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170 results on '"Fujita, Masahide"'

10. Reduction of Neuropathic and Inflammatory Pain through Inhibition of the Tetrahydrobiopterin Pathway

Author

Latremoliere, Alban, Latini, Alexandra, Andrews, Nick, Cronin, Shane J., Fujita, Masahide, Gorska, Katarzyna, Hovius, Ruud, Romero, Carla, Chuaiphichai, Surawee, Painter, Michio, Miracca, Giulia, Babaniyi, Olusegun, Remor, Aline Pertile, Duong, Kelly, Riva, Priscilla, Barrett, Lee B., Ferreirós, Nerea, Naylor, Alasdair, Penninger, Josef M., Tegeder, Irmgard, Zhong, Jian, Blagg, Julian, Channon, Keith M., Johnsson, Kai, Costigan, Michael, and Woolf, Clifford J.

Published
2015
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18. Transnasal transplantation of human induced pluripotent stem cell‐derived microglia to the brain of immunocompetent mice

Author

Parajuli, Bijay, primary, Saito, Hiroki, additional, Shinozaki, Youichi, additional, Shigetomi, Eiji, additional, Miwa, Hiroto, additional, Yoneda, Sosuke, additional, Tanimura, Miki, additional, Omachi, Shigeki, additional, Asaki, Toshiyuki, additional, Takahashi, Koji, additional, Fujita, Masahide, additional, Nakashima, Kinichi, additional, and Koizumi, Schuichi, additional

Published
2021
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23. Allopregnanolone suppresses mechanical allodynia and internalization of neurokinin-1 receptors at the spinal dorsal horn in a rat postoperative pain model

Author

Fujita, Masahide, Fukuda, Taeko, Sato, Yasuhiro, and Takasusuki, Toshifumi

Abstract

Background To identify a new strategy for postoperative pain management, we investigated the analgesic effects of allopregnanolone (Allo) in an incisional pain model, and also assessed its effects on the activities of the primary afferent fibers at the dorsal horn. Methods In experiment 1, 45 rats were assigned to Control, Allo small-dose (0.16 mg/kg), and Allo large-dose (1.6 mg/kg) groups (n = 15 in each). The weight bearing and mechanical withdrawal thresholds of the hind limb were measured before and at 2, 24, 48, and 168 h after Brennan's surgery. In experiment 2, 16 rats were assigned to Control and Allo (0.16 mg/kg) groups (n = 8 in each). The degree of spontaneous pain was measured using the grimace scale after the surgery. Activities of the primary afferent fibers in the spinal cord (L6) were evaluated using immunohistochemical staining. Results In experiment 1, the withdrawal threshold of the Allo small-dose group was significantly higher than that of the Control group at 2 h after surgery. Intergroup differences in weight bearing were not significant. In experiment 2, intergroup differences in the grimace scale scores were not significant. Substance P release in the Allo (0.16 mg/kg) group was significantly lower than that in the Control group. Conclusions Systemic administration of Allo inhibited mechanical allodynia and activities of the primary afferent fibers at the dorsal horn in a rat postoperative pain model. Allo was proposed as a candidate for postoperative pain management.

Published
2018

26. Sepiapterin reductase inhibition selectively reduces inflammatory joint pain and increases urinary sepiapterin

Author

Fujita, Masahide, da Luz Scheffer, Débora, Lenfers Turnes, Bruna, Cronin, Shane J. F., Latrémolière, Alban, Costigan, Michael, Woolf, Clifford J., Latini, Alexandra, and Andrews, Nick A.

Subjects
Adult, Male, Pain Threshold, Hot Temperature, Hyperesthesia, education, Arthritis, Experimental, Biopterin, Article, Hindlimb, Pterins, Cold Temperature, Sulfasalazine, Alcohol Oxidoreductases, Mice, Antirheumatic Agents, Animals, Humans, Female, Joints, Biomarkers, Chromatography, High Pressure Liquid
Abstract

To evaluate the antiinflammatory and analgesic effects of sepiapterin reductase (SPR) inhibition in a mouse model of inflammatory joint disease, and to determine whether urinary sepiapterin levels, as measured in mice and healthy human volunteers, could be useful as a noninvasive, translational biomarker of SPR inhibition/target engagement.The collagen antibody-induced arthritis (CAIA) model was used to induce joint inflammation in mice. The effects of pharmacologic inhibition of SPR on thresholds of heat-, cold-, and mechanical-evoked pain sensitivity and on signs of inflammation were tested in mice with CAIA. In addition, mice and healthy human volunteers were treated with SPR inhibitors, and changes in urinary sepiapterin levels were analyzed by high-performance liquid chromatography.CAIA in mice was characterized by 2 phases: in the acute inflammation (early) phase, joint inflammation and heat-, mechanical-, and cold-induced pain hypersensitivity were present, while in the postinflammation (late) phase, no joint inflammation was observed but heat- and mechanical-induced hypersensitivity, but not cold hypersensitivity, were present. Inhibition of SPR in mice with CAIA significantly attenuated the heat-induced hyperalgesia in both phases, and the mechanical allodynia in the late phase. Signs of inflammation were unaffected by SPR inhibition. Urinary tetrahydrobiopterin levels, as a marker of inflammatory pain, were increased during inflammation in mice with CAIA (2-fold increase over controls; P0.05) and significantly reduced by SPR inhibition (P0.05 versus vehicle-treated mice). Increased urinary sepiapterin levels in the presence of SPR inhibition in both mice and healthy human volunteers were associated with high sensitivity (70-85%) and high specificity (82-88%) for the prediction of SPR inhibition/target engagement.SPR inhibition reduces the pain associated with joint inflammation, thus showing its potential utility as an analgesic strategy for inflammatory joint pain. In addition, SPR inhibition increases urinary sepiapterin levels, indicating the potential of this measurement as a noninvasive biomarker of target engagement of SPR inhibitors, such as sulfasalazine, a disease-modifying antirheumatic drug that is currently used as a first-line treatment for rheumatoid arthritis.

Published
2019

28. Sepiapterin Reductase Inhibition Leading to Selective Reduction of Inflammatory Joint Pain in Mice and Increased Urinary Sepiapterin Levels in Humans and Mice

Author

Fujita, Masahide, primary, Scheffer, Débora da Luz, additional, Turnes, Bruna Lenfers, additional, Cronin, Shane J. F., additional, Latrémolière, Alban, additional, Costigan, Michael, additional, Woolf, Clifford J., additional, Latini, Alexandra, additional, and Andrews, Nick A., additional

Published
2019
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31. Contribution of synovial macrophages to rat advanced osteoarthritis pain resistant to cyclooxygenase inhibitors

Author

Sakurai, Yusuke, primary, Fujita, Masahide, additional, Kawasaki, Shiori, additional, Sanaki, Takao, additional, Yoshioka, Takeshi, additional, Higashino, Kenichi, additional, Tofukuji, Soichi, additional, Yoneda, Sosuke, additional, Takahashi, Tatsuya, additional, Koda, Ken, additional, Asaki, Toshiyuki, additional, Hasegawa, Minoru, additional, and Morioka, Yasuhide, additional

Published
2018
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32. The MAC-BIS50-tetanus of desflurane decreases by aging

Author

Fujita, Masahide

Abstract

Background: Intraoperative awakening is one of the complications which should be avoided. The minimum alveolar concentration of volatile anesthetics is an important factor in the suppression of biological response to nociceptive stimulation. A bispectral index (BIS) monitor is valuable for the maintenance of appropriate sedation; we have previously reported the minimum alveolar concentration (MAC) of desflurane at which the BIS index does not exceed 50 during nociceptive stimulation (MAC-BIS50-tetanus) was 4.27 % (95%CI: 4.15 u2013 4.39 %) in the adult patients (aged from 31 to 65 years). In this study, we investigated MAC-BIS50-tetanus in the elder patients (aged over 65 years).Method: This study was approved by the ethics committee at Tsukuba University Hospital. The patients undergoing scheduled operation were recruited to this study, and written informed consent was obtained from all of them. The patients who had psychological disease and received sedatives were excluded. Anesthesia was induced with sevoflurane and 60% of nitrous oxide in 40% of oxygen and air. After the administration of rocuronium (0.6 mg/kg), a supra-glottic device (LMA or igel) was introduced. Then, administration of nitrous oxide and sevoflurane was then terminated, and we confirmed that the pre-determined end-tidal concentration of desflurane maintained for 10 minutes. The neuromuscular monitoring was used as a nociceptive stimulator; the altitude of the stimulation was 80 mA for 10 seconds, which is reported to be equal to skin incisional pain in the ulnar nerve. The BIS index was recorded every 10 seconds for 1 minute from beginning 1 minute after the stimulation. We defined the average of 6 BIS values as the BIS index for each patient. The MAC-BIS50-tetanus was determined using Dixonu2019s up-and-down method.Result: A total of 19 elder patients were registered in this study. The MAC-BIS50-tetanus of desflurane was 3.53% (95%CI: 3.38u2013 3.69 %) in adult patients.Conclusion: The MAC-BIS50-tetunus of desflurane was 3.53% (95%CI: 3.38 u2013 3.69 %) in the elder patients. It was significantly lower than that of middle aged patients group. In elder patients, when the end-tidal concentration of desflurane is 3.53 %, the BIS index is suggested to exceed 50 in half of the patients during nociceptive stimulation.

Published
2017

35. Sepiapterin Reductase Inhibition Leading to Selective Reduction of Inflammatory Joint Pain in Mice and Increased Urinary Sepiapterin Levels in Humans and Mice.

Author

Fujita, Masahide, Scheffer, Débora da Luz, Turnes, Bruna Lenfers, Cronin, Shane J. F., Latrémolière, Alban, Costigan, Michael, Woolf, Clifford J., Latini, Alexandra, and Andrews, Nick A.

Subjects
*ANIMAL experimentation, *BIOMARKERS, *COENZYMES, *COLD (Temperature), *COLLAGEN, *ENZYME inhibitors, *HEAT, *HIGH performance liquid chromatography, *HYPERALGESIA, *INFLAMMATORY mediators, *MICE, *OXIDOREDUCTASES, *RHEUMATOID arthritis, *PAIN management, *PAIN threshold, *CHEMICAL inhibitors, *PHARMACODYNAMICS
Abstract

Objective: To evaluate the antiinflammatory and analgesic effects of sepiapterin reductase (SPR) inhibition in a mouse model of inflammatory joint disease, and to determine whether urinary sepiapterin levels, as measured in mice and healthy human volunteers, could be useful as a noninvasive, translational biomarker of SPR inhibition/target engagement. Methods: The collagen antibody–induced arthritis (CAIA) model was used to induce joint inflammation in mice. The effects of pharmacologic inhibition of SPR on thresholds of heat‐, cold‐, and mechanical‐evoked pain sensitivity and on signs of inflammation were tested in mice with CAIA. In addition, mice and healthy human volunteers were treated with SPR inhibitors, and changes in urinary sepiapterin levels were analyzed by high‐performance liquid chromatography. Results: CAIA in mice was characterized by 2 phases: in the acute inflammation (early) phase, joint inflammation and heat‐, mechanical‐, and cold‐induced pain hypersensitivity were present, while in the postinflammation (late) phase, no joint inflammation was observed but heat‐ and mechanical‐induced hypersensitivity, but not cold hypersensitivity, were present. Inhibition of SPR in mice with CAIA significantly attenuated the heat‐induced hyperalgesia in both phases, and the mechanical allodynia in the late phase. Signs of inflammation were unaffected by SPR inhibition. Urinary tetrahydrobiopterin levels, as a marker of inflammatory pain, were increased during inflammation in mice with CAIA (2‐fold increase over controls; P < 0.05) and significantly reduced by SPR inhibition (P < 0.05 versus vehicle‐treated mice). Increased urinary sepiapterin levels in the presence of SPR inhibition in both mice and healthy human volunteers were associated with high sensitivity (70–85%) and high specificity (82–88%) for the prediction of SPR inhibition/target engagement. Conclusion: SPR inhibition reduces the pain associated with joint inflammation, thus showing its potential utility as an analgesic strategy for inflammatory joint pain. In addition, SPR inhibition increases urinary sepiapterin levels, indicating the potential of this measurement as a noninvasive biomarker of target engagement of SPR inhibitors, such as sulfasalazine, a disease‐modifying antirheumatic drug that is currently used as a first‐line treatment for rheumatoid arthritis. [ABSTRACT FROM AUTHOR]

Published
2020
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37. Abstracts of selected papers presented at the 28th Annual Meeting of the Japanese Society of Gastroenterology Kanazawa, Japan, October 1–3, 1986

Author

Ogura, Yoshifumi, Yamagiwa, Hiroshi, Tsuzuki, Toshiharu, Ogata, Yoshiro, Konishi, Ichiro, Nagakawa, Takukazu, Miyazaki, Itsuo, Todoroki, Takeshi, Iwasaki, Yoji, Tanaka, Junichi, Koyama, Kenji, Nakamura, Hiroshi, Nagamori, Seishi, Homma, Sadamu, Kameda, Haruo, Karasawa, E., Saotome, N., Sugiura, N., Miki, M., Kuniyasu, Y., Suyama, Masafumi, Ariyama, Joe, Koga, Michiaki, Yano, Michitami, Tanaka, N., Watanabe, Toshiaki, Ichida, Fumihiro, Yamada, Gotaro, Gibo, Yukio, Saito, Shinobu, Hisamitsu, Toju, Tameda, Yukihiko, Kikkawa, N., Yagyuu, T., Kikkawa, Nobuteru, Sakata, Yuh, Munakata, Akihiro, Fujita, Masahide, Taguchi, Tetsuo, Takahashi, Yutaka, Mai, Masayoshi, Yamaguchi, Toshiharu, Takahashi, Toshio, Noguchi, T., Hamano, K., Eguchi, Hideo, Sugahara, Katsuhiko, Kimura, Kouzaburo, Sarashina, Hiromi, Todoroki, Takeshi, Tanaka, Sachiko, Kitamura, Tsugio, Saito, Akiko, Obata, Hiroshi, Yoshida, Takanobu, Yoshino, Masahiro, Matsui, Osamu, Takashima, Tsutomu, Tokuyama, Katsuyuki, Jinno, Kenji, Kondo, Fukuo, Ebara, Masaaki, Sugihara, Shigetaka, Kojiro, Masamichi, Shoji, Masamitsu, Kobori, Ohichiro, Haruma, Ken, Tokutomi, Tadashi, Saito, T., Kobayashi, M., Shirohzu, Genzan, Kakegawa, Teruo, Yamaki, Goro, Maruyama, Toshihide, Sugihara, Takashi, Mitomi, Toshio, Yamada, Akiyoshi, Itoh, Tadahiko, Yoshida, Tomoharu, Udagawa, Harushi, Tsurumaru, Masahiko, Yasui, Akihiro, Nimura, Yuji, Ri, Sigen, Nabeya, Kin-Ichi, Fujita, Hideharu, Noto, Hirofumi, Sano, Fumio, Uchino, Junichi, Kawaura, Yukimitsu, Mori, Yoshihiro, Kano, Tomoyuki, Ito, Yoshiaki, Hishikawa, Yoshio, Miura, Takashi, Karaki, Yoshiaki, Fujimaki, Masao, Kashiwagi, Toni, Koizumi, Takeo, Hata, Yoshinobu, Itoh, Kazuo, Sato, Shizou, Mimura, Hisashi, Kuniyasu, Yoshio, Takada, Tadanori, Nakajima, Michiko, Itoh, Susumu, Bando, Tsuyoshi, Tanaka, Michio, Aibe, Tsuyoshi, Fujimura, Hiroshi, Hayashi, Yoshiki, Kimoto, Eizo, Ohishi, Hajime, Morita, Tomofumi, Sugano, Shigeo, Abei, Tohru, Ikari, T., Ariyama, J., Ibuki, Yoshikazu, Kuronuma, Yukio, Kodama, Takahiro, Numa, Yoshinori, Saito, K., Kasukawa, R., Kagawa, Hiroyuki, Nishioka, Mikio, Imai, Haruhiko, Kiyosawa, Kendo, Abe, Hirohiko, Tanikawa, Kyuichi, Furusawa, Akihiko, Takase, Kojiro, Kosaka, Yoshitane, Higuchi, Kiyohiro, Matsui, Shinjiro, Watanabe, Satoshi, Ichida, Fumihiro, Kato, Yasuhiro, Shimizu, Masanori, Yuh, Kouichi, Yagisawa, Hitoshi, Komatsu, Masafumi, Maeda, Takashi, Miyazaki, Masako, Ishii, Hideo, Usui, Kou, Oda, M., Komatsu, H., Mizoguchi, Yasuhiro, Kuroki, Tetsuo, Mori, Yoshio, Ogawa, Makoto, Mori, Teruo, Ueda, Shiro, Yoshida, Hiromichi, Wakashin, Yoko, Wakashin, Masafumi, Okuda, Kunio, Watanabe, Yasuyuki, Kawakami, Hiroiku, Nonomura, Akitaka, Ohta, Goroku, Suzuki, Hiroshi, Takino, Tatsuro, Kawaguchi, Hideki, Ichida, Fumihiro, Hinoue, Yoshinobu, Unoura, Masashi, Mizoguchi, Yasuhiro, Kagawa, Hiroyuki, Nishioka, Mikio, Arakawa, Yasuyuki, Amaki, Schuichi, Ikeda, Kenji, Kumada, Hiromitsu, Ikeda, Toshio, Tarao, Kazuo, Nakano, Masami, Saito, Shozo, Takahashi, Akira, Shimamura, Yoshiyuki, Matsuda, Yoshiro, Yasuhara, Minoru, Matsuo, Yutaka, Miyake, Takeo, Matsuo, Y., Watanabe, Akiharu, Nei, Jinichi, Matsuda, Yoshiro, Iwasaki, Ariyoshi, Sugimura, Fumiaki, Yamagata, Susumu, Arakawa, Tetsuo, Kobayashi, Kenzo, Miyamoto, Shintaro, Yukawa, Eiyo, Kitajima, Masaki, Seki, Manabu, Murakami, M., Kobayashi, Y., Mizuno, M., Yoo, J. K., Saita, H., Inoue, R., Inada, M., Miyake, T., Hirai, Nobuyuki, Tanaka, Nobuyoshi, Miyake, Takeo, Ando, Keijiro, Sanuki, Kazutoshi, Inui, Kazuo, Nakazawa, Saburo, Tanaka, Ryoji, Ukida, Minoru, Miyashita, Tadashi, Tobe, Takayoshi, Kosen, Kenzo, Takahashi, Hiroshi, Kadota, Toshio, Tamakuma, Shouetsu, Kitano, Seigo, Sugimachi, Keizo, Nakao, Akimasa, Takagi, Hiroshi, Sawai, Kiyoshi, Takahashi, Toshio, Kusano, Toshiomi, Furukawa, Masato, Yamane, Tetsuro, Takahashi, Toshio, and Iida, Shuhei

Published
1987
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40. Abstracts of selected papers presented at the 73rd general meeting of The Japanese Society of Gastroenterology: Tokyo, Japan, April 7–9, 1987

Author

Nakama, Hidenori, Saito, Hiroshi, Kakizaki, Ryosuke, Takeshita, Toshitaka, Chen, Pei-Chin, Asaka, Masahiro, Saitoh, Masao, Toyohara, Tokiaki, Murakami, Taihei, Fujita, Masahide, Taguchi, Tetsuo, Tada, Masahiro, Yamaguchi, Nozomi, Yoshikawa, N., Miyaji, Makoto, Hoshino, Makoto, Satoh, Tatsuyuki, Kodama, Tadashi, Yamao, Kenji, Naito, Yasuo, Fuji, Tadasu, Aibe, Tsuyoshi, Wada, Yoshiyuki, Kimura, Wataru, Uchiyama, Kanenari, Tatekawa, Isao, Nakayama, Toshimichi, Yoshida, Tadashi, Nagakawa, Takukazu, Miyashita, Tadashi, Uchida, Kotaro, Kobari, Masao, Sato, Toshio, Imaizumi, Toshihide, Hanyu, Fujio, Ohshiba, Saburo, Nishizawa, Mamoru, Takemoto, Tadayoshi, Miyake, Takeo, Watanabe, Hidenobu, Kawai, Keiich, Miwa, Takeshi, Nagao, Fusahiro, Aoki, Teruaki, Chikamori, Fumio, Takase, Yasuhiro, Miyoshi, Hirofumi, Toyonaga, Atsushi, Takeshige, Kotohito, Futagawa, Shunji, Ono, Jiroichi, Imai, Fukashi, and Kumada, Hiromitsu

Published
1988
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42. An important role of endothelial hairy-related transcription factors in mouse vascular development.

Author

Morioka, Takashi, Sakabe, Masahide, Ioka, Tomoko, Iguchi, Tomoko, Mizuta, Ken, Hattammaru, Miwa, Sakai, Chihiro, Itoh, Munehiro, Sato, Genki E., Hashimoto, Aya, Fujita, Masahide, Okumura, Kazuki, Araki, Mutsumi, Xin, Mei, Pedersen, Roger A., Utset, Manuel F., Kimura, Hiroshi, Nakagawa, Osamu, Morioka, Takashi, Sakabe, Masahide, Ioka, Tomoko, Iguchi, Tomoko, Mizuta, Ken, Hattammaru, Miwa, Sakai, Chihiro, Itoh, Munehiro, Sato, Genki E., Hashimoto, Aya, Fujita, Masahide, Okumura, Kazuki, Araki, Mutsumi, Xin, Mei, Pedersen, Roger A., Utset, Manuel F., Kimura, Hiroshi, and Nakagawa, Osamu

Abstract

The Hairy-related transcription factor family of Notch- and ALK1-downstream transcriptional repressors, called Hrt/Hey/Hesr/Chf/Herp/Gridlock, has complementary and indispensable functions for vascular development. While mouse embryos null for either Hrt1/Hey1 or Hrt2/Hey2 did not show early vascular phenotypes, Hrt1/Hey1; Hrt2/Hey2 double null mice (H1ko/H2ko) showed embryonic lethality with severe impairment of vascular morphogenesis. It remained unclear, however, whether Hrt/Hey functions are required in endothelial cells or vascular smooth muscle cells. In this study, we demonstrate that mice with endothelial-specific deletion of Hrt2/Hey2 combined with global Hrt1/Hey1 deletion (H1ko/H2eko) show abnormal vascular morphogenesis and embryonic lethality. Their defects were characterized by the failure of vascular network formation in the yolk sac, abnormalities of embryonic vascular structures and impaired smooth muscle cell recruitment, and were virtually identical to the H1ko/H2ko phenotypes. Among signaling molecules implicated in vascular development, Robo4 expression was significantly increased and activation of Src family kinases was suppressed in endothelial cells of H1ko/H2eko embryos. The present study indicates an important role of Hrt1/Hey1 and Hrt2/Hey2 in endothelial cells during early vascular development, and further suggests involvement of Robo4 and Src family kinases in the mechanisms of embryonic vascular defects caused by the Hrt/Hey deficiency., 博士（医学）・乙第1352号・平成27年3月16日, © 2014 Wiley Periodicals, Inc., 発行元が定める登録猶予期間終了の後、本文を登録予定（2015.11）

Published
2015

46. Cover Image

Author

Mizuta, Ken, primary, Sakabe, Masahide, additional, Hashimoto, Aya, additional, Ioka, Tomoko, additional, Sakai, Chihiro, additional, Okumura, Kazuki, additional, Hattammaru, Miwa, additional, Fujita, Masahide, additional, Araki, Mutsumi, additional, Somekawa, Satoshi, additional, Saito, Yoshihiko, additional, and Nakagawa, Osamu, additional

Published
2014
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47. Impairment of endothelial‐mesenchymal transformation during atrioventricular cushion formation in Tmem100 null embryos

Author

Mizuta, Ken, primary, Sakabe, Masahide, additional, Hashimoto, Aya, additional, Ioka, Tomoko, additional, Sakai, Chihiro, additional, Okumura, Kazuki, additional, Hattammaru, Miwa, additional, Fujita, Masahide, additional, Araki, Mutsumi, additional, Somekawa, Satoshi, additional, Saito, Yoshihiko, additional, and Nakagawa, Osamu, additional

Published
2014
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48. An important role of endothelial hairy‐related transcription factors in mouse vascular development

Author

Morioka, Takashi, primary, Sakabe, Masahide, additional, Ioka, Tomoko, additional, Iguchi, Tomoko, additional, Mizuta, Ken, additional, Hattammaru, Miwa, additional, Sakai, Chihiro, additional, Itoh, Munehiro, additional, Sato, Genki E., additional, Hashimoto, Aya, additional, Fujita, Masahide, additional, Okumura, Kazuki, additional, Araki, Mutsumi, additional, Xin, Mei, additional, Pedersen, Roger A., additional, Utset, Manuel F., additional, Kimura, Hiroshi, additional, and Nakagawa, Osamu, additional

Published
2014
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50. G protein-gated inwardly rectifying potassium (KIR3) channels play a primary role in the antinociceptive effect of oxycodone, but not morphine, at supraspinal sites

Author

Nakamura, Atsushi, primary, Fujita, Masahide, additional, Ono, Hiroko, additional, Hongo, Yoshie, additional, Kanbara, Tomoe, additional, Ogawa, Koichi, additional, Morioka, Yasuhide, additional, Nishiyori, Atsushi, additional, Shibasaki, Masahiro, additional, Mori, Tomohisa, additional, Suzuki, Tsutomu, additional, Sakaguchi, Gaku, additional, Kato, Akira, additional, and Hasegawa, Minoru, additional

Published
2013
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