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33 results on '"Fujise, Yuki"'

13. Left Renal Cortical Thickness Measured by Ultrasound Can Predict Early Progression of Chronic Kidney Disease

Author

Takata, Tomoaki, primary, Koda, Masahiko, additional, Sugihara, Takaaki, additional, Sugihara, Shinobu, additional, Okamoto, Toshiaki, additional, Miyoshi, Kenichi, additional, Hodotsuka, Masanori, additional, Fujise, Yuki, additional, Matono, Tomomitsu, additional, Okano, Junichi, additional, Hosho, Keiko, additional, Iyama, Takuji, additional, Fukui, Takeaki, additional, Fukuda, Satoko, additional, Munemura, Chishio, additional, and Isomoto, Hajime, additional

Published
2015
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15. Rapid and early α-fetoprotein and des-γ-carboxy prothrombin responses to initial arterial infusion chemotherapy predict treatment outcomes of advanced hepatocellular carcinoma

Author

OYAMA, KENJI, primary, KODA, MASAHIKO, additional, SUGIHARA, TAKAAKI, additional, KISHINA, MANABU, additional, MIYOSHI, KENICHI, additional, OKAMOTO, TOSHIAKI, additional, HODOTSUKA, MASANORI, additional, FUJISE, YUKI, additional, MATONO, TOMOMITSU, additional, TOKUNAGA, SHIHO, additional, OKAMOTO, KINYA, additional, HOSHO, KEIKO, additional, OKANO, JUNICHI, additional, and MURAWAKI, YOSHIKAZU, additional

Published
2015
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17. Difference of health-care associated pneumonia between large hospitals and small hospitals in Japan

Author

Watanabe, Masanari, Kato, Kazuhiro, Takeda, Kenichi, Konishi, Tatsuya, Kurai, Jun, Tatsukawa, Toshiyuki, Yamamoto, Hiroyuki, Tamura, Yoshisato, Ishikawa, Soichiro, Kawasaki, Yuji, Morita, Masato, Yoneda, Kazuhiko, Fujise, Hidechika, Fujise, Yuki, Fujise, Kazuomi, Yamaguchi, Kosuke, Hayabuchi, Tatsuya, Shigeshiro, Keji, Katayama, Satoru, Chikumi, Hiroki, Igishi, Tadashi, Yamasaki, Akira, Hasegawa, Yasuyuki, Okazaki, Ryota, Burioka, Naoto, Shimizu, Eiji, Watanabe, Masanari, Kato, Kazuhiro, Takeda, Kenichi, Konishi, Tatsuya, Kurai, Jun, Tatsukawa, Toshiyuki, Yamamoto, Hiroyuki, Tamura, Yoshisato, Ishikawa, Soichiro, Kawasaki, Yuji, Morita, Masato, Yoneda, Kazuhiko, Fujise, Hidechika, Fujise, Yuki, Fujise, Kazuomi, Yamaguchi, Kosuke, Hayabuchi, Tatsuya, Shigeshiro, Keji, Katayama, Satoru, Chikumi, Hiroki, Igishi, Tadashi, Yamasaki, Akira, Hasegawa, Yasuyuki, Okazaki, Ryota, Burioka, Naoto, and Shimizu, Eiji

Abstract

Objective : Health-care associated pneumonia (HCAP) is a new category of pneumonia. We investigated differences of epidemiology, pathogens, and outcomes between HCAP patients in large hospitals and those in small hospitals. Methods : This was a retrospective observational study of patients hospitalized with HCAP from December 2009 to March 2010. HCAP was defined according to ATS/IDSA criteria. A large hospital was defined as 200 beds and a small hospital was 200 beds. Results : Of 117 patients, 61 patients were admitted to large hospitals and 56 patients were admitted to small hospitals. There was a significant difference of HCAP diagnostic criteria between the two groups. The A-DROP severity class was worse in the large hospital group than the small hospital group (P 0.05). Respiratory failure and disturbance of consciousness were more frequent in the large hospital group (P 0.05). The mortality rate was 8.2% in the large hospital group versus 1.8% in the small hospital group. Patients in the very severe A-DROP class had a high mortality rate of 33% in both groups. Conclusion : Patients with severe HCAP were more likely to be admitted to large hospitals. Patients in the very severe A-DROP class should receive intensive antibiotic therapy, but not all patients need broad-spectrum therapy.

Published
2011

22. Assessment of ablative margin after radiofrequency ablation for hepatocellular carcinoma; comparison between magnetic resonance imaging with ferucarbotran and enhanced CT with iodized oil deposition

Author

Koda, Masahiko, primary, Tokunaga, Shiho, additional, Fujise, Yuki, additional, Kato, Jun, additional, Matono, Tomomitsu, additional, Sugihara, Takaaki, additional, Nagahara, Takakazu, additional, Ueki, Masaru, additional, Murawaki, Yoshikazu, additional, Kakite, Suguru, additional, and Yamashita, Eijiro, additional

Published
2012
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23. A severe drug induced hepatitis caused by a dietary supplement "Nin-niku Ran-oh" made from garlic and egg yolk

Author

Okamoto, Kinya, primary, Miyoshi, Ken-ichi, additional, Kishina, Manabu, additional, Fujise, Yuki, additional, Kato, Jyun, additional, Tokunaga, Shiho, additional, Matono, Tomomitsu, additional, Hosyo, Keiko, additional, Oyama, Kenji, additional, Okano, Jyun-ichi, additional, Maeda, Naoto, additional, Koda, Masahiko, additional, and Murawaki, Yoshikazu, additional

Published
2012
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25. Drug-induced hepatic injury caused by an aldose reductase inhibitor, epalrestat

Author

Fujise, Yuki, primary, Koda, Masahiko, additional, Kato, Jun, additional, Tokunaga, Shiho, additional, Matono, Tomomitsu, additional, Sugihara, Takaaki, additional, Nagahara, Takakazu, additional, Ueki, Masaru, additional, Okamoto, Kinya, additional, Oyama, Kenji, additional, Okano, Jun-ichi, additional, Maeda, Naoto, additional, Kuwamoto, Satoshi, additional, and Murawaki, Yoshikazu, additional

Published
2011
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26. Difference of health-care associated pneumonia between large hospitals and small hospitals in Japan

Author

Watanabe, Masanari, primary, Kato, Kazuhiro, additional, Takeda, Kenichi, additional, Konishi, Tatsuya, additional, Kurai, Jun, additional, Tatsukawa, Toshiyuki, additional, Yamamoto, Hiroyuki, additional, Tamura, Yoshisato, additional, Ishikawa, Soichiro, additional, Kawasaki, Yuji, additional, Morita, Masato, additional, Yoneda, Kazuhiko, additional, Fujise, Hidechika, additional, Fujise, Yuki, additional, Fujise, Kazuomi, additional, Yamaguchi, Kosuke, additional, Hayabuchi, Tatsuya, additional, Shigeshiro, Keji, additional, Katayama, Satoru, additional, Chikumi, Hiroki, additional, Igishi, Tadashi, additional, Yamasaki, Akira, additional, Hasegawa, Yasuyuki, additional, Okazaki, Ryota, additional, Burioka, Naoto, additional, and Shimizu, Eiji, additional

Published
2011
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27. Two cases of amebic liver abscess infected by heterosexual intercourse

Author

Tanimoto, Takufumi, primary, Sugihara, Takaaki, additional, Fujise, Yuki, additional, Kato, Jun, additional, Tokunaga, Shiho, additional, Matono, Tomomitsu, additional, Nagahara, Takakazu, additional, Ueki, Masaru, additional, Okamoto, Kinya, additional, Oyama, Kenji, additional, Okano, Junichi, additional, Maeda, Naoto, additional, Koda, Masahiko, additional, Murawaki, Yoshikazu, additional, and Yoneda, Kazuhiko, additional

Published
2010
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28. Left Renal Cortical Thickness Measured by Ultrasound Can Predict Early Progression of Chronic Kidney Disease

Author

Takata, Tomoaki, Koda, Masahiko, Sugihara, Takaaki, Sugihara, Shinobu, Okamoto, Toshiaki, Miyoshi, Kenichi, Hodotsuka, Masanori, Fujise, Yuki, Matono, Tomomitsu, Okano, Junichi, Hosho, Keiko, Iyama, Takuji, Fukui, Takeaki, Fukuda, Satoko, Munemura, Chishio, and Isomoto, Hajime

Abstract

AbstractAims:The kidney becomes atrophic in advanced chronic kidney disease, and renal size and parenchymal volume correlate with renal function. However, alterations in renal parenchymal volume have not been adequately studied in terms of the renal cortex and medulla. We investigated the relationship between the changes in the renal cortex and medulla and renal function. Methods:Renal ultrasound (US) parameters including renal length, parenchymal thickness, cortical thickness and medullary thickness were assessed in 176 subjects, who were categorized into 4 groups based on the estimated glomerular filtration rate (ml/min/1.73 m2): group 1, ≥90; group 2, ≥60 but <90; group 3, ≥30 but <60; and group 4, <30. Renal US parameters in both kidneys were compared among the 4 groups. Results:We found stepwise associations in renal length, cortical thickness and parenchymal thickness with decreased renal function. Medullary thickness showed no changes among groups 1-3. Multiple linear regression analysis including sex, age and renal US parameters showed that only renal length was an independent predictor of renal function. When analyzed in groups 1-3, cortical thickness was the strongest associated parameter. Lower cortical left/right ratio (left cortical thickness/right cortical thickness) showed a stepwise association with a decrease in renal function. Conclusion:Renal length and cortical thickness measured by US were correlated with renal function. In particular, left cortical thickness could help to detect early changes in renal function.© 2015 S. Karger AG, Basel

Published
2016
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29. [Corrigendum] Preventive effect of caffeine and curcumin on hepato-carcinogenesis in diethylnitrosamine-induced rats.

Author

Fujise Y, Okano J, Nagahara T, Abe R, Imamoto R, and Murawaki Y

Abstract

Following the publication of this article, an interested reader drew to our attention an anomaly associated with the presentation of Figs. 3 and 4; essentially, there was the direct duplication of a panel between Fig. 3B, upper left‑hand panel (the G1-10W data) and Fig. 4B, also the upper left-hand panel (the G1-14W data). In the upper-left panels of Fig. 3B and 4B, we wanted to demon-strate microscopic features of the control liver at 10 weeks and 14 weeks, respectively. After having re-examined our original data, we note that we inadvertently duplicated the picture of the control liver at 14 weeks in the upper‑left panel of Fig. 3B. A corrected version of Fig. 3 is presented below, in which the G1-10W data in Fig. 3B are now correctly shown. Since G1-10W and G1-14W are control images of the liver, exhibiting a normal appearance, this error did not affect the findings in the study. We sincerely apologize for this mistake, and thank the reader of our article who drew this matter to our attention. Furthermore, we regret any inconvenience this mistake has caused. [the original article was published in the International Journal of Oncology 40: 1779-1788, 2012; DOI: 10.3892/ijo.2012.1343].

Published
2016
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30. Null anticarcinogenic effect of silymarin on diethylnitrosamine-induced hepatocarcinogenesis in rats.

Author

Imamoto R, Okano JI, Sawada S, Fujise Y, Abe R, and Murawaki Y

Abstract

The aim of this study was to investigate the anticarcinogenic effects of silymarin in diethylnitrosamine (DEN)-induced hepatocarcinogenic rat models. Severe and mild models of hepatocellular carcinoma (HCC) were generated by the intraperitoneal administration of 40 mg/kg DEN once a week for 18 weeks and 100 mg/kg DEN every 2 weeks for 6 weeks in male Wistar rats, respectively. In the severe and mild models of HCC, the rats were treated with 0.1 and 0.5% silymarin for 18 weeks and with 0.1% silymarin for 5 weeks, respectively. Serum transaminase levels were not significantly decreased by the silymarin treatment in either model. Macroscopic and microscopic features indicated that the silymarin-containing formulations did not significantly inhibit the hepatic tumor formation induced by DEN. Furthermore, immunohistochemical and western blot analyses demonstrated that the expression levels of proliferating cell nuclear antigen and glutathione S -transferase P, which are hepatocarcinogenic markers, were not significantly modified by the silymarin treatment. These results indicate that silymarin may not be considered as a candidate agent against hepatocarcinogenesis.

Published
2014
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31. Preventive effect of caffeine and curcumin on hepato-carcinogenesis in diethylnitrosamine-induced rats.

Author

Fujise Y, Okano J, Nagahara T, Abe R, Imamoto R, and Murawaki Y

Subjects
Animals, Anticarcinogenic Agents pharmacology, Caffeine pharmacology, Carcinoma, Hepatocellular chemically induced, Carcinoma, Hepatocellular pathology, Curcumin pharmacology, Diethylnitrosamine, Glutathione S-Transferase pi metabolism, Liver drug effects, Liver metabolism, Liver pathology, Liver Neoplasms chemically induced, Liver Neoplasms pathology, Male, Organ Size drug effects, Proliferating Cell Nuclear Antigen metabolism, Rats, Rats, Wistar, Transaminases blood, Anticarcinogenic Agents therapeutic use, Caffeine therapeutic use, Carcinoma, Hepatocellular prevention & control, Curcumin therapeutic use, Liver Neoplasms prevention & control
Abstract

Chemopreventive effects of caffeine and curcumin were evaluated in the diethylnitrosamine (DEN)-induced hepatocarcinogenic rat model. Animals injected with DEN for 10 weeks (G2-10w) and 14 weeks (G2-14w) were hepato-carcinogenic rats. Animals injected with DEN and treated with curcumin and caffeine for 10 weeks (G3-10w, G4-10w) and 14 weeks (G3-14w, G4-14w) were compared with those in G2. Macroscopic and microscopic features suggested that treatment with caffeine, but not curcumin, for 10 and 14 weeks was effective in inhibiting DEN-induced hepatocarcinogenesis. Immunohistochemical and western blot analysis with proliferating cell nuclear antigen and glutathione S-transferase-P antibodies also showed that expression levels of these hepato-carcinogenic markers were more efficiently reduced by treatment with caffeine than curcumin. Our data demonstrate that caffeine could be a more potent compound than curcumin for prevention of hepatocarcinogenesis in DEN-induced rats.

Published
2012
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32. [Evaluation of the surveillance program for hepatocellular carcinoma].

Author

Abe R, Okano J, Imamoto R, Fujise Y, Koda M, and Murawaki Y

Subjects
Aged, Carcinoma, Hepatocellular mortality, Female, Humans, Liver Neoplasms mortality, Male, Population Surveillance, Practice Guidelines as Topic, Prognosis, Carcinoma, Hepatocellular diagnosis, Liver Neoplasms diagnosis
Abstract

We examined the compliance with, and efficacy of, the clinical guideline for the diagnosis of hepatocellular carcinoma (HCC). We classified 74 patients with HCC into 3 categories;23 surveillance cases, 18 non-surveillance cases, and 33 incidental cases. Patients from affiliated hospitals included more non-surveillance and incidental cases than in university hospital-treated cases. HCC was diagnosed at an earlier stage in the surveillance group than the incidental group, and the surveillance group had a better outcome than the incidental group. There was no significant difference in HCC stage or outcome between surveillance and non-surveillance groups. The guidelines appeared to be useful for early diagnosis of HCC except for the fact that some in the surveillance group were diagnosed at an advanced stage and around 30% of the incidental group had some risk factors of HCC. Those conducting surveillance must improve their skills for early diagnosis of HCC and both doctors and patients must increase compliance with the guidelines.

Published
2012

33. Sequential analysis of diethylnitrosamine-induced hepatocarcinogenesis in rats.

Author

Abe R, Okano JI, Imamoto R, Fujise Y, and Murawaki Y

Abstract

In the present study, we examined the sequential changes of diethylnitrosamine (DEN)-induced hepatocarcinogenesis in Wistar rats. After 14 weeks of DEN treatment, hyperplastic nodules developed as a consequence of the appearance of renewed hepatocytes, degenerated hepatocytes, oval cells and fibrotic changes. Total bilirubin and alanine aminotransferase levels were significantly higher in the DEN group compared to the control group throughout the experimental period. Our data may prove beneficial to future analyses of chemopreventive compounds during various stages of hepatocarcinogenesis in rats.

Published
2012
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