1,754 results on '"Fujiwara, Keiichi"'
Search Results
2. Prediction of response to promising first-line chemotherapy in ovarian cancer patients with residual peritoneal tumors: practical biomarkers and robust multiplex models
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Kawabata-Iwakawa, Reika, Iwasa, Norihiro, Satoh, Kenichi, Colinge, Jacques, Shimada, Muneaki, Takeuchi, Satoshi, Fujiwara, Hiroyuki, Eguchi, Hidetaka, Oishi, Tetsuro, Sugiyama, Toru, Suzuki, Mitsuaki, Hasegawa, Kosei, Fujiwara, Keiichi, and Nishiyama, Masahiko
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- 2024
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3. Integrated genomic/epigenomic analysis stratifies subtypes of clear cell ovarian carcinoma, highlighting their cellular origin
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Nishijima, Akira, Oda, Katsutoshi, Hasegawa, Kosei, Koso, Takahiro, Asada, Kayo, Ikeda, Yuji, Taguchi, Ayumi, Maeda, Daichi, Nagae, Genta, Tsuji, Shingo, Tatsuno, Kenji, Uehara, Yuriko, Kurosaki, Akira, Sato, Sho, Tanikawa, Michihiro, Sone, Kenbun, Mori, Mayuyo, Ikemura, Masako, Fujiwara, Keiichi, Ushiku, Tetsuo, Osuga, Yutaka, and Aburatani, Hiroyuki
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- 2024
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4. Association of D-dimer level with thrombotic events, bleeding, and mortality in Japanese patients with solid tumors: a Cancer-VTE Registry subanalysis
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Nakamura, Mashio, Sakon, Masato, Sasako, Mitsuru, Okusaka, Takuji, Mukai, Hirofumi, Fujiwara, Keiichi, Kunitoh, Hideo, Oba, Mari S., Wada, Hideo, Hosokawa, Jun, Takita, Atsushi, and Ikeda, Masataka
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- 2024
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5. Clinical characteristics of patients treated with immune checkpoint inhibitors in EGFR-mutant non-small cell lung cancer: CS-Lung-003 prospective observational registry study
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Kuribayashi, Tadahiro, Ohashi, Kadoaki, Nishii, Kazuya, Ninomiya, Kiichiro, Tsubata, Yukari, Ishikawa, Nobuhisa, Kodani, Masahiro, Kanaji, Nobuhiro, Yamasaki, Masahiro, Fujitaka, Kazunori, Kuyama, Shoichi, Takigawa, Nagio, Fujimoto, Nobukazu, Kubota, Tetsuya, Inoue, Masaaki, Fujiwara, Keiichi, Harita, Shingo, Takata, Ichiro, Takada, Kenji, Okawa, Sachi, Kiura, Katsuyuki, and Hotta, Katsuyuki
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- 2024
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6. Development of a Japanese Scale that Evaluates the Level of Nursing Support Provided to Patients for Decision-Making in Cancer Clinical Trials
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Kohara, Izumi, Fujiwara, Noriko, Tamaki, Shuko, Nakahama, Hiroko, Nosaki, Akiko, Hosoya, Miki, Yabuki, Midori, Yamamoto, Mayumi, Kojima, Chiemi, and Fujiwara, Keiichi
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- 2023
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7. Safety and efficacy of airway stent placement following bronchial artery embolization: A retrospective study at a single institute
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Takigawa, Yuki, Sato, Ken, Kudo, Kenichiro, Inoue, Tomoyoshi, Fujiwara, Miho, Matsuoka, Suzuka, Watanabe, Hiromi, Sato, Akiko, Mukai, Takashi, and Fujiwara, Keiichi
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- 2024
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8. Clinical evaluation of a low-coverage whole-genome test for detecting homologous recombination deficiency in ovarian cancer
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Boidot, Romain, Blum, Michael G.B., Wissler, Marie-Pierre, Gottin, Céline, Ruzicka, Jiri, Chevrier, Sandy, Delhomme, Tiffany M., Audoux, Jérome, Jeanniard, Adrien, Just, Pierre-Alexandre, Harter, Philipp, Pignata, Sandro, González-Martin, Antonio, Marth, Christian, Mäenpää, Johanna, Colombo, Nicoletta, Vergote, Ignace, Fujiwara, Keiichi, Duforet-Frebourg, Nicolas, Bertrand, Denis, Philippe, Nicolas, Ray-Coquard, Isabelle, and Pujade-Lauraine, Eric
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- 2024
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9. Potential of circulating receptor-interacting protein kinase 3 levels as a marker of acute liver injury
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Kondo, Takayuki, Fujimoto, Kentaro, Fujiwara, Kisako, Yumita, Sae, Ishino, Takamasa, Ogawa, Keita, Nakagawa, Miyuki, Iwanaga, Terunao, Koroki, Keisuke, Kanzaki, Hiroaki, Inoue, Masanori, Kobayashi, Kazufumi, Kiyono, Soichiro, Nakamura, Masato, Kanogawa, Naoya, Ogasawara, Sadahisa, Nakamoto, Shingo, Chiba, Tetsuhiro, Kato, Jun, Fujiwara, Keiichi, and Kato, Naoya
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- 2023
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10. Prognostic significance of ethnicity and age in advanced stage epithelial ovarian cancer: An NRG oncology/gynecologic oncology group study
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duPont, Nefertiti C, Enserro, Danielle, Brady, Mark F, Moxley, Katherine, Walker, Joan L, Cosgrove, Casey, Bixel, Kristin, Tewari, Krishnansu S, Thaker, Premal, Wahner Hendrickson, Andrea E, Rubin, Stephen, Fujiwara, Keiichi, Casey, A Catherine, Soper, John, Burger, Robert A, and Monk, Bradley J
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Reproductive Medicine ,Biomedical and Clinical Sciences ,Oncology and Carcinogenesis ,Cancer ,Ovarian Cancer ,Clinical Trials and Supportive Activities ,Clinical Research ,Rare Diseases ,Prevention ,Patient Safety ,Adenocarcinoma ,Black or African American ,Age Factors ,Aged ,Aged ,80 and over ,Angiogenesis Inhibitors ,Antineoplastic Combined Chemotherapy Protocols ,Asian ,Bevacizumab ,Carboplatin ,Carcinoma ,Endometrioid ,Carcinoma ,Ovarian Epithelial ,Chemotherapy ,Adjuvant ,Ethnicity ,Fallopian Tube Neoplasms ,Female ,Hispanic or Latino ,Humans ,Middle Aged ,Neoplasm Staging ,Neoplasms ,Cystic ,Mucinous ,and Serous ,Ovarian Neoplasms ,Paclitaxel ,Peritoneal Neoplasms ,Prognosis ,Proportional Hazards Models ,Survival Rate ,White People ,Minority populations ,Asian women ,African American women ,Elderly ,Ovarian cancer ,Paediatrics and Reproductive Medicine ,Oncology & Carcinogenesis ,Clinical sciences ,Oncology and carcinogenesis ,Reproductive medicine - Abstract
BackgroundAge and ethnicity are among several factors that influence overall survival (OS) in ovarian cancer. The study objective was to determine whether ethnicity and age were of prognostic significance in women enrolled in a clinical trial evaluating the addition of bevacizumab to front-line therapy.MethodsWomen with advanced stage ovarian, primary peritoneal, or fallopian tube cancer were enrolled in a phase III clinical trial. All women had surgical staging and received adjuvant chemotherapy with one of three regimens. Cox proportional hazards models were used to evaluate the relationship between OS with age and race/ethnicity among the study participants.ResultsOne-thousand-eight-hundred-seventy-three women were enrolled in the study. There were 280 minority women and 328 women over the age of 70. Women age 70 and older had a 34% increase risk for death when compared to women under 60 (HR = 1.34; 95% CI 1.16-1.54). Non-Hispanic Black women had a 54% decreased risk of death with the addition of maintenance bevacizumab (HR = 0.46, 95% CI:0.26-0.83). Women of Asian descent had more hematologic grade 3 or greater adverse events and a 27% decrease risk of death when compared to non-Hispanic Whites (HR = 0.73; 95% CI: 0.59-0.90).ConclusionsNon-Hispanic Black women showed a decreased risk of death with the addition of bevacizumab and patients of Asian ancestry had a lower death rate than all other minority groups, but despite these clinically meaningful improvements there was no statistically significant difference in OS among the groups.
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- 2022
11. More than one-third of advanced non-small-cell lung cancer patients do not receive immunochemotherapy due to intolerance
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Ando, Chihiro, Ichihara, Eiki, Yokoyama, Toshihide, Inoue, Koji, Tamura, Tomoki, Fujiwara, Keiichi, Oda, Naohiro, Kano, Hirohisa, Kishino, Daizo, Watanabe, Kazuhiko, Inoue, Masaaki, Ochi, Nobuaki, Onishi, Fumie, Ichikawa, Hirohisa, Kobe, Hiroshi, Tachibana, Sayaka, Hotta, Katsuyuki, Maeda, Yoshinobu, and Kiura, Katsuyuki
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- 2023
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12. Neoadjuvant chemotherapy followed by interval debulking surgery for advanced epithelial ovarian cancer: GOTIC-019 study
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Nagao, Shoji, Tamura, Jun, Shibutani, Takashi, Miwa, Maiko, Kato, Tomoyasu, Shikama, Ayumi, Takei, Yuji, Kamiya, Natsuko, Inoue, Naoki, Nakamura, Kazuto, Inoue, Aya, Yamamoto, Koji, Fujiwara, Keiichi, and Suzuki, Mitsuaki
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- 2023
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13. Association between financial toxicity and health-related quality of life of patients with gynecologic cancer
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Kajimoto, Yusuke, Honda, Kazunori, Suzuki, Shiro, Mori, Masahiko, Tsubouchi, Hirofumi, Nakao, Kohshiro, Azuma, Anri, Shibutani, Takashi, Nagao, Shoji, Koyanagi, Takahiro, Kohara, Izumi, Tamaki, Shuko, Yabuki, Midori, Teng, Lida, Fujiwara, Keiichi, and Igarashi, Ataru
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- 2023
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14. Efficacy of immune checkpoint inhibitor monotherapy in elderly patients with non-small-cell lung cancer
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Kubo, Toshio, Ichihara, Eiki, Harada, Daijiro, Inoue, Koji, Fujiwara, Keiichi, Hosokawa, Sinobu, Kishino, Daizo, Kawai, Haruyuki, Ochi, Nobuaki, Oda, Naohiro, Hara, Naofumi, Hotta, Katsuyuki, Tabata, Masahiro, Maeda, Yoshinobu, and Kiura, Katsuyuki
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- 2023
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15. Health-Related Quality of Life in Patients With Advanced Endometrial Cancer Treated With Lenvatinib Plus Pembrolizumab or Treatment of Physician’s Choice
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Lorusso, Domenica, Colombo, Nicoletta, Herraez, Antonio Casado, Santin, Alessandro D., Colomba, Emeline, Miller, David Scott, Fujiwara, Keiichi, Pignata, Sandro, Baron-Hay, Sally E., Ray-Coquard, Isabelle Laure, Shapira-Frommer, Ronnie, Kim, Yong Man, McCormack, Mary, Massaad, Rachid, Nguyen, Allison Martin, Zhao, Qi, McKenzie, Jodi, Prabhu, Vimalanand S., and Makker, Vicky
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- 2023
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16. Predictive Blood-Based Biomarkers in Patients with Epithelial Ovarian Cancer Treated with Carboplatin and Paclitaxel with or without Bevacizumab: Results from GOG-0218.
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Alvarez Secord, Angeles, Bell Burdett, Kirsten, Owzar, Kouros, Tritchler, David, Sibley, Alexander, Liu, Yingmiao, Starr, Mark, Brady, J, Lankes, Heather, Hurwitz, Herbert, Mannel, Robert, Tewari, Krishnansu, OMalley, David, Gray, Heidi, Bakkum-Gamez, Jamie, Fujiwara, Keiichi, Boente, Matthew, Deng, Wenbin, Burger, Robert, Birrer, Michael, and Nixon, Andrew
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Adult ,Aged ,Aged ,80 and over ,Antibodies ,Monoclonal ,Humanized ,Antineoplastic Combined Chemotherapy Protocols ,Bevacizumab ,Biomarkers ,Tumor ,Carboplatin ,Carcinoma ,Ovarian Epithelial ,Double-Blind Method ,Female ,Humans ,Interleukin-6 ,Middle Aged ,Ovarian Neoplasms ,Paclitaxel ,Survival Rate - Abstract
PURPOSE: GOG-0218, a double-blind placebo-controlled phase III trial, compared carboplatin and paclitaxel with placebo, bevacizumab followed by placebo, or bevacizumab followed by bevacizumab in advanced epithelial ovarian cancer (EOC). Results demonstrated significantly improved progression-free survival (PFS), but no overall survival (OS) benefit with bevacizumab. Blood samples were collected for biomarker analyses. EXPERIMENTAL DESIGN: Plasma samples were analyzed via multiplex ELISA technology for seven prespecified biomarkers [IL6, Ang-2, osteopontin (OPN), stromal cell-derived factor-1 (SDF-1), VEGF-D, IL6 receptor (IL6R), and GP130]. The predictive value of each biomarker with respect to PFS and OS was assessed using a protein marker by treatment interaction term within the framework of a Cox proportional hazards model. Prognostic markers were identified using Cox models adjusted for baseline covariates. RESULTS: Baseline samples were available from 751 patients. According to our prespecified analysis plan, IL6 was predictive of a therapeutic advantage with bevacizumab for PFS (P = 0.007) and OS (P = 0.003). IL6 and OPN were found to be negative prognostic markers for both PFS and OS (P < 0.001). Patients with high median IL6 levels (dichotomized at the median) treated with bevacizumab had longer PFS (14.2 vs. 8.7 months) and OS (39.6 vs. 33.1 months) compared with placebo. CONCLUSIONS: The inflammatory cytokine IL6 may be predictive of therapeutic benefit from bevacizumab when combined with carboplatin and paclitaxel. Aligning with results observed in patients with renal cancer treated with antiangiogenic therapies, it appears plasma IL6 may also define those patients with EOC more or less likely to benefit from the addition of bevacizumab to standard chemotherapy.
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- 2020
17. Predictive Blood-Based Biomarkers in Patients with Epithelial Ovarian Cancer Treated with Carboplatin and Paclitaxel with or without Bevacizumab: Results from GOG-0218
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Secord, Angeles Alvarez, Burdett, Kirsten Bell, Owzar, Kouros, Tritchler, David, Sibley, Alexander B, Liu, Yingmiao, Starr, Mark D, Brady, J Chris, Lankes, Heather A, Hurwitz, Herbert I, Mannel, Robert S, Tewari, Krishnansu S, O'Malley, David M, Gray, Heidi, Bakkum-Gamez, Jamie N, Fujiwara, Keiichi, Boente, Matthew, Deng, Wei, Burger, Robert A, Birrer, Michael J, and Nixon, Andrew B
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Clinical Trials and Supportive Activities ,Ovarian Cancer ,Rare Diseases ,Clinical Research ,Cancer ,Evaluation of treatments and therapeutic interventions ,6.1 Pharmaceuticals ,Adult ,Aged ,Aged ,80 and over ,Antibodies ,Monoclonal ,Humanized ,Antineoplastic Combined Chemotherapy Protocols ,Bevacizumab ,Biomarkers ,Tumor ,Carboplatin ,Carcinoma ,Ovarian Epithelial ,Double-Blind Method ,Female ,Humans ,Interleukin-6 ,Middle Aged ,Ovarian Neoplasms ,Paclitaxel ,Survival Rate ,Oncology and Carcinogenesis ,Oncology & Carcinogenesis - Abstract
PurposeGOG-0218, a double-blind placebo-controlled phase III trial, compared carboplatin and paclitaxel with placebo, bevacizumab followed by placebo, or bevacizumab followed by bevacizumab in advanced epithelial ovarian cancer (EOC). Results demonstrated significantly improved progression-free survival (PFS), but no overall survival (OS) benefit with bevacizumab. Blood samples were collected for biomarker analyses.Experimental designPlasma samples were analyzed via multiplex ELISA technology for seven prespecified biomarkers [IL6, Ang-2, osteopontin (OPN), stromal cell-derived factor-1 (SDF-1), VEGF-D, IL6 receptor (IL6R), and GP130]. The predictive value of each biomarker with respect to PFS and OS was assessed using a protein marker by treatment interaction term within the framework of a Cox proportional hazards model. Prognostic markers were identified using Cox models adjusted for baseline covariates.ResultsBaseline samples were available from 751 patients. According to our prespecified analysis plan, IL6 was predictive of a therapeutic advantage with bevacizumab for PFS (P = 0.007) and OS (P = 0.003). IL6 and OPN were found to be negative prognostic markers for both PFS and OS (P < 0.001). Patients with high median IL6 levels (dichotomized at the median) treated with bevacizumab had longer PFS (14.2 vs. 8.7 months) and OS (39.6 vs. 33.1 months) compared with placebo.ConclusionsThe inflammatory cytokine IL6 may be predictive of therapeutic benefit from bevacizumab when combined with carboplatin and paclitaxel. Aligning with results observed in patients with renal cancer treated with antiangiogenic therapies, it appears plasma IL6 may also define those patients with EOC more or less likely to benefit from the addition of bevacizumab to standard chemotherapy.
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- 2020
18. Secondary Surgical Cytoreduction for Recurrent Ovarian Cancer.
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Coleman, Robert, Spirtos, Nick, Enserro, Danielle, Herzog, Thomas, Sabbatini, Paul, Armstrong, Deborah, Kim, Jae-Weon, Park, Sang-Yoon, Kim, Byoung-Gie, Nam, Joo-Hyun, Fujiwara, Keiichi, Walker, Joan, Casey, Ann, Alvarez Secord, Angeles, Rubin, Steve, Chan, John, DiSilvestro, Paul, Davidson, Susan, Cohn, David, Basen-Engquist, Karen, Huang, Helen, Brady, Mark, Mannel, Robert, and Tewari, Krishnansu
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Aged ,Antineoplastic Combined Chemotherapy Protocols ,Bevacizumab ,Carboplatin ,Combined Modality Therapy ,Cytoreduction Surgical Procedures ,Female ,Humans ,Middle Aged ,Neoplasm Recurrence ,Local ,Neoplasms ,Glandular and Epithelial ,Ovarian Neoplasms ,Paclitaxel ,Quality of Life ,Reoperation ,Survival Analysis - Abstract
BACKGROUND: Secondary surgical cytoreduction in women with platinum-sensitive, recurrent epithelial ovarian, primary peritoneal, or fallopian-tube (ovarian) cancer is widely practiced but has not been evaluated in phase 3 investigation. METHODS: We randomly assigned patients with recurrent ovarian cancer who had received one previous therapy, had an interval during which no platinum-based chemotherapy was used (platinum-free interval) of 6 months or more, and had investigator-determined resectable disease (to no macroscopic residual disease) to undergo secondary surgical cytoreduction and then receive platinum-based chemotherapy or to receive platinum-based chemotherapy alone. Adjuvant chemotherapy (paclitaxel-carboplatin or gemcitabine-carboplatin) and use of bevacizumab were at the discretion of the investigator. The primary end point was overall survival. RESULTS: A total of 485 patients underwent randomization, 240 to secondary cytoreduction before chemotherapy and 245 to chemotherapy alone. The median follow-up was 48.1 months. Complete gross resection was achieved in 67% of the patients assigned to surgery who underwent the procedure. Platinum-based chemotherapy with bevacizumab followed by bevacizumab maintenance was administered to 84% of the patients overall and was equally distributed between the two groups. The hazard ratio for death (surgery vs. no surgery) was 1.29 (95% confidence interval [CI], 0.97 to 1.72; P = 0.08), which corresponded to a median overall survival of 50.6 months and 64.7 months, respectively. Adjustment for platinum-free interval and chemotherapy choice did not alter the effect. The hazard ratio for disease progression or death (surgery vs. no surgery) was 0.82 (95% CI, 0.66 to 1.01; median progression-free survival, 18.9 months and 16.2 months, respectively). Surgical morbidity at 30 days was 9%; 1 patient (0.4%) died from postoperative complications. Patient-reported quality of life decreased significantly after surgery but did not differ significantly between the two groups after recovery. CONCLUSIONS: In this trial involving patients with platinum-sensitive, recurrent ovarian cancer, secondary surgical cytoreduction followed by chemotherapy did not result in longer overall survival than chemotherapy alone. (Funded by the National Cancer Institute and others; GOG-0213 ClinicalTrials.gov number, NCT00565851.).
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- 2019
19. Randomized phase II trial of farletuzumab plus chemotherapy versus placebo plus chemotherapy in low CA-125 platinum-sensitive ovarian cancer
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Herzog, Thomas J., Pignata, Sandro, Ghamande, Sharad A., Rubio, Maria-Jesús, Fujiwara, Keiichi, Vulsteke, Christof, Armstrong, Deborah K., Sehouli, Jalid, Coleman, Robert L., Gabra, Hani, Scambia, Giovanni, Monk, Bradley J., Arranz, José A., Ushijima, Kimio, Hanna, Rabbie, Zamagni, Claudio, Wenham, Robert M., González-Martín, Antionio, Slomovitz, Brian, Jia, Yan, Ramsay, Lisa, Tewari, Krishnansu S., Weil, Susan C., and Vergote, Ignace B.
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- 2023
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20. Final safety results from ATHENA–MONO (GOG-3020/ENGOT-ov45), a randomized, placebo-controlled, double-blind, phase 3 trial evaluating rucaparib monotherapy as maintenance treatment in patients with newly diagnosed ovarian cancer.
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O'Malley, David M., primary, Monk, Bradley J., additional, Lim, Myong Cheol, additional, Fuentes Pradera, Jose, additional, Buscema, Joseph, additional, Wilson, Michelle K., additional, De Vivo, Rocco, additional, Herzog, Thomas J., additional, Zagouri, Flora, additional, Oza, Amit M., additional, Mikheeva, Olga N., additional, Diaz, John Paul, additional, Lisyanskaya, Alla Sergeevna, additional, Morris, Robert, additional, Bruchim, Ilan, additional, Craib, Marcia, additional, Connor, Christy, additional, Shih, Danny, additional, Fujiwara, Keiichi, additional, and Kristeleit, Rebecca, additional
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- 2024
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21. Tisotumab vedotin in 2L/3L recurrent or metastatic cervical cancer: Subsequent therapy data from ENGOT-cx12/GOG-3057/innovaTV 301.
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Manso, Luis, primary, Vergote, Ignace, additional, Fujiwara, Keiichi, additional, Angelergues, Antoine, additional, Zikan, Michal, additional, Jordan, Scott, additional, Lee, Jung-Yun, additional, Barraclough, Lisa, additional, Maluf, Fernando Cotait, additional, Lorusso, Domenica, additional, Yonemori, Kan, additional, Gennigens, Christine, additional, Gonzalez Martin, Antonio, additional, Heitz, Florian, additional, Westermann, Anneke M., additional, Covens, Allan, additional, Whalley, Elizabeth, additional, Chen, Yiyi, additional, Soumaoro, Ibrahima, additional, and Randall, Leslie M., additional
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- 2024
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22. Airway stenosis secondary to mediastinal lymph node metastasis of lung adenocarcinoma treated with AERO stent and osimertinib: A case report
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Takigawa, Yuki, primary, Sato, Ken, additional, Inoue, Tomoyoshi, additional, Sato, Akiko, additional, Furutaguchi, Yui, additional, Goda, Mayu, additional, Shiraha, Keisuke, additional, Fujiwara, Miho, additional, Matsuoka, Suzuka, additional, Mitsumune, Sho, additional, Watanabe, Hiromi, additional, Kudo, Kenichiro, additional, Fujiwara, Keiichi, additional, and Shibayama, Takuo, additional
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- 2024
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23. Real-World Data Analysis of Pembrolizumab Monotherapy for NSCLC Using Japanese Postmarketing All-Case Surveillance Data
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Terai, Hideki, Soejima, Kenzo, Shimokawa, Asanao, Horinouchi, Hidehito, Shimizu, Junichi, Hase, Tetsunari, Kanemaru, Ryota, Watanabe, Kana, Ninomiya, Kiichiro, Aragane, Naoko, Yanagitani, Noriko, Sakata, Yoshihiko, Seike, Masahiro, Fujimoto, Daichi, Kasajima, Masashi, Kubo, Akihito, Kusumoto, Sojiro, Oyamada, Yoshitaka, Fujiwara, Keiichi, Mori, Masahide, Hashimoto, Midori, Shingyoji, Masato, Kodani, Masahiro, Sakamoto, Jin, Agatsuma, Toshihiko, Kashiwabara, Kosuke, Inomata, Minehiko, Tachihara, Motoko, Tanaka, Kazuhisa, Hayashihara, Kenji, Koyama, Nobuyuki, Matsui, Kaoru, Minato, Koichi, Jingu, Daisuke, Sakashita, Hiroyuki, Hara, Satoshi, Naito, Tomoyuki, Okada, Asuka, Tanahashi, Masayuki, Sato, Yuki, Asano, Koichiro, Takeda, Takayuki, Nakazawa, Kensuke, Harada, Toshiyuki, Shibata, Kazuhiko, Kato, Tatsuo, Miyaoka, Etsuo, Yoshino, Ichiro, Gemma, Akihiko, and Mitsudomi, Tetsuya
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- 2022
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24. Randomized Trial of Intravenous Versus Intraperitoneal Chemotherapy Plus Bevacizumab in Advanced Ovarian Carcinoma: An NRG Oncology/Gynecologic Oncology Group Study.
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Walker, Joan, Brady, Mark, Fleming, Gini, Huang, Helen, DiSilvestro, Paul, Fujiwara, Keiichi, Alberts, David, Zheng, Wenxin, Cohn, David, Powell, Matthew, Van Le, Linda, Davidson, Susan, Gray, Heidi, Rose, Peter, Aghajanian, Carol, Myers, Tashanna, Alvarez Secord, Angeles, Rubin, Stephen, Mannel, Robert, Wenzel, Lari, and Tewari, Krishnansu
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Adult ,Aged ,Aged ,80 and over ,Antineoplastic Combined Chemotherapy Protocols ,Bevacizumab ,Carboplatin ,Disease Progression ,Drug Administration Schedule ,Female ,Humans ,Infusions ,Intravenous ,Infusions ,Parenteral ,Middle Aged ,Neoplasm Staging ,Ovarian Neoplasms ,Paclitaxel ,Progression-Free Survival ,Time Factors ,United States - Abstract
PURPOSE: To evaluate the impact of two different intraperitoneal (IP) chemotherapy regimens on progression-free survival (PFS) among women with newly diagnosed advanced ovarian carcinoma. METHODS: Eligible patients were randomly assigned to six cycles of IV paclitaxel 80 mg/m2 once per week with intravenous (IV) carboplatin area under the curve 6 (IV carboplatin) versus IV paclitaxel 80 mg/m2 once per week with IP carboplatin area under the curve 6 (IP carboplatin) versus once every 3 weeks IV paclitaxel 135 mg/m2 over 3 hours day 1, IP cisplatin 75 mg/m2 day 2, and IP paclitaxel 60 mg/m2 day 8 (IP cisplatin). All participants received bevacizumab 15 mg/kg IV every 3 weeks in cycles 2 to 22. RESULTS: A total of 1,560 participants were enrolled and had 84.8 months of follow-up. The median PFS duration was 24.9 months in the IV carboplatin arm, 27.4 months in the IP carboplatin arm, and 26.2 months in the IP cisplatin arm. For the subgroup of 1,380 patients with stage II/III and residual disease of 1 cm or less, median PFS was 26.9 (IV-carboplatin), 28.7 (IP-carboplatin), and 27.8 months (IP cisplatin), respectively. Median PFS for patients with stage II/III and no residual disease was 35.9, 38.8, and 35.5 months, respectively. Median overall survival for all enrolled was 75.5, 78.9, and 72.9 months, respectively, and median overall survival for stage II/III with no gross residual disease was 98.8 months, 104.8 months, and not reached. Mean patient-reported Functional Assessment of Cancer Therapy neurotoxicity scores (Gynecologic Oncology Group) were similar for all arms, but the mean Trial Outcome Index of the Functional Assessment of Cancer Therapy-Ovary scores during chemotherapy were statistically worse in the IP cisplatin arm. CONCLUSION: Compared with the IV carboplatin reference arm, the duration of PFS was not significantly increased with either IP regimen when combined with bevacizumab and was better tolerated than IP cisplatin.
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- 2019
25. Clinical research in ovarian cancer: consensus recommendations from the Gynecologic Cancer InterGroup
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Mahner, Sven, Reuss, Alexander, du Bois, Andreas, Grimm, Christoph, Marth, Christian, Berger, Regina, Concin, Nicole, Chang, Ting-Chang, Ochiai, Kazunori, Gebski, Val, Davis, Alison, Beale, Philip, Vergote, Ignace, Kridelka, Frédéric, Denys, Hannelore, Vandecaveye, Vincent, Candido dos Reis, Francisco Jose, Del Pilar Estevez Diz, Maria, Stuart, Gavin, MacKay, Helen, Carey, Mark, Cibula, David, Dundr (path), Pavel, Dorigo, Oliver, Berek, Jonathan, O'Donnell, Dearbhaile, Saadeh, Abu, Boere, Ingrid, Lok, Christianne, Coronado, Pluvio, Ottevanger, Nelleke, Tan, David SP, Ng, Joseph, Gonzalez Martin, Antonio, Oaknin, Ana, Poveda, Andres, Perez Fidalgo, Alejandro, Rauh-Hain, Alejandro, Lu, Karen, López-Zavala, Carlos, Gómez-García, Eva María, Ray-Coquard, Isabelle, Paoletti, Xavier, Kurtz, Jean-Emmanuel, Joly, Florence, Votan, Bénédicte, Bookman, Michael, Moore, Kathleen, Arend, Rebecca, Fujiwara, Keiichi, Fujiwara, Hiroyuki, Hasegawa, Kosei, Bruchim, Ilan, Tsoref, Dalia, Oda, Katsutoshi, Okamoto, Aikou, Enomoto, Takayuki, Michel, Dayana, Kim, Hee-Seung, Lee, Jung-Yun, Mukhopadhyay, Asima, Katsaros, Dionyssios, Colombo, Nicoletta, Pignata, Sandro, Lorusso, Domenica, Scambia, Giovanni, Kohn, Elise, Lee, Jung-Min, McNeish, Iain, Nicum, Shibani, Farrelly, Laura, Sehouli, Jalid, Keller, Maren, Braicu, Elena, Bjørge, Line, Mirza, Mansoor Raza, Auranen, Annika, Welch, Stephen, Oza, Amit M, Heinzelmann, Viola, Gourley, Charlie, Roxburgh, Patricia, Herrington, C Simon, Glasspool, Ros, Zang, Rongyu, Zhu, Jianqing, Gonzalez-Martin, Antonio, Kohn, Elise C, Berek, Jonathan S, Tan, David S P, Stuart, Gavin C E, and Bookman, Michael A
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- 2022
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26. Modifiers of the Risk of Diabetes for Long-Term Outcomes After Coronary Revascularization: CREDO-Kyoto PCI/CABG Registry
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Kimura, Takeshi, Shiomi, Hiroki, Matsuda, Mitsuo, Takeuchi, Yuzo, Mitsuoka, Hirokazu, Uegaito, Takashi, Nakagawa, Yoshihisa, Tamura, Toshihiro, Konishi, Takashi, Ootani, Seiji, Fujiwara, Hisayoshi, Takatsu, Yoshiki, Sato, Yukihito, Taniguchi, Ryoji, Kataoka, Kazuaki, Inoko, Moriaki, Nohara, Ryuji, Nakano, Kimisato, Miyamoto, Syoichi, Kunihiko, Nagai, Murakami, Tomoyuki, Takeda, Teruki, Ishida, Katsuya, Nobuyoshi, Masakiyo, Yamaji, Kyohei, Yasumoto, Hitoshi, Iwabuchi, Masashi, Ando, Kenji, Domei, Takenori, Kato, Masayuki, Tatami, Ryozo, Shirotani, Manabu, Hattori, Ryuichi, Kita, Toru, Furukawa, Yutaka, Ehara, Natsuhiko, Kihara, Yasuki, Eizawa, Hiroshi, Kato, Hiroshi, Ishii, Katsuhisa, Aoyama, Takeshi, Sakurai, Takahiro, Kawanami, Masaki, Suyama, Tamaki, Tada, Eiji, Tanaka, Masaru, Inada, Tsukasa, Uzui, Hiroyasu, Nakano, Akira, Lee, Jong-Dae, Onodera, Tomoya, Takizawa, Akinori, Ryuzo, Nawada, Shinoda, Eiji, Takahashi, Masaaki, Yamada, Miho, Horie, Minoru, Yamamoto, Takashi, Takashima, Hiroyuki, Sakai, Hiroshi, Tamura, Takashi, Toyofuku, Mamoru, Kotoura, Hajime, Miura, Akira, Takahashi, Mamoru, Matoba, Yoshiki, Takumi, Takuro, Tei, Chuwa, Hamasaki, Shuichi, Doi, Osamu, Kambara, Hirofumi, Kaburagi, Satoshi, Sakamoto, Hiroki, Tada, Tomohisa, Mitsudo, Kazuaki, Kadota, Kazushige, Tada, Takeshi, Miki, Shinji, Mizoguchi, Tetsu, Akira, Yoshida, Kaneda, Kazuhisa, Ogawa, Hisao, Sugamura, Koichi, Sugiyama, Seigo, Doyama, Kiyoshi, Araki, Makoto, Suwa, Satoru, Sakata, Ryuzo, Ikeda, Tadashi, Marui, Akira, Minatoya, Kenji, Yamazaki, Kazuhiro, Onoe, Masahiko, Ogawa, Tatsuya, Yamanaka, Kazuo, Iwakura, Atsushi, Ohno, Nobuhisa, Fujiwara, Keiichi, Hanyu, Michiya, Soga, Kinji, Matsushita, Tsutomu, Nishiwaki, Noboru, Yoshida, Yuichi, Tamura, Nobushige, Okada, Yukikatsu, Nasu, Michihiro, Koyama, Tadaaki, Nakayama, Shogo, Tanaka, Kuniyoshi, Koshiji, Takaaki, Morioka, Koichi, Shimamoto, Mitsuomi, Yamazaki, Fumio, Terai, Yasuhiko, Nishizawa, Junichiro, Aota, Masaki, Kanemitsu, Naoki, Hara, Hiroyuki, Tabata, Takafumi, Imoto, Yutaka, Yamamoto, Hiroyuki, Matsuda, Katsuhiko, Nara, Masafumi, Tsuneyoshi, Hiroshi, Komiya, Tatsuhiko, Nakajima, Hiroyuki, Esaki, Jiro, Kawasuji, Michio, Moriyama, Syuji, Tambara, Keiichi, Arimura, Sakiko, Fujino, Yumika, Hanazawa, Miya, Hibi, Chikako, Kato, Risa, Kinoshita, Yui, Kitagawa, Kumiko, Kitamura, Masayo, Kuwahara, Takahiro, Sachiko, Maeda, Miki, Izumi, Minematsu, Saeko, Nishida, Satoko, Okamoto, Naoko, Saeki, Asuka, Sasae, Hitomi, Sato, Yuki, Takahashi, Asuka, Takinami, Emi, Tezuka, Saori, Tsuda, Marina, Tsumori, Miyuki, Uchida, Yuriko, Yamamoto, Yuko, Yamauchi, Misato, Yamazaki, Itsuki, Yoshimoto, Mai, Abe, Mitsuru, Fuki, Masayuki, Hayano, Mamoru, Kato, Eri, Kato, Yoshihiro, Matsumura-Nakano, Yukiko, Nakajima, Tetsu, Nakatsuma, Kenji, Natsuaki, Masahiro, Takeji, Yasuaki, Tazaki, Junichi, Tokushige, Akihiro, Watanabe, Hiroki, Yaku, Hidenori, Yamamoto, Erika, Yamamoto, Ko, Yamashita, Yugo, Yoshikawa, Yusuke, Morimoto, Takeshi, Kato, Eri T., Imada, Kazuaki, Nishikawa, Ryusuke, Mabuchi, Hiroshi, and Soga, Yoshiharu
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- 2022
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27. Association between effector-type regulatory T cells and immune checkpoint expression on CD8+ T cells in malignant ascites from epithelial ovarian cancer
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Sato, Sho, Matsushita, Hirokazu, Shintani, Daisuke, Kobayashi, Yukari, Fujieda, Nao, Yabuno, Akira, Nishikawa, Tadaaki, Fujiwara, Keiichi, Kakimi, Kazuhiro, and Hasegawa, Kosei
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- 2022
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28. Clinical significance of metabolism-related genes and FAK activity in ovarian high-grade serous carcinoma
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Sato, Masakazu, Sato, Sho, Shintani, Daisuke, Hanaoka, Mieko, Ogasawara, Aiko, Miwa, Maiko, Yabuno, Akira, Kurosaki, Akira, Yoshida, Hiroyuki, Fujiwara, Keiichi, and Hasegawa, Kosei
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- 2022
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29. Successful treatment of tracheal stenosis due to a broken uncovered metallic stent placed over 20 years ago in a patient with recurrent polychondritis using argon plasma coagulation and airway ballooning.
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Takigawa, Yuki, Sato, Ken, Kudo, Kenichiro, Ichikawa, Takeru, Sasano, Yuto, Matsumoto, Shoichiro, Inoue, Tomoyoshi, Fujiwara, Miho, Matsuoka, Suzuka, Watanabe, Hiromi, Sato, Akiko, Fujiwara, Keiichi, and Shibayama, Takuo
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ELECTROCOAGULATION (Medicine) ,TRACHEAL stenosis ,TREATMENT effectiveness ,AIRWAY (Anatomy) ,BRONCHI - Abstract
A woman in her mid‐60s with recurrent polychondritis was admitted to our hospital due to airway stenosis secondary to an uncovered metallic stent. She underwent a bronchoscopic intervention under general anaesthesia. During the procedure, the stent fracture was cauterized using Argon Plasma Coagulation (APC) cauterisation, performed with argon flow at 1 L/min and power set at 70 W. APC cauterisation caused the stent wire to flex circularly, gradually improving the stenosis. Tracheal dilatation was then performed using an airway balloon. Following the ballooning, a thin bronchoscope was easily passed through the lower trachea, and the left and right main bronchi were observed; therefore, the procedure was completed without any complications. APC coagulation and airway ballooning are viable choices for the temporary treatment of airway stenosis due to broken metallic stents. [ABSTRACT FROM AUTHOR]
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- 2024
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30. Recent advances in hepatitis E virus research and the Japanese clinical practice guidelines for hepatitis E virus infection.
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Kanda, Tatsuo, Li, Tian‐Cheng, Takahashi, Masaharu, Nagashima, Shigeo, Primadharsini, Putu Prathiwi, Kunita, Satoshi, Sasaki‐Tanaka, Reina, Inoue, Jun, Tsuchiya, Atsunori, Nakamoto, Shingo, Abe, Ryuzo, Fujiwara, Keiichi, Yokosuka, Osamu, Suzuki, Ryosuke, Ishii, Koji, Yotsuyanagi, Hiroshi, Okamoto, Hiroaki, Totsuka, Mai, Honda, Masayuki, and Arima, Shuhei
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HEPATITIS E virus ,NUCLEIC acid amplification techniques ,CHRONIC active hepatitis ,HEPATITIS E ,WILD boar - Abstract
Acute hepatitis E was considered rare until reports emerged affirming the existence of hepatitis E virus (HEV) genotypes 3 and 4 infections in Japan in the early 2000s. Extensive studies by Japanese researchers have highlighted the pivotal role of pigs and wild animals, such as wild boars and deer, as reservoirs for HEV, linking them to zoonotic infections in Japan. Currently, when hepatitis occurs subsequent to the consumption of undercooked or grilled pork, wild boar meat, or offal (including pig liver and intestines), HEV infection should be considered. Following the approval of anti‐HEV immunoglobulin A antibody as a diagnostic tool for hepatitis E by Japan's Health Insurance System in 2011, the annual number of diagnosed cases of HEV infection has surged. Notably, the occurrence of post‐transfusion hepatitis E promoted nationwide screening of blood products for HEV using nucleic acid amplification tests since 2020. Furthermore, chronic hepatitis E has been observed in immunosuppressed individuals. Considering the significance of hepatitis E, heightened preventive measures are essential. The Japan Agency for Medical Research and Development Hepatitis A and E viruses (HAV and HEV) Study Group, which includes special virologists and hepatologists, held a virtual meeting on February 17, 2024. Discussions encompassed pathogenesis, transmission routes, diagnosis, complications, severity factors, and ongoing and prospective vaccination or treatments for hepatitis E. Rigorous assessment of referenced studies culminated in the formulation of recommendations, which are detailed within this review. This comprehensive review presents recent advancements in HEV research and Japanese clinical practice guidelines for HEV infection. [ABSTRACT FROM AUTHOR]
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- 2024
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31. Successful treatment of type B2 thymoma with steroid and radiotherapy.
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Fujiwara, Miho, Watanabe, Hiromi, Takigawa, Yuki, Goda, Mayu, Shiraha, Keisuke, Inoue, Tomoyoshi, Matsuoka, Suzuka, Kudo, Kenichiro, Sato, Akiko, Sato, Ken, Fujiwara, Keiichi, and Shibayama, Takuo
- Subjects
NEEDLE biopsy ,THYMOMA ,TREATMENT effectiveness ,RADIOTHERAPY ,STEROIDS - Abstract
An 86‐year‐old woman with leg edema and dyspnea on exertion was admitted to our hospital. Chest computed tomography (CT) revealed a mass in the anterior mediastinum with pericardial invasion. Histological examination with endobronchial ultrasound‐guided transbronchial needle aspiration (EBUS‐TBNA) led to the diagnosis of Masaoka stage IVa type B2 thymoma. For palliation, radiotherapy (32 Gy/16 fractions) and prednisolone (30 mg/day) were administered and tapered. After treatment, both the pericardial effusion and tumour size decreased. Combination therapy with steroids and radiotherapy may be effective for treating thymomas. [ABSTRACT FROM AUTHOR]
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- 2024
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32. Significance of PD-L1 expression in the cytological samples of non-small cell lung cancer patients treated with immune checkpoint inhibitors
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Hara, Naofumi, Ichihara, Eiki, Harada, Daijiro, Inoue, Koji, Fujiwara, Keiichi, Hosokawa, Shinobu, Kishino, Daizo, Haruyuki, Kawai, Ochi, Nobuaki, Oda, Naohiro, Hotta, Katsuyuki, Maeda, Yoshinobu, and Kiura, Katsuyuki
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- 2021
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33. Correlation between Surgeons assessment and radiographic evaluation of residual disease in women with advanced stage ovarian cancer reported to have undergone optimal surgical cytoreduction: An NRG Oncology/Gynecologic Oncology Group study.
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Eskander, Ramez, Kauderer, James, Mannel, Robert, OMalley, David, Rubin, Stephen, Glaser, Gretchen, Hamilton, Chad, Fujiwara, Keiichi, Huh, Warner, Ueland, Frederick, Stephan, Jean-Marie, Burger, Robert, Tewari, Krishnansu, and Bristow, Robert
- Subjects
GOG ,NRG ,Ovarian cancer ,Radiographic evaluation ,Surgeons assessment ,Surgical cytoreduction ,Adult ,Aged ,Aged ,80 and over ,Antineoplastic Combined Chemotherapy Protocols ,Bevacizumab ,Carboplatin ,Carcinoma ,Ovarian Epithelial ,Cytoreduction Surgical Procedures ,Female ,Humans ,Middle Aged ,Neoplasm Grading ,Neoplasm Staging ,Neoplasm ,Residual ,Neoplasms ,Glandular and Epithelial ,Ovarian Neoplasms ,Paclitaxel ,Young Adult - Abstract
PURPOSE: We sought to determine the level of concordance among surgeons assessment of residual disease (RD) and pre-treatment computed tomography (CT) findings among women who underwent optimal surgical cytoreduction for advanced stage ovarian cancer. METHODS: This is a post-trial ad hoc analysis of a phase 3 randomized clinical trial evaluating the impact of bevacizumab in primary and maintenance therapy for patients with advanced stage ovarian cancer following surgical cytoreduction. All subjects underwent imaging of the chest/abdomen/pelvis to establish a post-surgical baseline prior to the initiation of chemotherapy. Information collected on trial was utilized to compare surgeons operative assessment of RD, to pre-treatment imaging. RESULTS: Of 1873 enrolled patients, surgical outcome was described as optimal (RD≤1cm) in 639 subjects. Twelve patients were excluded as they did not have a baseline, pretreatment imaging, leaving 627 participants for analysis. The average interval from surgery to baseline scan was 26days (range: 1-109). In 251 cases (40%), the post-operative scan was discordant with surgeon assessment, demonstrating RD>1cm in size. RD>1cm was most commonly identified in the right upper quadrant (28.4%), retroperitoneal para-aortic lymph nodes (RD>1.5cm; 28.2%) and the left upper quadrant (10.7%). Patients with RD>1cm on pre-treatment CT (discordant) exhibited a significantly greater risk of disease progression (HR 1.30; 95% CI 1.08-1.56; p=0.0059). CONCLUSIONS: Among patients reported to have undergone optimal cytoreduction, 40% were found to have lesions >1cm on postoperative, pretreatment imaging. Although inflammatory changes and/or rapid tumor regrowth could account for the discordance, the impact on PFS and distribution of RD may suggest underestimation by the operating surgeon.
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- 2018
34. A Case of Lung Metastasis of Breast Cancer Diagnosed Using Ultrathin Bronchoscopic Cryobiopsy with a "Tube-wedging Method"
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Takigawa, Yuki, primary, Watanabe, Hiromi, additional, Sato, Ken, additional, Matsuoka, Suzuka, additional, Kudo, Kenichiro, additional, Sato, Akiko, additional, Isoda, Tetsuya, additional, Shinno, Yoko, additional, Fujiwara, Keiichi, additional, and Shibayama, Takuo, additional
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- 2024
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35. Improved Bronchial Tree Image Reconstruction from the Lateral Decubitus Position of Computed Tomography Images for Virtual Navigation: A Case Report
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Takigawa, Yuki, primary, Miyake, Kotaro, additional, Sato, Ken, additional, Fujiwara, Keiichi, additional, Shiraha, Keisuke, additional, Inoue, Tomoyoshi, additional, Fujiwara, Miho, additional, Matsuoka, Suzuka, additional, Watanabe, Hiromi, additional, Kudo, Kenichiro, additional, Sato, Akiko, additional, Watanabe, Yuji, additional, and Shibayama, Takuo, additional
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- 2024
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36. Image of a thawed frozen specimen obtained using a cryoprobe floated with oil droplets in normal saline: An endobronchial lipomatous hamartoma image
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Takigawa, Yuki, primary, Sato, Ken, additional, Inoue, Tomoyoshi, additional, Takada, Masahiro, additional, and Fujiwara, Keiichi, additional
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- 2024
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37. Large‐vessel vasculitis induced by pegfilgrastim and immune checkpoint inhibitor in a patient with small‐cell lung cancer
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Shiraha, Keisuke, primary, Takigawa, Yuki, additional, Sato, Akiko, additional, Fujiwara, Keiichi, additional, Matsuo, Yuka, additional, Goda, Mayu, additional, Inoue, Tomoyoshi, additional, Nakamura, Eri, additional, Fujiwara, Miho, additional, Matsuoka, Suzuka, additional, Watanabe, Hiromi, additional, Kudo, Kenichiro, additional, Sato, Ken, additional, and Shibayama, Takuo, additional
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- 2024
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38. Effect of COVID-19 pandemic lockdowns on planned cancer surgery for 15 tumour types in 61 countries: an international, prospective, cohort study
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Glasbey, James, Ademuyiwa, Adesoji, Adisa, Adewale, AlAmeer, Ehab, Arnaud, Alexis P, Ayasra, Faris, Azevedo, José, Minaya-Bravo, Ana, Costas-Chavarri, Ainhoa, Edwards, John, Elhadi, Muhammed, Fiore, Marco, Fotopoulou, Christina, Gallo, Gaetano, Ghosh, Dhruva, Griffiths, Ewen A, Harrison, Ewen, Hutchinson, Peter, Lawani, Ismail, Lawday, Samuel, Lederhuber, Hans, Leventoglu, Sezai, Li, Elizabeth, Gomes, Gustavo Mendonça Ataíde, Mann, Harvinder, Marson, Ella J, Martin, Janet, Mazingi, Dennis, McLean, Kenneth, Modolo, Maria, Moore, Rachel, Morton, Dion, Ntirenganya, Faustin, Pata, Francesco, Picciochi, Maria, Pockney, Peter, Ramos-De la Medina, Antonio, Roberts, Keith, Roslani, April Camilla, Kottayasamy Seenivasagam, Rajkumar, Shaw, Richard, Simões, Joana Filipa Ferreira, Smart, Neil, Stewart, Grant D, Sullivan, Richard, Sundar, Sudha, Tabiri, Stephen, Taylor, Elliott H, Vidya, Raghavan, Nepogodiev, Dmitri, Bhangu, Aneel, Glasbey, James C, Bhangu, Aneel A, Siaw-Acheampong, Kwabena, Benson, Ruth A, Bywater, Edward, Chaudhry, Daoud, Dawson, Brett E, Evans, Jonathan P, Gujjuri, Rohan R, Heritage, Emily, Jones, Conor S, Kamarajah, Sivesh K, Khatri, Chetan, Khaw, Rachel A, Keatley, James M, Knight, Andrew, Mann, Harvinder S, McLean, Kenneth A, Mckay, Siobhan C, Mills, Emily C, Pellino, Gianluca, Tiwari, Abhinav, Simoes, Joana FF, Trout, Isobel M, Venn, Mary L, Wilkin, Richard JW, Smart, Neil J, Moug, Susan, Di Saverio, Salomone, Vallance, Abigail, Vimalchandran, Dale, Evans, Richard PT, Townend, Philip, McKay, Siobhan, Isaac, John, Satoi, Sohei, Coonar, Aman S, Marchbank, Adrian, Caruana, Edward J, Layton, Georgia R, Patel, Akshay, Brunelli, Alessandro, Ford, Samuel, Desai, Anant, Gronchi, Alessandro, Almond, Max, Tirotta, Fabio, Dumitra, Sinziana, Kolias, Angelos, Price, Stephen J, Fountain, Daniel M, Jenkinson, Michael D, Marcus, Hani J, Piper, Rory J, Lippa, Laura, Servadei, Franco, Esene, Ignatius, Freyschlag, Christian, Neville, Iuri, Rosseau, Gail, Schaller, Karl, Demetriades, Andreas K, Robertson, Faith, Alamri, Alex, Schache, Andrew G, Winter, Stuart C, Ho, Michael, Nankivell, Paul, Rey Biel, Juan, Batstone, Martin, Ganly, Ian, Wilkins, Alex, Singh, Jagdeep K, Thekinkattil, Dinesh, Leung, Elaine YL, Khan, Tabassum, Chiva, Luis, Sehouli, Jalid, Fagotti, Anna, Cohen, Paul, Gutelkin, Murat, Ghebre, Rahel, Konney, Thomas, Pareja, Rene, Bristow, Rob, Dowdy, Sean, Shylasree, TS, Ng, Joe, Fujiwara, Keiichi, Lamb, Benjamin, Narahari, Krishna, McNeill, Alan, Colquhoun, Alexandra, McGrath, John S, Bromage, Steve, Barod, Ravi, Kasivisvanathan, Veeru, Klatte, Tobias, Abbott, Tom EF, Abukhalaf, Sadi, Adamina, Michel, Ademuyiwa, Adesoji O, Agarwal, Arnav, Akkulak, Murat, Alameer, Ehab, Alderson, Derek, Alakaloko, Felix, Albertsmeier, Markus, Alser, Osaid, Alshaar, Muhammad, Alshryda, Sattar, Augestad, Knut Magne, Bankhead-Kendall, Brittany K, Barlow, Emma, Beard, David, Blanco-Colino, Ruth, Brar, Amanpreet, Breen, Kerry A, Bretherton, Chris, Buarque, Igor Lima, Burke, Joshua, Chaar, Mohammad, Chakrabortee, Sohini, Christensen, Peter, Cox, Daniel, Cukier, Moises, Cunha, Miguel F, Davidson, Giana H, Drake, Thomas M, Edwards, John G, Emile, Sameh, Farik, Shebani, Fitzgerald, J Edward, Garmanova, Tatiana, Grecinos, Gustavo, Gruendl, Magdalena, Halkias, Constantine, Harrison, Ewen M, Hisham, Intisar, Hutchinson, Peter J, Hwang, Shelley, Isik, Arda, Jonker, Pascal, Kaafarani, Haytham MA, Keller, Debby, Kruijff, Schelto, Litvin, Andrey, Loehrer, Andrew, Löffler, Markus W, Lorena, Maria Aguilera, Modolo, Maria Marta, Major, Piotr, Mashbari, Hassan N, Metallidis, Symeon, Mohan, Helen M, Moszkowicz, David, Ng-Kamstra, Joshua S, Maimbo, Mayaba, Negoi, Ionut, Niquen, Milagros, Olivos, Maricarmen, Oussama, Kacimi, Outani, Oumaima, Parreno-Sacdalanm, Marie Dione, Rivera, Carlos Jose Perez, Pinkney, Thomas D, van der Plas, Willemijn, Qureshi, Ahmad, Radenkovic, Dejan, Richards, Toby, Roslani, April C, Rutegård, Martin, Segura-Sampedro, Juan José, Santos, Irène, Sayyed, Raza, Schache, Andrew, Schnitzbauer, Andreas A, Seyi-Olajide, Justina O, Sharma, Neil, Shaw, Catherine A, Shu, Sebastian, Soreide, Kjetil, Spinelli, Antonino, Sund, Malin, Tsoulfas, Georgios, van Ramshorst, Gabrielle H, Vimalachandran, Dale, Warren, Oliver J, Wedderburn, Duane, Wright, Naomi, EuroSurg, Booth, Lesley, Runigamugabo, Emmy, Barker, Margaret, Barker, Neil, Cooke, Shirley, Doré, Suzanne, Horwood, Nigel, Tierney Weir, Carrie, Dajti, I, Allemand, C, Boccalatte, LA, Figari, M, Lamm, M, Larrañaga, J, Marchitelli, C, Noll, F, Odetto, D, Perrotta, M, Saadi, J, Zamora, L, Ballester, AM, Tapper, KE, Zeff, N, Valenzuela, JI, Alurralde, C, Anastasio, J, Apas Perez de Nucci, A, Caram, EL, Eskinazi, D, Mendoza, JP, Usandivaras, M, Badra, R, Esteban, A, García, JS, García, PM, Gerchunoff, JI, Lucchini, SM, NIgra, MA, Vargas, L, Hovhannisyan, T, Stepanyan, A, Vasey, CE, Watson, EGR, Ip, C, Kealey, J, Lim, CSH, Sengupta, S, Ward, S, Wong, E, Gould, T, Gourlay, R, Griffiths, B, Gananadha, S, McLaren, M, Cecire, J, Joshi, N, Salindera, S, Sutherland, A, Ahn, JH, Charlton, G, Chen, S, Gauri, N, Hayhurst, R, Jang, S, Jia, F, Mulligan, C, Yang, W, Ye, G, Zhang, H, Ballal, M, Gibson, D, Hayne, D, McMillan, H, Moss, J, Pugliese, MJ, Richards, T, Seow, YTN, Thian, A, Viswambaram, P, Vo, UG, Bennetts, J, Bright, T, Brooke-Smith, M, Fong, R, Gricks, B, Huang, L, Lam, YH, Nathan, A, Ong, BS, Ooi, E, Szpytma, M, Watson, D, Bagraith, K, Caird, S, Chan, E, Dawson, C, Ho, D, Hui, N, Izwan, S, Jeyarajan, E, Jordan, S, Liang, R, Lim, A, Nolan, GJ, Oar, A, Parker, D, Puhalla, H, Quennell, A, Rutherford, L, Sommerville, C, Townend, P, Von Papen, M, Wullschleger, M, Dawson, AC, Drane, A, Blatt, A, Cope, D, Egoroff, N, Fenton, M, Gani, J, Lott, N, Pockney, P, Shugg, N, Elliott, M, Phung, D, Phan, D, Townend, D, Bong, C, Gundara, J, Frankel, A, Bowman, S, Guerra, GR, Gerns, N, McGeorge, S, Riddell, A, Roberts, M, Rukin, N, Bolt, J, Buddingh, K, Dudi-Venkata, NN, Jog, S, Kroon, HM, Sammour, T, Smith, R, Stranz, C, Batstone, M, Lah, K, McGahan, W, Mitchell, D, Morton, A, Pearce, A, Sheahan, G, Swinson, B, Waldron, A, Walker, P, Alam, N, Banting, S, Chong, L, Choong, P, Clatworthy, S, Foley, D, Fox, A, Hii, MW, Knowles, B, Mack, J, Read, M, Rowcroft, A, Wright, G, Lun, EWY, Lanner, M, Burtscher, J, Trivik-Barrientos, F, Königsrainer, I, Bauer, M, Freyschlag, C, Kafka, M, Messner, F, Öfner, D, Tsibulak, I, Holawe, S, Zimmermann, M, Emmanuel, K, Grechenig, M, Gruber, R, Harald, M, Öhlberger, L, Presl, J, Wimmer, A, Namazov, I, Samadov, E, Barker, D, Boyce, R, Corbin, S, Doyle, A, Eastmond, A, Gill, R, Haynes, A, Millar, S, O'Shea, M, Padmore, G, Paquette, N, Phillips, E, St. John, S, Walkes, K, Abeloos, J, De Backer, T, De Ceulaer, J, Dick, C, Diez-Fraile, A, Lamoral, P, Spaas, C, Ceelen, W, Pattyn, P, Van de putte, D, Van Nieuwenhove, Y, Van Ramshorst, G, Willaert, W, Bazzett-Matabele, L, Chiyapo, SP, Ramogola-Masire, D, Ramontshonyana, G, Seiphetlheng, A, Vuylsteke, P, Abdallah, EA, Aguiar Júnior, S, Baiocchi, G, Carvalho, GB, Coimbra, FJF, Kowalski, LP, Makdissi, F, Marques, N, Marques, T, Soares Dos Santos, S, Tirapelli Gonçalves, B, Vartanian, JG, Dos Reis, R, Camara, P, De Lima, RK, Della Giustina, E, Hoffmann, PV, Gatti, A, Nardi, C, Oliva, R, Nacif, L, Carvalho Ferro, C, Gomes Mendonça Ataíde, G, Lima Buarque, I, Lira dos Santos Leite, A, Pol-Fachin, L, Santos Bezerra, T, Maylson Ramos da Silva, A, Windson de Araújo Silvestre, D, Vieira Barros, A, Campbell, L, De Cicco, R, Cecconello, I, Gregorio, P, Pontual Lima, L, Ribeiro Junior, U, Takeda, FR, Terra, RM, Faccini Teixeira, M, Kulcsar, MAV, Matos, LL, Nunes, KS, Laporte, G, Salem, M, Barakat Awada, J, Ijichi, TR, Kim, NJ, Marreiro, A, Muller, B, Nunes, R, Bodanese, B, Eidt, ER, Isoton, JC, Lemos Vieira da Cunha, M, Regina de Sampaio, L, Vendrame, C, Zeni, M, Zortéa, JA, Zortéa, MR, Sokolov, M, Kidane, B, Srinathan, S, Munro, A, Helyer, L, McKeen, D, Boutros, M, 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K, Naredla, P, Robertson, S, Sait, M, Sarma, DR, Shanbhag, S, Shortland, T, Simmonds, S, Skillman, J, Tewari, N, Walton, G, Akhtar, MA, Brunt, A, McIntyre, J, Milne, K, Rashid, MM, Sgrò, A, Stewart, KE, Turnbull, A, Abou-Foul, AK, Gossedge, G, O'Donnell, S, Oldfield, F, Thomson, S, Aguilar Gonzalez, M, Talukder, S, Boyle, C, Fernando, D, Gallagher, K, Laird, A, Tham, D, Bath, M, Basnyat, P, Davis, H, Montauban, P, Shrestha, A, Agarwal, K, Arif, T, Magee, C, Nambirajan, T, Powell, S, Vinayagam, R, Flindall, I, Hanson, A, Mahendran, V, Green, S, Lim, M, MacDonald, L, Miu, V, Onos, L, Sheridan, K, Young, R, Alam, F, Griffiths, O, Houlden, C, Kolli, VS, Lala, AK, Leeson, S, Peevor, R, Seymour, Z, Consorti, E, Gonzalez, R, Grolman, R, Kwan-Feinberg, R, Liu, T, Merzlikin, O, Brown, A, Cooper, Z, Hirji, S, Jolissaint, J, Mahvi, D, Okafor, B, Raut, CP, Roxo, V, Salim, A, Bessen, S, Chen, L, Dagrosa, L, Fay, K, Fleischer, C, Hasson, R, Henderson, E, Leech, M, Loehrer, A, Markey, C, Paydarfar, 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Ssentongo, A, Ssentongo, P, Bhama, A, Colling, K, Najarian, M, Azam, M, Choudhry, A, Marx, W, Abedin, Y, Arzumanov, G, Chokshi, R, Gabrilovich, S, Glass, N, Kalyoussef, E, Parvin-Nejad, FP, Roden, D, Stein, J, Suarez-Ligon, A, Tsui, G, Zhao, K, Fleming, J, Fuson, A, Gigliotti, J, Ovaitt, A, Ying, Y, Abel, MK, Andaya, V, Bigay, K, Boeck, MA, Chern, H, Corvera, C, El-Sayed, I, Glencer, A, Ha, P, Hamilton, BCS, Heaton, C, Hirose, K, Jablons, DM, Kirkwood, KS, Kornblith, LZ, Kratz, JR, Lee, RH, Miller, PN, Nakakura, EK, Nunez-Garcia, B, O'Donnell, RJ, Ozgediz, D, Park, P, Robinson, B, Sarin, A, Sheu, B, Varma, MG, Wai, KC, Wustrack, R, Xu, MJ, Zimel, M, Beswick, D, Goddard, J, Manor, J, Song, J, Cioci, A, Pavlis, W, Rakoczy, K, Ruiz, G, Saberi, R, Fullmer, T, Gaskill, C, Gross, N, Kiong, K, Roland, CL, Zafar, SN, Abdallah, M, Abouassi, A, Aigbivbalu, E, Eid, J, George, B, Kulkarni, G, Marwan, H, Mehdi, M, San Andrés, M, Sundaresan, J, Aoun, SG, Ban, VS, Batjer, HH, Bosler, K, Caruso, J, Sumer, B, Abbott, D, Acher, A, Aiken, T, Barrett, J, Foley, E, Schwartz, PB, Hawkins, AT, Maiga, A, Ruzgar, NM, Sion, M, Ullrich, S, Laufer, J, Scasso, S, Al-Naggar, H, Al-Shehari, M, Almassaudi, A, Alsayadi, M, Alsayadi, R, Nahshal, M, Shream, S, AL-Ameri, S, and Aldawbali, M
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- 2021
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39. Management of Rare Uterine Malignant Tumors
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Amant, Frederic, Hensley, Martee, Pautier, Patricia, Friedlander, Michael, Sagae, Satoru, Fujiwara, Keiichi, Berton Rigaud, Dominique, Lorusso, Domenica, Ray-Coquard, Isabelle, and Mirza, Mansoor R., editor
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- 2020
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40. Chemotherapy with or without avelumab followed by avelumab maintenance versus chemotherapy alone in patients with previously untreated epithelial ovarian cancer (JAVELIN Ovarian 100): an open-label, randomised, phase 3 trial
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Monk, Bradley J, Colombo, Nicoletta, Oza, Amit M, Fujiwara, Keiichi, Birrer, Michael J, Randall, Leslie, Poddubskaya, Elena V, Scambia, Giovanni, Shparyk, Yaroslav V, Lim, Myong Cheol, Bhoola, Snehalkumar M, Sohn, Joohyuk, Yonemori, Kan, Stewart, Ross A, Zhang, Xiaoxi, Perkins Smith, Julia, Linn, Carlos, and Ledermann, Jonathan A
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- 2021
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41. Avelumab alone or in combination with chemotherapy versus chemotherapy alone in platinum-resistant or platinum-refractory ovarian cancer (JAVELIN Ovarian 200): an open-label, three-arm, randomised, phase 3 study
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Pujade-Lauraine, Eric, Fujiwara, Keiichi, Ledermann, Jonathan A, Oza, Amit M, Kristeleit, Rebecca, Ray-Coquard, Isabelle-Laure, Richardson, Gary E, Sessa, Cristiana, Yonemori, Kan, Banerjee, Susana, Leary, Alexandra, Tinker, Anna V, Jung, Kyung Hae, Madry, Radoslaw, Park, Sang-Yoon, Anderson, Charles K, Zohren, Fabian, Stewart, Ross A, Wei, Caimiao, Dychter, Samuel S, and Monk, Bradley J
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- 2021
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42. Immunogenomic landscape of gynecologic carcinosarcoma
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Gotoh, Osamu, Kiyotani, Kazuma, Chiba, Tomohiro, Sugiyama, Yuko, Takazawa, Yutaka, Nemoto, Kensaku, Kato, Kazuyoshi, Tanaka, Norio, Nomura, Hidetaka, Hasegawa, Kosei, Fujiwara, Keiichi, Takamatsu, Shiro, Matsumura, Noriomi, Noda, Tetsuo, and Mori, Seiichi
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- 2021
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43. Bevacizumab and paclitaxel-carboplatin chemotherapy and secondary cytoreduction in recurrent, platinum-sensitive ovarian cancer (NRG Oncology/Gynecologic Oncology Group study GOG-0213): a multicentre, open-label, randomised, phase 3 trial.
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Coleman, Robert L, Brady, Mark F, Herzog, Thomas J, Sabbatini, Paul, Armstrong, Deborah K, Walker, Joan L, Kim, Byoung-Gie, Fujiwara, Keiichi, Tewari, Krishnansu S, O'Malley, David M, Davidson, Susan A, Rubin, Stephen C, DiSilvestro, Paul, Basen-Engquist, Karen, Huang, Helen, Chan, John K, Spirtos, Nick M, Ashfaq, Raheela, and Mannel, Robert S
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Humans ,Neoplasms ,Glandular and Epithelial ,Peritoneal Neoplasms ,Ovarian Neoplasms ,Fallopian Tube Neoplasms ,Neoplasm Recurrence ,Local ,Paclitaxel ,Carboplatin ,Antineoplastic Combined Chemotherapy Protocols ,Disease-Free Survival ,Survival Rate ,Adult ,Aged ,Aged ,80 and over ,Middle Aged ,Female ,Young Adult ,Cytoreduction Surgical Procedures ,Bevacizumab ,Carcinoma ,Ovarian Epithelial ,Neoplasms ,Glandular and Epithelial ,Neoplasm Recurrence ,Local ,and over ,Carcinoma ,Ovarian Epithelial ,Oncology & Carcinogenesis ,Oncology and Carcinogenesis - Abstract
BackgroundPlatinum-based chemotherapy doublets are a standard of care for women with ovarian cancer recurring 6 months after completion of initial therapy. In this study, we aimed to explore the roles of secondary surgical cytoreduction and bevacizumab in this population, and report the results of the bevacizumab component here.MethodsThe multicentre, open-label, randomised phase 3 GOG-0213 trial was done in 67 predominantly academic centres in the USA (65 centres), Japan (one centre), and South Korea (one centre). Eligible patients were adult women (aged ≥18 years) with recurrent measurable or evaluable epithelial ovarian, primary peritoneal, or fallopian tube cancer, and a clinical complete response to primary platinum-based chemotherapy, who had been disease-free for at least 6 months following last infused cycle of platinum. Patients were randomly assigned (1:1) to standard chemotherapy (six 3-weekly cycles of paclitaxel [175 mg/m2 of body surface area] and carboplatin [area under the curve 5]) or the same chemotherapy regimen plus bevacizumab (15 mg/kg of bodyweight) every 3 weeks and continued as maintenance every 3 weeks until disease progression or unacceptable toxicity. Individuals who participated in both the bevacizumab objective and surgical objective (which is ongoing) were randomly assigned (1:1:1:1) to receive either of these two chemotherapy regimens with or without prior secondary cytoreductive surgery. Randomisation for the bevacizumab objective was stratified by treatment-free interval and participation in the surgical objective. The primary endpoint was overall survival, analysed by intention to treat. This study is registered with ClinicalTrials.gov, number NCT00565851.FindingsBetween Dec 10, 2007, and Aug 26, 2011, 674 women were enrolled and randomly assigned to standard chemotherapy (n=337) or chemotherapy plus bevacizumab (n=377). Median follow-up at the end of the trial on Nov 5, 2014, was 49·6 months in each treatment group (IQR 41·5-62·2 for chemotherapy plus bevacizumab; IQR 40·8-59·3 for chemotherapy), at which point 415 patients had died (214 in the chemotherapy group and 201 in the chemotherapy plus bevacizumab group). Based on pretreatment stratification data, median overall survival in the chemotherapy plus bevacizumab group was 42·2 months (95% CI 37·7-46·2) versus 37·3 months (32·6-39·7) in the chemotherapy group (hazard ratio [HR] 0·829; 95% CI 0·683-1·005; p=0·056). We identified incorrect treatment-free interval stratification data for 45 (7%) patients (equally balanced between treatment groups); a sensitivity analysis of overall survival based on the audited treatment-free interval stratification data gave an adjusted HR of 0·823 (95% CI 0·680-0·996; p=0·0447). In the safety population (all patients who initiated treatment), 317 (96%) of 325 patients in the chemotherapy plus bevacizumab group had at least one grade 3 or worse adverse event compared with 282 (86%) of 332 in the chemotherapy group; the most frequently reported of these in the chemotherapy plus bevacizumab group compared with the chemotherapy group were hypertension (39 [12%] vs two [1%]), fatigue (27 [8%] vs eight [2%]), and proteinuria (27 [8%] vs none). Two (1%) treatment-related deaths occurred in the chemotherapy group (infection [n=1] and myelodysplastic syndrome [n=1]) compared with nine (3%) in the chemotherapy plus bevacizumab group (infection [n=1], febrile neutropenia [n=1], myelodysplastic syndrome [n=1], secondary malignancy [n=1]; deaths not classified with CTCAE terms: disease progression [n=3], sudden death [n=1], and not specified [n=1]).InterpretationThe addition of bevacizumab to standard chemotherapy, followed by maintenance therapy until progression, improved the median overall survival in patients with platinum-sensitive recurrent ovarian cancer. Although the intention-to-treat analysis for overall survival was not significant, our sensitivity analysis based on corrected treatment-free interval stratification indicates that this strategy might be an important addition to the therapeutic armamentarium in these patients.FundingNational Cancer Institute and Genentech.
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- 2017
44. Analysis of autoimmune hepatitis with acute presentation in the early stage of illness.
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Fujiwara, Keiichi, Fukuda, Yoshihiro, Sanada, Masahiko, Koizumi, Shuko, Seza, Katsushi, Saito, Masaya, Yokosuka, Osamu, and Kato, Naoya
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Background and Aim Methods Result Conclusions There is no gold standard for making the diagnosis of autoimmune hepatitis (AIH), and the diagnosis of acute onset AIH (A‐AIH) is most challenging. A‐AIH sometimes develops into acute liver failure with poor prognosis if the diagnosis is delayed. Therefore, it is most important for the better prognosis to diagnose non‐severe A‐AIH early and treat appropriately. However, features in the early stage of A‐AIH are unclear. We examined initial characteristics of non‐severe A‐AIH in detail and tried to find novel clinical features for the early diagnosis.Clinical, biochemical, immunological, radiological, and histological features of 71 patients (54 women, mean age 57.9 ± 14.3 years) with non‐severe A‐AIH admitted to community hospitals between 2001 and 2022 were analyzed retrospectively.Forty‐six had no symptom on onset and liver injuries were discovered by regular medical checkups. The mean duration from onset to consultation was 25.0 ± 29.3 days. Liver histology showed acute hepatitis in 59% and chronic hepatitis in 41%. Patients with symptoms revealed more male sex (
P = 0.039), higher alanine aminotransferase (P < 0.001), higher total bilirubin (P < 0.001), and higher rate of histological acute hepatitis (P = 0.0013) than those without symptoms significantly. Male sex, presence of symptoms on onset, occurrence of jaundice in the course, and histological acute hepatitis were correlated.Sixty‐five percent of non‐severe A‐AIH patients were asymptomatic on onset, suggesting that A‐AIH would develop insidiously and present a longer clinical course than that reported. Male patients more often revealed true acute hepatitis clinically, biochemically, and histologically than female ones. [ABSTRACT FROM AUTHOR]- Published
- 2024
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45. Impacts of probiotics on the efficacies of immune checkpoint inhibitors with or without chemotherapy for patients with advanced non‐small‐cell lung cancer.
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Morita, Ayako, Ichihara, Eiki, Inoue, Koji, Fujiwara, Keiichi, Yokoyama, Toshihide, Harada, Daijiro, Ando, Chihiro, Kano, Hirohisa, Oda, Naohiro, Tamura, Tomoki, Ochi, Nobuaki, Kawai, Haruyuki, Inoue, Masaaki, Hara, Naofumi, Fujimoto, Nobukazu, Ichikawa, Hirohisa, Oze, Isao, Hotta, Katsuyuki, Maeda, Yoshinobu, and Kiura, Katsuyuki
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NON-small-cell lung carcinoma ,IMMUNE checkpoint inhibitors ,EPIDERMAL growth factor receptors ,PROBIOTICS ,IPILIMUMAB ,PEMETREXED - Abstract
The relationships between the therapeutic effects of immune checkpoint inhibitors (ICIs) and the intestinal flora have attracted increasing attention. However, the effects of oral probiotics on the efficacies of ICIs used to treat non‐small‐cell lung cancer (NSCLC) remain unclear. We investigated the effects of probiotics on the efficacies of ICIs in patients treated with and without chemotherapy. We investigated patients with advanced NSCLC on ICI monotherapy or combination ICI and chemotherapy using the Okayama Lung Cancer Study Group Immunotherapy Database (OLCSG‐ID) and the Okayama Lung Cancer Study Group Immunochemotherapy Database (OLCSG‐ICD). In total, 927 patients (482 on ICI monotherapy, 445 on an ICI + chemotherapy) were enrolled. Most were male, of good performance status, smokers, and without epidermal growth factor receptor (EGFR)/anaplastic lymphoma kinase (ALK) mutations. Probiotics were administered to 19% of patients on ICI monotherapies and 17% of those on ICIs + chemotherapy. Of the former patients, progression‐free survival (PFS) and overall survival (OS) were significantly better in the probiotics group (PFS 7.9 vs. 2.9 months, hazard ratio [HR] 0.54, p <.001; OS not attained vs. 13.1 months, HR 0.45, p <.001). Among patients receiving ICI and chemotherapy, there were no significant differences in PFS between those on probiotics and not but OS was significantly better in the probiotics group (PFS 8.8 vs. 8.6 months, HR 0.89, p =.43; OS not attained vs. 22.6 months, HR 0.61, p =.03). Patients on probiotics experienced better outcomes following ICI treatment. [ABSTRACT FROM AUTHOR]
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- 2024
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46. Survival With Cemiplimab in Recurrent Cervical Cancer
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Tewari, Krishnansu S., Monk, Bradley J., Vergote, Ignace, Miller, Austin, de Melo, Andreia C., Kim, Hee-Seung, Kim, Yong Man, Lisyanskaya, Alla, Samouëlian, Vanessa, Lorusso, Domenica, Damian, Fernanda, Chang, Chih-Long, Gotovkin, Evgeniy A., Takahashi, Shunji, Ramone, Daniella, Pikiel, Joanna, Maćkowiak-Matejczyk, Beata, Alía, Eva M. Guerra, Colombo, Nicoletta, Makarova, Yulia, Rischin, Danny, Lheureux, Stephanie, Hasegawa, Kosei, Fujiwara, Keiichi, Li, Jingjin, Jamil, Shaheda, Jankovic, Vladimir, Chen, Chieh-I, Seebach, Frank, Weinreich, David M., Yancopoulos, George D., Lowy, Israel, Mathias, Melissa, Fury, Matthew G., and Oaknin, Ana
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- 2022
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47. Lenvatinib Plus Pembrolizumab for Advanced Endometrial Cancer
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Makker, Vicky, Colombo, Nicoletta, Herráez, Antonio Casado, Santin, Alessandro D., Colomba, Emeline, Miller, David S., Fujiwara, Keiichi, Pignata, Sandro, Baron-Hay, Sally, Ray-Coquard, Isabelle, Shapira-Frommer, Ronnie, Ushijima, Kimio, Sakata, Jun, Yonemori, Kan, Kim, Yong Man, Guerra, Eva M., Sanli, Ulus A., McCormack, Mary M., Smith, Alan D., Keefe, Stephen, Bird, Steven, Dutta, Lea, Orlowski, Robert J., and Lorusso, Domenica
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- 2022
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48. Prediction of response to promising first-line chemotherapy in ovarian cancer patients with residual peritoneal tumors: Practical biomarkers and robust multiplex models
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Kawabata-Iwakawa, Reika, primary, Iwasa, Norihiro, additional, Satoh, Kenichi, additional, Colinge, Jacques, additional, Shimada, Muneaki, additional, Takeuchi, Satoshi, additional, Fujiwara, Hiroyuki, additional, Eguchi, Hidetaka, additional, Oishi, Tetsuro, additional, Sugiyama, Toru, additional, Suzuki, Mitsuaki, additional, Hasegawa, Kosei, additional, Fujiwara, Keiichi, additional, and Nishiyama, Masahiko, additional
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- 2024
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49. Autopsy case of meningoencephalitis induced by nivolumab and ipilimumab in a patient being treated for non-small cell lung cancer
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Shiraha, Keisuke, primary, Watanabe, Hiromi, additional, Fujiwara, Keiichi, additional, Goda, Mayu, additional, Inoue, Tomoyoshi, additional, Fujiwara, Miho, additional, Matsuoka, Suzuka, additional, Takigawa, Yuki, additional, Mitsumune, Sho, additional, Kudo, Kenichiro, additional, Sato, Akiko, additional, Sato, Ken, additional, Shinno, Yoko, additional, and Shibayama, Takuo, additional
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- 2024
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50. Analysis of East Asia Subgroup in Study 309/KEYNOTE-775: Lenvatinib plus pembrolizumab versus treatment of physician’s choice chemotherapy in patients with previously treated advanced or recurrent endometrial cancer
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Yonemori, Kan, primary, Fujiwara, Keiichi, additional, Hasegawa, Kosei, additional, Yunokawa, Mayu, additional, Ushijima, Kimio, additional, Suzuki, Shiro, additional, Shikama, Ayumi, additional, Minobe, Shinichiro, additional, Usami, Tomoka, additional, Kim, Jae-Weon, additional, Kim, Byoung-Gie, additional, Wang, Peng-Hui, additional, Chang, Ting-Chang, additional, Yamamoto, Keiko, additional, Han, Shirong, additional, McKenzie, Jodi, additional, Orlowski, Robert J., additional, Miura, Takuma, additional, Makker, Vicky, additional, and Man Kim, Yong, additional
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- 2024
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