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173 results on '"Fujioka, Mikihiro"'

28. Evaluation of femoral perfusion using dynamic contrast-enhanced MRI after simultaneous initiation of electrical stimulation and steroid treatment in an osteonecrosis model

Author

Yamamoto, Hiroki, primary, Ueshima, Keiichiro, additional, Saito, Masazumi, additional, Ikoma, Kazuya, additional, Ishida, Masashi, additional, Goto, Tsuyoshi, additional, Hayashi, Shigeki, additional, Ikegami, Akira, additional, Fujioka, Mikihiro, additional, Mazda, Osam, additional, and Kubo, Toshikazu, additional

Published
2018
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29. Vitamin E prevents steroid-induced osteonecrosis in rabbits

Author

Kuribayashi, Masaaki, Fujioka, Mikihiro, Takahashi, Kenji A, Arai, Yuji, Ishida, Masashi, Goto, Tsuyoshi, and Kubo, Toshikazu

Subjects
Male, alpha-Tocopherol, Osteonecrosis, Vitamins, General Medicine, Methylprednisolone, Disease Models, Animal, Femur Head Necrosis, Animals, Orthopedics and Sports Medicine, Surgery, Rabbits, Glucocorticoids, Research Article
Abstract

Background and purpose Prevention of osteonecrosis after corticosteroid administration would be important. We examined the potential of vitamin E (α-tocopherol) to reduce the incidence of corticosteroid-induced osteonecrosis in an animal model. Methods Japanese white rabbits were divided into 2 groups; the control group was fed a normal diet and the experimental group was fed α-tocopherol-supplemented diet in which α-tocopherol (600 mg/kg diet) was added to the normal diet. To induce osteonecrosis, high-dose methylprednisolone acetate (MPSL) (20 mg/kg body weight) was injected once into the right gluteus medius muscle of all rabbits. 4 weeks after the injection of MPSL, the presence or absence of osteonecrosis of bilateral femurs was examined histopathologically. The tocopherol/cholesterol ratios were calculated. The plasma levels of thiobarbituric acid-reactive substances (TBARS) were measured. Results Alpha-tocopherol-supplemented diet reduced the incidence of osteonecrosis, which developed in 14 of 20 rabbits in the control group and 5 of 21 rabbits in the experimental group (p = 0.004). The tocopherol/cholesterol ratio was higher in the experimental group than in the control group after the α-tocopherol administration. The plasma TBARS level was lower in the experimental group than in the control group at 4 weeks after the MPSL administration. Interpretation Our findings may offer a new approach for the prevention of corticosteroid-induced osteonecrosis.

Published
2010

32. Evaluation of femoral perfusion in a rabbit model of steroid-induced osteonecrosis by dynamic contrast-enhanced mri with a high magnetic field MRI system

Author

Hayashi, Shigeki, primary, Fujioka, Mikihiro, additional, Ikoma, Kazuya, additional, Saito, Masazumi, additional, Ueshima, Keiichiro, additional, Ishida, Masashi, additional, Kuribayashi, Masaaki, additional, Ikegami, Akira, additional, Mazda, Osam, additional, and Kubo, Toshikazu, additional

Published
2014
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34. Electromagnetic Fields

Author

Ishida, Masashi, primary, Fujioka, Mikihiro, additional, Takahashi, Kenji A., additional, Arai, Yuji, additional, and Kubo, Toshikazu, additional

Published
2008
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35. Degree of corticosteroid treatment within the first 2 months of renal transplantation has a strong influence on the incidence of osteonecrosis of the femoral head

Author

Shibatani, Masahiko, primary, Fujioka, Mikihiro, additional, Arai, Yuji, additional, Takahashi, Kenji, additional, Ueshima, Keiichiro, additional, Okamoto, Masahiko, additional, Yoshimura, Norio, additional, Hirota, Yoshio, additional, Fukushima, Wakaba, additional, and Kubo, Toshikazu, additional

Published
2008
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36. A functional polymorphism in the 5′ UTR of GDF5 is associated with susceptibility to osteoarthritis

Author

Miyamoto, Yoshinari, primary, Mabuchi, Akihiko, additional, Shi, Dongquan, additional, Kubo, Toshikazu, additional, Takatori, Yoshio, additional, Saito, Susumu, additional, Fujioka, Mikihiro, additional, Sudo, Akihiro, additional, Uchida, Atsumasa, additional, Yamamoto, Seizo, additional, Ozaki, Koichi, additional, Takigawa, Masaharu, additional, Tanaka, Toshihiro, additional, Nakamura, Yusuke, additional, Jiang, Qing, additional, and Ikegawa, Shiro, additional

Published
2007
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38. Incidence of physeal injuries in Japanese children

Author

Kawamoto, Kouei, primary, Kim, Wook-cheol, additional, Tsuchida, Yuichi, additional, Tsuji, Yoshiro, additional, Fujioka, Mikihiro, additional, Horii, Motoyuki, additional, Mikami, Yasuo, additional, Tokunaga, Daisaku, additional, and Kubo, Toshikazu, additional

Published
2006
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41. Usefulness of epiphyseal quotient measurement on magnetic resonance images for outcome prediction in patients with early-stage Legg–Calvé–Perthes disease

Author

Tsuchida, Yuichi, primary, Kim, Wook-Cheol, additional, Takahashi, Kenji A., additional, Horii, Motoyuki, additional, Mikami, Yasuo, additional, Fujioka, Mikihiro, additional, Kusakabe, Torao, additional, Chang, Kyung, additional, Hosokawa, Motoo, additional, and Kubo, Toshikazu, additional

Published
2005
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42. Relationship between postrenal transplant osteonecrosis of the femoral head and gene polymorphisms related to the coagulation and fibrinolytic systems in Japanese subjects

Author

Asano, Takeshi, primary, Takahashi, Kenji A., additional, Fujioka, Mikihiro, additional, Inoue, Shigehiro, additional, Ueshima, Keiichiro, additional, Hirata, Tetsurou, additional, Okamoto, Masahiko, additional, Satomi, Yoshiko, additional, Nishino, Hoyoku, additional, Tanaka, Takashi, additional, Hirota, Yoshio, additional, and Kubo, Toshikazu, additional

Published
2004
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48. Preoperative Fluoroscopic Imaging Reduces Variability of Acetabular Component Positioning.

Author

Nishikubo, Yoshiki, Fujioka, Mikihiro, Ueshima, Keiichiro, Saito, Masazumi, and Kubo, Toshikazu

Abstract

Abstract: We evaluated the preoperative errors in the pelvic tilt of 249 hips before total hip arthroplasty using fluoroscopic imaging while the patients were in the lateral decubitus position. The mean absolute value errors of the pelvic tilt were 2.94° (SD, 2.92°), 2.49° (SD, 2.68°), and 5.92° (SD, 5.20°) in the coronal, transverse, and sagittal planes, respectively. Such preoperative errors in the pelvic tilt contribute to malpositioning of the acetabular component, as is frequently observed on postoperative radiographs. We reduced the incidence of malpositioning by correcting the errors in the pelvic tilt through repositioning of the operating table using fluoroscopic imaging before surgery. The new technique using fluoroscopic imaging described in this article can be performed within a short time without a navigation system. [Copyright &y& Elsevier]

Published
2011
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49. Low Molecular Weight Phenotype of Apolipoprotein(a) Is a Risk Factor of Corticosteroid-Induced Osteonecrosis of the Femoral Head After Renal Transplant

Author

Hirata, Tetsurou, Fujioka, Mikihiro, Takahashi, Kenji, Asano, Takeshi, Ishida, Masashi, Akioka, Kiyokazu, Okamoto, Masahiko, Yoshimura, Norio, Satomi, Yoshiko, Nishino, Hoyoku, Hirota, Yoshio, Nakajima, Shigeo, Kato, Shigeaki, and Kubo, Toshikazu

Abstract

OBJECTIVE: Osteonecrosis of the femoral head (ONF) is a necrosis due to disruption of the blood flow. The disease often occurs in association with corticosteroid treatment. The pathology of corticosteroid-induced ONF is unclear, although abnormalities in the coagulation and fibrinolytic systems or in the lipid metabolism have been reported to be involved. We examined the relationships between development of ONF and genetic variations and plasma level of lipoprotein(a) (Lp(a)), which is closely involved in the coagulation and fibrinolytic systems and lipid metabolism. METHODS: The study population consisted of 112 renal transplant patients undergoing corticosteroid treatment. Their apolipoprotein (a) [apo(a)] isoform was determined by Western blotting, and patients were classified into low molecular weight (LMW) or high molecular weight (HMW) groups. The plasma Lp(a) level was measured. Patients were also examined for 3 single-nucleotide polymorphisms (SNP), -773 (G/A), +93 (C/T), and +121 (G/A). Relationships between these 3 genetic factors of Lp(a) and ONF development were examined using statistical methods including multivariate analysis. RESULTS: A strong relationship was observed between the apo(a) molecular weight phenotype and ONF development, with an increased risk of ONF development for the LMW group (adjusted odds ratio 5.75, 95% CI 1.76-18.74, p = 0.0038). No significant relationships were observed between ONF and plasma Lp(a) level and SNP. CONCLUSION: Apo(a) molecular weight phenotype would be a useful predictor of ONF that develops after corticosteroid treatment.

Published
2007

50. ABCB1C3435T and G2677T/A polymorphism decreased the risk for steroid-induced osteonecrosis of the femoral head after kidney transplantation

Author

Asano, Takeshi, Takahashi, Kenji A, Fujioka, Mikihiro, Inoue, Shigehiro, Okamoto, Masahiko, Sugioka, Nobuyuki, Nishino, Hoyoku, Tanaka, Takashi, Hirota, Yoshio, and Kubo, Toshikazu

Abstract

Advances in transplantation technology have brought about great benefits to patients suffering from organ failure, but the problem still remains of complications induced by steroids used for post-transplant immunosuppression. Among the side-effects caused by steroids, non-traumatic osteonecrosis of the femoral head (ONF) constitutes a serious problem. The same protocol for steroid administration induces ONF in some patients, but not in others, indicating the presence of individual difference in steroid sensitivity. We hypothesized that this difference might be mediated by the drug-transport protein, P-glycoprotein (P-gp), and investigated the relationship between single nucleotide polymorphisms in the multidrug resistance gene 1 (ABCB1, MDR1) encoding P-gp and ONF. Subjects comprised 136 patients receiving kidney transplantation. Thirty patients developed post-transplant ONF. Genomic DNA was extracted from peripheral blood, and genotypes of ABCB1C3435T (exon 26) and G2677T/A (exon 21) were determined by direct sequencing. Multivariate analyses based on clinical information were performed to determine the relationship between ABCB1genotypes and ONF. The dose/concentration (D/C) ratios of tacrolimus were also determined to estimate the activity of P-gp in patients with different genotypes of ABCB1C3435T (CC, CT, TT), and in those who did and did not develop ONF. The ABCB13435TT genotype showed a significantly lower incidence of ONF (adjusted odds ratio = 0.10, P= 0.034). The D/C ratio in the 3435TT genotype was significantly higher than that in the 3435CC genotype. The D/C ratio in patients developing ONF was significantly higher than in those patients who did not develop ONF. The results suggest increased activity of P-gp in patients with the 3435TT genotype and in those who did not develop ONF. The ABCB12677 homozygous variant type also showed a lower incidence of ONF (adjusted odds ratio = 0.26, P= 0.056). The 3435T and 3435C alleles were in linkage disequilibrium with the 2677T and the 2677G alleles, respectively, in the study population. An assessment of C3435T and G2677T/A polymorphisms preceding steroid treatment could be useful for predicting the resistance to ONF development.

Published
2003

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