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15. Japanese Society of Internal Medicine

Author

Kawano, Hiroaki, Kohno, Yusuke, Izumida, Seiya, Tsuneto, Akira, Fukae, Satoki, Takeno, Masayoshi, Koide, Yuji, and Maemura, Koji

Subjects
cardiovascular system, Anticoagulant, cardiovascular diseases, Warfarin, Atrial fibrillation, Thrombus, Cancer
Abstract

A 72-year-old man with non-valvular atrial fibrillation and metastatic liver and lung cancer after surgery for colon cancer developed thrombosis in the right atrium one month after decreasing the dose of warfarin due to the introduction of double anti-platelet therapy for coronary stent implantation. Restoring the warfarin dose with ordinary control for two months did not result in any changes in the size of the thrombus; however, the subsequent substitution of rivaroxaban (oral treatment with a direct Factor Xa inhibitor) for warfarin ultimately resolved the thrombosis.

Published
2015

19. Japanese Society of Internal Medicine

Author

Kusumoto, Saburo, Kawano, Hiroaki, Takeno, Masayoshi, Yonekura, Tsuyoshi, Koide, Yuji, Abe, Kuniko, Doi, Yoshinori, Fukae, Satoki, Komiya, Norihiro, and Maemura, Koji

Subjects
Acute myocarditis, cardiovascular system, Complete atrioventricular block, Cardiogenic shock, Hypertrophic cardiomyopathy, Mri
Abstract

A 67-year-old woman was referred to our hospital with a sudden syncopal attack. She suffered from cardiogenic shock due to left ventricular (LV) outflow stenosis with simultaneous complete atrioventricular (AV) block. An endomyocardial biopsy of the left ventricle demonstrated myocardial disarray and myocardial fibrous and edematous tissue with infiltration of mononuclear cells. Cardiac magnetic resonance imaging (cMRI) detected a damaged septal area that was likely associated with the conduction disturbance. The diagnosis was hypertrophic cardiomyopathy accompanied by acute myocarditis. Although the LV outflow stenosis was transient, the complete AV block was persistent, thus requiring permanent pacemaker implantation.

Published
2012

21. Prognostic Significance of Premature Ventricular Contractions without Obvious Heart Diseases Determined by Standard 12‐Lead Electrocardiography Considering their Morphology

Author

Haruta, Daisuke, Akahoshi, Masazumi, Hida, Ayumi, Sera, Nobuko, Imaizumi, Misa, Ichimaru, Shinichiro, Nakashima, Eiji, Takahashi, Ikuno, Ohishi, Waka, Fukae, Satoki, and Maemura, Koji

Subjects
Male, Electrocardiography, Nuclear Weapons, Japan, Risk Factors, Humans, Female, Original Articles, Survivors, Middle Aged, Prognosis, Ventricular Premature Complexes, Aged
Abstract

BACKGROUND: Although ventricular premature contraction (VPC) commonly arises in subjects with and without heart diseases, the prognosis of VPC has remained controversial and the effect of their morphology on mortality has not been fully determined in subjects without obvious heart diseases. The objective of this study was to assess the morphologic effect of VPC on mortality. METHODS: Japanese atomic bomb survivors (n = 6685) underwent baseline health examinations and standard 12‐lead electrocardiogram (ECG) between January 1990 and December 1991. Of these, we extracted data from 5,685 (67.1% women) subjects who had neither heart diseases nor electrocardiographic abnormalities at baseline. Among them, we identified 131 VPC cases using standard 12‐lead ECG and classified them into left bundle branch block (LBBB) type (n = 74), right bundle branch block (RBBB) type (n = 21), and undetermined type (n = 36) according to their morphology. These subjects were followed up until December 2008; we compared all‐cause, cardiac and coronary heart disease (CHD) mortality rates using multivariate Cox regression analysis between those with and without VPC. RESULTS: No VPCs were associated with all‐cause and cardiac mortality, but the LBBB type was significantly associated with CHD mortality (hazard ratio, 2.73; 95% confidence interval, 1.11–6.73) after controlling for age, sex, smoking status, alcohol consumption, and underlying diseases. CONCLUSIONS: Among Japanese atomic bomb survivors without obvious heart diseases, LBBB‐type VPC was associated with increased CHD mortality. Larger studies are needed to confirm the effect of morphology as it might help to predict the risk.

Published
2015

22. The Japanese Society of Internal Medicine

Author

Tomihara, Aki, Ashizawa, Naoto, Abe, Kuniko, Kinoshita, Naoe, Chihaya, Keisuke, Yonekura, Tsuyoshi, Fukae, Satoki, Ashizawa, Kazuto, Eishi, Kiyoyuki, Hayashi, Tomayoshi, and Yano, Katsusuke

Subjects
abdominal aortic aneurysm, descending thoracic aortic dissection, cardiovascular system, Marfans syndrome, postpartum
Abstract

A 24-year-old pregnant woman with Marfans syndrome delivered by cesarean section during the 38th week of gestation. Although aortic root dilatation did not increase during pregnancy, three months after delivery, the patient noticed a pulsatile abdominal mass. Aortic aneurysm was diagnosed and surgical replacement of the infrarenal abdominal aorta to the common iliac arteries and reconstruction of the inferior mesenteric artery were performed. Moreover, the patient subsequently developed a Stanford type B thoracic aortic dissection, even after more than four months of β-blockade.

Published
2006

23. The Japanese Society of Internal Medicine

Author

Kawano, Hiroaki, Tomichi, Yoichi, Fukae, Satoki, Koide, Yuji, Toda, Genji, and Yano, Katsusuke

Subjects
myocardial infarction, cardiovascular system, cardiovascular diseases, aortic dissection, cerebral infarction, reperfusion injury, sudden cardiac death
Abstract

It is sometimes very difficult to diagnose dissecting aortic aneurysms in the early stage. We report an autopsy case in which an acute myocardial infarction and cerebral infarction simultaneously occurred and the symptoms were transiently ameliorated in a patient with an acute aortic dissection.

Published
2006

24. Efficacy of bepridil to prevent ventricular fibrillation in severe form of early repolarization syndrome

Author

Katsuumi, Goro, Shimizu, Wataru, Watanabe, Hiroshi, Noda, Takashi, Nogami, Akihiko, Ohkubo, Kimie, Makiyama, Takeru, Takehara, Naofumi, Kawamura, Yuichiro, Hosaka, Yukio, Sato, Masahito, Fukae, Satoki, Chinushi, Masaomi, Oda, Hirotaka, Okabe, Masaaki, Kimura, Akinori, Maemura, Koji, Watanabe, Ichiro, Kamakura, Shiro, Horie, Minoru, Aizawa, Yoshifusa, Makita, Naomasa, and Minamino, Tohru

Published
2014
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25. An Angiotensin Receptor Blocker and Spironolactone Enabled A Withdrawal from Furosemide and KCl in A Patient with Pseudo-Bartter's Syndrome

Author

Ashizawa, Naoto, Fukae, Satoki, Tanaka, Kyoei, Suzuki, Nobuaki, Seto, Shinji, and Yano, Katsusuke

Subjects
Pseudo-Bartter'ssyndrome, Angiotensinreceptorblocker, Furosemide, Totalbodypotassium, Aldosteronebreakthrough
Abstract

A 30-year-old woman with pseudo-Bartter's syndrome was referred to our department because of hypokalemic symptoms caused by outrageous abuse of furosemide and by KCl infusion administered to compensate for it. As an attempt to break this vicious cycle, we first tried to change furosemide with azosemide, a long-lasting loop diuretics, to avoid acute excessive diuresis and excretion of potassium. Administration of losartan effectively attenuated the concentration of extremely activated plasma aldosterone. Administration of spironolactone reduced aldosterone breakthrough induced by losartan and the patient was released from both furosemide and KCl. Blocking renin-angiotensin-aldosterone system demonstrated to be an effective treatment for pseudo-Bartter's syndrome by the improvement of the total body potassium level which was decreased before treatment., Acta medica Nagasakiensia. 2004, 49(3), p.107-109

Published
2004

26. Clinical characteristics and risk of arrhythmia recurrences in patients with idiopathic ventricular fibrillation associated with early repolarization

Author

Watanabe, Hiroshi, Nogami, Akihiko, Ohkubo, Kimie, Kawata, Hiro, Hayashi, Yuka, Ishikawa, Taisuke, Makiyama, Takeru, Nagao, Satomi, Yagihara, Nobue, Takehara, Naofumi, Kawamura, Yuichiro, Sato, Akinori, Okamura, Kazuki, Hosaka, Yukio, Sato, Masahito, Fukae, Satoki, Chinushi, Masaomi, Oda, Hirotaka, Okabe, Masaaki, Kimura, Akinori, Maemura, Koji, Watanabe, Ichiro, Kamakura, Shiro, Horie, Minoru, Aizawa, Yoshifusa, Shimizu, Wataru, and Makita, Naomasa

Published
2012
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27. Prognostic Significance of Premature Ventricular Contractions without Obvious Heart Diseases Determined by Standard 12-Lead Electrocardiography Considering their Morphology

Author

Haruta, Daisuke, primary, Akahoshi, Masazumi, additional, Hida, Ayumi, additional, Sera, Nobuko, additional, Imaizumi, Misa, additional, Ichimaru, Shinichiro, additional, Nakashima, Eiji, additional, Takahashi, Ikuno, additional, Ohishi, Waka, additional, Fukae, Satoki, additional, and Maemura, Koji, additional

Published
2015
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29. Relationships Between Clinical Characteristics and Decreased Plakoglobin and Connexin 43 Expressions in Myocardial Biopsies From Patients With Arrhythmogenic Right Ventricular Cardiomyopathy

Author

Yoshida, Takeo, primary, Kawano, Hiroaki, additional, Kusumoto, Saburo, additional, Fukae, Satoki, additional, Koga, Seiji, additional, Ikeda, Satoshi, additional, Koide, Yuji, additional, Abe, Kuniko, additional, Hayashi, Tomayoshi, additional, and Maemura, Koji, additional

Published
2015
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31. Sodium Channelopathy Underlying Familial Sick Sinus Syndrome With Early Onset and Predominantly Male Characteristics

Author

Abe, Keisuke, Machida, Taku, Sumitomo, Naokata, Yamamoto, Hirokazu, Ohkubo, Kimie, Watanabe, Ichiro, Makiyama, Takeru, Fukae, Satoki, Kohno, Masaki, Harrell, Daniel T., Ishikawa, Taisuke, Tsuji, Yukiomi, Nogami, Akihiko, Watabe, Taichi, Oginosawa, Yasushi, Abe, Haruhiko, Maemura, Koji, Motomura, Hideki, Makita, Naomasa, Abe, Keisuke, Machida, Taku, Sumitomo, Naokata, Yamamoto, Hirokazu, Ohkubo, Kimie, Watanabe, Ichiro, Makiyama, Takeru, Fukae, Satoki, Kohno, Masaki, Harrell, Daniel T., Ishikawa, Taisuke, Tsuji, Yukiomi, Nogami, Akihiko, Watabe, Taichi, Oginosawa, Yasushi, Abe, Haruhiko, Maemura, Koji, Motomura, Hideki, and Makita, Naomasa

Abstract

Background-Sick sinus syndrome (SSS) is a common arrhythmia often associated with aging or organic heart diseases but may also occur in a familial form with a variable mode of inheritance. Despite the identifcation of causative genes, including cardiac Na channel (SCN5A), the pathogenesis and molecular epidemiology of familial SSS remain undetermined primarily because of its rarity. Methods and Results-We genetically screened 48 members of 15 SSS families for mutations in several candidate genes and determined the functional properties of mutant Na channels using whole-cell patch clamping. We identifed 6 SCN5A mutations including a compound heterozygous mutation. Heterologously expressed mutant Na channels showed loss-of-function properties of reduced or no Na current density in conjunction with gating modulations. Among 19 family members with SCN5A mutations, QT prolongation and Brugada syndrome were associated in 4 and 2 individuals, respectively. Age of onset in probands carrying SCN5A mutations was signifcantly less (mean±SE, 12.4±4.6 years; n=5) than in SCN5A-negative probands (47.0±4.6 years; n=10; P<0.001) or nonfamilial SSS (74.3±0.4 years; n=538; P<0.001). Meta-analysis of SSS probands carrying SCN5A mutations (n=29) indicated profound male predominance (79.3%) resembling Brugada syndrome but with a considerably earlier age of onset (20.9±3.4 years). Conclusions-The notable pathophysiological overlap between familial SSS and Na channelopathy indicates that familial SSS with SCN5A mutations may represent a subset of cardiac Na channelopathy with strong male predominance and early clinical manifestations., Circulation: Arrhythmia and Electrophysiology, 7(3), pp.511-517; 2014

Published
2014

32. Sodium Channelopathy Underlying Familial Sick Sinus Syndrome With Early Onset and Predominantly Male Characteristics

Author

Abe, Keisuke, primary, Machida, Taku, additional, Sumitomo, Naokata, additional, Yamamoto, Hirokazu, additional, Ohkubo, Kimie, additional, Watanabe, Ichiro, additional, Makiyama, Takeru, additional, Fukae, Satoki, additional, Kohno, Masaki, additional, Harrell, Daniel T., additional, Ishikawa, Taisuke, additional, Tsuji, Yukiomi, additional, Nogami, Akihiko, additional, Watabe, Taichi, additional, Oginosawa, Yasushi, additional, Abe, Haruhiko, additional, Maemura, Koji, additional, Motomura, Hideki, additional, and Makita, Naomasa, additional

Published
2014
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34. Response to Letter Regarding Article, “Electrocardiographic Characteristics and SCN5A Mutations in Idiopathic Ventricular Fibrillation Associated With Early Repolarization”

Author

Watanabe, Hiroshi, primary, Nogami, Akihiko, additional, Ohkubo, Kimie, additional, Kawata, Hiro, additional, Hayashi, Yuka, additional, Ishikawa, Taisuke, additional, Makiyama, Takeru, additional, Nagao, Satomi, additional, Yagihara, Nobue, additional, Takehara, Naofumi, additional, Kawamura, Yuichiro, additional, Sato, Akinori, additional, Okamura, Kazuki, additional, Hosaka, Yukio, additional, Sato, Masahito, additional, Fukae, Satoki, additional, Chinushi, Masaomi, additional, Oda, Hirotaka, additional, Okabe, Masaaki, additional, Kimura, Akinori, additional, Maemura, Koji, additional, Watanabe, Ichiro, additional, Kamakura, Shiro, additional, Horie, Minoru, additional, Aizawa, Yoshifusa, additional, Shimizu, Wataru, additional, and Makita, Naomasa, additional

Published
2012
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35. Cardiogenic Shock due to Left Ventricular Outflow Obstruction and Complete Atrioventricular Block in a Patient with Hypertrophic Cardiomyopathy with Acute Myocarditis

Author

Kusumoto, Saburo, primary, Kawano, Hiroaki, additional, Takeno, Masayoshi, additional, Yonekura, Tsuyoshi, additional, Koide, Yuji, additional, Abe, Kuniko, additional, Doi, Yoshinori, additional, Fukae, Satoki, additional, Komiya, Norihiro, additional, and Maemura, Koji, additional

Published
2012
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36. Electrocardiographic Characteristics and SCN5A Mutations in Idiopathic Ventricular Fibrillation Associated With Early Repolarization

Author

Watanabe, Hiroshi, primary, Nogami, Akihiko, additional, Ohkubo, Kimie, additional, Kawata, Hiro, additional, Hayashi, Yuka, additional, Ishikawa, Taisuke, additional, Makiyama, Takeru, additional, Nagao, Satomi, additional, Yagihara, Nobue, additional, Takehara, Naofumi, additional, Kawamura, Yuichiro, additional, Sato, Akinori, additional, Okamura, Kazuki, additional, Hosaka, Yukio, additional, Sato, Masahito, additional, Fukae, Satoki, additional, Chinushi, Masaomi, additional, Oda, Hirotaka, additional, Okabe, Masaaki, additional, Kimura, Akinori, additional, Maemura, Koji, additional, Watanabe, Ichiro, additional, Kamakura, Shiro, additional, Horie, Minoru, additional, Aizawa, Yoshifusa, additional, Shimizu, Wataru, additional, and Makita, Naomasa, additional

Published
2011
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37. Abstract 9290: Clinical, Electrocardiographic, and Genetic Characteristics of Patients with Idiopathic Ventricular Fibrillation Associated with Early Repolarization

Author

Watanabe, Hiroshi, primary, Nogami, Akihiko, additional, Ohkubo, Kimie, additional, Makiyama, Takeru, additional, Hayashi, Yuka, additional, Shimada, Toshio, additional, Nagao, Satomi, additional, Yagihara, Nobue, additional, Takehara, Naofumi, additional, Kawamura, Yuichiro, additional, Sato, Akinori, additional, Okamura, Kazuki, additional, Chinushi, Masaomi, additional, Hosaka, Yukio, additional, Sato, Masahito, additional, Fukae, Satoki, additional, Oda, Hirotaka, additional, Okabe, Masaaki, additional, Maemura, Koji, additional, Horie, Minoru, additional, Watanabe, Ichiro, additional, Aizawa, Yoshifusa, additional, and Makita, Naomasa, additional

Published
2011
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45. Double ventricular response via dual atrioventricular nodal pathways resulting with nonreentrant supraventricular tachycardia and successfully treated with radiofrequency catheter ablation

Author

Nakao, Kojiro, primary, Hayano, Motonobu, additional, Iliev, Ivan I., additional, Doi, Yoshiyuki, additional, Fukae, Satoki, additional, Matsuo, Kiyotaka, additional, Komiya, Norihiro, additional, Isomoto, Shojiro, additional, and Yano, Katsusuke, additional

Published
2001
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48. Electrocardiographic Characteristics and SCN5AMutations in Idiopathic Ventricular Fibrillation Associated With Early Repolarization

Author

Watanabe, Hiroshi, Nogami, Akihiko, Ohkubo, Kimie, Kawata, Hiro, Hayashi, Yuka, Ishikawa, Taisuke, Makiyama, Takeru, Nagao, Satomi, Yagihara, Nobue, Takehara, Naofumi, Kawamura, Yuichiro, Sato, Akinori, Okamura, Kazuki, Hosaka, Yukio, Sato, Masahito, Fukae, Satoki, Chinushi, Masaomi, Oda, Hirotaka, Okabe, Masaaki, Kimura, Akinori, Maemura, Koji, Watanabe, Ichiro, Kamakura, Shiro, Horie, Minoru, Aizawa, Yoshifusa, Shimizu, Wataru, and Makita, Naomasa

Abstract

Recently, we and others reported that early repolarization (J wave) is associated with idiopathic ventricular fibrillation. However, its clinical and genetic characteristics are unclear.

Published
2011
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49. Atrial Lesion and Diastolic Dysfunction May Be Associated With Atrial Fibrillation in Patients With Cardiac Amyloidosis.

Author

Otsuka K, Kawano H, Koike H, Sueyoshi E, Arakawa S, Fukae S, Takei A, Yoshimuta T, Ikeda S, and Maemura K

Abstract

Background: Atrial fibrillation (AF) is a common arrhythmia associated with cardiac amyloidosis (CA). Diastolic dysfunction and atrial lesions have been reported in patients with AF fibrillation. We aimed to evaluate the diastolic function and atrial lesions in patients with CA and AF., Methods and Results: We included 27 patients (mean age 72 years) with biopsy-confirmed CA. We analyzed the average E/e' as diastolic function using echocardiography and atrial late gadolinium enhancement (LGE) as an atrial lesion using cardiac magnetic resonance imaging (CMRI). We compared these parameters among 20 patients with sinus rhythm (SR) and 7 with AF. Echocardiography examination showed that average E/e' were larger in the AF group than in the SR group (average E/e': AF, 21.3 [14.5-30.3]; SR, 14.2 [10.3-16.9]; P=0.0053). CMRI demonstrated that atrial LGE was more severe in the AF group than in the SR group (AF, 7/7 [100%]; SR, 11/21 [52.4%]; P=0.00228). Univariate logistic regression analysis showed that average E/e' demonstrated significant association with AF in all patients (odds ratio 1.24; [95% confidence interval 1.03-1.51]; P=0.0251)., Conclusions: AF may be associated with atrial lesions and diastolic dysfunction in patients with CA., Competing Interests: The authors declare no conflicts of interest. K.M. is a member of Circulation Reports’ Editorial Team., (Copyright © 2024, THE JAPANESE CIRCULATION SOCIETY.)

Published
2024
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50. Polymorphic Ventricular Tachycardia Associated with Coronary Vasospasm in a Patient with Coronavirus Disease 2019 Infection.

Author

Gosho H, Kawano H, Otsuka K, Arakawa S, Takei A, Fukae S, Honda T, Yonekura T, Ikeda S, and Maemura K

Subjects
Humans, Male, Aged, Pandemics, Pneumonia, Viral complications, Pneumonia, Viral diagnosis, Coronavirus Infections complications, Coronavirus Infections diagnosis, Betacoronavirus, COVID-19 complications, Tachycardia, Ventricular etiology, Tachycardia, Ventricular diagnosis, Coronary Vasospasm complications, Coronary Vasospasm diagnostic imaging, Coronary Vasospasm diagnosis, Electrocardiography, SARS-CoV-2, Coronary Angiography
Abstract

A 70-year-old man was admitted to our hospital for restoration of sinus rhythm from atrial fibrillation by direct current counter shocks. On admission, he had a coronavirus disease 2019 (COVID-19) infection and syncope during bed rest. Electrocardiography revealed polymorphic ventricular tachycardia after ST-segment elevation with a normal QT interval. Coronary angiography revealed coronary vasospasm. Coronary vasospasm may be a cause of polymorphic ventricular tachycardia in COVID-19 patients.

Published
2024
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