Faculdade de Veterinária UFPEL, Pelotas - RS Serviço de Oncologia Clínico-Cirúrgica PROVET - Medicina Veterinária Diagnóstica e de Especialidades, São Paulo - SP Setor de Anatomia Patológica Veterinária Departamento de Patologia e Clínica Veterinária Faculdade de Veterinária, UFF, Niteroi - RJ Hospital de Clínicas Veterinárias UFRGS, Porto Alegre - RS Departamento de Clínica e Cirurgia Veterinária Escola de Veterinária UFMG, Belo Horizonte - MG Centro de Estudos no Prognóstico do Câncer Departamento de Biologia Molecular FAMERP, São José do Rio Preto -SP Curso de Medicina Veterinária Centro de Ciências Biológicas e da Saúde Universidade Norte do Paraná, Londrina-PR Oncologia Veterinária, Belo Horizonte - MG Departamento de Clínica e Cirurgia Veterinária UFPI, Teresina - PI Hospital Universitário de Clínicas Veterinária Faculdade de Veterinária UFPEL, Pelotas - RS Laboratório de Saúde Animal IMA - Instituto Mineiro de Agropecuária, Belo Horizonte - MG Departamento de Clínica Veterinária Faculdade de Veterinária UFPEL, Pelotas - RS Laboratório de Patologia IFNMG, Salinas - MG Hospital Universitário Veterinário UNIPAMPA, Uruguaiana - RS Laboratório de Oncologia Experimental Departamento de Radiologia e Oncologia Faculdade de Medicina, USP, São Paulo - SP Departamento de Medicina Veterinária UFRPE, Recife - PE Departamento de Patologia Faculdade de Medicina Veterinária e Zootecnia USP, São Paulo - SP Departamento de Ciências Básicas Faculdade de Zootecnia e Engenharia de Alimentos USP, Pirassununga - SP Patologia Veterinária UNIVIÇOSA/FACISA, Viçosa - MG Departamento de Medicina Veterinária Preventiva UEL, Londrina - PR Departamento de Ciências Básicas Faculdade de Odontologia UFF, Nova Friburgo, RJ Departamento de Patologia Veterinária Faculdade de Ciências Agrárias e Veterinárias UNESP, Jaboticabal - SP Departamento de Clínica e Cirurgia Veterinária Faculdade de Ciências Agrárias e Veterinárias UNESP, Jaboticabal - SP Departamento de Clínica Veterinária Faculdade de Medicina Veterinária e Zootecnia UNESP, Botucatu - SP