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238 results on '"Fujiyama T"'

20. Type-1 polarised dendritic cells are a potent immunogen against Mycobacterium tuberculosis

Author

Satake, Y., primary, Nakamura, Y., additional, Kono, M., additional, Hozumi, H., additional, Nagata, T., additional, Tsujimura, K., additional, Enomoto, N., additional, Fujisawa, T., additional, Inui, N., additional, Fujiyama, T., additional, Tokura, Y., additional, Matsui, T., additional, Yokomura, K., additional, Shirai, M., additional, Hayakawa, H., additional, and Suda, T., additional

Published
2017
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30. Investigating use of space of pedestrians

Author

Fujiyama, T.

Subjects
use of space, pedestrians
Abstract

Understanding use of space of pedestrian is important to plan/design street environments or large public transport facilities. The purpose of a series of our research is to investigate use of space of various pedestrians in a variety of environmental situations. The research is a part of PAMELA project designed to test existing and proposed pedestrian environments and street facilities (i.e. a bus stop) under controlled conditions. This paper is aimed at setting out the background of the research, and presenting a basic frame work for subsequent research. Strength of our approach is the microscopic heterogeneous approach, where each walking person is regarded different from others. Relations among characteristics of pedestrians, characteristics of facilities/ environments, and resulting actions of pedestrians are carefully examined. Conclusion suggests directions of further research.

Published
2005

31. Pedestrian speeds on stairs: an initial step for a simulation model

Author

Fujiyama, T. and Tyler, N.

Subjects
Pedestrian, Walking speed, Stair, Elderly pedestrians, Leg extensor power (LEP), Stairgradient, Predicting walking speeds
Abstract

In order to predict a pedestrian’s walking speed on stairs from his/her characteristics of and those of the stairs, the relationship between the walking speed of a pedestrian on stairs and his/her characteristics, and the relationship between the pedestrians’ walking speeds on stairs and the stair-gradients were investigated. It is suggested that Leg Extensor Power shows a strong correlation to walking speeds of elderly people on stairs, the stair-gradient has a linear relationship with horizontal walking speeds on stairs, and Leg Extensor Power could be used to represent a unique walking speed of an elderly pedestrian on stairs.

Published
2004

44. Preferential infiltration of interleukin-4-producing CXCR4+ T cells in the lesional muscle but not skin of patients with dermatomyositis.

Author

Fujiyama, T., Ito, T., Ogawa, N., Suda, T., Tokura, Y., and Hashizume, H.

Subjects
*DERMATOMYOSITIS, *INTERLEUKIN-4, *CXCR4 receptors, *T cells, *MUSCLE cells, *GENE expression, *PATIENTS
Abstract

Dermatomyositis ( DM) and polymyositis ( PM) are collectively termed autoimmune myopathy. To investigate the difference between muscle- and skin-infiltrating T cells and to address their role for myopathy, we characterized T cells that were directly expanded from the tissues. Enrolled into this study were 25 patients with DM and three patients with PM. Muscle and skin biopsied specimens were immersed in c RPMI medium supplemented with interleukin ( IL)-2 and anti- CD3/ CD28 antibody-conjugated microbeads. The expanded cells were subjected to flow cytometry to examine their phenotypes. We analysed the cytokine concentration in the culture supernatants from the expanded T cells and the frequencies of cytokine-bearing cells by intracellular staining. There was non-biased in-vitro expansion of tissue-infiltrating CD4+ and CD8+ T cells from the muscle and skin specimens. The majority of expanded T cells were chemokine receptor ( CCR) type 7- CD45 RO+ effecter memory cells with various T cell receptor ( TCR) Vβs. The skin-derived but not muscle-derived T cells expressed cutaneous lymphocyte antigen ( CLA) and CCR10 and secreted large amounts of IL-17 A, suggesting that T helper type 17 ( Th17) cells may have a crucial role in the development of skin lesions. Notably, the frequency of IL-4-producing chemokine (C-X-C motif) receptor (CX CR)4+ Th2 cells was significantly higher in the muscle-derived cells and correlated inversely with the serum creatine phosphokinase (CPK) and lactate dehydrogenase ( LDH) levels. stromal-derived factor (SDF)-1/ CXCL12, a ligand for CXCR4, was expressed at a high level in the vascular endothelial cells between muscular fasciculi. Our study suggests that T cell populations in the muscle and skin are different, and the Th2 cell infiltrate in the muscle is associated with the low severity of myositis in DM. [ABSTRACT FROM AUTHOR]

Published
2014
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49. CD8+ Sézary syndrome with interleukin-22 production modulated by bacterial sepsis.

Author

Shimauchi, T., Sasada, K., Kito, Y., Mori, T., Hata, M., Fujiyama, T., Ito, T., Hirakawa, S., and Tokura, Y.

Subjects
EOSINOPHIL disorders, SERUM, ANTIBIOTICS, ABDOMEN, GROINS (Shore protection)
Abstract

A case study of 54-year-old Japanese woman presented with history of a pruritic, erythrodermic eruption with eosinophilia. Clinical examination showed that she had pigmented erythroderma with lymphoadenopathy on her groins. Patient was treated with systemic antibiotics and showed a higher serum level of interlukin (IL) 22

Published
2013
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